Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	CHEMBL5093342	215541	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215541	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11329254	85187	0	None	-	1	Guinea pig	5.0	pEC50	=	5	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL225571	85187	0	None	-	1	Guinea pig	5.0	pEC50	=	5	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL5093342	215541	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215541	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	134138168	147666	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	27	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	135367816	164811	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367816	164811	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134138168	147666	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	23643870	92835	0	None	-	1	Guinea pig	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243955	92835	0	None	-	1	Guinea pig	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL5081379	214723	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5081379	214723	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	135367820	164797	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367820	164797	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5094493	215476	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5094493	215476	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	92042876	151312	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	5202	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	CHEMBL39	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	DB08839	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	92042876	151312	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	67268994	163944	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	67268994	163944	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164172	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164172	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	5	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	5202	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	CHEMBL39	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	DB08839	139	72	None	-9	27	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	11385992	84639	0	None	-	1	Guinea pig	4.8	pEC50	=	4.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL222477	84639	0	None	-	1	Guinea pig	4.8	pEC50	=	4.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	23643664	2335	8	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	8434	2335	8	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL243954	2335	8	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL5094234	215550	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215550	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5094234	215550	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215550	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11785183	84684	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84684	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	124247485	164045	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5084249	214882	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	124247485	164045	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5084249	214882	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	24825775	1511	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1511	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1511	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	24825775	1511	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1511	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1511	14	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	102364516	113516	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113516	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	11282296	143290	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	143290	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	11224758	2338	5	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2338	5	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2338	5	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	5	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	5202	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	CHEMBL39	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	DB08839	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	25107520	187569	0	None	-	1	Guinea pig	6.5	pEC50	=	6.5	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	CHEMBL494709	187569	0	None	-	1	Guinea pig	6.5	pEC50	=	6.5	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	42625440	170789	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL445334	170789	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	92042877	149151	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	149151	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	92042877	149151	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	149151	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	5	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	135367857	164580	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367857	164580	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	92042876	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	92042876	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	5202	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	CHEMBL39	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	DB08839	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	134138168	147666	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	5202	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	CHEMBL39	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	DB08839	139	72	None	-9	27	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	134138168	147666	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	25107648	187199	0	None	-	1	Guinea pig	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	CHEMBL492480	187199	0	None	-	1	Guinea pig	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	1809	134	32	None	-194	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	4	134	32	None	-194	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	CHEMBL18840	134	32	None	-194	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	5	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	92042876	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	92042876	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	151312	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL5074190	214291	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	214291	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5083607	214850	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	135453290	133581	33	None	-2818	7	Human	5.3	pEC50	=	5.3	Functional	Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133581	33	None	-2818	7	Human	5.3	pEC50	=	5.3	Functional	Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL5083607	214850	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	118709756	113520	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113520	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	25107716	2336	43	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	8436	2336	43	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	CHEMBL522691	2336	43	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	1809	134	32	None	-194	8	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	32	None	-194	8	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	32	None	-194	8	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	1809	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	4	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	CHEMBL18840	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	1809	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	4	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	CHEMBL18840	134	32	None	-2137	8	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	11432177	85093	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	85093	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL5083607	214850	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5083607	214850	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5202	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	CHEMBL39	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	DB08839	139	72	None	-9	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5	139	72	None	-9	27	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	5202	139	72	None	-9	27	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	CHEMBL39	139	72	None	-9	27	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	DB08839	139	72	None	-9	27	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	CHEMBL5091373	215544	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	215544	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	215544	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	215544	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	214468	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	214468	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074880	214316	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5074880	214316	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11431530	84596	0	None	-	1	Guinea pig	5.1	pEC50	=	5.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL222188	84596	0	None	-	1	Guinea pig	5.1	pEC50	=	5.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	24825775	1511	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1511	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1511	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	24825775	1511	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1511	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1511	14	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	214291	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	214291	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	72	None	-9	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	72	None	-9	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	72	None	-9	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	72	None	-9	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	23643663	92815	0	None	-	1	Guinea pig	6.1	pEC50	=	6.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243744	92815	0	None	-	1	Guinea pig	6.1	pEC50	=	6.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL5077293	214468	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	214468	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	3233	3486	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3486	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3486	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3486	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3486	44	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	4106	2485	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	5358812	2485	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	89	2485	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	CHEMBL93240	2485	22	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	3233	3486	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3486	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3486	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3486	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3486	44	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3233	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	3247	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	6604889	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	CHEMBL282199	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	DB13988	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	3233	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3486	44	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	4106	2485	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	5358812	2485	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	89	2485	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	CHEMBL93240	2485	22	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	164609529	184440	0	None	-36	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	184440	0	None	-36	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	11391654	180501	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	180501	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	127028798	138159	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769612	138159	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	142601335	186397	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	145946966	167573	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4209888	167573	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300899	167573	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	142601335	186397	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	4106	2485	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	5358812	2485	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	89	2485	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	CHEMBL93240	2485	22	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	117209912	185313	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	185313	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209912	185313	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	185313	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	135339817	181460	0	None	-1	5	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4764679	181460	0	None	-1	5	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	206	2476	16	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	68848	2476	16	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	CHEMBL12314	2476	16	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	156013673	177237	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4636148	177237	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	127028797	138308	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771309	138308	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	11536844	115096	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	115096	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	213046	2370	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	4168	2370	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	7461	2370	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	CHEMBL1237021	2370	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	DB08815	2370	59	None	1	17	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	142601318	185521	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185521	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601318	185521	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185521	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	11500509	120555	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120555	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120555	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	117209962	184845	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184845	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209962	184845	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184845	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601343	185579	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185579	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601343	185579	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185579	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	127029652	138303	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771222	138303	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	145947937	167699	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4207653	167699	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302655	167699	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	134141985	147151	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	147151	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	134141985	147151	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	147151	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	44348383	16271	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1016/j.ejmech.2012.11.042
	CHEMBL122536	16271	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1016/j.ejmech.2012.11.042
	4106	2485	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	5358812	2485	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	89	2485	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	CHEMBL93240	2485	22	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	102364516	113516	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113516	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	134157289	154057	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	154057	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	118709756	113520	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113520	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	134157289	154057	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	154057	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	117209857	185114	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185114	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	184979	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	145946714	167534	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4213352	167534	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300399	167534	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	142601328	184979	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209857	185114	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185114	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127029650	138241	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770581	138241	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	142601333	185739	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185739	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	184979	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367820	164797	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601333	185739	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185739	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	184979	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367820	164797	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164172	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	164172	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	156010865	177107	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633786	177107	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	71574210	86254	0	None	2	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312934	86254	0	None	2	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	206	2476	16	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	68848	2476	16	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	CHEMBL12314	2476	16	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	3233	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3233	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3486	44	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	2470	3626	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	3300	3626	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	5265	3626	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	99	3626	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	CHEMBL267930	3626	50	None	-5128	23	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	127028473	138248	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770639	138248	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	86288948	112599	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3233679	112599	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3302600	112599	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	71574302	86235	0	None	-4	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312637	86235	0	None	-4	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	142601323	185817	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185817	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	135367816	164811	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	117209971	186461	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186461	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367816	164811	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601323	185817	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185817	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	117209971	186461	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186461	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209918	186386	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186386	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209918	186386	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186386	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	11536843	115097	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	115097	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	22001618	81784	10	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164336	81784	10	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	59511191	185499	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185499	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	59511191	185499	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185499	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	2737389	187562	28	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL494675	187562	28	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	90656694	110968	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262428	110968	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	117209911	186305	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186305	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209911	186305	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186305	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	134154531	152704	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152704	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	71574306	86237	0	None	2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312639	86237	0	None	2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	134154531	152704	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152704	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	145947560	167684	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4212812	167684	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4302457	167684	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	11694810	120513	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120513	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120513	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	127028153	138138	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769441	138138	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	142601325	185845	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185845	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601325	185845	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185845	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209964	186110	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186110	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134137104	142667	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142667	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	134137104	142667	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142667	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	117209964	186110	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186110	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	155510732	169496	0	None	1	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4434876	169496	0	None	1	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	142601329	186493	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186493	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601329	186493	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186493	5	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	124247485	164045	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	124247485	164045	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601337	185946	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185946	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601337	185946	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185946	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601335	186397	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601335	186397	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	67268994	163944	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	67268994	163944	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	71574212	86255	0	None	-4	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312935	86255	0	None	-4	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	127028472	138146	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769534	138146	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	71574204	86238	0	None	18	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312640	86238	0	None	18	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	135367857	164580	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367857	164580	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	117209864	186010	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186010	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209864	186010	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186010	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209965	185223	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185223	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	185348	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185348	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209965	185223	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185223	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	185348	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185348	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209858	184530	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184530	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209858	184530	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184530	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	3233	3486	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3486	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3486	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3486	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3486	44	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3486	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3486	44	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	24768520	92978	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244161	92978	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3486	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3486	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3486	44	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3486	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3486	44	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	118731356	118166	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	118166	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	4806	3977	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	7351	3977	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051	3977	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL2104993	3977	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	DB09068	3977	88	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	118731351	118162	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	118162	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731356	118166	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	118166	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	118731351	118162	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	118162	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	240	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	None	-1	23	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	4223	3961	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3961	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3961	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3961	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3961	94	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	135398737	955	93	None	-13	92	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-13	92	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-13	92	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-13	92	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-13	92	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	3158	56237	27	None	-	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2585	800	103	None	-	22	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-	22	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-	22	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-	22	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-	22	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2247	504	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2284	3160	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-	29	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	2337	3232	77	None	-28	63	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-28	63	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-28	63	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-28	63	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-28	63	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	1890	2739	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2739	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2739	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2739	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2739	49	None	-	16	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	212	3777	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-7	25	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2389	3306	118	None	-8	68	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-8	68	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-8	68	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-8	68	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-8	68	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	135	2515	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-83	58	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	2543	3681	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3681	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3681	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3681	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3681	68	None	-93	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	191	402	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	402	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	402	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	402	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	402	98	None	-41	29	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-95	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-95	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-95	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-95	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	1400	1944	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1944	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1944	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1944	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1944	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1944	70	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	2726	916	68	None	-13	73	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-13	73	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-13	73	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-13	73	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-13	73	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1613	2333	53	None	-23	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-23	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-23	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-23	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-23	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	1353	1898	93	None	-263	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-263	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-263	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-263	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-263	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	392622	56282	95	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56282	95	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR7 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	4106	2485	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	5358812	2485	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	89	2485	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	CHEMBL93240	2485	22	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	5	139	72	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5202	139	72	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	CHEMBL39	139	72	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	DB08839	139	72	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5	139	72	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5202	139	72	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	CHEMBL39	139	72	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	DB08839	139	72	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	5202	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	CHEMBL39	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	DB08839	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	5	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	5202	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	CHEMBL39	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	DB08839	139	72	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	5	139	72	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	5202	139	72	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	CHEMBL39	139	72	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	DB08839	139	72	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	72548703	161543	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161543	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	5	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	5202	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	CHEMBL39	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	DB08839	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	5	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	5202	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	CHEMBL39	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	DB08839	139	72	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	5	139	72	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	5202	139	72	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	CHEMBL39	139	72	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	DB08839	139	72	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	5	139	72	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	5202	139	72	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	CHEMBL39	139	72	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	DB08839	139	72	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	11430418	18754	12	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	CHEMBL1278088	18754	12	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	44452114	160779	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL411442	160779	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452114	160779	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL411442	160779	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	72197486	102476	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102476	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102476	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	49864602	15632	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	373	5	0	4	3.0	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222138	15632	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	373	5	0	4	3.0	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.06.150
	44576978	187248	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.5	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL492793	187248	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.5	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	72197485	102462	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393244	102462	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040288	102462	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	42635388	187674	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	471	8	1	5	3.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL495250	187674	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	471	8	1	5	3.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452277	96050	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260073	96050	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452245	96117	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260514	96117	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452251	96206	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL260901	96206	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44452219	161213	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL411868	161213	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	54576142	66465	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL1852341	66465	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL3216098	66465	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	24882509	96210	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260907	96210	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452277	96050	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260073	96050	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452245	96117	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260514	96117	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	46232586	200899	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	9	0	4	4.6	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL601659	200899	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	9	0	4	4.6	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452251	96206	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL260901	96206	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44452219	161213	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL411868	161213	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	135	2515	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	1796	2515	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	4184	2515	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	CHEMBL6437	2515	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	DB06148	2515	43	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	46232818	200958	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602060	200958	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	11113605	10475	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL116735	10475	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	44451927	95998	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259776	95998	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452038	96212	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260969	96212	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	155561990	175687	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	557	11	1	7	4.5	CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL4582321	175687	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	557	11	1	7	4.5	CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2019.111705
	24882509	96210	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260907	96210	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	42635204	187735	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495678	187735	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	46232860	201038	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	494	10	0	6	3.9	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602677	201038	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	494	10	0	6	3.9	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	44451927	95998	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259776	95998	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452038	96212	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260969	96212	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232771	200832	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	443	10	0	5	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601249	200832	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	443	10	0	5	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	10067306	198843	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	363	5	0	5	3.1	CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	CHEMBL584046	198843	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	363	5	0	5	3.1	CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	46232622	200694	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL600012	200694	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	42635387	187668	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.6	O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495212	187668	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.6	O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	46232773	200928	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	511	10	0	5	4.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601855	200928	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	511	10	0	5	4.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	44452278	96051	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260074	96051	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452039	96213	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260970	96213	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452278	96051	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260074	96051	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452039	96213	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260970	96213	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44451930	95734	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL258524	95734	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	44451930	95734	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL258524	95734	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	10472158	196802	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	335	4	1	5	2.5	NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	CHEMBL565745	196802	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	335	4	1	5	2.5	NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	44452223	95962	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL259625	95962	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	42388965	187511	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL494428	187511	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	44452223	95962	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL259625	95962	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	53320009	56633	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1	10.1016/j.bmcl.2010.12.007
	CHEMBL1642116	56633	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1	10.1016/j.bmcl.2010.12.007
	169713	80132	20	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	CHEMBL21343	80132	20	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	11047568	10024	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	396	9	0	4	4.0	CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
	CHEMBL115249	10024	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	396	9	0	4	4.0	CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
	10885636	110989	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL326263	110989	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	46232732	200902	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	431	9	0	4	3.4	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601673	200902	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	431	9	0	4	3.4	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452276	159910	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL410722	159910	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452276	159910	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL410722	159910	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	12	1541	17	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
	6918513	1541	17	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
	CHEMBL267615	1541	17	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
	46232653	200996	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.8	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602284	200996	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.8	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	46232730	200868	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601457	200868	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	72197484	102467	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102467	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102467	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	18180076	15570	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	381	4	1	4	3.4	CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1221497	15570	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	381	4	1	4	3.4	CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	44452247	96158	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260706	96158	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452115	96349	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL261742	96349	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	44451980	155997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL406221	155997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	44452115	96349	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL261742	96349	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	44451980	155997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL406221	155997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	44452247	96158	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260706	96158	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232690	200937	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL601886	200937	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	155568606	176084	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4591601	176084	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	155568606	176084	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4591601	176084	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	11957735	199998	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	CHEMBL595449	199998	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	46232589	200790	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	515	11	0	6	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL600822	200790	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	515	11	0	6	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	19426635	205570	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
	CHEMBL81485	205570	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
	73351903	89666	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	360	3	2	4	3.1	Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376484	89666	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	360	3	2	4	3.1	Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	46232819	201131	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	493	10	0	5	4.5	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL603272	201131	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	493	10	0	5	4.5	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	44452166	95780	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL258785	95780	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452166	95780	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL258785	95780	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452005	95916	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL259407	95916	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	44451954	160351	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL411105	160351	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452005	95916	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259407	95916	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	44451954	160351	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL411105	160351	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232559	201071	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602882	201071	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452196	96000	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL259827	96000	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44451953	96250	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261149	96250	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452080	155753	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL405892	155753	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452144	96271	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261232	96271	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	5	139	72	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	5202	139	72	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	CHEMBL39	139	72	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	DB08839	139	72	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	3233	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	3247	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	6604889	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	CHEMBL282199	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	DB13988	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	3233	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	3247	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	6604889	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	CHEMBL282199	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	DB13988	3486	44	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	42388639	188030	0	None	-4	6	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2008.04.023
	CHEMBL497749	188030	0	None	-4	6	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2008.04.023
	44452170	166965	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL428781	166965	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452196	96000	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL259827	96000	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44451953	96250	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261149	96250	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	44452080	155753	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL405892	155753	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452144	96271	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL261232	96271	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	51003551	56640	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	449	3	0	5	3.8	CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.12.007
	CHEMBL1642123	56640	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	449	3	0	5	3.8	CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.12.007
	10907460	9796	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL113956	9796	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	49864292	15563	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	471	6	0	4	5.0	CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1221452	15563	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	471	6	0	4	5.0	CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	49864724	15660	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	409	5	0	4	3.8	CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222364	15660	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	409	5	0	4	3.8	CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	44452274	96207	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260902	96207	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452170	166965	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL428781	166965	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452274	96207	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260902	96207	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	11730467	10996	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL117537	10996	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	155531753	171622	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4465959	171622	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	155531753	171622	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4465959	171622	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	44451929	96034	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260003	96034	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44451929	96034	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260003	96034	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	42635570	187347	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1	10.1016/j.bmc.2008.04.023
	CHEMBL493416	187347	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1	10.1016/j.bmc.2008.04.023
	46232729	201433	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.3	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL604952	201433	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.3	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452139	96181	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.bmc.2007.11.049
	CHEMBL260804	96181	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.bmc.2007.11.049
	44452139	96181	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL260804	96181	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	44452302	96242	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261100	96242	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232689	200936	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	536	10	0	6	5.0	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601885	200936	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	536	10	0	6	5.0	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	44452302	96242	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261100	96242	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44451957	158472	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL409107	158472	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44451957	158472	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL409107	158472	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	11304851	154581	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	426	4	3	8	3.7	O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2	10.1016/j.bmcl.2007.05.011
	CHEMBL399203	154581	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	426	4	3	8	3.7	O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2	10.1016/j.bmcl.2007.05.011
	44452143	96270	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL261231	96270	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452143	96270	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL261231	96270	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44451952	160349	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL411104	160349	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44451952	160349	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL411104	160349	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44452006	157477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL407966	157477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452006	157477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL407966	157477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452037	96168	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260756	96168	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	44452273	158113	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL408717	158113	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	46866711	15638	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	5	0	4	4.2	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2010.06.150
	CHEMBL1222234	15638	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	5	0	4	4.2	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2010.06.150
	42388975	192697	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL522006	192697	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452037	96168	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260756	96168	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	44452273	158113	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL408717	158113	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	4106	2485	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	5358812	2485	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	89	2485	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	CHEMBL93240	2485	22	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	4223	3961	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	6918314	3961	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	7427	3961	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	CHEMBL439849	3961	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	DB06684	3961	94	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	10131112	1540	25	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
	8428	1540	25	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
	CHEMBL364005	1540	25	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
	49864289	15560	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	435	6	0	4	4.2	CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1221449	15560	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	435	6	0	4	4.2	CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	73347306	89665	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	230	1	2	1	3.0	Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376483	89665	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	230	1	2	1	3.0	Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	46232772	200834	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	11	0	6	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601250	200834	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	11	0	6	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	46232977	201173	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	453	8	1	5	3.7	COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL603499	201173	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	453	8	1	5	3.7	COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	42389293	187510	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL494427	187510	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	45278805	7418	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	484	7	1	4	5.2	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C	10.1016/j.bmcl.2010.01.093
	CHEMBL1086754	7418	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	484	7	1	4	5.2	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C	10.1016/j.bmcl.2010.01.093
	46232731	200869	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601458	200869	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	42635029	187409	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493810	187409	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	46232820	200829	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	531	9	0	4	5.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601220	200829	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	531	9	0	4	5.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452357	95877	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259236	95877	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452118	96324	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261573	96324	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232975	201074	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	482	9	0	5	4.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602889	201074	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	482	9	0	5	4.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452357	95877	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL259236	95877	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452118	96324	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261573	96324	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232978	201096	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	491	7	1	4	4.7	CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	CHEMBL603093	201096	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	491	7	1	4	4.7	CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	44451931	95735	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL258525	95735	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	11166042	166345	0	None	2	3	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL427518	166345	0	None	2	3	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	44451931	95735	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL258525	95735	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	73351905	89673	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	288	2	2	1	4.5	Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376491	89673	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	288	2	2	1	4.5	Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	42635571	187736	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	421	8	1	5	2.7	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL495685	187736	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	421	8	1	5	2.7	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	42635572	187773	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	403	8	1	5	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL495890	187773	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	403	8	1	5	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	42635028	193191	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL523519	193191	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	49864723	15659	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	6	0	4	4.2	CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222363	15659	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	6	0	4	4.2	CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	44452329	158714	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL409358	158714	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452329	158714	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL409358	158714	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	45278882	7420	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	512	9	1	4	6.1	CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2010.01.093
	CHEMBL1086756	7420	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	512	9	1	4	6.1	CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2010.01.093
	46232654	200997	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	506	9	0	5	5.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602285	200997	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	506	9	0	5	5.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452197	96044	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL260029	96044	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452081	96147	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260648	96147	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452008	95917	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL259408	95917	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452197	96044	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL260029	96044	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	44452081	96147	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260648	96147	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452171	168673	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL436700	168673	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	46232691	200938	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	524	9	0	5	5.2	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL601887	200938	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	524	9	0	5	5.2	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	11761059	10019	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	394	4	1	8	3.1	O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2	10.1021/jm010878g
	CHEMBL115229	10019	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	394	4	1	8	3.1	O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2	10.1021/jm010878g
	49864722	15658	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	395	4	0	4	3.4	CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222362	15658	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	395	4	0	4	3.4	CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	44452328	96052	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260076	96052	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452249	158526	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL409157	158526	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452171	168673	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL436700	168673	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452328	96052	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260076	96052	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452249	158526	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL409157	158526	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232560	200994	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.5	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602274	200994	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.5	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	45109862	7402	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	470	7	2	3	5.2	Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2010.01.093
	CHEMBL1086626	7402	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	470	7	2	3	5.2	Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2010.01.093
	44452222	95920	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL259415	95920	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	44452222	95920	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL259415	95920	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	44452117	96323	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261572	96323	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	42389467	187412	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493816	187412	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452217	95824	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259001	95824	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452117	96323	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261572	96323	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	36418162	187538	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	423	8	1	4	3.3	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL494573	187538	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	423	8	1	4	3.3	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	637308	183884	37	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	314	6	2	5	2.9	COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O	10.1021/np050301s
	CHEMBL481245	183884	37	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	314	6	2	5	2.9	COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O	10.1021/np050301s
	10337743	4045	18	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
	8429	4045	18	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
	CHEMBL571858	4045	18	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
	44452217	95824	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259001	95824	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	44452007	95869	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259199	95869	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	73354882	89664	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	290	1	2	1	3.6	Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376482	89664	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	290	1	2	1	3.6	Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	44452007	95869	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259199	95869	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	46232858	200760	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL600606	200760	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	45278883	7617	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	553	8	1	5	5.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1	10.1016/j.bmcl.2010.01.093
	CHEMBL1088313	7617	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	553	8	1	5	5.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1	10.1016/j.bmcl.2010.01.093
	72197668	102468	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393246	102468	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040325	102468	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	44451959	96251	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL261151	96251	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	44451984	96335	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261653	96335	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	46232623	200716	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	535	10	0	5	5.6	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL600210	200716	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	535	10	0	5	5.6	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	46232770	200818	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	458	10	0	6	3.2	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601037	200818	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	458	10	0	6	3.2	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	44451959	96251	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL261151	96251	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	44451984	96335	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261653	96335	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44451986	159340	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL410042	159340	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44451986	159340	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL410042	159340	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	10407367	196770	0	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	379	5	0	5	3.6	CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21	10.1016/j.bmc.2009.05.055
	CHEMBL565552	196770	0	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	379	5	0	5	3.6	CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21	10.1016/j.bmc.2009.05.055
	44452008	95917	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259408	95917	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	45278886	7618	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	564	8	1	4	6.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1	10.1016/j.bmcl.2010.01.093
	CHEMBL1088314	7618	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	564	8	1	4	6.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1	10.1016/j.bmcl.2010.01.093
	46233014	200995	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	441	7	1	4	3.9	CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	CHEMBL602279	200995	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	441	7	1	4	3.9	CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	42389457	187709	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495445	187709	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	44452193	96041	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260022	96041	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	44451982	96296	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL261434	96296	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	16	2240	8	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
	9847194	2240	8	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
	CHEMBL313714	2240	8	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
	44452193	96041	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260022	96041	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	44451982	96296	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL261434	96296	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	46700867	175966	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins	ChEMBL	377	14	1	4	5.0	CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1	10.1016/j.ejmech.2019.04.009
	CHEMBL4588956	175966	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins	ChEMBL	377	14	1	4	5.0	CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1	10.1016/j.ejmech.2019.04.009
	42635205	187771	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495884	187771	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	46232588	200934	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	485	10	0	5	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601872	200934	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	485	10	0	5	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	42635389	187345	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	433	9	1	6	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493402	187345	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	433	9	1	6	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452275	96208	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL260903	96208	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44452298	96283	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL261337	96283	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452275	96208	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL260903	96208	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44452298	96283	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261337	96283	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	46232861	201070	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	532	9	0	5	4.9	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602878	201070	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	532	9	0	5	4.9	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	54577891	66545	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL1852516	66545	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL3216758	66545	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	44451979	96295	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261433	96295	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	72198754	90851	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	CHEMBL2392349	90851	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	53320010	56634	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.12.007
	CHEMBL1642117	56634	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.12.007
	44451979	96295	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261433	96295	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	185617	186530	86	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	462	4	7	11	-0.2	O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O	10.1021/np0205102
	CHEMBL487805	186530	86	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	462	4	7	11	-0.2	O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O	10.1021/np0205102
	44452279	161264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL412153	161264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44452279	161264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL412153	161264	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	44452331	96078	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260249	96078	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452331	96078	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260249	96078	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232976	201095	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	423	7	1	4	3.7	CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	CHEMBL603092	201095	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	423	7	1	4	3.7	CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	10949380	163999	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	399	3	1	6	4.3	Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1	10.1021/jm010878g
	CHEMBL420863	163999	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	399	3	1	6	4.3	Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1	10.1021/jm010878g
	46232620	200813	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	553	10	0	5	5.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601022	200813	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	553	10	0	5	5.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	44452010	95961	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL259619	95961	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	44452141	96223	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL261018	96223	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452010	95961	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259619	95961	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	44452141	96223	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261018	96223	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	42389129	193087	2	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	409	7	1	4	3.3	O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL522694	193087	2	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	409	7	1	4	3.3	O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	73356443	89672	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	294	2	2	2	4.6	Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376490	89672	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	294	2	2	2	4.6	Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	44452221	95919	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL259414	95919	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	44452221	95919	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL259414	95919	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44452199	96042	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260023	96042	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452199	96042	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL260023	96042	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	11071079	110566	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL325516	110566	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	44452332	96079	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260250	96079	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452362	96480	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL262589	96480	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	44452324	96209	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260906	96209	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452332	96079	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL260250	96079	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452362	96480	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL262589	96480	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	44452324	96209	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260906	96209	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452327	96243	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL261102	96243	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	46232859	200761	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	464	9	0	5	3.8	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL600607	200761	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	464	9	0	5	3.8	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452327	96243	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL261102	96243	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	10937901	9878	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	CHEMBL114379	9878	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	44452040	96214	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260971	96214	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452041	96258	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261187	96258	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452040	96214	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260971	96214	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452041	96258	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261187	96258	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452243	158524	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL409156	158524	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	44452243	158524	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL409156	158524	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452224	95963	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259626	95963	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452224	95963	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259626	95963	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452246	96157	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260705	96157	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44342270	9898	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	CHEMBL114484	9898	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	44452246	96157	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260705	96157	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	46232587	201561	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	500	10	0	6	4.4	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL605582	201561	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	500	10	0	6	4.4	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	46232652	200967	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	573	9	0	4	6.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602087	200967	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	573	9	0	4	6.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	42635027	187373	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493625	187373	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452042	160140	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL410922	160140	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452167	95821	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL258995	95821	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	44452042	160140	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL410922	160140	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452167	95821	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL258995	95821	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	44452142	96224	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261019	96224	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452142	96224	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261019	96224	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452359	159342	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL410043	159342	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	44452359	159342	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL410043	159342	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452082	159376	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL410075	159376	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232817	200932	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	461	10	0	5	3.4	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601859	200932	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	461	10	0	5	3.4	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	44452082	159376	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL410075	159376	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	42389303	187410	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493811	187410	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452301	96241	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261099	96241	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44451985	96336	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261654	96336	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452301	96241	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261099	96241	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	44451985	96336	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261654	96336	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	14748689	187249	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	373	8	1	4	2.2	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/j.bmc.2008.04.023
	CHEMBL492794	187249	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	373	8	1	4	2.2	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/j.bmc.2008.04.023
	44452305	96280	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL261291	96280	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	44452305	96280	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL261291	96280	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	44452078	95810	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL258956	95810	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	44452078	95810	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL258956	95810	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	44452195	157043	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL407411	157043	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	44452195	157043	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.bmc.2007.11.049
	CHEMBL407411	157043	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.bmc.2007.11.049
	46232621	201589	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	503	10	0	5	4.6	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL605787	201589	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	503	10	0	5	4.6	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	3066250	70257	2	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	242	2	2	2	2.9	COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1	10.1016/j.bmcl.2005.06.067
	CHEMBL194305	70257	2	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	242	2	2	2	2.9	COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1	10.1016/j.bmcl.2005.06.067
	11005810	10434	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL116463	10434	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	71061887	93089	0	None	66	2	Human	8.9	pKd	=	8.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442996	93089	0	None	66	2	Human	8.9	pKd	=	8.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	11785183	84684	0	None	-1	4	Human	7.8	pKd	=	7.8	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84684	0	None	-1	4	Human	7.8	pKd	=	7.8	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	11224758	2338	5	None	-4	6	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2338	5	None	-4	6	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2338	5	None	-4	6	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	11282296	143290	0	None	-6	4	Human	7.6	pKd	=	7.6	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	143290	0	None	-6	4	Human	7.6	pKd	=	7.6	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	5	139	72	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	5202	139	72	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	CHEMBL39	139	72	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	DB08839	139	72	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	1809	134	32	None	-7	37	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	32	None	-7	37	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	32	None	-7	37	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	11191128	85181	0	None	-5	4	Human	7.2	pKd	=	7.2	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL225512	85181	0	None	-5	4	Human	7.2	pKd	=	7.2	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	11432177	85093	0	None	-1	4	Human	8.0	pKd	=	8.0	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	85093	0	None	-1	4	Human	8.0	pKd	=	8.0	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	3233	3486	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	3247	3486	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	6604889	3486	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	CHEMBL282199	3486	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	DB13988	3486	44	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	1809	134	32	None	-2	37	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
	4	134	32	None	-2	37	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
	CHEMBL18840	134	32	None	-2	37	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
	56944082	112051	0	None	169	4	Human	10.0	pKi	=	10	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	8	1	6	3.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289972	112051	0	None	169	4	Human	10.0	pKi	=	10	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	8	1	6	3.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	5	139	72	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	5202	139	72	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	CHEMBL39	139	72	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	DB08839	139	72	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	1809	134	32	None	-2	37	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
	4	134	32	None	-2	37	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
	CHEMBL18840	134	32	None	-2	37	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
	5	139	72	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	5202	139	72	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	CHEMBL39	139	72	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	DB08839	139	72	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	23643664	2335	8	None	-1	5	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	8434	2335	8	None	-1	5	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL243954	2335	8	None	-1	5	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	42631003	199595	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
	CHEMBL592752	199595	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
	42631003	199595	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1021/acs.jmedchem.7b01898
	CHEMBL592752	199595	13	None	2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1021/acs.jmedchem.7b01898
	168271260	190492	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	432	7	0	5	3.0	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5179460	190492	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	432	7	0	5	3.0	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1	10.1021/acs.jmedchem.2c00633
	5	139	72	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	5202	139	72	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	CHEMBL39	139	72	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	DB08839	139	72	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	10450593	124239	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2010.03.012
	CHEMBL363452	124239	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2010.03.012
	10450593	124239	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL363452	124239	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	66801551	112096	0	None	3	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	519	8	1	6	5.6	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3290016	112096	0	None	3	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	519	8	1	6	5.6	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	46224879	201524	3	None	1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL605405	201524	3	None	1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	168287666	191636	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5196234	191636	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	11224758	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
	8435	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
	CHEMBL225284	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
	11224758	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
	8435	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
	CHEMBL225284	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
	11224758	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
	8435	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
	CHEMBL225284	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
	11224758	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
	8435	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
	CHEMBL225284	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
	11224758	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
	8435	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
	CHEMBL225284	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
	11224758	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2338	5	None	4	6	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	5	139	72	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	5202	139	72	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	CHEMBL39	139	72	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	DB08839	139	72	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	10402615	202494	0	None	20	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1021/jm030826m
	CHEMBL611472	202494	0	None	20	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1021/jm030826m
	42631003	199595	13	None	2	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL592752	199595	13	None	2	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	145989143	167162	0	None	2	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	399	5	1	2	5.3	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4291322	167162	0	None	2	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	399	5	1	2	5.3	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	44393091	65327	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182923	65327	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393169	65566	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL183277	65566	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	71454999	81393	0	None	169	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159465	81393	0	None	169	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	1809	134	32	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
	4	134	32	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
	CHEMBL18840	134	32	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
	46233450	200220	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	357	6	0	1	6.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2010.01.035
	CHEMBL596959	200220	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	357	6	0	1	6.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2010.01.035
	10413595	161817	0	None	-1	11	Human	9.5	pKi	=	9.5	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL414628	161817	0	None	-1	11	Human	9.5	pKi	=	9.5	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	168283786	190846	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5184712	190846	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	3233	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3486	44	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	1809	134	32	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
	4	134	32	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
	CHEMBL18840	134	32	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
	11524413	96346	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL261719	96346	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	11589069	96218	0	None	10	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
	CHEMBL260994	96218	0	None	10	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
	11524413	96346	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL261719	96346	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	11524413	96346	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL261719	96346	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	44126269	201461	5	None	2	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	CHEMBL605081	201461	5	None	2	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	1809	134	32	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
	4	134	32	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
	CHEMBL18840	134	32	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
	44393073	64433	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL181356	64433	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393092	64550	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL181605	64550	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393193	65611	0	None	32	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL183423	65611	0	None	32	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393192	66223	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL184607	66223	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	2389	3306	118	None	-8	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	5073	3306	118	None	-8	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	96	3306	118	None	-8	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	CHEMBL85	3306	118	None	-8	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	DB00734	3306	118	None	-8	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	145985050	165666	0	None	-3	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245263	165666	0	None	-3	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	1809	134	32	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
	4	134	32	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
	CHEMBL18840	134	32	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
	24854273	158348	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL408976	158348	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	56944763	112084	0	None	4	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3290004	112084	0	None	4	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	44266163	97026	1	None	4	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	1	2	4.4	O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL267062	97026	1	None	4	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	1	2	4.4	O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(03)00077-5
	24854273	158348	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL408976	158348	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24854187	96198	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL260872	96198	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	24854187	96198	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL260872	96198	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	132578545	154534	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3898250	154534	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3991133	154534	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	25192947	164642	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	CHEMBL4216782	164642	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	25192947	164642	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL4216782	164642	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1021/acs.jmedchem.7b01898
	1809	134	32	None	-7	37	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
	4	134	32	None	-7	37	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
	CHEMBL18840	134	32	None	-7	37	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
	11653869	96264	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	CHEMBL261209	96264	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	11653869	96264	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	CHEMBL261209	96264	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	16362	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	2172	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	90	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	CHEMBL1423	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	DB01100	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	213046	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	4168	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	7461	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	CHEMBL1237021	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	DB08815	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	213046	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	4168	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	7461	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	CHEMBL1237021	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	DB08815	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	132578545	154534	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3898250	154534	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3991133	154534	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	66801167	112082	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	CHEMBL3290002	112082	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	1809	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	4	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	CHEMBL18840	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	1809	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	4	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	CHEMBL18840	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	44340836	161710	0	None	60	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	471	7	1	4	4.4	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL413707	161710	0	None	60	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	471	7	1	4	4.4	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(02)00690-x
	1809	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
	4	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
	CHEMBL18840	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
	1809	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
	1809	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
	4	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
	CHEMBL18840	134	32	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4106	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	5358812	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	89	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	CHEMBL93240	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	145983405	166414	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4277476	166414	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	44266221	208343	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	3	4.5	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9951	208343	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	3	4.5	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	4106	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	5358812	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	89	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	CHEMBL93240	2485	22	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	25107716	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	8436	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	CHEMBL522691	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	25107716	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	8436	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	CHEMBL522691	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	25107716	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
	8436	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
