Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
CHEMBL5093342 | 218054 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | None | None | None | CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095971 | 218054 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | None | None | None | CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
11329254 | 85250 | None | 0 | Guinea pig | Functional | pEC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 450 | 9 | 1 | 5 | 4.5 | O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21 | 10.1021/jm070487n | |||
CHEMBL225571 | 85250 | None | 0 | Guinea pig | Functional | pEC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 450 | 9 | 1 | 5 | 4.5 | O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21 | 10.1021/jm070487n | |||
CHEMBL5093342 | 218054 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | None | None | None | CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095971 | 218054 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | None | None | None | CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
134138168 | 147779 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3931889 | 147779 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
135367816 | 164930 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218801 | 164930 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367816 | 164930 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218801 | 164930 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
134138168 | 147779 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3931889 | 147779 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
23643870 | 92917 | None | 0 | Guinea pig | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 448 | 9 | 1 | 4 | 4.6 | CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL243955 | 92917 | None | 0 | Guinea pig | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 448 | 9 | 1 | 4 | 4.6 | CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL5081379 | 217234 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | None | None | None | CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5081379 | 217234 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | None | None | None | CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
135367820 | 164916 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218672 | 164916 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367820 | 164916 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218672 | 164916 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL5094493 | 217989 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | None | None | None | CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5094493 | 217989 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | None | None | None | CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
92042876 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8014553 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8014553 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8014553 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8014553 | |||
92042876 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
3108374 | 92011 | None | 17 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 5 | ChEMBL | 295 | 2 | 0 | 3 | 3.5 | COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2 | 10.1016/j.ejmech.2023.115414 | |||
CHEMBL2414990 | 92011 | None | 17 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 5 | ChEMBL | 295 | 2 | 0 | 3 | 3.5 | COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2 | 10.1016/j.ejmech.2023.115414 | |||
67268994 | 164063 | None | 2 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4207884 | 164063 | None | 2 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
67268994 | 164063 | None | 2 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4207884 | 164063 | None | 2 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367405 | 164291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4210782 | 164291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367405 | 164291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4210782 | 164291 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm500880c | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm500880c | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm500880c | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm500880c | |||
11385992 | 84702 | None | 0 | Guinea pig | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 439 | 8 | 1 | 3 | 5.2 | O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21 | 10.1021/jm070487n | |||
CHEMBL222477 | 84702 | None | 0 | Guinea pig | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 439 | 8 | 1 | 3 | 5.2 | O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21 | 10.1021/jm070487n | |||
23643664 | 2350 | None | 5 | Guinea pig | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 481 | 9 | 1 | 3 | 6.2 | O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm070487n | |||
8434 | 2350 | None | 5 | Guinea pig | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 481 | 9 | 1 | 3 | 6.2 | O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm070487n | |||
CHEMBL243954 | 2350 | None | 5 | Guinea pig | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 481 | 9 | 1 | 3 | 6.2 | O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm070487n | |||
CHEMBL5094234 | 218063 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5096019 | 218063 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5094234 | 218063 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5096019 | 218063 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
11785183 | 84747 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 419 | 8 | 1 | 3 | 4.9 | Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL222755 | 84747 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 419 | 8 | 1 | 3 | 4.9 | Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
124247485 | 164164 | None | 6 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4209274 | 164164 | None | 6 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL5084249 | 217394 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | None | None | None | CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
124247485 | 164164 | None | 6 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4209274 | 164164 | None | 6 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL5084249 | 217394 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | None | None | None | CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
24825775 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3929 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL4205349 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
24825775 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3929 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL4205349 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
102364516 | 113607 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1021/jm500880c | |||
CHEMBL3321794 | 113607 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1021/jm500880c | |||
11282296 | 143402 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 447 | 9 | 1 | 4 | 4.8 | CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL389718 | 143402 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 447 | 9 | 1 | 4 | 4.8 | CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
11224758 | 2353 | None | 4 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -10 | 4 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
8435 | 2353 | None | 4 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -10 | 4 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
CHEMBL225284 | 2353 | None | 4 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -10 | 4 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2021.113243 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2021.113243 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2021.113243 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2021.113243 | |||
25107520 | 187699 | None | 0 | Guinea pig | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 442 | 10 | 1 | 4 | 4.7 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 | 10.1021/jm800615e | |||
CHEMBL494709 | 187699 | None | 0 | Guinea pig | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 442 | 10 | 1 | 4 | 4.7 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 | 10.1021/jm800615e | |||
42625440 | 170916 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 320 | 5 | 0 | 2 | 3.4 | O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 | 10.1021/jm8014553 | |||
CHEMBL445334 | 170916 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 320 | 5 | 0 | 2 | 3.4 | O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1 | 10.1021/jm8014553 | |||
92042877 | 149263 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 241 | 4 | 1 | 2 | 3.4 | CNCc1ccc(C)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3943658 | 149263 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 241 | 4 | 1 | 2 | 3.4 | CNCc1ccc(C)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
92042877 | 149263 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 241 | 4 | 1 | 2 | 3.4 | CNCc1ccc(C)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3943658 | 149263 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 241 | 4 | 1 | 2 | 3.4 | CNCc1ccc(C)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
135367857 | 164699 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4215875 | 164699 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367857 | 164699 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4215875 | 164699 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
92042876 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
92042876 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
134138168 | 147779 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3931889 | 147779 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.8b00642 | |||
134138168 | 147779 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL3931889 | 147779 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
25107648 | 187329 | None | 0 | Guinea pig | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 467 | 8 | 0 | 3 | 5.6 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 | 10.1021/jm800615e | |||
CHEMBL492480 | 187329 | None | 0 | Guinea pig | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 467 | 8 | 0 | 3 | 5.6 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1 | 10.1021/jm800615e | |||
1809 | 134 | None | 25 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -204 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2020.112709 | |||
4 | 134 | None | 25 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -204 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2020.112709 | |||
CHEMBL18840 | 134 | None | 25 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -204 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2020.112709 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2016.07.029 | |||
92042876 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
92042876 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3961059 | 151425 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL5074190 | 216802 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(CCN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5074190 | 216802 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(CCN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5083607 | 217362 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
135453290 | 133675 | None | 29 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -2818 | 7 | ChEMBL | 191 | 2 | 2 | 4 | 1.1 | C[C@H](N)Cn1ncc2ccc(O)cc21 | 10.1021/jm050663x | |||
CHEMBL371300 | 133675 | None | 29 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -2818 | 7 | ChEMBL | 191 | 2 | 2 | 4 | 1.1 | C[C@H](N)Cn1ncc2ccc(O)cc21 | 10.1021/jm050663x | |||
CHEMBL5083607 | 217362 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
118709756 | 113611 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 6 | 0 | 2 | 4.4 | O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 | 10.1021/jm500880c | |||
CHEMBL3321798 | 113611 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 6 | 0 | 2 | 4.4 | O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 | 10.1021/jm500880c | |||
25107716 | 2351 | None | 38 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm800615e | |||
8436 | 2351 | None | 38 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm800615e | |||
CHEMBL522691 | 2351 | None | 38 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm800615e | |||
1809 | 134 | None | 25 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -204 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
4 | 134 | None | 25 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -204 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
CHEMBL18840 | 134 | None | 25 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -204 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
1809 | 134 | None | 25 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | -2238 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm800615e | |||
4 | 134 | None | 25 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | -2238 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm800615e | |||
CHEMBL18840 | 134 | None | 25 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | -2238 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm800615e | |||
1809 | 134 | None | 25 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | -2238 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm070487n | |||
4 | 134 | None | 25 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | -2238 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm070487n | |||
CHEMBL18840 | 134 | None | 25 | Guinea pig | Functional | pEC50 | = | 6.2 | 6.2 | -2238 | 8 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm070487n | |||
11432177 | 85156 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 435 | 9 | 1 | 4 | 4.6 | COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL224820 | 85156 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 435 | 9 | 1 | 4 | 4.6 | COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL5083607 | 217362 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5083607 | 217362 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2018.04.059 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2018.04.059 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2018.04.059 | |||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2020.115578 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2020.115578 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL5091373 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095981 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5091373 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095981 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5091373 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095981 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5091373 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095981 | 218057 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5077293 | 216979 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5077293 | 216979 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5074880 | 216827 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | None | None | None | CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5074880 | 216827 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | None | None | None | CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
11431530 | 84659 | None | 0 | Guinea pig | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 405 | 8 | 1 | 3 | 4.6 | O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21 | 10.1021/jm070487n | |||
CHEMBL222188 | 84659 | None | 0 | Guinea pig | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 405 | 8 | 1 | 3 | 4.6 | O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21 | 10.1021/jm070487n | |||
24825775 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3929 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL4205349 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
24825775 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3929 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL4205349 | 1523 | None | 16 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL5074190 | 216802 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(CCN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5074190 | 216802 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(CCN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
5 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
5202 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL39 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
DB08839 | 139 | None | 45 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -9 | 26 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.1c00110 | |||
23643663 | 92897 | None | 0 | Guinea pig | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 447 | 9 | 1 | 3 | 5.7 | CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL243744 | 92897 | None | 0 | Guinea pig | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 447 | 9 | 1 | 3 | 5.7 | CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL5077293 | 216979 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5077293 | 216979 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
4106 | 2502 | None | 21 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2019.126703 | |||
5358812 | 2502 | None | 21 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2019.126703 | |||
89 | 2502 | None | 21 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2019.126703 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2019.126703 | |||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2018.04.059 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2018.04.059 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2018.04.059 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2018.04.059 | |||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
4106 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.8 | 8.8 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
5358812 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.8 | 8.8 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
89 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.8 | 8.8 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
CHEMBL93240 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.8 | 8.8 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
164609529 | 184570 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | -36 | 2 | ChEMBL | 383 | 5 | 0 | 4 | 4.1 | CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | |||
CHEMBL4846823 | 184570 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | -36 | 2 | ChEMBL | 383 | 5 | 0 | 4 | 4.1 | CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | |||
11391654 | 180631 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 273 | 2 | 1 | 3 | 3.0 | CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 | 10.1016/j.bmcl.2020.127669 | |||
CHEMBL4753511 | 180631 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 273 | 2 | 1 | 3 | 3.0 | CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2 | 10.1016/j.bmcl.2020.127669 | |||
127028798 | 138271 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 454 | 6 | 2 | 5 | 2.4 | Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3769612 | 138271 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 454 | 6 | 2 | 5 | 2.4 | Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 | 10.1016/j.ejmech.2016.02.024 | |||
142601335 | 186527 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876193 | 186527 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
145946966 | 167697 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -144 | 3 | ChEMBL | 354 | 7 | 0 | 4 | 3.9 | COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4209888 | 167697 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -144 | 3 | ChEMBL | 354 | 7 | 0 | 4 | 3.9 | COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4300899 | 167697 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -144 | 3 | ChEMBL | 354 | 7 | 0 | 4 | 3.9 | COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
142601335 | 186527 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876193 | 186527 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
4106 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112709 | |||
5358812 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112709 | |||
89 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112709 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112709 | |||
117209912 | 185443 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4859827 | 185443 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
117209912 | 185443 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4859827 | 185443 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
135339817 | 181590 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 437 | 6 | 0 | 5 | 4.2 | CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O | 10.1016/j.ejmech.2020.112709 | |||
CHEMBL4764679 | 181590 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 437 | 6 | 0 | 5 | 4.2 | CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O | 10.1016/j.ejmech.2020.112709 | |||
206 | 2493 | None | 10 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -97 | 3 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm8014553 | |||
68848 | 2493 | None | 10 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -97 | 3 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm8014553 | |||
CHEMBL12314 | 2493 | None | 10 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -97 | 3 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm8014553 | |||
156013673 | 177366 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 293 | 1 | 2 | 2 | 2.9 | CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL4636148 | 177366 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 293 | 1 | 2 | 2 | 2.9 | CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3 | 10.1016/j.bmc.2020.115578 | |||
127028797 | 138420 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 494 | 6 | 2 | 5 | 3.1 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3771309 | 138420 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 494 | 6 | 2 | 5 | 3.1 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
11536844 | 115186 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343672 | 115186 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
213046 | 2385 | None | 44 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 17 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2021.113243 | |||
213046.0 | 2385 | None | 44 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 17 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2021.113243 | |||
4168 | 2385 | None | 44 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 17 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2021.113243 | |||
7461 | 2385 | None | 44 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 17 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2021.113243 | |||
CHEMBL1237021 | 2385 | None | 44 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 17 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2021.113243 | |||
DB08815 | 2385 | None | 44 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 17 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2021.113243 | |||
142601318 | 185651 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4863036 | 185651 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601318 | 185651 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4863036 | 185651 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
11500509 | 120645 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 3 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343670 | 120645 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 3 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545812 | 120645 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 3 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
117209962 | 184975 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4852622 | 184975 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
117209962 | 184975 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4852622 | 184975 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.8 | Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601343 | 185709 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4863868 | 185709 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601343 | 185709 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4863868 | 185709 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
127029652 | 138415 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 516 | 8 | 2 | 5 | 3.4 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3771222 | 138415 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 516 | 8 | 2 | 5 | 3.4 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
145947937 | 167825 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -32 | 4 | ChEMBL | 398 | 9 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4207653 | 167825 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -32 | 4 | ChEMBL | 398 | 9 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4302655 | 167825 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -32 | 4 | ChEMBL | 398 | 9 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
134141985 | 147264 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 432 | 6 | 0 | 6 | 4.4 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3927929 | 147264 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 432 | 6 | 0 | 6 | 4.4 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 | 10.1016/j.ejmech.2016.07.029 | |||
134141985 | 147264 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 432 | 6 | 0 | 6 | 4.4 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3927929 | 147264 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 432 | 6 | 0 | 6 | 4.4 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2 | 10.1016/j.ejmech.2016.07.029 | |||
44348383 | 16310 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 205 | 3 | 1 | 2 | 2.7 | CSc1ccc2c(c1)C(CCN)=CC2 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL122536 | 16310 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 205 | 3 | 1 | 2 | 2.7 | CSc1ccc2c(c1)C(CCN)=CC2 | 10.1016/j.ejmech.2012.11.042 | |||
4106 | 2502 | None | 21 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2016.02.024 | |||
5358812 | 2502 | None | 21 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2016.02.024 | |||
89 | 2502 | None | 21 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -7 | 7 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2016.02.024 | |||
102364516 | 113607 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1021/jm500880c | |||
CHEMBL3321794 | 113607 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1021/jm500880c | |||
134157289 | 154170 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 422 | 6 | 0 | 4 | 5.3 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3984812 | 154170 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 422 | 6 | 0 | 4 | 5.3 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl | 10.1016/j.ejmech.2016.07.029 | |||
118709756 | 113611 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 352 | 6 | 0 | 2 | 4.4 | O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 | 10.1021/jm500880c | |||
CHEMBL3321798 | 113611 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 352 | 6 | 0 | 2 | 4.4 | O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1 | 10.1021/jm500880c | |||
134157289 | 154170 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 422 | 6 | 0 | 4 | 5.3 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3984812 | 154170 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 422 | 6 | 0 | 4 | 5.3 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl | 10.1016/j.ejmech.2016.07.029 | |||
117209857 | 185244 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4856702 | 185244 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
142601328 | 185109 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4854605 | 185109 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
145946714 | 167657 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -30 | 4 | ChEMBL | 398 | 9 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4213352 | 167657 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -30 | 4 | ChEMBL | 398 | 9 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4300399 | 167657 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -30 | 4 | ChEMBL | 398 | 9 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1 | 10.1016/j.bmcl.2018.04.059 | |||
142601328 | 185109 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4854605 | 185109 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
117209857 | 185244 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4856702 | 185244 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
127029650 | 138353 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 494 | 6 | 2 | 5 | 3.1 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3770581 | 138353 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 494 | 6 | 2 | 5 | 3.1 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
142601333 | 185869 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4866412 | 185869 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
142601328 | 185109 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4854605 | 185109 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
135367820 | 164916 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218672 | 164916 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
142601333 | 185869 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4866412 | 185869 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
142601328 | 185109 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4854605 | 185109 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
135367820 | 164916 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218672 | 164916 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 232 | 1 | 1 | 3 | 2.2 | Fc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367405 | 164291 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4210782 | 164291 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367405 | 164291 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4210782 | 164291 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
156010865 | 177236 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 307 | 0 | 1 | 4 | 3.6 | CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL4633786 | 177236 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 307 | 0 | 1 | 4 | 3.6 | CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3 | 10.1016/j.bmc.2020.115578 | |||
71574210 | 86317 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 2 | 2 | ChEMBL | 478 | 7 | 1 | 5 | 4.0 | O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL2312934 | 86317 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 2 | 2 | ChEMBL | 478 | 7 | 1 | 5 | 4.0 | O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
206 | 2493 | None | 10 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -97 | 3 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm500880c | |||
68848 | 2493 | None | 10 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -97 | 3 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm500880c | |||
CHEMBL12314 | 2493 | None | 10 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -97 | 3 | ChEMBL | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | 10.1021/jm500880c | |||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
3233 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
3247 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
6604889 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
DB13988 | 3512 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 8511 | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
2470 | 3653 | None | 40 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -5128 | 23 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2020.115578 | |||
3300 | 3653 | None | 40 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -5128 | 23 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2020.115578 | |||
5265 | 3653 | None | 40 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -5128 | 23 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2020.115578 | |||
99 | 3653 | None | 40 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -5128 | 23 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL267930 | 3653 | None | 40 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -5128 | 23 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2020.115578 | |||
127028473 | 138360 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 451 | 6 | 2 | 6 | 1.6 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3770639 | 138360 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 451 | 6 | 2 | 6 | 1.6 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
86288948 | 112689 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 456 | 7 | 2 | 6 | 1.8 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3233679 | 112689 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 456 | 7 | 2 | 6 | 1.8 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3302600 | 112689 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 456 | 7 | 2 | 6 | 1.8 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
71574302 | 86298 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -4 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL2312637 | 86298 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -4 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
142601323 | 185947 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccccc1-c1n[nH]cc1N1CCCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4867560 | 185947 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccccc1-c1n[nH]cc1N1CCCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
135367816 | 164930 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218801 | 164930 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
117209971 | 186591 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4877051 | 186591 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
135367816 | 164930 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4218801 | 164930 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 248 | 1 | 1 | 3 | 2.7 | Clc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
142601323 | 185947 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccccc1-c1n[nH]cc1N1CCCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4867560 | 185947 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1ccccc1-c1n[nH]cc1N1CCCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
117209971 | 186591 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4877051 | 186591 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
117209918 | 186516 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876036 | 186516 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
117209918 | 186516 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876036 | 186516 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
11536843 | 115187 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343673 | 115187 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
22001618 | 81844 | None | 10 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 268 | 3 | 1 | 3 | 2.8 | COc1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1021/jm3003679 | |||
CHEMBL2164336 | 81844 | None | 10 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 268 | 3 | 1 | 3 | 2.8 | COc1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1021/jm3003679 | |||
59511191 | 185629 | None | 1 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 228 | 2 | 2 | 3 | 1.5 | c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4862745 | 185629 | None | 1 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 228 | 2 | 2 | 3 | 1.5 | c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
59511191 | 185629 | None | 1 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 228 | 2 | 2 | 3 | 1.5 | c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4862745 | 185629 | None | 1 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 228 | 2 | 2 | 3 | 1.5 | c1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
2737389 | 187692 | None | 22 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 238 | 2 | 1 | 2 | 2.8 | c1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1021/jm3003679 | |||
CHEMBL494675 | 187692 | None | 22 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 238 | 2 | 1 | 2 | 2.8 | c1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1021/jm3003679 | |||
90656694 | 111058 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 339 | 7 | 1 | 4 | 3.4 | CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262428 | 111058 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 339 | 7 | 1 | 4 | 3.4 | CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 | 10.1016/j.ejmech.2014.04.034 | |||
117209911 | 186435 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4874854 | 186435 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
117209911 | 186435 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4874854 | 186435 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccccc1-c1n[nH]cc1N1CCNCC1 | 10.1021/acs.jmedchem.1c01093 | |||
134154531 | 152817 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 418 | 7 | 0 | 5 | 4.7 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3973160 | 152817 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 418 | 7 | 0 | 5 | 4.7 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC | 10.1016/j.ejmech.2016.07.029 | |||
71574306 | 86300 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL2312639 | 86300 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1 | 10.1016/j.ejmech.2012.11.042 | |||
134154531 | 152817 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 418 | 7 | 0 | 5 | 4.7 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3973160 | 152817 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 418 | 7 | 0 | 5 | 4.7 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC | 10.1016/j.ejmech.2016.07.029 | |||
145947560 | 167809 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -19 | 4 | ChEMBL | 344 | 6 | 0 | 3 | 4.2 | Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4212812 | 167809 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -19 | 4 | ChEMBL | 344 | 6 | 0 | 3 | 4.2 | Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4302457 | 167809 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -19 | 4 | ChEMBL | 344 | 6 | 0 | 3 | 4.2 | Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl | 10.1016/j.bmcl.2018.04.059 | |||
11694810 | 120603 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 281 | 1 | 3 | 2 | 1.3 | CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.05.027 | |||
CHEMBL3310123 | 120603 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 281 | 1 | 3 | 2 | 1.3 | CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.05.027 | |||
CHEMBL3545474 | 120603 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 281 | 1 | 3 | 2 | 1.3 | CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.05.027 | |||
127028153 | 138250 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 456 | 7 | 2 | 6 | 1.8 | COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3769441 | 138250 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 456 | 7 | 2 | 6 | 1.8 | COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1 | 10.1016/j.ejmech.2016.02.024 | |||
142601325 | 185975 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.9 | c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4868035 | 185975 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.9 | c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601325 | 185975 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.9 | c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4868035 | 185975 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 242 | 2 | 2 | 3 | 1.9 | c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
117209964 | 186240 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4871980 | 186240 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
134137104 | 142779 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 402 | 6 | 0 | 4 | 5.0 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3892079 | 142779 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 402 | 6 | 0 | 4 | 5.0 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C | 10.1016/j.ejmech.2016.07.029 | |||
134137104 | 142779 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 402 | 6 | 0 | 4 | 5.0 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3892079 | 142779 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 402 | 6 | 0 | 4 | 5.0 | COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C | 10.1016/j.ejmech.2016.07.029 | |||
117209964 | 186240 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4871980 | 186240 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 246 | 2 | 2 | 3 | 1.6 | Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
155510732 | 169623 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 1 | 2 | ChEMBL | 430 | 6 | 1 | 1 | 6.9 | Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 | 10.1016/j.bmcl.2019.126703 | |||
CHEMBL4434876 | 169623 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 1 | 2 | ChEMBL | 430 | 6 | 1 | 1 | 6.9 | Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1 | 10.1016/j.bmcl.2019.126703 | |||
142601329 | 186623 | None | 6 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4877603 | 186623 | None | 6 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
142601329 | 186623 | None | 6 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4877603 | 186623 | None | 6 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 276 | 2 | 2 | 3 | 2.5 | Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
124247485 | 164164 | None | 6 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4209274 | 164164 | None | 6 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
124247485 | 164164 | None | 6 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4209274 | 164164 | None | 6 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
142601337 | 186076 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4869695 | 186076 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601337 | 186076 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4869695 | 186076 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 260 | 2 | 2 | 3 | 2.0 | Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601335 | 186527 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876193 | 186527 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