	CHEMBL522691	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
	25107716	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
	8436	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
	CHEMBL522691	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
	25107716	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	8436	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	CHEMBL522691	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	23642275	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	8433	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	CHEMBL2164327	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	9881600	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111705
	CHEMBL161765	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111705
	44393180	66635	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185384	66635	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	23642275	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	8433	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	CHEMBL2164327	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	9881600	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111690
	CHEMBL161765	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111690
	23642275	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
	8433	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
	CHEMBL2164327	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
	9881600	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL161765	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	66803474	156292	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	429	6	2	3	4.2	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4065568	156292	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	429	6	2	3	4.2	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	11681111	120558	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343666	120558	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545815	120558	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	4431	2710	25	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
	73	2710	25	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
	CHEMBL8618	2710	25	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
	9881600	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL161765	55167	4	None	8	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	24854371	95846	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL259087	95846	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	23642275	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	8433	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	CHEMBL2164327	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	56933434	112070	0	None	6	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	431	7	1	5	3.8	Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289991	112070	0	None	6	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	431	7	1	5	3.8	Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	25107716	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
	8436	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
	CHEMBL522691	2336	43	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
	24853955	156169	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL406414	156169	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	5	139	72	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	5202	139	72	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	CHEMBL39	139	72	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	DB08839	139	72	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	44437334	150474	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL395444	150474	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	24854371	95846	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL259087	95846	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24854037	95845	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	7	1	3	5.2	CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL259086	95845	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	7	1	3	5.2	CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24854041	95950	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	CHEMBL259549	95950	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	9934709	167800	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL430706	167800	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(02)00690-x
	9934709	167800	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2010.03.012
	CHEMBL430706	167800	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2010.03.012
	102364516	113516	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1016/j.ejmech.2019.111705
	CHEMBL3321794	113516	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1016/j.ejmech.2019.111705
	10015688	51644	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL158402	51644	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	10015688	51644	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL158402	51644	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmc.2010.01.035
	102364516	113516	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113516	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	66801263	112049	0	None	14	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289970	112049	0	None	14	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	66801210	112097	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	535	8	1	6	6.1	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12	10.1021/jm401895u
	CHEMBL3290017	112097	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	535	8	1	6	6.1	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12	10.1021/jm401895u
	44340854	10027	0	None	61	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	493	6	2	6	4.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL115262	10027	0	None	61	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	493	6	2	6	4.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(02)00690-x
	3233	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	3247	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	6604889	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	CHEMBL282199	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	DB13988	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	3233	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	3247	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	6604889	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	CHEMBL282199	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	DB13988	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	3233	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	3247	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	6604889	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	CHEMBL282199	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	DB13988	3486	44	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	168297777	192880	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5184185	192880	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5222088	192880	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
	145974165	164564	0	None	8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	410	5	0	2	6.0	Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	CHEMBL4215605	164564	0	None	8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	410	5	0	2	6.0	Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	118717217	120550	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343667	120550	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545762	120550	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	24829343	158997	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1016/j.ejmech.2019.111705
	CHEMBL409662	158997	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1016/j.ejmech.2019.111705
	24829343	158997	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm200547z
	CHEMBL409662	158997	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm200547z
	24829343	158997	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	CHEMBL409662	158997	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	145991084	166846	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4285796	166846	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	44340835	10376	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	499	7	1	4	5.0	O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL116292	10376	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	499	7	1	4	5.0	O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	155568606	176084	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4591601	176084	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	5	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	5202	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	CHEMBL39	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	DB08839	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	5	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	5202	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	CHEMBL39	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	DB08839	139	72	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	66801158	112057	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	464	8	1	6	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289978	112057	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	464	8	1	6	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	56944665	112083	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	CHEMBL3290003	112083	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	56944668	112085	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3290005	112085	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	25107518	187260	0	None	20	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1021/jm800615e
	CHEMBL492871	187260	0	None	20	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1021/jm800615e
	9971032	202182	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	282	2	1	1	4.0	Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C	10.1021/jm030826m
	CHEMBL609675	202182	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	282	2	1	1	4.0	Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C	10.1021/jm030826m
	44340850	9870	0	None	22	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	483	7	1	4	4.4	O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL114345	9870	0	None	22	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	483	7	1	4	4.4	O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	155516399	170047	0	None	47	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	368	6	1	5	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4443201	170047	0	None	47	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	368	6	1	5	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	10069973	52369	0	None	4	5	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	407	9	0	6	4.4	COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1021/jm020994z
	CHEMBL159022	52369	0	None	4	5	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	407	9	0	6	4.4	COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1021/jm020994z
	155552188	174040	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	2	3	4.6	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4544153	174040	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	2	3	4.6	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1	10.1016/j.bmcl.2019.126703
	1809	134	32	None	-7	37	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
	4	134	32	None	-7	37	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
	CHEMBL18840	134	32	None	-7	37	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
	4106	2485	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	5358812	2485	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	89	2485	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	CHEMBL93240	2485	22	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	66801234	112074	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	469	7	1	5	4.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289995	112074	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	469	7	1	5	4.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	66801271	112078	0	None	5	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	423	7	1	6	3.6	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289999	112078	0	None	5	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	423	7	1	6	3.6	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	66801139	112089	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	CHEMBL3290009	112089	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	23643870	92835	0	None	35	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243955	92835	0	None	35	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	44437328	90953	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239656	90953	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	1809	134	32	None	-7	37	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
	4	134	32	None	-7	37	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
	CHEMBL18840	134	32	None	-7	37	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
	107	141	121	None	-1	31	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
	1833	141	121	None	-1	31	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
	CHEMBL8165	141	121	None	-1	31	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
	25107520	187569	0	None	70	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	CHEMBL494709	187569	0	None	70	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	141745651	175322	0	None	1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	380	4	1	4	4.3	Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	CHEMBL4574299	175322	0	None	1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	380	4	1	4	4.3	Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	118713589	114347	0	None	10	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	6	0	5	4.0	Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331258	114347	0	None	10	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	6	0	5	4.0	Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	44393134	64819	0	None	39	2	Human	9.0	pKi	=	9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182071	64819	0	None	39	2	Human	9.0	pKi	=	9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	4184551	192637	9	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	352	5	1	4	2.7	CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1	10.1016/j.bmcl.2021.128275
	CHEMBL5218527	192637	9	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	352	5	1	4	2.7	CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1	10.1016/j.bmcl.2021.128275
	3233	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	3247	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	6604889	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	CHEMBL282199	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	DB13988	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	7059581	167021	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1016/s0960-894x(00)00166-9
	CHEMBL428892	167021	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1016/s0960-894x(00)00166-9
	3233	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	3247	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	6604889	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	CHEMBL282199	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	DB13988	3486	44	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	11725453	99052	0	None	1	6	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/s0960-894x(02)00438-9
	CHEMBL28056	99052	0	None	1	6	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/s0960-894x(02)00438-9
	3233	3486	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	3247	3486	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	6604889	3486	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	CHEMBL282199	3486	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	DB13988	3486	44	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	7059581	167021	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm049743b
	CHEMBL428892	167021	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm049743b
	127025243	137718	0	None	60	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759205	137718	0	None	60	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1	10.1016/j.ejmech.2015.11.040
	145985692	165420	0	None	-3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239091	165420	0	None	-3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626161	165575	0	None	-1	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242858	165575	0	None	-1	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626129	165618	0	None	3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243848	165618	0	None	3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	156021386	178066	0	None	7	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4647808	178066	0	None	7	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	4106	2485	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	5358812	2485	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	89	2485	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	CHEMBL93240	2485	22	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	66803595	159704	0	None	1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	431	6	3	4	3.6	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4104622	159704	0	None	1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	431	6	3	4	3.6	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	155531753	171622	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4465959	171622	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	19605739	169988	14	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	204	3	3	2	1.4	NCCc1c[nH]c2ccc(C(=O)O)cc12	10.1016/j.ejmech.2019.111705
	CHEMBL4442472	169988	14	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	204	3	3	2	1.4	NCCc1c[nH]c2ccc(C(=O)O)cc12	10.1016/j.ejmech.2019.111705
	2389	3306	118	None	-8	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	5073	3306	118	None	-8	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	96	3306	118	None	-8	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	CHEMBL85	3306	118	None	-8	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	DB00734	3306	118	None	-8	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	16006607	95643	4	None	10	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	CHEMBL258075	95643	4	None	10	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	7059581	167021	3	None	1	2	Human	9.0	pKi	=	9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm030841r
	CHEMBL428892	167021	3	None	1	2	Human	9.0	pKi	=	9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm030841r
	11661471	159504	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	408	7	1	2	5.9	CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410226	159504	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	408	7	1	2	5.9	CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	10346043	47090	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)	ChEMBL	503	5	2	5	3.4	COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL154274	47090	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)	ChEMBL	503	5	2	5	3.4	COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	10379532	99247	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmcl.2010.03.012
	CHEMBL281923	99247	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmcl.2010.03.012
	10062885	99248	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm060959i
	CHEMBL281924	99248	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm060959i
	78108787	191943	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	363	6	1	3	4.0	Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL5201016	191943	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	363	6	1	3	4.0	Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.2c00633
	10379532	99247	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	CHEMBL281923	99247	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	10062885	99248	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	CHEMBL281924	99248	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	10062885	99248	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmc.2020.115578
	CHEMBL281924	99248	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmc.2020.115578
	10379532	99247	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL281923	99247	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	10062885	99248	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL281924	99248	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	24854044	97270	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm200547z
	CHEMBL269083	97270	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm200547z
	56944664	112046	0	None	23	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	428	8	1	6	3.0	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289968	112046	0	None	23	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	428	8	1	6	3.0	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	56944764	112069	0	None	3	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	417	6	1	5	3.4	Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289990	112069	0	None	3	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	417	6	1	5	3.4	Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	23643663	92815	0	None	13	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243744	92815	0	None	13	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	145981875	166497	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4278933	166497	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	145992877	166872	0	None	11	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	413	6	1	2	5.7	Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4286174	166872	0	None	11	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	413	6	1	2	5.7	Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	3044582	192389	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2	10.1016/j.ejmech.2022.114218
	CHEMBL5208064	192389	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2	10.1016/j.ejmech.2022.114218
	11524003	159503	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410225	159503	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	118717211	120552	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343663	120552	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545801	120552	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	11524003	159503	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL410225	159503	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	66801346	112072	0	None	1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	485	7	1	5	4.8	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289993	112072	0	None	1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	485	7	1	5	4.8	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	24854181	96403	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL262068	96403	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	3233	3486	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	3247	3486	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	6604889	3486	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	CHEMBL282199	3486	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	DB13988	3486	44	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	24825775	1511	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1511	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1511	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	15803947	52324	1	None	13	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	161	3	0	2	2.1	CN(C)CCSC(C)(C)C	10.1016/j.bmcl.2003.11.050
	CHEMBL158973	52324	1	None	13	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	161	3	0	2	2.1	CN(C)CCSC(C)(C)C	10.1016/j.bmcl.2003.11.050
	24825775	1511	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1511	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1511	14	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3233	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	3247	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	6604889	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	DB13988	3486	44	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	118717223	120556	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343671	120556	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545813	120556	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	56944859	112081	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	CHEMBL3290001	112081	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	56944384	112094	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	521	8	1	6	5.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3290014	112094	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	521	8	1	6	5.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	66801565	112100	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	474	7	1	7	4.1	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3290020	112100	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	474	7	1	7	4.1	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	2389	3306	118	None	-7	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	5073	3306	118	None	-7	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	96	3306	118	None	-7	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	CHEMBL85	3306	118	None	-7	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	DB00734	3306	118	None	-7	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	60196080	81778	2	None	12	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	CHEMBL2164330	81778	2	None	12	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	2737389	187562	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL494675	187562	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	11637931	120557	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343665	120557	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545814	120557	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	5	139	72	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	5202	139	72	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	CHEMBL39	139	72	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	DB08839	139	72	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	56944666	112086	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3290006	112086	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	2737389	187562	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1039/C8MD00313K
	CHEMBL494675	187562	28	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1039/C8MD00313K
	162643494	181625	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4775997	181625	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	24854111	95730	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL258496	95730	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	66801229	112030	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	6	1	6	3.6	O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289952	112030	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	6	1	6	3.6	O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	66800939	112031	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	7	1	6	3.9	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289953	112031	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	7	1	6	3.9	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	56944667	112071	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	445	8	1	5	4.2	Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289992	112071	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	445	8	1	5	4.2	Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	24854183	95873	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	413	7	1	3	4.6	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL259216	95873	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	413	7	1	3	4.6	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL5094234	215550	0	None	2	8	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215550	0	None	2	8	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134155116	150944	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3958215	150944	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL5091373	215544	0	None	1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134155116	150944	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3958215	150944	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	132525570	163621	0	None	6	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	300	5	0	5	2.8	CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	CHEMBL4204059	163621	0	None	6	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	300	5	0	5	2.8	CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	56944565	112022	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	444	8	1	6	3.5	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289944	112022	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	444	8	1	6	3.5	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	56944383	112092	0	None	-3	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290012	112092	0	None	-3	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	44437330	152165	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396844	152165	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44266268	207774	0	None	10	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	394	5	0	3	3.8	O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9616	207774	0	None	10	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	394	5	0	3	3.8	O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	162652285	180251	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4750664	180251	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	162654074	180555	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4754138	180555	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	11500509	120555	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120555	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120555	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	66801107	112019	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	430	7	1	6	3.1	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289709	112019	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	430	7	1	6	3.1	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	4106	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	5358812	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	89	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	CHEMBL93240	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	4106	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
	5358812	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
	89	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
	CHEMBL93240	2485	22	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2023.117256
	118713592	114351	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331261	114351	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	11187960	66200	0	None	6	2	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	CHEMBL184535	66200	0	None	6	2	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	44437329	151576	0	None	-8	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396349	151576	0	None	-8	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	1809	134	32	None	-2	37	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
	4	134	32	None	-2	37	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
	CHEMBL18840	134	32	None	-2	37	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
	118717220	120554	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343669	120554	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545811	120554	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	56944564	112032	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	480	8	1	6	4.3	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289954	112032	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	480	8	1	6	4.3	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	24854185	157684	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	439	8	1	3	5.6	CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL408191	157684	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	439	8	1	3	5.6	CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	44340834	110198	0	None	169	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	494	6	1	6	4.0	O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL323778	110198	0	None	169	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	494	6	1	6	4.0	O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	155567938	176010	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	386	8	2	5	2.8	NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	CHEMBL4590226	176010	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	386	8	2	5	2.8	NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	10834268	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm0104264
	CHEMBL428494	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm0104264
	10834268	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm980519u
	CHEMBL428494	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm980519u
	168288462	191681	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5196950	191681	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	60195993	81782	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2ccccc2N2CCNCC2)cc1C	10.1021/jm3003679
	CHEMBL2164334	81782	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2ccccc2N2CCNCC2)cc1C	10.1021/jm3003679
	3233	3486	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	3247	3486	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	6604889	3486	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	CHEMBL282199	3486	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	DB13988	3486	44	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	56944383	112092	0	None	-3	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290012	112092	0	None	-3	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	24854105	157909	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	CHEMBL408450	157909	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	155542678	173138	0	None	281	2	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	487	7	1	4	4.9	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL4521657	173138	0	None	281	2	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	487	7	1	4	4.9	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2019.111705
	10028436	3506	5	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
	3237	3506	5	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
	CHEMBL95104	3506	5	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
	44396223	123784	0	None	281	2	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	486	7	0	4	5.0	O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1021/jm0498102
	CHEMBL362354	123784	0	None	281	2	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	486	7	0	4	5.0	O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1021/jm0498102
	10573876	10430	0	None	199	7	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
	CHEMBL116448	10430	0	None	199	7	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
	44368731	119665	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm030841r
	CHEMBL347286	119665	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm030841r
	11047374	18877	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL12846	18877	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10834268	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL428494	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	10834268	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm030841r
	CHEMBL428494	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm030841r
	10433930	51059	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL157910	51059	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	10028436	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	3237	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	CHEMBL95104	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	46203758	124522	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640556	124522	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	44393072	169252	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	8	2	6	3.7	C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL441312	169252	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	8	2	6	3.7	C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	2389	3306	118	None	-8	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	5073	3306	118	None	-8	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	96	3306	118	None	-8	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	CHEMBL85	3306	118	None	-8	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	DB00734	3306	118	None	-8	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	10171	57	18	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
	272	57	18	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
	CHEMBL274384	57	18	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
	10499156	114064	1	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	CHEMBL332701	114064	1	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	10249573	207570	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL94984	207570	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	44368705	45838	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	CHEMBL153156	45838	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	10596321	207441	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	CHEMBL94261	207441	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	44460708	205585	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	CHEMBL81607	205585	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	10249573	207570	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	CHEMBL94984	207570	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	44461065	205521	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	389	4	0	3	4.4	Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81022	205521	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	389	4	0	3	4.4	Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	44460708	205585	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81607	205585	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	10249573	207570	0	None	-1	11	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm049743b
	CHEMBL94984	207570	0	None	-1	11	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm049743b
	5	139	72	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	5202	139	72	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	CHEMBL39	139	72	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	DB08839	139	72	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	9894665	103786	1	None	-30	8	Human	8.0	pKi	=	8	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
	CHEMBL309106	103786	1	None	-30	8	Human	8.0	pKi	=	8	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
	46203758	124522	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640556	124522	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	CHEMBL5074880	214316	0	None	1	9	Human	8.0	pKi	=	8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	127028472	138146	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769534	138146	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	127038281	137062	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	494	10	0	6	4.0	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1016/j.bmc.2015.11.041
	CHEMBL3747240	137062	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	494	10	0	6	4.0	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1016/j.bmc.2015.11.041
	127041259	137073	0	None	4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	420	8	0	6	2.7	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747459	137073	0	None	4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	420	8	0	6	2.7	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	145985505	165601	0	None	-3	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243579	165601	0	None	-3	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	134145903	148854	0	None	5	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3941529	148854	0	None	5	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	71456781	81399	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	3.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159471	81399	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	3.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	71458651	81405	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	439	8	1	5	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159477	81405	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	439	8	1	5	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1	10.1016/j.ejmech.2012.07.043
	71456784	81420	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159492	81420	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	242	469	124	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	34	469	124	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	60795	469	124	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	CHEMBL1112	469	124	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	DB01238	469	124	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	118731352	118163	0	None	2	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	510	9	1	4	4.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409036	118163	0	None	2	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	510	9	1	4	4.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731362	118172	0	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	564	8	0	4	5.6	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409045	118172	0	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	564	8	0	4	5.6	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	145947590	167681	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4170657	167681	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302436	167681	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145947976	167690	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4168743	167690	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302539	167690	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	56944952	157343	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4077937	157343	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	24854103	96126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	CHEMBL260551	96126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	127052458	140715	0	None	3	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140715	0	None	3	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	90644074	112045	0	None	151	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	414	7	1	6	2.6	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289967	112045	0	None	151	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	414	7	1	6	2.6	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	56943695	112095	0	None	-4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	505	7	1	6	5.2	Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3290015	112095	0	None	-4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	505	7	1	6	5.2	Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	10171	57	18	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
	272	57	18	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
	CHEMBL274384	57	18	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
	90656682	110951	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	6	2	4	3.0	Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262411	110951	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	6	2	4	3.0	Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	11525867	96197	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	CHEMBL260870	96197	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	44266289	98135	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	404	4	1	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273872	98135	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	404	4	1	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	127052458	140715	0	None	3	7	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140715	0	None	3	7	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	242	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	34	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	60795	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	CHEMBL1112	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	DB01238	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	242	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	34	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	60795	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	CHEMBL1112	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	DB01238	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	242	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	34	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	60795	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	CHEMBL1112	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	DB01238	469	124	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	10714877	114345	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	6	3.2	COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331256	114345	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	6	3.2	COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	11825614	102583	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	403	6	1	3	4.5	Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL304167	102583	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	403	6	1	3	4.5	Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	46204726	124541	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640574	124541	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	46204726	124541	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640574	124541	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	134155476	151201	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3960056	151201	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	2726	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	621	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	83	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	CHEMBL71	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	DB00477	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	76336186	106375	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121435	106375	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139448	106375	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	11667458	65969	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	350	6	1	4	3.1	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	CHEMBL1836788	65969	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	350	6	1	4	3.1	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	11407754	98153	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL273982	98153	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	49850870	56359	0	None	-794	9	Human	7.0	pKi	=	7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631535	56359	0	None	-794	9	Human	7.0	pKi	=	7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	242	469	124	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	34	469	124	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	60795	469	124	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	CHEMBL1112	469	124	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	DB01238	469	124	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	135398737	955	93	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	38	955	93	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	722	955	93	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	CHEMBL42	955	93	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	DB00363	955	93	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	11407754	98153	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL273982	98153	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	44374234	55525	0	None	12	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1ccnc(-c2ccccc2)c1	10.1016/j.bmcl.2003.11.050
	CHEMBL162071	55525	0	None	12	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1ccnc(-c2ccccc2)c1	10.1016/j.bmcl.2003.11.050
	10737314	97242	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL268921	97242	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10737314	97242	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	CHEMBL268921	97242	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	11166042	166345	0	None	-2	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1021/jm049743b
	CHEMBL427518	166345	0	None	-2	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1021/jm049743b
	135	2515	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	1796	2515	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	4184	2515	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	CHEMBL6437	2515	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	DB06148	2515	43	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	CHEMBL5071978	214249	0	None	-1	6	Human	7.0	pKi	=	7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	127041874	137022	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	450	8	0	4	4.5	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	CHEMBL3746713	137022	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	450	8	0	4	4.5	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	145975905	163804	0	None	5	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	376	4	1	4	2.4	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4206366	163804	0	None	5	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	376	4	1	4	2.4	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	11414582	181314	0	None	-16	4	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4762886	181314	0	None	-16	4	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	2470	3626	50	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	3300	3626	50	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	5265	3626	50	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	99	3626	50	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	CHEMBL267930	3626	50	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	44439409	91187	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	5	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL240025	91187	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	5	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21	10.1016/j.bmcl.2007.01.093
	44439404	91756	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	334	3	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241103	91756	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	334	3	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	21509921	104431	0	None	-9	24	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104091	104431	0	None	-9	24	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	11808247	18043	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL126667	18043	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819366	18043	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	9888211	21384	13	None	-125	10	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	CHEMBL131495	21384	13	None	-125	10	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	10317515	99731	2	None	-19	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand	ChEMBL	378	3	0	4	1.8	O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1016/s0960-894x(03)00160-4
	CHEMBL285066	99731	2	None	-19	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand	ChEMBL	378	3	0	4	1.8	O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1016/s0960-894x(03)00160-4
	46204086	124529	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	CHEMBL3640562	124529	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	11327643	119556	0	None	1	2	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL346191	119556	0	None	1	2	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	240	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	2769	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	44279790	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	660	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL1729	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL560739	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	DB00604	941	43	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	135398745	2893	112	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	47	2893	112	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	CHEMBL715	2893	112	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	DB00334	2893	112	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	2337	3232	77	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	50	3232	77	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	5002	3232	77	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	CHEMBL716	3232	77	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	DB01224	3232	77	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	11327643	119556	0	None	-1	2	Rat	6.0	pKi	=	6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL346191	119556	0	None	-1	2	Rat	6.0	pKi	=	6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	9827938	11739	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181680	11739	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL188486	11739	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	46204086	124529	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	CHEMBL3640562	124529	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	10125797	161787	9	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL41436	161787	9	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL541621	161787	9	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	153287574	175223	0	None	-13	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4572167	175223	0	None	-13	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	146709966	175755	0	None	-338	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4583909	175755	0	None	-338	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	153287539	176050	0	None	-3	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591008	176050	0	None	-3	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	2543	3681	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	5358	3681	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	54	3681	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	CHEMBL128	3681	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	DB00669	3681	68	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	44439403	91755	0	None	-5	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	394	5	0	5	4.0	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL241102	91755	0	None	-5	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	394	5	0	5	4.0	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	76524414	140844	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819434	140844	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819713	140844	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	9913554	100965	0	None	-1258	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL29433	100965	0	None	-1258	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	46204732	124545	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640578	124545	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46204734	124548	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	CHEMBL3640580	124548	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	46205044	124553	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	CHEMBL3640585	124553	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	10668422	98137	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL273890	98137	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10643153	98495	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL276255	98495	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	46204732	124545	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640578	124545	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46204734	124548	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	CHEMBL3640580	124548	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	46205044	124553	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	CHEMBL3640585	124553	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	13149	2528	36	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
	3034396	2528	36	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL299031	2528	36	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
	11462900	56980	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	372	4	1	3	4.7	FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644270	56980	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	372	4	1	3	4.7	FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	53316608	56986	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	344	3	1	2	5.1	CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644276	56986	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	344	3	1	2	5.1	CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	53316609	56987	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644277	56987	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	11449570	56991	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	304	3	2	3	3.6	Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644281	56991	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	304	3	2	3	3.6	Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	3251	4041	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	5684	4041	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	80	4041	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	CHEMBL31354	4041	58	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	44368373	119532	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL345971	119532	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	10668422	98137	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1021/jm030841r
	CHEMBL273890	98137	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1021/jm030841r
	CHEMBL5282788	194149	0	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	422	7	0	5	3.5	O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2023.117256
	76524414	140844	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819434	140844	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819713	140844	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	118724647	120580	0	None	-5	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361004	120580	0	None	-5	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546104	120580	0	None	-5	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	11603887	102563	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
	CHEMBL2431046	102563	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
	CHEMBL3040877	102563	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
	90654670	110064	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	427	9	1	6	2.4	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235742	110064	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	427	9	1	6	2.4	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	136180321	117689	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401483	117689	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	11291892	133488	3	None	-24	3	Rat	7.0	pKi	=	7	Binding	In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
	CHEMBL370758	133488	3	None	-24	3	Rat	7.0	pKi	=	7	Binding	In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
	10994400	205098	0	None	-109	4	Human	7.0	pKi	=	7	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	439	5	1	2	4.4	OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	CHEMBL77855	205098	0	None	-109	4	Human	7.0	pKi	=	7	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	439	5	1	2	4.4	OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	2880253	162683	9	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	7	1	2	5.4	CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	CHEMBL4170813	162683	9	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	7	1	2	5.4	CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	71457409	82933	0	None	-3981	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	461	5	0	4	4.9	CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181168	82933	0	None	-3981	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	461	5	0	4	4.9	CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1	10.1021/jm300943r
	134147951	149780	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	5	0	3	3.4	COc1ccccc1-c1cc(CN(C)C)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3948597	149780	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	5	0	3	3.4	COc1ccccc1-c1cc(CN(C)C)ccc1OC	10.1016/j.ejmech.2016.07.029
	10737314	97242	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL268921	97242	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL5076882	214443	0	None	-26	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cccc(Cl)c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	CHEMBL5083505	214843	0	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00497
	1534	103013	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103013	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103013	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	10314060	168576	0	None	-72	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	322	4	1	4	2.9	COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	CHEMBL435949	168576	0	None	-72	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	322	4	1	4	2.9	COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	122442272	138323	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138323	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138323	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	18137015	164316	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212558	164316	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	23369457	189491	2	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	322	4	1	4	2.2	O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL514058	189491	2	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	322	4	1	4	2.2	O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	10754042	99772	0	None	2	4	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O	10.1021/jm9911433
	CHEMBL285352	99772	0	None	2	4	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O	10.1021/jm9911433
	1534	103013	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103013	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103013	53	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	134135372	144372	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	295	4	0	2	4.6	COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3906019	144372	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	295	4	0	2	4.6	COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1	10.1016/j.ejmech.2016.07.029
	168291659	192014	0	None	-14	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	356	8	3	8	1.4	Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5202120	192014	0	None	-14	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	356	8	3	8	1.4	Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	135414318	207762	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	298	0	1	5	3.1	CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1	10.1021/jm030030n
	CHEMBL96055	207762	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	298	0	1	5	3.1	CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1	10.1021/jm030030n
	145978146	163892	0	None	4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4207310	163892	0	None	4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	156013326	177470	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	4	1	4	3.8	COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4639400	177470	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	4	1	4	3.8	COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	124247485	164045	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	124247485	164045	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	2950739	162939	10	None	-4	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	4	4.6	COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4174845	162939	10	None	-4	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	4	4.6	COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1	10.1016/j.ejmech.2018.04.010
	57403525	70125	0	None	-691	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940402	70125	0	None	-691	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	21533446	70126	0	None	-281	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940403	70126	0	None	-281	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	122483264	138067	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763534	138067	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765840	138067	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	71726944	102377	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL3039669	102377	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL3215698	102377	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
	44388796	128034	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	415	5	0	4	4.8	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL366516	128034	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	415	5	0	4	4.8	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1	10.1016/j.bmcl.2005.05.059
	11131952	49324	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	353	8	1	5	3.4	O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL156385	49324	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	353	8	1	5	3.4	O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O	10.1021/jm020994z
	156016142	177724	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	506	8	0	6	5.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4642594	177724	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	506	8	0	6	5.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	155554326	174924	0	None	-13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	457	9	0	6	3.2	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4565558	174924	0	None	-13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	457	9	0	6	3.2	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	10638372	174362	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	306	4	0	2	3.0	O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL455210	174362	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	306	4	0	2	3.0	O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1	10.1021/jm8014553
	145946265	167490	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4203310	167490	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4299892	167490	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	122483264	138067	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763534	138067	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765840	138067	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	155536533	172162	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	444	7	1	5	4.8	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12	10.1016/j.ejmech.2019.111690
	CHEMBL4473636	172162	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	444	7	1	5	4.8	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12	10.1016/j.ejmech.2019.111690
	155547693	173547	0	None	-51	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	CHEMBL4532712	173547	0	None	-51	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	90654683	110077	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	452	8	1	4	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235755	110077	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	452	8	1	4	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	44437860	91207	0	None	-48	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	411	6	0	4	3.2	CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C	10.1016/j.bmc.2007.07.029
	CHEMBL240110	91207	0	None	-48	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	411	6	0	4	3.2	CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C	10.1016/j.bmc.2007.07.029
	53325849	56979	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644269	56979	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	54758201	65963	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	451	6	1	3	5.7	O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL1836782	65963	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	451	6	1	3	5.7	O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	60165413	75331	0	None	-31	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037531	75331	0	None	-31	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	168288780	191424	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	3.9	O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5193103	191424	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	3.9	O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	122483226	138081	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763504	138081	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765871	138081	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	122483226	138081	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763504	138081	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765871	138081	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	90654703	110062	0	None	26	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	399	7	1	6	1.6	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235740	110062	0	None	26	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	399	7	1	6	1.6	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	134147935	149665	0	None	18	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3947670	149665	0	None	18	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	154956306	179640	0	None	-12	6	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	435	6	0	6	4.5	Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4743324	179640	0	None	-12	6	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	435	6	0	6	4.5	Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O	10.1016/j.ejmech.2020.112709
	90656690	110958	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	7	2	4	2.8	OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262418	110958	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	7	2	4	2.8	OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	118728522	117691	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	390	8	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401485	117691	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	390	8	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	164616670	184589	0	None	-53	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4849077	184589	0	None	-53	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	11726532	96997	0	None	-141	4	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	0	5	3.5	COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	CHEMBL26677	96997	0	None	-141	4	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	0	5	3.5	COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	44460669	205580	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	283	4	0	3	2.9	C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81576	205580	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	283	4	0	3	2.9	C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	44460724	205597	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	339	4	0	4	4.0	CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81684	205597	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	339	4	0	4	4.0	CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	168289915	191530	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	553	11	4	8	4.9	Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5194614	191530	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	553	11	4	8	4.9	Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	60195992	81781	2	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	CHEMBL2164333	81781	2	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	10938620	204043	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	416	7	1	3	5.2	COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	CHEMBL70048	204043	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	416	7	1	3	5.2	COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	155538236	172347	0	None	-40	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	496	7	1	5	5.2	O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4476164	172347	0	None	-40	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	496	7	1	5	5.2	O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	155515920	176660	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4442332	176660	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4598348	176660	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
	46203754	124519	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	CHEMBL3640553	124519	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	10024070	67159	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	402	8	0	4	3.5	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	CHEMBL187764	67159	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	402	8	0	4	3.5	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	46203754	124519	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	CHEMBL3640553	124519	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	71458652	81406	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	5	3.0	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159478	81406	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	5	3.0	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2012.07.043
	118731353	118086	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	524	10	1	4	4.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3407516	118086	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	524	10	1	4	4.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	145980458	166693	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	476	6	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4282860	166693	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	476	6	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	155526720	171186	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4459410	171186	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1	10.1016/j.bmcl.2019.126703
	155552707	174024	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	1	3	5.5	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4543789	174024	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	1	3	5.5	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1	10.1016/j.bmcl.2019.126703
	2726	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	621	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	83	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	CHEMBL71	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	DB00477	916	68	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	54758204	65965	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836784	65965	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	11393666	192962	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5201983	192962	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5222597	192962	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	42618267	182799	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL479105	182799	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.008
	11683077	65972	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	414	6	1	2	5.7	O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	CHEMBL1836791	65972	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	414	6	1	2	5.7	O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	71061887	93089	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442996	93089	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061887	93089	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442996	93089	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	44266284	97315	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	377	5	0	3	5.1	Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL269400	97315	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	377	5	0	3	5.1	Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	22273749	208164	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	4	0	3	4.7	COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9840	208164	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	4	0	3	4.7	COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1	10.1016/s0960-894x(03)00077-5
	135398737	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	38	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	722	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	CHEMBL42	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	DB00363	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	11191128	85181	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/acs.jmedchem.5b00982
	CHEMBL225512	85181	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/acs.jmedchem.5b00982
	11191128	85181	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL225512	85181	0	None	2	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	134137732	147744	0	None	11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3932551	147744	0	None	11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	179	399	115	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	2159	399	115	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	963	399	115	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	CHEMBL243712	399	115	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	DB06288	399	115	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	90656711	110941	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262393	110941	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	90656711	110941	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262393	110941	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	118713683	114361	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	6	4.0	COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331386	114361	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	6	4.0	COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	44266245	167193	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	398	5	0	3	4.3	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL429202	167193	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	398	5	0	3	4.3	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/s0960-894x(03)00077-5
	136180320	117688	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401482	117688	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	164622487	186098	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	339	4	0	4	2.8	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4871850	186098	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	339	4	0	4	2.8	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	2470	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL5071978	214249	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	145976686	163898	0	None	24	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207365	163898	0	None	24	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	56944861	157050	0	None	-42	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4074195	157050	0	None	-42	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	2470	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	2470	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	3300	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	5265	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	99	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	CHEMBL267930	3626	50	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	11207101	75915	1	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	CHEMBL2051975	75915	1	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	9818448	127454	1	None	-17	3	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	318	4	1	2	4.5	COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1	10.1021/jm049743b
	CHEMBL366081	127454	1	None	-17	3	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	318	4	1	2	4.5	COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1	10.1021/jm049743b
	1353	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	3559	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	86	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	CHEMBL54	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	DB00502	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	198914	146678	8	None	79	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	264	1	3	2	3.1	Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL392401	146678	8	None	79	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	264	1	3	2	3.1	Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	71460455	81337	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159314	81337	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1	10.1016/j.ejmech.2012.07.043
	71462156	81342	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	445	6	1	4	5.1	O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159319	81342	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	445	6	1	4	5.1	O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	90654673	110067	0	None	-54	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	494	10	1	5	3.9	CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235745	110067	0	None	-54	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	494	10	1	5	3.9	CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	11154555	797	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	5037	797	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	7671	797	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	CHEMBL2028019	797	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	CHEMBL3085826	797	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	DB06016	797	62	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	118736376	118922	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	531	7	0	9	3.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423340	118922	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	531	7	0	9	3.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2015.04.046
	127052487	140775	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818805	140775	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	90656681	110953	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	327	6	0	3	3.5	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262413	110953	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	327	6	0	3	3.5	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2014.04.034
	155561995	175698	0	None	-36	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	532	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4582567	175698	0	None	-36	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	532	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	155522218	170613	0	None	-51	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	492	7	1	5	5.3	O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	CHEMBL4451231	170613	0	None	-51	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	492	7	1	5	5.3	O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	145983018	165493	0	None	-125	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240910	165493	0	None	-125	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	46204083	124525	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640559	124525	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	46204083	124525	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640559	124525	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	118724648	116439	0	None	-5	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	515	7	0	10	1.5	Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361005	116439	0	None	-5	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	515	7	0	10	1.5	Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	127052487	140775	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818805	140775	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	49756	204289	13	None	-14	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030826m
	CHEMBL7143	204289	13	None	-14	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030826m
	1353	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	3559	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	86	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	CHEMBL54	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	DB00502	1898	93	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	134154108	152596	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	309	4	0	2	4.9	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3972166	152596	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	309	4	0	2	4.9	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	90654701	110060	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	426	7	1	4	2.8	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235738	110060	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	426	7	1	4	2.8	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	57398619	71537	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949962	71537	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963099	71537	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	136180318	117686	0	None	-14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401480	117686	0	None	-14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	46204089	124532	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	CHEMBL3640565	124532	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	46204089	124532	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	CHEMBL3640565	124532	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	44286416	141393	0	None	-11	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	448	8	0	6	4.3	O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL38409	141393	0	None	-11	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	448	8	0	6	4.3	O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	156014787	177521	0	None	3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	428	6	1	5	3.6	COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640281	177521	0	None	3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	428	6	1	5	3.6	COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	15443	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL340211	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	15443	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL340211	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	162673483	183748	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4796251	183748	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803945	183748	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	71458622	81329	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	376	7	1	5	3.7	CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159306	81329	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	376	7	1	5	3.7	CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	71727068	91238	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401934	91238	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401938	91238	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	155510928	176445	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4435010	176445	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4596543	176445	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	13069623	120583	0	None	-50	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360994	120583	0	None	-50	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546108	120583	0	None	-50	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	44456400	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	10317139	67046	0	None	-758	2	Rat	4.9	pKi	=	4.9	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	371	4	0	5	2.3	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL187270	67046	0	None	-758	2	Rat	4.9	pKi	=	4.9	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	371	4	0	5	2.3	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	145973438	164499	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4214853	164499	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	145971588	164529	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4215182	164529	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	155539483	172838	0	None	-162	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	504	7	2	3	5.4	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	CHEMBL4515160	172838	0	None	-162	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	504	7	2	3	5.4	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	44456400	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12802	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	122181336	121852	0	None	-8	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	432	6	1	4	3.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590088	121852	0	None	-8	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	432	6	1	4	3.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	118731347	118158	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	4	3.4	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409031	118158	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	4	3.4	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	44455426	155125	0	None	-1	12	Human	6.9	pKi	=	6.9	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL402143	155125	0	None	-1	12	Human	6.9	pKi	=	6.9	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	72198191	89791	0	None	-144	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	5	2	3	4.5	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377445	89791	0	None	-144	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	5	2	3	4.5	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	46205373	124561	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	CHEMBL3640593	124561	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	46205373	124561	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	CHEMBL3640593	124561	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	122181339	121855	0	None	-22	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	500	6	1	4	4.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590091	121855	0	None	-22	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	500	6	1	4	4.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	156013203	177458	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.7	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4639203	177458	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.7	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2020.115459
	156021656	178163	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649308	178163	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1	10.1016/j.bmc.2019.115262
	162647097	179695	0	None	-125	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4744007	179695	0	None	-125	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	156020908	178007	0	None	-2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	0	6	5.4	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4646868	178007	0	None	-2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	0	6	5.4	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	54758298	65978	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL1836857	65978	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	11207101	75915	1	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	CHEMBL2051975	75915	1	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	44263956	204425	1	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	232	4	0	3	2.3	COc1ccc2c(c1)c(CCN(C)C)cn2C	10.1021/jm049743b
	CHEMBL7220	204425	1	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	232	4	0	3	2.3	COc1ccc2c(c1)c(CCN(C)C)cn2C	10.1021/jm049743b
	90654700	110059	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235737	110059	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	71454899	81131	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	5	4.3	CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158026	81131	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	5	4.3	CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1	10.1016/j.ejmech.2012.07.043
	155526651	171150	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	464	8	0	4	5.7	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4458938	171150	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	464	8	0	4	5.7	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1	10.1016/j.bmcl.2019.06.029
	155540823	172516	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	456	7	0	5	3.6	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4483779	172516	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	456	7	0	5	3.6	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	2726	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	621	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	83	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	CHEMBL71	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	DB00477	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	11409589	85101	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL224883	85101	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	127029649	138147	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	462	6	2	5	2.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3769536	138147	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	462	6	2	5	2.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	126720403	162586	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	4	1	5	3.2	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4169236	162586	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	4	1	5	3.2	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	155542321	173101	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	CHEMBL4520796	173101	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	155542321	173101	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2022.114645
	CHEMBL4520796	173101	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2022.114645
	90654685	110079	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	522	5	1	4	4.4	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235757	110079	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	522	5	1	4	4.4	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.ejmech.2014.03.005
	162670959	183730	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4791316	183730	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803791	183730	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	90654694	110053	0	None	-27	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	402	9	1	5	1.9	COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235731	110053	0	None	-27	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	402	9	1	5	1.9	COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	10947658	28671	0	None	-10	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL137781	28671	0	None	-10	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	46214153	110668	0	None	3	5	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	CHEMBL3260334	110668	0	None	3	5	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	44374299	119511	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmcl.2003.11.050
	CHEMBL345803	119511	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmcl.2003.11.050
	11603514	71461	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926760	71461	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962492	71461	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	127026450	137732	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759281	137732	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	145985233	165499	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241050	165499	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	145984737	165555	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242392	165555	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	145985527	165685	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245622	165685	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	145985823	165900	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4250475	165900	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	134153716	152460	0	None	9	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3971125	152460	0	None	9	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	71453252	81332	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159309	81332	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	71453282	81419	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159491	81419	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	71574210	86254	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312934	86254	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	118731351	118162	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	118162	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731365	118175	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	592	10	0	4	6.4	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409048	118175	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	592	10	0	4	6.4	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	145947977	167691	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4162279	167691	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4302540	167691	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	23642275	481	31	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
	8433	481	31	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
	CHEMBL2164327	481	31	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
	71453252	81332	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1039/C5MD00166H
	CHEMBL2159309	81332	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1039/C5MD00166H
	142601335	186397	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	66803497	158487	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4091193	158487	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	145964944	164057	0	None	-14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	391	4	0	4	5.0	Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	CHEMBL4209430	164057	0	None	-14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	391	4	0	4	5.0	Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	10862787	103010	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1016/j.bmc.2019.06.028
	CHEMBL307101	103010	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1016/j.bmc.2019.06.028
	90656696	110971	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	367	9	1	4	4.2	CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262430	110971	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	367	9	1	4	4.2	CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	44374299	119511	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmc.2010.01.035
	CHEMBL345803	119511	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmc.2010.01.035
	127051844	140822	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140822	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	145988193	167055	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4289605	167055	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	90656672	110965	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	451	8	1	5	3.8	O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262425	110965	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	451	8	1	5	3.8	O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	155565215	175586	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	433	6	1	7	3.5	Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	CHEMBL4580230	175586	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	433	6	1	7	3.5	Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	10862787	103010	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1021/jm0104264
	CHEMBL307101	103010	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1021/jm0104264
	11826723	204220	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	464	6	1	2	5.9	O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL71057	204220	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	464	6	1	2	5.9	O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	142601335	186397	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127051844	140822	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140822	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	72734860	103930	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092753	103930	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	44456395	95642	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
	CHEMBL258073	95642	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
	11302161	67248	0	None	-8	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	CHEMBL188176	67248	0	None	-8	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	44319240	106883	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	374	6	1	2	4.8	O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL314672	106883	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	374	6	1	2	4.8	O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	135398737	955	93	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	38	955	93	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	722	955	93	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	CHEMBL42	955	93	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	DB00363	955	93	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	6540428	184840	1	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL3989558	184840	1	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL485253	184840	1	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
	10571274	99431	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL283065	99431	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	135398737	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	38	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	722	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	CHEMBL42	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	DB00363	955	93	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	6540428	184840	1	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
	CHEMBL3989558	184840	1	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
	CHEMBL485253	184840	1	None	-19	3	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
	11151958	66941	0	None	-9	3	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	CHEMBL186758	66941	0	None	-9	3	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	71062123	93088	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442995	93088	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71062123	93088	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442995	93088	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	76284453	104979	0	None	67	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	476	10	1	5	4.0	Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1	10.1016/j.bmc.2014.01.016
	CHEMBL3113595	104979	0	None	67	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	476	10	1	5	4.0	Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1	10.1016/j.bmc.2014.01.016
	90656713	110942	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	385	4	2	3	4.7	Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262394	110942	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	385	4	2	3	4.7	Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	162662399	181905	0	None	-12	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4779739	181905	0	None	-12	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	11948707	166143	0	None	-158	13	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1021/acs.jmedchem.2c00633
	CHEMBL426317	166143	0	None	-158	13	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1021/acs.jmedchem.2c00633
	21830793	91806	10	None	-85	46	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	CHEMBL2413154	91806	10	None	-85	46	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	118728524	117693	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401487	117693	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2015.02.042
	145990586	166819	0	None	-9	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	CHEMBL4285281	166819	0	None	-9	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	66801425	157162	0	None	-39	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	441	8	2	3	4.5	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4075673	157162	0	None	-39	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	441	8	2	3	4.5	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	66801354	112056	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	450	7	1	6	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289977	112056	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	450	7	1	6	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	44437329	151576	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396349	151576	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	46205700	124367	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3639394	124367	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46204088	124531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640564	124531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46205697	124566	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640598	124566	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46206344	124581	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	CHEMBL3640612	124581	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	46205700	124367	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3639394	124367	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46204088	124531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640564	124531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46205697	124566	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640598	124566	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46206344	124581	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	CHEMBL3640612	124581	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	162662361	181448	0	None	-20	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4764557	181448	0	None	-20	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	2726	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	621	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	83	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	CHEMBL71	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	DB00477	916	68	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	15443	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL340211	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	15443	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL340211	117784	96	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	44374206	52527	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	248	5	1	4	2.1	CN(C)CCSc1n[nH]c(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL159223	52527	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	248	5	1	4	2.1	CN(C)CCSc1n[nH]c(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	60364	106367	10	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3121413	106367	10	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3139439	106367	10	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
	21557475	174865	0	None	-6	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	442	8	0	5	4.2	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4564093	174865	0	None	-6	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	442	8	0	5	4.2	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	71602639	89652	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376449	89652	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	23661735	90959	0	None	-467	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	423	3	0	4	3.7	O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239681	90959	0	None	-467	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	423	3	0	4	3.7	O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	145946271	167493	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4162548	167493	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4299919	167493	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145965840	163992	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	425	5	1	4	3.8	O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4208468	163992	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	425	5	1	4	3.8	O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	71449642	81404	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	7	1	5	2.8	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159476	81404	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	7	1	5	2.8	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	90654842	112617	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233670	112617	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302936	112617	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
	118736374	118920	0	None	-13	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	559	8	0	9	4.0	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423338	118920	0	None	-13	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	559	8	0	9	4.0	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	11328878	136905	0	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	469	9	1	4	5.2	COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL374261	136905	0	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	469	9	1	4	5.2	COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	136118614	93035	0	None	-13	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442276	93035	0	None	-13	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	2843443	117906	18	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	380	2	0	2	5.3	Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403336	117906	18	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	380	2	0	2	5.3	Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1	10.1016/j.bmcl.2015.03.049
	56850924	71493	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926758	71493	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962806	71493	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	90654850	112619	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233674	112619	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302943	112619	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	156015194	177529	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	377	4	2	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640332	177529	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	377	4	2	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	10313351	10231	23	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1cccc2c1C[C@H](N)CC2	10.1021/jm030826m
	CHEMBL1161324	10231	23	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1cccc2c1C[C@H](N)CC2	10.1021/jm030826m
	42618253	181283	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	5	0	5	3.6	O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476248	181283	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	5	0	5	3.6	O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1	10.1016/j.bmcl.2009.02.008
	135367869	164710	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4217548	164710	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	9419	35892	35	None	-616	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
	CHEMBL1442422	35892	35	None	-616	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
	126720440	163002	0	None	-2041	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	339	4	1	5	2.6	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4175829	163002	0	None	-2041	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	339	4	1	5	2.6	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	71574300	86257	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312937	86257	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	155554325	176497	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4548353	176497	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4597000	176497	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	118736367	118913	0	None	-10	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	479	7	1	10	1.7	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423331	118913	0	None	-10	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	479	7	1	10	1.7	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	15599151	173915	0	None	-1621	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4541086	173915	0	None	-1621	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.8b01662
	135367869	164710	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4217548	164710	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	164614828	185245	0	None	-186	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4858771	185245	0	None	-186	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	44268087	20162	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	CHEMBL13049	20162	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	44460641	105823	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	271	3	0	3	2.6	Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL312720	105823	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	271	3	0	3	2.6	Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	53370045	166409	7	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	376	6	2	6	0.5	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1	10.1039/C8MD00168E
	CHEMBL4277406	166409	7	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	376	6	2	6	0.5	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1	10.1039/C8MD00168E
	164614734	185372	0	None	-41	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	443	8	0	6	2.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4860754	185372	0	None	-41	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	443	8	0	6	2.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	155546595	173519	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	586	10	1	6	5.8	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4531761	173519	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	586	10	1	6	5.8	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	44424662	85751	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	488	9	0	9	2.5	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229366	85751	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	488	9	0	9	2.5	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	11421024	84665	0	None	30	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222603	84665	0	None	30	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	1346	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	280	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	9899402	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	CHEMBL9666	83	117	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	49850772	56369	0	None	-794	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631545	56369	0	None	-794	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	10619437	16540	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	CHEMBL12389	16540	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	10619437	16540	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL12389	16540	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	44368683	45521	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL152873	45521	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	134156222	154327	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	CHEMBL3986927	154327	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	CHEMBL5073337	214269	0	None	-30	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	CHEMBL5093017	215378	0	None	-35	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc(F)c(Cl)c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	162657622	181113	0	None	-48	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4760655	181113	0	None	-48	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	277	1289	62	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	2913	1289	62	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	765	1289	62	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL516	1289	62	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	DB00434	1289	62	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	11248705	90266	0	None	-50	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238519	90266	0	None	-50	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	11178830	148102	0	None	-79	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL393539	148102	0	None	-79	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	122483276	138088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763677	138088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765878	138088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	60167451	75319	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037520	75319	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	145971527	163093	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	337	7	1	2	5.6	Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4177293	163093	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	337	7	1	2	5.6	Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	57393878	68403	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917353	68403	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	164610188	185031	0	None	-194	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4855393	185031	0	None	-194	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	1574	81	60	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
	218	81	60	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
	CHEMBL266591	81	60	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
	11191906	11735	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181665	11735	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL187928	11735	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	71602639	89652	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376449	89652	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	155519891	170369	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4447975	170369	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	153287568	170961	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4456195	170961	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	1524	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	197	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	3822	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	88	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	CHEMBL51	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	DB12465	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	52952420	62561	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	377	5	1	5	4.0	N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782808	62561	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	377	5	1	5	4.0	N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	17374371	117900	9	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	447	5	1	5	4.7	O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403330	117900	9	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	447	5	1	5	4.7	O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1	10.1016/j.bmcl.2015.03.049
	57399868	71527	0	None	39	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949978	71527	0	None	39	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963032	71527	0	None	39	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	134140472	145996	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	0	2	3.4	COc1ccccc1-c1cccc(CN(C)C)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3918663	145996	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	0	2	3.4	COc1ccccc1-c1cccc(CN(C)C)c1	10.1016/j.ejmech.2016.07.029
	49756	204289	13	None	-5	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030030n
	CHEMBL7143	204289	13	None	-5	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030030n
	46204731	124544	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640577	124544	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	46204731	124544	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640577	124544	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	134156222	154327	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	CHEMBL3986927	154327	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	122483276	138088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763677	138088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765878	138088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	60167451	75319	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037520	75319	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	60167451	75319	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037520	75319	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	22425072	117914	7	None	-1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	457	5	0	4	6.5	Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403343	117914	7	None	-1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	457	5	0	4	6.5	Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2015.03.049
	122442272	138323	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138323	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138323	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	137646281	157782	0	None	-295	17	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4083252	157782	0	None	-295	17	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	46233350	200277	0	None	7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	286	5	0	3	4.0	Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	CHEMBL597357	200277	0	None	7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	286	5	0	3	4.0	Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	4723431	171399	14	None	-14	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	316	6	2	2	4.8	c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4462814	171399	14	None	-14	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	316	6	2	2	4.8	c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	122483231	138062	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765208	138062	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765835	138062	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	122483231	138062	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765208	138062	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765835	138062	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	11443608	143705	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	CHEMBL390062	143705	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	46205695	124564	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	CHEMBL3640596	124564	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	46206025	124579	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	CHEMBL3640610	124579	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	46205695	124564	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	CHEMBL3640596	124564	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	46206025	124579	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	CHEMBL3640610	124579	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	44393021	65020	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182356	65020	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	154926540	190300	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	439	10	1	4	4.6	CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	CHEMBL5176380	190300	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	439	10	1	4	4.6	CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	54764323	68409	0	None	85	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917359	68409	0	None	85	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	127040908	137048	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747071	137048	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	71449641	81385	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	9	1	4	4.6	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159458	81385	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	9	1	4	4.6	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	60196073	81786	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	CHEMBL2164339	81786	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	10571274	99431	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL283065	99431	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	44408816	76549	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	8	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206305	76549	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	8	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	54758392	65975	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	398	6	1	2	5.5	O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	CHEMBL1836794	65975	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	398	6	1	2	5.5	O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	66801000	112035	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	472	7	1	7	4.0	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289957	112035	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	472	7	1	7	4.0	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	56944473	112101	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	8	1	7	4.5	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3290021	112101	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	8	1	7	4.5	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	9839050	112352	0	None	-26	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
	CHEMBL329566	112352	0	None	-26	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
	162664534	182078	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	418	9	0	6	4.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4781863	182078	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	418	9	0	6	4.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	90656691	110961	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	7	1	4	3.1	O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262421	110961	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	7	1	4	3.1	O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	135458394	97663	5	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	CHEMBL271298	97663	5	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	11173572	129881	0	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	CHEMBL367584	129881	0	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	10706626	99105	0	None	1	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm030030n
	CHEMBL281048	99105	0	None	1	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm030030n
	10706626	99105	0	None	-1	6	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm9911433
	CHEMBL281048	99105	0	None	-1	6	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm9911433
	11173572	129881	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmc.2010.01.035
	CHEMBL367584	129881	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmc.2010.01.035
	46203760	124523	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640557	124523	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	46203760	124523	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640557	124523	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	10730269	97074	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O	10.1021/jm9911433
	CHEMBL26751	97074	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O	10.1021/jm9911433
	135895192	172187	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	418	6	1	5	4.3	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4473885	172187	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	418	6	1	5	4.3	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	122181341	121857	0	None	-42	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590093	121857	0	None	-42	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	162672061	183739	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4793191	183739	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803857	183739	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	44424654	85725	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	460	7	0	9	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229123	85725	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	460	7	0	9	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	9867475	17981	0	None	-426	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL126340	17981	0	None	-426	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	2870750	117904	7	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	442	4	1	5	6.0	Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403334	117904	7	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	442	4	1	5	6.0	Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12	10.1016/j.bmcl.2015.03.049
	122483238	138079	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763567	138079	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765853	138079	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	24768524	93173	0	None	-4	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL244577	93173	0	None	-4	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	13069627	120587	0	None	-26	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361001	120587	0	None	-26	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546113	120587	0	None	-26	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	134136246	142513	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3890841	142513	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	162663078	181970	0	None	-46	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4780470	181970	0	None	-46	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	134130594	142219	0	None	-7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884728	142219	0	None	-7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	16763549	117915	9	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	342	5	1	5	2.8	COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N	10.1016/j.bmcl.2015.03.049
	CHEMBL3403344	117915	9	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	342	5	1	5	2.8	COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N	10.1016/j.bmcl.2015.03.049
	90654697	110056	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235734	110056	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	122483238	138079	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763567	138079	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765853	138079	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	57397410	68393	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917343	68393	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	134136246	142513	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3890841	142513	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	156010584	177055	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633042	177055	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	56649648	67826	0	None	-398	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910139	67826	0	None	-398	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	10780842	97876	0	None	-1	5	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL27247	97876	0	None	-1	5	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	134131151	142211	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	9	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884634	142211	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	9	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	155538877	172769	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	382	7	1	5	3.1	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4513482	172769	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	382	7	1	5	3.1	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	1524	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	197	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	3822	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	88	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	CHEMBL51	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	DB12465	2168	96	None	-501	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	164618028	185319	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4859988	185319	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	42618270	91169	0	None	-22	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.8	O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239897	91169	0	None	-22	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.8	O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	164618028	185319	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4859988	185319	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	162671033	183731	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4793296	183731	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4803797	183731	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	145985958	165586	0	None	-112	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243036	165586	0	None	-112	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	18137017	163504	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4202769	163504	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	164624246	185919	0	None	-158	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4869411	185919	0	None	-158	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	10042333	163450	1	None	-831	3	Human	5.9	pKi	=	5.9	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	331	5	1	2	4.0	OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	CHEMBL420010	163450	1	None	-831	3	Human	5.9	pKi	=	5.9	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	331	5	1	2	4.0	OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	118731355	118165	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	10	0	5	3.7	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409038	118165	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	10	0	5	3.7	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1	10.1016/j.ejmech.2014.12.041
	90654844	112597	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233671	112597	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302598	112597	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
	71727067	91237	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401937	91237	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL3217036	91237	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	155524491	170932	0	None	-169	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4455658	170932	0	None	-169	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	71458648	81386	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	4	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159459	81386	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	4	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	118736364	118910	0	None	-676	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	451	6	1	10	1.0	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423328	118910	0	None	-676	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	451	6	1	10	1.0	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	90656706	112583	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262436	112583	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302236	112583	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	155516118	170015	3	None	-549	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	351	6	3	4	4.0	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4442855	170015	3	None	-549	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	351	6	3	4	4.0	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	134131015	142280	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	CHEMBL3885282	142280	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	155569396	176114	0	None	10	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	279	2	1	2	4.1	CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4592256	176114	0	None	10	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	279	2	1	2	4.1	CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	134144304	154469	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3952251	154469	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3990525	154469	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	168281650	191178	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5189417	191178	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	155533850	171868	0	None	-45	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4469633	171868	0	None	-45	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	44460701	205242	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	302	4	0	5	2.2	CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL78977	205242	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	302	4	0	5	2.2	CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1	10.1016/s0960-894x(02)00438-9
	54758294	65968	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836787	65968	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	44424667	85694	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	398	5	1	8	-0.1	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL228938	85694	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	398	5	1	8	-0.1	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	122483254	138071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764307	138071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765844	138071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	10472143	119251	0	None	-31	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL343755	119251	0	None	-31	16	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	53324535	56977	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	323	3	1	3	3.9	Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644267	56977	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	323	3	1	3	3.9	Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	242	469	124	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	34	469	124	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	60795	469	124	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	CHEMBL1112	469	124	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	DB01238	469	124	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	44461070	205614	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	4	0	3	3.8	CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81784	205614	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	4	0	3	3.8	CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	137642134	158317	0	None	10	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4089427	158317	0	None	10	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	127028473	138248	0	None	22	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770639	138248	0	None	22	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	127026451	137738	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759342	137738	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	127026752	137770	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759577	137770	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1	10.1016/j.ejmech.2015.11.040
	127026133	137796	0	None	6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	5.4	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759819	137796	0	None	6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	5.4	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	145983128	165801	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248597	165801	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	134155645	151049	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3958956	151049	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	71458650	81402	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159474	81402	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	155566925	175840	0	None	56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	293	1	1	2	3.5	Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4585956	175840	0	None	56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	293	1	1	2	3.5	Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	66801295	157117	0	None	-8	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4075144	157117	0	None	-8	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	164621610	186167	0	None	2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4872800	186167	0	None	2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	118706282	120504	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310111	120504	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545465	120504	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	66801246	112099	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	7	3.6	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3290019	112099	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	7	3.6	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	118713681	114359	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	379	8	0	5	4.0	O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331384	114359	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	379	8	0	5	4.0	O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	44266203	98379	0	None	19	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	389	4	0	5	3.2	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275475	98379	0	None	19	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	389	4	0	5	3.2	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	164621610	186167	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4872800	186167	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	134157769	154035	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	2	6	4.7	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3984541	154035	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	2	6	4.7	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	162676611	183450	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	501	9	1	6	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4799274	183450	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	501	9	1	6	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	164614709	185185	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4857665	185185	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	69729	169649	73	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	180	4	0	1	3.2	CCCCC(=O)c1ccc(F)cc1	10.1021/jm030030n
	CHEMBL443757	169649	73	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	180	4	0	1	3.2	CCCCC(=O)c1ccc(F)cc1	10.1021/jm030030n
	45272891	195892	0	None	72	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	459	9	3	5	2.4	COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL559260	195892	0	None	72	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	459	9	3	5	2.4	COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2009.06.038
	44460642	205724	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	281	3	0	3	2.3	C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL82708	205724	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	281	3	0	3	2.3	C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	24873261	183170	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4795756	183170	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	56944860	158983	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	CHEMBL4096479	158983	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	155520553	176485	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4449590	176485	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596888	176485	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	599482	202961	9	None	-10	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
	CHEMBL6310	202961	9	None	-10	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
	11282743	84605	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL222275	84605	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	42	2050	57	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
	56971	2050	57	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
	CHEMBL8412	2050	57	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
	135367403	164221	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4211303	164221	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	127029650	138241	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770581	138241	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	162672312	183742	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4795807	183742	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803872	183742	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	2921525	54840	14	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL1379600	54840	14	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL1613157	54840	14	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
	10478367	71641	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	CHEMBL196370	71641	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	CHEMBL430500	71641	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	164623862	185981	0	None	-79	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	CHEMBL4870361	185981	0	None	-79	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	122483254	138071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764307	138071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765844	138071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	135367403	164221	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4211303	164221	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	52952099	62553	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	365	5	1	5	3.9	Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782796	62553	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	365	5	1	5	3.9	Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	18137020	163905	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	360	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207433	163905	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	360	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	137637994	155918	0	None	2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4061131	155918	0	None	2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	118626120	165765	0	None	-23	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4247770	165765	0	None	-23	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	57400829	68402	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	6	1	4	3.4	O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917352	68402	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	6	1	4	3.4	O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	11256720	2042	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	9444	2042	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	CHEMBL1083390	2042	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	DB12680	2042	79	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	46233383	198878	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	285	5	0	2	4.6	Cc1cccc(C)c1-c1ccccc1SCCN(C)C	10.1016/j.bmc.2010.01.035
	CHEMBL584429	198878	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	285	5	0	2	4.6	Cc1cccc(C)c1-c1ccccc1SCCN(C)C	10.1016/j.bmc.2010.01.035
	13069624	120575	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360991	120575	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3545931	120575	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	134130447	142282	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	9	0	5	4.5	c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1	10.1016/j.bmc.2016.12.039
	CHEMBL3885319	142282	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	9	0	5	4.5	c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1	10.1016/j.bmc.2016.12.039
	118728526	117695	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401489	117695	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	135367917	163571	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4203526	163571	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	71458649	81401	0	None	-5	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	370	7	1	5	2.3	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159473	81401	0	None	-5	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	370	7	1	5	2.3	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	134153539	154481	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3971383	154481	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990611	154481	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	72734865	106288	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3092756	106288	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3139103	106288	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	134153539	154481	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3971383	154481	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990611	154481	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	155528967	171368	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	510	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	CHEMBL4462139	171368	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	510	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	155546350	173523	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4531898	173523	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12	10.1016/j.ejmech.2019.03.017
	135367917	163571	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4203526	163571	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	168288545	191739	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	372	8	3	9	1.1	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5197737	191739	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	372	8	3	9	1.1	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	44460918	205767	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	299	4	0	3	3.4	CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL83090	205767	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	299	4	0	3	3.4	CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	49756	204289	13	None	-5	8	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
	CHEMBL7143	204289	13	None	-5	8	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
	136180316	117684	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	362	6	1	4	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401478	117684	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	362	6	1	4	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	57399866	71512	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949974	71512	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1962960	71512	0	None	3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	156018141	177897	0	None	-36	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	439	9	0	5	3.4	COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4645292	177897	0	None	-36	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	439	9	0	5	3.4	COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1	10.1016/j.bmc.2020.115459
	44352308	117461	0	None	-177	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	CHEMBL339980	117461	0	None	-177	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	118728514	117683	0	None	-27	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401477	117683	0	None	-27	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	118728511	117680	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	8	1	5	3.8	Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401474	117680	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	8	1	5	3.8	Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1	10.1016/j.bmcl.2015.02.042
	162671033	183731	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4793296	183731	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4803797	183731	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	11112531	102150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL302723	102150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	11112531	102150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL302723	102150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	142601318	185521	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185521	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	2853434	117905	15	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	386	3	1	2	4.9	O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403335	117905	15	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	386	3	1	2	4.9	O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	134145143	150710	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	4	1	4	2.8	CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3956286	150710	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	4	1	4	2.8	CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2	10.1016/j.ejmech.2016.07.029
	11132982	51878	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL158592	51878	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O	10.1021/jm020994z
	90654674	110068	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	500	6	1	5	3.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235746	110068	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	500	6	1	5	3.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	164619075	186159	0	None	-9	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	413	7	0	5	2.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4872713	186159	0	None	-9	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	413	7	0	5	2.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
	142601318	185521	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185521	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	25107581	192607	0	None	-14	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	CHEMBL521687	192607	0	None	-14	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	10378785	16738	0	None	-5	4	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL124419	16738	0	None	-5	4	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	46206345	124582	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	CHEMBL3640613	124582	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	46206345	124582	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	CHEMBL3640613	124582	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	46233449	201969	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	287	6	0	5	2.3	COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1	10.1016/j.bmc.2010.01.035
	CHEMBL608138	201969	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	287	6	0	5	2.3	COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1	10.1016/j.bmc.2010.01.035
	164618510	185909	0	None	-8	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	4.1	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4869198	185909	0	None	-8	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	4.1	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	49862237	14975	0	None	6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	CHEMBL1209157	14975	0	None	6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	11783562	54372	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	CHEMBL160906	54372	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	5074	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	97	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	CHEMBL267777	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	DB12693	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	72711488	102558	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
	CHEMBL2431041	102558	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
	CHEMBL3040835	102558	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
	76332577	106251	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121419	106251	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139022	106251	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	71451458	81414	0	None	-3	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	5	3.5	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159486	81414	0	None	-3	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	5	3.5	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	118731358	118168	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	530	10	0	4	5.4	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409041	118168	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	530	10	0	4	5.4	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	25107716	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	8436	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	CHEMBL522691	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	11393128	182837	0	None	-7	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4791646	182837	0	None	-7	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	25107716	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
	8436	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL522691	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
	66801344	159398	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4100951	159398	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	122178699	121340	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL3581245	121340	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	164614709	185185	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4857665	185185	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	164622973	186099	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4871868	186099	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	25107716	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	8436	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	CHEMBL522691	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	44408630	139283	0	None	100	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	376	7	0	5	3.9	CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL379238	139283	0	None	100	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	376	7	0	5	3.9	CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	71678857	147246	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3928716	147246	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.ejmech.2016.07.029
	92042877	149151	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	149151	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	25107716	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
	8436	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
	CHEMBL522691	2336	43	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
	56944287	112077	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	9	1	6	4.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289998	112077	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	9	1	6	4.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	122178699	121340	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581245	121340	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	145946966	167573	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4209888	167573	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300899	167573	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	164622973	186099	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4871868	186099	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	162670302	182709	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	419	8	1	6	3.8	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4789865	182709	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	419	8	1	6	3.8	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	71062035	93087	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442994	93087	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71062035	93087	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442994	93087	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	11785183	84684	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	CHEMBL222755	84684	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	11785183	84684	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84684	0	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	135458392	97397	5	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	CHEMBL269964	97397	5	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	46204728	124542	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640575	124542	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	46204728	124542	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640575	124542	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL5084167	214876	0	None	-63	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.1c00497
	134137560	142680	0	None	6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3892201	142680	0	None	6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	162673308	183085	0	None	25	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	443	8	1	6	3.8	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4794688	183085	0	None	25	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	443	8	1	6	3.8	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	18377409	206024	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	1	3	4.0	O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL85249	206024	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	1	3	4.0	O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	16006492	97441	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL270177	97441	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	10597140	63015	0	None	25	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL1788231	63015	0	None	25	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	5074	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	97	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	CHEMBL267777	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	DB12693	3307	80	None	-36	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	10767321	98241	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1021/jm970519e
	CHEMBL274595	98241	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1021/jm970519e
	10767321	98241	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL274595	98241	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1016/s0960-894x(00)00166-9
	10715998	45198	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	CHEMBL152595	45198	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	44368754	46871	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	561	7	0	4	6.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1	10.1021/jm030841r
	CHEMBL154090	46871	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	561	7	0	4	6.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1	10.1021/jm030841r
	142601328	184979	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	162664339	182104	0	None	-14	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4782149	182104	0	None	-14	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	24865727	193089	0	None	-10	11	Human	7.8	pKi	=	7.8	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	CHEMBL522708	193089	0	None	-10	11	Human	7.8	pKi	=	7.8	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	5074	3307	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	97	3307	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	CHEMBL267777	3307	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	DB12693	3307	80	None	-69	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	76284721	104981	0	None	27	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	480	10	1	5	3.9	O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113597	104981	0	None	27	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	480	10	1	5	3.9	O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	72550645	114062	0	None	-2	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326993	114062	0	None	-2	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	16006492	97441	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL270177	97441	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	46205696	124565	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	CHEMBL3640597	124565	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	71459269	82931	0	None	-660	8	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	CHEMBL2181166	82931	0	None	-660	8	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	45273816	195758	0	None	79	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	428	8	3	3	3.5	Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL557740	195758	0	None	79	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	428	8	3	3	3.5	Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	1220	187	55	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	31	187	55	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	7	187	55	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	CHEMBL56	187	55	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	46205696	124565	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	CHEMBL3640597	124565	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	24873257	180232	0	None	-10	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4750414	180232	0	None	-10	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	11312173	182087	0	None	-151	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4782005	182087	0	None	-151	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	66801430	157690	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	7	2	3	4.9	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4081987	157690	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	7	2	3	4.9	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	66801625	158261	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	7	2	3	5.7	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	CHEMBL4088925	158261	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	7	2	3	5.7	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	156021073	178142	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	CHEMBL4649078	178142	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	90644077	112060	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	7	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289981	112060	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	7	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	168279281	190998	0	None	-26	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	342	7	3	8	1.1	Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5186821	190998	0	None	-26	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	342	7	3	8	1.1	Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	71456677	81132	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	7	1	3	4.8	Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158027	81132	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	7	1	3	4.8	Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1	10.1016/j.ejmech.2012.07.043
	155568794	176074	0	None	-53	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	336	7	3	4	3.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4591410	176074	0	None	-53	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	336	7	3	4	3.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	122181344	121860	0	None	-4	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590096	121860	0	None	-4	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	164608896	184396	0	None	-223	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4846146	184396	0	None	-223	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	162666977	183711	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4787400	183711	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803559	183711	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	122483246	138073	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763582	138073	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765846	138073	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	127049059	140788	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818935	140788	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	52952202	62556	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	5	0	5	4.6	N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782800	62556	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	5	0	5	4.6	N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	155558408	174731	0	None	-16	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4560883	174731	0	None	-16	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	71462776	82934	0	None	-125	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181169	82934	0	None	-125	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	90654690	110049	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	418	9	1	5	2.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235727	110049	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	418	9	1	5	2.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	53361626	66397	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851948	66397	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216277	66397	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
	122483246	138073	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763582	138073	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765846	138073	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	162662435	183692	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4780228	183692	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803308	183692	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	11260739	85109	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	CHEMBL224929	85109	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	127036186	137389	0	None	-4	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3753318	137389	0	None	-4	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	44324535	13080	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL1190414	13080	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL540821	13080	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	155547197	173571	0	None	-758	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4533305	173571	0	None	-758	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	6918515	2594	38	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
	71	2594	38	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
	CHEMBL7318	2594	38	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
	55479093	81392	1	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	366	7	1	5	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159464	81392	1	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	366	7	1	5	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	46206018	124572	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	CHEMBL3640604	124572	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	46206018	124572	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	CHEMBL3640604	124572	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	11739679	169828	0	None	-776	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD	ChEMBL	353	3	2	5	2.8	Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1	10.1016/j.bmcl.2004.10.064
	CHEMBL444015	169828	0	None	-776	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD	ChEMBL	353	3	2	5	2.8	Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1	10.1016/j.bmcl.2004.10.064
	168298474	192695	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	384	8	0	5	3.9	CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	CHEMBL5219968	192695	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	384	8	0	5	3.9	CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	57399090	68392	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917342	68392	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	168284197	190832	0	None	-12	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	515	12	4	9	3.6	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5184538	190832	0	None	-12	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	515	12	4	9	3.6	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	888197	76706	4	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	241	5	0	2	3.3	CN(C)CCOc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	CHEMBL20666	76706	4	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	241	5	0	2	3.3	CN(C)CCOc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	10430623	18643	24	None	-1412	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	CHEMBL1277105	18643	24	None	-1412	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	162669046	183719	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4789585	183719	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803681	183719	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	86288950	112616	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL3233666	112616	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL3302931	112616	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	91937907	167616	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4218586	167616	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4301638	167616	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	122483290	138074	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765511	138074	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765847	138074	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	44461064	205566	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	287	4	0	4	2.3	COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81449	205566	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	287	4	0	4	2.3	COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	168268929	190006	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	456	9	5	7	4.4	Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5171734	190006	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	456	9	5	7	4.4	Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	12005903	51194	13	None	-117	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	482	5	0	7	4.0	CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1	10.1016/j.bmcl.2015.03.049
	CHEMBL1580288	51194	13	None	-117	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	482	5	0	7	4.0	CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1	10.1016/j.bmcl.2015.03.049
	44460739	205526	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81069	205526	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1	10.1016/s0960-894x(02)00438-9
	42626289	148055	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1021/jm8014553
	CHEMBL393492	148055	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1021/jm8014553
	11292933	56364	45	None	-794	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631540	56364	45	None	-794	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL5085390	214941	0	None	-12	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	155528865	171365	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4462108	171365	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	162645252	183601	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4743284	183601	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802393	183601	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	1150	3849	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	125	3849	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	CHEMBL6640	3849	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	DB08653	3849	121	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	122483290	138074	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765511	138074	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765847	138074	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	145967457	164327	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212698	164327	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	12843124	10232	27	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1ccc2c(c1)CC[C@@H](N)C2	10.1021/jm030826m
	CHEMBL1161325	10232	27	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1ccc2c(c1)CC[C@@H](N)C2	10.1021/jm030826m
	9891002	107381	0	None	-1584	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	CHEMBL318018	107381	0	None	-1584	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	10785644	97075	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1021/jm970519e
	CHEMBL267543	97075	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1021/jm970519e
	10785644	97075	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1016/s0960-894x(00)00166-9
	CHEMBL267543	97075	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1016/s0960-894x(00)00166-9
	44368383	119691	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL347511	119691	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	127050632	140718	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818124	140718	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	127049059	140788	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818935	140788	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	162663829	183696	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4779965	183696	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803379	183696	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	155528865	171365	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4462108	171365	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	164623862	185981	0	None	-79	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	CHEMBL4870361	185981	0	None	-79	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	127050632	140718	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818124	140718	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	44393022	64808	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182006	64808	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	168273329	190544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5180129	190544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	10106205	207114	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
	CHEMBL92221	207114	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
	44461066	104126	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	4	0	3	3.6	Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL309523	104126	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	4	0	3	3.6	Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	127026751	137655	0	None	23	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758622	137655	0	None	23	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	90178632	145403	0	None	9	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	468	10	1	5	4.1	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3914155	145403	0	None	9	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	468	10	1	5	4.1	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	134151980	153166	0	None	8	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	570	14	1	6	5.1	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3977072	153166	0	None	8	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	570	14	1	6	5.1	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	71456783	81408	0	None	1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159480	81408	0	None	1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	71449644	81412	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	CHEMBL2159484	81412	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	118731357	118167	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	516	9	0	4	5.0	O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409040	118167	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	516	9	0	4	5.0	O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	156016485	177749	0	None	-15	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	0	7	4.7	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3	10.1016/j.bmc.2020.115459
	CHEMBL4642981	177749	0	None	-15	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	0	7	4.7	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3	10.1016/j.bmc.2020.115459
	57384073	77176	0	None	-19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL2079256	77176	0	None	-19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	139488539	171400	0	None	19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	307	2	1	2	4.0	CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4462820	171400	0	None	19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	307	2	1	2	4.0	CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	156009593	177145	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	303	2	0	1	4.6	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4634558	177145	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	303	2	0	1	4.6	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1	10.1016/j.bmc.2019.115262
	142601328	184979	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	155557720	174623	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	494	10	1	7	3.2	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4558286	174623	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	494	10	1	7	3.2	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	54758297	65977	0	None	15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	349	6	1	3	3.7	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	CHEMBL1836856	65977	0	None	15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	349	6	1	3	3.7	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	135367857	164580	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	132604118	181969	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	420	8	1	7	2.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4780452	181969	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	420	8	1	7	2.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	10106205	207114	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030826m
	CHEMBL92221	207114	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030826m
	135367857	164580	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	10106205	207114	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1016/s0960-894x(02)00925-3
	CHEMBL92221	207114	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1016/s0960-894x(02)00925-3
	11025015	50169	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	CHEMBL157081	50169	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	25107518	187260	0	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL492871	187260	0	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	44324628	112348	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1cccs1	10.1016/s0960-894x(02)00925-3
	CHEMBL329548	112348	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1cccs1	10.1016/s0960-894x(02)00925-3
	90656695	110969	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262429	110969	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	168282260	190979	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	232	3	0	4	2.6	COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL5186652	190979	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	232	3	0	4	2.6	COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1	10.1021/acs.jmedchem.2c00633
	11595790	65971	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	368	6	1	4	3.2	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	CHEMBL1836790	65971	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	368	6	1	4	3.2	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	11646498	102477	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431051	102477	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040382	102477	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	9803482	204248	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	443	7	1	4	5.0	COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71224	204248	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	443	7	1	4	5.0	COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	127051845	140704	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140704	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	50878551	90716	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90716	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	156012890	177419	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4638770	177419	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	162645252	183601	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4743284	183601	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802393	183601	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	44424661	144522	0	None	-8	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	484	10	0	10	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL390734	144522	0	None	-8	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	484	10	0	10	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	118706287	120505	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310114	120505	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545466	120505	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	42625359	186823	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL489448	186823	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1	10.1021/jm8014553
	136216703	78876	0	None	-79	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	482	2	4	7	4.0	N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2	10.1016/s0960-894x(99)00075-x
	CHEMBL2112936	78876	0	None	-79	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	482	2	4	7	4.0	N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2	10.1016/s0960-894x(99)00075-x
	9796627	96624	0	None	-54	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
	CHEMBL263700	96624	0	None	-54	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
	15560577	185317	9	None	-31	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4859858	185317	9	None	-31	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	23906630	117903	5	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	1	2	2.9	O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403333	117903	5	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	1	2	2.9	O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	155566439	175774	0	None	-69	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2019.06.022
	CHEMBL4584325	175774	0	None	-69	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2019.06.022
	45273807	195781	0	None	28	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	400	6	3	3	2.7	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL558025	195781	0	None	28	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	400	6	3	3	2.7	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	71451441	81344	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	6	1	5	3.6	O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2	10.1016/j.ejmech.2012.07.043
	CHEMBL2159320	81344	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	6	1	5	3.6	O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2	10.1016/j.ejmech.2012.07.043
	155552826	174068	0	None	37	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	269	3	1	4	2.8	CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12	10.1039/C8MD00313K
	CHEMBL4544802	174068	0	None	37	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	269	3	1	4	2.8	CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12	10.1039/C8MD00313K
	53248361	62052	0	None	-104	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	568	7	0	5	3.2	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1	10.1021/jm1009956
	CHEMBL1774991	62052	0	None	-104	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	568	7	0	5	3.2	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1	10.1021/jm1009956
	90656686	110956	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	7	1	4	3.3	CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262416	110956	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	7	1	4	3.3	CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	90656679	110955	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	6	0	3	4.1	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262415	110955	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	6	0	3	4.1	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1	10.1016/j.ejmech.2014.04.034
	90656674	110945	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	5	1	4	2.7	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262399	110945	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	5	1	4	2.7	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	46233351	199152	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	270	5	0	3	3.3	Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	CHEMBL589524	199152	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	270	5	0	3	3.3	Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	127027390	137814	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	0	4	3.5	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759927	137814	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	0	4	3.5	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	168293886	192156	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	488	8	0	4	4.5	O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3	10.1016/j.ejmech.2022.114319
	CHEMBL5204088	192156	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	488	8	0	4	4.5	O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3	10.1016/j.ejmech.2022.114319
	155531065	171589	0	None	-229	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	332	6	3	3	4.5	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4465414	171589	0	None	-229	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	332	6	3	3	4.5	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	1355	1998	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	142	1998	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	CHEMBL478	1998	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	DB12110	1998	88	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	44461052	205853	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	391	4	0	3	4.5	CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL83802	205853	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	391	4	0	3	4.5	CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	90654689	110048	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	404	8	1	5	2.2	CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235726	110048	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	404	8	1	5	2.2	CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	127028634	137829	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	7	1	4	3.0	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3760121	137829	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	7	1	4	3.0	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	44424671	143439	0	None	-2	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	369	4	1	7	0.2	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL389842	143439	0	None	-2	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	369	4	1	7	0.2	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	137650961	157309	0	None	3	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4077538	157309	0	None	3	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	145982506	165371	0	None	-11	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238029	165371	0	None	-11	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	145987559	167124	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	441	7	2	5	2.5	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4290738	167124	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	441	7	2	5	2.5	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	44341131	9443	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	393	5	1	6	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL111956	9443	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	393	5	1	6	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	168291978	191989	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	482	6	3	7	4.2	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5201719	191989	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	482	6	3	7	4.2	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	118728527	117697	0	None	-7	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	424	8	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401490	117697	0	None	-7	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	424	8	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	71678345	89654	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376455	89654	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	24901425	62564	0	None	-10	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	6	2	5	4.5	N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782811	62564	0	None	-10	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	6	2	5	4.5	N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	44460639	163317	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	285	4	0	3	2.8	CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL419101	163317	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	285	4	0	3	2.8	CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	155569022	176412	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4592962	176412	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596261	176412	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	71678345	89654	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376455	89654	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	168268997	189947	0	None	-23	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	410	7	3	8	2.4	Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5170808	189947	0	None	-23	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	410	7	3	8	2.4	Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	168277941	190659	0	None	-7	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	374	9	2	4	1.8	NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5181868	190659	0	None	-7	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	374	9	2	4	1.8	NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	155519516	176334	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4447659	176334	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595677	176334	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	53322759	56982	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	4.9	FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644272	56982	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	4.9	FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	145971390	164610	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4216244	164610	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	71451345	81142	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	6	1	3	4.4	CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158037	81142	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	6	1	3	4.4	CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	137642224	158067	0	None	-758	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	323	3	2	6	1.3	CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2022.114645
	CHEMBL4086515	158067	0	None	-758	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	323	3	2	6	1.3	CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2022.114645
	127027389	137768	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	0	4	4.0	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759570	137768	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	0	4	4.0	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	118728506	117677	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	414	8	2	4	3.4	NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401469	117677	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	414	8	2	4	3.4	NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	42618261	181527	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	472	8	0	7	4.0	COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476616	181527	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	472	8	0	7	4.0	COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	56850665	71476	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926749	71476	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962697	71476	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	162659577	181334	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4763106	181334	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	44324402	13407	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL1192985	13407	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL544315	13407	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL5275931	193853	0	None	-26	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	629	10	0	8	5.4	O=C1CC2CCc3ccsc3C2=NN1CCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
	71727066	91236	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401936	91236	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL3215930	91236	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	46206023	124577	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640609	124577	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	46206023	124577	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640609	124577	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	44461045	104703	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	403	4	0	3	4.7	Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL310594	104703	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	403	4	0	3	4.7	Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	76325347	106368	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121420	106368	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139440	106368	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	127028797	138308	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771309	138308	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	127026444	137822	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3760017	137822	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	145985224	165464	0	None	-4	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240162	165464	0	None	-4	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71458623	81331	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	6	3.9	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159308	81331	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	6	3.9	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1016/j.ejmech.2012.07.043
	156021535	178160	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649289	178160	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	56945043	156381	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4066532	156381	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	156013801	177258	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	1	0	2	3.5	CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4636329	177258	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	1	0	2	3.5	CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	127051845	140704	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140704	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	50878551	90716	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90716	61	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	73346042	91805	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1021/acs.jmedchem.2c00633
	CHEMBL2413153	91805	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1021/acs.jmedchem.2c00633
	73346042	91805	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	CHEMBL2413153	91805	5	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	15542627	204186	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	432	7	2	4	3.3	NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL70869	204186	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	432	7	2	4	3.3	NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	136152966	95564	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
	CHEMBL257744	95564	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
	11277147	106314	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092759	106314	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139188	106314	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	162664480	182184	0	None	26	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	441	9	0	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4783043	182184	0	None	26	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	441	9	0	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	44374298	54368	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	278	5	0	4	3.8	Cc1sc(SCCN(C)C)nc1-c1ccccc1	10.1016/j.bmcl.2003.11.050
	CHEMBL160903	54368	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	278	5	0	4	3.8	Cc1sc(SCCN(C)C)nc1-c1ccccc1	10.1016/j.bmcl.2003.11.050
	145964086	164150	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4210561	164150	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	44439394	145097	0	None	398	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	CHEMBL391191	145097	0	None	398	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	3377940	91750	21	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	278	2	2	2	3.4	COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL241098	91750	21	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	278	2	2	2	3.4	COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	136152972	95195	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL256047	95195	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	168277502	190691	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	468	8	0	5	6.2	S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	CHEMBL5182383	190691	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	468	8	0	5	6.2	S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	155533534	171860	0	None	-131	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4469537	171860	0	None	-131	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	90654848	112670	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233673	112670	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304318	112670	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	145974184	164599	0	None	50	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	CHEMBL4216040	164599	0	None	50	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	145988913	167145	0	None	23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	475	7	2	5	3.2	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4291141	167145	0	None	23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	475	7	2	5	3.2	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O	10.1039/C8MD00168E
	18377388	205955	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	394	6	0	3	4.9	CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	CHEMBL84660	205955	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	394	6	0	3	4.9	CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	71602587	89651	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376448	89651	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	137652044	157143	0	None	2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4075422	157143	0	None	2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	71727064	102381	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
	CHEMBL3039719	102381	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
	CHEMBL3216145	102381	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
	9872676	78166	0	None	-4365	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
	CHEMBL210514	78166	0	None	-4365	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
	71602587	89651	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376448	89651	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	12374770	175479	2	None	20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	268	7	2	2	2.5	O=C(CCNCc1ccccc1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	CHEMBL4577789	175479	2	None	20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	268	7	2	2	2.5	O=C(CCNCc1ccccc1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	45272864	196527	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	338	5	3	3	1.5	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL563760	196527	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	338	5	3	3	1.5	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1	10.1016/j.bmcl.2009.06.038
	127029651	138196	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C	10.1016/j.ejmech.2016.02.024
	CHEMBL3770110	138196	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C	10.1016/j.ejmech.2016.02.024
	CHEMBL5080719	214679	0	None	-64	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3o2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	155561915	176446	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4585051	176446	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596544	176446	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
	71460468	81396	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	7	1	4	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159468	81396	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	7	1	4	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1	10.1016/j.ejmech.2012.07.043
	118729733	117908	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	394	4	1	3	5.4	O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403338	117908	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	394	4	1	3	5.4	O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1	10.1016/j.bmcl.2015.03.049
	90654702	110061	0	None	-44	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	440	8	1	4	3.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235739	110061	0	None	-44	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	440	8	1	4	3.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	164615095	184923	0	None	-13	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	414	7	0	6	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4853700	184923	0	None	-13	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	414	7	0	6	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2021.128028
	11675876	187490	0	None	-54	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL494316	187490	0	None	-54	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	13069598	120589	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360998	120589	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546116	120589	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	90656680	110954	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	343	6	0	3	4.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262414	110954	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	343	6	0	3	4.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2014.04.034