142601335 | 186527 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876193 | 186527 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
67268994 | 164063 | None | 2 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4207884 | 164063 | None | 2 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
67268994 | 164063 | None | 2 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4207884 | 164063 | None | 2 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
71574212 | 86318 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -4 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL2312935 | 86318 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -4 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
127028472 | 138258 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 470 | 8 | 2 | 6 | 2.2 | CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3769534 | 138258 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 470 | 8 | 2 | 6 | 2.2 | CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
71574204 | 86301 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | 18 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL2312640 | 86301 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | 18 | 2 | ChEMBL | 492 | 8 | 1 | 5 | 4.4 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12 | 10.1016/j.ejmech.2012.11.042 | |||
135367857 | 164699 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4215875 | 164699 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
135367857 | 164699 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4215875 | 164699 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
117209864 | 186140 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4870675 | 186140 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
117209864 | 186140 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4870675 | 186140 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 258 | 3 | 2 | 4 | 1.5 | COc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
117209965 | 185353 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4858338 | 185353 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601341 | 185478 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4860503 | 185478 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
117209965 | 185353 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4858338 | 185353 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1 | 10.1021/acs.jmedchem.1c01093 | |||
142601341 | 185478 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4860503 | 185478 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 272 | 3 | 2 | 4 | 1.9 | COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
117209858 | 184660 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4848305 | 184660 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
117209858 | 184660 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4848305 | 184660 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 262 | 2 | 2 | 3 | 2.1 | Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.0 | 8.0 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.0 | 8.0 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.0 | 8.0 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.0 | 8.0 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.0 | 8.0 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.9 | 7.9 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.8 | 7.8 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
24768520 | 93060 | None | 0 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 434 | 9 | 2 | 4 | 4.6 | CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL244161 | 93060 | None | 0 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 434 | 9 | 2 | 4 | 4.6 | CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.7 | 7.7 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm800615e | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 7.5 | 7.5 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.2 | 8.2 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.2 | 8.2 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.2 | 8.2 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.2 | 8.2 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.2 | 8.2 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3233 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
3247 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
6604889 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
CHEMBL282199 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
DB13988 | 3512 | None | 28 | Guinea pig | Functional | pKd | = | 8.1 | 8.1 | - | 2 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm070487n | |||
118731356 | 118256 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 502 | 8 | 0 | 4 | 4.6 | O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409039 | 118256 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 502 | 8 | 0 | 4 | 4.6 | O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
4806 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
71768094 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
71768094.0 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
7351 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
9966051 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
9966051.0 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
CHEMBL2104993 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
DB09068 | 4008 | None | 55 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 3 | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | |||
118731351 | 118252 | None | 0 | Human | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 496 | 8 | 1 | 4 | 4.1 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409035 | 118252 | None | 0 | Human | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 496 | 8 | 1 | 4 | 4.1 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
118731356 | 118256 | None | 0 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 502 | 8 | 0 | 4 | 4.6 | O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409039 | 118256 | None | 0 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 502 | 8 | 0 | 4 | 4.6 | O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
118731351 | 118252 | None | 0 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 496 | 8 | 1 | 4 | 4.1 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409035 | 118252 | None | 0 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 496 | 8 | 1 | 4 | 4.1 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
240 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
2769 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
44279790 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
660 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
CHEMBL1729 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
CHEMBL560739 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
DB00604 | 944 | None | 25 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 22 | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | |||
4223 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -562 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
6918314 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -562 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
6918314.0 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -562 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
7427 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -562 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
CHEMBL439849 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -562 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | |||
DB06684 | 3992 | None | 57 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -562 | 17 | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
135398737 | 958 | None | 57 | Human | Binding | pAC50 | = | 7.0 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
135398737.0 | 958 | None | 57 | Human | Binding | pAC50 | = | 7.0 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
38 | 958 | None | 57 | Human | Binding | pAC50 | = | 7.0 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
722 | 958 | None | 57 | Human | Binding | pAC50 | = | 7.0 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pAC50 | = | 7.0 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
DB00363 | 958 | None | 57 | Human | Binding | pAC50 | = | 7.0 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
3158 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
3158.0 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1628227 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
DB01142 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
2585 | 803 | None | 59 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
2585.0 | 803 | None | 59 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
522 | 803 | None | 59 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
551 | 803 | None | 59 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
CHEMBL723 | 803 | None | 59 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
DB01136 | 803 | None | 59 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 22 | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
2247 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | |||
249 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | |||
2603 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL296419 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | |||
DB00637 | 505 | None | 55 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 41 | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1038/s41467-023-40064-9 | |||
2284 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.7 | 5.7 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
4926 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.7 | 5.7 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
7281 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.7 | 5.7 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL564 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.7 | 5.7 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
DB00420 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.7 | 5.7 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
2337 | 3256 | None | 51 | Human | Binding | pAC50 | = | 5.7 | 5.7 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
50 | 3256 | None | 51 | Human | Binding | pAC50 | = | 5.7 | 5.7 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
5002 | 3256 | None | 51 | Human | Binding | pAC50 | = | 5.7 | 5.7 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
5002.0 | 3256 | None | 51 | Human | Binding | pAC50 | = | 5.7 | 5.7 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL716 | 3256 | None | 51 | Human | Binding | pAC50 | = | 5.7 | 5.7 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
DB01224 | 3256 | None | 51 | Human | Binding | pAC50 | = | 5.7 | 5.7 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
1890 | 2759 | None | 31 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -8 | 26 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
4449 | 2759 | None | 31 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -8 | 26 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
7247 | 2759 | None | 31 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -8 | 26 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
CHEMBL623 | 2759 | None | 31 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -8 | 26 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
DB01149 | 2759 | None | 31 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -8 | 26 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.1038/s41467-023-40064-9 | |||
212 | 3806 | None | 35 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -7 | 25 | ChEMBL | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 10.1038/s41467-023-40064-9 | |||
2639 | 3806 | None | 35 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -7 | 25 | ChEMBL | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 10.1038/s41467-023-40064-9 | |||
941651 | 3806 | None | 35 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -7 | 25 | ChEMBL | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 10.1038/s41467-023-40064-9 | |||
941651.0 | 3806 | None | 35 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -7 | 25 | ChEMBL | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL1201 | 3806 | None | 35 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -7 | 25 | ChEMBL | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 10.1038/s41467-023-40064-9 | |||
DB01623 | 3806 | None | 35 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -7 | 25 | ChEMBL | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 10.1038/s41467-023-40064-9 | |||
2389 | 3331 | None | 72 | Human | Binding | pAC50 | = | 7.5 | 7.5 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1038/s41467-023-40064-9 | |||
5073 | 3331 | None | 72 | Human | Binding | pAC50 | = | 7.5 | 7.5 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1038/s41467-023-40064-9 | |||
5073.0 | 3331 | None | 72 | Human | Binding | pAC50 | = | 7.5 | 7.5 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1038/s41467-023-40064-9 | |||
96 | 3331 | None | 72 | Human | Binding | pAC50 | = | 7.5 | 7.5 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pAC50 | = | 7.5 | 7.5 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1038/s41467-023-40064-9 | |||
DB00734 | 3331 | None | 72 | Human | Binding | pAC50 | = | 7.5 | 7.5 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1038/s41467-023-40064-9 | |||
135 | 2532 | None | 33 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1038/s41467-023-40064-9 | |||
1796 | 2532 | None | 33 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1038/s41467-023-40064-9 | |||
4184 | 2532 | None | 33 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1038/s41467-023-40064-9 | |||
4184.0 | 2532 | None | 33 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL6437 | 2532 | None | 33 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1038/s41467-023-40064-9 | |||
DB06148 | 2532 | None | 33 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1038/s41467-023-40064-9 | |||
2543 | 3707 | None | 46 | Human | Binding | pAC50 | = | 5.3 | 5.3 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1038/s41467-023-40064-9 | |||
5358 | 3707 | None | 46 | Human | Binding | pAC50 | = | 5.3 | 5.3 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1038/s41467-023-40064-9 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pAC50 | = | 5.3 | 5.3 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1038/s41467-023-40064-9 | |||
54 | 3707 | None | 46 | Human | Binding | pAC50 | = | 5.3 | 5.3 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pAC50 | = | 5.3 | 5.3 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1038/s41467-023-40064-9 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pAC50 | = | 5.3 | 5.3 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1038/s41467-023-40064-9 | |||
191 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -41 | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
201 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -41 | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
2170 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -41 | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
2170.0 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -41 | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1113 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -41 | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
DB00543 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -41 | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
135398745 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
47 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
DB00334 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.2 | 6.2 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
1400 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
3658 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
3658.0 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
7199 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
91513 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL896 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
DB00557 | 1957 | None | 46 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 3 | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
2726 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | |||
2726.0 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | |||
621 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | |||
83 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | |||
DB00477 | 919 | None | 48 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | |||
1613 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -19 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
205 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -19 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
3964 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -19 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
3964.0 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -19 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL831 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -19 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
DB00408 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.1 | 6.1 | -19 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
135409453 | 3773 | None | 26 | Human | Binding | pAC50 | = | 6.1 | 6.1 | - | 19 | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
226 | 3773 | None | 26 | Human | Binding | pAC50 | = | 6.1 | 6.1 | - | 19 | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
CHEMBL76370 | 3773 | None | 26 | Human | Binding | pAC50 | = | 6.1 | 6.1 | - | 19 | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
1353 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.1 | 5.1 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
3559 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.1 | 5.1 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.1 | 5.1 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
86 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.1 | 5.1 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.1 | 5.1 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pAC50 | = | 5.1 | 5.1 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
392622 | 56328 | None | 57 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 4 | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL163 | 56328 | None | 57 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 4 | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
4106 | 2502 | None | 21 | Human | Binding | pEC50 | = | 9.2 | 9.2 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/np058114h | |||
5358812 | 2502 | None | 21 | Human | Binding | pEC50 | = | 9.2 | 9.2 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/np058114h | |||
89 | 2502 | None | 21 | Human | Binding | pEC50 | = | 9.2 | 9.2 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/np058114h | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pEC50 | = | 9.2 | 9.2 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/np058114h | |||
5 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.3 | 8.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
5202 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.3 | 8.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.3 | 8.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
DB08839 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.3 | 8.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
5 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.2 | 8.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
5202 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.2 | 8.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.2 | 8.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
DB08839 | 139 | None | 45 | Human | Binding | pEC50 | = | 8.2 | 8.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2019.07.046 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.03.006 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2016.11.014 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
72548703 | 161661 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
CHEMBL4128926 | 161661 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmc.2013.03.016 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm701575k | |||
11430418 | 18793 | None | 9 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 432 | 6 | 1 | 7 | 2.5 | Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 | 10.1021/jm1002292 | |||
CHEMBL1278088 | 18793 | None | 9 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 432 | 6 | 1 | 7 | 2.5 | Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 | 10.1021/jm1002292 | |||
44452114 | 160897 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL411442 | 160897 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452114 | 160897 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL411442 | 160897 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
72197486 | 102558 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 364 | 4 | 2 | 4 | 4.2 | Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL2393245 | 102558 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 364 | 4 | 2 | 4 | 4.2 | Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL3040361 | 102558 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 364 | 4 | 2 | 4 | 4.2 | Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
49864602 | 15671 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 373 | 5 | 0 | 4 | 3.0 | CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1222138 | 15671 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 373 | 5 | 0 | 4 | 3.0 | CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2010.06.150 | |||
44576978 | 187378 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 3.5 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL492793 | 187378 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 3.5 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
72197485 | 102544 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 4 | 2 | 4 | 3.6 | Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL2393244 | 102544 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 4 | 2 | 4 | 3.6 | Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL3040288 | 102544 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 348 | 4 | 2 | 4 | 3.6 | Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
42635388 | 187804 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 471 | 8 | 1 | 5 | 3.6 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495250 | 187804 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 471 | 8 | 1 | 5 | 3.6 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44452277 | 96132 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260073 | 96132 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452245 | 96199 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260514 | 96199 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452251 | 96288 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260901 | 96288 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
44452219 | 161331 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL411868 | 161331 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
54576142 | 66516 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 485 | 7 | 1 | 5 | 4.7 | Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | |||
CHEMBL1852341 | 66516 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 485 | 7 | 1 | 5 | 4.7 | Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | |||
CHEMBL3216098 | 66516 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 485 | 7 | 1 | 5 | 4.7 | Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | |||
24882509 | 96292 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260907 | 96292 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452277 | 96132 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260073 | 96132 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452245 | 96199 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260514 | 96199 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
46232586 | 203379 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 473 | 9 | 0 | 4 | 4.6 | O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601659 | 203379 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 473 | 9 | 0 | 4 | 4.6 | O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
44452251 | 96288 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260901 | 96288 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
44452219 | 161331 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL411868 | 161331 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
135 | 2532 | None | 33 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | |||
1796 | 2532 | None | 33 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | |||
4184 | 2532 | None | 33 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | |||
4184.0 | 2532 | None | 33 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | |||
CHEMBL6437 | 2532 | None | 33 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | |||
DB06148 | 2532 | None | 33 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -83 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | |||
46232818 | 203438 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 463 | 9 | 0 | 4 | 4.5 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602060 | 203438 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 463 | 9 | 0 | 4 | 4.5 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
11113605 | 10510 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
CHEMBL116735 | 10510 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
44451927 | 96080 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259776 | 96080 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452038 | 96294 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260969 | 96294 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
155561990 | 175815 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 557 | 11 | 1 | 7 | 4.5 | CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL4582321 | 175815 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 557 | 11 | 1 | 7 | 4.5 | CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2019.111705 | |||
24882509 | 96292 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260907 | 96292 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
42635204 | 187865 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 477 | 7 | 1 | 4 | 4.3 | O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495678 | 187865 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 477 | 7 | 1 | 4 | 4.3 | O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
46232860 | 203518 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 494 | 10 | 0 | 6 | 3.9 | COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602677 | 203518 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 494 | 10 | 0 | 6 | 3.9 | COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1 | 10.1016/j.bmc.2009.12.067 | |||
141 | 1427 | None | 18 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
6089 | 1427 | None | 18 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
CHEMBL12420 | 1427 | None | 18 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
DB01488 | 1427 | None | 18 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
44451927 | 96080 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259776 | 96080 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452038 | 96294 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260969 | 96294 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
46232771 | 203312 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 443 | 10 | 0 | 5 | 3.3 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601249 | 203312 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 443 | 10 | 0 | 5 | 3.3 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
10067306 | 201322 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 363 | 5 | 0 | 5 | 3.1 | CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 | 10.1016/j.bmc.2009.05.055 | |||
CHEMBL584046 | 201322 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 363 | 5 | 0 | 5 | 3.1 | CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 | 10.1016/j.bmc.2009.05.055 | |||
46232622 | 203173 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 505 | 9 | 0 | 4 | 5.6 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL600012 | 203173 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 505 | 9 | 0 | 4 | 5.6 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
42635387 | 187798 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 477 | 7 | 1 | 4 | 4.6 | O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495212 | 187798 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 477 | 7 | 1 | 4 | 4.6 | O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
46232773 | 203408 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 511 | 10 | 0 | 5 | 4.3 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601855 | 203408 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 511 | 10 | 0 | 5 | 4.3 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
44452278 | 96133 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260074 | 96133 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452039 | 96295 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260970 | 96295 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452278 | 96133 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260074 | 96133 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452039 | 96295 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260970 | 96295 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44451930 | 95816 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL258524 | 95816 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44451930 | 95816 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL258524 | 95816 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
10472158 | 199281 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 335 | 4 | 1 | 5 | 2.5 | NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 | 10.1016/j.bmc.2009.05.055 | |||
CHEMBL565745 | 199281 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 335 | 4 | 1 | 5 | 2.5 | NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21 | 10.1016/j.bmc.2009.05.055 | |||
44452223 | 96044 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259625 | 96044 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
42388965 | 187641 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 427 | 7 | 1 | 4 | 3.5 | O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL494428 | 187641 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 427 | 7 | 1 | 4 | 3.5 | O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
44452223 | 96044 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259625 | 96044 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
53320009 | 56679 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1 | 10.1016/j.bmcl.2010.12.007 | |||
CHEMBL1642116 | 56679 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1 | 10.1016/j.bmcl.2010.12.007 | |||
169713 | 80192 | None | 12 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 309 | 3 | 2 | 2 | 2.6 | CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1 | 10.1016/j.bmcl.2009.09.002 | |||
CHEMBL21343 | 80192 | None | 12 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 309 | 3 | 2 | 2 | 2.6 | CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1 | 10.1016/j.bmcl.2009.09.002 | |||
11047568 | 10058 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 396 | 9 | 0 | 4 | 4.0 | CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL115249 | 10058 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 396 | 9 | 0 | 4 | 4.0 | CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 | 10.1021/jm010878g | |||
10885636 | 111079 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL326263 | 111079 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
46232732 | 203382 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 431 | 9 | 0 | 4 | 3.4 | O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601673 | 203382 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 431 | 9 | 0 | 4 | 3.4 | O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
44452276 | 160028 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL410722 | 160028 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452276 | 160028 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL410722 | 160028 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
12 | 1553 | None | 11 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -13 | 7 | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1016/j.bmcl.2005.06.067 | |||
6918513 | 1553 | None | 11 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -13 | 7 | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1016/j.bmcl.2005.06.067 | |||
CHEMBL267615 | 1553 | None | 11 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -13 | 7 | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1016/j.bmcl.2005.06.067 | |||
46232653 | 203476 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 523 | 9 | 0 | 4 | 5.8 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602284 | 203476 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 523 | 9 | 0 | 4 | 5.8 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
46232730 | 203348 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 463 | 9 | 0 | 4 | 4.5 | O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601457 | 203348 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 463 | 9 | 0 | 4 | 4.5 | O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
72197484 | 102549 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 330 | 4 | 2 | 4 | 3.5 | c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL2393243 | 102549 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 330 | 4 | 2 | 4 | 3.5 | c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL3040324 | 102549 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 330 | 4 | 2 | 4 | 3.5 | c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1 | 10.1016/j.ejmech.2013.02.020 | |||
18180076 | 15609 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 381 | 4 | 1 | 4 | 3.4 | CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1221497 | 15609 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 381 | 4 | 1 | 4 | 3.4 | CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
44452247 | 96240 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.9 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260706 | 96240 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.9 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452115 | 96431 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261742 | 96431 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44451980 | 156112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL406221 | 156112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452115 | 96431 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261742 | 96431 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44451980 | 156112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL406221 | 156112 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452247 | 96240 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.9 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260706 | 96240 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.9 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
46232690 | 203417 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 574 | 9 | 0 | 5 | 6.0 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601886 | 203417 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 574 | 9 | 0 | 5 | 6.0 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
155568606 | 176212 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -3 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL4591601 | 176212 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -3 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC | 10.1016/j.bmc.2019.07.046 | |||
155568606 | 176212 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -3 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL4591601 | 176212 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -3 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC | 10.1016/j.bmc.2019.07.046 | |||
11957735 | 202477 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 350 | 4 | 1 | 5 | 4.0 | CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1 | 10.1016/j.bmc.2009.07.007 | |||
CHEMBL595449 | 202477 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 350 | 4 | 1 | 5 | 4.0 | CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1 | 10.1016/j.bmc.2009.07.007 | |||
46232589 | 203269 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 515 | 11 | 0 | 6 | 4.5 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL600822 | 203269 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 515 | 11 | 0 | 6 | 4.5 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
19426635 | 208051 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 280 | 2 | 1 | 3 | 3.1 | CNCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | |||
CHEMBL81485 | 208051 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 280 | 2 | 1 | 3 | 3.1 | CNCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | |||
73351903 | 89729 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 360 | 3 | 2 | 4 | 3.1 | Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376484 | 89729 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 360 | 3 | 2 | 4 | 3.1 | Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
46232819 | 203611 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 493 | 10 | 0 | 5 | 4.5 | COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL603272 | 203611 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 493 | 10 | 0 | 5 | 4.5 | COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2009.12.067 | |||
44452166 | 95862 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL258785 | 95862 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452166 | 95862 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL258785 | 95862 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 543 | 10 | 1 | 7 | 4.1 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452005 | 95998 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259407 | 95998 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44451954 | 160469 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL411105 | 160469 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452005 | 95998 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259407 | 95998 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44451954 | 160469 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL411105 | 160469 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
46232559 | 203551 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 505 | 9 | 0 | 4 | 5.6 | O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602882 | 203551 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 505 | 9 | 0 | 4 | 5.6 | O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
44452196 | 96082 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259827 | 96082 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
44451953 | 96332 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261149 | 96332 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452080 | 155867 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL405892 | 155867 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452144 | 96353 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261232 | 96353 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
5 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0205102 | |||
5202 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0205102 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0205102 | |||
DB08839 | 139 | None | 45 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0205102 | |||
3233 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
3247 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
6604889 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
3233 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
3247 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
6604889 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2019.07.046 | |||
42388639 | 188160 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | -4 | 6 | ChEMBL | 439 | 8 | 1 | 5 | 3.3 | COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL497749 | 188160 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | -4 | 6 | ChEMBL | 439 | 8 | 1 | 5 | 3.3 | COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2008.04.023 | |||
44452170 | 167085 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL428781 | 167085 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452196 | 96082 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259827 | 96082 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
44451953 | 96332 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261149 | 96332 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
44452080 | 155867 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL405892 | 155867 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452144 | 96353 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261232 | 96353 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
51003551 | 56686 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 449 | 3 | 0 | 5 | 3.8 | CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.12.007 | |||
CHEMBL1642123 | 56686 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 449 | 3 | 0 | 5 | 3.8 | CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.12.007 | |||
10907460 | 9830 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL113956 | 9830 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
49864292 | 15602 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 471 | 6 | 0 | 4 | 5.0 | CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1221452 | 15602 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 471 | 6 | 0 | 4 | 5.0 | CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
49864724 | 15699 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 409 | 5 | 0 | 4 | 3.8 | CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1222364 | 15699 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 409 | 5 | 0 | 4 | 3.8 | CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.06.150 | |||
44452274 | 96289 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260902 | 96289 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452170 | 167085 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL428781 | 167085 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452274 | 96289 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260902 | 96289 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