	90469114	184398	0	None	-588	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	426	3	1	6	3.5	O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	CHEMBL4846153	184398	0	None	-588	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	426	3	1	6	3.5	O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	42618258	189711	0	None	-47	2	Human	4.8	pKi	=	4.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	0	5	4.2	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL515789	189711	0	None	-47	2	Human	4.8	pKi	=	4.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	0	5	4.2	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	11697434	130443	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2005.05.059
	CHEMBL368044	130443	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2005.05.059
	10499156	114064	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.2c00633
	CHEMBL332701	114064	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.2c00633
	10084076	97888	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
	CHEMBL27251	97888	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
	68788	207584	14	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL95067	207584	14	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	134138168	147666	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	76325351	106252	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121437	106252	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139023	106252	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	76336179	106371	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3121421	106371	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3139443	106371	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	137653850	159021	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4096866	159021	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	90654686	110080	0	None	21	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	461	7	1	6	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235758	110080	0	None	21	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	461	7	1	6	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	168275477	190427	0	None	263	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	388	9	5	7	3.1	Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5178499	190427	0	None	263	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	388	9	5	7	3.1	Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	127037922	136962	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	508	10	0	4	5.4	O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3745853	136962	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	508	10	0	4	5.4	O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	127041258	137055	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747114	137055	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	118731348	118159	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	10	1	4	3.9	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409032	118159	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	10	1	4	3.9	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	139488740	170124	0	None	97	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	258	2	2	3	1.8	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4444268	170124	0	None	97	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	258	2	2	3	1.8	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	156020374	178038	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4647335	178038	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1	10.1016/j.bmc.2019.115262
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	11358099	180382	0	None	-17	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4752099	180382	0	None	-17	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	56944951	156613	0	None	-6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	CHEMBL4069237	156613	0	None	-6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	71061607	93092	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442999	93092	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061607	93092	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442999	93092	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	10084076	97888	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm9911433
	CHEMBL27251	97888	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm9911433
	10084076	97888	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm0108505
	CHEMBL27251	97888	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm0108505
	134137104	142667	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142667	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	134138168	147666	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3931889	147666	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1016/j.ejmech.2016.07.029
	11277147	106314	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3092759	106314	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3139188	106314	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	11697434	130443	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL368044	130443	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2007.03.054
	66801120	112087	0	None	-5	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	7	1	5	5.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3290007	112087	0	None	-5	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	7	1	5	5.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	135398737	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	38	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	722	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	CHEMBL42	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	DB00363	955	93	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	1342	36	49	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
	3	36	49	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
	CHEMBL277120	36	49	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
	162661196	181437	0	None	-24	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4764468	181437	0	None	-24	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	18663036	81791	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL2164344	81791	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	134133483	143184	0	None	5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	614	16	1	7	5.5	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3896355	143184	0	None	5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	614	16	1	7	5.5	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	44266317	207920	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	349	4	0	3	4.4	O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21	10.1016/s0960-894x(03)00077-5
	CHEMBL9696	207920	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	349	4	0	3	4.4	O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21	10.1016/s0960-894x(03)00077-5
	117209858	184530	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184530	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL5080955	214689	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(Cl)c1	10.1021/acs.jmedchem.1c00497
	122196381	124269	0	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	CHEMBL3634821	124269	0	None	-1	5	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	156017272	177628	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	287	2	0	1	4.1	CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4641478	177628	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	287	2	0	1	4.1	CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1	10.1016/j.bmc.2019.115262
	156019520	177975	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646359	177975	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	66800959	157414	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	413	6	2	3	3.7	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4078873	157414	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	413	6	2	3	3.7	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	118706296	120499	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310119	120499	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545441	120499	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	71151588	118232	0	None	-1778	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
	CHEMBL3409256	118232	0	None	-1778	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
	66801333	112061	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	7	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289982	112061	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	7	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	46205702	124570	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640602	124570	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46205702	124570	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640602	124570	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL5287809	194373	0	None	-218	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	615	10	0	8	5.0	O=C1CC2Cc3ccsc3C2=NN1CCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
	2948971	73182	9	None	-25	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	397	2	3	1	5.6	O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL2011865	73182	9	None	-25	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	397	2	3	1	5.6	O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	134131265	142161	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	8	0	5	5.0	Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	CHEMBL3883995	142161	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	8	0	5	5.0	Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	44324602	207406	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	3	4.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL94056	207406	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	3	4.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1	10.1016/s0960-894x(02)00925-3
	44460744	205700	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	6	0	4	3.9	CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL82550	205700	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	6	0	4	3.9	CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	44424669	85695	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	412	6	1	8	0.3	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL228939	85695	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	412	6	1	8	0.3	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	168291393	191970	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	338	8	2	3	2.7	NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5201464	191970	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	338	8	2	3	2.7	NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	155515408	176308	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4442062	176308	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595453	176308	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
	23369450	181548	2	None	-72	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	352	5	1	5	2.2	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476822	181548	2	None	-72	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	352	5	1	5	2.2	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	53377140	66375	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851835	66375	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216729	66375	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
	155515890	169978	0	None	-5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	414	8	0	4	4.6	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4442385	169978	0	None	-5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	414	8	0	4	4.6	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	11667626	102557	0	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431042	102557	0	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040827	102557	0	None	-11	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	135398745	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	47	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	CHEMBL715	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	DB00334	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	118728512	117681	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	423	8	1	4	5.3	Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401475	117681	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	423	8	1	4	5.3	Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	23151734	103931	0	None	-467	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092758	103931	0	None	-467	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	71602586	89650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	CHEMBL2376447	89650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	168281784	190923	0	None	-30	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	429	8	0	6	4.0	O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5185787	190923	0	None	-30	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	429	8	0	6	4.0	O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	11432215	84270	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	CHEMBL221453	84270	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	164619236	185685	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4865591	185685	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	72549767	114045	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	429	8	1	4	4.2	COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326976	114045	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	429	8	1	4	4.2	COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	71602586	89650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	CHEMBL2376447	89650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	90654696	110055	0	None	-35	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	374	7	2	5	1.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235733	110055	0	None	-35	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	374	7	2	5	1.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	42618257	181572	0	None	-11	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL477066	181572	0	None	-11	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	57400830	68408	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917358	68408	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	164619236	185685	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4865591	185685	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	162676036	183761	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4798934	183761	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804093	183761	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	228	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	33	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	6005	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	CHEMBL53	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	DB00714	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	156015087	177516	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	406	7	1	4	4.8	C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640150	177516	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	406	7	1	4	4.8	C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	228	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	33	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	6005	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	CHEMBL53	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	DB00714	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	228	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	33	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	6005	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	CHEMBL53	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	DB00714	444	28	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	44424668	144348	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	432	5	1	8	0.6	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL390581	144348	0	None	-1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	432	5	1	8	0.6	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	76336182	105481	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121430	105481	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	127051016	140851	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819642	140851	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819734	140851	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	46205046	124555	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	CHEMBL3640587	124555	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	46205046	124555	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	CHEMBL3640587	124555	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	46203755	124520	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	CHEMBL3640554	124520	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	46205371	124559	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	CHEMBL3640591	124559	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	11617668	64666	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL181874	64666	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	4806	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	7351	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	9966051	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	CHEMBL2104993	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	DB09068	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	4806	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	7351	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL2104993	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	DB09068	3977	88	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	11384575	66144	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	418	9	0	5	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1	10.1021/jm049743b
	CHEMBL184310	66144	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	418	9	0	5	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1	10.1021/jm049743b
	11373831	124623	0	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	CHEMBL364124	124623	0	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	46203755	124520	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	CHEMBL3640554	124520	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	46205371	124559	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	CHEMBL3640591	124559	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	11373831	124623	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1016/j.bmc.2011.09.044
	CHEMBL364124	124623	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1016/j.bmc.2011.09.044
	127026750	137652	0	None	14	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758591	137652	0	None	14	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	118626089	165449	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239823	165449	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626035	165494	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240954	165494	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983760	165516	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241497	165516	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983390	165895	0	None	-6	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4250274	165895	0	None	-6	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	134156305	154225	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3986254	154225	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	145993714	167328	0	None	21	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4294549	167328	0	None	21	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	127037681	136589	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	406	8	1	6	2.4	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1	10.1039/C5MD00166H
	CHEMBL3739745	136589	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	406	8	1	6	2.4	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1	10.1039/C5MD00166H
	127041106	136757	0	None	16	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	440	8	1	6	2.9	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1039/C5MD00166H
	CHEMBL3741281	136757	0	None	16	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	440	8	1	6	2.9	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1039/C5MD00166H
	117209858	184530	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184530	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	66800934	112027	0	None	-8	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	9	1	7	4.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289949	112027	0	None	-8	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	9	1	7	4.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	118626089	165449	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239823	165449	3	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	11101733	102805	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	413	5	1	3	4.9	Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL305526	102805	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	413	5	1	3	4.9	Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	10896196	204238	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	484	7	1	4	4.5	CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71170	204238	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	484	7	1	4	4.5	CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	155555378	174410	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4553199	174410	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	10948529	54129	0	None	54	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	365	6	1	6	3.3	O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL160706	54129	0	None	54	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	365	6	1	6	3.3	O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	46205375	124563	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640595	124563	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	46205375	124563	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640595	124563	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	162675490	183105	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	503	8	2	7	3.6	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4795056	183105	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	503	8	2	7	3.6	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	2470	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	3300	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	5265	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	99	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	CHEMBL267930	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	10552788	18639	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm970519e
	CHEMBL12771	18639	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm970519e
	10552788	18639	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12771	18639	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1016/s0960-894x(00)00166-9
	44368304	44876	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	479	6	0	3	5.1	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm030841r
	CHEMBL152292	44876	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	479	6	0	3	5.1	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm030841r
	134138168	147666	0	None	-1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	-1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5094493	215476	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	153287541	172171	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4473697	172171	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	135398737	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	38	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	722	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	CHEMBL42	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	DB00363	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	24865725	188060	0	None	-39	12	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	CHEMBL497963	188060	0	None	-39	12	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	2470	3626	50	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	3300	3626	50	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	5265	3626	50	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	99	3626	50	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	CHEMBL267930	3626	50	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	162668859	183718	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4788452	183718	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803670	183718	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	156020807	178024	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4647184	178024	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	127051016	140851	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819642	140851	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819734	140851	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	6918542	204901	24	None	-537	10	Human	5.7	pKi	=	5.7	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL76237	204901	24	None	-537	10	Human	5.7	pKi	=	5.7	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	122483296	138080	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764934	138080	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765870	138080	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	164623281	185788	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	447	7	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4867109	185788	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	447	7	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	90656704	112658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262435	112658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304198	112658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	122483296	138080	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764934	138080	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765870	138080	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	71450247	82947	0	None	-380	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181188	82947	0	None	-380	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	127026434	137715	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	9	1	4	4.9	CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759170	137715	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	9	1	4	4.9	CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	76314437	105479	0	None	25	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	443	5	0	3	6.6	c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121418	105479	0	None	25	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	443	5	0	3	6.6	c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1	10.1016/j.ejmech.2014.01.055
	155534362	171880	0	None	-91	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	522	8	1	6	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	CHEMBL4469813	171880	0	None	-91	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	522	8	1	6	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	168287508	191507	0	None	-48	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	438	9	3	8	3.1	Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5194270	191507	0	None	-48	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	438	9	3	8	3.1	Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	156020306	178105	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	602	11	0	6	6.9	O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1	10.1016/j.bmc.2020.115459
	CHEMBL4648390	178105	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	602	11	0	6	6.9	O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1	10.1016/j.bmc.2020.115459
	42625267	186783	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1	10.1021/jm8014553
	CHEMBL489255	186783	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1	10.1021/jm8014553
	73213196	104433	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	104433	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	164622318	185812	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4867534	185812	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	71455625	82935	0	None	-48977	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181170	82935	0	None	-48977	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	73213196	104433	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	CHEMBL3104093	104433	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	44517732	195208	0	None	50	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	8	3	5	2.9	COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL550881	195208	0	None	50	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	8	3	5	2.9	COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	71727065	102382	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401931	102382	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL3039720	102382	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
	73213196	104433	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	104433	4	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	51002362	82593	0	None	-3	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	CHEMBL2179222	82593	0	None	-3	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	168273001	190188	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	403	9	4	7	3.3	COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5174637	190188	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	403	9	4	7	3.3	COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	72197845	89815	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	CHEMBL2377590	89815	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	72197845	89815	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377590	89815	0	None	-25	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	127026143	137772	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	3	5.3	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759593	137772	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	3	5.3	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	155540198	172879	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	406	7	0	4	3.3	O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4516076	172879	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	406	7	0	4	3.3	O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	4790508	8143	4	None	-24	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	333	7	2	5	2.0	OC(CNCC1COc2ccccc2O1)COc1ccccc1F	10.1016/j.bmcl.2010.03.012
	CHEMBL1091933	8143	4	None	-24	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	333	7	2	5	2.0	OC(CNCC1COc2ccccc2O1)COc1ccccc1F	10.1016/j.bmcl.2010.03.012
	44424658	85734	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229180	85734	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	23290944	81797	0	None	-131	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164350	81797	0	None	-131	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	45269494	196643	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	7	3	3	3.5	N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1	10.1016/j.bmcl.2009.06.038
	CHEMBL564509	196643	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	7	3	3	3.5	N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1	10.1016/j.bmcl.2009.06.038
	127026146	137749	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	449	7	2	3	5.7	O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759437	137749	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	449	7	2	3	5.7	O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2015.11.040
	156018383	177899	0	None	-16	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4645308	177899	0	None	-16	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2020.115459
	53381002	65435	0	None	-22	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	CHEMBL1829959	65435	0	None	-22	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	164620867	185618	0	None	-177	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4864448	185618	0	None	-177	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	156018897	177788	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	356	4	1	3	3.6	CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4643640	177788	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	356	4	1	3	3.6	CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	11397459	19325	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12908	19325	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	11259115	19372	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12933	19372	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	11453756	19956	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL13032	19956	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	11382534	98077	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL273452	98077	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	49850567	56439	0	None	-999	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632217	56439	0	None	-999	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	11397459	19325	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	CHEMBL12908	19325	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	11259115	19372	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL12933	19372	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	11453756	19956	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	CHEMBL13032	19956	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	11382534	98077	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL273452	98077	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	71602690	89658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376459	89658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	153287567	172360	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	CHEMBL4476396	172360	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	155557042	174533	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	CHEMBL4556297	174533	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	153287557	176055	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591108	176055	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	10296414	3505	15	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	76	3505	15	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	CHEMBL183460	3505	15	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	73213195	104432	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	104432	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	164610456	184476	0	None	-61	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	328	5	1	7	1.7	CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4847379	184476	0	None	-61	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	328	5	1	7	1.7	CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	9891618	107097	0	None	-1995	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
	CHEMBL316081	107097	0	None	-1995	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
	44393088	64983	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.ejmech.2019.111705
	CHEMBL182322	64983	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.ejmech.2019.111705
	44393113	63601	0	None	5	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	358	7	3	7	3.5	CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL180086	63601	0	None	5	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	358	7	3	7	3.5	CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	10475231	65357	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182937	65357	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	44393161	66666	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	334	8	2	5	4.1	C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185511	66666	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	334	8	2	5	4.1	C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393045	161635	0	None	9	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	370	7	3	6	3.6	C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL413049	161635	0	None	9	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	370	7	3	6	3.6	C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	107	141	121	None	-3	31	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
	1833	141	121	None	-3	31	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
	CHEMBL8165	141	121	None	-3	31	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
	145970078	164787	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	3	5.3	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.7b01898
	CHEMBL4218549	164787	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	3	5.3	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.7b01898
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
	10028436	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
	3237	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
	CHEMBL95104	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
	1621	2413	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	17	2413	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	5761	2413	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	CHEMBL263881	2413	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	DB04829	2413	17	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	127025242	137777	0	None	70	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759617	137777	0	None	70	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	71455002	81417	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159489	81417	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	155534839	171974	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4471208	171974	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1	10.1016/j.bmcl.2019.126703
	56944954	157542	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	445	7	3	4	4.0	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4080399	157542	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	445	7	3	4	4.0	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	56944956	158895	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4095555	158895	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	10834268	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/j.bmc.2019.06.028
	CHEMBL428494	166802	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/j.bmc.2019.06.028
	10028436	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
	3237	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
	CHEMBL95104	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
	66800909	112043	0	None	4	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	8	3.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289965	112043	0	None	4	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	8	3.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	10274894	165166	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	438	6	1	2	6.0	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL422869	165166	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	438	6	1	2	6.0	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	44266182	207301	0	None	23	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	407	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9347	207301	0	None	23	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	407	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	24854368	159794	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	377	7	1	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410628	159794	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	377	7	1	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
	5	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	5202	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	CHEMBL39	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	DB08839	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	11633354	95951	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	CHEMBL259550	95951	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	11633354	95951	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL259550	95951	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	5	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	5202	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	CHEMBL39	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	DB08839	139	72	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	439280	119993	107	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
	6971044	119993	107	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
	CHEMBL350221	119993	107	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
	10500557	16648	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2009.12.027
	CHEMBL12427	16648	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2009.12.027
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
	44276598	95654	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2010.03.012
	CHEMBL25815	95654	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2010.03.012
	9845006	18207	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm070279v
	CHEMBL12702	18207	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm070279v
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
	141745657	172353	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	394	5	1	4	4.7	Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	CHEMBL4476294	172353	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	394	5	1	4	4.7	Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	4106	2485	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	5358812	2485	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	89	2485	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	CHEMBL93240	2485	22	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	44437327	90838	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239231	90838	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	9888494	98143	0	None	1	13	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273921	98143	0	None	1	13	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	9888494	98143	0	None	-1	13	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1021/jm0498102
	CHEMBL273921	98143	0	None	-1	13	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1021/jm0498102
	118706734	120500	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310714	120500	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545444	120500	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	145993474	167293	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4294077	167293	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	10862697	204362	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1	10.1021/jm0104264
	CHEMBL71847	204362	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1	10.1021/jm0104264
	44327688	112637	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL330353	112637	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	44327688	112637	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1021/jm030030n
	CHEMBL330353	112637	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1021/jm030030n
	16006605	97964	3	None	2	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL272781	97964	3	None	2	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	135966709	155131	4	None	10	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
	CHEMBL402179	155131	4	None	10	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
	24825775	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	3929	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	CHEMBL4205349	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	24825775	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	3929	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	CHEMBL4205349	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	4376990	192985	5	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192985	5	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192985	5	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	24825775	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
	3929	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
	CHEMBL4205349	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
	CHEMBL5074190	214291	0	None	29	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	24825775	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	3929	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	CHEMBL4205349	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	16093485	155039	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	CHEMBL401745	155039	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	44266315	98357	0	None	30	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	410	5	0	3	4.3	O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275343	98357	0	None	30	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	410	5	0	3	4.3	O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL5074190	214291	0	None	29	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	11153905	65576	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1016/j.bmc.2010.01.035
	CHEMBL183329	65576	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1016/j.bmc.2010.01.035
	24854369	96171	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL260762	96171	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	10064052	124243	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	CHEMBL363466	124243	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	10064052	124243	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	CHEMBL363466	124243	0	None	93	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	22001618	81784	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.ejmech.2019.111705
	CHEMBL2164336	81784	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.ejmech.2019.111705
	22001618	81784	10	None	-1	3	Rat	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.bmc.2013.06.020
	CHEMBL2164336	81784	10	None	-1	3	Rat	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.bmc.2013.06.020
	11545363	190474	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	379	7	1	4	3.7	COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1	10.1021/acs.jmedchem.2c00633
	CHEMBL5179267	190474	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	379	7	1	4	3.7	COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1	10.1021/acs.jmedchem.2c00633
	168269899	190053	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5172635	190053	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	22001618	81784	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164336	81784	10	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	66801018	112065	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	502	8	1	7	4.4	Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289986	112065	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	502	8	1	7	4.4	Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	145991864	166981	0	None	5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4288120	166981	0	None	5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	153287566	171156	0	None	74	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4459009	171156	0	None	74	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	23133427	81780	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164332	81780	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	118709756	113520	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113520	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	11772153	66843	0	None	3	3	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	CHEMBL186316	66843	0	None	3	3	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	44437335	151633	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396396	151633	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44266222	208347	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	0	3	4.4	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9952	208347	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	0	3	4.4	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL5077293	214468	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	162666034	182287	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4784228	182287	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL5077293	214468	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5094234	215550	0	None	2	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215550	0	None	2	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11697659	95826	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	CHEMBL259010	95826	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	11697659	95826	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL259010	95826	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL5091373	215544	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	118713593	114352	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	338	5	0	4	3.9	O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331262	114352	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	338	5	0	4	3.9	O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	90656683	110948	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262408	110948	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	118713684	114362	0	None	-6	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	425	9	0	6	4.5	COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331387	114362	0	None	-6	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	425	9	0	6	4.5	COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	11186985	123820	0	None	-11	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	CHEMBL362540	123820	0	None	-11	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	11267988	66799	0	None	-2	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	CHEMBL186112	66799	0	None	-2	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	10430685	54269	0	None	64	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL160817	54269	0	None	64	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	118713682	114360	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	5	4.4	O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331385	114360	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	5	4.4	O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	118728530	117700	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	454	9	0	7	4.5	CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401493	117700	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	454	9	0	7	4.5	CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	42388639	188030	0	None	-4	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL497749	188030	0	None	-4	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2009.06.038
	90656685	110947	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262407	110947	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	2470	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3626	50	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL5094493	215476	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	76336181	106372	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121425	106372	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139444	106372	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	76318013	106373	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121427	106373	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139445	106373	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	127026452	137648	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	1	4	5.0	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758569	137648	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	1	4	5.0	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2015.11.040
	127024949	137771	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	442	8	1	4	4.0	O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759581	137771	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	442	8	1	4	4.0	O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	71454997	81382	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	9	1	5	5.1	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159455	81382	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	9	1	5	5.1	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	145947405	167647	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4159967	167647	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301968	167647	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	138691316	174664	0	None	61	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	289	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4559312	174664	0	None	61	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	289	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	59752638	182373	0	None	-1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4785470	182373	0	None	-1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	11732538	204278	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1016/j.bmc.2019.06.028
	CHEMBL71390	204278	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1016/j.bmc.2019.06.028
	90656685	110947	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262407	110947	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	118713595	114354	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	4.1	O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331264	114354	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	4.1	O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	44439392	91753	0	None	4677	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	5	2	2	5.1	CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241100	91753	0	None	4677	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	5	2	2	5.1	CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	66801613	112023	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289945	112023	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	122178709	121349	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581254	121349	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	16573	177595	34	None	8	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL464099	177595	34	None	8	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	11341035	144317	0	None	1	2	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL390558	144317	0	None	1	2	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	42618265	182644	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	378	8	1	4	3.7	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL478905	182644	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	378	8	1	4	3.7	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	44266229	207695	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	364	5	0	3	3.6	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9564	207695	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	364	5	0	3	3.6	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	14566720	101868	11	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	242	2	1	3	2.3	COc1ccc2cccc(N3CCNCC3)c2c1	10.1021/jm030826m
	CHEMBL300824	101868	11	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	242	2	1	3	2.3	COc1ccc2cccc(N3CCNCC3)c2c1	10.1021/jm030826m
	11732538	204278	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	CHEMBL71390	204278	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	11725453	99052	0	None	1	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	CHEMBL28056	99052	0	None	1	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	90656669	110962	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262422	110962	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	11725453	99052	0	None	-1	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL28056	99052	0	None	-1	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	11397459	19325	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL12908	19325	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	11259115	19372	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL12933	19372	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	11453756	19956	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL13032	19956	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	127040443	136684	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	382	9	1	4	3.2	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1039/C5MD00166H
	CHEMBL3740624	136684	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	382	9	1	4	3.2	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1039/C5MD00166H
	44439408	91186	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	426	4	0	5	4.9	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL240024	91186	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	426	4	0	5	4.9	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2	10.1016/j.bmcl.2007.01.093
	44439396	91782	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	348	3	0	3	4.3	CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241281	91782	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	348	3	0	3	4.3	CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	66800926	112064	0	None	6	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	7	1	7	4.0	Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289985	112064	0	None	6	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	7	1	7	4.0	Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL5284727	194236	0	None	-8	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	615	9	0	8	5.0	O=C1CC2CCc3ccsc3C2=NN1CCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
	2872937	117902	6	None	-2	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	464	4	1	5	4.7	O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403332	117902	6	None	-2	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	464	4	1	5	4.7	O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1	10.1016/j.bmcl.2015.03.049
	127026145	137679	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	399	7	2	3	4.6	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758814	137679	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	399	7	2	3	4.6	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL5275394	193828	0	None	-10	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	601	9	0	8	4.6	O=C1CC2Cc3ccsc3C2=NN1CCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
	156010319	177018	0	None	-3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4632519	177018	0	None	-3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115459
	145978420	163977	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4208306	163977	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	155546190	176461	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4530770	176461	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596654	176461	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	42626291	192689	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL521973	192689	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	71462154	81334	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	396	9	1	4	4.1	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159311	81334	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	396	9	1	4	4.1	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1	10.1016/j.ejmech.2012.07.043
	145977555	163618	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	CHEMBL4204033	163618	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	CHEMBL5092755	215364	0	None	-120	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1ccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)cc1C	10.1021/acs.jmedchem.1c00497
	5249591	169253	1	None	-257	2	Rat	5.7	pKi	=	5.7	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	419	4	0	5	3.4	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL441313	169253	1	None	-257	2	Rat	5.7	pKi	=	5.7	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	419	4	0	5	3.4	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	135398745	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	47	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	CHEMBL715	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	DB00334	2893	112	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	155566191	175715	0	None	-67	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4583082	175715	0	None	-67	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	57390694	70437	0	None	-9	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946255	70437	0	None	-9	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	53323186	56983	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644273	56983	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1	10.1016/j.bmcl.2010.11.078
	155563452	175285	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4573441	175285	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	57396417	71518	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949975	71518	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1963009	71518	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	44209472	70143	2	None	-114	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	CHEMBL1940420	70143	2	None	-114	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	134144304	154469	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3952251	154469	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3990525	154469	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	155563452	175285	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4573441	175285	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	752521	198714	8	None	-102	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	198714	8	None	-102	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	145990093	166978	0	None	9	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	440	7	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4288077	166978	0	None	9	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	440	7	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	137649997	157265	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4076903	157265	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	145992305	166975	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	371	5	2	6	0.4	CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4288040	166975	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	371	5	2	6	0.4	CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	46205369	124557	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	CHEMBL3640589	124557	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	46206019	124573	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640605	124573	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	46205369	124557	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	CHEMBL3640589	124557	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	46206019	124573	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640605	124573	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	155537074	172246	0	None	-147	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12	10.1016/j.ejmech.2019.111857
	CHEMBL4474618	172246	0	None	-147	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12	10.1016/j.ejmech.2019.111857
	46203751	124517	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	CHEMBL3640551	124517	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	44388858	61467	0	None	-2	4	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL177064	61467	0	None	-2	4	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	44388858	61467	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL177064	61467	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.ejmech.2014.01.055
	76320704	103511	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	CHEMBL3085300	103511	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	2726	916	68	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	621	916	68	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	83	916	68	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	CHEMBL71	916	68	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	DB00477	916	68	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	68788	207584	14	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL95067	207584	14	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	46203751	124517	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	CHEMBL3640551	124517	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	145975720	163936	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	394	4	1	4	2.5	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4207835	163936	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	394	4	1	4	2.5	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	134151118	152177	0	None	3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	498	12	1	4	5.4	CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3968569	152177	0	None	3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	498	12	1	4	5.4	CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	71453278	81395	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	7	1	3	4.5	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F	10.1016/j.ejmech.2012.07.043
	CHEMBL2159467	81395	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	7	1	3	4.5	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F	10.1016/j.ejmech.2012.07.043
	135398737	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	38	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	722	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	CHEMBL42	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	DB00363	955	93	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	71574204	86238	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312640	86238	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	155557443	174620	0	None	9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	3	2.7	COc1ccc2[nH]cc(-c3cncn3C)c2c1F	10.1016/j.ejmech.2019.03.017
	CHEMBL4558202	174620	0	None	9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	3	2.7	COc1ccc2[nH]cc(-c3cncn3C)c2c1F	10.1016/j.ejmech.2019.03.017
	127037682	136568	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1	10.1039/C5MD00166H
	CHEMBL3739561	136568	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1	10.1039/C5MD00166H
	42618269	90958	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	397	6	0	4	3.1	O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239680	90958	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	397	6	0	4	3.1	O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	24854109	161262	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	397	6	1	3	4.5	CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL412143	161262	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	397	6	1	3	4.5	CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	136180317	117685	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401479	117685	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL5082182	214770	1	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(Cl)c1	10.1021/acs.jmedchem.1c00497
	44324403	206862	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	265	2	2	3	3.3	Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL90752	206862	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	265	2	2	3	3.3	Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	11811833	103042	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	418	7	1	3	5.0	COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL307352	103042	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	418	7	1	3	5.0	COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL5077755	214490	0	None	-12	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(Cl)c(Cl)c1	10.1021/acs.jmedchem.1c00497
	57401515	68369	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	498	8	0	5	4.0	COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL1916745	68369	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	498	8	0	5	4.0	COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	44582676	189755	0	None	-1	17	Human	6.7	pKi	=	6.7	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL516088	189755	0	None	-1	17	Human	6.7	pKi	=	6.7	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	11373934	84650	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL222507	84650	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL5283557	194194	0	None	-2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	484	6	0	5	4.8	O=C1CC2CCc3ccsc3C2=NN1Cc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmc.2023.117256
	60165537	75322	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	308	5	0	3	4.6	c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	CHEMBL2037523	75322	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	308	5	0	3	4.6	c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	73213195	104432	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	104432	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	22065997	99327	0	None	-64	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	CHEMBL282424	99327	0	None	-64	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	145964694	164013	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4208791	164013	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	145947301	167640	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4160262	167640	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301925	167640	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145976787	163602	0	None	20	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203823	163602	0	None	20	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	118728529	117699	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401492	117699	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	155564110	175345	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4574793	175345	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	122483297	138066	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763670	138066	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765839	138066	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	155564110	175345	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4574793	175345	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	22330705	117916	8	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	438	3	0	3	5.5	Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403345	117916	8	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	438	3	0	3	5.5	Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12	10.1016/j.bmcl.2015.03.049
	25107650	187261	0	None	-23	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	CHEMBL492872	187261	0	None	-23	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	122483297	138066	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763670	138066	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765839	138066	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	155569568	176170	0	None	-32	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	380	7	2	3	5.4	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4593671	176170	0	None	-32	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	380	7	2	3	5.4	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	145990459	166938	0	None	2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	490	7	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4287320	166938	0	None	2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	490	7	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	71602689	89657	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376458	89657	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	162669595	182720	0	None	-24	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4790020	182720	0	None	-24	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	71602689	89657	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376458	89657	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	71456780	81390	0	None	-7	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	4	3.5	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159462	81390	0	None	-7	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	4	3.5	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2012.07.043
	44374225	54716	0	None	54	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	244	4	0	4	3.1	CN(C)CCSc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2003.11.050
	CHEMBL161203	54716	0	None	54	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	244	4	0	4	3.1	CN(C)CCSc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2003.11.050
	90654687	110081	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	475	8	1	6	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235759	110081	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	475	8	1	6	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	145986031	165798	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248544	165798	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	118731361	118171	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	558	10	0	4	5.8	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409044	118171	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	558	10	0	4	5.8	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	139488527	169509	0	None	42	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	272	3	2	3	2.3	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4435235	169509	0	None	42	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	272	3	2	3	2.3	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	56660668	177076	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL4633326	177076	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	155561978	175802	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	518	8	1	6	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4584900	175802	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	518	8	1	6	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	42625445	186754	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL489028	186754	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.08.023
	21963826	76722	5	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	398	7	0	4	4.0	O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206747	76722	5	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	398	7	0	4	4.0	O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	118711997	114055	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2014.07.026
	CHEMBL3326986	114055	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2014.07.026
	122178707	121347	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581252	121347	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	25107649	187233	0	None	-1	3	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	CHEMBL492691	187233	0	None	-1	3	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	142601333	185739	0	None	36	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185739	0	None	36	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127051592	140853	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140853	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140853	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	44340897	9679	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	4	2.9	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL113192	9679	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	4	2.9	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1	10.1016/s0960-894x(02)00690-x
	164609650	184973	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4854456	184973	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	164611932	185178	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4857597	185178	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	127051592	140853	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140853	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140853	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	71602690	89658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376459	89658	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	53323185	56978	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	288	3	1	2	3.8	c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644268	56978	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	288	3	1	2	3.8	c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	44439397	91183	0	None	22	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	4	0	5	4.7	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL240021	91183	0	None	22	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	4	0	5	4.7	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2	10.1016/j.bmcl.2007.01.093
	11453751	90931	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	451	3	0	4	4.3	CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	CHEMBL239467	90931	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	451	3	0	4	4.3	CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	13069655	120581	0	None	-18	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3360992	120581	0	None	-18	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3546106	120581	0	None	-18	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	164608999	184360	0	None	-18	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4845741	184360	0	None	-18	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	71451454	81383	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	8	1	5	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159456	81383	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	8	1	5	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	71460456	81341	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	382	6	1	3	3.6	O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159318	81341	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	382	6	1	3	3.6	O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	127028152	138180	0	None	12	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	426	6	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3769836	138180	0	None	12	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	426	6	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	90654681	110075	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	454	7	1	4	3.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235753	110075	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	454	7	1	4	3.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.03.005
	11133795	203751	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	2	3	3.9	NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL68094	203751	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	2	3	3.9	NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	117209864	186010	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186010	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	164617626	185436	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4861794	185436	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	57402588	68397	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917347	68397	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	145992567	166752	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	548	8	2	5	4.4	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4283960	166752	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	548	8	2	5	4.4	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	25107519	187645	0	None	-17	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	CHEMBL495120	187645	0	None	-17	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	46233349	200276	5	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	244	4	0	3	1.8	CN(C)CCOc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	CHEMBL597356	200276	5	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	244	4	0	3	1.8	CN(C)CCOc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	129103318	167290	0	None	-309	14	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	167290	0	None	-309	14	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	117209864	186010	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186010	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	90656698	112581	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262431	112581	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302234	112581	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	43840296	150280	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	227	4	1	2	3.1	CNCc1cccc(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3952849	150280	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	227	4	1	2	3.1	CNCc1cccc(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	3303	2231	46	None	-338	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
	5311200	2231	46	None	-338	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
	CHEMBL267014	2231	46	None	-338	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
	46205045	124554	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640586	124554	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	46205045	124554	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640586	124554	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	57395598	68396	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917346	68396	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	145976722	163965	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	CHEMBL4208165	163965	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	136180319	117687	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	1	4	3.5	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401481	117687	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	1	4	3.5	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	60165418	75320	0	None	-281	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037521	75320	0	None	-281	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.ejmech.2012.03.042
	851853	191294	13	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	239	1	1	2	1.5	NC(=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5191370	191294	13	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	239	1	1	2	1.5	NC(=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	53320865	56992	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2	10.1016/j.bmcl.2010.11.078
	CHEMBL1644484	56992	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2	10.1016/j.bmcl.2010.11.078
	11341394	84643	0	None	2	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	2	4	3.7	NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222489	84643	0	None	2	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	2	4	3.7	NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	168290928	191832	0	None	-10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.3	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5199182	191832	0	None	-10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.3	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	162650168	180082	0	None	-389	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4748379	180082	0	None	-389	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	162651619	180287	0	None	-288	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4751063	180287	0	None	-288	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	44393052	65243	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	378	9	2	7	3.6	C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182840	65243	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	378	9	2	7	3.6	C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	58405183	110670	0	None	-4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	CHEMBL3260336	110670	0	None	-4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	209	3035	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	2113	3035	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	4748	3035	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	CHEMBL567	3035	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	DB00850	3035	97	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	44460725	105614	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	325	3	0	3	3.3	CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL312489	105614	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	325	3	0	3	3.3	CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	118626045	165644	0	None	-4	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4244691	165644	0	None	-4	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145947359	167631	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4171652	167631	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301757	167631	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	60196074	81787	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2ccccc2N2CCNCC2)nc1	10.1021/jm3003679
	CHEMBL2164340	81787	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2ccccc2N2CCNCC2)nc1	10.1021/jm3003679
	155537788	172327	0	None	16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	436	6	1	6	4.4	O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4475894	172327	0	None	16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	436	6	1	6	4.4	O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	117209965	185223	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185223	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601333	185739	0	None	36	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185739	0	None	36	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	164609650	184973	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4854456	184973	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	10593348	97266	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL26907	97266	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	134134210	143760	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	255	4	0	2	3.7	COc1ccccc1-c1cc(CN(C)C)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3901042	143760	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	255	4	0	2	3.7	COc1ccccc1-c1cc(CN(C)C)ccc1C	10.1016/j.ejmech.2016.07.029
	68281136	112028	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	422	7	1	7	2.8	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289950	112028	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	422	7	1	7	2.8	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	122178710	121350	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581255	121350	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	135458410	167165	0	None	-4	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL429136	167165	0	None	-4	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	117209965	185223	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185223	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	153287542	169510	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4435237	169510	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	109026957	171812	2	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	394	6	0	6	1.3	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4468683	171812	2	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	394	6	0	6	1.3	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2016.06.080
	132547276	142135	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	11	0	6	4.9	CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3883640	142135	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	11	0	6	4.9	CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmc.2016.12.039
	71061756	93090	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442997	93090	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061756	93090	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442997	93090	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	162666163	182357	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	10	0	6	6.7	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4785158	182357	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	10	0	6	6.7	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	11825129	48742	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	CHEMBL155861	48742	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	71061659	93091	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442998	93091	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061659	93091	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442998	93091	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	11059148	203890	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	434	7	1	5	4.1	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3	10.1021/jm0104264
	CHEMBL69040	203890	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	434	7	1	5	4.1	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3	10.1021/jm0104264
	118736365	118911	0	None	-32	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	7	1	10	1.4	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423329	118911	0	None	-32	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	7	1	10	1.4	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	2232766	161347	7	None	-42	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	297	7	0	2	4.9	c1ccc2c(OCCCCCN3CCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	CHEMBL4126145	161347	7	None	-42	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	297	7	0	2	4.9	c1ccc2c(OCCCCCN3CCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	155561581	175616	0	None	-9	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	6	-0.3	CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4580959	175616	0	None	-9	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	6	-0.3	CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	122483222	138082	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764889	138082	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765872	138082	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	127028154	138232	0	None	7	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770473	138232	0	None	7	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	168295269	192488	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	CHEMBL5209272	192488	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	162653993	183644	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4753809	183644	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802865	183644	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	122483222	138082	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764889	138082	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765872	138082	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	57390336	68390	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	10	1	4	2.9	NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917340	68390	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	10	1	4	2.9	NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	155514378	169826	0	None	-588	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12	10.1021/acsmedchemlett.6b00056
	CHEMBL4440130	169826	0	None	-588	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12	10.1021/acsmedchemlett.6b00056
	155559092	174765	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4561846	174765	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	71451456	81391	0	None	-31	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	3.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159463	81391	0	None	-31	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	3.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	59757163	106315	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092760	106315	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139189	106315	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	145985289	165683	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245607	165683	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	127037680	136868	0	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	442	8	1	5	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1039/C5MD00166H
	CHEMBL3742257	136868	0	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	442	8	1	5	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1039/C5MD00166H
	66801429	159703	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	6	2	3	4.5	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4104596	159703	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	6	2	3	4.5	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	44408813	74994	0	None	29	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	CHEMBL203400	74994	0	None	29	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	118709740	113505	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	348	7	0	2	4.2	O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321778	113505	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	348	7	0	2	4.2	O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	122178700	121279	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3580670	121279	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	122178705	121345	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581250	121345	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	11384146	201710	0	None	-60	9	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
	CHEMBL606556	201710	0	None	-60	9	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
	155566508	175780	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.6	COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4584464	175780	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.6	COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	164611932	185178	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4857597	185178	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	9996500	18337	1	None	-10	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	326	6	0	4	3.1	COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL1271151	18337	1	None	-10	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	326	6	0	4	3.1	COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1	10.1021/acs.jmedchem.7b01898
	136152964	194916	0	None	-8	8	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL541993	194916	0	None	-8	8	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	118524964	178111	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	243	2	0	1	3.8	CN(C)C1CCc2c(cccc2C2CCCC2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4648489	178111	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	243	2	0	1	3.8	CN(C)C1CCc2c(cccc2C2CCCC2)C1	10.1016/j.bmc.2019.115262
	66801561	156053	0	None	-794	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4062817	156053	0	None	-794	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	9856041	24082	3	None	-6606	8	Human	4.6	pKi	=	4.6	Binding	Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL133868	24082	3	None	-6606	8	Human	4.6	pKi	=	4.6	Binding	Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	60165545	75326	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	336	6	0	4	4.7	O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037527	75326	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	336	6	0	4	4.7	O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	90656707	110966	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	400	7	1	3	5.3	CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262426	110966	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	400	7	1	3	5.3	CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	168292233	191836	0	None	-34	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	4.2	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5199228	191836	0	None	-34	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	4.2	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	1346	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	280	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	9899402	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL9666	83	117	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	42618263	182465	1	None	-9	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	336	5	1	4	2.5	O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL478682	182465	1	None	-9	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	336	5	1	4	2.5	O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	155534184	171918	0	None	-162	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4470437	171918	0	None	-162	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	71457690	83769	0	None	-2	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205817	83769	0	None	-2	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	145965668	164090	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4209807	164090	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2	10.1016/j.bmcl.2018.06.019
	162650396	180061	0	None	-12	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4748107	180061	0	None	-12	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	155542237	173066	0	None	-117	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	472	7	2	6	5.2	COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4520003	173066	0	None	-117	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	472	7	2	6	5.2	COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	155514576	176526	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
	CHEMBL4441060	176526	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
	CHEMBL4597227	176526	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
	60165543	75318	0	None	-47	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	367	6	0	7	2.9	O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037519	75318	0	None	-47	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	367	6	0	7	2.9	O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	4407909	192842	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192842	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192842	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	58404615	124530	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640563	124530	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	58404615	124530	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640563	124530	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	CHEMBL5084249	214882	0	None	-3	8	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134144864	150664	0	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	600	15	1	7	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3955917	150664	0	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	600	15	1	7	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	155540807	172492	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4483554	172492	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	2756712	81779	87	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	CHEMBL2164331	81779	87	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	135398737	955	93	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	38	955	93	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	722	955	93	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	CHEMBL42	955	93	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	DB00363	955	93	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	155517162	170117	0	None	-16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	432	6	1	2	6.4	Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126769
	CHEMBL4444213	170117	0	None	-16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	432	6	1	2	6.4	Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126769
	134154069	154423	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3970299	154423	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990113	154423	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	57395086	71524	0	None	2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949966	71524	0	None	2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963029	71524	0	None	2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
	2220	3112	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	27400	3112	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	93	3112	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	CHEMBL294951	3112	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	DB06153	3112	82	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	11582132	65981	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL1836860	65981	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	66800823	112039	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	7	1	7	4.4	Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289961	112039	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	7	1	7	4.4	Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	23661594	90596	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL238808	90596	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	162670445	182850	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4791805	182850	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	44266267	207771	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	5	0	3	4.8	O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9615	207771	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	5	0	3	4.8	O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	49850672	56356	0	None	-100	9	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1631532	56356	0	None	-100	9	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	11729084	204173	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	0	2	5.2	CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32	10.1021/jm0104264
	CHEMBL70819	204173	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	0	2	5.2	CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32	10.1021/jm0104264
	10593348	97266	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL26907	97266	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL5084249	214882	0	None	-3	8	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	117209962	184845	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184845	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134154069	154423	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3970299	154423	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990113	154423	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	162654406	180556	0	None	-63	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4754193	180556	0	None	-63	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	179	399	115	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	2159	399	115	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	963	399	115	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	CHEMBL243712	399	115	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	DB06288	399	115	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	168293874	192155	0	None	-5	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192155	0	None	-5	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	24854186	95752	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL258593	95752	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24768520	92978	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244161	92978	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	46204422	124536	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640569	124536	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	46204422	124536	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640569	124536	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	134134456	143319	0	None	20	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	514	11	1	5	5.4	COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3897426	143319	0	None	20	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	514	11	1	5	5.4	COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	44341130	9616	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	5	2.2	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL112765	9616	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	5	2.2	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	162674732	183361	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	9	1	7	5.2	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4797980	183361	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	9	1	7	5.2	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	162651486	180245	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4750587	180245	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	10805599	99188	0	None	-13	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL281554	99188	0	None	-13	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	72550865	114053	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326984	114053	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.07.026