11730467 | 11032 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
CHEMBL117537 | 11032 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
155531753 | 171749 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | 548 | 11 | 1 | 7 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL4465959 | 171749 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | 548 | 11 | 1 | 7 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 | 10.1016/j.bmc.2019.07.046 | |||
155531753 | 171749 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | 548 | 11 | 1 | 7 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL4465959 | 171749 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -1 | 2 | ChEMBL | 548 | 11 | 1 | 7 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 | 10.1016/j.bmc.2019.07.046 | |||
44451929 | 96116 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260003 | 96116 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44451929 | 96116 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260003 | 96116 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
42635570 | 187477 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 439 | 8 | 1 | 5 | 3.3 | COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL493416 | 187477 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 439 | 8 | 1 | 5 | 3.3 | COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1 | 10.1016/j.bmc.2008.04.023 | |||
46232729 | 203913 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 574 | 9 | 0 | 5 | 6.3 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL604952 | 203913 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 574 | 9 | 0 | 5 | 6.3 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
44452139 | 96263 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260804 | 96263 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmc.2007.11.049 | |||
44452139 | 96263 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260804 | 96263 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452302 | 96324 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261100 | 96324 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
46232689 | 203416 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 536 | 10 | 0 | 6 | 5.0 | COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601885 | 203416 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 536 | 10 | 0 | 6 | 5.0 | COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1 | 10.1016/j.bmc.2009.12.067 | |||
44452302 | 96324 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261100 | 96324 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44451957 | 158588 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 515 | 8 | 1 | 7 | 3.4 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL409107 | 158588 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 515 | 8 | 1 | 7 | 3.4 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44451957 | 158588 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 515 | 8 | 1 | 7 | 3.4 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL409107 | 158588 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 515 | 8 | 1 | 7 | 3.4 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
11304851 | 154695 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 426 | 4 | 3 | 8 | 3.7 | O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2 | 10.1016/j.bmcl.2007.05.011 | |||
CHEMBL399203 | 154695 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 426 | 4 | 3 | 8 | 3.7 | O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2 | 10.1016/j.bmcl.2007.05.011 | |||
44452143 | 96352 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 525 | 10 | 1 | 7 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261231 | 96352 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 525 | 10 | 1 | 7 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452143 | 96352 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 525 | 10 | 1 | 7 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261231 | 96352 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 525 | 10 | 1 | 7 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44451952 | 160467 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL411104 | 160467 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
44451952 | 160467 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL411104 | 160467 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
44452006 | 157593 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL407966 | 157593 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452006 | 157593 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL407966 | 157593 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452037 | 96250 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260756 | 96250 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452273 | 158229 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL408717 | 158229 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
46866711 | 15677 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 423 | 5 | 0 | 4 | 4.2 | CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1222234 | 15677 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 423 | 5 | 0 | 4 | 4.2 | CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12 | 10.1016/j.bmcl.2010.06.150 | |||
42388975 | 192830 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 407 | 8 | 1 | 5 | 2.3 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL522006 | 192830 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 407 | 8 | 1 | 5 | 2.3 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44452037 | 96250 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260756 | 96250 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452273 | 158229 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL408717 | 158229 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
4106 | 2502 | None | 21 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2007.11.049 | |||
5358812 | 2502 | None | 21 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2007.11.049 | |||
89 | 2502 | None | 21 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2007.11.049 | |||
4223 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
6918314 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
6918314.0 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
7427 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
CHEMBL439849 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
DB06684 | 3992 | None | 57 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 17 | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | |||
10131112 | 1552 | None | 18 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
8428 | 1552 | None | 18 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
CHEMBL364005 | 1552 | None | 18 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | |||
49864289 | 15599 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 435 | 6 | 0 | 4 | 4.2 | CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1221449 | 15599 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 435 | 6 | 0 | 4 | 4.2 | CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
73347306 | 89728 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 230 | 1 | 2 | 1 | 3.0 | Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376483 | 89728 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 230 | 1 | 2 | 1 | 3.0 | Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
46232772 | 203314 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 473 | 11 | 0 | 6 | 3.3 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601250 | 203314 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 473 | 11 | 0 | 6 | 3.3 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
46232977 | 203653 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 453 | 8 | 1 | 5 | 3.7 | COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL603499 | 203653 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 453 | 8 | 1 | 5 | 3.7 | COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2009.12.067 | |||
42389293 | 187640 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 439 | 8 | 1 | 5 | 3.3 | COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL494427 | 187640 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 439 | 8 | 1 | 5 | 3.3 | COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
45278805 | 7452 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 484 | 7 | 1 | 4 | 5.2 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C | 10.1016/j.bmcl.2010.01.093 | |||
CHEMBL1086754 | 7452 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 484 | 7 | 1 | 4 | 5.2 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C | 10.1016/j.bmcl.2010.01.093 | |||
46232731 | 203349 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 481 | 9 | 0 | 4 | 4.3 | O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601458 | 203349 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 481 | 9 | 0 | 4 | 4.3 | O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
42635029 | 187539 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL493810 | 187539 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
46232820 | 203309 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 531 | 9 | 0 | 4 | 5.5 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601220 | 203309 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 531 | 9 | 0 | 4 | 5.5 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
44452357 | 95959 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259236 | 95959 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452118 | 96406 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.6 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261573 | 96406 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.6 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
46232975 | 203554 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 482 | 9 | 0 | 5 | 4.0 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602889 | 203554 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 482 | 9 | 0 | 5 | 4.0 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
44452357 | 95959 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259236 | 95959 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452118 | 96406 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.6 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261573 | 96406 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 549 | 8 | 1 | 6 | 4.6 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
46232978 | 203576 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 491 | 7 | 1 | 4 | 4.7 | CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL603093 | 203576 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 491 | 7 | 1 | 4 | 4.7 | CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmc.2009.12.067 | |||
44451931 | 95817 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL258525 | 95817 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
11166042 | 166464 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | 2 | 3 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL427518 | 166464 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | 2 | 3 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44451931 | 95817 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL258525 | 95817 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
73351905 | 89736 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 288 | 2 | 2 | 1 | 4.5 | Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376491 | 89736 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 288 | 2 | 2 | 1 | 4.5 | Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
42635571 | 187866 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 421 | 8 | 1 | 5 | 2.7 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495685 | 187866 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 421 | 8 | 1 | 5 | 2.7 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
42635572 | 187903 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 8 | 1 | 5 | 2.6 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495890 | 187903 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 8 | 1 | 5 | 2.6 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
42635028 | 193324 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 3.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL523519 | 193324 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 3.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
49864723 | 15698 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 423 | 6 | 0 | 4 | 4.2 | CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1222363 | 15698 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 423 | 6 | 0 | 4 | 4.2 | CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.06.150 | |||
44452329 | 158830 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL409358 | 158830 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452329 | 158830 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL409358 | 158830 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
45278882 | 7454 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 512 | 9 | 1 | 4 | 6.1 | CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C | 10.1016/j.bmcl.2010.01.093 | |||
CHEMBL1086756 | 7454 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 512 | 9 | 1 | 4 | 6.1 | CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C | 10.1016/j.bmcl.2010.01.093 | |||
46232654 | 203477 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 506 | 9 | 0 | 5 | 5.0 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602285 | 203477 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 506 | 9 | 0 | 5 | 5.0 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
44452197 | 96126 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260029 | 96126 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452081 | 96229 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260648 | 96229 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452008 | 95999 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259408 | 95999 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452197 | 96126 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260029 | 96126 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
44452081 | 96229 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260648 | 96229 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452171 | 168800 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL436700 | 168800 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
46232691 | 203418 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 524 | 9 | 0 | 5 | 5.2 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601887 | 203418 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 524 | 9 | 0 | 5 | 5.2 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
11761059 | 10053 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 394 | 4 | 1 | 8 | 3.1 | O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2 | 10.1021/jm010878g | |||
CHEMBL115229 | 10053 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 394 | 4 | 1 | 8 | 3.1 | O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2 | 10.1021/jm010878g | |||
49864722 | 15697 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 395 | 4 | 0 | 4 | 3.4 | CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
CHEMBL1222362 | 15697 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 395 | 4 | 0 | 4 | 3.4 | CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1 | 10.1016/j.bmcl.2010.06.150 | |||
44452328 | 96134 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260076 | 96134 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452249 | 158642 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL409157 | 158642 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452171 | 168800 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL436700 | 168800 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 511 | 9 | 1 | 7 | 3.6 | CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452328 | 96134 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260076 | 96134 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 5.1 | O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452249 | 158642 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL409157 | 158642 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 515 | 8 | 1 | 6 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
46232560 | 203474 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 523 | 9 | 0 | 4 | 5.5 | O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602274 | 203474 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 523 | 9 | 0 | 4 | 5.5 | O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
45109862 | 7436 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 470 | 7 | 2 | 3 | 5.2 | Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmcl.2010.01.093 | |||
CHEMBL1086626 | 7436 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 470 | 7 | 2 | 3 | 5.2 | Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmcl.2010.01.093 | |||
44452222 | 96002 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259415 | 96002 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
44452222 | 96002 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259415 | 96002 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
44452117 | 96405 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261572 | 96405 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
42389467 | 187542 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 407 | 8 | 1 | 5 | 2.3 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL493816 | 187542 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 407 | 8 | 1 | 5 | 2.3 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44452217 | 95906 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259001 | 95906 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452117 | 96405 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261572 | 96405 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
36418162 | 187668 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 423 | 8 | 1 | 4 | 3.3 | O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL494573 | 187668 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 423 | 8 | 1 | 4 | 3.3 | O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
637308 | 184014 | None | 30 | Human | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 314 | 6 | 2 | 5 | 2.9 | COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O | 10.1021/np050301s | |||
CHEMBL481245 | 184014 | None | 30 | Human | Binding | pIC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 314 | 6 | 2 | 5 | 2.9 | COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O | 10.1021/np050301s | |||
10337743 | 4076 | None | 15 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 347 | 5 | 0 | 5 | 2.6 | CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C | 10.1016/j.bmc.2009.05.055 | |||
8429 | 4076 | None | 15 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 347 | 5 | 0 | 5 | 2.6 | CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C | 10.1016/j.bmc.2009.05.055 | |||
CHEMBL571858 | 4076 | None | 15 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 347 | 5 | 0 | 5 | 2.6 | CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C | 10.1016/j.bmc.2009.05.055 | |||
44452217 | 95906 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259001 | 95906 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452007 | 95951 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259199 | 95951 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
73354882 | 89727 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 290 | 1 | 2 | 1 | 3.6 | Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376482 | 89727 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 290 | 1 | 2 | 1 | 3.6 | Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
44452007 | 95951 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259199 | 95951 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
46232858 | 203239 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 481 | 9 | 0 | 4 | 4.6 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL600606 | 203239 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 481 | 9 | 0 | 4 | 4.6 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
45278883 | 7651 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 553 | 8 | 1 | 5 | 5.8 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1 | 10.1016/j.bmcl.2010.01.093 | |||
CHEMBL1088313 | 7651 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 553 | 8 | 1 | 5 | 5.8 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1 | 10.1016/j.bmcl.2010.01.093 | |||
72197668 | 102550 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 360 | 5 | 2 | 5 | 3.5 | COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL2393246 | 102550 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 360 | 5 | 2 | 5 | 3.5 | COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
CHEMBL3040325 | 102550 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 360 | 5 | 2 | 5 | 3.5 | COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1 | 10.1016/j.ejmech.2013.02.020 | |||
44451959 | 96333 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261151 | 96333 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44451984 | 96417 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261653 | 96417 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
46232623 | 203195 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 535 | 10 | 0 | 5 | 5.6 | COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL600210 | 203195 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 535 | 10 | 0 | 5 | 5.6 | COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmc.2009.12.067 | |||
46232770 | 203298 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 458 | 10 | 0 | 6 | 3.2 | O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601037 | 203298 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 458 | 10 | 0 | 6 | 3.2 | O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
44451959 | 96333 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261151 | 96333 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44451984 | 96417 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261653 | 96417 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 513 | 7 | 1 | 6 | 4.0 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44451986 | 159458 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL410042 | 159458 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44451986 | 159458 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL410042 | 159458 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 501 | 7 | 1 | 6 | 3.9 | O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
10407367 | 199249 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 379 | 5 | 0 | 5 | 3.6 | CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21 | 10.1016/j.bmc.2009.05.055 | |||
CHEMBL565552 | 199249 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 379 | 5 | 0 | 5 | 3.6 | CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21 | 10.1016/j.bmc.2009.05.055 | |||
44452008 | 95999 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259408 | 95999 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 533 | 8 | 1 | 6 | 4.4 | O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
45278886 | 7652 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 564 | 8 | 1 | 4 | 6.8 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1 | 10.1016/j.bmcl.2010.01.093 | |||
CHEMBL1088314 | 7652 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 564 | 8 | 1 | 4 | 6.8 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1 | 10.1016/j.bmcl.2010.01.093 | |||
46233014 | 203475 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 441 | 7 | 1 | 4 | 3.9 | CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602279 | 203475 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 441 | 7 | 1 | 4 | 3.9 | CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmc.2009.12.067 | |||
42389457 | 187839 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 427 | 7 | 1 | 4 | 3.5 | O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495445 | 187839 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 427 | 7 | 1 | 4 | 3.5 | O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
44452193 | 96123 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260022 | 96123 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44451982 | 96378 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261434 | 96378 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
16 | 2253 | None | 10 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
9847194 | 2253 | None | 10 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
CHEMBL313714 | 2253 | None | 10 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 462 | 9 | 3 | 6 | 3.6 | OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9910021 | |||
44452193 | 96123 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260022 | 96123 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 555 | 11 | 1 | 8 | 4.0 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44451982 | 96378 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261434 | 96378 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
46700867 | 176094 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 377 | 14 | 1 | 4 | 5.0 | CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 | 10.1016/j.ejmech.2019.04.009 | |||
CHEMBL4588956 | 176094 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 377 | 14 | 1 | 4 | 5.0 | CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 | 10.1016/j.ejmech.2019.04.009 | |||
42635205 | 187901 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 477 | 7 | 1 | 4 | 4.3 | O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL495884 | 187901 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 477 | 7 | 1 | 4 | 4.3 | O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
46232588 | 203414 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 485 | 10 | 0 | 5 | 4.5 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601872 | 203414 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 485 | 10 | 0 | 5 | 4.5 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
42635389 | 187475 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 433 | 9 | 1 | 6 | 2.6 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL493402 | 187475 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 433 | 9 | 1 | 6 | 2.6 | COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44452275 | 96290 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260903 | 96290 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.bmc.2007.11.049 | |||
44452298 | 96365 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261337 | 96365 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452275 | 96290 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260903 | 96290 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C | 10.1016/j.ejmech.2008.09.050 | |||
44452298 | 96365 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261337 | 96365 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
46232861 | 203550 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 532 | 9 | 0 | 5 | 4.9 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602878 | 203550 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 532 | 9 | 0 | 5 | 4.9 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
54577891 | 66596 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.3 | Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | |||
CHEMBL1852516 | 66596 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.3 | Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | |||
CHEMBL3216758 | 66596 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.3 | Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | |||
44451979 | 96377 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261433 | 96377 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
72198754 | 90914 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 443 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL2392349 | 90914 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 443 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 | 10.1016/j.ejmech.2013.01.044 | |||
53320010 | 56680 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2010.12.007 | |||
CHEMBL1642117 | 56680 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2010.12.007 | |||
44451979 | 96377 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261433 | 96377 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
185617 | 186660 | None | 53 | Human | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 462 | 4 | 7 | 11 | -0.2 | O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O | 10.1021/np0205102 | |||
CHEMBL487805 | 186660 | None | 53 | Human | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 462 | 4 | 7 | 11 | -0.2 | O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O | 10.1021/np0205102 | |||
44452279 | 161382 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL412153 | 161382 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452279 | 161382 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL412153 | 161382 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
44452331 | 96160 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 481 | 8 | 1 | 6 | 3.6 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260249 | 96160 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 481 | 8 | 1 | 6 | 3.6 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452331 | 96160 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 481 | 8 | 1 | 6 | 3.6 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260249 | 96160 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 481 | 8 | 1 | 6 | 3.6 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
46232976 | 203575 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 423 | 7 | 1 | 4 | 3.7 | CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL603092 | 203575 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 423 | 7 | 1 | 4 | 3.7 | CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmc.2009.12.067 | |||
10949380 | 164118 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 399 | 3 | 1 | 6 | 4.3 | Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1 | 10.1021/jm010878g | |||
CHEMBL420863 | 164118 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 399 | 3 | 1 | 6 | 4.3 | Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1 | 10.1021/jm010878g | |||
46232620 | 203293 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 553 | 10 | 0 | 5 | 5.5 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601022 | 203293 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 553 | 10 | 0 | 5 | 5.5 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
44452010 | 96043 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 485 | 7 | 1 | 6 | 3.4 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259619 | 96043 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 485 | 7 | 1 | 6 | 3.4 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452141 | 96305 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261018 | 96305 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452010 | 96043 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 485 | 7 | 1 | 6 | 3.4 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259619 | 96043 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 485 | 7 | 1 | 6 | 3.4 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452141 | 96305 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261018 | 96305 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 9 | 1 | 7 | 3.9 | CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
42389129 | 193220 | None | 1 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL522694 | 193220 | None | 1 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmc.2008.04.023 | |||
73356443 | 89735 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 2 | 2 | 2 | 4.6 | Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
CHEMBL2376490 | 89735 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 2 | 2 | 2 | 4.6 | Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | |||
44452221 | 96001 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259414 | 96001 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
44452221 | 96001 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259414 | 96001 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 8 | 1 | 6 | 4.2 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452199 | 96124 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260023 | 96124 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452199 | 96124 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260023 | 96124 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
11071079 | 110656 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
CHEMBL325516 | 110656 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
44452332 | 96161 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 481 | 7 | 1 | 6 | 3.5 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260250 | 96161 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 481 | 7 | 1 | 6 | 3.5 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452362 | 96562 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 530 | 8 | 1 | 8 | 3.3 | O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL262589 | 96562 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 530 | 8 | 1 | 8 | 3.3 | O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452324 | 96291 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260906 | 96291 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452332 | 96161 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 481 | 7 | 1 | 6 | 3.5 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260250 | 96161 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 481 | 7 | 1 | 6 | 3.5 | Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452362 | 96562 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 530 | 8 | 1 | 8 | 3.3 | O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL262589 | 96562 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 530 | 8 | 1 | 8 | 3.3 | O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452324 | 96291 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260906 | 96291 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452327 | 96325 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261102 | 96325 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
46232859 | 203240 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 464 | 9 | 0 | 5 | 3.8 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL600607 | 203240 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 464 | 9 | 0 | 5 | 3.8 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1 | 10.1016/j.bmc.2009.12.067 | |||
44452327 | 96325 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261102 | 96325 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
10937901 | 9912 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 385 | 3 | 1 | 6 | 4.0 | Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1 | 10.1021/jm010878g | |||
CHEMBL114379 | 9912 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 385 | 3 | 1 | 6 | 4.0 | Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1 | 10.1021/jm010878g | |||
44452040 | 96296 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260971 | 96296 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452041 | 96340 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261187 | 96340 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452040 | 96296 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260971 | 96296 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452041 | 96340 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261187 | 96340 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 517 | 8 | 1 | 6 | 3.9 | O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452243 | 158640 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL409156 | 158640 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452243 | 158640 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL409156 | 158640 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 559 | 10 | 1 | 8 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452224 | 96045 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL259626 | 96045 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452224 | 96045 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL259626 | 96045 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 497 | 8 | 1 | 7 | 3.2 | COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452246 | 96239 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL260705 | 96239 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44342270 | 9932 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 355 | 3 | 1 | 4 | 4.5 | Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1 | 10.1021/jm010878g | |||
CHEMBL114484 | 9932 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 355 | 3 | 1 | 4 | 4.5 | Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1 | 10.1021/jm010878g | |||
44452246 | 96239 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL260705 | 96239 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
46232587 | 204041 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 500 | 10 | 0 | 6 | 4.4 | O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL605582 | 204041 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 500 | 10 | 0 | 6 | 4.4 | O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
46232652 | 203447 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 573 | 9 | 0 | 4 | 6.6 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL602087 | 203447 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 573 | 9 | 0 | 4 | 6.6 | O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1 | 10.1016/j.bmc.2009.12.067 | |||
42635027 | 187503 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 3.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL493625 | 187503 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 3.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44452042 | 160258 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 509 | 8 | 1 | 7 | 3.4 | CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL410922 | 160258 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 509 | 8 | 1 | 7 | 3.4 | CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
141 | 1427 | None | 18 | Human | Binding | pIC50 | = | 7.1 | 7.1 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
6089 | 1427 | None | 18 | Human | Binding | pIC50 | = | 7.1 | 7.1 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
CHEMBL12420 | 1427 | None | 18 | Human | Binding | pIC50 | = | 7.1 | 7.1 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
DB01488 | 1427 | None | 18 | Human | Binding | pIC50 | = | 7.1 | 7.1 | 1 | 28 | ChEMBL | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | 10.1021/acsmedchemlett.3c00143 | |||
44452167 | 95903 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL258995 | 95903 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.ejmech.2008.09.050 | |||
44452042 | 160258 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 509 | 8 | 1 | 7 | 3.4 | CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL410922 | 160258 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 509 | 8 | 1 | 7 | 3.4 | CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452167 | 95903 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL258995 | 95903 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 573 | 11 | 1 | 8 | 4.2 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1 | 10.1016/j.bmc.2007.11.049 | |||
44452142 | 96306 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261019 | 96306 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
44452142 | 96306 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261019 | 96306 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 567 | 8 | 1 | 6 | 4.8 | O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452359 | 159460 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL410043 | 159460 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.bmc.2007.11.049 | |||
44452359 | 159460 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL410043 | 159460 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 1 | 7 | 3.8 | COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452082 | 159494 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL410075 | 159494 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
46232817 | 203412 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 461 | 10 | 0 | 5 | 3.4 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL601859 | 203412 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 461 | 10 | 0 | 5 | 3.4 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
44452082 | 159494 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL410075 | 159494 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 499 | 8 | 1 | 6 | 3.7 | O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
42389303 | 187540 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL493811 | 187540 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1 | 10.1016/j.bmc.2008.04.023 | |||
44452301 | 96323 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261099 | 96323 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44451985 | 96418 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 467 | 7 | 1 | 6 | 3.2 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261654 | 96418 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 467 | 7 | 1 | 6 | 3.2 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452301 | 96323 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261099 | 96323 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 527 | 8 | 1 | 6 | 4.4 | Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1 | 10.1016/j.bmc.2007.11.049 | |||
44451985 | 96418 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 467 | 7 | 1 | 6 | 3.2 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261654 | 96418 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 467 | 7 | 1 | 6 | 3.2 | O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1 | 10.1016/j.bmc.2007.11.049 | |||
14748689 | 187379 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 373 | 8 | 1 | 4 | 2.2 | O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1 | 10.1016/j.bmc.2008.04.023 | |||
CHEMBL492794 | 187379 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 373 | 8 | 1 | 4 | 2.2 | O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1 | 10.1016/j.bmc.2008.04.023 | |||
44452305 | 96362 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL261291 | 96362 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.bmc.2007.11.049 | |||
44452305 | 96362 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL261291 | 96362 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 6 | 3.8 | Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C | 10.1016/j.ejmech.2008.09.050 | |||
44452078 | 95892 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL258956 | 95892 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 | 10.1016/j.bmc.2007.11.049 | |||
44452078 | 95892 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL258956 | 95892 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1 | 10.1016/j.ejmech.2008.09.050 | |||
44452195 | 157159 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 | 10.1016/j.ejmech.2008.09.050 | |||
CHEMBL407411 | 157159 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 | 10.1016/j.ejmech.2008.09.050 | |||
44452195 | 157159 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 | 10.1016/j.bmc.2007.11.049 | |||
CHEMBL407411 | 157159 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1 | 10.1016/j.bmc.2007.11.049 | |||
46232621 | 204069 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 503 | 10 | 0 | 5 | 4.6 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
CHEMBL605787 | 204069 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 503 | 10 | 0 | 5 | 4.6 | COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1 | 10.1016/j.bmc.2009.12.067 | |||
3066250 | 70310 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | |||
CHEMBL194305 | 70310 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | |||
11005810 | 10469 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL116463 | 10469 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
71061887 | 93171 | None | 0 | Human | Binding | pKd | = | 8.9 | 8.9 | 66 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 | 10.1016/j.bmc.2014.01.016 | |||
CHEMBL2442996 | 93171 | None | 0 | Human | Binding | pKd | = | 8.9 | 8.9 | 66 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 | 10.1016/j.bmc.2014.01.016 | |||
11785183 | 84747 | None | 0 | Human | Binding | pKd | = | 7.8 | 7.8 | -1 | 4 | ChEMBL | 419 | 8 | 1 | 3 | 4.9 | Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL222755 | 84747 | None | 0 | Human | Binding | pKd | = | 7.8 | 7.8 | -1 | 4 | ChEMBL | 419 | 8 | 1 | 3 | 4.9 | Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
11224758 | 2353 | None | 4 | Human | Binding | pKd | = | 7.7 | 7.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
8435 | 2353 | None | 4 | Human | Binding | pKd | = | 7.7 | 7.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
CHEMBL225284 | 2353 | None | 4 | Human | Binding | pKd | = | 7.7 | 7.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
11282296 | 143402 | None | 0 | Human | Binding | pKd | = | 7.6 | 7.6 | -6 | 4 | ChEMBL | 447 | 9 | 1 | 4 | 4.8 | CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL389718 | 143402 | None | 0 | Human | Binding | pKd | = | 7.6 | 7.6 | -6 | 4 | ChEMBL | 447 | 9 | 1 | 4 | 4.8 | CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
5 | 139 | None | 45 | Human | Binding | pKd | = | 8.4 | 8.4 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.08.023 | |||
5202 | 139 | None | 45 | Human | Binding | pKd | = | 8.4 | 8.4 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKd | = | 8.4 | 8.4 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.08.023 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKd | = | 8.4 | 8.4 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.08.023 | |||
1809 | 134 | None | 25 | Human | Binding | pKd | = | 7.5 | 7.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
4 | 134 | None | 25 | Human | Binding | pKd | = | 7.5 | 7.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKd | = | 7.5 | 7.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
11191128 | 85244 | None | 0 | Human | Binding | pKd | = | 7.2 | 7.2 | -5 | 4 | ChEMBL | 421 | 8 | 2 | 4 | 4.3 | O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 | 10.1021/jm049702f | |||
CHEMBL225512 | 85244 | None | 0 | Human | Binding | pKd | = | 7.2 | 7.2 | -5 | 4 | ChEMBL | 421 | 8 | 2 | 4 | 4.3 | O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 | 10.1021/jm049702f | |||
11432177 | 85156 | None | 0 | Human | Binding | pKd | = | 8.0 | 8.0 | -1 | 4 | ChEMBL | 435 | 9 | 1 | 4 | 4.6 | COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
CHEMBL224820 | 85156 | None | 0 | Human | Binding | pKd | = | 8.0 | 8.0 | -1 | 4 | ChEMBL | 435 | 9 | 1 | 4 | 4.6 | COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm049702f | |||
3233 | 3512 | None | 28 | Human | Binding | pKd | = | 8.0 | 8.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2011.05.010 | |||
3247 | 3512 | None | 28 | Human | Binding | pKd | = | 8.0 | 8.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2011.05.010 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKd | = | 8.0 | 8.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2011.05.010 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKd | = | 8.0 | 8.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2011.05.010 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKd | = | 8.0 | 8.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2011.05.010 | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 10.5 | 10.5 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm9911433 | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 10.5 | 10.5 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm9911433 | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 10.5 | 10.5 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm9911433 | |||
56944082 | 112141 | None | 0 | Human | Binding | pKi | = | 10 | 10.0 | 169 | 4 | ChEMBL | 466 | 8 | 1 | 6 | 3.5 | O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm401895u | |||
CHEMBL3289972 | 112141 | None | 0 | Human | Binding | pKi | = | 10 | 10.0 | 169 | 4 | ChEMBL | 466 | 8 | 1 | 6 | 3.5 | O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm401895u | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 10.0 | 10.0 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 10.0 | 10.0 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 10.0 | 10.0 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 10.0 | 10.0 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2013.01.044 | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 9.9 | 9.9 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm030826m | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 9.9 | 9.9 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm030826m | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 9.9 | 9.9 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm030826m | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 9.9 | 9.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 9.9 | 9.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 9.9 | 9.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 9.9 | 9.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm2006782 | |||
23643664 | 2350 | None | 5 | Rat | Binding | pKi | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | 481 | 9 | 1 | 3 | 6.2 | O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm070487n | |||
8434 | 2350 | None | 5 | Rat | Binding | pKi | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | 481 | 9 | 1 | 3 | 6.2 | O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm070487n | |||
CHEMBL243954 | 2350 | None | 5 | Rat | Binding | pKi | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | 481 | 9 | 1 | 3 | 6.2 | O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm070487n | |||
42631003 | 202074 | None | 10 | Human | Binding | pKi | = | 9.8 | 9.8 | 2 | 8 | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.ejmech.2022.114464 | |||
CHEMBL592752 | 202074 | None | 10 | Human | Binding | pKi | = | 9.8 | 9.8 | 2 | 8 | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.ejmech.2022.114464 | |||
42631003 | 202074 | None | 10 | Human | Binding | pKi | = | 9.8 | 9.8 | 2 | 8 | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL592752 | 202074 | None | 10 | Human | Binding | pKi | = | 9.8 | 9.8 | 2 | 8 | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1021/acs.jmedchem.7b01898 | |||
168271260 | 190625 | None | 0 | Human | Binding | pKi | = | 9.8 | 9.8 | - | 1 | ChEMBL | 432 | 7 | 0 | 5 | 3.0 | O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5179460 | 190625 | None | 0 | Human | Binding | pKi | = | 9.8 | 9.8 | - | 1 | ChEMBL | 432 | 7 | 0 | 5 | 3.0 | O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01422 | |||
10450593 | 124332 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 75 | 3 | ChEMBL | 351 | 8 | 2 | 4 | 4.9 | C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 | 10.1016/j.bmcl.2010.03.012 | |||
CHEMBL363452 | 124332 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 75 | 3 | ChEMBL | 351 | 8 | 2 | 4 | 4.9 | C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 | 10.1016/j.bmcl.2010.03.012 | |||
10450593 | 124332 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 75 | 3 | ChEMBL | 351 | 8 | 2 | 4 | 4.9 | C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL363452 | 124332 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 75 | 3 | ChEMBL | 351 | 8 | 2 | 4 | 4.9 | C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
66801551 | 112186 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 3 | 4 | ChEMBL | 519 | 8 | 1 | 6 | 5.6 | Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 | 10.1021/jm401895u | |||
CHEMBL3290016 | 112186 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 3 | 4 | ChEMBL | 519 | 8 | 1 | 6 | 5.6 | Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 | 10.1021/jm401895u | |||
46224879 | 204004 | None | 3 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 7 | ChEMBL | 302 | 2 | 0 | 2 | 4.6 | Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | |||
CHEMBL605405 | 204004 | None | 3 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 7 | ChEMBL | 302 | 2 | 0 | 2 | 4.6 | Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | |||
168287666 | 191769 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 465 | 7 | 0 | 4 | 4.2 | O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5196234 | 191769 | None | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 465 | 7 | 0 | 4 | 4.2 | O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
11224758 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.03.005 | |||
8435 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL225284 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.03.005 | |||
11224758 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.12.041 | |||
8435 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL225284 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.12.041 | |||
11224758 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.08.023 | |||
8435 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL225284 | 2353 | None | 4 | Human | Binding | pKi | = | 9.7 | 9.7 | -4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1016/j.ejmech.2014.08.023 | |||
11224758 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/acs.jmedchem.5b00982 | |||
8435 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/acs.jmedchem.5b00982 | |||
CHEMBL225284 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/acs.jmedchem.5b00982 | |||
11224758 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/acs.jmedchem.7b01898 | |||
8435 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL225284 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/acs.jmedchem.7b01898 | |||
11224758 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
8435 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
CHEMBL225284 | 2353 | None | 4 | Rat | Binding | pKi | = | 9.7 | 9.7 | 4 | 6 | ChEMBL | 451 | 9 | 1 | 4 | 5.3 | CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2 | 10.1021/jm049702f | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 9.7 | 9.7 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 9.7 | 9.7 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 9.7 | 9.7 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 9.7 | 9.7 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm8007618 | |||
10402615 | 204974 | None | 0 | Rat | Binding | pKi | = | 9.6 | 9.6 | 20 | 3 | ChEMBL | 301 | 2 | 0 | 1 | 4.9 | CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 | 10.1021/jm030826m | |||
CHEMBL611472 | 204974 | None | 0 | Rat | Binding | pKi | = | 9.6 | 9.6 | 20 | 3 | ChEMBL | 301 | 2 | 0 | 1 | 4.9 | CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 | 10.1021/jm030826m | |||
42631003 | 202074 | None | 10 | Human | Binding | pKi | = | 9.6 | 9.6 | 2 | 8 | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | |||
CHEMBL592752 | 202074 | None | 10 | Human | Binding | pKi | = | 9.6 | 9.6 | 2 | 8 | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | |||
145989143 | 167282 | None | 0 | Human | Binding | pKi | = | 9.6 | 9.6 | 2 | 2 | ChEMBL | 399 | 5 | 1 | 2 | 5.3 | Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 | 10.1016/j.ejmech.2017.12.063 | |||
CHEMBL4291322 | 167282 | None | 0 | Human | Binding | pKi | = | 9.6 | 9.6 | 2 | 2 | ChEMBL | 399 | 5 | 1 | 2 | 5.3 | Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 | 10.1016/j.ejmech.2017.12.063 | |||
44393091 | 65378 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 317 | 7 | 2 | 3 | 4.9 | C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL182923 | 65378 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 317 | 7 | 2 | 3 | 4.9 | C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
44393169 | 65617 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 352 | 8 | 2 | 5 | 4.3 | C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL183277 | 65617 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 352 | 8 | 2 | 5 | 4.3 | C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
71454999 | 81453 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 169 | 4 | ChEMBL | 420 | 8 | 1 | 4 | 3.8 | CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159465 | 81453 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 169 | 4 | ChEMBL | 420 | 8 | 1 | 4 | 3.8 | CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2012.07.043 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.5 | 9.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm3003679 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.5 | 9.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm3003679 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.5 | 9.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm3003679 | |||
46233450 | 202699 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 357 | 6 | 0 | 1 | 6.5 | CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 | 10.1016/j.bmc.2010.01.035 | |||
CHEMBL596959 | 202699 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 357 | 6 | 0 | 1 | 6.5 | CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1 | 10.1016/j.bmc.2010.01.035 | |||
10413595 | 161935 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | -1 | 11 | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
CHEMBL414628 | 161935 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | -1 | 11 | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
168283786 | 190979 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 465 | 7 | 0 | 4 | 4.2 | O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5184712 | 190979 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 465 | 7 | 0 | 4 | 4.2 | O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.1c01093 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.07.029 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2016.01.043 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2014.07.026 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2014.07.026 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2014.07.026 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2014.07.026 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2014.07.026 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.8b00642 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.5 | 9.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2020.112395 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.5 | 9.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2020.112395 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.5 | 9.5 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2020.112395 | |||
11524413 | 96428 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
CHEMBL261719 | 96428 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
11589069 | 96300 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 10 | 8 | ChEMBL | 383 | 6 | 1 | 3 | 4.4 | O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm070279v | |||
CHEMBL260994 | 96300 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 10 | 8 | ChEMBL | 383 | 6 | 1 | 3 | 4.4 | O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm070279v | |||
11524413 | 96428 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL261719 | 96428 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
11524413 | 96428 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL261719 | 96428 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
44126269 | 203941 | None | 4 | Human | Binding | pKi | = | 9.4 | 9.4 | 2 | 6 | ChEMBL | 318 | 3 | 0 | 2 | 4.5 | Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | |||
CHEMBL605081 | 203941 | None | 4 | Human | Binding | pKi | = | 9.4 | 9.4 | 2 | 6 | ChEMBL | 318 | 3 | 0 | 2 | 4.5 | Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0341204 | |||
44393073 | 64484 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 333 | 8 | 2 | 4 | 4.7 | C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL181356 | 64484 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 333 | 8 | 2 | 4 | 4.7 | C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
44393092 | 64601 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 335 | 7 | 2 | 3 | 5.0 | C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL181605 | 64601 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 335 | 7 | 2 | 3 | 5.0 | C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
44393193 | 65662 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 32 | 2 | ChEMBL | 351 | 8 | 2 | 4 | 4.9 | C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL183423 | 65662 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 32 | 2 | ChEMBL | 351 | 8 | 2 | 4 | 4.9 | C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
44393192 | 66274 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 333 | 8 | 2 | 4 | 4.7 | C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL184607 | 66274 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 333 | 8 | 2 | 4 | 4.7 | C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
2389 | 3331 | None | 72 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2018.01.002 | |||
5073 | 3331 | None | 72 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2018.01.002 | |||
5073.0 | 3331 | None | 72 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2018.01.002 | |||
96 | 3331 | None | 72 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2018.01.002 | |||
DB00734 | 3331 | None | 72 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2018.01.002 | |||
145985050 | 165785 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 5 | ChEMBL | 508 | 6 | 0 | 6 | 4.9 | O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4245263 | 165785 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 5 | ChEMBL | 508 | 6 | 0 | 6 | 4.9 | O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2013.09.018 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2013.09.018 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.4 | 9.4 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.ejmech.2013.09.018 | |||
24854273 | 158464 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 112 | 2 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
CHEMBL408976 | 158464 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 112 | 2 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
56944763 | 112174 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 4 | 4 | ChEMBL | 453 | 6 | 1 | 5 | 4.3 | O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3290004 | 112174 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 4 | 4 | ChEMBL | 453 | 6 | 1 | 5 | 4.3 | O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
44266163 | 97108 | None | 1 | Human | Binding | pKi | = | 9.4 | 9.4 | 4 | 2 | ChEMBL | 387 | 4 | 1 | 2 | 4.4 | O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL267062 | 97108 | None | 1 | Human | Binding | pKi | = | 9.4 | 9.4 | 4 | 2 | ChEMBL | 387 | 4 | 1 | 2 | 4.4 | O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
24854273 | 158464 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 112 | 2 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL408976 | 158464 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 112 | 2 | ChEMBL | 411 | 7 | 1 | 3 | 4.9 | CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
24854187 | 96280 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 395 | 7 | 1 | 3 | 4.4 | CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
CHEMBL260872 | 96280 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 395 | 7 | 1 | 3 | 4.4 | CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
24854187 | 96280 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 395 | 7 | 1 | 3 | 4.4 | CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL260872 | 96280 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 395 | 7 | 1 | 3 | 4.4 | CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
132578545 | 154648 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 33 | 9 | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL3898250 | 154648 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 33 | 9 | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL3991133 | 154648 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 33 | 9 | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
25192947 | 164761 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 273 | 4 | 1 | 4 | 2.5 | Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL4216782 | 164761 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 273 | 4 | 1 | 4 | 2.5 | Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 | 10.1016/j.ejmech.2019.111705 | |||
25192947 | 164761 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 273 | 4 | 1 | 4 | 2.5 | Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL4216782 | 164761 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 273 | 4 | 1 | 4 | 2.5 | Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1 | 10.1021/acs.jmedchem.7b01898 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.3 | 9.3 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0104264 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.3 | 9.3 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0104264 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.3 | 9.3 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm0104264 | |||
11653869 | 96346 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 134 | 2 | ChEMBL | 383 | 6 | 1 | 3 | 4.4 | O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm200547z | |||
CHEMBL261209 | 96346 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 134 | 2 | ChEMBL | 383 | 6 | 1 | 3 | 4.4 | O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm200547z | |||
11653869 | 96346 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 134 | 2 | ChEMBL | 383 | 6 | 1 | 3 | 4.4 | O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm070279v | |||
CHEMBL261209 | 96346 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 134 | 2 | ChEMBL | 383 | 6 | 1 | 3 | 4.4 | O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm070279v | |||
16362 | 3125 | None | 49 | Rat | Binding | pKi | = | 9.3 | 9.3 | -5 | 29 | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1021/jm030030n | |||
16362.0 | 3125 | None | 49 | Rat | Binding | pKi | = | 9.3 | 9.3 | -5 | 29 | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1021/jm030030n | |||
2172 | 3125 | None | 49 | Rat | Binding | pKi | = | 9.3 | 9.3 | -5 | 29 | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1021/jm030030n | |||
90 | 3125 | None | 49 | Rat | Binding | pKi | = | 9.3 | 9.3 | -5 | 29 | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1021/jm030030n | |||
CHEMBL1423 | 3125 | None | 49 | Rat | Binding | pKi | = | 9.3 | 9.3 | -5 | 29 | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1021/jm030030n | |||
DB01100 | 3125 | None | 49 | Rat | Binding | pKi | = | 9.3 | 9.3 | -5 | 29 | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1021/jm030030n | |||
213046 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2019.111736 | |||
213046.0 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2019.111736 | |||
4168 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2019.111736 | |||
7461 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2019.111736 | |||
CHEMBL1237021 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2019.111736 | |||
DB08815 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.ejmech.2019.111736 | |||
213046 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.bmc.2020.115459 | |||
213046.0 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.bmc.2020.115459 | |||
4168 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.bmc.2020.115459 | |||
7461 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.bmc.2020.115459 | |||
CHEMBL1237021 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.bmc.2020.115459 | |||
DB08815 | 2385 | None | 44 | Human | Binding | pKi | = | 9.3 | 9.3 | 2 | 8 | ChEMBL | 492 | 5 | 0 | 6 | 4.3 | O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/j.bmc.2020.115459 | |||
132578545 | 154648 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 33 | 9 | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL3898250 | 154648 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 33 | 9 | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL3991133 | 154648 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 33 | 9 | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
66801167 | 112172 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 4 | ChEMBL | 467 | 7 | 1 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 | 10.1021/jm401895u | |||
CHEMBL3290002 | 112172 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 4 | ChEMBL | 467 | 7 | 1 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 | 10.1021/jm401895u | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm800615e | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm800615e | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm800615e | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm070487n | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm070487n | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm070487n | |||
44340836 | 161828 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 60 | 2 | ChEMBL | 471 | 7 | 1 | 4 | 4.4 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL413707 | 161828 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 60 | 2 | ChEMBL | 471 | 7 | 1 | 4 | 4.4 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm020994z | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm020994z | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm020994z | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.bmc.2007.05.010 | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.bmc.2007.05.010 | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1016/j.bmc.2007.05.010 | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm049702f | |||
4106 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112149 | |||
5358812 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112149 | |||
89 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112149 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.ejmech.2020.112149 | |||
145983405 | 166533 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 32 | 2 | ChEMBL | 449 | 6 | 1 | 2 | 6.0 | Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
CHEMBL4277476 | 166533 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 32 | 2 | ChEMBL | 449 | 6 | 1 | 2 | 6.0 | Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
44266221 | 210825 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 12 | 2 | ChEMBL | 405 | 4 | 0 | 3 | 4.5 | O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL9951 | 210825 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 12 | 2 | ChEMBL | 405 | 4 | 0 | 3 | 4.5 | O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
4106 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.1c00497 | |||
5358812 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.1c00497 | |||
89 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.1c00497 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pKi | = | 9.3 | 9.3 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.1c00497 | |||
25107716 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.bmc.2014.01.016 | |||
8436 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.bmc.2014.01.016 | |||
CHEMBL522691 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.bmc.2014.01.016 | |||
25107716 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm3003679 | |||
8436 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm3003679 | |||
CHEMBL522691 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm3003679 | |||
25107716 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.ejmech.2014.03.005 | |||
8436 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL522691 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.ejmech.2014.03.005 | |||
25107716 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.ejmech.2012.07.043 | |||
8436 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL522691 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1016/j.ejmech.2012.07.043 | |||
25107716 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm800615e | |||
8436 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm800615e | |||
CHEMBL522691 | 2351 | None | 38 | Rat | Binding | pKi | = | 9.2 | 9.2 | 3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1021/jm800615e | |||
23642275 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.ejmech.2019.111705 | |||
8433 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL2164327 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.ejmech.2019.111705 | |||
9881600 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL161765 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.ejmech.2019.111705 | |||
44393180 | 66686 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 318 | 7 | 2 | 4 | 4.3 | C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL185384 | 66686 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 318 | 7 | 2 | 4 | 4.3 | C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
23642275 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.7b01898 | |||
8433 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL2164327 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.7b01898 | |||
9881600 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.ejmech.2019.111690 | |||
CHEMBL161765 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.ejmech.2019.111690 | |||
23642275 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.bmc.2013.02.038 | |||
8433 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.bmc.2013.02.038 | |||
CHEMBL2164327 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.bmc.2013.02.038 | |||
9881600 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.bmcl.2003.11.050 | |||
CHEMBL161765 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.bmcl.2003.11.050 | |||
66803474 | 156407 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 4 | ChEMBL | 429 | 6 | 2 | 3 | 4.2 | Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL4065568 | 156407 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 4 | ChEMBL | 429 | 6 | 2 | 3 | 4.2 | Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 | 10.1021/acs.jmedchem.7b00839 | |||
11681111 | 120648 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 309 | 3 | 2 | 2 | 2.4 | CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343666 | 120648 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 309 | 3 | 2 | 2 | 2.4 | CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545815 | 120648 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 309 | 3 | 2 | 2 | 2.4 | CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
4431 | 2729 | None | 18 | Human | Binding | pKi | = | 9.2 | 9.2 | -20 | 12 | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1016/j.ejmech.2014.08.023 | |||
73 | 2729 | None | 18 | Human | Binding | pKi | = | 9.2 | 9.2 | -20 | 12 | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL8618 | 2729 | None | 18 | Human | Binding | pKi | = | 9.2 | 9.2 | -20 | 12 | ChEMBL | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 10.1016/j.ejmech.2014.08.023 | |||
9881600 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.bmc.2010.01.035 | |||
CHEMBL161765 | 55213 | None | 7 | Human | Binding | pKi | = | 9.2 | 9.2 | 8 | 5 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1cccc(-c2ccccc2)n1 | 10.1016/j.bmc.2010.01.035 | |||
24854371 | 95928 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 445 | 7 | 1 | 3 | 5.6 | CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
CHEMBL259087 | 95928 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 445 | 7 | 1 | 3 | 5.6 | CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
23642275 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1039/C8MD00313K | |||
8433 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1039/C8MD00313K | |||
CHEMBL2164327 | 482 | None | 26 | Human | Binding | pKi | = | 9.2 | 9.2 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1039/C8MD00313K | |||
56933434 | 112160 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 6 | 4 | ChEMBL | 431 | 7 | 1 | 5 | 3.8 | Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289991 | 112160 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 6 | 4 | ChEMBL | 431 | 7 | 1 | 5 | 3.8 | Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1021/jm401895u | |||
25107716 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1039/C8MD00313K | |||
8436 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1039/C8MD00313K | |||
CHEMBL522691 | 2351 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | -3 | 7 | ChEMBL | 466 | 10 | 1 | 4 | 5.2 | N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1 | 10.1039/C8MD00313K | |||
24853955 | 156284 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL406414 | 156284 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
5 | 139 | None | 45 | Rat | Binding | pKi | = | 9.2 | 9.2 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030826m | |||
5202 | 139 | None | 45 | Rat | Binding | pKi | = | 9.2 | 9.2 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030826m | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pKi | = | 9.2 | 9.2 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030826m | |||
DB08839 | 139 | None | 45 | Rat | Binding | pKi | = | 9.2 | 9.2 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030826m | |||
44437334 | 150586 | None | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 694 | 18 | 0 | 9 | 5.9 | COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
CHEMBL395444 | 150586 | None | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 694 | 18 | 0 | 9 | 5.9 | COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
24854371 | 95928 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 445 | 7 | 1 | 3 | 5.6 | CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL259087 | 95928 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 445 | 7 | 1 | 3 | 5.6 | CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
24854037 | 95927 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 425 | 7 | 1 | 3 | 5.2 | CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL259086 | 95927 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 425 | 7 | 1 | 3 | 5.2 | CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
24854041 | 96032 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1021/jm070279v | |||
CHEMBL259549 | 96032 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1021/jm070279v | |||
9934709 | 167927 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 476 | 6 | 2 | 3 | 5.1 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL430706 | 167927 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 476 | 6 | 2 | 3 | 5.1 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(02)00690-x | |||
9934709 | 167927 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 476 | 6 | 2 | 3 | 5.1 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2010.03.012 | |||
CHEMBL430706 | 167927 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 476 | 6 | 2 | 3 | 5.1 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2010.03.012 | |||
102364516 | 113607 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL3321794 | 113607 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1016/j.ejmech.2019.111705 | |||
10015688 | 51689 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 12 | 4 | ChEMBL | 264 | 5 | 0 | 3 | 3.8 | CN(C)CCSc1cccc(C2CCCCC2)n1 | 10.1016/j.bmcl.2003.11.050 | |||
CHEMBL158402 | 51689 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 12 | 4 | ChEMBL | 264 | 5 | 0 | 3 | 3.8 | CN(C)CCSc1cccc(C2CCCCC2)n1 | 10.1016/j.bmcl.2003.11.050 | |||
10015688 | 51689 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 12 | 4 | ChEMBL | 264 | 5 | 0 | 3 | 3.8 | CN(C)CCSc1cccc(C2CCCCC2)n1 | 10.1016/j.bmc.2010.01.035 | |||
CHEMBL158402 | 51689 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 12 | 4 | ChEMBL | 264 | 5 | 0 | 3 | 3.8 | CN(C)CCSc1cccc(C2CCCCC2)n1 | 10.1016/j.bmc.2010.01.035 | |||
102364516 | 113607 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1021/jm500880c | |||
CHEMBL3321794 | 113607 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 346 | 6 | 0 | 2 | 4.0 | O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1 | 10.1021/jm500880c | |||
66801263 | 112139 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 14 | 4 | ChEMBL | 482 | 8 | 1 | 6 | 4.0 | O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm401895u | |||
CHEMBL3289970 | 112139 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 14 | 4 | ChEMBL | 482 | 8 | 1 | 6 | 4.0 | O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm401895u | |||
66801210 | 112187 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | 535 | 8 | 1 | 6 | 6.1 | Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12 | 10.1021/jm401895u | |||
CHEMBL3290017 | 112187 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | 535 | 8 | 1 | 6 | 6.1 | Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12 | 10.1021/jm401895u | |||
44340854 | 10061 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 61 | 2 | ChEMBL | 493 | 6 | 2 | 6 | 4.1 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL115262 | 10061 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 61 | 2 | ChEMBL | 493 | 6 | 2 | 6 | 4.1 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1 | 10.1016/s0960-894x(02)00690-x | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2016.06.080 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2016.06.080 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2016.06.080 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2016.06.080 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2016.06.080 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.12.039 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.12.039 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.12.039 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.12.039 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.12.039 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2015.02.042 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2015.02.042 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2015.02.042 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2015.02.042 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2015.02.042 | |||
168297777 | 193013 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 398 | 8 | 0 | 4 | 3.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5184185 | 193013 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 398 | 8 | 0 | 4 | 3.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5222088 | 193013 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 398 | 8 | 0 | 4 | 3.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
145974165 | 164683 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 8 | 2 | ChEMBL | 410 | 5 | 0 | 2 | 6.0 | Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl | 10.1016/j.bmcl.2017.11.007 | |||
CHEMBL4215605 | 164683 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 8 | 2 | ChEMBL | 410 | 5 | 0 | 2 | 6.0 | Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl | 10.1016/j.bmcl.2017.11.007 | |||
118717217 | 120640 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 2 | 2 | ChEMBL | 325 | 4 | 2 | 3 | 1.6 | COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343667 | 120640 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 2 | 2 | ChEMBL | 325 | 4 | 2 | 3 | 1.6 | COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545762 | 120640 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 2 | 2 | ChEMBL | 325 | 4 | 2 | 3 | 1.6 | COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
24829343 | 159113 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 24 | 9 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL409662 | 159113 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 24 | 9 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1016/j.ejmech.2019.111705 | |||
24829343 | 159113 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 24 | 9 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1021/jm200547z | |||
CHEMBL409662 | 159113 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 24 | 9 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1021/jm200547z | |||
24829343 | 159113 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 24 | 9 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1021/jm070279v | |||
CHEMBL409662 | 159113 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 24 | 9 | ChEMBL | 429 | 7 | 1 | 3 | 5.1 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21 | 10.1021/jm070279v | |||
145991084 | 166966 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 7 | 2 | ChEMBL | 417 | 5 | 1 | 2 | 5.5 | Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
CHEMBL4285796 | 166966 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 7 | 2 | ChEMBL | 417 | 5 | 1 | 2 | 5.5 | Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
44340835 | 10411 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 117 | 2 | ChEMBL | 499 | 7 | 1 | 4 | 5.0 | O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL116292 | 10411 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 117 | 2 | ChEMBL | 499 | 7 | 1 | 4 | 5.0 | O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