	53318219	56997	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	350	4	0	2	5.2	CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644489	56997	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	350	4	0	2	5.2	CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	42625356	186975	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL490644	186975	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	66801267	112058	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289979	112058	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	42618259	189710	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	442	6	0	6	3.9	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	CHEMBL515783	189710	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	442	6	0	6	3.9	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	44439401	91754	0	None	-12	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	4	0	5	3.6	COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241101	91754	0	None	-12	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	4	0	5	3.6	COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	11294248	167713	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL430280	167713	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	44401243	168470	0	None	-104	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL435301	168470	0	None	-104	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	11294248	167713	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL430280	167713	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	11294248	167713	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	CHEMBL430280	167713	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	168283304	191261	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	433	6	0	7	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5190746	191261	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	433	6	0	7	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	142601323	185817	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185817	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	122483235	138076	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763329	138076	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765849	138076	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	9890119	208034	0	None	-2511	7	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
	CHEMBL97596	208034	0	None	-2511	7	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
	6918647	100718	2	None	-501	14	Human	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL292759	100718	2	None	-501	14	Human	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	155534795	176227	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4471055	176227	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4594879	176227	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
	155534575	171922	0	None	-12	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	429	8	0	7	2.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4470487	171922	0	None	-12	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	429	8	0	7	2.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	142601323	185817	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185817	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	122483235	138076	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763329	138076	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765849	138076	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	90656675	110946	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	297	5	2	4	2.6	Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262404	110946	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	297	5	2	4	2.6	Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	44437333	91725	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	791	25	0	8	9.8	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL240944	91725	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	791	25	0	8	9.8	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	1296368	50791	16	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	458	5	2	5	6.0	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1	10.1016/j.bmcl.2015.03.049
	CHEMBL1576791	50791	16	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	458	5	2	5	6.0	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1	10.1016/j.bmcl.2015.03.049
	134152583	153153	0	None	10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3976948	153153	0	None	10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	162670926	183729	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4790694	183729	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803789	183729	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	18133518	164687	1	None	14	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4217334	164687	1	None	14	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	168284840	191272	0	None	-8	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	439	5	0	6	3.8	O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5190996	191272	0	None	-8	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	439	5	0	6	3.8	O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	134141355	154561	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3924565	154561	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991357	154561	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	134141355	154561	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3924565	154561	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991357	154561	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	44324603	111446	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	252	2	2	4	2.4	Cc1c(NC2=NCCN2)cccc1-c1cccnc1	10.1016/s0960-894x(02)00925-3
	CHEMBL327654	111446	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	252	2	2	4	2.4	Cc1c(NC2=NCCN2)cccc1-c1cccnc1	10.1016/s0960-894x(02)00925-3
	145965401	164022	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I	10.1021/acs.jmedchem.8b00828
	CHEMBL4208911	164022	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I	10.1021/acs.jmedchem.8b00828
	44437332	91557	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL240729	91557	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	134142259	145560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	2	5	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3915374	145560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	2	5	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1	10.1016/j.ejmech.2016.05.005
	127027387	137817	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	8	2	5	3.8	Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759948	137817	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	8	2	5	3.8	Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2015.11.040
	242	469	124	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	34	469	124	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	60795	469	124	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	CHEMBL1112	469	124	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	DB01238	469	124	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	25125376	177952	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646015	177952	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	4806	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	4806	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	7351	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	7351	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	9966051	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	9966051	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	CHEMBL2104993	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	CHEMBL2104993	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	DB09068	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	DB09068	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	54598063	154533	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL3979261	154533	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL3991129	154533	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
	4806	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	7351	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	9966051	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	CHEMBL2104993	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	DB09068	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	21048761	140281	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	7	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL380613	140281	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	7	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	424430	107602	5	None	60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	3	2	2	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL319005	107602	5	None	60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	3	2	2	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	46233352	200633	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	248	5	0	4	3.0	CN(C)CCSc1cccc(-c2ccoc2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL599612	200633	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	248	5	0	4	3.0	CN(C)CCSc1cccc(-c2ccoc2)n1	10.1016/j.bmc.2010.01.035
	4806	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	7351	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	9966051	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	CHEMBL2104993	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	DB09068	3977	88	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	23369421	181453	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	380	7	1	5	2.9	COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476463	181453	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	380	7	1	5	2.9	COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	71061750	104987	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113603	104987	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	72548115	114058	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326989	114058	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2014.07.026
	109027017	174376	2	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	378	5	0	4	2.5	O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4552394	174376	2	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	378	5	0	4	2.5	O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL5080305	214654	0	None	-4	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1cccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)c1	10.1021/acs.jmedchem.1c00497
	44324573	111502	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	285	2	2	3	3.7	Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL327906	111502	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	285	2	2	3	3.7	Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1	10.1016/s0960-894x(02)00925-3
	10521887	114343	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	351	6	0	5	3.2	O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331254	114343	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	351	6	0	5	3.2	O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	162672029	182881	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	8	1	7	5.0	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4792307	182881	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	8	1	7	5.0	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	11047201	52095	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	CHEMBL158770	52095	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	127051015	140849	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140849	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140849	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	162673636	183749	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4796041	183749	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4803955	183749	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	276	3487	50	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	5312149	3487	50	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	CHEMBL431298	3487	50	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	156010187	177090	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4633600	177090	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	20923078	117909	6	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	4	2	5	3.2	O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403339	117909	6	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	4	2	5	3.2	O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1	10.1016/j.bmcl.2015.03.049
	1353	1898	93	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	3559	1898	93	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	86	1898	93	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	CHEMBL54	1898	93	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	DB00502	1898	93	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	52952422	62562	0	None	12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	5	1	5	4.4	N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782809	62562	0	None	12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	5	1	5	4.4	N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	11329844	85130	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL225171	85130	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	127026144	137661	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	415	7	2	3	5.1	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758684	137661	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	415	7	2	3	5.1	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	1830	2572	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	207	2572	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	23897	2572	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	CHEMBL460	2572	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	DB01618	2572	44	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	134151428	154528	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3978642	154528	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3991094	154528	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	5216959	8578	4	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	363	8	2	5	2.6	OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl	10.1016/j.bmcl.2010.03.012
	CHEMBL1094908	8578	4	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	363	8	2	5	2.6	OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl	10.1016/j.bmcl.2010.03.012
	1816	2523	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	4205	2523	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	7241	2523	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	CHEMBL654	2523	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	DB00370	2523	102	None	-165	18	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	155562202	175794	0	None	-26	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4584719	175794	0	None	-26	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	888311	200659	46	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	243	4	0	2	2.4	CN(C)CCOc1ccccc1Br	10.1016/j.bmc.2010.01.035
	CHEMBL599818	200659	46	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	243	4	0	2	2.4	CN(C)CCOc1ccccc1Br	10.1016/j.bmc.2010.01.035
	22549784	117911	6	None	-2	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	418	4	0	4	4.9	COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403340	117911	6	None	-2	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	418	4	0	4	4.9	COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1	10.1016/j.bmcl.2015.03.049
	57393876	68388	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917338	68388	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	155536631	172196	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	CHEMBL4474014	172196	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	162653993	183644	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4753809	183644	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802865	183644	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	44424657	85732	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229179	85732	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	42618262	181547	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	486	9	0	7	4.4	COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476821	181547	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	486	9	0	7	4.4	COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	164619936	186185	0	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	415	7	0	7	1.6	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4873100	186185	0	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	415	7	0	7	1.6	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	71462064	81133	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	3	5.2	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158028	81133	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	3	5.2	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1	10.1016/j.ejmech.2012.07.043
	10740969	99058	0	None	-3	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	7	1	5	3.4	COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL28063	99058	0	None	-3	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	7	1	5	3.4	COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	155536631	172196	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	CHEMBL4474014	172196	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	452533	119988	5	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	265	5	0	5	2.9	CN(C)CCSc1nc(-c2ccncc2)cs1	10.1016/j.bmcl.2003.11.050
	CHEMBL350166	119988	5	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	265	5	0	5	2.9	CN(C)CCSc1nc(-c2ccncc2)cs1	10.1016/j.bmcl.2003.11.050
	122181252	121830	0	None	-2	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	452	6	1	4	3.6	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3589978	121830	0	None	-2	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	452	6	1	4	3.6	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	76325349	106390	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121436	106390	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139519	106390	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	127026120	137781	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	9	1	5	3.4	CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759651	137781	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	9	1	5	3.4	CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	134131976	144950	0	None	34	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	509	10	1	5	5.2	N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3910730	144950	0	None	34	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	509	10	1	5	5.2	N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	71449549	81138	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	11	1	6	3.9	COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158033	81138	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	11	1	6	3.9	COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1	10.1016/j.ejmech.2012.07.043
	71462179	81400	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	5	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159472	81400	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	5	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	71574304	86236	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312638	86236	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12	10.1016/j.ejmech.2012.11.042
	117209962	184845	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184845	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	156020705	178053	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	328	2	1	3	2.8	CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4647589	178053	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	328	2	1	3	2.8	CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	2726	916	68	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	621	916	68	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	83	916	68	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	CHEMBL71	916	68	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	DB00477	916	68	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	127051015	140849	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140849	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140849	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	9865858	163281	0	None	-16	8	Rat	7.6	pKi	=	7.6	Binding	The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	402	6	1	5	4.0	COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1	10.1021/jm9910122
	CHEMBL418854	163281	0	None	-16	8	Rat	7.6	pKi	=	7.6	Binding	The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	402	6	1	5	4.0	COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1	10.1021/jm9910122
	10355252	15000	0	None	2	3	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL120927	15000	0	None	2	3	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	44266253	98130	1	None	35	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273821	98130	1	None	35	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	44324325	107130	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1	10.1016/s0960-894x(02)00925-3
	CHEMBL316283	107130	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1	10.1016/s0960-894x(02)00925-3
	10683945	98016	0	None	6	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O	10.1021/jm9911433
	CHEMBL27309	98016	0	None	6	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O	10.1021/jm9911433
	155558563	174735	0	None	-13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	402	6	1	5	3.8	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4561000	174735	0	None	-13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	402	6	1	5	3.8	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	23111951	68384	10	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	330	6	1	3	2.4	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917334	68384	10	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	330	6	1	3	2.4	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	68281137	112053	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	9	1	7	3.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289974	112053	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	9	1	7	3.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	168284109	190723	0	None	-151	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	420	7	0	7	2.3	COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1	10.1016/j.ejmech.2022.114193
	CHEMBL5182877	190723	0	None	-151	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	420	7	0	7	2.3	COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1	10.1016/j.ejmech.2022.114193
	44408998	140367	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	6	0	3	3.6	O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL380863	140367	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	6	0	3	3.6	O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1	10.1016/j.bmcl.2005.11.067
	44439402	169354	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	2	1	2	3.4	OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL442093	169354	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	2	1	2	3.4	OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	168279047	191161	0	None	-269	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	437	8	0	8	2.7	O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5189101	191161	0	None	-269	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	437	8	0	8	2.7	O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	53323187	56988	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644278	56988	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	58405225	110672	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	323	6	1	6	2.8	CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1	10.1021/ml500082j
	CHEMBL3260338	110672	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	323	6	1	6	2.8	CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1	10.1021/ml500082j
	155538144	172372	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	295	3	1	3	4.0	CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4476520	172372	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	295	3	1	3	4.0	CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	164617626	185436	0	None	-9	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4861794	185436	0	None	-9	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	155565813	175784	0	None	-1380	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4584504	175784	0	None	-1380	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	145975992	163492	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	393	4	1	3	3.6	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4202520	163492	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	393	4	1	3	3.6	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	164608999	184360	0	None	-18	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4845741	184360	0	None	-18	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	71602640	89653	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376450	89653	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	52952424	62565	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	360	5	1	5	3.1	OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782812	62565	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	360	5	1	5	3.1	OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	45268647	196222	0	None	64	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	414	7	3	3	3.1	Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL561750	196222	0	None	64	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	414	7	3	3	3.1	Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	71449627	81330	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	4	4.7	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159307	81330	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	4	4.7	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	53377238	66344	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851686	66344	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216945	66344	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	134131283	142119	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	8	0	5	4.3	Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	CHEMBL3883517	142119	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	8	0	5	4.3	Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	71602640	89653	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376450	89653	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	155552311	174017	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4543646	174017	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	155539605	172821	0	None	-12	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4514672	172821	0	None	-12	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	168291617	192011	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	413	8	0	6	3.5	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5202054	192011	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	413	8	0	6	3.5	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	24768525	143896	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL390213	143896	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	145961372	161583	0	None	-128	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	CHEMBL4129589	161583	0	None	-128	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	90654688	110082	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	489	9	1	6	3.3	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235760	110082	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	489	9	1	6	3.3	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	127042540	137098	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747744	137098	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	71449645	81418	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159490	81418	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	25125375	177812	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	281	3	0	2	3.8	COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1	10.1016/j.bmc.2019.115262
	CHEMBL4644005	177812	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	281	3	0	2	3.8	COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1	10.1016/j.bmc.2019.115262
	127040761	136800	0	None	13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1	10.1039/C5MD00166H
	CHEMBL3741657	136800	0	None	13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1	10.1039/C5MD00166H
	24873384	182577	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4788223	182577	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	118709739	113504	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	334	6	0	2	3.8	O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321777	113504	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	334	6	0	2	3.8	O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	122178703	121343	0	None	1	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581248	121343	0	None	1	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	162646653	179478	0	None	-18	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4741142	179478	0	None	-18	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	44324536	206819	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	269	2	2	3	3.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL90538	206819	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	269	2	2	3	3.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1	10.1016/s0960-894x(02)00925-3
	11785077	85138	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL225252	85138	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	44437332	91557	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL240729	91557	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	11143090	52183	1	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	9	0	4	4.3	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	CHEMBL158850	52183	1	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	9	0	4	4.3	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	44437328	90953	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239656	90953	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	142601343	185579	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185579	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	160510	101100	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
	CHEMBL1506260	101100	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
	CHEMBL295234	101100	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
	160510	101100	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1021/acs.jmedchem.0c01887
	CHEMBL1506260	101100	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1021/acs.jmedchem.0c01887
	CHEMBL295234	101100	40	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1021/acs.jmedchem.0c01887
	155511929	176253	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4436319	176253	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595069	176253	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	13069603	120582	0	None	-15	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360993	120582	0	None	-15	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546107	120582	0	None	-15	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	168281754	190880	0	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	434	6	0	8	2.7	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5185101	190880	0	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	434	6	0	8	2.7	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	122483218	138087	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764418	138087	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765877	138087	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	57390695	70438	0	None	-21	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946257	70438	0	None	-21	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	24768518	92810	0	None	-46	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243743	92810	0	None	-46	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	122483218	138087	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764418	138087	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765877	138087	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	76328890	106391	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121414	106391	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139522	106391	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
	44347445	16260	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL122485	16260	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	145972025	164455	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	409	4	1	3	4.1	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4214208	164455	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	409	4	1	3	4.1	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	127026142	137731	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	384	7	1	3	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759273	137731	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	384	7	1	3	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	155524957	176321	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4455845	176321	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595569	176321	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	127049061	140742	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818398	140742	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	44582708	186814	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	CHEMBL489408	186814	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	155554462	174577	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	316	4	1	7	1.5	CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4557247	174577	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	316	4	1	7	1.5	CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	44460759	104199	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	275	3	0	3	2.4	CN1CCCN(CCn2ccc3ccc(F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL309908	104199	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	275	3	0	3	2.4	CN1CCCN(CCn2ccc3ccc(F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	127049061	140742	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818398	140742	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	162663279	183694	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4779939	183694	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803352	183694	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	156013588	177177	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	353	3	2	4	2.9	COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4635229	177177	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	353	3	2	4	2.9	COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	9817810	17340	1	None	-12	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL125745	17340	1	None	-12	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	137652310	157226	0	None	4	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4076525	157226	0	None	4	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	57399092	68405	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	468	9	0	6	3.5	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917355	68405	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	468	9	0	6	3.5	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	145969402	164794	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4218625	164794	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	71451457	81398	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	394	8	1	5	3.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159470	81398	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	394	8	1	5	3.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1	10.1016/j.ejmech.2012.07.043
	155543250	173275	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	275	1	1	2	3.3	Cn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4526012	173275	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	275	1	1	2	3.3	Cn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	142601343	185579	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185579	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	56944955	159667	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	CHEMBL4104216	159667	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	118706284	120498	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310112	120498	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545440	120498	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	118709753	113517	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	326	5	0	2	3.9	O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321795	113517	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	326	5	0	2	3.9	O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	66801335	112026	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	8	1	7	3.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289948	112026	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	8	1	7	3.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	109026956	173404	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	393	6	0	5	1.9	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4528701	173404	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	393	6	0	5	1.9	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2016.06.080
	11102049	103345	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	6	2	3	4.9	COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3	10.1021/jm0104264
	CHEMBL308461	103345	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	6	2	3	4.9	COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3	10.1021/jm0104264
	162649235	180050	0	None	-46	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4747978	180050	0	None	-46	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	9921064	127152	25	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	CHEMBL365751	127152	25	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	145964154	164296	0	None	7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl	10.1021/acs.jmedchem.8b00828
	CHEMBL4212339	164296	0	None	7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl	10.1021/acs.jmedchem.8b00828
	53317861	56990	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	318	4	1	3	3.9	COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644280	56990	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	318	4	1	3	3.9	COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	155549315	173805	0	None	-144	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	448	9	0	6	4.1	COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4538667	173805	0	None	-144	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	448	9	0	6	4.1	COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1	10.1016/j.bmcl.2019.06.029
	155519599	176289	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4447594	176289	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595274	176289	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	10611439	96744	0	None	-2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	261	0	0	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O	10.1021/jm9911433
	CHEMBL26471	96744	0	None	-2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	261	0	0	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O	10.1021/jm9911433
	57401706	70142	0	None	-50	11	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	CHEMBL1940419	70142	0	None	-50	11	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	60165681	75327	0	None	-102	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037528	75327	0	None	-102	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	127027715	137654	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	452	7	0	4	4.0	O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758619	137654	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	452	7	0	4	4.0	O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	71455001	81410	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159482	81410	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	142601341	185348	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185348	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	9904281	47719	28	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	CHEMBL1548	47719	28	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	13069626	120579	0	None	-295	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3361000	120579	0	None	-295	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3546103	120579	0	None	-295	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	90654682	110076	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	7	1	4	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235754	110076	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	7	1	4	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	71602688	89656	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376457	89656	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	142601341	185348	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185348	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	11560285	68386	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917336	68386	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12	10.1016/j.bmc.2011.09.044
	53377241	66616	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1852852	66616	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216488	66616	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	25107717	187526	1	None	-6	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	CHEMBL494512	187526	1	None	-6	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	42618260	181526	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	458	7	0	7	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476615	181526	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	458	7	0	7	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	417052	116829	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1016/j.bmcl.2003.09.027
	CHEMBL338115	116829	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1016/j.bmcl.2003.09.027
	71602688	89656	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376457	89656	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	155514889	169888	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	520	10	1	8	3.3	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4440973	169888	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	520	10	1	8	3.3	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	11283795	142015	0	None	3	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	483	9	1	5	4.0	CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL387738	142015	0	None	3	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	483	9	1	5	4.0	CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	56850390	71455	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926733	71455	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962486	71455	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	46204421	124535	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	CHEMBL3640568	124535	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	46206021	124575	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640607	124575	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	46204421	124535	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	CHEMBL3640568	124535	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	46206021	124575	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640607	124575	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	90469115	185818	4	None	-1000	17	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	CHEMBL4867565	185818	4	None	-1000	17	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	10154897	65233	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.ejmech.2019.111705
	CHEMBL182797	65233	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.ejmech.2019.111705
	86288948	112599	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3233679	112599	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3302600	112599	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
	44393228	64768	1	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL181950	64768	1	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	12088080	64850	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182174	64850	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	44393069	66061	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	8	2	6	3.5	C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL183862	66061	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	8	2	6	3.5	C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	11151899	2124	13	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
	8432	2124	13	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
	CHEMBL4205783	2124	13	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
	9863250	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030030n
	CHEMBL12624	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030030n
	9885982	104157	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	CHEMBL309750	104157	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	9885982	104157	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL309750	104157	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	9863250	17963	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm049743b
	CHEMBL12624	17963	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm049743b
	118626121	165396	0	None	1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238479	165396	0	None	1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983961	165401	0	None	-3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238679	165401	0	None	-3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	86288948	112599	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233679	112599	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302600	112599	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
	145990353	166774	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1	10.1039/C8MD00168E
	CHEMBL4284331	166774	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1	10.1039/C8MD00168E
	145988738	167201	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4292237	167201	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	276	3487	50	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
	5312149	3487	50	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
	CHEMBL431298	3487	50	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
	10495891	99076	0	None	6	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL280804	99076	0	None	6	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	90656710	110950	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	310	6	1	3	3.5	Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262410	110950	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	310	6	1	3	3.5	Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	9863250	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL12624	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.7b01898
	5	139	72	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	5202	139	72	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	CHEMBL39	139	72	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	DB08839	139	72	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	44364048	39109	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	262	6	3	3	2.3	NCCCC1(CCCN)CCc2cccc(O)c2C1	10.1021/jm0341204
	CHEMBL146942	39109	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	262	6	3	3	2.3	NCCCC1(CCCN)CCc2cccc(O)c2C1	10.1021/jm0341204
	9863250	17963	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/s0960-894x(00)00166-9
	CHEMBL12624	17963	6	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/s0960-894x(00)00166-9
	9863250	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	CHEMBL12624	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	9863250	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	CHEMBL12624	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	10500557	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL12427	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10500557	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	CHEMBL12427	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	9863250	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/j.ejmech.2019.111705
	CHEMBL12624	17963	6	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/j.ejmech.2019.111705
	2389	3306	118	None	-7	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	5073	3306	118	None	-7	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	96	3306	118	None	-7	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	CHEMBL85	3306	118	None	-7	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	DB00734	3306	118	None	-7	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	10028436	3506	5	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
	3237	3506	5	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
	CHEMBL95104	3506	5	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
	145977297	163610	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	350	4	1	3	3.8	OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2017.11.007
	CHEMBL4203932	163610	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	350	4	1	3	3.8	OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2017.11.007
	66801230	112029	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	436	8	1	7	3.2	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289951	112029	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	436	8	1	7	3.2	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	56943600	112088	0	None	-5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	8	1	5	5.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3290008	112088	0	None	-5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	8	1	5	5.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	66801186	112098	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	7	3.2	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3290018	112098	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	7	3.2	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	155545402	173365	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells	ChEMBL	391	6	1	3	3.8	O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32	10.1016/j.ejmech.2019.111690
	CHEMBL4527987	173365	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells	ChEMBL	391	6	1	3	3.8	O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32	10.1016/j.ejmech.2019.111690
	11536844	115096	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	115096	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	145987771	167065	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4289783	167065	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.ejmech.2017.12.063
	44276598	95654	0	None	-1	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0108505
	CHEMBL25815	95654	0	None	-1	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0108505
	8431	1472	9	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
	9843179	1472	9	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
	CHEMBL69257	1472	9	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
	10500557	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL12427	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	10500557	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL12427	16648	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	10825325	99396	0	None	1	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL282863	99396	0	None	1	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	11267988	66799	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	CHEMBL186112	66799	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	11186985	123820	0	None	-3	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	CHEMBL362540	123820	0	None	-3	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	23369416	182463	2	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL478680	182463	2	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	66801379	112044	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	8	3.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289966	112044	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	8	3.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	24854267	157877	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	385	6	1	3	4.0	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm070279v
	CHEMBL408426	157877	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	385	6	1	3	4.0	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm070279v
	155512409	169620	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	6	0	6	4.3	Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	CHEMBL4437217	169620	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	6	0	6	4.3	Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	155546781	173604	0	None	36	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2	10.1016/j.ejmech.2019.111705
	CHEMBL4533865	173604	0	None	36	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2	10.1016/j.ejmech.2019.111705
	11025847	163284	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL418888	163284	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	11025847	163284	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL418888	163284	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1021/jm0104264
	9956365	195495	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL553794	195495	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	91864602	140713	0	None	2	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140713	0	None	2	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	9956365	195495	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm070279v
	CHEMBL553794	195495	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm070279v
	91864602	140713	0	None	2	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140713	0	None	2	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	11016205	204745	1	None	-2	5	Human	8.4	pKi	=	8.4	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	CHEMBL74756	204745	1	None	-2	5	Human	8.4	pKi	=	8.4	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	11978813	718	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	5014	718	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	7672	718	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	CHEMBL2105760	718	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	DB09128	718	79	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	4106	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	5358812	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	89	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	CHEMBL93240	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	24854044	97270	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	CHEMBL269083	97270	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	46196448	124516	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640550	124516	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	11725453	99052	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	CHEMBL28056	99052	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	46196448	124516	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640550	124516	1	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	11725453	99052	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL28056	99052	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	11725453	99052	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL28056	99052	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	11725453	99052	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0498102
	CHEMBL28056	99052	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0498102
	66800942	112018	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	416	6	1	6	2.7	Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289708	112018	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	416	6	1	6	2.7	Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	11465618	102371	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL3039528	102371	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL5191141	102371	23	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	10811746	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL273246	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	10811746	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	CHEMBL273246	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	25107648	187199	0	None	25	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	CHEMBL492480	187199	0	None	25	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	76284724	104977	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	490	11	1	5	4.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113593	104977	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	490	11	1	5	4.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	11047374	18877	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL12846	18877	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	10835110	114562	0	None	79	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
	CHEMBL333784	114562	0	None	79	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
	44368732	46118	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	CHEMBL153398	46118	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	11725453	99052	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL28056	99052	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	10811746	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL273246	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	10811746	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	CHEMBL273246	98042	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	162656718	180934	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	CHEMBL4758402	180934	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	4106	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	5358812	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	89	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	CHEMBL93240	2485	22	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	145	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	1832	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	CHEMBL7257	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	DB14010	140	49	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	398712	77840	5	None	-30	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	CHEMBL209324	77840	5	None	-30	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	122483281	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL5083607	214850	0	None	-2	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	71574212	86255	0	None	-3	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312935	86255	0	None	-3	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	118731349	118160	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	3.5	CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409033	118160	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	3.5	CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	118731359	118169	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	532	10	0	5	4.3	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409042	118169	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	532	10	0	5	4.3	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	156014079	177232	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12	10.1016/j.bmc.2020.115459
	CHEMBL4636031	177232	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12	10.1016/j.bmc.2020.115459
	138691338	163643	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4204595	163643	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1016/j.ejmech.2019.03.017
	11425677	182311	0	None	-1	4	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784424	182311	0	None	-1	4	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	138691338	163643	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.7b01898
	CHEMBL4204595	163643	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.7b01898
	90656694	110968	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262428	110968	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	10171	57	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
	272	57	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
	CHEMBL274384	57	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
	122483281	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	67268994	163944	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	118736368	118914	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	527	7	1	10	2.7	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423332	118914	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	527	7	1	10	2.7	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	11786227	172581	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	CHEMBL449089	172581	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	118728510	117679	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	5	4.1	Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401473	117679	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	5	4.1	Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL5083607	214850	0	None	-2	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	122483281	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	138083	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	12	1541	17	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
	6918513	1541	17	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
	CHEMBL267615	1541	17	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
	162671716	183738	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4792591	183738	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803839	183738	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	44439405	91783	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	440	4	0	5	5.3	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL241282	91783	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	440	4	0	5	5.3	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2	10.1016/j.bmcl.2007.01.093
	417052	116829	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1021/acs.jmedchem.0c01887
	CHEMBL338115	116829	43	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1021/acs.jmedchem.0c01887
	72711487	102567	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
	CHEMBL2431040	102567	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
	CHEMBL3040890	102567	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
	57399088	68387	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917337	68387	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	90654676	110070	0	None	-25	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	464	9	1	5	2.8	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235748	110070	0	None	-25	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	464	9	1	5	2.8	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	138691366	174934	0	None	7	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2ccc(F)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4565881	174934	0	None	7	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2ccc(F)cc12	10.1016/j.ejmech.2019.03.017
	145946733	167556	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	CHEMBL4205526	167556	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300710	167556	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	173	3238	95	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
	5011	3238	95	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
	CHEMBL18772	3238	95	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
	1355	1998	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	142	1998	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	CHEMBL478	1998	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	DB12110	1998	88	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	134144798	150223	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	325	5	0	3	4.6	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3952371	150223	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	325	5	0	3	4.6	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	118728521	117690	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401484	117690	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	156019563	177963	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	364	5	0	4	4.1	C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4646172	177963	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	364	5	0	4	4.1	C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	71602691	89659	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376460	89659	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	122483260	138075	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763275	138075	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765848	138075	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	11121216	30108	0	None	-15	14	Human	7.5	pKi	=	7.5	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL138989	30108	0	None	-15	14	Human	7.5	pKi	=	7.5	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	88912137	110671	0	None	19	4	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	CHEMBL3260337	110671	0	None	19	4	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	44460471	205562	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81424	205562	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	145986138	165445	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239705	165445	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	71574302	86235	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312637	86235	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	71574208	86240	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312642	86240	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	156019543	177912	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2020.115459
	CHEMBL4645525	177912	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2020.115459
	90654854	112656	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233676	112656	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304183	112656	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
	156009483	177042	0	None	7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	412	5	1	5	2.8	C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4632872	177042	0	None	7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	412	5	1	5	2.8	C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	42618272	91170	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.6	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239898	91170	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.6	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	25107517	187232	0	None	-1	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL492690	187232	0	None	-1	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	72551082	114054	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326985	114054	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.07.026
	11168662	84603	0	None	-1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	CHEMBL222262	84603	0	None	-1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
	281	3484	28	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
	5312148	3484	28	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
	CHEMBL12264	3484	28	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
	3233	3486	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	3247	3486	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	6604889	3486	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	CHEMBL282199	3486	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	DB13988	3486	44	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	9820952	18706	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm970519e
	CHEMBL12777	18706	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm970519e
	10715573	98463	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm970519e
	CHEMBL275996	98463	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm970519e
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
	9820952	18706	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12777	18706	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1016/s0960-894x(00)00166-9
	10715573	98463	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL275996	98463	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00166-9
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	44368358	119646	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	CHEMBL347115	119646	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	44368306	164865	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	391	6	0	3	4.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	CHEMBL422146	164865	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	391	6	0	3	4.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	142601337	185946	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185946	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	162674561	183247	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	CHEMBL4796647	183247	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	10171	57	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
	272	57	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
	CHEMBL274384	57	18	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
	67268994	163944	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	2726	916	68	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	621	916	68	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	83	916	68	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	CHEMBL71	916	68	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	DB00477	916	68	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	44324627	206742	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1ccsc1	10.1016/s0960-894x(02)00925-3
	CHEMBL90118	206742	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1ccsc1	10.1016/s0960-894x(02)00925-3
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	57403839	71517	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949967	71517	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963008	71517	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	90656708	110967	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	415	8	1	4	5.5	CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262427	110967	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	415	8	1	4	5.5	CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	46205699	124568	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	CHEMBL3640600	124568	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	46205699	124568	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	CHEMBL3640600	124568	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	71449550	81139	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	9	1	4	4.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158034	81139	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	9	1	4	4.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1016/j.ejmech.2012.07.043
	71602691	89659	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376460	89659	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	156014279	177206	0	None	-20	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	348	5	1	2	5.0	CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4635676	177206	0	None	-20	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	348	5	1	2	5.0	CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3	10.1016/j.bmc.2020.115578
	122483260	138075	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763275	138075	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765848	138075	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	145973487	164596	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4216022	164596	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	127052486	140798	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819153	140798	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	90654698	110057	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235735	110057	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.03.005
	145947944	167707	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4208428	167707	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302764	167707	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
	155511262	169520	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4435528	169520	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	11151899	2124	13	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
	8432	2124	13	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
	CHEMBL4205783	2124	13	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
	135367959	164586	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215925	164586	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	1353	1898	93	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	3559	1898	93	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	86	1898	93	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	CHEMBL54	1898	93	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	DB00502	1898	93	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	127052486	140798	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819153	140798	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	145947088	167600	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4208181	167600	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4301443	167600	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	6918648	101532	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL29846	101532	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	6918648	101532	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	CHEMBL29846	101532	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	76314436	106240	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3121415	106240	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3139010	106240	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	19958494	99425	1	None	-9	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	360	3	1	3	3.9	FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL283036	99425	1	None	-9	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	360	3	1	3	3.9	FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	122187	3676	17	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
	61	3676	17	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
	CHEMBL22778	3676	17	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
	18133517	164398	0	None	16	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4213576	164398	0	None	16	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	127027391	137807	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	7	0	4	4.5	O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759885	137807	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	7	0	4	4.5	O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	162672202	183740	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4790910	183740	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803865	183740	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	135367959	164586	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215925	164586	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
	44268087	20162	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	CHEMBL13049	20162	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
	145983794	165630	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4244280	165630	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	134137332	142983	0	None	12	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3894679	142983	0	None	12	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	145976890	163793	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	8	1	4	5.2	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4206203	163793	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	8	1	4	5.2	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.bmc.2017.03.057
	145974189	164602	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4216126	164602	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	142601337	185946	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185946	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	137654666	158592	0	None	-44	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4092243	158592	0	None	-44	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	10667433	148774	0	None	6	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.2	COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	CHEMBL394080	148774	0	None	6	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.2	COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	72547878	114057	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	517	12	1	6	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326988	114057	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	517	12	1	6	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1	10.1016/j.bmc.2014.07.026
	155568373	176070	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4591320	176070	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	25107515	187336	0	None	-16	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL493305	187336	0	None	-16	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	155568246	176076	0	None	-138	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	528	9	2	5	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4591440	176076	0	None	-138	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	528	9	2	5	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	44374227	168340	2	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1ncc(-c2ccccc2)s1	10.1016/j.bmcl.2003.11.050
	CHEMBL434477	168340	2	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1ncc(-c2ccccc2)s1	10.1016/j.bmcl.2003.11.050
	16117279	60106	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1642886	60106	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1739606	60106	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	121209051	164364	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4213135	164364	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	162643049	183589	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4776078	183589	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4802282	183589	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	121209051	164364	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4213135	164364	5	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134130846	142265	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3885178	142265	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	11948707	166143	0	None	-158	13	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	CHEMBL426317	166143	0	None	-158	13	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	53377237	66359	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851771	66359	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3215834	66359	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
	162661942	183687	3	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4778949	183687	3	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803285	183687	3	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	44424656	85726	0	None	-1	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229124	85726	0	None	-1	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	162668661	183717	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4789408	183717	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803658	183717	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	71462067	81140	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	460	9	1	4	5.7	CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158035	81140	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	460	9	1	4	5.7	CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2012.07.043
	60165416	75267	0	None	-83	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037431	75267	0	None	-83	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	71459954	79153	0	None	-331	7	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
	CHEMBL2113386	79153	0	None	-331	7	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
	46206020	124574	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640606	124574	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	46206020	124574	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640606	124574	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	155541866	173025	0	None	-95	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4519266	173025	0	None	-95	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	44393114	63606	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL180087	63606	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	76336177	106244	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121412	106244	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139015	106244	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	57399093	68410	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	443	9	0	4	4.9	CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917360	68410	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	443	9	0	4	4.9	CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	132938109	164279	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	500	9	2	5	4.2	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	CHEMBL4212199	164279	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	500	9	2	5	4.2	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	156019750	177991	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646587	177991	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	11666595	120506	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310115	120506	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545467	120506	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	56945045	112034	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	8	1	6	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289956	112034	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	8	1	6	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	135458393	155572	4	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL404511	155572	4	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	24854108	157884	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	391	7	0	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21	10.1021/jm070279v
	CHEMBL408429	157884	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	391	7	0	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21	10.1021/jm070279v
	76335863	104982	0	None	22	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	487	11	1	5	4.5	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113598	104982	0	None	22	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	487	11	1	5	4.5	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1	10.1016/j.bmc.2014.01.016
	46203753	124518	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	CHEMBL3640552	124518	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	12741421	206736	8	None	-22	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	CHEMBL90053	206736	8	None	-22	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	46203753	124518	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	CHEMBL3640552	124518	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	24841480	183875	0	None	-165	20	Human	6.5	pKi	=	6.5	Binding	Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183875	0	None	-165	20	Human	6.5	pKi	=	6.5	Binding	Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	127052465	140706	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140706	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	145977799	163619	0	None	-4	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204036	163619	0	None	-4	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	162669562	182678	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4789472	182678	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	127052465	140706	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140706	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL4748908	214012	1	None	-3	12	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
	90656716	112686	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262401	112686	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304495	112686	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
	57393877	68400	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	5	3.4	O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917350	68400	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	5	3.4	O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.09.044
	71458516	81136	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	465	8	1	4	5.4	O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158031	81136	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	465	8	1	4	5.4	O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	57396857	71539	0	None	6	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949971	71539	0	None	6	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963101	71539	0	None	6	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL4748908	214012	1	None	-3	12	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
	57390335	68389	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	9	1	4	2.5	NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917339	68389	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	9	1	4	2.5	NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	162669562	182678	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4789472	182678	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	57403841	71525	0	None	4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949968	71525	0	None	4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963030	71525	0	None	4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	42618273	91171	0	None	-223	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	461	3	0	4	4.1	O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239899	91171	0	None	-223	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	461	3	0	4	4.1	O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	10020040	99940	0	None	-72	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	338	4	1	4	3.6	CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL28651	99940	0	None	-72	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	338	4	1	4	3.6	CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	136118653	93025	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442267	93025	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	155544811	176527	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4567345	176527	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4597228	176527	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	60165411	75328	0	None	-93	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	381	7	0	7	3.3	O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037529	75328	0	None	-93	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	381	7	0	7	3.3	O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	71460454	81335	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	411	9	2	5	2.9	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159312	81335	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	411	9	2	5	2.9	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1	10.1016/j.ejmech.2012.07.043
	24768522	142551	0	None	2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL389110	142551	0	None	2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	12741423	107037	11	None	-120	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	CHEMBL315684	107037	11	None	-120	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	56852956	112016	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	112016	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	44517733	195189	0	None	30	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	431	7	3	5	1.6	COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL550740	195189	0	None	30	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	431	7	3	5	1.6	COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1	10.1016/j.bmcl.2009.06.038
	162648426	179936	0	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	373	6	0	3	4.6	Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4746695	179936	0	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	373	6	0	3	4.6	Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1	10.1016/j.bmc.2020.115943
	168299277	192671	0	None	281	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	404	8	0	5	4.2	CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	CHEMBL5219333	192671	0	None	281	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	404	8	0	5	4.2	CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	44460738	105426	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	291	3	0	3	2.9	CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL312049	105426	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	291	3	0	3	2.9	CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1	10.1016/s0960-894x(02)00438-9
	76332579	106248	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121423	106248	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139019	106248	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	145976618	163755	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	8	1	4	4.7	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4205806	163755	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	8	1	4	4.7	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	90654836	112667	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233667	112667	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304308	112667	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	155557134	174513	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	493	10	0	5	5.1	CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4555890	174513	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	493	10	0	5	5.1	CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	11186985	123820	0	None	-11	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL362540	123820	0	None	-11	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	134141985	147151	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	147151	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	66801673	112047	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289969	112047	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	66801251	112093	0	None	-13	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	507	7	1	6	5.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3290013	112093	0	None	-13	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	507	7	1	6	5.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	122178704	121344	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581249	121344	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	44401106	124301	0	None	-52	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL363581	124301	0	None	-52	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	76284452	104978	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	492	11	1	6	3.7	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113594	104978	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	492	11	1	6	3.7	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	46204423	124537	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640570	124537	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	46204423	124537	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640570	124537	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	72550200	114049	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326980	114049	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1	10.1016/j.bmc.2014.07.026
	72550423	114050	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326981	114050	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.07.026
	25107651	187686	0	None	-4	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	CHEMBL495321	187686	0	None	-4	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	44448054	94756	0	None	-6	6	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL253318	94756	0	None	-6	6	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	56852956	112016	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	112016	1	None	-87	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	44404394	132790	0	None	-30	7	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	CHEMBL370128	132790	0	None	-30	7	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	168290061	191310	0	None	-69	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	424	8	3	8	2.7	Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5191557	191310	0	None	-69	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	424	8	3	8	2.7	Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	162643558	183592	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4777499	183592	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4802310	183592	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	127026119	137710	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	8	1	5	2.7	COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759120	137710	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	8	1	5	2.7	COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	155562834	175182	0	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	450	8	0	5	4.1	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4571077	175182	0	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	450	8	0	5	4.1	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	72198011	89816	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL2377591	89816	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	72198011	89816	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377591	89816	0	None	-158	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	13069622	120590	0	None	-31	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360999	120590	0	None	-31	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546120	120590	0	None	-31	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	168276829	190101	0	None	-32	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5173329	190101	0	None	-32	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	117209918	186386	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186386	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	155534153	176226	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4469860	176226	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4594878	176226	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	117209918	186386	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186386	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	168279625	190983	0	None	-66	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	433	5	0	6	3.5	O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5186688	190983	0	None	-66	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	433	5	0	6	3.5	O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	71461049	82946	0	None	-204	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181187	82946	0	None	-204	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	118626208	165529	0	None	-57	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241830	165529	0	None	-57	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	5640104	117913	11	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	429	4	1	5	3.4	NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403342	117913	11	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	429	4	1	5	3.4	NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1	10.1016/j.bmcl.2015.03.049
	74538690	143039	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	511	10	1	4	5.2	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3895172	143039	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	511	10	1	4	5.2	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	164625711	186308	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4874914	186308	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
	155535827	172093	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	450	6	1	2	6.5	Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.bmcl.2019.126769
	CHEMBL4472767	172093	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	450	6	1	2	6.5	Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.bmcl.2019.126769
	11278059	56985	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	302	3	1	2	4.2	Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644275	56985	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	302	3	1	2	4.2	Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	44439393	91780	0	None	2754	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241279	91780	0	None	2754	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	44421337	138102	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL376662	138102	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1016/j.ejmech.2020.112437
	44421337	138102	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL376662	138102	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	44401105	69547	0	None	-3	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193435	69547	0	None	-3	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
	132547277	142121	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3883542	142121	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	44324640	207399	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL94017	207399	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	60165535	75321	0	None	-6	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	322	5	0	3	4.7	c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	CHEMBL2037522	75321	0	None	-6	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	322	5	0	3	4.7	c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	162661940	181855	0	None	12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4778946	181855	0	None	12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	118728523	117692	0	None	-5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401486	117692	0	None	-5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	42625269	186784	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	292	3	0	2	2.6	O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL489256	186784	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	292	3	0	2	2.6	O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1	10.1021/jm8014553
	44439388	91744	0	None	7	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	3	1	3	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL241082	91744	0	None	7	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	3	1	3	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	71450550	83778	0	None	-7	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83778	0	None	-7	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	1355	1998	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	142	1998	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	CHEMBL478	1998	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	DB12110	1998	88	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	57401516	68370	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	7	1	5	3.0	CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL1916746	68370	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	7	1	5	3.0	CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	156009734	177142	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	393	5	2	4	3.7	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4634426	177142	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	393	5	2	4	3.7	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	9821832	126430	1	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL365201	126430	1	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	162671253	183734	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4792933	183734	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4803811	183734	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	168286403	191720	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5197377	191720	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	43229249	140792	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140792	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	57402951	70439	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	6	0	5	5.1	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946258	70439	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	6	0	5	5.1	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	11261423	142374	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	445	8	2	4	4.4	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL388970	142374	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	445	8	2	4	4.4	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	118728507	117678	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	5	3.7	Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401470	117678	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	5	3.7	Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	43229249	140792	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140792	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	44393074	64247	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL180946	64247	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	137644790	158044	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4086211	158044	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	162664377	182174	0	None	75	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	533	9	1	6	6.3	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4782879	182174	0	None	75	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	533	9	1	6	6.3	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	156012551	177313	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	470	8	0	5	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4637294	177313	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	470	8	0	5	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	138691321	174495	0	None	18	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4555349	174495	0	None	18	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12	10.1016/j.ejmech.2019.03.017
	127039754	136657	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1039/C5MD00166H
	CHEMBL3740302	136657	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1039/C5MD00166H
	164619290	185781	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	463	7	0	5	4.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4866981	185781	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	463	7	0	5	4.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2021.128028