155568606 | 176212 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL4591601 | 176212 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 2 | ChEMBL | 532 | 9 | 1 | 6 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC | 10.1016/j.bmc.2019.07.046 | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.12.045 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.12.045 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.12.045 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.12.045 | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm401895u | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm401895u | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm401895u | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 9.1 | 9.1 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm401895u | |||
66801158 | 112147 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 4 | ChEMBL | 464 | 8 | 1 | 6 | 3.9 | O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3289978 | 112147 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 4 | ChEMBL | 464 | 8 | 1 | 6 | 3.9 | O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
56944665 | 112173 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 4 | ChEMBL | 481 | 8 | 1 | 5 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 | 10.1021/jm401895u | |||
CHEMBL3290003 | 112173 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 4 | ChEMBL | 481 | 8 | 1 | 5 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 | 10.1021/jm401895u | |||
56944668 | 112175 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 4 | ChEMBL | 467 | 7 | 1 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3290005 | 112175 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 4 | ChEMBL | 467 | 7 | 1 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
25107518 | 187390 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | 20 | 4 | ChEMBL | 441 | 10 | 1 | 3 | 5.4 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 | 10.1021/jm800615e | |||
CHEMBL492871 | 187390 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | 20 | 4 | ChEMBL | 441 | 10 | 1 | 3 | 5.4 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1 | 10.1021/jm800615e | |||
9971032 | 204662 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 282 | 2 | 1 | 1 | 4.0 | Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C | 10.1021/jm030826m | |||
CHEMBL609675 | 204662 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 282 | 2 | 1 | 1 | 4.0 | Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C | 10.1021/jm030826m | |||
44340850 | 9904 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 22 | 2 | ChEMBL | 483 | 7 | 1 | 4 | 4.4 | O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL114345 | 9904 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 22 | 2 | ChEMBL | 483 | 7 | 1 | 4 | 4.4 | O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
155516399 | 170174 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 47 | 2 | ChEMBL | 368 | 6 | 1 | 5 | 3.1 | O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12 | 10.1016/j.ejmech.2019.111690 | |||
CHEMBL4443201 | 170174 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 47 | 2 | ChEMBL | 368 | 6 | 1 | 5 | 3.1 | O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12 | 10.1016/j.ejmech.2019.111690 | |||
10069973 | 52415 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | 4 | 5 | ChEMBL | 407 | 9 | 0 | 6 | 4.4 | COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 | 10.1021/jm020994z | |||
CHEMBL159022 | 52415 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | 4 | 5 | ChEMBL | 407 | 9 | 0 | 6 | 4.4 | COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 | 10.1021/jm020994z | |||
155552188 | 174168 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 7 | 2 | ChEMBL | 421 | 6 | 2 | 3 | 4.6 | Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1 | 10.1016/j.bmcl.2019.126703 | |||
CHEMBL4544153 | 174168 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 7 | 2 | ChEMBL | 421 | 6 | 2 | 3 | 4.6 | Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1 | 10.1016/j.bmcl.2019.126703 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.1 | 9.1 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm030030n | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.1 | 9.1 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm030030n | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.1 | 9.1 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm030030n | |||
4106 | 2502 | None | 21 | Human | Binding | pKi | = | 9.1 | 9.1 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
5358812 | 2502 | None | 21 | Human | Binding | pKi | = | 9.1 | 9.1 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
89 | 2502 | None | 21 | Human | Binding | pKi | = | 9.1 | 9.1 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pKi | = | 9.1 | 9.1 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/jm401895u | |||
66801234 | 112164 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 4 | ChEMBL | 469 | 7 | 1 | 5 | 4.3 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm401895u | |||
CHEMBL3289995 | 112164 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 4 | ChEMBL | 469 | 7 | 1 | 5 | 4.3 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm401895u | |||
66801271 | 112168 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | ChEMBL | 423 | 7 | 1 | 6 | 3.6 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 | 10.1021/jm401895u | |||
CHEMBL3289999 | 112168 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | ChEMBL | 423 | 7 | 1 | 6 | 3.6 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1 | 10.1021/jm401895u | |||
66801139 | 112179 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 4 | ChEMBL | 473 | 7 | 1 | 6 | 4.7 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 | 10.1021/jm401895u | |||
CHEMBL3290009 | 112179 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 4 | ChEMBL | 473 | 7 | 1 | 6 | 4.7 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12 | 10.1021/jm401895u | |||
23643870 | 92917 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | 35 | 3 | ChEMBL | 448 | 9 | 1 | 4 | 4.6 | CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL243955 | 92917 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | 35 | 3 | ChEMBL | 448 | 9 | 1 | 4 | 4.6 | CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
44437328 | 91016 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 678 | 17 | 0 | 8 | 6.7 | COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
CHEMBL239656 | 91016 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 678 | 17 | 0 | 8 | 6.7 | COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 9.0 | 9.0 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/acs.jmedchem.7b01898 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 9.0 | 9.0 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 9.0 | 9.0 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/acs.jmedchem.7b01898 | |||
107 | 141 | None | 65 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 30 | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm030826m | |||
1833 | 141 | None | 65 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 30 | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm030826m | |||
CHEMBL8165 | 141 | None | 65 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 30 | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1021/jm030826m | |||
25107520 | 187699 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | 70 | 3 | ChEMBL | 442 | 10 | 1 | 4 | 4.7 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 | 10.1021/jm800615e | |||
CHEMBL494709 | 187699 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | 70 | 3 | ChEMBL | 442 | 10 | 1 | 4 | 4.7 | O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1 | 10.1021/jm800615e | |||
141745651 | 175450 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 2 | ChEMBL | 380 | 4 | 1 | 4 | 4.3 | Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1 | 10.1016/j.bmcl.2019.126703 | |||
CHEMBL4574299 | 175450 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 2 | ChEMBL | 380 | 4 | 1 | 4 | 4.3 | Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1 | 10.1016/j.bmcl.2019.126703 | |||
118713589 | 114438 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 10 | 2 | ChEMBL | 381 | 6 | 0 | 5 | 4.0 | Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL3331258 | 114438 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 10 | 2 | ChEMBL | 381 | 6 | 0 | 5 | 4.0 | Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
44393134 | 64870 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 39 | 2 | ChEMBL | 352 | 8 | 2 | 5 | 4.3 | CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
CHEMBL182071 | 64870 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 39 | 2 | ChEMBL | 352 | 8 | 2 | 5 | 4.3 | CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.007 | |||
4184551 | 192770 | None | 5 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 | 10.1016/j.bmcl.2021.128275 | |||
CHEMBL5218527 | 192770 | None | 5 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 | 10.1016/j.bmcl.2021.128275 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2010.11.078 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2010.11.078 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2010.11.078 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2010.11.078 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2010.11.078 | |||
7059581 | 167141 | None | 1 | Rat | Binding | pKi | = | 9 | 9.0 | -1 | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL428892 | 167141 | None | 1 | Rat | Binding | pKi | = | 9 | 9.0 | -1 | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1016/s0960-894x(00)00166-9 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00438-9 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00438-9 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00438-9 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00438-9 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 9 | 9.0 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00438-9 | |||
11725453 | 99134 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 6 | ChEMBL | 350 | 1 | 0 | 2 | 5.3 | Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 | 10.1016/s0960-894x(02)00438-9 | |||
CHEMBL28056 | 99134 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 6 | ChEMBL | 350 | 1 | 0 | 2 | 5.3 | Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 | 10.1016/s0960-894x(02)00438-9 | |||
3233 | 3512 | None | 28 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm049743b | |||
3247 | 3512 | None | 28 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm049743b | |||
6604889 | 3512 | None | 28 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm049743b | |||
CHEMBL282199 | 3512 | None | 28 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm049743b | |||
DB13988 | 3512 | None | 28 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm049743b | |||
7059581 | 167141 | None | 1 | Rat | Binding | pKi | = | 9 | 9.0 | -1 | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm049743b | |||
CHEMBL428892 | 167141 | None | 1 | Rat | Binding | pKi | = | 9 | 9.0 | -1 | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm049743b | |||
127025243 | 137830 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 60 | 5 | ChEMBL | 446 | 8 | 1 | 4 | 4.3 | CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1 | 10.1016/j.ejmech.2015.11.040 | |||
CHEMBL3759205 | 137830 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 60 | 5 | ChEMBL | 446 | 8 | 1 | 4 | 4.3 | CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1 | 10.1016/j.ejmech.2015.11.040 | |||
145985692 | 165539 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -3 | 5 | ChEMBL | 507 | 6 | 0 | 7 | 4.2 | O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4239091 | 165539 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -3 | 5 | ChEMBL | 507 | 6 | 0 | 7 | 4.2 | O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
118626161 | 165694 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 5 | ChEMBL | 507 | 6 | 0 | 7 | 4.2 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4242858 | 165694 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 5 | ChEMBL | 507 | 6 | 0 | 7 | 4.2 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
118626129 | 165737 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 3 | 5 | ChEMBL | 506 | 6 | 0 | 6 | 4.8 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4243848 | 165737 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 3 | 5 | ChEMBL | 506 | 6 | 0 | 6 | 4.8 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
156021386 | 178195 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 7 | 2 | ChEMBL | 285 | 2 | 0 | 1 | 4.4 | CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1 | 10.1016/j.bmc.2019.115262 | |||
CHEMBL4647808 | 178195 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 7 | 2 | ChEMBL | 285 | 2 | 0 | 1 | 4.4 | CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1 | 10.1016/j.bmc.2019.115262 | |||
4106 | 2502 | None | 21 | Human | Binding | pKi | = | 9 | 9.0 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.7b00839 | |||
5358812 | 2502 | None | 21 | Human | Binding | pKi | = | 9 | 9.0 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.7b00839 | |||
89 | 2502 | None | 21 | Human | Binding | pKi | = | 9 | 9.0 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pKi | = | 9 | 9.0 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1021/acs.jmedchem.7b00839 | |||
66803595 | 159822 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 4 | ChEMBL | 431 | 6 | 3 | 4 | 3.6 | O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL4104622 | 159822 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 4 | ChEMBL | 431 | 6 | 3 | 4 | 3.6 | O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 | 10.1021/acs.jmedchem.7b00839 | |||
155531753 | 171749 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 2 | ChEMBL | 548 | 11 | 1 | 7 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 | 10.1016/j.bmc.2019.07.046 | |||
CHEMBL4465959 | 171749 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | -1 | 2 | ChEMBL | 548 | 11 | 1 | 7 | 4.5 | COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1 | 10.1016/j.bmc.2019.07.046 | |||
19605739 | 170115 | None | 10 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 204 | 3 | 3 | 2 | 1.4 | NCCc1c[nH]c2ccc(C(=O)O)cc12 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL4442472 | 170115 | None | 10 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 204 | 3 | 3 | 2 | 1.4 | NCCc1c[nH]c2ccc(C(=O)O)cc12 | 10.1016/j.ejmech.2019.111705 | |||
2389 | 3331 | None | 72 | Human | Binding | pKi | = | 9 | 9.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | |||
5073 | 3331 | None | 72 | Human | Binding | pKi | = | 9 | 9.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | |||
5073.0 | 3331 | None | 72 | Human | Binding | pKi | = | 9 | 9.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | |||
96 | 3331 | None | 72 | Human | Binding | pKi | = | 9 | 9.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pKi | = | 9 | 9.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | |||
DB00734 | 3331 | None | 72 | Human | Binding | pKi | = | 9 | 9.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | |||
16006607 | 95725 | None | 2 | Human | Binding | pKi | = | 9 | 9.0 | 10 | 5 | ChEMBL | 219 | 2 | 2 | 4 | 2.1 | CC(C)Oc1cccc2c1N=C(N)NC2C | 10.1016/j.bmcl.2007.10.080 | |||
CHEMBL258075 | 95725 | None | 2 | Human | Binding | pKi | = | 9 | 9.0 | 10 | 5 | ChEMBL | 219 | 2 | 2 | 4 | 2.1 | CC(C)Oc1cccc2c1N=C(N)NC2C | 10.1016/j.bmcl.2007.10.080 | |||
7059581 | 167141 | None | 1 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm030841r | |||
CHEMBL428892 | 167141 | None | 1 | Human | Binding | pKi | = | 9 | 9.0 | 1 | 2 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm030841r | |||
11661471 | 159622 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 408 | 7 | 1 | 2 | 5.9 | CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL410226 | 159622 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 408 | 7 | 1 | 2 | 5.9 | CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
10346043 | 47134 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -1 | 3 | ChEMBL | 503 | 5 | 2 | 5 | 3.4 | COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
CHEMBL154274 | 47134 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -1 | 3 | ChEMBL | 503 | 5 | 2 | 5 | 3.4 | COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
10379532 | 99329 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1016/j.bmcl.2010.03.012 | |||
CHEMBL281923 | 99329 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1016/j.bmcl.2010.03.012 | |||
10062885 | 99330 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm060959i | |||
CHEMBL281924 | 99330 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm060959i | |||
78108787 | 192076 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 363 | 6 | 1 | 3 | 4.0 | Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5201016 | 192076 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 363 | 6 | 1 | 3 | 4.0 | Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00633 | |||
10379532 | 99329 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm030030n | |||
CHEMBL281923 | 99329 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm030030n | |||
10062885 | 99330 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm030030n | |||
CHEMBL281924 | 99330 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm030030n | |||
10062885 | 99330 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL281924 | 99330 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1016/j.bmc.2020.115578 | |||
10379532 | 99329 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm9911433 | |||
CHEMBL281923 | 99329 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm9911433 | |||
10062885 | 99330 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm9911433 | |||
CHEMBL281924 | 99330 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | ChEMBL | 291 | 1 | 0 | 2 | 3.7 | CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1 | 10.1021/jm9911433 | |||
24854044 | 97352 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 445 | 7 | 1 | 3 | 5.6 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21 | 10.1021/jm200547z | |||
CHEMBL269083 | 97352 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 445 | 7 | 1 | 3 | 5.6 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21 | 10.1021/jm200547z | |||
56944664 | 112136 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 23 | 4 | ChEMBL | 428 | 8 | 1 | 6 | 3.0 | Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289968 | 112136 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 23 | 4 | ChEMBL | 428 | 8 | 1 | 6 | 3.0 | Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
56944764 | 112159 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 3 | 4 | ChEMBL | 417 | 6 | 1 | 5 | 3.4 | Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289990 | 112159 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 3 | 4 | ChEMBL | 417 | 6 | 1 | 5 | 3.4 | Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1021/jm401895u | |||
23643663 | 92897 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | 13 | 3 | ChEMBL | 447 | 9 | 1 | 3 | 5.7 | CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
CHEMBL243744 | 92897 | None | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | 13 | 3 | ChEMBL | 447 | 9 | 1 | 3 | 5.7 | CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1 | 10.1021/jm070487n | |||
145981875 | 166616 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 7 | 2 | ChEMBL | 431 | 6 | 1 | 2 | 5.9 | Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
CHEMBL4278933 | 166616 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 7 | 2 | ChEMBL | 431 | 6 | 1 | 2 | 5.9 | Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
145992877 | 166992 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 11 | 2 | ChEMBL | 413 | 6 | 1 | 2 | 5.7 | Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 | 10.1016/j.ejmech.2017.12.063 | |||
CHEMBL4286174 | 166992 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 11 | 2 | ChEMBL | 413 | 6 | 1 | 2 | 5.7 | Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1 | 10.1016/j.ejmech.2017.12.063 | |||
3044582 | 192522 | None | 1 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2 | 10.1016/j.ejmech.2022.114218 | |||
CHEMBL5208064 | 192522 | None | 1 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2 | 10.1016/j.ejmech.2022.114218 | |||
1809 | 134 | None | 25 | Human | Binding | pKi | = | 8.9 | 8.9 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.6019/CHEMBL5442175 | |||
4 | 134 | None | 25 | Human | Binding | pKi | = | 8.9 | 8.9 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.6019/CHEMBL5442175 | |||
CHEMBL18840 | 134 | None | 25 | Human | Binding | pKi | = | 8.9 | 8.9 | -7 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.6019/CHEMBL5442175 | |||
11524003 | 159621 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 392 | 7 | 1 | 2 | 5.4 | CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL410225 | 159621 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 392 | 7 | 1 | 2 | 5.4 | CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2009.06.038 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2009.06.038 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2009.06.038 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2009.06.038 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmcl.2009.06.038 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2011.09.044 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2011.09.044 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2011.09.044 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2011.09.044 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2011.09.044 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2012.07.043 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2012.07.043 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2012.07.043 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2012.07.043 | |||
118717211 | 120642 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 33 | 2 | ChEMBL | 295 | 2 | 3 | 2 | 1.7 | CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343663 | 120642 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 33 | 2 | ChEMBL | 295 | 2 | 3 | 2 | 1.7 | CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545801 | 120642 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 33 | 2 | ChEMBL | 295 | 2 | 3 | 2 | 1.7 | CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
11524003 | 159621 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 392 | 7 | 1 | 2 | 5.4 | CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
CHEMBL410225 | 159621 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 392 | 7 | 1 | 2 | 5.4 | CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
66801346 | 112162 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | 485 | 7 | 1 | 5 | 4.8 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm401895u | |||
CHEMBL3289993 | 112162 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | 485 | 7 | 1 | 5 | 4.8 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm401895u | |||
24854181 | 96485 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 425 | 8 | 1 | 3 | 5.3 | CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL262068 | 96485 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 425 | 8 | 1 | 3 | 5.3 | CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111705 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111705 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111705 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111705 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00690-x | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00690-x | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00690-x | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/s0960-894x(02)00690-x | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030841r | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030841r | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030841r | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030841r | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030841r | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2013.02.038 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2013.02.038 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2013.02.038 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2013.02.038 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2013.02.038 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.7b01898 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.7b01898 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.7b01898 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/acs.jmedchem.7b01898 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2014.08.023 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2014.08.023 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2014.08.023 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2014.08.023 | |||
3233 | 3512 | None | 28 | Rat | Binding | pKi | = | 8.9 | 8.9 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm0108505 | |||
3247 | 3512 | None | 28 | Rat | Binding | pKi | = | 8.9 | 8.9 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm0108505 | |||
6604889 | 3512 | None | 28 | Rat | Binding | pKi | = | 8.9 | 8.9 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm0108505 | |||
CHEMBL282199 | 3512 | None | 28 | Rat | Binding | pKi | = | 8.9 | 8.9 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm0108505 | |||
DB13988 | 3512 | None | 28 | Rat | Binding | pKi | = | 8.9 | 8.9 | -2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm0108505 | |||
24825775 | 1523 | None | 16 | Human | Binding | pKi | = | 8.9 | 8.9 | 346 | 2 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3929 | 1523 | None | 16 | Human | Binding | pKi | = | 8.9 | 8.9 | 346 | 2 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL4205349 | 1523 | None | 16 | Human | Binding | pKi | = | 8.9 | 8.9 | 346 | 2 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030030n | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030030n | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030030n | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030030n | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm030030n | |||
15803947 | 52370 | None | 1 | Human | Binding | pKi | = | 8.9 | 8.9 | 13 | 4 | ChEMBL | 161 | 3 | 0 | 2 | 2.1 | CN(C)CCSC(C)(C)C | 10.1016/j.bmcl.2003.11.050 | |||
CHEMBL158973 | 52370 | None | 1 | Human | Binding | pKi | = | 8.9 | 8.9 | 13 | 4 | ChEMBL | 161 | 3 | 0 | 2 | 2.1 | CN(C)CCSC(C)(C)C | 10.1016/j.bmcl.2003.11.050 | |||
24825775 | 1523 | None | 16 | Human | Binding | pKi | = | 8.9 | 8.9 | 346 | 2 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3929 | 1523 | None | 16 | Human | Binding | pKi | = | 8.9 | 8.9 | 346 | 2 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
CHEMBL4205349 | 1523 | None | 16 | Human | Binding | pKi | = | 8.9 | 8.9 | 346 | 2 | ChEMBL | 257 | 4 | 0 | 3 | 2.8 | CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C | 10.1021/acs.jmedchem.1c00110 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.bmc.2016.09.019 | |||
118717223 | 120646 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 7 | 2 | ChEMBL | 321 | 1 | 2 | 2 | 2.2 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343671 | 120646 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 7 | 2 | ChEMBL | 321 | 1 | 2 | 2 | 2.2 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545813 | 120646 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 7 | 2 | ChEMBL | 321 | 1 | 2 | 2 | 2.2 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
56944859 | 112171 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 453 | 6 | 1 | 5 | 4.3 | O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 | 10.1021/jm401895u | |||
CHEMBL3290001 | 112171 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 453 | 6 | 1 | 5 | 4.3 | O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12 | 10.1021/jm401895u | |||
56944384 | 112184 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 521 | 8 | 1 | 6 | 5.8 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 | 10.1021/jm401895u | |||
CHEMBL3290014 | 112184 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 521 | 8 | 1 | 6 | 5.8 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1 | 10.1021/jm401895u | |||
66801565 | 112190 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 7 | 3 | ChEMBL | 474 | 7 | 1 | 7 | 4.1 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 | 10.1021/jm401895u | |||
CHEMBL3290020 | 112190 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 7 | 3 | ChEMBL | 474 | 7 | 1 | 7 | 4.1 | O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12 | 10.1021/jm401895u | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.6019/CHEMBL5442175 | |||
2389 | 3331 | None | 72 | Rat | Binding | pKi | = | 8.9 | 8.9 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030030n | |||
5073 | 3331 | None | 72 | Rat | Binding | pKi | = | 8.9 | 8.9 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030030n | |||
5073.0 | 3331 | None | 72 | Rat | Binding | pKi | = | 8.9 | 8.9 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030030n | |||
96 | 3331 | None | 72 | Rat | Binding | pKi | = | 8.9 | 8.9 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030030n | |||
CHEMBL85 | 3331 | None | 72 | Rat | Binding | pKi | = | 8.9 | 8.9 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030030n | |||
DB00734 | 3331 | None | 72 | Rat | Binding | pKi | = | 8.9 | 8.9 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030030n | |||
60196080 | 81838 | None | 1 | Human | Binding | pKi | = | 8.9 | 8.9 | 12 | 2 | ChEMBL | 252 | 2 | 1 | 2 | 3.1 | Cc1ccccc1-c1cccc(N2CCNCC2)c1 | 10.1021/jm3003679 | |||
CHEMBL2164330 | 81838 | None | 1 | Human | Binding | pKi | = | 8.9 | 8.9 | 12 | 2 | ChEMBL | 252 | 2 | 1 | 2 | 3.1 | Cc1ccccc1-c1cccc(N2CCNCC2)c1 | 10.1021/jm3003679 | |||
2737389 | 187692 | None | 22 | Human | Binding | pKi | = | 8.9 | 8.9 | 53 | 5 | ChEMBL | 238 | 2 | 1 | 2 | 2.8 | c1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1021/jm3003679 | |||
CHEMBL494675 | 187692 | None | 22 | Human | Binding | pKi | = | 8.9 | 8.9 | 53 | 5 | ChEMBL | 238 | 2 | 1 | 2 | 2.8 | c1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1021/jm3003679 | |||
11637931 | 120647 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 2 | ChEMBL | 295 | 2 | 2 | 2 | 2.0 | COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343665 | 120647 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 2 | ChEMBL | 295 | 2 | 2 | 2 | 2.0 | COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545814 | 120647 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 2 | 2 | ChEMBL | 295 | 2 | 2 | 2 | 2.0 | COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21 | 10.1016/j.bmc.2014.09.005 | |||
5 | 139 | None | 45 | Human | Binding | pKi | = | 8.9 | 8.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.04.034 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | = | 8.9 | 8.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | = | 8.9 | 8.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.04.034 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | = | 8.9 | 8.9 | -3 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2014.04.034 | |||
56944666 | 112176 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 481 | 8 | 1 | 5 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3290006 | 112176 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 481 | 8 | 1 | 5 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
2737389 | 187692 | None | 22 | Human | Binding | pKi | = | 8.9 | 8.9 | 53 | 5 | ChEMBL | 238 | 2 | 1 | 2 | 2.8 | c1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1039/C8MD00313K | |||
CHEMBL494675 | 187692 | None | 22 | Human | Binding | pKi | = | 8.9 | 8.9 | 53 | 5 | ChEMBL | 238 | 2 | 1 | 2 | 2.8 | c1ccc(-c2ccccc2N2CCNCC2)cc1 | 10.1039/C8MD00313K | |||
162643494 | 181755 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 4 | ChEMBL | 437 | 7 | 1 | 5 | 3.6 | O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 | 10.1016/j.ejmech.2020.112149 | |||
CHEMBL4775997 | 181755 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 4 | ChEMBL | 437 | 7 | 1 | 5 | 3.6 | O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1 | 10.1016/j.ejmech.2020.112149 | |||
24854111 | 95812 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 425 | 8 | 1 | 3 | 5.3 | CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL258496 | 95812 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 425 | 8 | 1 | 3 | 5.3 | CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
66801229 | 112120 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | 452 | 6 | 1 | 6 | 3.6 | O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3289952 | 112120 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | 452 | 6 | 1 | 6 | 3.6 | O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
66800939 | 112121 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | 466 | 7 | 1 | 6 | 3.9 | O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3289953 | 112121 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | 466 | 7 | 1 | 6 | 3.9 | O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
56944667 | 112161 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | 445 | 8 | 1 | 5 | 4.2 | Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289992 | 112161 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | 445 | 8 | 1 | 5 | 4.2 | Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1021/jm401895u | |||
24854183 | 95955 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 413 | 7 | 1 | 3 | 4.6 | CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21 | 10.1021/jm070279v | |||
CHEMBL259216 | 95955 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 413 | 7 | 1 | 3 | 4.6 | CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21 | 10.1021/jm070279v | |||
CHEMBL5094234 | 218063 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 2 | 8 | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5096019 | 218063 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 2 | 8 | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
134155116 | 151057 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 12 | 7 | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL3958215 | 151057 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 12 | 7 | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL5091373 | 218057 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 9 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
CHEMBL5095981 | 218057 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 9 | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
134155116 | 151057 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 12 | 7 | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
CHEMBL3958215 | 151057 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 12 | 7 | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | |||
132525570 | 163740 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 6 | 5 | ChEMBL | 300 | 5 | 0 | 5 | 2.8 | CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1 | 10.1021/acs.jmedchem.7b01898 | |||
CHEMBL4204059 | 163740 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 6 | 5 | ChEMBL | 300 | 5 | 0 | 5 | 2.8 | CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1 | 10.1021/acs.jmedchem.7b01898 | |||
56944565 | 112112 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 4 | ChEMBL | 444 | 8 | 1 | 6 | 3.5 | Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289944 | 112112 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 4 | ChEMBL | 444 | 8 | 1 | 6 | 3.5 | Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
56944383 | 112182 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 12 | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | |||
CHEMBL3290012 | 112182 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 12 | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | |||
44437330 | 152278 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 706 | 19 | 0 | 8 | 7.5 | COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
CHEMBL396844 | 152278 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 706 | 19 | 0 | 8 | 7.5 | COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
44266268 | 210256 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 10 | 2 | ChEMBL | 394 | 5 | 0 | 3 | 3.8 | O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL9616 | 210256 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 10 | 2 | ChEMBL | 394 | 5 | 0 | 3 | 3.8 | O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
162652285 | 180381 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 2 | 4 | ChEMBL | 399 | 7 | 1 | 5 | 3.1 | Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1 | 10.1016/j.ejmech.2020.112149 | |||
CHEMBL4750664 | 180381 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 2 | 4 | ChEMBL | 399 | 7 | 1 | 5 | 3.1 | Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1 | 10.1016/j.ejmech.2020.112149 | |||
162654074 | 180685 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 4 | ChEMBL | 435 | 7 | 1 | 5 | 4.0 | O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 | 10.1016/j.ejmech.2020.112149 | |||
CHEMBL4754138 | 180685 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -3 | 4 | ChEMBL | 435 | 7 | 1 | 5 | 4.0 | O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12 | 10.1016/j.ejmech.2020.112149 | |||
11500509 | 120645 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 3 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343670 | 120645 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 3 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545812 | 120645 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 3 | ChEMBL | 307 | 1 | 2 | 2 | 2.1 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
66801107 | 112109 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | 430 | 7 | 1 | 6 | 3.1 | Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289709 | 112109 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 4 | ChEMBL | 430 | 7 | 1 | 6 | 3.1 | Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
4106 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2018.04.059 | |||
5358812 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2018.04.059 | |||
89 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2018.04.059 | |||
4106 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2023.117256 | |||
5358812 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2023.117256 | |||
89 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2023.117256 | |||
CHEMBL93240 | 2502 | None | 21 | Human | Binding | pKi | = | 8.8 | 8.8 | -4 | 33 | ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmc.2023.117256 | |||
118713592 | 114442 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 401 | 6 | 0 | 5 | 4.3 | O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL3331261 | 114442 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 401 | 6 | 0 | 5 | 4.3 | O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
11187960 | 66251 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | 6 | 2 | ChEMBL | 337 | 7 | 0 | 2 | 5.3 | CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1 | 10.1021/jm0498102 | |||
CHEMBL184535 | 66251 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | 6 | 2 | ChEMBL | 337 | 7 | 0 | 2 | 5.3 | CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1 | 10.1021/jm0498102 | |||
44437329 | 151689 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -8 | 2 | ChEMBL | 692 | 18 | 0 | 8 | 7.1 | COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
CHEMBL396349 | 151689 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -8 | 2 | ChEMBL | 692 | 18 | 0 | 8 | 7.1 | COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2007.05.010 | |||
1809 | 134 | None | 25 | Rat | Binding | pKi | = | 8.7 | 8.7 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm400766k | |||
4 | 134 | None | 25 | Rat | Binding | pKi | = | 8.7 | 8.7 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm400766k | |||
CHEMBL18840 | 134 | None | 25 | Rat | Binding | pKi | = | 8.7 | 8.7 | -2 | 37 | ChEMBL | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 10.1021/jm400766k | |||
118717220 | 120644 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 305 | 1 | 2 | 1 | 2.9 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3343669 | 120644 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 305 | 1 | 2 | 1 | 2.9 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
CHEMBL3545811 | 120644 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 305 | 1 | 2 | 1 | 2.9 | NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2 | 10.1016/j.bmc.2014.09.005 | |||
56944564 | 112122 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 480 | 8 | 1 | 6 | 4.3 | O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3289954 | 112122 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 480 | 8 | 1 | 6 | 4.3 | O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
24854185 | 157800 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 8 | 1 | 3 | 5.6 | CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
CHEMBL408191 | 157800 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 8 | 1 | 3 | 5.6 | CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm070279v | |||
44340834 | 110281 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 169 | 2 | ChEMBL | 494 | 6 | 1 | 6 | 4.0 | O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL323778 | 110281 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 169 | 2 | ChEMBL | 494 | 6 | 1 | 6 | 4.0 | O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/s0960-894x(02)00690-x | |||
155567938 | 176138 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 20 | 2 | ChEMBL | 386 | 8 | 2 | 5 | 2.8 | NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.ejmech.2019.111690 | |||
CHEMBL4590226 | 176138 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 20 | 2 | ChEMBL | 386 | 8 | 2 | 5 | 2.8 | NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.ejmech.2019.111690 | |||
10834268 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1021/jm0104264 | |||
CHEMBL428494 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1021/jm0104264 | |||
10834268 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1021/jm980519u | |||
CHEMBL428494 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1021/jm980519u | |||
168288462 | 191814 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 461 | 8 | 0 | 5 | 3.6 | COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL5196950 | 191814 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 461 | 8 | 0 | 5 | 3.6 | COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1 | 10.1021/acs.jmedchem.2c00633 | |||
60195993 | 81842 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 266 | 2 | 1 | 2 | 3.4 | Cc1ccc(-c2ccccc2N2CCNCC2)cc1C | 10.1021/jm3003679 | |||
CHEMBL2164334 | 81842 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 266 | 2 | 1 | 2 | 3.4 | Cc1ccc(-c2ccccc2N2CCNCC2)cc1C | 10.1021/jm3003679 | |||
3233 | 3512 | None | 28 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111690 | |||
3247 | 3512 | None | 28 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111690 | |||
6604889 | 3512 | None | 28 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111690 | |||
CHEMBL282199 | 3512 | None | 28 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111690 | |||
DB13988 | 3512 | None | 28 | Human | Binding | pKi | = | 8.7 | 8.7 | 2 | 17 | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1016/j.ejmech.2019.111690 | |||
56944383 | 112182 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | |||
CHEMBL3290012 | 112182 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -3 | 12 | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | |||
24854105 | 158025 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 401 | 6 | 1 | 3 | 4.5 | O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm070279v | |||
CHEMBL408450 | 158025 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 401 | 6 | 1 | 3 | 4.5 | O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm070279v | |||
155542678 | 173265 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 281 | 2 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL4521657 | 173265 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 281 | 2 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 | 10.1016/j.ejmech.2019.111705 | |||
10028436 | 3532 | None | 9 | Rat | Binding | pKi | = | 8.7 | 8.7 | 1 | 12 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/j.bmcl.2004.11.013 | |||
3237 | 3532 | None | 9 | Rat | Binding | pKi | = | 8.7 | 8.7 | 1 | 12 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/j.bmcl.2004.11.013 | |||
CHEMBL95104 | 3532 | None | 9 | Rat | Binding | pKi | = | 8.7 | 8.7 | 1 | 12 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/j.bmcl.2004.11.013 | |||
44396223 | 123877 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | 281 | 2 | ChEMBL | 486 | 7 | 0 | 4 | 5.0 | O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 | 10.1021/jm0498102 | |||
CHEMBL362354 | 123877 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | 281 | 2 | ChEMBL | 486 | 7 | 0 | 4 | 5.0 | O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1 | 10.1021/jm0498102 | |||
10573876 | 10465 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 199 | 7 | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm991151j | |||
CHEMBL116448 | 10465 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 199 | 7 | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm991151j | |||
8431 | 1484 | None | 11 | Human | Binding | pKi | = | 8.7 | 8.7 | 22 | 5 | ChEMBL | 386 | 6 | 1 | 2 | 5.2 | O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 | 10.1021/jm991151j | |||
9843179 | 1484 | None | 11 | Human | Binding | pKi | = | 8.7 | 8.7 | 22 | 5 | ChEMBL | 386 | 6 | 1 | 2 | 5.2 | O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 | 10.1021/jm991151j | |||
CHEMBL69257 | 1484 | None | 11 | Human | Binding | pKi | = | 8.7 | 8.7 | 22 | 5 | ChEMBL | 386 | 6 | 1 | 2 | 5.2 | O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 | 10.1021/jm991151j | |||
44368731 | 119755 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm030841r | |||
CHEMBL347286 | 119755 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 414 | 5 | 0 | 3 | 3.7 | CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1 | 10.1021/jm030841r | |||
11047374 | 18916 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 6 | 1 | 2 | 5.3 | O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL12846 | 18916 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 6 | 1 | 2 | 5.3 | O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
10834268 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL428494 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
8431 | 1484 | None | 11 | Human | Binding | pKi | = | 8.7 | 8.7 | 22 | 5 | ChEMBL | 386 | 6 | 1 | 2 | 5.2 | O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 | 10.1021/jm030841r | |||
9843179 | 1484 | None | 11 | Human | Binding | pKi | = | 8.7 | 8.7 | 22 | 5 | ChEMBL | 386 | 6 | 1 | 2 | 5.2 | O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 | 10.1021/jm030841r | |||
CHEMBL69257 | 1484 | None | 11 | Human | Binding | pKi | = | 8.7 | 8.7 | 22 | 5 | ChEMBL | 386 | 6 | 1 | 2 | 5.2 | O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2 | 10.1021/jm030841r | |||
10834268 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1021/jm030841r | |||
CHEMBL428494 | 166922 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 390 | 6 | 1 | 4 | 3.6 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3 | 10.1021/jm030841r | |||
10433930 | 51104 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 5 | ChEMBL | 449 | 5 | 2 | 5 | 3.9 | COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
CHEMBL157910 | 51104 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 5 | ChEMBL | 449 | 5 | 2 | 5 | 3.9 | COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | |||
10028436 | 3532 | None | 9 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
3237 | 3532 | None | 9 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
CHEMBL95104 | 3532 | None | 9 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | |||
46203758 | 124615 | None | 0 | Rat | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 339 | 5 | 1 | 4 | 3.6 | COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 | nan | |||
CHEMBL3640556 | 124615 | None | 0 | Rat | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 339 | 5 | 1 | 4 | 3.6 | COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 | nan | |||
44393072 | 169379 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 353 | 8 | 2 | 6 | 3.7 | C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.008 | |||
CHEMBL441312 | 169379 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 353 | 8 | 2 | 6 | 3.7 | C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1 | 10.1016/j.bmcl.2004.06.008 | |||
2389 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
5073 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
5073.0 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
96 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
DB00734 | 3331 | None | 72 | Human | Binding | pKi | = | 8 | 8.0 | -7 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
10171 | 56 | None | 11 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 6 | ChEMBL | 401 | 3 | 1 | 2 | 3.7 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC | 10.1016/s0960-894x(00)00166-9 | |||
272 | 56 | None | 11 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 6 | ChEMBL | 401 | 3 | 1 | 2 | 3.7 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL274384 | 56 | None | 11 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 6 | ChEMBL | 401 | 3 | 1 | 2 | 3.7 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC | 10.1016/s0960-894x(00)00166-9 | |||
10499156 | 114155 | None | 1 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 366 | 6 | 0 | 4 | 3.0 | COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm991151j | |||
CHEMBL332701 | 114155 | None | 1 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 366 | 6 | 0 | 4 | 3.0 | COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm991151j | |||
10249573 | 210052 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 11 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm991151j | |||
CHEMBL94984 | 210052 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 11 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm991151j | |||
44368705 | 45882 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 366 | 6 | 0 | 4 | 3.0 | COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm030841r | |||
CHEMBL153156 | 45882 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 366 | 6 | 0 | 4 | 3.0 | COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1 | 10.1021/jm030841r | |||
10596321 | 209923 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm030841r | |||
CHEMBL94261 | 209923 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm030841r | |||
44460708 | 208066 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 331 | 3 | 0 | 3 | 3.9 | Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 | 10.1021/jm030030n | |||
CHEMBL81607 | 208066 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 331 | 3 | 0 | 3 | 3.9 | Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 | 10.1021/jm030030n | |||
10249573 | 210052 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 11 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm030030n | |||
CHEMBL94984 | 210052 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 11 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm030030n | |||
44461065 | 208002 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 389 | 4 | 0 | 3 | 4.4 | Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1 | 10.1016/s0960-894x(02)00438-9 | |||
CHEMBL81022 | 208002 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 389 | 4 | 0 | 3 | 4.4 | Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1 | 10.1016/s0960-894x(02)00438-9 | |||
44460708 | 208066 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 331 | 3 | 0 | 3 | 3.9 | Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 | 10.1016/s0960-894x(02)00438-9 | |||
CHEMBL81607 | 208066 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 331 | 3 | 0 | 3 | 3.9 | Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1 | 10.1016/s0960-894x(02)00438-9 | |||
10249573 | 210052 | None | 0 | Rat | Binding | pKi | = | 8 | 8.0 | -1 | 11 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm049743b | |||
CHEMBL94984 | 210052 | None | 0 | Rat | Binding | pKi | = | 8 | 8.0 | -1 | 11 | ChEMBL | 386 | 5 | 0 | 3 | 4.1 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1 | 10.1021/jm049743b | |||
5 | 139 | None | 45 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030030n | |||
5202 | 139 | None | 45 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030030n | |||
CHEMBL39 | 139 | None | 45 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030030n | |||
DB08839 | 139 | None | 45 | Rat | Binding | pKi | = | 8 | 8.0 | -5 | 54 | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm030030n | |||
9894665 | 103868 | None | 1 | Human | Binding | pKi | = | 8 | 8.0 | -30 | 8 | ChEMBL | 585 | 10 | 2 | 8 | 3.3 | CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 | 10.1021/jm9905918 | |||
CHEMBL309106 | 103868 | None | 1 | Human | Binding | pKi | = | 8 | 8.0 | -30 | 8 | ChEMBL | 585 | 10 | 2 | 8 | 3.3 | CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 | 10.1021/jm9905918 | |||
46203758 | 124615 | None | 0 | Rat | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 339 | 5 | 1 | 4 | 3.6 | COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 | nan | |||
CHEMBL3640556 | 124615 | None | 0 | Rat | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 339 | 5 | 1 | 4 | 3.6 | COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1 | nan | |||
CHEMBL5074880 | 216827 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 9 | ChEMBL | None | None | None | CCNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
127028472 | 138258 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 9 | 3 | ChEMBL | 470 | 8 | 2 | 6 | 2.2 | CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3769534 | 138258 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 9 | 3 | ChEMBL | 470 | 8 | 2 | 6 | 2.2 | CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1 | 10.1016/j.ejmech.2016.02.024 | |||
127038281 | 137174 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 494 | 10 | 0 | 6 | 4.0 | Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1 | 10.1016/j.bmc.2015.11.041 | |||
CHEMBL3747240 | 137174 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 494 | 10 | 0 | 6 | 4.0 | Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1 | 10.1016/j.bmc.2015.11.041 | |||
127041259 | 137185 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 4 | 4 | ChEMBL | 420 | 8 | 0 | 6 | 2.7 | CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1 | 10.1016/j.bmc.2015.11.041 | |||
CHEMBL3747459 | 137185 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 4 | 4 | ChEMBL | 420 | 8 | 0 | 6 | 2.7 | CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1 | 10.1016/j.bmc.2015.11.041 | |||
145985505 | 165720 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 5 | ChEMBL | 491 | 6 | 0 | 7 | 3.7 | O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4243579 | 165720 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -3 | 5 | ChEMBL | 491 | 6 | 0 | 7 | 3.7 | O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
134145903 | 148966 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 5 | 4 | ChEMBL | 455 | 10 | 1 | 3 | 5.9 | C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 | 10.1016/j.ejmech.2016.05.005 | |||
CHEMBL3941529 | 148966 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 5 | 4 | ChEMBL | 455 | 10 | 1 | 3 | 5.9 | C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 | 10.1016/j.ejmech.2016.05.005 | |||
71456781 | 81459 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 428 | 8 | 1 | 5 | 3.8 | O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159471 | 81459 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 428 | 8 | 1 | 5 | 3.8 | O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1 | 10.1016/j.ejmech.2012.07.043 | |||
71458651 | 81465 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 439 | 8 | 1 | 5 | 3.8 | CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159477 | 81465 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 439 | 8 | 1 | 5 | 3.8 | CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1 | 10.1016/j.ejmech.2012.07.043 | |||
71456784 | 81480 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 440 | 8 | 1 | 4 | 3.9 | O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159492 | 81480 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 1 | 4 | ChEMBL | 440 | 8 | 1 | 4 | 3.9 | O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1 | 10.1016/j.ejmech.2012.07.043 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 8 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2022.114193 | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 8 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2022.114193 | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 8 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2022.114193 | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 8 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2022.114193 | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 8 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2022.114193 | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 8 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2022.114193 | |||
118731352 | 118253 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 2 | 2 | ChEMBL | 510 | 9 | 1 | 4 | 4.5 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409036 | 118253 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 2 | 2 | ChEMBL | 510 | 9 | 1 | 4 | 4.5 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
118731362 | 118262 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 4 | 2 | ChEMBL | 564 | 8 | 0 | 4 | 5.6 | O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409045 | 118262 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 4 | 2 | ChEMBL | 564 | 8 | 0 | 4 | 5.6 | O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
145947590 | 167805 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 8 | 3 | ChEMBL | 516 | 7 | 2 | 6 | 2.4 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1 | 10.1016/j.ejmech.2018.01.093 | |||
CHEMBL4170657 | 167805 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 8 | 3 | ChEMBL | 516 | 7 | 2 | 6 | 2.4 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1 | 10.1016/j.ejmech.2018.01.093 | |||
CHEMBL4302436 | 167805 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 8 | 3 | ChEMBL | 516 | 7 | 2 | 6 | 2.4 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1 | 10.1016/j.ejmech.2018.01.093 | |||
145947976 | 167816 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 41 | 3 | ChEMBL | 438 | 7 | 2 | 6 | 1.6 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 | 10.1016/j.ejmech.2018.01.093 | |||
CHEMBL4168743 | 167816 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 41 | 3 | ChEMBL | 438 | 7 | 2 | 6 | 1.6 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 | 10.1016/j.ejmech.2018.01.093 | |||
CHEMBL4302539 | 167816 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 41 | 3 | ChEMBL | 438 | 7 | 2 | 6 | 1.6 | COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1 | 10.1016/j.ejmech.2018.01.093 | |||
56944952 | 157459 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -2 | 4 | ChEMBL | 447 | 7 | 2 | 3 | 4.4 | O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL4077937 | 157459 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -2 | 4 | ChEMBL | 447 | 7 | 2 | 3 | 4.4 | O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.7b00839 | |||
24854103 | 96208 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 463 | 7 | 1 | 3 | 5.7 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 | 10.1021/jm200547z | |||
CHEMBL260551 | 96208 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 463 | 7 | 1 | 3 | 5.7 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21 | 10.1021/jm200547z | |||
127052458 | 140827 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 3 | 7 | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL3818056 | 140827 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 3 | 7 | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | |||
90644074 | 112135 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 151 | 4 | ChEMBL | 414 | 7 | 1 | 6 | 2.6 | Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
CHEMBL3289967 | 112135 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 151 | 4 | ChEMBL | 414 | 7 | 1 | 6 | 2.6 | Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm401895u | |||
56943695 | 112185 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -4 | 4 | ChEMBL | 505 | 7 | 1 | 6 | 5.2 | Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 | 10.1021/jm401895u | |||
CHEMBL3290015 | 112185 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -4 | 4 | ChEMBL | 505 | 7 | 1 | 6 | 5.2 | Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12 | 10.1021/jm401895u | |||
10171 | 56 | None | 11 | Human | Binding | pKi | = | 8 | 8.0 | -11 | 6 | ChEMBL | 401 | 3 | 1 | 2 | 3.7 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC | 10.1021/jm030841r | |||
272 | 56 | None | 11 | Human | Binding | pKi | = | 8 | 8.0 | -11 | 6 | ChEMBL | 401 | 3 | 1 | 2 | 3.7 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC | 10.1021/jm030841r | |||
CHEMBL274384 | 56 | None | 11 | Human | Binding | pKi | = | 8 | 8.0 | -11 | 6 | ChEMBL | 401 | 3 | 1 | 2 | 3.7 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC | 10.1021/jm030841r | |||
90656682 | 111041 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 311 | 6 | 2 | 4 | 3.0 | Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262411 | 111041 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 311 | 6 | 2 | 4 | 3.0 | Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2014.04.034 | |||
11525867 | 96279 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 479 | 7 | 1 | 3 | 6.2 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 | 10.1021/jm070279v | |||
CHEMBL260870 | 96279 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 479 | 7 | 1 | 3 | 6.2 | CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21 | 10.1021/jm070279v | |||
44266289 | 98216 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 404 | 4 | 1 | 5 | 3.5 | O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL273872 | 98216 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 404 | 4 | 1 | 5 | 3.5 | O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
127052458 | 140827 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 7 | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL3818056 | 140827 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 7 | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 8.0 | 8.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | |||
10714877 | 114436 | None | 1 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 381 | 7 | 0 | 6 | 3.2 | COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL3331256 | 114436 | None | 1 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 381 | 7 | 0 | 6 | 3.2 | COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
11825614 | 102665 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 403 | 6 | 1 | 3 | 4.5 | Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 | 10.1021/jm0104264 | |||
CHEMBL304167 | 102665 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 403 | 6 | 1 | 3 | 4.5 | Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1 | 10.1021/jm0104264 | |||
46204726 | 124634 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 327 | 3 | 1 | 2 | 4.4 | FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 | nan | |||
CHEMBL3640574 | 124634 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 327 | 3 | 1 | 2 | 4.4 | FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 | nan | |||
46204726 | 124634 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 327 | 3 | 1 | 2 | 4.4 | FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 | nan | |||
CHEMBL3640574 | 124634 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 327 | 3 | 1 | 2 | 4.4 | FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1 | nan | |||
134155476 | 151314 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 7 | 4 | ChEMBL | 455 | 10 | 1 | 3 | 5.9 | C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 | 10.1016/j.ejmech.2016.05.005 | |||
CHEMBL3960056 | 151314 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 7 | 4 | ChEMBL | 455 | 10 | 1 | 3 | 5.9 | C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1 | 10.1016/j.ejmech.2016.05.005 | |||
2726 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
2726.0 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
621 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
83 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
DB00477 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
76336186 | 106458 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 397 | 5 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 | 10.1016/j.ejmech.2014.01.055 | |||
CHEMBL3121435 | 106458 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 397 | 5 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 | 10.1016/j.ejmech.2014.01.055 | |||
CHEMBL3139448 | 106458 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 397 | 5 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1 | 10.1016/j.ejmech.2014.01.055 | |||
11667458 | 66020 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | 350 | 6 | 1 | 4 | 3.1 | O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1 | 10.1021/jm200547z | |||
CHEMBL1836788 | 66020 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | 350 | 6 | 1 | 4 | 3.1 | O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1 | 10.1021/jm200547z | |||
11407754 | 98234 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 429 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL273982 | 98234 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 429 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 | 10.1016/s0960-894x(00)00166-9 | |||
49850870 | 56405 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -794 | 9 | ChEMBL | 424 | 6 | 1 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
CHEMBL1631535 | 56405 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -794 | 9 | ChEMBL | 424 | 6 | 1 | 5 | 3.3 | Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm100714c | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 7 | 7.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 7 | 7.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 7 | 7.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 7 | 7.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 7 | 7.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 7 | 7.0 | -15 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 7 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 7 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 7 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 7 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 7 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 7 | 7.0 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
11407754 | 98234 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 429 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 | 10.1021/jm030841r | |||
CHEMBL273982 | 98234 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 429 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1 | 10.1021/jm030841r | |||
44374234 | 55571 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 12 | 2 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1ccnc(-c2ccccc2)c1 | 10.1016/j.bmcl.2003.11.050 | |||
CHEMBL162071 | 55571 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 12 | 2 | ChEMBL | 258 | 5 | 0 | 3 | 3.4 | CN(C)CCSc1ccnc(-c2ccccc2)c1 | 10.1016/j.bmcl.2003.11.050 | |||
10737314 | 97324 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 361 | 4 | 1 | 3 | 3.4 | O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL268921 | 97324 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 361 | 4 | 1 | 3 | 3.4 | O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
10737314 | 97324 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 361 | 4 | 1 | 3 | 3.4 | O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 | 10.1021/jm030841r | |||
CHEMBL268921 | 97324 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 361 | 4 | 1 | 3 | 3.4 | O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 | 10.1021/jm030841r | |||
11166042 | 166464 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -2 | 3 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/jm049743b | |||
CHEMBL427518 | 166464 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -2 | 3 | ChEMBL | 419 | 9 | 1 | 6 | 2.2 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/jm049743b | |||
135 | 2532 | None | 33 | Rat | Binding | pKi | = | 7 | 7.0 | -50 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm030030n | |||
1796 | 2532 | None | 33 | Rat | Binding | pKi | = | 7 | 7.0 | -50 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm030030n | |||
4184 | 2532 | None | 33 | Rat | Binding | pKi | = | 7 | 7.0 | -50 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm030030n | |||
4184.0 | 2532 | None | 33 | Rat | Binding | pKi | = | 7 | 7.0 | -50 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm030030n | |||
CHEMBL6437 | 2532 | None | 33 | Rat | Binding | pKi | = | 7 | 7.0 | -50 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm030030n | |||
DB06148 | 2532 | None | 33 | Rat | Binding | pKi | = | 7 | 7.0 | -50 | 57 | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm030030n | |||
CHEMBL5071978 | 216760 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -1 | 6 | ChEMBL | None | None | None | CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
127041874 | 137134 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -2 | 4 | ChEMBL | 450 | 8 | 0 | 4 | 4.5 | CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1 | 10.1016/j.bmc.2015.11.041 | |||
CHEMBL3746713 | 137134 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -2 | 4 | ChEMBL | 450 | 8 | 0 | 4 | 4.5 | CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1 | 10.1016/j.bmc.2015.11.041 | |||
145975905 | 163923 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 5 | 4 | ChEMBL | 376 | 4 | 1 | 4 | 2.4 | O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2 | 10.1016/j.bmcl.2018.06.019 | |||
CHEMBL4206366 | 163923 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 5 | 4 | ChEMBL | 376 | 4 | 1 | 4 | 2.4 | O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2 | 10.1016/j.bmcl.2018.06.019 | |||
11414582 | 181444 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -16 | 4 | ChEMBL | 271 | 2 | 1 | 3 | 2.7 | Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 | 10.1016/j.bmcl.2020.127669 | |||
CHEMBL4762886 | 181444 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -16 | 4 | ChEMBL | 271 | 2 | 1 | 3 | 2.7 | Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1 | 10.1016/j.bmcl.2020.127669 | |||
2470 | 3653 | None | 40 | Human | Binding | pKi | = | 7 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.ejmech.2019.111705 | |||
3300 | 3653 | None | 40 | Human | Binding | pKi | = | 7 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.ejmech.2019.111705 | |||
5265 | 3653 | None | 40 | Human | Binding | pKi | = | 7 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.ejmech.2019.111705 | |||
99 | 3653 | None | 40 | Human | Binding | pKi | = | 7 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL267930 | 3653 | None | 40 | Human | Binding | pKi | = | 7 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.ejmech.2019.111705 | |||
44439409 | 91250 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 15 | 3 | ChEMBL | 322 | 5 | 0 | 3 | 4.0 | CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21 | 10.1016/j.bmcl.2007.01.093 | |||
CHEMBL240025 | 91250 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 15 | 3 | ChEMBL | 322 | 5 | 0 | 3 | 4.0 | CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21 | 10.1016/j.bmcl.2007.01.093 | |||
44439404 | 91819 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 15 | 3 | ChEMBL | 334 | 3 | 0 | 3 | 4.0 | CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 | 10.1016/j.bmcl.2007.01.093 | |||
CHEMBL241103 | 91819 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 15 | 3 | ChEMBL | 334 | 3 | 0 | 3 | 4.0 | CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21 | 10.1016/j.bmcl.2007.01.093 | |||
21509921 | 104514 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -9 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104091 | 104514 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -9 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
11808247 | 18082 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -1 | 9 | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL126667 | 18082 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -1 | 9 | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL3819366 | 18082 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -1 | 9 | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
9888211 | 21423 | None | 17 | Human | Binding | pKi | = | 7 | 7.0 | -125 | 10 | ChEMBL | 417 | 6 | 1 | 3 | 4.5 | O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 | 10.1021/jm070516u | |||
CHEMBL131495 | 21423 | None | 17 | Human | Binding | pKi | = | 7 | 7.0 | -125 | 10 | ChEMBL | 417 | 6 | 1 | 3 | 4.5 | O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 | 10.1021/jm070516u | |||
10317515 | 99813 | None | 1 | Rat | Binding | pKi | = | 7 | 7.0 | -19 | 3 | ChEMBL | 378 | 3 | 0 | 4 | 1.8 | O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 | 10.1016/s0960-894x(03)00160-4 | |||
CHEMBL285066 | 99813 | None | 1 | Rat | Binding | pKi | = | 7 | 7.0 | -19 | 3 | ChEMBL | 378 | 3 | 0 | 4 | 1.8 | O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 | 10.1016/s0960-894x(03)00160-4 | |||
46204086 | 124622 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 269 | 4 | 1 | 3 | 3.0 | COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 | nan | |||
CHEMBL3640562 | 124622 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 269 | 4 | 1 | 3 | 3.0 | COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 | nan | |||
11327643 | 119646 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | 1 | 2 | ChEMBL | 421 | 6 | 0 | 4 | 4.0 | O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2019.06.028 | |||
CHEMBL346191 | 119646 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | 1 | 2 | ChEMBL | 421 | 6 | 0 | 4 | 4.0 | O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2019.06.028 | |||
240 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
2769 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
44279790 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
660 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
CHEMBL1729 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
CHEMBL560739 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
DB00604 | 944 | None | 25 | Human | Binding | pKi | = | 6 | 6.0 | -199 | 25 | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | |||
135398745 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
47 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
DB00334 | 2914 | None | 65 | Human | Binding | pKi | = | 6 | 6.0 | -95 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
2337 | 3256 | None | 51 | Human | Binding | pKi | = | 6 | 6.0 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | |||
50 | 3256 | None | 51 | Human | Binding | pKi | = | 6 | 6.0 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | |||
5002 | 3256 | None | 51 | Human | Binding | pKi | = | 6 | 6.0 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | |||
5002.0 | 3256 | None | 51 | Human | Binding | pKi | = | 6 | 6.0 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | |||
CHEMBL716 | 3256 | None | 51 | Human | Binding | pKi | = | 6 | 6.0 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | |||
DB01224 | 3256 | None | 51 | Human | Binding | pKi | = | 6 | 6.0 | -28 | 62 | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | |||
11327643 | 119646 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | -1 | 2 | ChEMBL | 421 | 6 | 0 | 4 | 4.0 | O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1021/jm030841r | |||
CHEMBL346191 | 119646 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | -1 | 2 | ChEMBL | 421 | 6 | 0 | 4 | 4.0 | O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1021/jm030841r | |||
9827938 | 11775 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -39 | 12 | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | |||
CHEMBL1181680 | 11775 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -39 | 12 | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | |||
CHEMBL188486 | 11775 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -39 | 12 | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | |||
46204086 | 124622 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 269 | 4 | 1 | 3 | 3.0 | COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 | nan | |||
CHEMBL3640562 | 124622 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 269 | 4 | 1 | 3 | 3.0 | COc1ccc(-c2cccc(C)c2)cc1OC1CNC1 | nan | |||
10125797 | 161905 | None | 6 | Human | Binding | pKi | = | 6 | 6.0 | -407 | 4 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 | 10.1016/j.bmc.2019.115262 | |||
CHEMBL41436 | 161905 | None | 6 | Human | Binding | pKi | = | 6 | 6.0 | -407 | 4 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 | 10.1016/j.bmc.2019.115262 | |||
CHEMBL541621 | 161905 | None | 6 | Human | Binding | pKi | = | 6 | 6.0 | -407 | 4 | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 | 10.1016/j.bmc.2019.115262 | |||
153287574 | 175351 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -13 | 10 | ChEMBL | 266 | 2 | 1 | 2 | 4.0 | CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | |||
CHEMBL4572167 | 175351 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -13 | 10 | ChEMBL | 266 | 2 | 1 | 2 | 4.0 | CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | |||
146709966 | 175883 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -338 | 3 | ChEMBL | 241 | 1 | 1 | 2 | 3.4 | CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | |||
CHEMBL4583909 | 175883 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -338 | 3 | ChEMBL | 241 | 1 | 1 | 2 | 3.4 | CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | |||
153287539 | 176178 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -3 | 2 | ChEMBL | 265 | 1 | 1 | 2 | 3.6 | C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2 | 10.1021/acsmedchemlett.9b00225 | |||
CHEMBL4591008 | 176178 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -3 | 2 | ChEMBL | 265 | 1 | 1 | 2 | 3.6 | C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2 | 10.1021/acsmedchemlett.9b00225 | |||
2543 | 3707 | None | 46 | Human | Binding | pKi | = | 6 | 6.0 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.ejmech.2019.111705 | |||
5358 | 3707 | None | 46 | Human | Binding | pKi | = | 6 | 6.0 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.ejmech.2019.111705 | |||
5358.0 | 3707 | None | 46 | Human | Binding | pKi | = | 6 | 6.0 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.ejmech.2019.111705 | |||
54 | 3707 | None | 46 | Human | Binding | pKi | = | 6 | 6.0 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.ejmech.2019.111705 | |||
CHEMBL128 | 3707 | None | 46 | Human | Binding | pKi | = | 6 | 6.0 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.ejmech.2019.111705 | |||
DB00669 | 3707 | None | 46 | Human | Binding | pKi | = | 6 | 6.0 | -93 | 31 | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1016/j.ejmech.2019.111705 | |||
44439403 | 91818 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -5 | 3 | ChEMBL | 394 | 5 | 0 | 5 | 4.0 | COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2 | 10.1016/j.bmcl.2007.01.093 | |||
CHEMBL241102 | 91818 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -5 | 3 | ChEMBL | 394 | 5 | 0 | 5 | 4.0 | COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2 | 10.1016/j.bmcl.2007.01.093 | |||
76524414 | 140956 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -77 | 8 | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL3819434 | 140956 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -77 | 8 | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL3819713 | 140956 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -77 | 8 | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | |||
9913554 | 101046 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -1258 | 14 | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
CHEMBL29433 | 101046 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -1258 | 14 | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
46204732 | 124638 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 250 | 3 | 1 | 3 | 2.6 | N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 | nan | |||
CHEMBL3640578 | 124638 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 250 | 3 | 1 | 3 | 2.6 | N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 | nan | |||
46204734 | 124641 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 264 | 3 | 1 | 3 | 2.9 | Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 | nan | |||
CHEMBL3640580 | 124641 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 264 | 3 | 1 | 3 | 2.9 | Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 | nan | |||
46205044 | 124646 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 297 | 5 | 1 | 3 | 3.8 | Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 | nan | |||
CHEMBL3640585 | 124646 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 297 | 5 | 1 | 3 | 3.8 | Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 | nan | |||
10668422 | 98218 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 395 | 6 | 1 | 3 | 4.3 | O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL273890 | 98218 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 395 | 6 | 1 | 3 | 4.3 | O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 | 10.1016/s0960-894x(00)00166-9 | |||
10643153 | 98576 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 374 | 6 | 0 | 3 | 4.0 | C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL276255 | 98576 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 374 | 6 | 0 | 3 | 4.0 | C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1 | 10.1016/s0960-894x(00)00166-9 | |||
46204732 | 124638 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 250 | 3 | 1 | 3 | 2.6 | N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 | nan | |||
CHEMBL3640578 | 124638 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 250 | 3 | 1 | 3 | 2.6 | N#Cc1ccc(-c2ccccc2)cc1OC1CNC1 | nan | |||
46204734 | 124641 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 264 | 3 | 1 | 3 | 2.9 | Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 | nan | |||
CHEMBL3640580 | 124641 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 264 | 3 | 1 | 3 | 2.9 | Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1 | nan | |||
46205044 | 124646 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 297 | 5 | 1 | 3 | 3.8 | Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 | nan | |||
CHEMBL3640585 | 124646 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 297 | 5 | 1 | 3 | 3.8 | Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1 | nan | |||
13149 | 2545 | None | 18 | Human | Binding | pKi | = | 5 | 5.0 | -165 | 17 | ChEMBL | 398 | 5 | 1 | 5 | 3.8 | CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC | 10.1021/acs.jmedchem.1c00726 | |||
3034396 | 2545 | None | 18 | Human | Binding | pKi | = | 5 | 5.0 | -165 | 17 | ChEMBL | 398 | 5 | 1 | 5 | 3.8 | CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC | 10.1021/acs.jmedchem.1c00726 | |||
CHEMBL299031 | 2545 | None | 18 | Human | Binding | pKi | = | 5 | 5.0 | -165 | 17 | ChEMBL | 398 | 5 | 1 | 5 | 3.8 | CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC | 10.1021/acs.jmedchem.1c00726 | |||
11462900 | 57026 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 372 | 4 | 1 | 3 | 4.7 | FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
CHEMBL1644270 | 57026 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 372 | 4 | 1 | 3 | 4.7 | FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
53316608 | 57032 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 344 | 3 | 1 | 2 | 5.1 | CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
CHEMBL1644276 | 57032 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 344 | 3 | 1 | 2 | 5.1 | CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
53316609 | 57033 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 322 | 3 | 1 | 2 | 4.5 | Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1 | 10.1016/j.bmcl.2010.11.078 | |||
CHEMBL1644277 | 57033 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 322 | 3 | 1 | 2 | 4.5 | Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1 | 10.1016/j.bmcl.2010.11.078 | |||
11449570 | 57037 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 304 | 3 | 2 | 3 | 3.6 | Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
CHEMBL1644281 | 57037 | None | 0 | Rat | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 304 | 3 | 2 | 3 | 3.6 | Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
25229646 | 63565 | None | 25 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 388 | 4 | 1 | 6 | 2.5 | N#CC1(c2ccccn2)CCN(Cc2cc(C(=O)O)c(=O)n3ccccc23)CC1 | 10.6019/CHEMBL4507295 | |||
CHEMBL1800285 | 63565 | None | 25 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 388 | 4 | 1 | 6 | 2.5 | N#CC1(c2ccccn2)CCN(Cc2cc(C(=O)O)c(=O)n3ccccc23)CC1 | 10.6019/CHEMBL4507295 | |||
CHEMBL4584981 | 216496 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | None | None | None | CO[C@@H](C)c1c(Nc2ccc([C@@H](N(C)C(=O)C3CCS(=O)(=O)CC3)C(F)(F)F)cc2)cnc2cc(Cl)nn12 | 10.6019/CHEMBL4507320 | |||||