	57391624	71540	0	None	3	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949972	71540	0	None	3	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963102	71540	0	None	3	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
	11404955	56996	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	336	3	0	2	4.8	CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644488	56996	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	336	3	0	2	4.8	CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	44439391	145094	0	None	52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	3	2	4	3.3	COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2007.01.093
	CHEMBL391190	145094	0	None	52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	3	2	4	3.3	COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2007.01.093
	118709752	113515	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	362	8	0	2	4.6	O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321793	113515	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	362	8	0	2	4.6	O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	11463465	66848	0	None	-7	2	Rat	7.4	pKi	=	7.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL186334	66848	0	None	-7	2	Rat	7.4	pKi	=	7.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	10807321	99141	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	343	1	2	3	4.5	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3	10.1021/jm0108505
	CHEMBL281273	99141	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	343	1	2	3	4.5	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3	10.1021/jm0108505
	118713587	114344	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	367	6	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331255	114344	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	367	6	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	134151729	153421	0	None	5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3979307	153421	0	None	5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	72550196	114048	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326979	114048	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2014.07.026
	155524374	170896	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4455118	170896	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2016.06.080
	11429236	125392	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	390	8	1	5	2.4	COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1	10.1021/jm049743b
	CHEMBL364557	125392	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	390	8	1	5	2.4	COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1	10.1021/jm049743b
	57395597	68380	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	410	7	1	4	3.6	COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1016/j.bmc.2011.09.044
	CHEMBL1917330	68380	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	410	7	1	4	3.6	COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1016/j.bmc.2011.09.044
	145964159	164305	0	None	-77	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	164305	0	None	-77	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44439410	147264	0	None	5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	280	4	1	2	3.5	CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1	10.1016/j.bmcl.2007.01.093
	CHEMBL392888	147264	0	None	5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	280	4	1	2	3.5	CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1	10.1016/j.bmcl.2007.01.093
	44439407	167391	0	None	-11	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	424	8	0	4	5.9	CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL429644	167391	0	None	-11	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	424	8	0	4	5.9	CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	71459604	83764	0	None	-6	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205811	83764	0	None	-6	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	145979626	166517	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	454	6	2	5	1.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4279397	166517	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	454	6	2	5	1.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	118736371	118917	0	None	-9	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	6	0	9	2.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423335	118917	0	None	-9	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	6	0	9	2.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	118724643	120576	0	None	-8	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361002	120576	0	None	-8	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3545933	120576	0	None	-8	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	122483213	138068	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764178	138068	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765841	138068	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	135367399	163811	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4206411	163811	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	118736370	118916	0	None	-50	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	7	0	9	2.3	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423334	118916	0	None	-50	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	7	0	9	2.3	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	122483213	138068	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764178	138068	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765841	138068	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	27620	140793	13	None	-158	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818994	140793	13	None	-158	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	11209976	123147	0	None	1	3	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	CHEMBL361287	123147	0	None	1	3	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	71455894	83773	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205827	83773	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	71455894	83773	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	CHEMBL2205827	83773	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	135398745	2893	112	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	47	2893	112	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	CHEMBL715	2893	112	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	DB00334	2893	112	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	162644116	183596	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4778021	183596	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4802344	183596	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	155552054	173987	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1	10.1016/j.bmcl.2019.06.029
	CHEMBL4542754	173987	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1	10.1016/j.bmcl.2019.06.029
	155534312	171893	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	445	8	1	4	5.8	O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4469984	171893	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	445	8	1	4	5.8	O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	135367399	163811	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4206411	163811	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	136116062	97652	0	None	-10	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL271253	97652	0	None	-10	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	44391586	166320	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	CHEMBL427326	166320	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	44395817	66769	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	441	6	0	5	3.8	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL185988	66769	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	441	6	0	5	3.8	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	44424670	85696	0	None	-14	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	446	6	1	8	1.0	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL228940	85696	0	None	-14	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	446	6	1	8	1.0	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	135367821	163868	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207073	163868	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	137636384	155927	0	None	-741	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	356	4	0	4	2.5	CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23	10.1021/acsmedchemlett.6b00482
	CHEMBL4061189	155927	0	None	-741	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	356	4	0	4	2.5	CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23	10.1021/acsmedchemlett.6b00482
	11166042	166345	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2019.111705
	CHEMBL427518	166345	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2019.111705
	44461069	205572	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	377	5	0	3	4.1	CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81488	205572	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	377	5	0	3	4.1	CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	122181338	121854	0	None	-2	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	466	6	1	4	4.0	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590090	121854	0	None	-2	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	466	6	1	4	4.0	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	137650705	157210	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4076408	157210	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	137645926	157541	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4080398	157541	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	57395599	68407	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917357	68407	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	156016366	177615	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	458	10	1	6	4.0	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	CHEMBL4641296	177615	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	458	10	1	6	4.0	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	134130247	154551	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3890153	154551	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3991291	154551	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	44374233	51498	2	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	CHEMBL158285	51498	2	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	118736373	118919	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	545	7	0	9	3.6	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423337	118919	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	545	7	0	9	3.6	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	135398737	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	38	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	722	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	CHEMBL42	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	DB00363	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	44437334	150474	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL395444	150474	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44266178	98338	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	403	4	0	3	3.1	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275258	98338	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	403	4	0	3	3.1	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	134130247	154551	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3890153	154551	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3991291	154551	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	72549986	113796	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	457	10	1	4	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3325464	113796	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	457	10	1	4	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	53316914	56998	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	364	4	0	2	5.6	CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644490	56998	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	364	4	0	2	5.6	CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	9927441	207371	0	None	-1096	9	Human	5.4	pKi	=	5.4	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
	CHEMBL93868	207371	0	None	-1096	9	Human	5.4	pKi	=	5.4	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
	17055181	162428	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	409	7	1	2	6.2	Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4166667	162428	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	409	7	1	2	6.2	Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.010
	155547436	173548	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2019.06.029
	CHEMBL4532741	173548	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2019.06.029
	168278783	190706	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5182578	190706	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	135367821	163868	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207073	163868	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	155521504	176571	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4451939	176571	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4597600	176571	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
	164618208	185361	0	None	-371	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	467	6	0	5	3.7	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4860626	185361	0	None	-371	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	467	6	0	5	3.7	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	3132842	162963	9	None	-10	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	411	9	1	4	5.4	CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	CHEMBL4175296	162963	9	None	-10	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	411	9	1	4	5.4	CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	155516282	170045	0	None	-20	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1	10.1016/j.bmcl.2019.06.029
	CHEMBL4443185	170045	0	None	-20	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1	10.1016/j.bmcl.2019.06.029
	CHEMBL5281673	194099	0	None	-47	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	643	12	0	8	5.8	O=C1CC2Cc3ccsc3C2=NN1CCCCCCCN1CCN(Cc2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2023.117256
	122181343	121859	0	None	-17	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	528	7	1	4	5.3	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590095	121859	0	None	-17	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	528	7	1	4	5.3	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	122483292	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	57392108	68404	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917354	68404	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	145971561	164485	0	None	7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	444	4	1	4	3.7	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4214709	164485	0	None	7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	444	4	1	4	3.7	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	122483292	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	56945046	112033	0	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	7	1	6	4.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289955	112033	0	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	7	1	6	4.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	122178706	121346	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581251	121346	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	42618264	181455	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	394	8	1	5	3.3	COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476464	181455	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	394	8	1	5	3.3	COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL5090557	215247	0	None	-54	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	162665588	182372	0	None	-85	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4785434	182372	0	None	-85	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	122483292	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	138086	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	10610641	98891	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9911433
	CHEMBL27940	98891	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9911433
	11466615	138026	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	CHEMBL376531	138026	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	135458428	155510	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	CHEMBL404248	155510	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	66801701	159305	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	471	8	2	3	5.3	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4099997	159305	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	471	8	2	3	5.3	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	155521010	170568	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	572	9	1	6	5.4	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4450652	170568	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	572	9	1	6	5.4	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	90644075	112052	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	8	1	7	3.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289973	112052	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	8	1	7	3.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	46206026	124580	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	CHEMBL3640611	124580	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	46206026	124580	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	CHEMBL3640611	124580	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	2927683	162178	9	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	8	1	2	6.0	CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4162688	162178	9	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	8	1	2	6.0	CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1	10.1016/j.ejmech.2018.04.010
	146025727	171661	0	None	-141	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171661	0	None	-141	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	155536152	172115	0	None	-29	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	368	4	1	7	2.1	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4473083	172115	0	None	-29	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	368	4	1	7	2.1	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	57396855	71445	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949969	71445	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1962400	71445	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
	118736375	118921	0	None	-14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	477	6	0	9	2.2	Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C	10.1016/j.ejmech.2015.04.046
	CHEMBL3423339	118921	0	None	-14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	477	6	0	9	2.2	Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C	10.1016/j.ejmech.2015.04.046
	71461050	82948	0	None	-123	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181189	82948	0	None	-123	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	10971846	50463	0	None	-1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	420	8	1	4	5.0	O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL157362	50463	0	None	-1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	420	8	1	4	5.0	O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O	10.1021/jm020994z
	139488518	169973	0	None	14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2cccc(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4442337	169973	0	None	14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2cccc(F)c12	10.1016/j.ejmech.2019.03.017
	135367936	164449	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4214171	164449	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	156017609	177877	0	None	-19	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	464	9	1	6	4.9	O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1	10.1016/j.bmc.2020.115459
	CHEMBL4644906	177877	0	None	-19	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	464	9	1	6	4.9	O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1	10.1016/j.bmc.2020.115459
	155519102	170331	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4447416	170331	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	155519102	170331	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4447416	170331	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	155519102	170331	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL4447416	170331	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	1220	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	31	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	7	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	CHEMBL56	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	1220	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	31	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	7	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	CHEMBL56	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	1220	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	31	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	7	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	CHEMBL56	187	55	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	145946527	167546	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
	CHEMBL4217761	167546	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
	CHEMBL4300609	167546	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
	134155651	151106	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	329	4	0	2	5.2	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3959382	151106	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	329	4	0	2	5.2	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	25107652	187388	0	None	-20	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	CHEMBL493709	187388	0	None	-20	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	142601325	185845	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185845	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367936	164449	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4214171	164449	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	137655411	158732	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4093971	158732	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	127026147	137714	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	417	8	2	5	3.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759161	137714	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	417	8	2	5	3.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1	10.1016/j.ejmech.2015.11.040
	156014041	177184	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4635363	177184	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2020.115459
	90656700	112657	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3259846	112657	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304188	112657	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	90656687	110957	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	402	8	1	5	2.7	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262417	110957	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	402	8	1	5	2.7	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	145	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	1832	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	CHEMBL7257	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	DB14010	140	49	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	49850570	56442	0	None	-251	9	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632220	56442	0	None	-251	9	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	44343212	9806	0	None	50	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL114012	9806	0	None	50	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	135398737	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	38	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	722	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	CHEMBL42	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	DB00363	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	9934284	90267	0	None	-100	10	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238520	90267	0	None	-100	10	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	44439165	145728	0	None	-15	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL391661	145728	0	None	-15	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	11475386	122606	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	410	7	1	4	3.6	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1021/jm049743b
	CHEMBL360382	122606	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	410	7	1	4	3.6	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1021/jm049743b
	156022135	178194	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649788	178194	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	4223	3961	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	6918314	3961	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	7427	3961	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	CHEMBL439849	3961	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	DB06684	3961	94	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	76332583	106388	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121439	106388	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139517	106388	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	71453157	81143	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	3	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158038	81143	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	3	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	162676059	183762	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4796573	183762	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804095	183762	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	142601325	185845	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185845	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	90654679	110073	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235751	110073	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	156017397	177673	0	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	420	7	1	4	5.0	CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4642034	177673	0	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	420	7	1	4	5.0	CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	16117151	60057	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642882	60057	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739102	60057	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	127026052	137528	0	None	-23	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754496	137528	0	None	-23	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	10715998	45198	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL152595	45198	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	10596321	207441	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL94261	207441	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	11281062	119631	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	401	6	0	4	4.0	COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL346906	119631	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	401	6	0	4	4.0	COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	147653864	171537	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4464697	171537	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11168182	3508	25	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	264	3508	25	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	CHEMBL1181770	3508	25	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	276	3487	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
	5312149	3487	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
	CHEMBL431298	3487	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
	276	3487	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
	5312149	3487	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
	CHEMBL431298	3487	50	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
	44393007	66263	0	None	120	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL184789	66263	0	None	120	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393229	66667	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185512	66667	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393004	122148	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL359725	122148	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	5	139	72	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	5202	139	72	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	CHEMBL39	139	72	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	DB08839	139	72	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	145965054	164265	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	472	7	2	4	3.8	CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21	10.1021/acs.jmedchem.7b01898
	CHEMBL4211987	164265	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	472	7	2	4	3.8	CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21	10.1021/acs.jmedchem.7b01898
	9956365	195495	0	None	34	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm030030n
	CHEMBL553794	195495	0	None	34	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm030030n
	76320705	103512	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	CHEMBL3085301	103512	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	4106	2485	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	5358812	2485	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	89	2485	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	CHEMBL93240	2485	22	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	127024951	137615	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758286	137615	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	127026131	137725	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759233	137725	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1	10.1016/j.ejmech.2015.11.040
	118626101	165700	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245997	165700	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626142	165796	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248491	165796	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	71453281	81413	0	None	6	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159485	81413	0	None	6	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	71451460	81416	0	None	9	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159488	81416	0	None	9	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	139488606	170733	1	None	147	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4452569	170733	1	None	147	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12	10.1016/j.ejmech.2019.03.017
	54758295	65970	0	None	13	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	378	7	1	4	3.7	CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836789	65970	0	None	13	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	378	7	1	4	3.7	CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	118706732	120501	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310713	120501	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545445	120501	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	44374233	51498	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL158285	51498	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmcl.2003.11.050
	44374233	51498	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	CHEMBL158285	51498	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	118706285	112861	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310113	112861	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	118706301	120512	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310122	120512	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545473	120512	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	66801455	112042	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	8	2.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3289964	112042	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	8	2.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	66801062	112091	0	None	-4	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290011	112091	0	None	-4	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	11282296	143290	0	None	-1	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	143290	0	None	-1	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	135458427	171529	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	CHEMBL446459	171529	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	118524962	177645	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4641654	177645	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	11694810	120513	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3310123	120513	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545474	120513	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	10707685	162929	0	None	6	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O	10.1021/jm9911433
	CHEMBL417473	162929	0	None	6	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O	10.1021/jm9911433
	11694810	120513	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120513	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120513	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	66801225	112090	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	CHEMBL3290010	112090	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	2389	3306	118	None	-8	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	5073	3306	118	None	-8	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	96	3306	118	None	-8	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	CHEMBL85	3306	118	None	-8	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	DB00734	3306	118	None	-8	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	44388858	61467	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL177064	61467	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2009.02.008
	11566558	159432	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	354	6	1	3	4.6	CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410128	159432	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	354	6	1	3	4.6	CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	109018769	175264	1	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	337	7	1	3	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	CHEMBL4572955	175264	1	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	337	7	1	3	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	56944191	112075	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	8	1	5	4.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289996	112075	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	8	1	5	4.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	46206347	124533	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640566	124533	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	46206347	124533	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640566	124533	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	22449331	106908	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	360	5	1	2	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL314830	106908	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	360	5	1	2	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	44266156	98375	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	382	5	0	3	3.8	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275451	98375	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	382	5	0	3	3.8	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(03)00077-5
	11662592	72315	0	None	-3	9	Human	8.4	pKi	=	8.4	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL198463	72315	0	None	-3	9	Human	8.4	pKi	=	8.4	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	76321735	106369	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3121424	106369	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3139441	106369	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
	76321735	106369	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121424	106369	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139441	106369	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	134156520	154091	0	None	8	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	1	5	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3985152	154091	0	None	8	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	1	5	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	156013673	177237	0	None	10	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4636148	177237	0	None	10	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	66800916	112040	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	518	8	1	7	4.8	Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289962	112040	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	518	8	1	7	4.8	Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	44388858	61467	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL177064	61467	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	44388858	61467	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2007.03.054
	CHEMBL177064	61467	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2007.03.054
	24854043	95872	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	CHEMBL259215	95872	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	10971401	102669	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	1	2	5.5	Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	CHEMBL304731	102669	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	1	2	5.5	Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	164609172	184383	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4845947	184383	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	162674129	183189	0	None	-10	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4795995	183189	0	None	-10	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	164609172	184383	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4845947	184383	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	44437331	90934	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239530	90934	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	135339817	181460	0	None	1	7	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4764679	181460	0	None	1	7	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	11687730	120559	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343668	120559	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545816	120559	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	127024950	137766	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	412	8	1	6	2.1	Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759558	137766	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	412	8	1	6	2.1	Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1	10.1016/j.ejmech.2015.11.040
	118731360	118170	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	544	9	0	4	5.5	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409043	118170	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	544	9	0	4	5.5	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	162668650	182649	0	None	-13	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4789085	182649	0	None	-13	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	57396419	71513	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949976	71513	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1962961	71513	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	82187974	112654	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262406	112654	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304139	112654	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	135398737	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	38	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	722	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	CHEMBL42	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	DB00363	955	93	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	11532105	65973	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	432	6	1	2	5.8	O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	CHEMBL1836792	65973	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	432	6	1	2	5.8	O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	54758391	65980	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL1836859	65980	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	23369416	182463	2	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL478680	182463	2	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	155512406	169617	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	449	7	1	5	5.6	O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4437211	169617	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	449	7	1	5	5.6	O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	11385992	84639	0	None	1	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222477	84639	0	None	1	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	2389	3306	118	None	-7	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	5073	3306	118	None	-7	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	96	3306	118	None	-7	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	CHEMBL85	3306	118	None	-7	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	DB00734	3306	118	None	-7	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	44324643	207213	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	311	4	2	5	3.1	COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL92856	207213	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	311	4	2	5	3.1	COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1	10.1016/s0960-894x(02)00925-3
	10596321	207441	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	CHEMBL94261	207441	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	156010130	177015	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	5.1	CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4632499	177015	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	5.1	CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	59752589	179802	0	None	-26	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4745055	179802	0	None	-26	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	44439398	91184	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	5	0	5	4.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL240022	91184	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	5	0	5	4.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2	10.1016/j.bmcl.2007.01.093
	9950396	145098	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	4	1	4	3.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL391192	145098	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	4	1	4	3.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	59752584	181471	0	None	-128	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4764808	181471	0	None	-128	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	155519045	170302	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	446	8	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4446978	170302	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	446	8	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	118464420	138220	0	None	-67	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	138220	0	None	-67	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	53361627	66599	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1812288	66599	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1852767	66599	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
	155545088	176633	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4528793	176633	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598089	176633	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	72550864	114052	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326983	114052	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2014.07.026
	71462066	81137	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	4.4	CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158032	81137	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	4.4	CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	1353	1898	93	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	3559	1898	93	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	86	1898	93	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	CHEMBL54	1898	93	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	DB00502	1898	93	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	145975713	163918	0	None	10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207633	163918	0	None	10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	71451344	81134	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	3	4.4	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158029	81134	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	3	4.4	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1	10.1016/j.ejmech.2012.07.043
	56851049	71474	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926734	71474	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962693	71474	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
	76328892	106387	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121429	106387	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139511	106387	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	57390337	68406	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917356	68406	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	71462178	81397	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	7	1	4	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159469	81397	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	7	1	4	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	71574298	86256	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	526	8	1	5	5.1	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312936	86256	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	526	8	1	5	5.1	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	145976158	163818	0	None	53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4206468	163818	0	None	53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	118706278	120497	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310109	120497	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545439	120497	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	118706292	120508	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310117	120508	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545469	120508	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	118709754	113518	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	340	6	0	2	4.3	O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321796	113518	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	340	6	0	2	4.3	O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	66801116	112067	0	None	81	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	8	2.9	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289988	112067	0	None	81	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	8	2.9	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	11785995	84323	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	CHEMBL221732	84323	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	44437327	90838	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239231	90838	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	118713590	114348	0	None	16	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331259	114348	0	None	16	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	162675477	183418	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	464	6	0	4	5.4	COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4798874	183418	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	464	6	0	4	5.4	COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	44424653	142065	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	456	8	0	10	1.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL388133	142065	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	456	8	0	10	1.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	46204730	124543	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	CHEMBL3640576	124543	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	46204730	124543	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	CHEMBL3640576	124543	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	130442572	171884	0	None	-87	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-87	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	19958507	99393	0	None	-81	5	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	320	4	1	3	3.4	CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL282829	99393	0	None	-81	5	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	320	4	1	3	3.4	CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	46233353	202322	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	259	4	0	2	3.1	CN(C)CCSc1ccccc1Br	10.1016/j.bmc.2010.01.035
	CHEMBL610515	202322	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	259	4	0	2	3.1	CN(C)CCSc1ccccc1Br	10.1016/j.bmc.2010.01.035
	136118617	76220	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058416	76220	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	10267394	100361	3	None	-181	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL28997	100361	3	None	-181	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	57399432	70436	0	None	-14	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946254	70436	0	None	-14	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	90469187	185984	0	None	-1380	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	406	3	1	6	3.1	Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1	10.1021/acs.jmedchem.1c00224
	CHEMBL4870374	185984	0	None	-1380	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	406	3	1	6	3.1	Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1	10.1021/acs.jmedchem.1c00224
	71462065	81135	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	424	7	1	3	4.7	O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158030	81135	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	424	7	1	3	4.7	O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	145976698	163921	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207656	163921	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	90654695	110054	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	422	6	1	5	2.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235732	110054	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	422	6	1	5	2.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	11048252	204159	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	7	2	3	4.3	NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	CHEMBL70764	204159	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	7	2	3	4.3	NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	168296329	192414	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	359	3	2	4	2.7	O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1	10.1016/j.ejmech.2022.114218
	CHEMBL5208347	192414	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	359	3	2	4	2.7	O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1	10.1016/j.ejmech.2022.114218
	164628177	188587	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4875079	188587	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL5029038	188587	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL5079536	214599	0	None	-60	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1c(S(=O)(=O)N[C@H]2C[C@H](C)N(CCCc3noc4cc(F)ccc34)C2)sc2ccc(Cl)cc12	10.1021/acs.jmedchem.1c00497
	56850658	71491	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926745	71491	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962804	71491	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	53377324	66617	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1812290	66617	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1852853	66617	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
	135458672	117907	10	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	3	2	3	4.1	Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403337	117907	10	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	3	2	3	4.1	Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1016/j.bmcl.2015.03.049
	45113400	14199	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
	CHEMBL1099284	14199	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
	CHEMBL1199172	14199	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
	138691329	170699	0	None	100	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(Cl)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4452121	170699	0	None	100	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(Cl)cc12	10.1016/j.ejmech.2019.03.017
	127040444	136756	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	402	8	1	4	3.6	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1039/C5MD00166H
	CHEMBL3741279	136756	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	402	8	1	4	3.6	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1039/C5MD00166H
	156018601	177870	0	None	9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	414	6	1	5	3.4	C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4644833	177870	0	None	9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	414	6	1	5	3.4	C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	118051679	170125	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	480	9	1	7	2.8	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4444280	170125	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	480	9	1	7	2.8	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	59395105	106313	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3092755	106313	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3139187	106313	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	25108474	193176	0	None	-38	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL523381	193176	0	None	-38	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	44437330	152165	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396844	152165	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	71602692	89660	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376461	89660	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	162651292	180198	0	None	-33	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4749824	180198	0	None	-33	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	162666019	182276	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	9	0	6	6.4	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4784089	182276	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	9	0	6	6.4	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1	10.1016/j.ejmech.2020.112395
	164628177	188587	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4875079	188587	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL5029038	188587	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	155551114	176646	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4541606	176646	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598210	176646	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	13091356	113511	0	None	-102	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321789	113511	0	None	-102	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	155529153	171377	0	None	-38	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	378	4	1	6	0.3	CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4462404	171377	0	None	-38	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	378	4	1	6	0.3	CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	135367855	164358	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4213067	164358	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	60165541	75317	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	364	6	0	4	5.1	O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037518	75317	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	364	6	0	4	5.1	O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	24768523	143655	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL390015	143655	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	71727069	102378	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401935	102378	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL3039672	102378	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
	135367855	164358	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4213067	164358	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	71462155	81339	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	6	1	3	4.9	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159316	81339	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	6	1	3	4.9	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1	10.1016/j.ejmech.2012.07.043
	118464427	138309	0	None	-15	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	138309	0	None	-15	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	168282819	191186	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	419	10	4	8	3.1	COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5189520	191186	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	419	10	4	8	3.1	COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	11142729	119707	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL347629	119707	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O	10.1021/jm020994z
	1613	2333	53	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	205	2333	53	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	3964	2333	53	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	CHEMBL831	2333	53	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	DB00408	2333	53	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	24944943	102483	0	None	-17	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	CHEMBL2431038	102483	0	None	-17	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	CHEMBL3040400	102483	0	None	-17	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	122181346	121862	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590098	121862	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	145977256	163525	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	391	4	1	3	3.5	O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4202947	163525	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	391	4	1	3	3.5	O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	118731350	118161	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	10	1	4	4.3	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409034	118161	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	10	1	4	4.3	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	71602692	89660	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376461	89660	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	23151712	120510	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310120	120510	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545471	120510	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	118736369	118915	0	None	-4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	541	8	1	10	3.1	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423333	118915	0	None	-4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	541	8	1	10	3.1	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	16754	85545	50	None	2	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL228082	85545	50	None	2	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	44437335	151633	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396396	151633	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	10593348	97266	0	None	4	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL26907	97266	0	None	4	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	11375902	166209	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	CHEMBL426723	166209	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	11121721	119726	0	None	-6	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	0	4	3.9	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	CHEMBL347837	119726	0	None	-6	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	0	4	3.9	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	11058564	102046	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	2	3	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL302093	102046	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	2	3	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	134146195	154567	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3941795	154567	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3991399	154567	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL5088232	215123	0	None	-28	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	72549988	114047	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	11	1	4	5.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326978	114047	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	11	1	4	5.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	72547876	114056	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2014.07.026
	CHEMBL3326987	114056	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2014.07.026
	155540755	172920	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	6	3.8	COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1	10.1016/j.ejmech.2019.111690
	CHEMBL4516999	172920	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	6	3.8	COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1	10.1016/j.ejmech.2019.111690
	46205701	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	CHEMBL3640601	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	46205701	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	CHEMBL3640601	124569	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	71602583	89663	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376469	89663	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	155522563	176632	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4453687	176632	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598088	176632	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	162674779	183755	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4798599	183755	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804025	183755	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	13069611	120585	0	None	-363	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3360995	120585	0	None	-363	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3546110	120585	0	None	-363	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	90656684	110949	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262409	110949	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	71602583	89663	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376469	89663	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	137646045	157765	0	None	-436	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	404	4	0	5	4.3	CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1	10.1021/acsmedchemlett.6b00482
	CHEMBL4083059	157765	0	None	-436	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	404	4	0	5	4.3	CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1	10.1021/acsmedchemlett.6b00482
	242	469	124	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	34	469	124	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	60795	469	124	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	CHEMBL1112	469	124	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	DB01238	469	124	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	134146185	148813	0	None	18	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3941102	148813	0	None	18	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	138691362	170927	0	None	48	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	225	2	1	2	3.4	CCn1cncc1-c1c[nH]c2ccc(C)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4455588	170927	0	None	48	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	225	2	1	2	3.4	CCn1cncc1-c1c[nH]c2ccc(C)cc12	10.1016/j.ejmech.2019.03.017
	127038034	136644	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	416	9	1	4	3.8	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1039/C5MD00166H
	CHEMBL3740209	136644	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	416	9	1	4	3.8	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1039/C5MD00166H
	134146195	154567	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3941795	154567	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3991399	154567	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	24854106	161037	1	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
	CHEMBL411663	161037	1	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
	162668734	182580	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4788259	182580	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	134133968	154499	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3899099	154499	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3990801	154499	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	132547275	142218	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1	10.1016/j.bmc.2016.12.039
	CHEMBL3884714	142218	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1	10.1016/j.bmc.2016.12.039
	44424664	85686	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL228881	85686	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	73349361	92519	0	None	-5	7	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL2432058	92519	0	None	-5	7	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	76332581	106386	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121426	106386	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139510	106386	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	53325850	56981	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl	10.1016/j.bmcl.2010.11.078
	CHEMBL1644271	56981	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl	10.1016/j.bmcl.2010.11.078
	5074	3307	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	97	3307	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	CHEMBL267777	3307	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	DB12693	3307	80	None	-69	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	145983059	165621	0	None	-6	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243932	165621	0	None	-6	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	90654846	112669	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233672	112669	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304317	112669	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	134133968	154499	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3899099	154499	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3990801	154499	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	164621388	185712	0	None	-7	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	CHEMBL4866058	185712	0	None	-7	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	53323115	56989	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644279	56989	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	44439390	147779	0	None	33	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	4	2	3	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL393275	147779	0	None	33	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	4	2	3	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	132547278	142223	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	10	0	6	4.3	CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884778	142223	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	10	0	6	4.3	CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1	10.1016/j.bmc.2016.12.039
	76284455	104984	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	491	11	1	5	4.3	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113600	104984	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	491	11	1	5	4.3	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	135398737	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	38	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	722	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	CHEMBL42	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	DB00363	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	135398737	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	38	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	722	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	CHEMBL42	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	DB00363	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	118713685	114363	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	9	0	5	4.4	O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331388	114363	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	9	0	5	4.4	O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	6603866	97400	17	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
	CHEMBL26998	97400	17	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
	CHEMBL541268	97400	17	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
	11058267	204384	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	391	6	1	5	3.0	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3	10.1021/jm0104264
	CHEMBL72008	204384	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	391	6	1	5	3.0	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3	10.1021/jm0104264
	71602740	89588	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2375370	89588	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	164621388	185712	0	None	-7	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	CHEMBL4866058	185712	0	None	-7	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	44324572	206747	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	319	2	2	3	4.1	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL90150	206747	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	319	2	2	3	4.1	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1	10.1016/s0960-894x(02)00925-3
	162670644	182955	0	None	17	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	417	9	0	5	5.2	COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4793310	182955	0	None	17	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	417	9	0	5	5.2	COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	156017025	177702	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	351	2	0	1	6.1	CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL4642336	177702	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	351	2	0	1	6.1	CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1	10.1016/j.bmc.2019.115262
	11221282	56984	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	333	4	1	4	3.8	O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644274	56984	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	333	4	1	4	3.8	O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	162664163	183699	3	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4782285	183699	3	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803403	183699	3	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	46204736	124549	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640581	124549	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	46204736	124549	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640581	124549	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	156013736	177239	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	404	6	1	4	4.2	C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4636165	177239	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	404	6	1	4	4.2	C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	44408995	75405	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	CHEMBL204174	75405	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	90654858	112673	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233678	112673	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304355	112673	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
	155539600	172835	0	None	-239	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	7	2.7	CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4515075	172835	0	None	-239	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	7	2.7	CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	155524228	170851	0	None	-141	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4454176	170851	0	None	-141	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	11761105	53611	0	None	-13	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	396	10	0	5	4.3	COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	CHEMBL160286	53611	0	None	-13	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	396	10	0	5	4.3	COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	71454998	81388	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	9	1	4	4.5	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159460	81388	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	9	1	4	4.5	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	71574206	86239	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	512	7	1	5	4.7	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312641	86239	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	512	7	1	5	4.7	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	90654852	112609	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233675	112609	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302762	112609	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	155561901	175732	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	259	3	1	3	3.2	CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4583507	175732	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	259	3	1	3	3.2	CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12	10.1016/j.ejmech.2019.03.017
	71602740	89588	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2375370	89588	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	23661734	90857	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	425	6	0	4	3.8	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	CHEMBL239259	90857	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	425	6	0	4	3.8	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	44439395	91781	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	296	2	3	2	3.4	Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241280	91781	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	296	2	3	2	3.4	Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	72550641	114061	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	477	9	1	4	5.2	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326992	114061	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	477	9	1	4	5.2	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	117209857	185114	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185114	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL5089348	215180	0	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.1c00497
	135367405	164172	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	118713591	114350	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331260	114350	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	9862256	207097	0	None	-301	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL92139	207097	0	None	-301	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	11122723	50976	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	423	9	1	7	4.1	COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1	10.1021/jm020994z
	CHEMBL157840	50976	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	423	9	1	7	4.1	COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1	10.1021/jm020994z
	163409061	192165	3	None	-13	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	456	8	1	6	3.2	O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5204274	192165	3	None	-13	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	456	8	1	6	3.2	O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	155536809	172174	0	None	3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4473710	172174	0	None	3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	128	149	11	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
	172267	149	11	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
	CHEMBL273273	149	11	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
	1220	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	31	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	7	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	CHEMBL56	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	71062646	149519	0	None	-776	13	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	CHEMBL3946661	149519	0	None	-776	13	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	122181337	121853	0	None	-21	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	462	7	1	5	3.4	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590089	121853	0	None	-21	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	462	7	1	5	3.4	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	127028471	138156	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3769606	138156	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	117209857	185114	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185114	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	57325521	71541	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949977	71541	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1963103	71541	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	24854106	161037	1	None	-2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	CHEMBL411663	161037	1	None	-2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	135367405	164172	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	42625445	186754	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL489028	186754	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	162662892	181890	0	None	20	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4779459	181890	0	None	20	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	135398737	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	38	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	722	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	CHEMBL42	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	DB00363	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	72548117	114059	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326990	114059	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1	10.1016/j.bmc.2014.07.026
	135398737	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	38	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	722	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	CHEMBL42	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	DB00363	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	CHEMBL5093250	215397	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(F)c1	10.1021/acs.jmedchem.1c00497
	46205368	124556	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	CHEMBL3640588	124556	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	46205368	124556	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	CHEMBL3640588	124556	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	162666903	183710	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4787550	183710	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803553	183710	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	2133793	21785	13	None	1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	476	5	2	5	6.2	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL1319488	21785	13	None	1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	476	5	2	5	6.2	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1	10.1016/j.bmcl.2015.03.049
	3649661	138194	7	None	-64	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	138194	7	None	-64	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	76518514	113510	0	None	-50	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321788	113510	0	None	-50	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	118736395	118923	0	None	-234	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	493	7	1	11	0.7	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423377	118923	0	None	-234	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	493	7	1	11	0.7	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	168287240	191713	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	7	4.4	Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5197266	191713	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	7	4.4	Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	155534301	171911	0	None	-11	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	415	8	0	5	4.0	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4470304	171911	0	None	-11	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	415	8	0	5	4.0	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2019.06.029
	90654678	110072	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	2	5	2.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235750	110072	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	2	5	2.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	44424652	85895	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	426	7	0	9	1.0	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229940	85895	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	426	7	0	9	1.0	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	90654699	110058	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235736	110058	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	52952309	62560	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	427	7	1	6	4.8	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	CHEMBL1782807	62560	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	427	7	1	6	4.8	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	13069602	120586	0	None	-478	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360996	120586	0	None	-478	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546112	120586	0	None	-478	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	76310811	106250	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121417	106250	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139021	106250	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	6603866	97400	17	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL26998	97400	17	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL541268	97400	17	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	135398737	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	38	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	722	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	CHEMBL42	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	DB00363	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	23369455	181451	2	None	1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	350	6	1	4	2.9	O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476462	181451	2	None	1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	350	6	1	4	2.9	O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	135398737	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	38	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	722	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	CHEMBL42	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	DB00363	955	93	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	11248332	84281	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL221513	84281	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	127036953	137490	0	None	-4	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754166	137490	0	None	-4	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	117209971	186461	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186461	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL5076846	214441	0	None	-75	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(F)cc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	9926401	140850	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140850	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140850	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	53377239	66360	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851772	66360	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
	CHEMBL3217162	66360	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
	155514217	169808	0	None	-17	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	461	8	0	5	3.9	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4439795	169808	0	None	-17	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	461	8	0	5	3.9	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	155551685	175108	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	495	8	0	5	4.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4569757	175108	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	495	8	0	5	4.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	164618482	185891	0	None	-13	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4868911	185891	0	None	-13	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2020.112529
	155552799	176281	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4545270	176281	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595236	176281	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	9878197	196155	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	250	4	4	3	1.0	CCOc1ccccc1CNC(=N)NC(=O)NC	10.1016/j.bmcl.2009.06.038
	CHEMBL561346	196155	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	250	4	4	3	1.0	CCOc1ccccc1CNC(=N)NC(=O)NC	10.1016/j.bmcl.2009.06.038
	127037921	137006	0	None	4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	9	0	6	3.7	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.bmc.2015.11.041
	CHEMBL3746493	137006	0	None	4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	9	0	6	3.7	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.bmc.2015.11.041
	155512944	169695	0	None	11	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	249	1	1	2	3.4	Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4438349	169695	0	None	11	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	249	1	1	2	3.4	Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	127038035	136692	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1039/C5MD00166H
	CHEMBL3740691	136692	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1039/C5MD00166H
	117209971	186461	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186461	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	9926401	140850	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140850	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140850	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	24768517	92799	0	None	2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243742	92799	0	None	2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	57397588	71450	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926747	71450	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962460	71450	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	90654691	110050	0	None	-21	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	432	10	1	5	3.0	CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235728	110050	0	None	-21	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	432	10	1	5	3.0	CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	162673808	183750	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4795248	183750	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803963	183750	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	11421045	136916	0	None	1	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL374298	136916	0	None	1	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	134133633	154568	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3899822	154568	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991400	154568	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	44582678	181550	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476839	181550	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	44393088	64983	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182322	64983	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	44393170	65205	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182680	65205	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393171	65359	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182943	65359	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	10785714	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030030n
	CHEMBL13052	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030030n
	127042184	136957	0	None	6	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	468	8	0	4	4.7	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	CHEMBL3745815	136957	0	None	6	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	468	8	0	4	4.7	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	2865	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	59	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	60854	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	CHEMBL708	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	DB00246	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	71458625	81346	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	3.6	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159322	81346	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	3.6	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	71458626	81347	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159323	81347	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	118731356	118166	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	118166	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	138691364	171883	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4469847	171883	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1016/j.ejmech.2019.03.017
	138691364	171883	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	CHEMBL4469847	171883	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	145982165	166580	0	None	51	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1	10.1039/C8MD00168E
	CHEMBL4280511	166580	0	None	51	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1	10.1039/C8MD00168E
	137651887	157275	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	7	2	3	4.6	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4077040	157275	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	7	2	3	4.6	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	9845006	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL12702	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	11646336	65966	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm200547z
	CHEMBL1836785	65966	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm200547z
	44372581	119793	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	420	6	1	2	5.8	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL348410	119793	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	420	6	1	2	5.8	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	9845006	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12702	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	10785714	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL13052	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	9845006	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	CHEMBL12702	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	10785714	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	CHEMBL13052	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	162659494	181330	0	None	-15	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4763085	181330	0	None	-15	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	162674158	182979	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4793608	182979	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	107	141	121	None	-3	31	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
	1833	141	121	None	-3	31	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
	CHEMBL8165	141	121	None	-3	31	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
	2865	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	59	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	60854	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	CHEMBL708	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	DB00246	4112	73	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	11536843	115097	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	115097	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	54758293	65967	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.3	CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836786	65967	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.3	CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	56944186	112063	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	8	1	7	4.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289984	112063	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	8	1	7	4.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	56944190	112073	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	499	8	1	5	5.2	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289994	112073	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	499	8	1	5	5.2	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	25107578	193032	0	None	4	3	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	CHEMBL522343	193032	0	None	4	3	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	24854370	157046	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL407412	157046	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	9845006	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL12702	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	9845006	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	CHEMBL12702	18207	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	118713680	114358	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	411	8	0	6	4.1	COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331383	114358	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	411	8	0	6	4.1	COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	92042876	151312	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	10402615	202494	0	None	-20	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL611472	202494	0	None	-20	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	92042876	151312	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	151312	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	10785714	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL13052	20196	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	92042876	151312	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	71457985	78508	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2	10.1016/j.bmcl.2004.11.013
	CHEMBL2112053	78508	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2	10.1016/j.bmcl.2004.11.013
	11153905	65576	0	None	-2	2	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1021/jm0498102
	CHEMBL183329	65576	0	None	-2	2	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1021/jm0498102
	156013466	177485	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4639638	177485	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	156013520	177487	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4639661	177487	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	66801140	111635	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3286432	111635	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	24854039	95738	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL258537	95738	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	11603891	96886	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL265927	96886	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	11617668	64666	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL181874	64666	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	11603891	96886	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL265927	96886	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	11617668	64666	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2007.03.054
	CHEMBL181874	64666	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2007.03.054
	46205370	124558	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	CHEMBL3640590	124558	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	46205370	124558	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	CHEMBL3640590	124558	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	162650362	179989	0	None	-27	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4747225	179989	0	None	-27	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	135398737	955	93	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	38	955	93	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	722	955	93	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	CHEMBL42	955	93	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	DB00363	955	93	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	10706553	97668	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL27132	97668	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	101747513	173298	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	277	4	0	5	3.2	CN(C)CCSc1nc2ccsc2n2cccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4526441	173298	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	277	4	0	5	3.2	CN(C)CCSc1nc2ccsc2n2cccc12	10.1016/j.ejmech.2019.111690
	154926523	190267	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	425	9	1	4	4.2	CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	CHEMBL5175774	190267	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	425	9	1	4	4.2	CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	11976	917	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	667467	917	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	CHEMBL908	917	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	DB01239	917	59	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	23661594	90596	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL238808	90596	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	25107718	187514	0	None	18	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1021/jm800615e
	CHEMBL494458	187514	0	None	18	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1021/jm800615e
	9887186	204274	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	399	5	2	2	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3	10.1021/jm0104264
	CHEMBL71383	204274	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	399	5	2	2	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3	10.1021/jm0104264
	10948963	48985	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	CHEMBL156089	48985	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	135398737	955	93	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	38	955	93	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	722	955	93	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	CHEMBL42	955	93	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	DB00363	955	93	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	156011291	177352	0	None	-9	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4637900	177352	0	None	-9	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	118713679	114357	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	6	3.6	COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331382	114357	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	6	3.6	COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	56944189	112066	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	454	8	1	8	2.4	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3289987	112066	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	454	8	1	8	2.4	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	24854272	96170	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	CHEMBL260761	96170	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	46204081	124524	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	CHEMBL3640558	124524	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	46204081	124524	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	CHEMBL3640558	124524	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	90654704	110063	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	413	8	1	6	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235741	110063	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	413	8	1	6	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	127026141	137639	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	8	1	6	3.4	Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758488	137639	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	8	1	6	3.4	Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1	10.1016/j.ejmech.2015.11.040
	155562997	175213	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.ejmech.2019.111736
	CHEMBL4571862	175213	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.ejmech.2019.111736
	145946840	167562	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4176588	167562	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4300745	167562	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	57394663	71526	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949973	71526	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963031	71526	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
	118706294	120509	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310118	120509	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545470	120509	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	122178708	121348	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581253	121348	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	53248365	62056	0	None	-52	7	Human	7.3	pKi	=	7.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	554	6	1	5	2.9	O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I	10.1021/jm1009956
	CHEMBL1774995	62056	0	None	-52	7	Human	7.3	pKi	=	7.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	554	6	1	5	2.9	O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I	10.1021/jm1009956
	277	1289	62	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	2913	1289	62	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	765	1289	62	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL516	1289	62	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	DB00434	1289	62	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	8431	1472	9	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	9843179	1472	9	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	CHEMBL69257	1472	9	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	277	1289	62	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	2913	1289	62	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	765	1289	62	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	CHEMBL516	1289	62	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	DB00434	1289	62	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	155549018	174218	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4548926	174218	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2016.06.080