3251 | 4072 | None | 43 | Human | Binding | pKi | = | 5 | 5.0 | -33113 | 12 | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
5684 | 4072 | None | 43 | Human | Binding | pKi | = | 5 | 5.0 | -33113 | 12 | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
80 | 4072 | None | 43 | Human | Binding | pKi | = | 5 | 5.0 | -33113 | 12 | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
CHEMBL31354 | 4072 | None | 43 | Human | Binding | pKi | = | 5 | 5.0 | -33113 | 12 | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | |||
44368373 | 119622 | None | 0 | Human | Binding | pKi | = | 4 | 4.0 | - | 1 | ChEMBL | 373 | 6 | 0 | 3 | 4.8 | CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12 | 10.1021/jm030841r | |||
CHEMBL345971 | 119622 | None | 0 | Human | Binding | pKi | = | 4 | 4.0 | - | 1 | ChEMBL | 373 | 6 | 0 | 3 | 4.8 | CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12 | 10.1021/jm030841r | |||
10668422 | 98218 | None | 0 | Human | Binding | pKi | = | 4 | 4.0 | - | 1 | ChEMBL | 395 | 6 | 1 | 3 | 4.3 | O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 | 10.1021/jm030841r | |||
CHEMBL273890 | 98218 | None | 0 | Human | Binding | pKi | = | 4 | 4.0 | - | 1 | ChEMBL | 395 | 6 | 1 | 3 | 4.3 | O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3 | 10.1021/jm030841r | |||
171355796 | 194280 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -1 | 3 | ChEMBL | 422 | 7 | 0 | 5 | 3.5 | O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmc.2023.117256 | |||
CHEMBL5282788 | 194280 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -1 | 3 | ChEMBL | 422 | 7 | 0 | 5 | 3.5 | O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmc.2023.117256 | |||
76524414 | 140956 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -77 | 8 | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL3819434 | 140956 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -77 | 8 | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL3819713 | 140956 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -77 | 8 | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | |||
118724647 | 120670 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -5 | 4 | ChEMBL | 381 | 6 | 0 | 7 | 1.7 | Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
CHEMBL3361004 | 120670 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -5 | 4 | ChEMBL | 381 | 6 | 0 | 7 | 1.7 | Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
CHEMBL3546104 | 120670 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -5 | 4 | ChEMBL | 381 | 6 | 0 | 7 | 1.7 | Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
11603887 | 102645 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -3 | 2 | ChEMBL | 407 | 10 | 1 | 4 | 3.5 | O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1 | 10.1021/jm400766k | |||
CHEMBL2431046 | 102645 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -3 | 2 | ChEMBL | 407 | 10 | 1 | 4 | 3.5 | O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1 | 10.1021/jm400766k | |||
CHEMBL3040877 | 102645 | None | 0 | Rat | Binding | pKi | = | 7 | 7.0 | -3 | 2 | ChEMBL | 407 | 10 | 1 | 4 | 3.5 | O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1 | 10.1021/jm400766k | |||
90654670 | 110147 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 1 | 2 | ChEMBL | 427 | 9 | 1 | 6 | 2.4 | NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235742 | 110147 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 1 | 2 | ChEMBL | 427 | 9 | 1 | 6 | 2.4 | NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
136180321 | 117779 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 1 | 2 | ChEMBL | 410 | 7 | 1 | 4 | 4.1 | O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 | 10.1016/j.bmcl.2015.02.042 | |||
CHEMBL3401483 | 117779 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 1 | 2 | ChEMBL | 410 | 7 | 1 | 4 | 4.1 | O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 | 10.1016/j.bmcl.2015.02.042 | |||
11291892 | 133582 | None | 3 | Rat | Binding | pKi | = | 7 | 7.0 | -24 | 3 | ChEMBL | 378 | 3 | 0 | 4 | 1.8 | O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 | 10.1021/jm048999e | |||
CHEMBL370758 | 133582 | None | 3 | Rat | Binding | pKi | = | 7 | 7.0 | -24 | 3 | ChEMBL | 378 | 3 | 0 | 4 | 1.8 | O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1 | 10.1021/jm048999e | |||
10994400 | 207579 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -109 | 4 | ChEMBL | 439 | 5 | 1 | 2 | 4.4 | OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 | 10.1021/jm0200411 | |||
CHEMBL77855 | 207579 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -109 | 4 | ChEMBL | 439 | 5 | 1 | 2 | 4.4 | OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1 | 10.1021/jm0200411 | |||
2880253 | 162802 | None | 6 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 3 | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1 | 10.1016/j.ejmech.2018.04.010 | |||
CHEMBL4170813 | 162802 | None | 6 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 3 | ChEMBL | 351 | 7 | 1 | 2 | 5.4 | CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1 | 10.1016/j.ejmech.2018.04.010 | |||
71457409 | 82994 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -3981 | 5 | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
CHEMBL2181168 | 82994 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -3981 | 5 | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | |||
134147951 | 149892 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 271 | 5 | 0 | 3 | 3.4 | COc1ccccc1-c1cc(CN(C)C)ccc1OC | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3948597 | 149892 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 271 | 5 | 0 | 3 | 3.4 | COc1ccccc1-c1cc(CN(C)C)ccc1OC | 10.1016/j.ejmech.2016.07.029 | |||
10737314 | 97324 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 361 | 4 | 1 | 3 | 3.4 | O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 | 10.1021/jm980519u | |||
CHEMBL268921 | 97324 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 361 | 4 | 1 | 3 | 3.4 | O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3 | 10.1021/jm980519u | |||
CHEMBL5076882 | 216954 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -26 | 4 | ChEMBL | None | None | None | C[C@H]1C[C@H](NS(=O)(=O)c2cccc(Cl)c2)CN1CCCc1noc2cc(F)ccc12 | 10.1021/acs.jmedchem.1c00497 | |||||
CHEMBL5083505 | 217355 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -2 | 4 | ChEMBL | None | None | None | O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00497 | |||||
1534 | 103095 | None | 23 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 12 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
9287 | 103095 | None | 23 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 12 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
CHEMBL30713 | 103095 | None | 23 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 12 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
10314060 | 168703 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -72 | 7 | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/s0960-894x(01)00241-4 | |||
CHEMBL435949 | 168703 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -72 | 7 | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/s0960-894x(01)00241-4 | |||
122442272 | 138435 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 15 | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | |||
CHEMBL3769968 | 138435 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 15 | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | |||
CHEMBL3771384 | 138435 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 15 | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | |||
18137015 | 164435 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 2 | ChEMBL | 394 | 7 | 1 | 4 | 3.2 | O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00828 | |||
CHEMBL4212558 | 164435 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 2 | ChEMBL | 394 | 7 | 1 | 4 | 3.2 | O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00828 | |||
23369457 | 189624 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -2 | 2 | ChEMBL | 322 | 4 | 1 | 4 | 2.2 | O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2009.02.008 | |||
CHEMBL514058 | 189624 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -2 | 2 | ChEMBL | 322 | 4 | 1 | 4 | 2.2 | O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2009.02.008 | |||
10754042 | 99854 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | 2 | 4 | ChEMBL | 263 | 0 | 1 | 2 | 2.8 | CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O | 10.1021/jm9911433 | |||
CHEMBL285352 | 99854 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | 2 | 4 | ChEMBL | 263 | 0 | 1 | 2 | 2.8 | CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O | 10.1021/jm9911433 | |||
1534 | 103095 | None | 23 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 12 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
9287 | 103095 | None | 23 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 12 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
CHEMBL30713 | 103095 | None | 23 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 12 | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
134135372 | 144485 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 295 | 4 | 0 | 2 | 4.6 | COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1 | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3906019 | 144485 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 295 | 4 | 0 | 2 | 4.6 | COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1 | 10.1016/j.ejmech.2016.07.029 | |||
168291659 | 192147 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 5 | ChEMBL | 356 | 8 | 3 | 8 | 1.4 | Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1 | 10.1016/j.ejmech.2021.113931 | |||
CHEMBL5202120 | 192147 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 5 | ChEMBL | 356 | 8 | 3 | 8 | 1.4 | Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1 | 10.1016/j.ejmech.2021.113931 | |||
135414318 | 210244 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 298 | 0 | 1 | 5 | 3.1 | CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1 | 10.1021/jm030030n | |||
CHEMBL96055 | 210244 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 298 | 0 | 1 | 5 | 3.1 | CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1 | 10.1021/jm030030n | |||
145978146 | 164011 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 4 | 2 | ChEMBL | 450 | 9 | 2 | 5 | 3.1 | CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2017.03.057 | |||
CHEMBL4207310 | 164011 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 4 | 2 | ChEMBL | 450 | 9 | 2 | 5 | 3.1 | CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2017.03.057 | |||
156013326 | 177599 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 3 | ChEMBL | 350 | 4 | 1 | 4 | 3.8 | COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL4639400 | 177599 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 3 | ChEMBL | 350 | 4 | 1 | 4 | 3.8 | COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2 | 10.1016/j.bmc.2020.115578 | |||
124247485 | 164164 | None | 6 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 8 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4209274 | 164164 | None | 6 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 8 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
124247485 | 164164 | None | 6 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 8 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
CHEMBL4209274 | 164164 | None | 6 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 8 | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
2950739 | 163058 | None | 6 | Human | Binding | pKi | = | 5.0 | 5.0 | -4 | 3 | ChEMBL | 351 | 9 | 1 | 4 | 4.6 | COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1 | 10.1016/j.ejmech.2018.04.010 | |||
CHEMBL4174845 | 163058 | None | 6 | Human | Binding | pKi | = | 5.0 | 5.0 | -4 | 3 | ChEMBL | 351 | 9 | 1 | 4 | 4.6 | COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1 | 10.1016/j.ejmech.2018.04.010 | |||
57403525 | 70178 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -691 | 10 | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
CHEMBL1940402 | 70178 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -691 | 10 | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
21533446 | 70179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -281 | 10 | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
CHEMBL1940403 | 70179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -281 | 10 | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
122483264 | 138179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 334 | 6 | 0 | 3 | 5.1 | O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3763534 | 138179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 334 | 6 | 0 | 3 | 5.1 | O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3765840 | 138179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 334 | 6 | 0 | 3 | 5.1 | O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 | 10.1016/j.ejmech.2016.01.043 | |||
71726944 | 102459 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | 1 | 3 | ChEMBL | 342 | 2 | 0 | 4 | 3.3 | CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1 | 10.1016/j.bmcl.2013.05.062 | |||
CHEMBL3039669 | 102459 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | 1 | 3 | ChEMBL | 342 | 2 | 0 | 4 | 3.3 | CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1 | 10.1016/j.bmcl.2013.05.062 | |||
CHEMBL3215698 | 102459 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | 1 | 3 | ChEMBL | 342 | 2 | 0 | 4 | 3.3 | CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1 | 10.1016/j.bmcl.2013.05.062 | |||
44388796 | 128127 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 415 | 5 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2005.05.059 | |||
CHEMBL366516 | 128127 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 415 | 5 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2005.05.059 | |||
11131952 | 49368 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 353 | 8 | 1 | 5 | 3.4 | O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O | 10.1021/jm020994z | |||
CHEMBL156385 | 49368 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 353 | 8 | 1 | 5 | 3.4 | O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O | 10.1021/jm020994z | |||
156016142 | 177853 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -5 | 5 | ChEMBL | 506 | 8 | 0 | 6 | 5.3 | O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.bmc.2020.115459 | |||
CHEMBL4642594 | 177853 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -5 | 5 | ChEMBL | 506 | 8 | 0 | 6 | 5.3 | O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.bmc.2020.115459 | |||
155554326 | 175052 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -13 | 5 | ChEMBL | 457 | 9 | 0 | 6 | 3.2 | COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmcl.2021.128028 | |||
CHEMBL4565558 | 175052 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -13 | 5 | ChEMBL | 457 | 9 | 0 | 6 | 3.2 | COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmcl.2021.128028 | |||
10638372 | 174490 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 306 | 4 | 0 | 2 | 3.0 | O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1 | 10.1021/jm8014553 | |||
CHEMBL455210 | 174490 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 306 | 4 | 0 | 2 | 3.0 | O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1 | 10.1021/jm8014553 | |||
145946265 | 167612 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -1 | 5 | ChEMBL | 396 | 10 | 0 | 4 | 3.9 | Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4203310 | 167612 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -1 | 5 | ChEMBL | 396 | 10 | 0 | 4 | 3.9 | Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1 | 10.1016/j.bmcl.2018.04.059 | |||
CHEMBL4299892 | 167612 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -1 | 5 | ChEMBL | 396 | 10 | 0 | 4 | 3.9 | Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1 | 10.1016/j.bmcl.2018.04.059 | |||
122483264 | 138179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 334 | 6 | 0 | 3 | 5.1 | O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3763534 | 138179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 334 | 6 | 0 | 3 | 5.1 | O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3765840 | 138179 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 334 | 6 | 0 | 3 | 5.1 | O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21 | 10.1016/j.ejmech.2016.01.043 | |||
155536533 | 172289 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -2 | 2 | ChEMBL | 444 | 7 | 1 | 5 | 4.8 | O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12 | 10.1016/j.ejmech.2019.111690 | |||
CHEMBL4473636 | 172289 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -2 | 2 | ChEMBL | 444 | 7 | 1 | 5 | 4.8 | O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12 | 10.1016/j.ejmech.2019.111690 | |||
155547693 | 173675 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -51 | 5 | ChEMBL | 314 | 4 | 1 | 7 | 1.1 | Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 | 10.1016/j.ejmech.2019.06.022 | |||
CHEMBL4532712 | 173675 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -51 | 5 | ChEMBL | 314 | 4 | 1 | 7 | 1.1 | Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 | 10.1016/j.ejmech.2019.06.022 | |||
164937988 | 195320 | None | 4 | Human | Binding | pKi | = | 7.0 | 7.0 | -23 | 21 | ChEMBL | 338 | 5 | 0 | 5 | 3.4 | c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1021/acs.jmedchem.3c00734 | |||
CHEMBL5400876 | 195320 | None | 4 | Human | Binding | pKi | = | 7.0 | 7.0 | -23 | 21 | ChEMBL | 338 | 5 | 0 | 5 | 3.4 | c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1021/acs.jmedchem.3c00734 | |||
90654683 | 110160 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 6 | 2 | ChEMBL | 452 | 8 | 1 | 4 | 2.9 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235755 | 110160 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 6 | 2 | ChEMBL | 452 | 8 | 1 | 4 | 2.9 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
44437860 | 91270 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -48 | 3 | ChEMBL | 411 | 6 | 0 | 4 | 3.2 | CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C | 10.1016/j.bmc.2007.07.029 | |||
CHEMBL240110 | 91270 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -48 | 3 | ChEMBL | 411 | 6 | 0 | 4 | 3.2 | CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C | 10.1016/j.bmc.2007.07.029 | |||
53325849 | 57025 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 322 | 3 | 1 | 2 | 4.5 | Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
CHEMBL1644269 | 57025 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 322 | 3 | 1 | 2 | 4.5 | Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1 | 10.1016/j.bmcl.2010.11.078 | |||
54758201 | 66014 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 451 | 6 | 1 | 3 | 5.7 | O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm200547z | |||
CHEMBL1836782 | 66014 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 451 | 6 | 1 | 3 | 5.7 | O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm200547z | |||
60165413 | 75386 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -31 | 7 | ChEMBL | 378 | 7 | 0 | 4 | 5.5 | O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | |||
CHEMBL2037531 | 75386 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -31 | 7 | ChEMBL | 378 | 7 | 0 | 4 | 5.5 | O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | |||
168288780 | 191557 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -63 | 5 | ChEMBL | 447 | 8 | 0 | 6 | 3.9 | O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12 | 10.1016/j.ejmech.2022.114319 | |||
CHEMBL5193103 | 191557 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -63 | 5 | ChEMBL | 447 | 8 | 0 | 6 | 3.9 | O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12 | 10.1016/j.ejmech.2022.114319 | |||
122483226 | 138193 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 4 | 3.8 | CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3763504 | 138193 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 4 | 3.8 | CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3765871 | 138193 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 4 | 3.8 | CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
122483226 | 138193 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 4 | 3.8 | CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3763504 | 138193 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 4 | 3.8 | CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
CHEMBL3765871 | 138193 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 4 | 3.8 | CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1 | 10.1016/j.ejmech.2016.01.043 | |||
90654703 | 110145 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 26 | 2 | ChEMBL | 399 | 7 | 1 | 6 | 1.6 | NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235740 | 110145 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 26 | 2 | ChEMBL | 399 | 7 | 1 | 6 | 1.6 | NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
134147935 | 149777 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 18 | 4 | ChEMBL | 487 | 10 | 1 | 6 | 3.6 | N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1 | 10.1016/j.ejmech.2016.05.005 | |||
CHEMBL3947670 | 149777 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 18 | 4 | ChEMBL | 487 | 10 | 1 | 6 | 3.6 | N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1 | 10.1016/j.ejmech.2016.05.005 | |||
154956306 | 179770 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | -12 | 6 | ChEMBL | 435 | 6 | 0 | 6 | 4.5 | Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O | 10.1016/j.ejmech.2020.112709 | |||
CHEMBL4743324 | 179770 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | -12 | 6 | ChEMBL | 435 | 6 | 0 | 6 | 4.5 | Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O | 10.1016/j.ejmech.2020.112709 | |||
90656690 | 111048 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 325 | 7 | 2 | 4 | 2.8 | OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262418 | 111048 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 325 | 7 | 2 | 4 | 2.8 | OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1 | 10.1016/j.ejmech.2014.04.034 | |||
118728522 | 117781 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -3 | 2 | ChEMBL | 390 | 8 | 0 | 5 | 3.4 | O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2015.02.042 | |||
CHEMBL3401485 | 117781 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -3 | 2 | ChEMBL | 390 | 8 | 0 | 5 | 3.4 | O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2015.02.042 | |||
164616670 | 184719 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -53 | 3 | ChEMBL | 424 | 7 | 1 | 7 | 3.8 | CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112529 | |||
CHEMBL4849077 | 184719 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -53 | 3 | ChEMBL | 424 | 7 | 1 | 7 | 3.8 | CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112529 | |||
11726532 | 97079 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | -141 | 4 | ChEMBL | 368 | 8 | 0 | 5 | 3.5 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020994z | |||
CHEMBL26677 | 97079 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | -141 | 4 | ChEMBL | 368 | 8 | 0 | 5 | 3.5 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020994z | |||
44460669 | 208061 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 283 | 4 | 0 | 3 | 2.9 | C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 | 10.1016/s0960-894x(02)00438-9 | |||
CHEMBL81576 | 208061 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 283 | 4 | 0 | 3 | 2.9 | C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1 | 10.1016/s0960-894x(02)00438-9 | |||
44460724 | 208078 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 339 | 4 | 0 | 4 | 4.0 | CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1 | 10.1016/s0960-894x(02)00438-9 | |||
CHEMBL81684 | 208078 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 339 | 4 | 0 | 4 | 4.0 | CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1 | 10.1016/s0960-894x(02)00438-9 | |||
168289915 | 191663 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -2 | 5 | ChEMBL | 553 | 11 | 4 | 8 | 4.9 | Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1 | 10.1016/j.ejmech.2021.113931 | |||
CHEMBL5194614 | 191663 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -2 | 5 | ChEMBL | 553 | 11 | 4 | 8 | 4.9 | Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1 | 10.1016/j.ejmech.2021.113931 | |||
60195992 | 81841 | None | 1 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 256 | 2 | 1 | 2 | 2.9 | Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1 | 10.1021/jm3003679 | |||
CHEMBL2164333 | 81841 | None | 1 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 256 | 2 | 1 | 2 | 2.9 | Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1 | 10.1021/jm3003679 | |||
10938620 | 206524 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 416 | 7 | 1 | 3 | 5.2 | COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 | 10.1021/jm0104264 | |||
CHEMBL70048 | 206524 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 416 | 7 | 1 | 3 | 5.2 | COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2 | 10.1021/jm0104264 | |||
155538236 | 172474 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 5 | ChEMBL | 496 | 7 | 1 | 5 | 5.2 | O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 | 10.1016/j.ejmech.2019.07.027 | |||
CHEMBL4476164 | 172474 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 5 | ChEMBL | 496 | 7 | 1 | 5 | 5.2 | O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2 | 10.1016/j.ejmech.2019.07.027 | |||
155515920 | 176789 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -109 | 4 | ChEMBL | 432 | 4 | 2 | 6 | 4.3 | COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12 | 10.1016/j.ejmech.2019.06.001 | |||
CHEMBL4442332 | 176789 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -109 | 4 | ChEMBL | 432 | 4 | 2 | 6 | 4.3 | COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12 | 10.1016/j.ejmech.2019.06.001 | |||
CHEMBL4598348 | 176789 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -109 | 4 | ChEMBL | 432 | 4 | 2 | 6 | 4.3 | COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12 | 10.1016/j.ejmech.2019.06.001 | |||
28 | 3496 | None | 35 | Human | Binding | pKi | = | 6.0 | 6.0 | -2137 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
3292447 | 3496 | None | 35 | Human | Binding | pKi | = | 6.0 | 6.0 | -2137 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
CHEMBL20963 | 3496 | None | 35 | Human | Binding | pKi | = | 6.0 | 6.0 | -2137 | 17 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
46203754 | 124612 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 | nan | |||
CHEMBL3640553 | 124612 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 | nan | |||
10024070 | 67210 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 402 | 8 | 0 | 4 | 3.5 | CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1 | 10.1021/jm049743b | |||
CHEMBL187764 | 67210 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 402 | 8 | 0 | 4 | 3.5 | CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1 | 10.1021/jm049743b | |||
46203754 | 124612 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 | nan | |||
CHEMBL3640553 | 124612 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1 | nan | |||
71458652 | 81466 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 4 | ChEMBL | 410 | 8 | 1 | 5 | 3.0 | CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159478 | 81466 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 4 | ChEMBL | 410 | 8 | 1 | 5 | 3.0 | CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1 | 10.1016/j.ejmech.2012.07.043 | |||
118731353 | 118176 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | 524 | 10 | 1 | 4 | 4.9 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3407516 | 118176 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | 524 | 10 | 1 | 4 | 4.9 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
145980458 | 166813 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 3 | ChEMBL | 476 | 6 | 2 | 5 | 2.9 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O | 10.1039/C8MD00168E | |||
CHEMBL4282860 | 166813 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 3 | ChEMBL | 476 | 6 | 2 | 5 | 2.9 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O | 10.1039/C8MD00168E | |||
155526720 | 171313 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 2 | ChEMBL | 437 | 6 | 1 | 3 | 5.9 | Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1 | 10.1016/j.bmcl.2019.126703 | |||
CHEMBL4459410 | 171313 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 2 | ChEMBL | 437 | 6 | 1 | 3 | 5.9 | Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1 | 10.1016/j.bmcl.2019.126703 | |||
155552707 | 174152 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 421 | 6 | 1 | 3 | 5.5 | Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1 | 10.1016/j.bmcl.2019.126703 | |||
CHEMBL4543789 | 174152 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 421 | 6 | 1 | 3 | 5.5 | Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1 | 10.1016/j.bmcl.2019.126703 | |||
2726 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
2726.0 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
621 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
83 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
DB00477 | 919 | None | 48 | Human | Binding | pKi | = | 8.0 | 8.0 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmc.2013.02.038 | |||
54758204 | 66016 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 6 | 2 | ChEMBL | 395 | 7 | 1 | 3 | 4.4 | CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
CHEMBL1836784 | 66016 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 6 | 2 | ChEMBL | 395 | 7 | 1 | 3 | 4.4 | CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21 | 10.1021/jm200547z | |||
11393666 | 193095 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -28 | 19 | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
CHEMBL5201983 | 193095 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -28 | 19 | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
CHEMBL5222597 | 193095 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -28 | 19 | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
42618267 | 182929 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 6 | 2 | ChEMBL | 398 | 7 | 1 | 4 | 4.0 | O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2009.02.008 | |||
CHEMBL479105 | 182929 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 6 | 2 | ChEMBL | 398 | 7 | 1 | 4 | 4.0 | O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2009.02.008 | |||
11683077 | 66023 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 414 | 6 | 1 | 2 | 5.7 | O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1 | 10.1021/jm200547z | |||
CHEMBL1836791 | 66023 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 414 | 6 | 1 | 2 | 5.7 | O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1 | 10.1021/jm200547z | |||
71061887 | 93171 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 66 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 | 10.1016/j.bmc.2014.01.016 | |||
CHEMBL2442996 | 93171 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 66 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 | 10.1016/j.bmc.2014.01.016 | |||
71061887 | 93171 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 66 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 | 10.1016/j.bmcl.2013.09.025 | |||
CHEMBL2442996 | 93171 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 66 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1 | 10.1016/j.bmcl.2013.09.025 | |||
44266284 | 97397 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 3 | 5.1 | Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL269400 | 97397 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 377 | 5 | 0 | 3 | 5.1 | Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
22273749 | 210646 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 363 | 4 | 0 | 3 | 4.7 | COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL9840 | 210646 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 363 | 4 | 0 | 3 | 4.7 | COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2020.115578 | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2020.115578 | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2020.115578 | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2020.115578 | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2020.115578 | |||
11191128 | 85244 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 421 | 8 | 2 | 4 | 4.3 | O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 | 10.1021/acs.jmedchem.5b00982 | |||
CHEMBL225512 | 85244 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 421 | 8 | 2 | 4 | 4.3 | O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 | 10.1021/acs.jmedchem.5b00982 | |||
11191128 | 85244 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 421 | 8 | 2 | 4 | 4.3 | O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 | 10.1021/jm049702f | |||
CHEMBL225512 | 85244 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 421 | 8 | 2 | 4 | 4.3 | O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21 | 10.1021/jm049702f | |||
134137732 | 147857 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 11 | 4 | ChEMBL | 485 | 11 | 1 | 4 | 5.9 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2016.05.005 | |||
CHEMBL3932551 | 147857 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 11 | 4 | ChEMBL | 485 | 11 | 1 | 4 | 5.9 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2016.05.005 | |||
179 | 400 | None | 72 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 50 | ChEMBL | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | 10.1016/j.bmcl.2021.128275 | |||
2159 | 400 | None | 72 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 50 | ChEMBL | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | 10.1016/j.bmcl.2021.128275 | |||
2159.0 | 400 | None | 72 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 50 | ChEMBL | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | 10.1016/j.bmcl.2021.128275 | |||
963 | 400 | None | 72 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 50 | ChEMBL | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | 10.1016/j.bmcl.2021.128275 | |||
CHEMBL243712 | 400 | None | 72 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 50 | ChEMBL | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | 10.1016/j.bmcl.2021.128275 | |||
DB06288 | 400 | None | 72 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 50 | ChEMBL | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | 10.1016/j.bmcl.2021.128275 | |||
90656711 | 111031 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 371 | 4 | 2 | 3 | 4.4 | Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262393 | 111031 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 371 | 4 | 2 | 3 | 4.4 | Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 | 10.1016/j.ejmech.2014.04.034 | |||
90656711 | 111031 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 371 | 4 | 2 | 3 | 4.4 | Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262393 | 111031 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 371 | 4 | 2 | 3 | 4.4 | Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1 | 10.1016/j.ejmech.2014.04.034 | |||
118713683 | 114452 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 2 | ChEMBL | 409 | 9 | 0 | 6 | 4.0 | COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL3331386 | 114452 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -9 | 2 | ChEMBL | 409 | 9 | 0 | 6 | 4.0 | COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
44266245 | 167313 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 6 | 2 | ChEMBL | 398 | 5 | 0 | 3 | 4.3 | O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
CHEMBL429202 | 167313 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 6 | 2 | ChEMBL | 398 | 5 | 0 | 3 | 4.3 | O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(03)00077-5 | |||
136180320 | 117778 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 410 | 7 | 1 | 4 | 4.1 | O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12 | 10.1016/j.bmcl.2015.02.042 | |||
CHEMBL3401482 | 117778 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 410 | 7 | 1 | 4 | 4.1 | O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12 | 10.1016/j.bmcl.2015.02.042 | |||
164622487 | 186228 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 339 | 4 | 0 | 4 | 2.8 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | |||
CHEMBL4871850 | 186228 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 339 | 4 | 0 | 4 | 2.8 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | |||
2470 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
3300 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
5265 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
99 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
CHEMBL267930 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
CHEMBL5071978 | 216760 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 6 | ChEMBL | None | None | None | CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
145976686 | 164017 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 24 | 2 | ChEMBL | 564 | 7 | 1 | 4 | 3.9 | O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00828 | |||
CHEMBL4207365 | 164017 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 24 | 2 | ChEMBL | 564 | 7 | 1 | 4 | 3.9 | O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00828 | |||
56944861 | 157166 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -42 | 4 | ChEMBL | 493 | 8 | 2 | 3 | 5.8 | O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL4074195 | 157166 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -42 | 4 | ChEMBL | 493 | 8 | 2 | 3 | 5.8 | O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 | 10.1021/acs.jmedchem.7b00839 | |||
2470 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
3300 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
5265 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
99 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
CHEMBL267930 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm030030n | |||
2470 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | |||
3300 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | |||
5265 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | |||
99 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL267930 | 3653 | None | 40 | Human | Binding | pKi | = | 7.0 | 7.0 | -1258 | 59 | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | |||
11207101 | 75971 | None | 0 | Rat | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 236 | 4 | 0 | 4 | 1.5 | COc1ccc2c(c1)N(CCN(C)C)CCO2 | 10.1021/jm049743b | |||
CHEMBL2051975 | 75971 | None | 0 | Rat | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 236 | 4 | 0 | 4 | 1.5 | COc1ccc2c(c1)N(CCN(C)C)CCO2 | 10.1021/jm049743b | |||
9818448 | 127547 | None | 2 | Rat | Binding | pKi | = | 6.0 | 6.0 | -17 | 3 | ChEMBL | 318 | 4 | 1 | 2 | 4.5 | COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1 | 10.1021/jm049743b | |||
CHEMBL366081 | 127547 | None | 2 | Rat | Binding | pKi | = | 6.0 | 6.0 | -17 | 3 | ChEMBL | 318 | 4 | 1 | 2 | 4.5 | COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1 | 10.1021/jm049743b | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
198914 | 146791 | None | 6 | Human | Binding | pKi | = | 6.0 | 6.0 | 79 | 2 | ChEMBL | 264 | 1 | 3 | 2 | 3.1 | Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1 | 10.1016/j.bmcl.2007.01.093 | |||
CHEMBL392401 | 146791 | None | 6 | Human | Binding | pKi | = | 6.0 | 6.0 | 79 | 2 | ChEMBL | 264 | 1 | 3 | 2 | 3.1 | Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1 | 10.1016/j.bmcl.2007.01.093 | |||
5048 | 3133 | None | 50 | Human | Binding | pKi | = | 6.0 | 6.0 | -537 | 10 | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.6019/CHEMBL5442175 | |||
8924 | 3133 | None | 50 | Human | Binding | pKi | = | 6.0 | 6.0 | -537 | 10 | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.6019/CHEMBL5442175 | |||
9948102 | 3133 | None | 50 | Human | Binding | pKi | = | 6.0 | 6.0 | -537 | 10 | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.6019/CHEMBL5442175 | |||
9948102.0 | 3133 | None | 50 | Human | Binding | pKi | = | 6.0 | 6.0 | -537 | 10 | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.6019/CHEMBL5442175 | |||
CHEMBL462605 | 3133 | None | 50 | Human | Binding | pKi | = | 6.0 | 6.0 | -537 | 10 | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.6019/CHEMBL5442175 | |||
DB11642 | 3133 | None | 50 | Human | Binding | pKi | = | 6.0 | 6.0 | -537 | 10 | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.6019/CHEMBL5442175 | |||
71460455 | 81397 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 430 | 9 | 1 | 4 | 4.6 | CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159314 | 81397 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 430 | 9 | 1 | 4 | 4.6 | CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1 | 10.1016/j.ejmech.2012.07.043 | |||
71462156 | 81402 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 445 | 6 | 1 | 4 | 5.1 | O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159319 | 81402 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 445 | 6 | 1 | 4 | 5.1 | O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1 | 10.1016/j.ejmech.2012.07.043 | |||
2435 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
2435.0 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
395 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
520 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
5386 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
CHEMBL844 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
DB00484 | 722 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -186 | 13 | ChEMBL | 291 | 1 | 2 | 5 | 1.8 | Brc1c(ccc2c1nccn2)NC1=NCCN1 | 10.6019/CHEMBL5442175 | |||
90654673 | 110150 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -54 | 2 | ChEMBL | 494 | 10 | 1 | 5 | 3.9 | CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235745 | 110150 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -54 | 2 | ChEMBL | 494 | 10 | 1 | 5 | 3.9 | CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
11154555 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
11154555.0 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
5037 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
7671 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
CHEMBL2028019 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
CHEMBL3085826 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
DB06016 | 800 | None | 50 | Human | Binding | pKi | = | 7.0 | 7.0 | -138 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2019.111736 | |||
118736376 | 119012 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -5 | 4 | ChEMBL | 531 | 7 | 0 | 9 | 3.3 | Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.ejmech.2015.04.046 | |||
CHEMBL3423340 | 119012 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -5 | 4 | ChEMBL | 531 | 7 | 0 | 9 | 3.3 | Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.ejmech.2015.04.046 | |||
127052487 | 140887 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -6 | 6 | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL3818805 | 140887 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -6 | 6 | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | |||
90656681 | 111043 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 327 | 6 | 0 | 3 | 3.5 | CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262413 | 111043 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 327 | 6 | 0 | 3 | 3.5 | CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1 | 10.1016/j.ejmech.2014.04.034 | |||
2146 | 3100 | None | 45 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 11 | ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNC[C@@H](c1cccc(c1)O)O | 10.6019/CHEMBL5442175 | |||
485 | 3100 | None | 45 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 11 | ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNC[C@@H](c1cccc(c1)O)O | 10.6019/CHEMBL5442175 | |||
6041 | 3100 | None | 45 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 11 | ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNC[C@@H](c1cccc(c1)O)O | 10.6019/CHEMBL5442175 | |||
6041.0 | 3100 | None | 45 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 11 | ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNC[C@@H](c1cccc(c1)O)O | 10.6019/CHEMBL5442175 | |||
CHEMBL1215 | 3100 | None | 45 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 11 | ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNC[C@@H](c1cccc(c1)O)O | 10.6019/CHEMBL5442175 | |||
DB00388 | 3100 | None | 45 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 11 | ChEMBL | 167 | 3 | 3 | 3 | 0.6 | CNC[C@@H](c1cccc(c1)O)O | 10.6019/CHEMBL5442175 | |||
155561995 | 175826 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -36 | 5 | ChEMBL | 532 | 7 | 1 | 5 | 5.4 | O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2 | 10.1016/j.ejmech.2019.07.027 | |||
CHEMBL4582567 | 175826 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -36 | 5 | ChEMBL | 532 | 7 | 1 | 5 | 5.4 | O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2 | 10.1016/j.ejmech.2019.07.027 | |||
155522218 | 170740 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -51 | 5 | ChEMBL | 492 | 7 | 1 | 5 | 5.3 | O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1 | 10.1016/j.ejmech.2019.01.031 | |||
CHEMBL4451231 | 170740 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -51 | 5 | ChEMBL | 492 | 7 | 1 | 5 | 5.3 | O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1 | 10.1016/j.ejmech.2019.01.031 | |||
145983018 | 165612 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 5 | ChEMBL | 507 | 6 | 1 | 7 | 3.0 | O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4240910 | 165612 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 5 | ChEMBL | 507 | 6 | 1 | 7 | 3.0 | O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1 | 10.1016/j.ejmech.2018.01.002 | |||
46204083 | 124618 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 1 | 3 | 4.4 | COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 | nan | |||
CHEMBL3640559 | 124618 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 1 | 3 | 4.4 | COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 | nan | |||
46204083 | 124618 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 1 | 3 | 4.4 | COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 | nan | |||
CHEMBL3640559 | 124618 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 1 | 3 | 4.4 | COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1 | nan | |||
118724648 | 116529 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -5 | 3 | ChEMBL | 515 | 7 | 0 | 10 | 1.5 | Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
CHEMBL3361005 | 116529 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -5 | 3 | ChEMBL | 515 | 7 | 0 | 10 | 1.5 | Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
127052487 | 140887 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -6 | 6 | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL3818805 | 140887 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -6 | 6 | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | |||
49756 | 206770 | None | 10 | Rat | Binding | pKi | = | 6.0 | 6.0 | -14 | 8 | ChEMBL | 232 | 4 | 1 | 2 | 2.6 | COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 | 10.1021/jm030826m | |||
CHEMBL7143 | 206770 | None | 10 | Rat | Binding | pKi | = | 6.0 | 6.0 | -14 | 8 | ChEMBL | 232 | 4 | 1 | 2 | 2.6 | COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 | 10.1021/jm030826m | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 6.0 | 6.0 | -263 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2016.06.011 | |||
134154108 | 152709 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 309 | 4 | 0 | 2 | 4.9 | COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C | 10.1016/j.ejmech.2016.07.029 | |||
CHEMBL3972166 | 152709 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 309 | 4 | 0 | 2 | 4.9 | COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C | 10.1016/j.ejmech.2016.07.029 | |||
90654701 | 110143 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 426 | 7 | 1 | 4 | 2.8 | NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235738 | 110143 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 426 | 7 | 1 | 4 | 2.8 | NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
57398619 | 71590 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 7 | 3 | ChEMBL | 444 | 7 | 1 | 5 | 3.4 | O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 | 10.1016/j.bmc.2011.12.039 | |||
CHEMBL1949962 | 71590 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 7 | 3 | ChEMBL | 444 | 7 | 1 | 5 | 3.4 | O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 | 10.1016/j.bmc.2011.12.039 | |||
CHEMBL1963099 | 71590 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 7 | 3 | ChEMBL | 444 | 7 | 1 | 5 | 3.4 | O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12 | 10.1016/j.bmc.2011.12.039 | |||
136180318 | 117776 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 2 | ChEMBL | 396 | 6 | 1 | 4 | 3.7 | O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 | 10.1016/j.bmcl.2015.02.042 | |||
CHEMBL3401480 | 117776 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -14 | 2 | ChEMBL | 396 | 6 | 1 | 4 | 3.7 | O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12 | 10.1016/j.bmcl.2015.02.042 | |||
46204089 | 124625 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 | nan | |||
CHEMBL3640565 | 124625 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 | nan | |||
46204089 | 124625 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 | nan | |||
CHEMBL3640565 | 124625 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1 | nan | |||
44286416 | 141505 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -11 | 5 | ChEMBL | 448 | 8 | 0 | 6 | 4.3 | O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.bmc.2020.115459 | |||
CHEMBL38409 | 141505 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -11 | 5 | ChEMBL | 448 | 8 | 0 | 6 | 4.3 | O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.bmc.2020.115459 | |||
156014787 | 177650 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 3 | 4 | ChEMBL | 428 | 6 | 1 | 5 | 3.6 | COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 | 10.1016/j.bmc.2020.115578 | |||
CHEMBL4640281 | 177650 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 3 | 4 | ChEMBL | 428 | 6 | 1 | 5 | 3.6 | COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2 | 10.1016/j.bmc.2020.115578 | |||
15443 | 117874 | None | 64 | Human | Binding | pKi | = | 6.9 | 6.9 | -17 | 9 | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113243 | |||
CHEMBL340211 | 117874 | None | 64 | Human | Binding | pKi | = | 6.9 | 6.9 | -17 | 9 | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113243 | |||
15443 | 117874 | None | 64 | Human | Binding | pKi | = | 6.9 | 6.9 | -17 | 9 | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | |||
CHEMBL340211 | 117874 | None | 64 | Human | Binding | pKi | = | 6.9 | 6.9 | -17 | 9 | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | |||
162673483 | 183878 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 396 | 8 | 2 | 5 | 2.3 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1 | 10.1016/j.ejmech.2020.112437 | |||
CHEMBL4796251 | 183878 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 396 | 8 | 2 | 5 | 2.3 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1 | 10.1016/j.ejmech.2020.112437 | |||
CHEMBL4803945 | 183878 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 396 | 8 | 2 | 5 | 2.3 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1 | 10.1016/j.ejmech.2020.112437 | |||
71458622 | 81389 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 376 | 7 | 1 | 5 | 3.7 | CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159306 | 81389 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 376 | 7 | 1 | 5 | 3.7 | CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1 | 10.1016/j.ejmech.2012.07.043 | |||
71727068 | 91301 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 4 | ChEMBL | 430 | 5 | 0 | 6 | 4.3 | COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1 | 10.1016/j.bmcl.2013.05.062 | |||
CHEMBL2401934 | 91301 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 4 | ChEMBL | 430 | 5 | 0 | 6 | 4.3 | COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1 | 10.1016/j.bmcl.2013.05.062 | |||
CHEMBL2401938 | 91301 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 4 | ChEMBL | 430 | 5 | 0 | 6 | 4.3 | COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1 | 10.1016/j.bmcl.2013.05.062 | |||
155510928 | 176574 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -575 | 4 | ChEMBL | 368 | 4 | 2 | 6 | 2.9 | COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2019.06.001 | |||
CHEMBL4435010 | 176574 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -575 | 4 | ChEMBL | 368 | 4 | 2 | 6 | 2.9 | COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2019.06.001 | |||
CHEMBL4596543 | 176574 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -575 | 4 | ChEMBL | 368 | 4 | 2 | 6 | 2.9 | COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1 | 10.1016/j.ejmech.2019.06.001 | |||
13069623 | 120673 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -50 | 4 | ChEMBL | 396 | 6 | 0 | 8 | 1.0 | Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
CHEMBL3360994 | 120673 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -50 | 4 | ChEMBL | 396 | 6 | 0 | 8 | 1.0 | Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
CHEMBL3546108 | 120673 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -50 | 4 | ChEMBL | 396 | 6 | 0 | 8 | 1.0 | Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O | 10.1016/j.bmc.2014.11.008 | |||
44456400 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
CHEMBL1188501 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
CHEMBL2436555 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
CHEMBL536539 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
10317139 | 67097 | None | 0 | Rat | Binding | pKi | = | 4.9 | 4.9 | -758 | 2 | ChEMBL | 371 | 4 | 0 | 5 | 2.3 | COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1 | 10.1016/j.bmcl.2004.09.029 | |||
CHEMBL187270 | 67097 | None | 0 | Rat | Binding | pKi | = | 4.9 | 4.9 | -758 | 2 | ChEMBL | 371 | 4 | 0 | 5 | 2.3 | COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1 | 10.1016/j.bmcl.2004.09.029 | |||
145973438 | 164618 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | 2 | 2 | ChEMBL | 394 | 7 | 1 | 4 | 3.2 | O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.8b00828 | |||
CHEMBL4214853 | 164618 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | 2 | 2 | ChEMBL | 394 | 7 | 1 | 4 | 3.2 | O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.8b00828 | |||
145971588 | 164648 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | 438 | 7 | 1 | 4 | 3.3 | O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00828 | |||
CHEMBL4215182 | 164648 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | 438 | 7 | 1 | 4 | 3.3 | O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00828 | |||
155539483 | 172965 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -162 | 5 | ChEMBL | 504 | 7 | 2 | 3 | 5.4 | O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 | 10.1016/j.ejmech.2019.111736 | |||
CHEMBL4515160 | 172965 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -162 | 5 | ChEMBL | 504 | 7 | 2 | 3 | 5.4 | O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 | 10.1016/j.ejmech.2019.111736 | |||
44456400 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
CHEMBL1188501 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
CHEMBL2436555 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
CHEMBL536539 | 12838 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 10 | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | |||
122181336 | 121944 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -8 | 3 | ChEMBL | 432 | 6 | 1 | 4 | 3.4 | O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2015.04.026 | |||
CHEMBL3590088 | 121944 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -8 | 3 | ChEMBL | 432 | 6 | 1 | 4 | 3.4 | O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2015.04.026 | |||
118731347 | 118248 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | 428 | 10 | 1 | 4 | 3.4 | CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409031 | 118248 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | 428 | 10 | 1 | 4 | 3.4 | CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
44455426 | 155239 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -1 | 12 | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
CHEMBL402143 | 155239 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -1 | 12 | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
72198191 | 89854 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -144 | 4 | ChEMBL | 458 | 5 | 2 | 3 | 4.5 | O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 | 10.1016/j.ejmech.2013.02.033 | |||
CHEMBL2377445 | 89854 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -144 | 4 | ChEMBL | 458 | 5 | 2 | 3 | 4.5 | O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1 | 10.1016/j.ejmech.2013.02.033 | |||
46205373 | 124654 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 321 | 3 | 1 | 2 | 4.5 | COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 | nan | |||
CHEMBL3640593 | 124654 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 321 | 3 | 1 | 2 | 4.5 | COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 | nan | |||
46205373 | 124654 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 321 | 3 | 1 | 2 | 4.5 | COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 | nan | |||
CHEMBL3640593 | 124654 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 321 | 3 | 1 | 2 | 4.5 | COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1 | nan | |||
122181339 | 121947 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -22 | 3 | ChEMBL | 500 | 6 | 1 | 4 | 4.4 | O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2015.04.026 | |||
CHEMBL3590091 | 121947 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -22 | 3 | ChEMBL | 500 | 6 | 1 | 4 | 4.4 | O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2015.04.026 | |||
156013203 | 177587 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 5 | ChEMBL | 477 | 8 | 0 | 4 | 4.7 | O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmc.2020.115459 | |||
CHEMBL4639203 | 177587 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 5 | ChEMBL | 477 | 8 | 0 | 4 | 4.7 | O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmc.2020.115459 | |||
156021656 | 178292 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 269 | 2 | 0 | 1 | 3.9 | CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1 | 10.1016/j.bmc.2019.115262 | |||
CHEMBL4649308 | 178292 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 269 | 2 | 0 | 1 | 3.9 | CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1 | 10.1016/j.bmc.2019.115262 | |||
162647097 | 179825 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -125 | 4 | ChEMBL | 465 | 8 | 1 | 6 | 4.0 | COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 | 10.1016/j.ejmech.2020.112149 | |||
CHEMBL4744007 | 179825 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -125 | 4 | ChEMBL | 465 | 8 | 1 | 6 | 4.0 | COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1 | 10.1016/j.ejmech.2020.112149 | |||
156020908 | 178136 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -2 | 5 | ChEMBL | 498 | 8 | 0 | 6 | 5.4 | O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.bmc.2020.115459 | |||
CHEMBL4646868 | 178136 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -2 | 5 | ChEMBL | 498 | 8 | 0 | 6 | 5.4 | O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.bmc.2020.115459 | |||
54758298 | 66029 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -4 | 3 | ChEMBL | 401 | 6 | 1 | 3 | 4.5 | O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
CHEMBL1836857 | 66029 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -4 | 3 | ChEMBL | 401 | 6 | 1 | 3 | 4.5 | O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2014.08.023 | |||
11207101 | 75971 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 236 | 4 | 0 | 4 | 1.5 | COc1ccc2c(c1)N(CCN(C)C)CCO2 | 10.1021/jm049743b | |||
CHEMBL2051975 | 75971 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 236 | 4 | 0 | 4 | 1.5 | COc1ccc2c(c1)N(CCN(C)C)CCO2 | 10.1021/jm049743b | |||
44263956 | 206906 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 232 | 4 | 0 | 3 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)cn2C | 10.1021/jm049743b | |||
CHEMBL7220 | 206906 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 232 | 4 | 0 | 3 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)cn2C | 10.1021/jm049743b | |||
90654700 | 110142 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 390 | 8 | 1 | 4 | 2.0 | NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235737 | 110142 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 390 | 8 | 1 | 4 | 2.0 | NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
71454899 | 81191 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 428 | 10 | 1 | 5 | 4.3 | CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2158026 | 81191 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 428 | 10 | 1 | 5 | 4.3 | CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1 | 10.1016/j.ejmech.2012.07.043 | |||
155526651 | 171277 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -5 | 5 | ChEMBL | 464 | 8 | 0 | 4 | 5.7 | O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1 | 10.1016/j.bmcl.2019.06.029 | |||
CHEMBL4458938 | 171277 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -5 | 5 | ChEMBL | 464 | 8 | 0 | 4 | 5.7 | O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1 | 10.1016/j.bmcl.2019.06.029 | |||
155540823 | 172643 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | 456 | 7 | 0 | 5 | 3.6 | CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2016.06.080 | |||
CHEMBL4483779 | 172643 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | 456 | 7 | 0 | 5 | 3.6 | CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2016.06.080 | |||
2726 | 919 | None | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | |||
2726.0 | 919 | None | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | |||
621 | 919 | None | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | |||
83 | 919 | None | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | |||
DB00477 | 919 | None | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -13 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | |||
11409589 | 85164 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 435 | 9 | 1 | 4 | 4.6 | COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 | 10.1021/jm049702f | |||
CHEMBL224883 | 85164 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 435 | 9 | 1 | 4 | 4.6 | COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1 | 10.1021/jm049702f | |||
127029649 | 138259 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | 5 | 3 | ChEMBL | 462 | 6 | 2 | 5 | 2.1 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
CHEMBL3769536 | 138259 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | 5 | 3 | ChEMBL | 462 | 6 | 2 | 5 | 2.1 | CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O | 10.1016/j.ejmech.2016.02.024 | |||
126720403 | 162705 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -933 | 5 | ChEMBL | 353 | 4 | 1 | 5 | 3.2 | CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1 | 10.1016/j.ejmech.2017.12.053 | |||
CHEMBL4169236 | 162705 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -933 | 5 | ChEMBL | 353 | 4 | 1 | 5 | 3.2 | CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1 | 10.1016/j.ejmech.2017.12.053 | |||
155542321 | 173228 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -1096 | 5 | ChEMBL | 356 | 5 | 1 | 7 | 2.2 | Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 | 10.1016/j.ejmech.2019.06.022 | |||
CHEMBL4520796 | 173228 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -1096 | 5 | ChEMBL | 356 | 5 | 1 | 7 | 2.2 | Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 | 10.1016/j.ejmech.2019.06.022 | |||
155542321 | 173228 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -1096 | 5 | ChEMBL | 356 | 5 | 1 | 7 | 2.2 | Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 | 10.1016/j.ejmech.2022.114645 | |||
CHEMBL4520796 | 173228 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -1096 | 5 | ChEMBL | 356 | 5 | 1 | 7 | 2.2 | Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1 | 10.1016/j.ejmech.2022.114645 | |||
90654685 | 110162 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -5 | 2 | ChEMBL | 522 | 5 | 1 | 4 | 4.4 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235757 | 110162 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -5 | 2 | ChEMBL | 522 | 5 | 1 | 4 | 4.4 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.ejmech.2014.03.005 | |||
162670959 | 183860 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 | 10.1016/j.ejmech.2020.112437 | |||
CHEMBL4791316 | 183860 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 | 10.1016/j.ejmech.2020.112437 | |||
CHEMBL4803791 | 183860 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 2 | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1 | 10.1016/j.ejmech.2020.112437 | |||
90654694 | 110136 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -27 | 2 | ChEMBL | 402 | 9 | 1 | 5 | 1.9 | COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
CHEMBL3235731 | 110136 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -27 | 2 | ChEMBL | 402 | 9 | 1 | 5 | 1.9 | COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 | 10.1016/j.ejmech.2014.03.005 | |||
10947658 | 28710 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -10 | 16 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
CHEMBL137781 | 28710 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -10 | 16 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
46214153 | 110758 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 3 | 5 | ChEMBL | 367 | 5 | 1 | 3 | 4.0 | Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1 | 10.1021/ml500082j | |||
CHEMBL3260334 | 110758 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 3 | 5 | ChEMBL | 367 | 5 | 1 | 3 | 4.0 | Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1 | 10.1021/ml500082j | |||
44374299 | 119601 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 17 | 3 | ChEMBL | 264 | 5 | 0 | 4 | 3.5 | CN(C)CCSc1nc(-c2ccccc2)cs1 | 10.1016/j.bmcl.2003.11.050 | |||
CHEMBL345803 | 119601 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 17 | 3 | ChEMBL | 264 | 5 | 0 | 4 | 3.5 | CN(C)CCSc1nc(-c2ccccc2)cs1 | 10.1016/j.bmcl.2003.11.050 | |||
11603514 | 71514 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | |||
CHEMBL1926760 | 71514 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | |||
CHEMBL1962492 | 71514 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 1 | 4 | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | |||
127026450 | 137844 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 10 | 2 | ChEMBL | 480 | 8 | 1 | 4 | 4.8 | O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1 | 10.1016/j.ejmech.2015.11.040 | |||
CHEMBL3759281 | 137844 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 10 | 2 | ChEMBL | 480 | 8 | 1 | 4 | 4.8 | O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1 | 10.1016/j.ejmech.2015.11.040 | |||
145985233 | 165618 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 5 | ChEMBL | 508 | 6 | 0 | 6 | 4.9 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4241050 | 165618 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 5 | ChEMBL | 508 | 6 | 0 | 6 | 4.9 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
145984737 | 165674 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -23 | 5 | ChEMBL | 507 | 6 | 0 | 7 | 4.2 | O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4242392 | 165674 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -23 | 5 | ChEMBL | 507 | 6 | 0 | 7 | 4.2 | O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
145985527 | 165804 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 5 | ChEMBL | 520 | 6 | 1 | 4 | 5.7 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4245622 | 165804 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 5 | ChEMBL | 520 | 6 | 1 | 4 | 5.7 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
145985823 | 166019 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 5 | ChEMBL | 508 | 6 | 0 | 6 | 4.9 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
CHEMBL4250475 | 166019 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 5 | ChEMBL | 508 | 6 | 0 | 6 | 4.9 | O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1 | 10.1016/j.ejmech.2018.01.002 | |||
134153716 | 152573 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 9 | 4 | ChEMBL | 510 | 11 | 1 | 5 | 5.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1 | 10.1016/j.ejmech.2016.05.005 | |||
CHEMBL3971125 | 152573 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 9 | 4 | ChEMBL | 510 | 11 | 1 | 5 | 5.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1 | 10.1016/j.ejmech.2016.05.005 | |||
71453252 | 81392 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 15 | 2 | ChEMBL | 476 | 8 | 1 | 5 | 4.9 | O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159309 | 81392 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 15 | 2 | ChEMBL | 476 | 8 | 1 | 5 | 4.9 | O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 | 10.1016/j.ejmech.2012.07.043 | |||
71453282 | 81479 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 4 | ChEMBL | 462 | 8 | 1 | 5 | 4.5 | O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1 | 10.1016/j.ejmech.2012.07.043 | |||
CHEMBL2159491 | 81479 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 4 | ChEMBL | 462 | 8 | 1 | 5 | 4.5 | O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1 | 10.1016/j.ejmech.2012.07.043 | |||
71574210 | 86317 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 5 | ChEMBL | 478 | 7 | 1 | 5 | 4.0 | O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
CHEMBL2312934 | 86317 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 5 | ChEMBL | 478 | 7 | 1 | 5 | 4.0 | O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1 | 10.1016/j.ejmech.2012.11.042 | |||
118731351 | 118252 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 4 | ChEMBL | 496 | 8 | 1 | 4 | 4.1 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409035 | 118252 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 4 | ChEMBL | 496 | 8 | 1 | 4 | 4.1 | NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.041 | |||
118731365 | 118265 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 2 | ChEMBL | 592 | 10 | 0 | 4 | 6.4 | O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
CHEMBL3409048 | 118265 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 2 | ChEMBL | 592 | 10 | 0 | 4 | 6.4 | O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1 | 10.1016/j.ejmech.2014.12.041 | |||
145947977 | 167817 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 48 | 3 | ChEMBL | 433 | 6 | 2 | 6 | 1.5 | CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O | 10.1016/j.ejmech.2018.01.093 | |||
CHEMBL4162279 | 167817 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 48 | 3 | ChEMBL | 433 | 6 | 2 | 6 | 1.5 | CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O | 10.1016/j.ejmech.2018.01.093 | |||
CHEMBL4302540 | 167817 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 48 | 3 | ChEMBL | 433 | 6 | 2 | 6 | 1.5 | CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O | 10.1016/j.ejmech.2018.01.093 | |||
23642275 | 482 | None | 26 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.bmc.2019.115262 | |||
8433 | 482 | None | 26 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.bmc.2019.115262 | |||
CHEMBL2164327 | 482 | None | 26 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 8 | ChEMBL | 283 | 2 | 0 | 3 | 3.1 | CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C | 10.1016/j.bmc.2019.115262 | |||
71453252 | 81392 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 15 | 2 | ChEMBL | 476 | 8 | 1 | 5 | 4.9 | O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 | 10.1039/C5MD00166H | |||
CHEMBL2159309 | 81392 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 15 | 2 | ChEMBL | 476 | 8 | 1 | 5 | 4.9 | O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1 | 10.1039/C5MD00166H | |||
142601335 | 186527 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 44 | 7 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876193 | 186527 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 44 | 7 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
66803497 | 158603 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -2 | 4 | ChEMBL | 463 | 7 | 2 | 3 | 4.9 | O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL4091193 | 158603 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -2 | 4 | ChEMBL | 463 | 7 | 2 | 3 | 4.9 | O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 | 10.1021/acs.jmedchem.7b00839 | |||
145964944 | 164176 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -14 | 2 | ChEMBL | 391 | 4 | 0 | 4 | 5.0 | Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl | 10.1016/j.bmcl.2017.11.007 | |||
CHEMBL4209430 | 164176 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -14 | 2 | ChEMBL | 391 | 4 | 0 | 4 | 5.0 | Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl | 10.1016/j.bmcl.2017.11.007 | |||
10862787 | 103092 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 6 | 1 | 3 | 4.9 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 | 10.1016/j.bmc.2019.06.028 | |||
CHEMBL307101 | 103092 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 6 | 1 | 3 | 4.9 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 | 10.1016/j.bmc.2019.06.028 | |||
90656696 | 111061 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 367 | 9 | 1 | 4 | 4.2 | CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262430 | 111061 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 367 | 9 | 1 | 4 | 4.2 | CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 | 10.1016/j.ejmech.2014.04.034 | |||
44374299 | 119601 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 17 | 3 | ChEMBL | 264 | 5 | 0 | 4 | 3.5 | CN(C)CCSc1nc(-c2ccccc2)cs1 | 10.1016/j.bmc.2010.01.035 | |||
CHEMBL345803 | 119601 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 17 | 3 | ChEMBL | 264 | 5 | 0 | 4 | 3.5 | CN(C)CCSc1nc(-c2ccccc2)cs1 | 10.1016/j.bmc.2010.01.035 | |||
127051844 | 140934 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 9 | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL3819427 | 140934 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 9 | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
145988193 | 167175 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 5 | 2 | ChEMBL | 449 | 6 | 1 | 2 | 6.0 | Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
CHEMBL4289605 | 167175 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 5 | 2 | ChEMBL | 449 | 6 | 1 | 2 | 6.0 | Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1016/j.ejmech.2017.12.063 | |||
90656672 | 111055 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 451 | 8 | 1 | 5 | 3.8 | O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262425 | 111055 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 451 | 8 | 1 | 5 | 3.8 | O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1 | 10.1016/j.ejmech.2014.04.034 | |||
155565215 | 175714 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 10 | 2 | ChEMBL | 433 | 6 | 1 | 7 | 3.5 | Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O | 10.1016/j.ejmech.2019.111690 | |||
CHEMBL4580230 | 175714 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 10 | 2 | ChEMBL | 433 | 6 | 1 | 7 | 3.5 | Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O | 10.1016/j.ejmech.2019.111690 | |||
10862787 | 103092 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 6 | 1 | 3 | 4.9 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 | 10.1021/jm0104264 | |||
CHEMBL307101 | 103092 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 6 | 1 | 3 | 4.9 | O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3 | 10.1021/jm0104264 | |||
11826723 | 206701 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 464 | 6 | 1 | 2 | 5.9 | O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 | 10.1021/jm0104264 | |||
CHEMBL71057 | 206701 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 464 | 6 | 1 | 2 | 5.9 | O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3 | 10.1021/jm0104264 | |||
142601335 | 186527 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 44 | 7 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
CHEMBL4876193 | 186527 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 44 | 7 | ChEMBL | 256 | 2 | 2 | 3 | 2.2 | Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1 | 10.1021/acs.jmedchem.1c01093 | |||
127051844 | 140934 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 9 | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
CHEMBL3819427 | 140934 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 9 | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | |||
72734860 | 104012 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 5 | ChEMBL | 251 | 1 | 2 | 1 | 1.7 | NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2 | 10.1016/j.bmc.2013.10.010 | |||
CHEMBL3092753 | 104012 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 5 | ChEMBL | 251 | 1 | 2 | 1 | 1.7 | NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2 | 10.1016/j.bmc.2013.10.010 | |||
44456395 | 95724 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 5 | ChEMBL | 225 | 1 | 2 | 4 | 2.0 | COc1c(Cl)ccc2c1C(C)NC(N)=N2 | 10.1016/j.bmcl.2007.10.080 | |||
CHEMBL258073 | 95724 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 5 | ChEMBL | 225 | 1 | 2 | 4 | 2.0 | COc1c(Cl)ccc2c1C(C)NC(N)=N2 | 10.1016/j.bmcl.2007.10.080 | |||
11302161 | 67299 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | -8 | 2 | ChEMBL | 337 | 7 | 0 | 2 | 5.3 | CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1 | 10.1021/jm0498102 | |||
CHEMBL188176 | 67299 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | -8 | 2 | ChEMBL | 337 | 7 | 0 | 2 | 5.3 | CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1 | 10.1021/jm0498102 | |||
44319240 | 106966 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 374 | 6 | 1 | 2 | 4.8 | O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3 | 10.1016/s0960-894x(02)00485-7 | |||
CHEMBL314672 | 106966 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 374 | 6 | 1 | 2 | 4.8 | O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3 | 10.1016/s0960-894x(02)00485-7 | |||
135398737 | 958 | None | 57 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00166-9 | |||
135398737.0 | 958 | None | 57 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00166-9 | |||
38 | 958 | None | 57 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00166-9 | |||
722 | 958 | None | 57 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL42 | 958 | None | 57 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00166-9 | |||
DB00363 | 958 | None | 57 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00166-9 | |||
6540428 | 184970 | None | 1 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1016/s0960-894x(00)00166-9 | |||
6540428.0 | 184970 | None | 1 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL3989558 | 184970 | None | 1 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1016/s0960-894x(00)00166-9 | |||
CHEMBL485253 | 184970 | None | 1 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1016/s0960-894x(00)00166-9 | |||
DB00247 | 184970 | None | 1 | Rat | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1016/s0960-894x(00)00166-9 | |||
10571274 | 99513 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 42 | 3 | ChEMBL | 371 | 3 | 0 | 3 | 5.1 | COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 | 10.1021/jm030841r | |||
CHEMBL283065 | 99513 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 42 | 3 | ChEMBL | 371 | 3 | 0 | 3 | 5.1 | COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3 | 10.1021/jm030841r | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030841r | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030841r | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030841r | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030841r | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030841r | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 7.9 | 7.9 | -13 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030841r | |||
6540428 | 184970 | None | 1 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1021/jm030841r | |||
6540428.0 | 184970 | None | 1 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1021/jm030841r | |||
CHEMBL3989558 | 184970 | None | 1 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1021/jm030841r | |||
CHEMBL485253 | 184970 | None | 1 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1021/jm030841r | |||
DB00247 | 184970 | None | 1 | Human | Binding | pKi | = | 7.9 | 7.9 | -7 | 3 | ChEMBL | 353 | 4 | 2 | 4 | 1.9 | CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1 | 10.1021/jm030841r | |||
11151958 | 66992 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | -9 | 3 | ChEMBL | 339 | 7 | 0 | 3 | 4.8 | CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1 | 10.1021/jm0498102 | |||
CHEMBL186758 | 66992 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | -9 | 3 | ChEMBL | 339 | 7 | 0 | 3 | 4.8 | CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1 | 10.1021/jm0498102 | |||
71062123 | 93170 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 6 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 | 10.1016/j.bmc.2014.01.016 | |||
CHEMBL2442995 | 93170 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 6 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 | 10.1016/j.bmc.2014.01.016 | |||
71062123 | 93170 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 6 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 | 10.1016/j.bmcl.2013.09.025 | |||
CHEMBL2442995 | 93170 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 6 | 2 | ChEMBL | 472 | 11 | 1 | 5 | 4.8 | COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1 | 10.1016/j.bmcl.2013.09.025 | |||
76284453 | 105062 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 67 | 2 | ChEMBL | 476 | 10 | 1 | 5 | 4.0 | Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1 | 10.1016/j.bmc.2014.01.016 | |||
CHEMBL3113595 | 105062 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 67 | 2 | ChEMBL | 476 | 10 | 1 | 5 | 4.0 | Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1 | 10.1016/j.bmc.2014.01.016 | |||
90656713 | 111032 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 385 | 4 | 2 | 3 | 4.7 | Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1 | 10.1016/j.ejmech.2014.04.034 | |||
CHEMBL3262394 | 111032 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 385 | 4 | 2 | 3 | 4.7 | Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1 | 10.1016/j.ejmech.2014.04.034 | |||
162662399 | 182035 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -12 | 4 | ChEMBL | 399 | 7 | 1 | 5 | 3.1 | Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1 | 10.1016/j.ejmech.2020.112149 | |||
CHEMBL4779739 | 182035 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -12 | 4 | ChEMBL | 399 | 7 | 1 | 5 | 3.1 | Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1 | 10.1016/j.ejmech.2020.112149 | |||
11948707 | 166262 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -158 | 13 | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1021/acs.jmedchem.2c00633 | |||
CHEMBL426317 | 166262 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -158 | 13 | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1021/acs.jmedchem.2c00633 | |||
21830793 | 91869 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | -85 | 44 | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | |||
CHEMBL2413154 | 91869 | None | 12 | Human | Binding | pKi | = | 7.9 | 7.9 | -85 | 44 | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | |||
118728524 | 117783 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 2 | ChEMBL | 410 | 7 | 0 | 5 | 4.0 | O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2015.02.042 | |||
CHEMBL3401487 | 117783 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 3 | 2 | ChEMBL | 410 | 7 | 0 | 5 | 4.0 | O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2015.02.042 | |||
145990586 | 166939 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -9 | 11 | ChEMBL | 297 | 2 | 2 | 4 | 2.6 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | 10.1039/C7MD00656J | |||
CHEMBL4285281 | 166939 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -9 | 11 | ChEMBL | 297 | 2 | 2 | 4 | 2.6 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | 10.1039/C7MD00656J | |||
66801425 | 157278 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -39 | 4 | ChEMBL | 441 | 8 | 2 | 3 | 4.5 | Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1021/acs.jmedchem.7b00839 | |||
CHEMBL4075673 | 157278 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -39 | 4 | ChEMBL | 441 | 8 | 2 | 3 | 4.5 | Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 | 10.1021/acs.jmedchem.7b00839 | |||
66801354 | 112146 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -1 | 4 | ChEMBL | 450 | 7 | 1 | 6 | 3.5 | O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
CHEMBL3289977 | 112146 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -1 | 4 | ChEMBL | 450 | 7 | 1 | 6 | 3.5 | O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1 | 10.1021/jm401895u | |||
44437329 | 151689 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | -8 | 2 | ChEMBL | 692 | 18 | 0 |