	191	402	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	201	402	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	2170	402	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	CHEMBL1113	402	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	DB00543	402	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	44439399	147367	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	5	0	5	4.8	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL392970	147367	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	5	0	5	4.8	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	59752538	181128	0	None	-251	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4760784	181128	0	None	-251	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	156308	169259	5	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	354	2	0	4	3.2	COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmcl.2007.01.093
	CHEMBL441356	169259	5	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	354	2	0	4	3.2	COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmcl.2007.01.093
	10287730	3510	40	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	77	3510	40	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	CHEMBL425190	3510	40	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	11304596	56366	0	None	-3162	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631542	56366	0	None	-3162	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	134133633	154568	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3899822	154568	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991400	154568	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	1220	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	31	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	7	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	CHEMBL56	187	55	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	135367400	163947	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207901	163947	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	127052778	140820	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819403	140820	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	5242341	198133	2	None	-30	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	0	5	3.7	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL574827	198133	2	None	-30	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	0	5	3.7	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	135367400	163947	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207901	163947	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	46204733	124546	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	CHEMBL3640579	124546	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	46204733	124546	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	CHEMBL3640579	124546	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	155552213	176634	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4546775	176634	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598090	176634	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	164615243	185186	0	None	-21	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4857676	185186	0	None	-21	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	90654671	110065	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	8	1	5	3.1	CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235743	110065	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	8	1	5	3.1	CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	145984511	165600	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243497	165600	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	156016856	177652	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	295	2	0	1	4.4	Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2	10.1016/j.bmc.2019.115262
	CHEMBL4641769	177652	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	295	2	0	1	4.4	Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2	10.1016/j.bmc.2019.115262
	155513438	169705	0	None	-10	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	346	6	3	3	4.8	Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4438434	169705	0	None	-10	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	346	6	3	3	4.8	Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	56945042	158017	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4085802	158017	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	44424659	85741	0	None	-4	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229231	85741	0	None	-4	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL2448068	85741	0	None	-4	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	127052467	140826	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819494	140826	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	11747350	107305	0	None	-25	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
	CHEMBL317535	107305	0	None	-25	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
	118736366	118912	0	None	-257	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	6	1	10	1.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423330	118912	0	None	-257	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	6	1	10	1.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	25263297	184313	0	None	-645	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	CHEMBL484345	184313	0	None	-645	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	135464118	93031	0	None	-14	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442272	93031	0	None	-14	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	122483262	138064	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763883	138064	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765837	138064	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	60167452	75325	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037526	75325	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	6604117	187823	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL2062340	187823	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL49623	187823	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	122483262	138064	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763883	138064	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765837	138064	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	155562918	175159	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4570584	175159	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	162674513	183754	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4798559	183754	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804009	183754	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	122181340	121856	0	None	-14	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590092	121856	0	None	-14	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	162661627	183685	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4778919	183685	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803268	183685	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	118464425	138284	0	None	-13	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	138284	0	None	-13	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	44582677	181549	0	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476838	181549	0	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	60167452	75325	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037526	75325	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	60167452	75325	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037526	75325	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	46205372	124560	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	CHEMBL3640592	124560	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	10904975	164843	0	None	17	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	379	7	1	6	3.7	O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL422008	164843	0	None	17	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	379	7	1	6	3.7	O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	11327137	66710	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	403	8	1	5	2.5	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	CHEMBL185762	66710	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	403	8	1	5	2.5	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	46205372	124560	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	CHEMBL3640592	124560	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	CHEMBL5094680	215487	0	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	137631892	156361	0	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4066426	156361	0	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	137660741	159345	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4100470	159345	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	145985718	165501	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241081	165501	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626169	165551	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242268	165551	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	134147124	149956	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3950020	149956	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	145975106	163637	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	1	4	5.2	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	CHEMBL4204459	163637	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	1	4	5.2	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	145972875	164704	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4217506	164704	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	109026949	174582	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	392	6	0	4	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4557369	174582	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	392	6	0	4	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	54758296	65974	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	426	7	1	2	6.0	CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	CHEMBL1836793	65974	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	426	7	1	2	6.0	CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	127052467	140826	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819494	140826	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	122178702	121342	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581247	121342	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL5094680	215487	0	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	135367820	164797	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	11257340	122011	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	374	7	1	4	2.7	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2	10.1021/jm049743b
	CHEMBL359538	122011	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	374	7	1	4	2.7	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2	10.1021/jm049743b
	66801624	156478	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	6	2	3	5.4	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	CHEMBL4067700	156478	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	6	2	3	5.4	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	11568826	132773	0	None	-446	8	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL370110	132773	0	None	-446	8	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	156010209	177130	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4634062	177130	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	164620748	186221	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL4873623	186221	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	164620748	186221	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4873623	186221	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	16026344	22218	4	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	373	2	0	3	5.0	O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21	10.1016/j.bmcl.2015.03.049
	CHEMBL1323386	22218	4	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	373	2	0	3	5.0	O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21	10.1016/j.bmcl.2015.03.049
	155555506	174358	0	None	-8	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	330	6	1	2	5.1	CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1	10.1016/j.ejmech.2019.111857
	CHEMBL4552041	174358	0	None	-8	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	330	6	1	2	5.1	CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1	10.1016/j.ejmech.2019.111857
	46205041	124550	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	CHEMBL3640582	124550	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	46205041	124550	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	CHEMBL3640582	124550	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	164624803	186188	0	None	-28	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4873127	186188	0	None	-28	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	145978472	163579	0	None	14	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	438	4	1	4	2.7	O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1	10.1016/j.bmcl.2018.06.019
	CHEMBL4203581	163579	0	None	14	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	438	4	1	4	2.7	O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1	10.1016/j.bmcl.2018.06.019
	127027388	137626	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	8	1	5	3.6	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758378	137626	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	8	1	5	3.6	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1	10.1016/j.ejmech.2015.11.040
	127042841	136980	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	488	9	0	4	5.1	CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3746083	136980	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	488	9	0	4	5.1	CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	76284193	146572	0	None	19	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	444	10	1	5	3.6	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3923145	146572	0	None	19	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	444	10	1	5	3.6	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1016/j.ejmech.2016.05.005
	156012741	177263	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.4	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4636435	177263	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.4	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2020.115459
	155538367	172357	0	None	30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4476372	172357	0	None	30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	155541872	176661	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4519312	176661	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598357	176661	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	44408820	140880	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.3	O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL382163	140880	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.3	O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	24854370	157046	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL407412	157046	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	135367820	164797	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134130462	142288	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	7	0	5	3.7	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3885389	142288	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	7	0	5	3.7	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	44439400	91185	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	7	0	4	5.2	CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL240023	91185	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	7	0	4	5.2	CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	138691317	171513	0	None	5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	211	2	1	2	3.1	CCn1cncc1-c1c[nH]c2ccccc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4464377	171513	0	None	5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	211	2	1	2	3.1	CCn1cncc1-c1c[nH]c2ccccc12	10.1016/j.ejmech.2019.03.017
	155548677	173704	0	None	-257	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	7	3	4	4.8	COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4536315	173704	0	None	-257	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	7	3	4	4.8	COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	46204419	124534	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	CHEMBL3640567	124534	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	46204419	124534	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	CHEMBL3640567	124534	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	53323535	56995	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644487	56995	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	145975778	163557	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203312	163557	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	136118659	76226	0	None	-3	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058427	76226	0	None	-3	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	71602523	89662	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376463	89662	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	71602523	89662	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376463	89662	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	52952419	62551	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	358	5	0	5	3.3	O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782794	62551	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	358	5	0	5	3.3	O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	10662302	99320	0	None	-2	5	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL282375	99320	0	None	-2	5	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	24768519	92834	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243953	92834	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	44393053	65235	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	349	8	2	6	3.8	Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1	10.1016/j.bmcl.2004.06.008
	CHEMBL182805	65235	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	349	8	2	6	3.8	Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1	10.1016/j.bmcl.2004.06.008
	11372669	67388	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	388	8	0	4	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1	10.1021/jm049743b
	CHEMBL188876	67388	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	388	8	0	4	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1	10.1021/jm049743b
	76336184	106246	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121434	106246	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139017	106246	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	127026443	137813	0	None	85	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	4	3.9	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759925	137813	0	None	85	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	4	3.9	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	134139826	146507	0	None	12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3922670	146507	0	None	12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	156012823	177386	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	548	11	0	6	6.2	Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1	10.1016/j.bmc.2020.115459
	CHEMBL4638388	177386	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	548	11	0	6	6.2	Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1	10.1016/j.bmc.2020.115459
	21048822	140194	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	377	6	0	3	4.3	CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL380511	140194	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	377	6	0	3	4.3	CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	23661667	85735	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL1203946	85735	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229181	85735	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	66801115	112037	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	506	7	1	7	4.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289959	112037	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	506	7	1	7	4.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	122178711	121351	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581256	121351	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	25108475	187461	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL494119	187461	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	23661667	85735	0	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL1203946	85735	0	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL229181	85735	0	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
	10333670	94757	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL253319	94757	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	155565209	175567	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4579764	175567	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	155535154	172018	0	None	-10	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	556	9	1	7	5.2	COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1	10.1016/j.ejmech.2019.07.027
	CHEMBL4471755	172018	0	None	-10	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	556	9	1	7	5.2	COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1	10.1016/j.ejmech.2019.07.027
	145966154	164163	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	402	8	1	4	3.6	CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4210708	164163	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	402	8	1	4	3.6	CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	122483244	138070	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764136	138070	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765843	138070	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	44448054	94756	0	None	1	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1021/jm060959i
	CHEMBL253318	94756	0	None	1	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1021/jm060959i
	132503215	157726	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4082456	157726	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	57392107	68395	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917345	68395	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	145966418	164217	0	None	6	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4211253	164217	0	None	6	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	46205703	124571	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	CHEMBL3640603	124571	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	46205703	124571	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	CHEMBL3640603	124571	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	44408987	76530	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.9	CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206269	76530	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.9	CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	122483244	138070	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764136	138070	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765843	138070	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	5280953	97333	109	None	-6	8	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
	CHEMBL269538	97333	109	None	-6	8	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
	3564	118122	86	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2c3c([nH]c2c1)C(C)=NCC3	10.1021/acs.jmedchem.0c01887
	CHEMBL1494278	118122	86	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2c3c([nH]c2c1)C(C)=NCC3	10.1021/acs.jmedchem.0c01887
	CHEMBL340807	118122	86	None	-3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assayDisplacement of [3H]-citalopram from human 5-HT7 expressed in human HEK cells assessed as inhibition constant by FLIPR assay	ChEMBL	214	1	1	2	2.5	COc1ccc2c3c([nH]c2c1)C(C)=NCC3	10.1021/acs.jmedchem.0c01887
	90654675	110069	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	1	5	2.4	COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235747	110069	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	1	5	2.4	COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	46233381	201901	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	257	5	0	2	4.0	CN(C)CCSc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	CHEMBL607584	201901	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	257	5	0	2	4.0	CN(C)CCSc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	137645501	157621	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4081383	157621	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	127028798	138159	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769612	138159	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	127039593	136965	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	460	10	0	6	3.5	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3745882	136965	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	460	10	0	6	3.5	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	127042539	137059	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747148	137059	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	71574306	86237	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312639	86237	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	57325520	71509	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949963	71509	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1962945	71509	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	135	2515	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	1796	2515	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	4184	2515	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	CHEMBL6437	2515	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	DB06148	2515	43	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	155532137	171670	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.3	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4466596	171670	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.3	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	168283140	191075	0	None	-34	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5187742	191075	0	None	-34	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	10365873	67221	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	438	8	0	4	4.3	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm049743b
	CHEMBL188036	67221	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	438	8	0	4	4.3	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm049743b
	127052778	140820	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819403	140820	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	18377342	107086	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL316039	107086	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	145947762	167674	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4170484	167674	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302327	167674	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	42618256	181571	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL477065	181571	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	90654692	110051	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	6	1	5	2.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235729	110051	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	6	1	5	2.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	155547197	173571	0	None	-758	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4533305	173571	0	None	-758	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	145983468	165412	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238897	165412	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	90656677	112576	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262402	112576	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302044	112576	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	44424666	144346	0	None	5	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	425	8	0	8	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL390580	144346	0	None	5	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	425	8	0	8	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	118706299	120511	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310121	120511	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545472	120511	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	66801259	112068	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	8	3.3	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289989	112068	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	8	3.3	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	44401194	71266	0	None	-7	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL195706	71266	0	None	-7	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	118713594	114353	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	365	7	0	5	3.6	O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331263	114353	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	365	7	0	5	3.6	O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	44340882	9482	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	392	5	2	5	2.5	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL112150	9482	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	392	5	2	5	2.5	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	155554837	174612	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4558031	174612	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	168283630	191265	0	None	-57	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	458	6	0	6	3.6	N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.ejmech.2022.114193
	CHEMBL5190788	191265	0	None	-57	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	458	6	0	6	3.6	N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.ejmech.2022.114193
	49783209	17577	0	None	-10000	27	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17577	0	None	-10000	27	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	164618100	185336	0	None	-128	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL4860275	185336	0	None	-128	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	44437331	90934	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239530	90934	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44424663	138119	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	397	6	0	8	1.3	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL376773	138119	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	397	6	0	8	1.3	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL4518342	213949	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7	ChEMBL		None	None	None		CC(C)CC(=O)N1CCc2nc(-c3ccc(Br)cc3)nc(N(C)Cc3ccccc3)c2C1	10.6019/CHEMBL5212743
	90654677	110071	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	484	6	1	5	3.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235749	110071	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	484	6	1	5	3.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	9978683	18642	0	None	-363	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277104	18642	0	None	-363	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	127041563	136979	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	CHEMBL3746079	136979	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	127041564	137026	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	7	0	6	2.9	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	CHEMBL3746771	137026	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	7	0	6	2.9	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	71453279	81403	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159475	81403	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	145976292	163608	0	None	31	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	9	1	4	4.7	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	CHEMBL4203908	163608	0	None	31	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	9	1	4	4.7	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	155554837	174612	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4558031	174612	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	155562543	175148	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4570411	175148	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	122178701	121341	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581246	121341	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	155562543	175148	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4570411	175148	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	25263302	191960	0	None	-4466	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	CHEMBL520129	191960	0	None	-4466	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	56673112	66337	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851637	66337	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216275	66337	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
	44408988	166043	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	336	6	0	4	2.4	CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	CHEMBL425767	166043	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	336	6	0	4	2.4	CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	155538814	173239	0	None	-38	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4524981	173239	0	None	-38	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2019.06.022
	168283609	191213	0	None	-2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	418	10	5	8	3.1	COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5190020	191213	0	None	-2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	418	10	5	8	3.1	COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	155544139	173329	0	None	-30	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl	10.1016/j.ejmech.2019.06.022
	CHEMBL4527124	173329	0	None	-30	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl	10.1016/j.ejmech.2019.06.022
	122483228	137987	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764661	137987	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	155556527	174486	0	None	-7	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	247	2	1	2	3.3	CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4555115	174486	0	None	-7	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	247	2	1	2	3.3	CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12	10.1016/j.ejmech.2019.03.017
	72198014	89789	0	None	-18	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	484	7	2	4	4.8	COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377443	89789	0	None	-18	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	484	7	2	4	4.8	COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	71458624	81338	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	3	4.5	Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159315	81338	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	3	4.5	Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	145966199	164243	0	None	22	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	2	5	3.7	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	CHEMBL4211665	164243	0	None	22	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	2	5	3.7	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	44582675	189677	0	None	1	15	Human	7.2	pKi	=	7.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL515472	189677	0	None	1	15	Human	7.2	pKi	=	7.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	46206346	124583	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	CHEMBL3640614	124583	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	46206346	124583	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	CHEMBL3640614	124583	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	10992240	53518	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	CHEMBL160194	53518	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	25130235	187563	1	None	-169	11	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	187563	1	None	-169	11	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	122483228	137987	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764661	137987	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	164615340	185405	0	None	-25	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4861431	185405	0	None	-25	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	155530351	176260	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4464370	176260	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595115	176260	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	44393133	64818	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182070	64818	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	9945703	66651	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185437	66651	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	2865	4112	73	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	59	4112	73	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	60854	4112	73	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	CHEMBL708	4112	73	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	DB00246	4112	73	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	44456033	155543	3	None	-4	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL404372	155543	3	None	-4	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	10202089	195723	0	None	87	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	417	4	3	4	3.4	COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL557330	195723	0	None	87	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	417	4	3	4	3.4	COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	145985585	165865	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4249640	165865	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71451459	81415	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159487	81415	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	145946947	167578	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4176950	167578	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4300976	167578	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145947404	167646	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4163778	167646	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301967	167646	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	138691314	164612	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4216263	164612	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	138691314	164612	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1039/C8MD00313K
	CHEMBL4216263	164612	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1039/C8MD00313K
	155537034	172261	0	None	36	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	240	2	2	3	1.7	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	CHEMBL4474827	172261	0	None	36	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	240	2	2	3	1.7	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	127039755	136628	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	470	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1039/C5MD00166H
	CHEMBL3740055	136628	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	470	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1039/C5MD00166H
	11151899	2124	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
	8432	2124	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
	CHEMBL4205783	2124	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
	11323169	179943	0	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4746737	179943	0	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	56944953	159630	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4103725	159630	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	155563911	175392	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	534	10	1	7	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4575904	175392	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	534	10	1	7	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	138691314	164612	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1021/acs.jmedchem.7b01898
	CHEMBL4216263	164612	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1021/acs.jmedchem.7b01898
	11153067	76723	1	None	34	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	375	6	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206748	76723	1	None	34	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	375	6	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1	10.1016/j.bmcl.2005.11.067
	5	139	72	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	72	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	72	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	72	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	25107516	187161	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL492282	187161	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	25256850	189709	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	364	7	1	4	3.3	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL515780	189709	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	364	7	1	4	3.3	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	10917174	102155	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	439	7	1	3	5.6	C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL302766	102155	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	439	7	1	3	5.6	C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	11397799	84704	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222864	84704	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	9881600	55167	4	None	8	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL161765	55167	4	None	8	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	24963856	88316	0	None	363	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	253	4	0	1	4.1	Cc1cccc(C)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL234881	88316	0	None	363	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	253	4	0	1	4.1	Cc1cccc(C)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	44401164	69787	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193639	69787	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	135398737	955	93	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	38	955	93	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	722	955	93	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	CHEMBL42	955	93	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	DB00363	955	93	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	153287553	171080	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4457754	171080	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	66800991	112041	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	8	2.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3289963	112041	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	8	2.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	66800910	112080	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	437	8	1	6	4.0	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3290000	112080	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	437	8	1	6	4.0	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	1621	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	17	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	5761	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	CHEMBL263881	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	DB04829	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	11307899	78839	0	None	-100	7	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
	CHEMBL2112882	78839	0	None	-100	7	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
	44341114	113363	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL331803	113363	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1	10.1016/s0960-894x(02)00690-x
	133	2479	52	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	1723	2479	52	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	28693	2479	52	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	CHEMBL19215	2479	52	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	DB13520	2479	52	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	CHEMBL5081379	214723	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134133064	144710	0	None	4	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	CHEMBL3908870	144710	0	None	4	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	153287553	171080	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4457754	171080	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	133	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	1723	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	28693	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	CHEMBL19215	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	DB13520	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	133	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	1723	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	28693	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	CHEMBL19215	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	DB13520	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	133	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	1723	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	28693	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	CHEMBL19215	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	DB13520	2479	52	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	22857296	29119	0	None	9	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL13816	29119	0	None	9	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	11465316	65232	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1016/j.bmcl.2004.11.013
	CHEMBL182792	65232	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1016/j.bmcl.2004.11.013
	11465316	65232	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	CHEMBL182792	65232	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	9799318	106508	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL314055	106508	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	44341126	9437	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL111922	9437	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	44340883	9634	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL112876	9634	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	10884717	204249	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	441	5	1	4	5.1	CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71225	204249	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	441	5	1	4	5.1	CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	162657983	181024	0	None	-26	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4759492	181024	0	None	-26	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	9799318	106508	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1021/jm0498102
	CHEMBL314055	106508	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1021/jm0498102
	134157171	153914	0	None	24	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	1	6	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3983496	153914	0	None	24	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	1	6	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	142601329	186493	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186493	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	156010865	177107	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633786	177107	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	11151899	2124	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
	8432	2124	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
	CHEMBL4205783	2124	13	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
	11186523	127485	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL366164	127485	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	24854269	157910	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	497	10	0	4	5.9	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21	10.1021/jm070279v
	CHEMBL408451	157910	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	497	10	0	4	5.9	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21	10.1021/jm070279v
	1621	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	17	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	5761	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	CHEMBL263881	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	DB04829	2413	17	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	90656712	110943	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	399	5	2	3	5.0	CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262395	110943	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	399	5	2	3	5.0	CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	11432177	85093	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	CHEMBL224820	85093	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	44401164	69787	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193639	69787	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	142601329	186493	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186493	5	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	11432177	85093	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	85093	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	54758298	65978	0	None	-4	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	CHEMBL1836857	65978	0	None	-4	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	56943599	112059	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289980	112059	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL5081379	214723	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	118728525	117694	0	None	-6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	420	9	0	6	3.8	CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401488	117694	0	None	-6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	420	9	0	6	3.8	CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	10562462	99664	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1021/jm9911433
	CHEMBL284586	99664	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1021/jm9911433
	76318011	105480	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	425	5	0	4	5.6	COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121422	105480	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	425	5	0	4	5.6	COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	60196079	81777	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL2164329	81777	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	24854039	95738	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL258537	95738	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	56943891	112024	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289946	112024	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	10562462	99664	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1016/s0960-894x(00)00655-7
	CHEMBL284586	99664	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1016/s0960-894x(00)00655-7
	44266160	207481	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	421	4	0	3	3.3	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9446	207481	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	421	4	0	3	3.3	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	162661903	181404	0	None	-19	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	CHEMBL4764006	181404	0	None	-19	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	24854103	96126	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	CHEMBL260551	96126	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	44393001	64831	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	348	8	3	6	3.7	CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182121	64831	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	348	8	3	6	3.7	CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	71455083	81801	0	None	-100	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164354	81801	0	None	-100	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	22857296	29119	0	None	-9	4	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL13816	29119	0	None	-9	4	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	11573726	71502	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926750	71502	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962912	71502	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	76328896	106245	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121432	106245	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139016	106245	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	71458647	81384	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	9	1	4	4.0	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159457	81384	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	9	1	4	4.0	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	90644063	112008	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	CHEMBL3289648	112008	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	6918542	204901	24	None	-537	10	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00453-4
	CHEMBL76237	204901	24	None	-537	10	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00453-4
	156019939	177957	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646100	177957	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	11575479	94714	0	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	CHEMBL253096	94714	0	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	145978482	163607	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203872	163607	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	168284975	191461	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	404	5	0	6	3.5	COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5193580	191461	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	404	5	0	6	3.5	COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	122483300	138065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765794	138065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765838	138065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	57391158	71528	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949979	71528	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963033	71528	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	122483300	138065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765794	138065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765838	138065	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	168277374	190345	0	None	9	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	441	8	4	6	4.6	Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5177186	190345	0	None	9	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	441	8	4	6	4.6	Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	168291906	192006	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	452	8	0	5	4.8	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	CHEMBL5201984	192006	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	452	8	0	5	4.8	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	66803500	156415	0	None	-24	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	459	8	3	4	4.4	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4066971	156415	0	None	-24	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	459	8	3	4	4.4	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	118736396	118924	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	6	0	10	1.3	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423378	118924	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	6	0	10	1.3	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	162642955	181715	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4777209	181715	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	163196460	192667	3	None	-56	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	394	4	1	7	3.4	CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2022.114645
	CHEMBL5219240	192667	3	None	-56	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	394	4	1	7	3.4	CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2022.114645
	66801837	157504	0	None	-6	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	507	8	2	3	6.1	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	CHEMBL4079972	157504	0	None	-6	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	507	8	2	3	6.1	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	2867758	162018	7	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	339	6	1	2	5.5	Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1	10.1016/j.ejmech.2018.04.010
	CHEMBL4160177	162018	7	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	339	6	1	2	5.5	Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1	10.1016/j.ejmech.2018.04.010
	53377139	66350	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851703	66350	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216068	66350	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
	134130379	142180	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	8	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884137	142180	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	8	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	155568224	176097	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	350	4	1	7	2.2	CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4591878	176097	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	350	4	1	7	2.2	CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	122483251	138078	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764364	138078	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765851	138078	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	122483251	138078	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764364	138078	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765851	138078	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	76328894	106247	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121431	106247	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139018	106247	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	164620912	185711	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	1	4	2.6	OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4866053	185711	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	1	4	2.6	OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	118709755	113519	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	368	8	0	2	5.0	O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321797	113519	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	368	8	0	2	5.0	O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	135398737	955	93	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	38	955	93	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	722	955	93	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	CHEMBL42	955	93	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	DB00363	955	93	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	60165412	75330	0	None	-17	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	379	7	0	5	4.5	O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037530	75330	0	None	-17	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	379	7	0	5	4.5	O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	162666571	182283	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4784167	182283	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	44582707	186974	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490634	186974	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	155519559	170357	0	None	-3162	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1	10.1021/acsmedchemlett.6b00056
	CHEMBL4447846	170357	0	None	-3162	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1	10.1021/acsmedchemlett.6b00056
	71452382	83765	0	None	-199	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205812	83765	0	None	-199	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	127051516	140832	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3819567	140832	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	164619216	185640	0	None	-74	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4864863	185640	0	None	-74	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	118724645	120574	0	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361003	120574	0	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3545907	120574	0	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	2470	3626	50	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3626	50	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3626	50	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3626	50	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3626	50	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	122181345	121861	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590097	121861	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	11566574	71456	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926753	71456	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962487	71456	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
	25125374	177862	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	4.8	CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4644725	177862	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	4.8	CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	164627977	186409	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4876297	186409	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	156022183	178183	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	2	1	2	3.8	CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4649646	178183	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	2	1	2	3.8	CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3	10.1016/j.bmc.2020.115578
	42626361	186755	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL489029	186755	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	42625353	193041	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	393	8	0	4	3.6	COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	CHEMBL522417	193041	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	393	8	0	4	3.6	COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	11348477	126760	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL365412	126760	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	10991109	205144	1	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	329	5	0	2	4.1	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	CHEMBL78218	205144	1	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	329	5	0	2	4.1	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	9979252	98489	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL276206	98489	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	10436045	3490	4	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	782	3490	4	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	CHEMBL432713	3490	4	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	49850872	56428	0	None	-251	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632206	56428	0	None	-251	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	90656714	110940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262390	110940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	37459	743	13	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
	62	743	13	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
	CHEMBL8514	743	13	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
	135	2515	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	1796	2515	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	4184	2515	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	CHEMBL6437	2515	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	DB06148	2515	43	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	9979252	98489	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL276206	98489	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	44268087	20162	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	CHEMBL13049	20162	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	44268087	20162	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL13049	20162	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	117209912	185313	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	185313	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	164627977	186409	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4876297	186409	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL5077178	214464	0	None	-4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)cc1	10.1021/acs.jmedchem.1c00497
	90644063	112008	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	CHEMBL3289648	112008	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	90656714	110940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262390	110940	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	242	469	124	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	34	469	124	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	60795	469	124	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	CHEMBL1112	469	124	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	DB01238	469	124	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	2337	3232	77	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	50	3232	77	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	5002	3232	77	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	CHEMBL716	3232	77	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	DB01224	3232	77	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	9887537	84316	43	None	-79	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL221692	84316	43	None	-79	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL4751170	84316	43	None	-79	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	135	2515	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	1796	2515	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	4184	2515	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	CHEMBL6437	2515	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	DB06148	2515	43	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	37461	17102	14	None	-70	8	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm030841r
	CHEMBL1255588	17102	14	None	-70	8	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm030841r
	90656688	110960	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	338	7	2	4	2.4	NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262420	110960	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	338	7	2	4	2.4	NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	11329254	85187	0	None	2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL225571	85187	0	None	2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	17053	202024	7	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	244	4	1	2	2.8	COc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1021/jm030826m
	CHEMBL608537	202024	7	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	244	4	1	2	2.8	COc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1021/jm030826m
	11485965	45811	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	385	6	0	3	4.4	O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL153132	45811	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	385	6	0	3	4.4	O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	11793826	18020	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	CHEMBL12654	18020	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	11793826	18020	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL12654	18020	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	44368384	44376	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL151858	44376	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	127051516	140832	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3819567	140832	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	9935387	99414	0	None	-794	14	Human	6.2	pKi	=	6.2	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL282971	99414	0	None	-794	14	Human	6.2	pKi	=	6.2	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	90654693	110052	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	388	8	1	5	1.5	COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235730	110052	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	388	8	1	5	1.5	COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	156010396	177103	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	392	5	1	4	4.2	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4633765	177103	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	392	5	1	4	4.2	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	71457264	82592	0	None	-20	6	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	CHEMBL2179217	82592	0	None	-20	6	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	2136365	117901	21	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	0	5	4.5	Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403331	117901	21	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	0	5	4.5	Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL5090884	215554	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096072	215554	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11610908	68014	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1914488	68014	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	145977467	163967	0	None	9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4208185	163967	0	None	9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	117209912	185313	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	185313	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	11432453	85168	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	CHEMBL225441	85168	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	76324975	104988	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113604	104988	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	72549768	114046	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	443	9	1	4	4.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326977	114046	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	443	9	1	4	4.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL5090884	215554	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096072	215554	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	162644013	181815	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4778418	181815	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	162666577	182309	0	None	-47	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4784414	182309	0	None	-47	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	155562519	175188	0	None	-131	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4571321	175188	0	None	-131	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	155541072	172940	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	290	3	2	4	1.7	CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12	10.1039/C8MD00313K
	CHEMBL4517552	172940	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	290	3	2	4	1.7	CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12	10.1039/C8MD00313K
	134134279	143629	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	257	5	1	3	3.1	CNCc1ccc(OC)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3899934	143629	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	257	5	1	3	3.1	CNCc1ccc(OC)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	76332575	106249	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3121416	106249	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3139020	106249	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
	44268087	20162	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	CHEMBL13049	20162	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	76328898	106389	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121440	106389	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139518	106389	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
	145983144	165856	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4249426	165856	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	134154387	152436	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3970994	152436	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	56944863	156695	0	None	-64	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4070254	156695	0	None	-64	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	155540635	172506	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	431	7	1	4	5.4	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4483687	172506	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	431	7	1	4	5.4	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	11431530	84596	0	None	1	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222188	84596	0	None	1	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	168269921	190056	0	None	-218	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	430	8	0	7	3.4	O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5172673	190056	0	None	-218	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	430	8	0	7	3.4	O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	21527771	70127	1	None	-263	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940404	70127	1	None	-263	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	71602687	89655	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376456	89655	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	56850656	71469	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926744	71469	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962584	71469	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	118626088	165377	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238124	165377	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	134154387	152436	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3970994	152436	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	72548349	114060	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326991	114060	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1	10.1016/j.bmc.2014.07.026
	76284725	104986	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113602	104986	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	168295509	192490	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5209283	192490	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	71602687	89655	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376456	89655	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	53323534	56993	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644485	56993	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1	10.1016/j.bmcl.2010.11.078
	46205042	124551	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	CHEMBL3640583	124551	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	46205042	124551	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	CHEMBL3640583	124551	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	155515942	169985	0	None	-331	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	389	3	1	5	3.8	O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21	10.1021/acsmedchemlett.6b00056
	CHEMBL4442456	169985	0	None	-331	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	389	3	1	5	3.8	O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21	10.1021/acsmedchemlett.6b00056
	46233382	200660	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	271	6	0	3	3.3	COc1ccccc1-c1ccccc1OCCN(C)C	10.1016/j.bmc.2010.01.035
	CHEMBL599819	200660	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	271	6	0	3	3.3	COc1ccccc1-c1ccccc1OCCN(C)C	10.1016/j.bmc.2010.01.035
	46204425	124539	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640572	124539	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	46204425	124539	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640572	124539	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	122181335	121851	0	None	-11	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	486	6	1	4	4.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590087	121851	0	None	-11	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	486	6	1	4	4.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	145976408	163854	0	None	10	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	424	5	1	4	3.4	O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4206881	163854	0	None	10	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	424	5	1	4	3.4	O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	145964621	164313	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212539	164313	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	134154680	154538	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3959919	154538	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3991166	154538	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	156022234	178186	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	380	5	1	4	4.2	CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4649697	178186	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	380	5	1	4	4.2	CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	181743	178548	5	None	-33	22	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	CHEMBL467094	178548	5	None	-33	22	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	56944086	112055	0	None	-12	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	420	8	1	7	2.8	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289976	112055	0	None	-12	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	420	8	1	7	2.8	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	134154680	154538	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3959919	154538	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3991166	154538	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL5082267	214772	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(C(F)(F)F)c1	10.1021/acs.jmedchem.1c00497
	145984807	165752	0	None	-134	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	CHEMBL4247275	165752	0	None	-134	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	122483230	138063	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765223	138063	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765836	138063	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	10150497	4043	47	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	3240	4043	47	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	CHEMBL392760	4043	47	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	11494176	71490	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926735	71490	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962803	71490	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
	127041261	136973	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1	10.1016/j.bmc.2015.11.041
	CHEMBL3745975	136973	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1	10.1016/j.bmc.2015.11.041
	57391622	71538	0	None	11	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949970	71538	0	None	11	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963100	71538	0	None	11	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	42625181	193143	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	403	7	1	4	3.4	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1	10.1021/jm8014553
	CHEMBL523121	193143	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	403	7	1	4	3.4	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1	10.1021/jm8014553
	118728513	117682	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401476	117682	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	44424660	85746	0	None	-5	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	454	9	0	9	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229311	85746	0	None	-5	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	454	9	0	9	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	122483230	138063	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765223	138063	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765836	138063	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	44374226	54524	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	188	4	0	4	1.8	CN(C)CCSc1nccs1	10.1016/j.bmcl.2003.11.050
	CHEMBL161031	54524	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	188	4	0	4	1.8	CN(C)CCSc1nccs1	10.1016/j.bmcl.2003.11.050
	11101259	51553	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	392	8	2	5	3.8	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL158332	51553	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	392	8	2	5	3.8	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O	10.1021/jm020994z
	71452383	83767	0	None	-3	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	339	5	1	4	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205814	83767	0	None	-3	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	339	5	1	4	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	145983751	165481	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240642	165481	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	66801537	157908	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4084492	157908	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	57400281	71523	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949965	71523	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963028	71523	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	122178698	121339	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581244	121339	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	42625183	186976	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL490645	186976	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	42625446	188834	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	413	7	0	3	4.7	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL506875	188834	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	413	7	0	3	4.7	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	24771120	184076	0	None	-3019	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	CHEMBL482562	184076	0	None	-3019	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	134150597	152041	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	339	4	0	4	4.3	COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3967387	152041	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	339	4	0	4	4.3	COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	118736372	118918	0	None	-11	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	7	0	9	2.6	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423336	118918	0	None	-11	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	7	0	9	2.6	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	153061504	172786	0	None	-34	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4513930	172786	0	None	-34	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	155533028	171772	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	458	9	0	5	5.1	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4468036	171772	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	458	9	0	5	5.1	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4520788	213952	10	None	-32	25	Human	6.2	pKi	=	6.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
	10090247	205547	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	CHEMBL81276	205547	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	10090247	205547	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81276	205547	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	127026753	137700	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758978	137700	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2015.11.040
	127042185	137042	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	454	8	0	6	3.3	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	CHEMBL3747003	137042	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	454	8	0	6	3.3	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	145985533	165708	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4246202	165708	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983139	165840	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4249179	165840	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71449629	81345	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159321	81345	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	71455000	81394	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159466	81394	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	71449643	81409	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159481	81409	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	145947300	167639	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4170613	167639	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4301924	167639	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	156011936	177378	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	435	8	1	6	4.3	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4638308	177378	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	435	8	1	6	4.3	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	156019026	177772	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	7	4.6	O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4643450	177772	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	7	4.6	O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	60195996	81785	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164338	81785	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	71455000	81394	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1039/C5MD00166H
	CHEMBL2159466	81394	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1039/C5MD00166H
	127038033	136581	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1	10.1039/C5MD00166H
	CHEMBL3739680	136581	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1	10.1039/C5MD00166H
	127039756	136703	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F	10.1039/C5MD00166H
	CHEMBL3740801	136703	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F	10.1039/C5MD00166H
	127039753	136717	0	None	22	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1039/C5MD00166H
	CHEMBL3740913	136717	0	None	22	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1039/C5MD00166H
	42625440	170789	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	CHEMBL445334	170789	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	25256855	189734	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL515939	189734	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	21048816	75471	0	None	30	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	385	7	0	3	4.9	CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL204269	75471	0	None	30	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	385	7	0	3	4.9	CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	11589069	96218	0	None	10	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL260994	96218	0	None	10	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	42625440	170789	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL445334	170789	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm500880c
	42625440	170789	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL445334	170789	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	25256855	189734	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL515939	189734	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2009.02.008
	11145126	204378	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	5	1	4	4.9	CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71959	204378	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	5	1	4	4.9	CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	60196077	81790	0	None	20	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	CHEMBL2164343	81790	0	None	20	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	132525569	164025	0	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	272	3	0	5	2.1	CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	CHEMBL4208934	164025	0	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	272	3	0	5	2.1	CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	24768516	92557	0	None	11	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243523	92557	0	None	11	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	44374207	52468	0	None	5	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	280	5	1	4	2.9	CN(C)CCSc1cccc(C2(O)CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL159143	52468	0	None	5	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	280	5	1	4	2.9	CN(C)CCSc1cccc(C2(O)CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	9911844	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/j.ejmech.2019.111705
	CHEMBL348890	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/j.ejmech.2019.111705
	9911844	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL348890	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	9911844	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL348890	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	162654006	180466	0	None	-29	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	CHEMBL4753094	180466	0	None	-29	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	162643812	181639	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4776225	181639	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	9911844	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1021/jm070279v
	CHEMBL348890	119844	1	None	43	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1021/jm070279v
	10873805	204671	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1	10.1021/jm0200411
	CHEMBL73979	204671	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1	10.1021/jm0200411
	5	139	72	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	5202	139	72	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	CHEMBL39	139	72	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	DB08839	139	72	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	35985234	88317	15	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	211	3	1	1	3.2	Cc1ccccc1-c1cccc(CCN)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL234885	88317	15	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	211	3	1	1	3.2	Cc1ccccc1-c1cccc(CCN)c1	10.1016/j.bmcl.2007.03.054
	145976433	163906	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	372	6	0	3	4.7	COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL4207454	163906	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	372	6	0	3	4.7	COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1	10.1021/acs.jmedchem.7b01898
	155522867	170802	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	401	8	1	6	3.5	COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	CHEMBL4453552	170802	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	401	8	1	6	3.5	COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	118713686	114364	0	None	-28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	5	4.8	O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331389	114364	0	None	-28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	5	4.8	O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	168271960	190084	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5173014	190084	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	11395034	71470	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926751	71470	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962585	71470	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	16747715	151019	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmc.2010.01.035
	CHEMBL395870	151019	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmc.2010.01.035
	16747715	151019	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL395870	151019	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	11515799	156915	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	348	6	1	2	4.5	CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL407263	156915	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	348	6	1	2	4.5	CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	136152971	95328	0	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL256694	95328	0	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	118713687	114366	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	423	10	0	6	4.4	COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331390	114366	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	423	10	0	6	4.4	COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	164621627	185459	0	None	-10	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4862180	185459	0	None	-10	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	118713588	114346	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	397	7	0	6	3.7	COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331257	114346	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	397	7	0	6	3.7	COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	10429067	123604	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	CHEMBL361875	123604	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	10429067	123604	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	CHEMBL361875	123604	0	None	43	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	10257	735	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	144	735	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	CHEMBL416526	735	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	DB01445	735	31	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	10884517	102226	1	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	1	4	4.4	CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL303166	102226	1	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	1	4	4.4	CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	206	2476	16	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
	68848	2476	16	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
	CHEMBL12314	2476	16	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
	11391654	180501	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	180501	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	5	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	5202	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	CHEMBL39	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	DB08839	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	9954003	71671	24	None	-15	9	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	CHEMBL196514	71671	24	None	-15	9	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	197033	199129	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589390	199129	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	206	2476	16	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
	68848	2476	16	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
	CHEMBL12314	2476	16	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
	46205374	124562	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640594	124562	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	168268877	189946	0	None	-1	12	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189946	0	None	-1	12	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	46205374	124562	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640594	124562	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	100	3776	58	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	2637	3776	58	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	5452	3776	58	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	CHEMBL479	3776	58	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	DB00679	3776	58	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	44460917	104383	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	297	4	0	3	3.3	C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL310317	104383	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	297	4	0	3	3.3	C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	44460980	205917	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL84270	205917	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	76321737	106392	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121428	106392	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139525	106392	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	127026132	137821	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	2.9	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3760010	137821	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	2.9	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	127041260	137031	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	430	7	0	4	4.1	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	CHEMBL3746806	137031	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	430	7	0	4	4.1	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	90654838	112660	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233668	112660	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304237	112660	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	155545625	173437	0	None	102	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	255	4	1	3	3.5	CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1	10.1016/j.ejmech.2019.03.017
	CHEMBL4529615	173437	0	None	102	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	255	4	1	3	3.5	CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1	10.1016/j.ejmech.2019.03.017
	56944864	157536	0	None	-27	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	8	2	3	5.0	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4080369	157536	0	None	-27	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	8	2	3	5.0	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	135367816	164811	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	145947937	167699	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4207653	167699	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302655	167699	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	11478226	136915	0	None	12	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL374297	136915	0	None	12	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	57399494	70428	0	None	-1	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL1946124	70428	0	None	-1	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	135367816	164811	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	11430856	77992	32	None	-134	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	CHEMBL209821	77992	32	None	-134	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	127035062	136426	0	None	-23	19	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136426	0	None	-23	19	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	11261344	169284	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	476	9	1	6	4.7	COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1	10.1021/jm049702f
	CHEMBL441560	169284	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	476	9	1	6	4.7	COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1	10.1021/jm049702f
	135367858	163757	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4205846	163757	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	216239	23763	118	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1200485	23763	118	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1336	23763	118	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	155560943	176543	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4574931	176543	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4597364	176543	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	10698929	99326	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	607	5	0	7	5.6	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm0108505
	CHEMBL282413	99326	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	607	5	0	7	5.6	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm0108505
	71449628	81340	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	404	7	1	3	4.4	O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159317	81340	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	404	7	1	3	4.4	O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	122181251	121829	0	None	-27	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	448	7	1	5	3.0	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3589977	121829	0	None	-27	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	448	7	1	5	3.0	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	156022244	177197	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4635538	177197	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	76280896	104985	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113601	104985	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	25107583	192853	0	None	-2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	CHEMBL522194	192853	0	None	-2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	155533648	171861	0	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	486	9	0	6	4.7	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4469539	171861	0	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	486	9	0	6	4.7	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	155564824	175506	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay	ChEMBL	412	4	3	6	3.9	C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b00689
	CHEMBL4578381	175506	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay	ChEMBL	412	4	3	6	3.9	C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b00689
	145954503	162395	0	None	-7	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	370	5	1	4	4.1	O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4166092	162395	0	None	-7	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	370	5	1	4	4.1	O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1	10.1016/j.ejmech.2018.04.010
	168288598	191749	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	400	10	3	9	1.8	COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5197911	191749	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	400	10	3	9	1.8	COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	44278114	100177	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	334	5	1	3	3.8	CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL28833	100177	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	334	5	1	3	3.8	CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	126720425	162090	0	None	-354	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	369	4	1	5	3.7	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4161308	162090	0	None	-354	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	369	4	1	5	3.7	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	135367858	163757	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4205846	163757	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	127027386	137638	0	None	5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	8	1	5	3.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758466	137638	0	None	5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	8	1	5	3.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1	10.1016/j.ejmech.2015.11.040
	156013612	177204	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	452	9	0	7	5.9	c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1	10.1016/j.bmc.2020.115459
	CHEMBL4635603	177204	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	452	9	0	7	5.9	c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1	10.1016/j.bmc.2020.115459
	90654840	112607	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233669	112607	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302757	112607	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
	57399494	70428	0	None	-1	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL1946124	70428	0	None	-1	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	54758202	65979	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	CHEMBL1836858	65979	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	10895284	103082	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	430	7	1	3	5.0	CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL307686	103082	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	430	7	1	3	5.0	CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	117209964	186110	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186110	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	52952308	62550	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	6	1	5	4.6	N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782793	62550	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	6	1	5	4.6	N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	90654680	110074	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235752	110074	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	46206022	124576	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640608	124576	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	46206022	124576	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640608	124576	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	155538451	172363	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	485	10	0	5	5.2	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4476432	172363	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	485	10	0	5	5.2	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	117209964	186110	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186110	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	156019279	177949	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	338	3	0	4	3.5	COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4645997	177949	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	338	3	0	4	3.5	COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	134157289	154057	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	154057	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	44455943	168978	5	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL439240	168978	5	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	118724637	120588	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360997	120588	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546115	120588	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	44582705	186972	0	None	-4	13	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490632	186972	0	None	-4	13	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	155563374	175222	0	None	-831	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	423	3	1	5	4.5	O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21	10.1021/acsmedchemlett.6b00056
	CHEMBL4572158	175222	0	None	-831	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	423	3	1	5	4.5	O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21	10.1021/acsmedchemlett.6b00056
	53376041	66341	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851658	66341	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3215835	66341	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
	134133064	144710	0	None	4	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	CHEMBL3908870	144710	0	None	4	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	122483223	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	56850387	71449	0	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1926731	71449	0	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1962455	71449	0	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
	127026071	137735	0	None	25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	4.5	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759298	137735	0	None	25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	4.5	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	145963860	164202	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4211091	164202	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	155525703	171029	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	452	8	1	8	1.6	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4456962	171029	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	452	8	1	8	1.6	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	10950559	203942	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1016/j.bmc.2019.06.028
	CHEMBL69388	203942	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1016/j.bmc.2019.06.028
	122483223	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	42626293	151101	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	349	6	0	3	3.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL395933	151101	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	349	6	0	3	3.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	11200511	201707	0	None	-74	8	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
	CHEMBL606547	201707	0	None	-74	8	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
	127036932	137323	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3752900	137323	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	10950559	203942	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1021/jm0104264
	CHEMBL69388	203942	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1021/jm0104264
	122483223	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	138084	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	162662367	182020	0	None	18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	531	10	0	5	7.7	COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4781056	182020	0	None	18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	531	10	0	5	7.7	COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	156015306	177590	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4640899	177590	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	156020091	178164	0	None	-8	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649327	178164	0	None	-8	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	145977338	163693	0	None	-74	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	CHEMBL4205064	163693	0	None	-74	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	156021059	178113	0	None	-147	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	8	3.5	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12	10.1016/j.bmc.2020.115459
	CHEMBL4648581	178113	0	None	-147	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	8	3.5	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12	10.1016/j.bmc.2020.115459
	11257767	67001	9	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	389	7	1	5	2.1	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	CHEMBL187088	67001	9	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	389	7	1	5	2.1	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	11325873	125769	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	360	7	1	4	2.4	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2	10.1021/jm049743b
	CHEMBL364795	125769	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	360	7	1	4	2.4	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2	10.1021/jm049743b
	118626042	165546	0	None	-9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242170	165546	0	None	-9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	162666794	183708	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4784726	183708	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803549	183708	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	155556806	174506	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	381	7	1	4	4.3	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4555702	174506	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	381	7	1	4	4.3	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	164628817	186253	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	CHEMBL4874069	186253	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	44391622	65962	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	333	3	0	3	4.4	COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12	10.1016/j.bmcl.2004.11.013
	CHEMBL183676	65962	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	333	3	0	3	4.4	COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12	10.1016/j.bmcl.2004.11.013
	46204424	124538	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	CHEMBL3640571	124538	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	46204424	124538	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	CHEMBL3640571	124538	7	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	156020902	178005	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	378	5	0	4	4.3	COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4646861	178005	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	378	5	0	4	4.3	COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	53320866	56994	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644486	56994	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	10383646	18730	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277917	18730	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	46205043	124552	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	CHEMBL3640584	124552	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	46205043	124552	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	CHEMBL3640584	124552	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	127051843	140726	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140726	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	127051843	140726	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140726	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	46204084	124527	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	CHEMBL3640560	124527	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	46204084	124527	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	CHEMBL3640560	124527	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	134135516	144148	0	None	7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3904094	144148	0	None	7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	25107582	187560	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	CHEMBL494661	187560	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	122196373	124261	0	None	-34	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	CHEMBL3634813	124261	0	None	-34	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	122181342	121858	0	None	-25	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590094	121858	0	None	-25	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	118731354	118164	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	10	0	4	4.9	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409037	118164	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	10	0	4	4.9	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	57392825	68368	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL1916744	68368	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL3233402	68368	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	71602739	89661	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376462	89661	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	164628817	186253	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	CHEMBL4874069	186253	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	56649649	67828	0	None	-91	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910140	67828	0	None	-91	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	59511191	185499	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185499	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	90656689	110959	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	7	1	5	3.1	COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262419	110959	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	7	1	5	3.1	COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	46204085	124528	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640561	124528	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	46204085	124528	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640561	124528	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	134148917	148399	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	285	4	0	4	3.2	COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3937741	148399	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	285	4	0	4	3.2	COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	35391328	68382	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	316	5	1	3	2.0	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917332	68382	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	316	5	1	3	2.0	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	155535879	176645	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4472629	176645	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4598209	176645	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
	127052488	140774	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	CHEMBL3818799	140774	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	90654672	110066	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235744	110066	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	42428409	68381	6	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	366	5	1	3	3.2	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917331	68381	6	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	366	5	1	3	3.2	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	71451455	81389	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	9	1	5	4.1	CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159461	81389	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	9	1	5	4.1	CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	90654672	110066	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3235744	110066	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	90654856	112666	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233677	112666	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304304	112666	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
	59511191	185499	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185499	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	164621627	185459	0	None	-10	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4862180	185459	0	None	-10	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	42618266	191055	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	408	9	1	5	3.7	COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL518752	191055	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	408	9	1	5	3.7	COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	11266074	66236	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	283	3	1	3	3.2	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2	10.1021/jm0498102
	CHEMBL184666	66236	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	283	3	1	3	3.2	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2	10.1021/jm0498102
	75201901	166401	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44439389	91751	0	None	8	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	324	3	1	5	2.8	COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C	10.1016/j.bmcl.2007.01.093
	CHEMBL241099	91751	0	None	8	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	324	3	1	5	2.8	COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C	10.1016/j.bmcl.2007.01.093
	146680920	171850	0	None	-2570	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12	10.1021/acsmedchemlett.6b00056
	CHEMBL4469309	171850	0	None	-2570	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12	10.1021/acsmedchemlett.6b00056
	168269719	189987	0	None	-2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	444	7	3	8	2.9	COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5171456	189987	0	None	-2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	444	7	3	8	2.9	COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	127029652	138303	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771222	138303	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	57399089	68391	0	None	-21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917341	68391	0	None	-21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmc.2011.09.044
	127029652	138303	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.bmcl.2018.02.003
	127029652	138303	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL3771222	138303	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.bmcl.2018.02.003
	CHEMBL3771222	138303	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	134154531	152704	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152704	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	9843889	16274	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12259	16274	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	49850874	56432	0	None	-251	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632210	56432	0	None	-251	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	11397149	56445	0	None	-251	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632223	56445	0	None	-251	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	75306277	109227	0	None	-39	23	Human	7.1	pKi	=	7.1	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	CHEMBL3217984	109227	0	None	-39	23	Human	7.1	pKi	=	7.1	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	281	3484	28	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	5312148	3484	28	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	CHEMBL12264	3484	28	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	9843889	16274	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL12259	16274	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	71602739	89661	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376462	89661	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	117209911	186305	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186305	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	6540428	184840	1	None	-19	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
	CHEMBL3989558	184840	1	None	-19	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
	CHEMBL485253	184840	1	None	-19	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
	9804612	90506	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238730	90506	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	44439167	90528	0	None	-7	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238732	90528	0	None	-7	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	135398745	2893	112	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	47	2893	112	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	CHEMBL715	2893	112	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	DB00334	2893	112	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	76518515	140845	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3818881	140845	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819714	140845	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	60167166	75266	0	None	-25	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037430	75266	0	None	-25	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	44395796	66932	0	None	-5	2	Rat	6.1	pKi	=	6.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL186734	66932	0	None	-5	2	Rat	6.1	pKi	=	6.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	164613297	184593	0	None	-19	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4849230	184593	0	None	-19	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	13702393	155001	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	CHEMBL401541	155001	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	CHEMBL556983	155001	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	122483249	138069	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764970	138069	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765842	138069	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	127052488	140774	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	CHEMBL3818799	140774	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	168287126	191541	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	414	6	3	7	2.9	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5194826	191541	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	414	6	3	7	2.9	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	162671691	183737	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4792268	183737	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803838	183737	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	136118730	76215	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	CHEMBL2058407	76215	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	162647425	179553	1	None	-208	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis	ChEMBL	584	13	0	7	5.3	C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2020.112765
	CHEMBL4741978	179553	1	None	-208	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis	ChEMBL	584	13	0	7	5.3	C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2020.112765
	10154897	65233	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182797	65233	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	44393075	65697	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	7	3	6	3.4	CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL183462	65697	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	7	3	6	3.4	CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	197033	199129	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2021.128275
	CHEMBL589390	199129	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2021.128275
	197033	199129	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.ejmech.2009.10.035
	CHEMBL589390	199129	64	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.ejmech.2009.10.035
	11199511	75404	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2009.06.038
	CHEMBL204171	75404	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2009.06.038
	56850385	71448	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1926730	71448	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1962454	71448	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
	44408833	74423	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL202780	74423	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	168282454	191191	0	None	3	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	485	11	4	8	3.6	Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5189648	191191	0	None	3	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	485	11	4	8	3.6	Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	168292411	191866	0	None	8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	8	2.8	Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5199820	191866	0	None	8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	8	2.8	Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	145984065	165727	0	None	1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4246630	165727	0	None	1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	134141166	146732	0	None	15	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	496	11	1	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3924375	146732	0	None	15	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	496	11	1	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	145946956	167571	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4166804	167571	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4300883	167571	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	155551353	173938	0	None	51	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	323	1	1	2	3.2	Cn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4541526	173938	0	None	51	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	323	1	1	2	3.2	Cn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	127041108	136570	0	None	12	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12	10.1039/C5MD00166H
	CHEMBL3739582	136570	0	None	12	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12	10.1039/C5MD00166H
	127037679	136650	0	None	18	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1	10.1039/C5MD00166H
	CHEMBL3740235	136650	0	None	18	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1	10.1039/C5MD00166H
	127040760	136866	0	None	22	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1039/C5MD00166H
	CHEMBL3742251	136866	0	None	22	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1039/C5MD00166H
	11391654	180501	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	180501	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	44408833	74423	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL202780	74423	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	11199511	75404	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL204171	75404	0	None	4	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2005.11.067
	90656693	112653	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262432	112653	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304130	112653	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	90656693	112653	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262432	112653	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304130	112653	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	5	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	5202	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	CHEMBL39	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	DB08839	139	72	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	10949445	164981	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	402	6	2	3	4.9	O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL422587	164981	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	402	6	2	3	4.9	O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	46203757	124521	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	CHEMBL3640555	124521	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	46203757	124521	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	CHEMBL3640555	124521	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	60196078	81776	2	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	CHEMBL2164328	81776	2	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	16006606	157637	3	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	CHEMBL408152	157637	3	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	24854040	161221	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	CHEMBL411919	161221	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	25107647	187460	0	None	11	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	10.1021/jm800615e
	CHEMBL494118	187460	0	None	11	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	10.1021/jm800615e
	44319435	206091	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	346	4	1	2	4.1	O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL85814	206091	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	346	4	1	2	4.1	O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	164609529	184440	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	184440	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	24964217	87185	0	None	63	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	255	5	0	2	3.5	COc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL232792	87185	0	None	63	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	255	5	0	2	3.5	COc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	132547279	142176	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	434	9	0	6	4.1	CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884095	142176	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	434	9	0	6	4.1	CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1	10.1016/j.bmc.2016.12.039
	118713688	114367	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	439	10	0	6	4.8	COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331391	114367	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	439	10	0	6	4.8	COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL5093342	215541	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215541	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	164609529	184440	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	184440	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	10404657	98041	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	CHEMBL273241	98041	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	24963860	87184	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	CHEMBL232791	87184	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	10404657	98041	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	CHEMBL273241	98041	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	24963860	87184	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL232791	87184	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	25107580	187489	0	None	2	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	CHEMBL494312	187489	0	None	2	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	72550642	114051	0	None	2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326982	114051	0	None	2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL5093342	215541	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215541	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	76325353	106393	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121438	106393	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139528	106393	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	16093484	98032	6	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL273170	98032	6	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	10939416	204192	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	456	7	2	4	3.9	NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL70889	204192	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	456	7	2	4	3.9	NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	11729823	102944	1	None	-16	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1	10.1021/jm0200411
	CHEMBL306478	102944	1	None	-16	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1	10.1021/jm0200411
	66801028	112076	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	8	1	6	4.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289997	112076	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	8	1	6	4.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	6603866	97400	17	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
	CHEMBL26998	97400	17	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
	CHEMBL541268	97400	17	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
	46204427	124540	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640573	124540	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	46204427	124540	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640573	124540	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	44327952	208021	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	CHEMBL97518	208021	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	21091965	68383	9	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	380	6	1	3	3.6	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917333	68383	9	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	380	6	1	3	3.6	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	60196075	81788	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2cccc(N3CCNCC3)c2)nc1	10.1021/jm3003679
	CHEMBL2164341	81788	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2cccc(N3CCNCC3)c2)nc1	10.1021/jm3003679
	66801528	156819	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4071451	156819	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	66801052	158934	0	None	-18	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4095979	158934	0	None	-18	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	3084440	159791	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmcl.2007.01.093
	CHEMBL410604	159791	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmcl.2007.01.093
	76518515	140845	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3818881	140845	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819714	140845	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	44401041	70458	0	None	-18	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL194659	70458	0	None	-18	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	46205698	124567	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	CHEMBL3640599	124567	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	46205698	124567	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	CHEMBL3640599	124567	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	155526014	171040	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.9	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4457095	171040	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.9	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	44439387	91688	0	None	38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	276	2	1	2	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL240888	91688	0	None	38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	276	2	1	2	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	11773414	147260	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	380	4	1	4	4.2	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL392887	147260	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	380	4	1	4	4.2	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	1984087	162273	10	None	-2	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	3	5.3	COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4164250	162273	10	None	-2	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	3	5.3	COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1	10.1016/j.ejmech.2018.04.010
	135	2515	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	1796	2515	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	4184	2515	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	CHEMBL6437	2515	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	DB06148	2515	43	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	24768526	93202	0	None	-41	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL244792	93202	0	None	-41	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	117209911	186305	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186305	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	9992778	16227	0	None	-2	3	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL122453	16227	0	None	-2	3	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	90656673	110944	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	308	2	1	3	3.1	Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2	10.1016/j.ejmech.2014.04.034
	CHEMBL3262398	110944	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	308	2	1	3	3.1	Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2	10.1016/j.ejmech.2014.04.034
	130442480	175246	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	18377415	206099	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL85897	206099	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	71453156	81141	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	6	1	3	5.3	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158036	81141	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	6	1	3	5.3	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2012.07.043
	24768521	92983	0	None	-19	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244162	92983	0	None	-19	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	11178340	84666	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222604	84666	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	155520499	170460	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	494	9	0	6	4.6	O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4449148	170460	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	494	9	0	6	4.6	O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	145986720	167219	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	436	7	2	5	2.1	CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4292541	167219	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	436	7	2	5	2.1	CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4777443	214023	0	None	-39	14	Human	6.1	pKi	=	6.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
	58405078	110669	0	None	2	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	CHEMBL3260335	110669	0	None	2	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	1342	36	49	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
	3	36	49	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
	CHEMBL277120	36	49	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
	44327952	208021	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	CHEMBL97518	208021	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	44424665	85687	0	None	5	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL228882	85687	0	None	5	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	1342	36	49	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
	3	36	49	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
	CHEMBL277120	36	49	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
	122483212	138072	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763858	138072	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765845	138072	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	122483212	138072	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763858	138072	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765845	138072	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	155543653	173171	0	None	-70	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4522568	173171	0	None	-70	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	127028799	138213	0	None	6	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770293	138213	0	None	6	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	435595	55272	14	None	10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	238	4	0	4	3.0	CN(C)CCSc1nc2ccccc2s1	10.1016/j.bmcl.2003.11.050
	CHEMBL161846	55272	14	None	10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	238	4	0	4	3.0	CN(C)CCSc1nc2ccccc2s1	10.1016/j.bmcl.2003.11.050
	129211	3722	78	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	2562	3722	78	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	488	3722	78	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	CHEMBL836	3722	78	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	DB00706	3722	78	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	127038282	137057	0	None	67	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	7	1	6	2.5	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.ejmech.2015.11.040
	CHEMBL3747117	137057	0	None	67	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	7	1	6	2.5	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.ejmech.2015.11.040
	155567307	175918	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	457	10	0	4	5.6	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4587772	175918	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	457	10	0	4	5.6	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/j.bmcl.2019.06.029
	156013695	177246	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4636210	177246	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	90656678	110952	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	6	0	3	3.6	Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262412	110952	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	6	0	3	3.6	Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	44414722	80325	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	296	5	1	3	2.9	COc1ccccc1CC(c1ccccc1)N1CCNCC1	10.1016/j.bmcl.2010.04.052
	CHEMBL214335	80325	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	296	5	1	3	2.9	COc1ccccc1CC(c1ccccc1)N1CCNCC1	10.1016/j.bmcl.2010.04.052
	2477	742	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	36	742	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	437	742	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	CHEMBL49	742	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	DB00490	742	59	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	2928642	162265	9	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	7	1	2	6.1	Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4164143	162265	9	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	7	1	2	6.1	Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	2962174	162947	10	None	-44	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	410	5	1	4	4.2	O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F	10.1016/j.ejmech.2018.04.010
	CHEMBL4174981	162947	10	None	-44	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	410	5	1	4	4.2	O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F	10.1016/j.ejmech.2018.04.010
	44276170	96288	0	None	-25	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	0	5	3.9	COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	CHEMBL26135	96288	0	None	-25	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	0	5	3.9	COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	71456770	81336	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159313	81336	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	145946620	167532	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4174681	167532	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4300388	167532	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	155548275	173765	0	None	-79	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	426	5	2	5	4.1	CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1	10.1016/j.ejmech.2019.06.001
	CHEMBL4537701	173765	0	None	-79	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	426	5	2	5	4.1	CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1	10.1016/j.ejmech.2019.06.001
	144950987	179946	0	None	-707	6	Human	4.1	pKi	=	4.1	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
	CHEMBL4746800	179946	0	None	-707	6	Human	4.1	pKi	=	4.1	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
	37219401	137805	4	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	378	7	1	4	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759874	137805	4	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	378	7	1	4	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	164618100	185336	0	None	-128	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4860275	185336	0	None	-128	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	164612518	185370	0	None	-41	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4860719	185370	0	None	-41	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	122483275	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	145975289	163555	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203295	163555	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	122483275	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	127050699	140847	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819082	140847	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819726	140847	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	21071390	1974	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	8689	1974	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	CHEMBL3286580	1974	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	DB11957	1974	53	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	42618255	181552	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	CHEMBL476862	181552	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	71454898	81130	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	467	7	1	4	5.9	O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158025	81130	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	467	7	1	4	5.9	O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	162671167	183733	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4790826	183733	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803803	183733	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	56850926	71460	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926759	71460	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962491	71460	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	134142907	145274	0	None	39	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3913100	145274	0	None	39	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	4431	2710	25	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
	73	2710	25	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
	CHEMBL8618	2710	25	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
	118706290	120507	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310116	120507	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545468	120507	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	4431	2710	25	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
	73	2710	25	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
	CHEMBL8618	2710	25	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
	15629493	202023	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	233	4	0	2	2.9	CCN(CC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	CHEMBL608536	202023	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	233	4	0	2	2.9	CCN(CC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	122483275	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	3037629	184548	18	None	-21	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4848517	184548	18	None	-21	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	52952421	62552	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	479	6	1	6	5.5	O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1	10.1021/jm2000773
	CHEMBL1782795	62552	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	479	6	1	6	5.5	O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1	10.1021/jm2000773
	51352628	82798	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	CHEMBL2180408	82798	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	155530779	171546	0	None	-11	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1	10.1016/j.ejmech.2019.111857
	CHEMBL4464881	171546	0	None	-11	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1	10.1016/j.ejmech.2019.111857
	71462068	81144	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	443	6	1	4	4.8	O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158039	81144	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	443	6	1	4	4.8	O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	51352628	82798	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	CHEMBL2180408	82798	10	None	-4	3	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of 5-HT7AGPCRScan assay: inhibition of 5-HT7A	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	126720394	162290	0	None	-1230	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	355	4	1	5	3.1	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4164541	162290	0	None	-1230	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	355	4	1	5	3.1	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	10421583	99155	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm9911433
	CHEMBL281357	99155	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm9911433
	44460808	205524	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81041	205524	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1	10.1016/s0960-894x(02)00438-9
	21092408	68398	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917348	68398	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	57395084	71522	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949964	71522	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963027	71522	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
	10421583	99155	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm0108505
	CHEMBL281357	99155	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm0108505
	118728528	117698	0	None	-27	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401491	117698	0	None	-27	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	135367404	164531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4215197	164531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	118709751	113514	0	None	-691	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	CHEMBL3321792	113514	0	None	-691	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	122483249	138069	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764970	138069	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765842	138069	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	135367817	163531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4202995	163531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	32354149	164369	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4213238	164369	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	47556338	166789	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	397	5	2	4	2.0	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O	10.1039/C8MD00168E
	CHEMBL4284656	166789	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	397	5	2	4	2.0	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O	10.1039/C8MD00168E
	9843889	16274	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.7b01898
	CHEMBL12259	16274	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.7b01898
	127028153	138138	0	None	33	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769441	138138	0	None	33	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	156015769	177555	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	388	4	1	5	2.8	COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640588	177555	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	388	4	1	5	2.8	COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	9843889	16274	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL12259	16274	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	9843889	16274	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL12259	16274	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	145946714	167534	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4213352	167534	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300399	167534	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	50878551	90716	61	None	1	18	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL2391541	90716	61	None	1	18	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	242	469	124	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	34	469	124	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	60795	469	124	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	CHEMBL1112	469	124	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	DB01238	469	124	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	135367817	163531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4202995	163531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	135367404	164531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4215197	164531	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	155512487	169645	3	None	-446	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4437523	169645	3	None	-446	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	12088082	65096	0	None	17	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	7	3	7	2.8	C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182418	65096	0	None	17	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	7	3	7	2.8	C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	44461048	168138	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	5	0	3	3.8	Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL433134	168138	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	5	0	3	3.8	Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	135398737	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	38	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	722	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	CHEMBL42	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	DB00363	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	127025244	137730	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759262	137730	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	127041244	137047	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	416	8	0	4	4.0	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747052	137047	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	416	8	0	4	4.0	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	145984299	165728	0	None	-63	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4246655	165728	0	None	-63	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71456782	81407	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	364	7	1	4	2.3	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159479	81407	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	364	7	1	4	2.3	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	71453280	81411	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	CHEMBL2159483	81411	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	118731363	118173	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	566	8	0	5	4.5	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409046	118173	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	566	8	0	5	4.5	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	118731364	118174	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	578	9	0	4	6.0	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409047	118174	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	578	9	0	4	6.0	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	118731366	118176	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	594	10	0	5	5.2	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409049	118176	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	594	10	0	5	5.2	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	145947456	167626	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4174055	167626	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4301717	167626	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	156017281	177641	0	None	-8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	466	8	0	6	4.0	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4641609	177641	0	None	-8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	466	8	0	6	4.0	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	122377930	136627	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1039/C5MD00166H
	CHEMBL3740054	136627	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1039/C5MD00166H
	127041107	136776	0	None	8	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12	10.1039/C5MD00166H
	CHEMBL3741445	136776	0	None	8	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12	10.1039/C5MD00166H
	11460460	182338	0	None	-8	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784845	182338	0	None	-8	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	66800947	158209	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4088249	158209	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	11397799	84704	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL222864	84704	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	11326570	76691	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	383	7	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206563	76691	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	383	7	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	44326733	111602	0	None	512	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	2	2	3	3.3	c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3	10.1016/j.bmcl.2007.01.093
	CHEMBL328476	111602	0	None	512	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	2	2	3	3.3	c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3	10.1016/j.bmcl.2007.01.093
	66801605	112038	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	520	8	1	7	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289960	112038	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	520	8	1	7	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	25107579	187418	0	None	-1	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	CHEMBL493909	187418	0	None	-1	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	24854266	96221	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	CHEMBL261009	96221	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	24854266	96221	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	CHEMBL261009	96221	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	155567476	175874	0	None	251	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	450	7	1	6	4.4	O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4586787	175874	0	None	251	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	450	7	1	6	4.4	O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	10324985	76752	8	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76752	8	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76752	8	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	44266244	208049	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	378	5	0	3	3.9	Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1	10.1016/s0960-894x(03)00077-5
	CHEMBL9770	208049	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	378	5	0	3	3.9	Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1	10.1016/s0960-894x(03)00077-5
	CHEMBL5074880	214316	0	None	1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	44266164	207163	0	None	19	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	423	4	0	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9250	207163	0	None	19	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	423	4	0	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	155515687	169946	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	452	6	1	5	4.9	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4441943	169946	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	452	6	1	5	4.9	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	24854270	95825	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	CHEMBL259009	95825	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	134136134	144412	0	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	584	15	1	6	5.5	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3906408	144412	0	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	584	15	1	6	5.5	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	156020950	178098	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4648289	178098	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	11525867	96197	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm200547z
	CHEMBL260870	96197	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm200547z
	66801160	112025	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289947	112025	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	1621	2413	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	17	2413	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	5761	2413	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	CHEMBL263881	2413	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	DB04829	2413	17	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	118753672	120592	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
	CHEMBL2413451	120592	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
	CHEMBL3546228	120592	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
	11740526	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
	CHEMBL2311141	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
	CHEMBL85602	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
	11740526	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
	CHEMBL2311141	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
	CHEMBL85602	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
	11740526	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	CHEMBL2311141	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	CHEMBL85602	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	162647173	179607	0	None	-2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4742856	179607	0	None	-2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	11740526	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
	CHEMBL2311141	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
	CHEMBL85602	206064	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
	10064053	95878	0	None	-5	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm030030n
	CHEMBL25924	95878	0	None	-5	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm030030n
	10064053	95878	0	None	-5	6	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm0108505
	CHEMBL25924	95878	0	None	-5	6	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm0108505
	2470	3626	50	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3626	50	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3626	50	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3626	50	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3626	50	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	156016177	177630	0	None	18	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	CHEMBL4641502	177630	0	None	18	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	66801173	112036	0	None	-1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	486	8	1	7	4.4	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289958	112036	0	None	-1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	486	8	1	7	4.4	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	66801226	112050	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	7	1	6	3.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289971	112050	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	7	1	6	3.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	3994476	98948	9	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL279841	98948	9	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.ejmech.2021.113931
	57399091	68394	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917344	68394	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	11380477	179658	0	None	-17	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4743582	179658	0	None	-17	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	11288612	182587	0	None	-29	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4788327	182587	0	None	-29	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	44209480	70141	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL1940418	70141	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2020.115943
	56944862	156744	0	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4070715	156744	0	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	44209480	70141	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL1940418	70141	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	44209480	70141	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	CHEMBL1940418	70141	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	145947560	167684	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4212812	167684	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4302457	167684	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	3994476	98948	9	None	-13	5	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL279841	98948	9	None	-13	5	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	90656671	110963	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	7	1	4	4.7	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262423	110963	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	7	1	4	4.7	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	90644078	112062	0	None	-29	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	490	7	1	7	4.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289983	112062	0	None	-29	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	490	7	1	7	4.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	145963863	164203	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4211094	164203	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	42618254	181992	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2009.02.008
	CHEMBL478073	181992	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2009.02.008
	127029375	138237	0	None	4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770522	138237	0	None	4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	134155461	154463	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3959209	154463	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3990475	154463	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	66800965	158170	0	None	-50	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4087852	158170	0	None	-50	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	134155461	154463	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3959209	154463	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3990475	154463	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	156011357	177314	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	387	2	0	1	5.8	CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4637353	177314	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	387	2	0	1	5.8	CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	44395797	66756	0	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	6	0	5	2.7	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL185936	66756	0	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	6	0	5	2.7	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	155566855	176218	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4586353	176218	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4594758	176218	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	52952307	62559	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	477	7	1	6	5.7	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782806	62559	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	477	7	1	6	5.7	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12	10.1021/jm2000773
	52952200	62554	0	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	413	6	0	6	4.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	CHEMBL1782798	62554	0	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	413	6	0	6	4.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	118709750	113513	0	None	-83	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321791	113513	0	None	-83	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	76310813	106370	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121433	106370	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139442	106370	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
	11454449	84695	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	7	1	4	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222807	84695	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	7	1	4	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	44401042	124803	0	None	-24	9	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL364270	124803	0	None	-24	9	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	90656670	110964	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	401	8	1	4	4.6	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262424	110964	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	401	8	1	4	4.6	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	155554036	174177	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4548041	174177	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	162671630	183736	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4791207	183736	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803834	183736	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	66801053	183412	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	470	8	2	7	3.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12	10.1016/j.ejmech.2020.112437
	CHEMBL4798767	183412	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	470	8	2	7	3.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12	10.1016/j.ejmech.2020.112437
	122181250	121828	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	418	6	1	4	3.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3589976	121828	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	418	6	1	4	3.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	71460453	81333	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	488	8	1	4	5.2	O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159310	81333	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	488	8	1	4	5.2	O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	60195994	81783	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C	10.1021/jm3003679
	CHEMBL2164335	81783	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C	10.1021/jm3003679
	145964390	164284	0	None	95	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212254	164284	0	None	95	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	162659287	181265	0	None	-85	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4762226	181265	0	None	-85	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	53245590	92370	43	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
	CHEMBL2431120	92370	43	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
	145976946	163910	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207568	163910	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	155538350	172356	0	None	-20	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	466	9	1	8	2.0	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4476370	172356	0	None	-20	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	466	9	1	8	2.0	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	164611003	185320	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4860006	185320	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	56850796	71503	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926686	71503	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962913	71503	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	76332585	106374	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121441	106374	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139446	106374	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
	11674602	68385	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	344	7	1	3	2.8	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917335	68385	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	344	7	1	3	2.8	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	145947627	167667	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4163626	167667	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302240	167667	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	90644076	112054	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	406	7	1	7	2.4	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289975	112054	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	406	7	1	7	2.4	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	134131147	142206	0	None	-5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884584	142206	0	None	-5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	168282733	191035	0	None	-79	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	386	9	3	9	1.4	COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5187317	191035	0	None	-79	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	386	9	3	9	1.4	COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	164628531	186440	0	None	-131	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4876727	186440	0	None	-131	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	122483229	138077	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764477	138077	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765850	138077	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	90654684	110078	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	502	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235756	110078	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	502	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	90654831	109799	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233401	109799	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	137635884	155876	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	427	7	2	3	4.1	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4060649	155876	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	427	7	2	3	4.1	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL5087742	215093	0	None	-22	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2csc3ccccc23)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	90656702	112582	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262433	112582	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302235	112582	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	4713248	207884	3	None	2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	281	5	2	3	1.2	CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm030030n
	CHEMBL96729	207884	3	None	2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	281	5	2	3	1.2	CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm030030n
	155531846	171621	0	None	-18	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	300	4	1	7	0.8	CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4465929	171621	0	None	-18	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	300	4	1	7	0.8	CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	162676589	183766	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4800511	183766	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804122	183766	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	164613772	188466	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4859722	188466	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL5028215	188466	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	122483229	138077	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764477	138077	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765850	138077	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	45028192	62557	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	416	5	0	6	4.6	O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782801	62557	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	416	5	0	6	4.6	O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12	10.1021/jm2000773
	7125890	117912	12	None	-6	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	408	4	1	4	5.8	Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403341	117912	12	None	-6	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	408	4	1	4	5.8	Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1	10.1016/j.bmcl.2015.03.049
	164613772	188466	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4859722	188466	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL5028215	188466	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	155562652	175137	0	None	-15	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	552	9	1	7	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	CHEMBL4570209	175137	0	None	-15	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	552	9	1	7	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	60196076	81789	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL2164342	81789	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	44408805	76709	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.8	O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL206667	76709	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.8	O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1	10.1016/j.bmcl.2005.11.067
	54758203	65964	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	CHEMBL1836783	65964	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	118626140	165894	0	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4250244	165894	0	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	71456779	81381	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	3.7	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159454	81381	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	3.7	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	156017999	177795	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	302	2	0	2	4.3	CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL4643725	177795	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	302	2	0	2	4.3	CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1	10.1016/j.bmc.2019.115262
	164628882	186426	0	None	-48	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	477	6	0	6	3.4	COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4876545	186426	0	None	-48	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	477	6	0	6	3.4	COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1	10.1016/j.bmcl.2021.128028
	56649650	67829	0	None	-112	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910141	67829	0	None	-112	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	13091359	113512	0	None	-138	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321790	113512	0	None	-138	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	44455973	97440	7	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	1	2	3	2.3	CCC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL270176	97440	7	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	1	2	3	2.3	CCC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	10960943	204237	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	428	7	1	3	5.4	CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	CHEMBL71165	204237	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	428	7	1	3	5.4	CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	11488153	85111	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL224935	85111	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	198967	91745	57	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	248	1	2	1	3.4	c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	CHEMBL241083	91745	57	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	248	1	2	1	3.4	c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	CHEMBL5285633	194282	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	450	7	0	5	4.2	O=C1CC2CCCc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2023.117256
	44424655	143265	0	None	-1	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL389700	143265	0	None	-1	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	60167309	75268	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037432	75268	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.ejmech.2012.03.042
	60167309	75268	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL2037432	75268	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	168295839	192221	0	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	370	9	3	8	1.8	Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5205324	192221	0	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	370	9	3	8	1.8	Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	156010295	177111	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	306	3	0	2	4.3	CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633889	177111	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	306	3	0	2	4.3	CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3	10.1016/j.bmc.2020.115578
	155515324	169931	0	None	-27	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	382	4	1	8	0.8	CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4441655	169931	0	None	-27	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	382	4	1	8	0.8	CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	155519393	170395	0	None	-97	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	397	7	2	4	5.3	COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4448285	170395	0	None	-97	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	397	7	2	4	5.3	COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	156019370	177933	0	None	-25	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	422	9	1	5	4.4	O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	CHEMBL4645793	177933	0	None	-25	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	422	9	1	5	4.4	O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	134131159	142222	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	10	0	5	4.5	c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	CHEMBL3884743	142222	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	10	0	5	4.5	c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	57397411	68401	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917351	68401	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL5265814	193430	0	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysisDisplacement of [3H]SB269970 from human 5-HT7 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis	ChEMBL	436	7	0	5	3.8	O=C1CC2CCc3ccsc3C2=NN1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2023.117256
	1621	2413	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	3233	3486	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	3247	3486	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	6604889	3486	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	CHEMBL282199	3486	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	DB13988	3486	44	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	284	2894	69	None	457	2	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
	5283387	2894	69	None	457	2	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
	CHEMBL15927	2894	69	None	457	2	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
	2389	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	2389	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	5073	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	5073	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	96	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	96	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	CHEMBL85	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	CHEMBL85	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	DB00734	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	DB00734	3306	118	None	-7	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	1809	134	32	3H-MESULERGINE	-2	37	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-MESULERGINE	-2	37	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-MESULERGINE	-2	37	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	3H-MESULERGINE	2	37	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-MESULERGINE	2	37	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-MESULERGINE	2	37	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	72	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1809	134	32	3H-5HT	-7	37	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	3H-5HT	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	UNDEFINED	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-7	37	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	UNDEFINED	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-7	37	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	UNDEFINED	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	23643664	2335	8	UNDEFINED	-1	5	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	8434	2335	8	UNDEFINED	-1	5	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	CHEMBL243954	2335	8	UNDEFINED	-1	5	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	5	139	72	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1809	134	32	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	3H-5CT	2	37	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5CT	2	37	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5CT	2	37	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	72	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	121	3H-MESULERGINE	1	31	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-MESULERGINE	1	31	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-MESULERGINE	1	31	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1809	134	32	125I-LSD	-2	37	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	125I-LSD	-2	37	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	125I-LSD	-2	37	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4106	2485	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	1238	203151	24	3H-LSD	1	17	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	203151	24	3H-LSD	1	17	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1809	134	32	3H-5HT	2	37	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	2	37	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	2	37	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1621	2413	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2389	3306	118	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3306	118	3H-5-CT	-8	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-5-CT	-8	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-5-CT	-8	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-5-CT	-8	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-5-CT	-8	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1809	134	32	125I-LSD	-2	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	125I-LSD	-2	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	125I-LSD	-2	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	UNDEFINED	-2	37	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	UNDEFINED	-2	37	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	UNDEFINED	-2	37	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	16362	3103	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	16362	3103	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	107	141	121	3H-5CT	1	31	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5CT	1	31	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5CT	1	31	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1588	2311	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	125I-LSD	-6	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	107	141	121	3H-5HT	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	25107716	2336	43	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	8436	2336	43	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	CHEMBL522691	2336	43	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	5	139	72	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	121	3H-MESULERGINE	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-MESULERGINE	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-MESULERGINE	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	101	3793	24	3H-LSD	-2	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	55752	3793	24	3H-LSD	-2	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL35057	3793	24	3H-LSD	-2	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	4106	2485	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	46780481	107504	20	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	1809	134	32	3H-5CT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5CT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5CT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	25107518	187260	0	UNDEFINED	20	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	None
	CHEMBL492871	187260	0	UNDEFINED	20	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	None
	1809	134	32	125I-LSD	-2	37	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	125I-LSD	-2	37	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	125I-LSD	-2	37	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1588	2311	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-5HT	-6	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1809	134	32	3H-5HT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	23643870	92835	0	UNDEFINED	35	3	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243955	92835	0	UNDEFINED	35	3	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	46780481	107504	20	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	1809	134	32	3H-5HT	-7	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-7	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-7	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	107	141	121	UNDEFINED	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	UNDEFINED	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	UNDEFINED	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	2389	3306	118	3H-LSD	-7	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-7	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-7	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-7	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-7	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	107	141	121	3H-5HT	-3	31	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	107	141	121	3H-5HT	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-3	31	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-3	31	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1809	134	32	3H-5CT	2	37	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5CT	2	37	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5CT	2	37	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	25107520	187569	0	UNDEFINED	70	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	None
	CHEMBL494709	187569	0	UNDEFINED	70	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	None
	1809	134	32	3H-5HT	-12	37	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-12	37	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-12	37	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	72	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	121	3H-5HT	1	31	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	1	31	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	1	31	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	4106	2485	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2105	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2105	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	4106	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	4106	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	23643663	92815	0	UNDEFINED	13	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243744	92815	0	UNDEFINED	13	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	1809	134	32	3H-5HT	-2	37	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-2	37	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-2	37	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	32	3H-5HT	-12	37	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-12	37	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-12	37	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	115237	55555	119	3H-5HT	-5	55	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-5HT	-5	55	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	1238	203151	24	3H-LSD	1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	203151	24	3H-LSD	1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	5	139	72	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2389	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-7	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	121	3H-5CT	1	31	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5CT	1	31	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5CT	1	31	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	133	2479	52	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2389	3306	118	3H-5HT	-4	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-5HT	-4	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-5HT	-4	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-5HT	-4	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-5HT	-4	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	107	141	121	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	107	141	121	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	103	4122	61	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	242	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	206	2476	16	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	133	2479	52	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	4106	2485	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2470	3626	50	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	103	4122	61	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	242	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	469	124	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	31101	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	31101	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	None	216026	0	3H-5CT	-67	8	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	135	2515	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2515	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135398745	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2470	3626	50	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2543	3681	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	100	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	681	1453	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	681	1453	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1209	1645	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1209	1645	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1204	1919	119	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1204	1919	119	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1919	119	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1919	119	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1919	119	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1919	119	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1919	119	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1919	119	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1919	119	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1919	119	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1919	119	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1919	119	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	12575	1975	30	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	12575	1975	30	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	54459	1975	30	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	54459	1975	30	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	CHEMBL10316	1975	30	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	CHEMBL10316	1975	30	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	1427	2000	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1427	2000	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1357	2468	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2468	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2468	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2468	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2468	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2468	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2468	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2468	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2468	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2468	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2468	139	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2468	139	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	484	2837	51	3H-5HT	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	484	2837	51	3H-LSD	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-5HT	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-LSD	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-5HT	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-LSD	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	102484	2886	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	102484	2886	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	2149	2886	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	2149	2886	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	3396	2886	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	3396	2886	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	4581	2886	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	4581	2886	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	CHEMBL53929	2886	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	CHEMBL53929	2886	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	DB13251	2886	50	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	DB13251	2886	50	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	2176	3104	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2176	3104	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	173	3238	95	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	173	3238	95	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	189	3466	39	3H-5CT	-416	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3466	39	3H-5CT	-416	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3466	39	3H-5CT	-416	17	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	130	3474	47	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3378093	3474	47	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL281350	3474	47	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	108182	4100	22	3H-5HT	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	108182	4100	22	3H-LSD	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4100	22	3H-5HT	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4100	22	3H-LSD	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4100	22	3H-5HT	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4100	22	3H-LSD	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	671690	27066	35	3H-5HT	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	671690	27066	35	3H-LSD	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	CHEMBL1365455	27066	35	3H-5HT	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	CHEMBL1365455	27066	35	3H-LSD	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	4595	176691	106	3H-5HT	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	4595	176691	106	3H-LSD	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176691	106	3H-5HT	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176691	106	3H-LSD	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	2771	194994	74	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	2771	194994	74	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	194994	74	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	194994	74	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	194994	74	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	194994	74	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	54841	203104	52	3H-5HT	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	CHEMBL641	203104	52	3H-5HT	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	2995	204382	53	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	2995	204382	53	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	2995	204382	53	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	3337	206344	27	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	3337	206344	27	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	None	215946	0	125I-LSD	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	None	215946	0	3H-5HT	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	None	215946	0	3H-LSD	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	86287410	215947	0	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	312	2	1	4	2.3	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	86287410	215947	0	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	312	2	1	4	2.3	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	None	215948	0	3H-5HT	-4	2	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	336	1	2	4	1.9	CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl	None
	None	215948	0	3H-LSD	-4	2	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	336	1	2	4	1.9	CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl	None
	None	215951	0	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	2	1	4	1.9	CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	None	215951	0	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	2	1	4	1.9	CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	3035240	215953	0	3H-5HT	-11	5	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	359	3	2	4	2.6	COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl	None
	3035240	215953	0	3H-LSD	-11	5	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	359	3	2	4	2.6	COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl	None
	None	215986	0	3H-5HT	-43	6	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	367	2	1	6	2.4	CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl	None
	None	215986	0	3H-LSD	-43	6	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	367	2	1	6	2.4	CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl	None
	1576	216300	0	3H-LSD	-1	41	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
	None	216423	0	Functional	-66	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	216423	0	UNDEFINED	-66	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	3075702	217305	0	3H-LSD	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
	1028	289	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	139148732	289	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	479	289	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	5816	289	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	CHEMBL679	289	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	DB00668	289	71	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	135398737	955	93	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	132	1264	13	3H-5HT	-281838	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
	155346	1264	13	3H-5HT	-281838	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
	CHEMBL378501	1264	13	3H-5HT	-281838	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
	681	1453	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	681	1453	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	107780	1831	54	3H-LSD	-2691	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	14	1831	54	3H-LSD	-2691	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL15928	1831	54	3H-LSD	-2691	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	1204	1919	119	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1204	1919	119	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1919	119	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1919	119	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1919	119	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1919	119	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1919	119	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1919	119	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1919	119	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1919	119	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1919	119	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1919	119	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1782	2501	84	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	241	2501	84	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	4168	2501	84	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	CHEMBL86	2501	84	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	DB01233	2501	84	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	135	2515	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	484	2837	51	3H-5HT	-100	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	3H-5HT	-100	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	3H-5HT	-100	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	2176	3104	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2176	3104	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	127	3105	52	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
	688095	3105	52	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL117405	3105	52	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
	2274	3151	58	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	243	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3052762	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3502	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	CHEMBL117287	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	DB06480	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	128563	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	28	3470	46	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3292447	3470	46	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL20963	3470	46	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	6917970	3665	61	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3665	61	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3665	61	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	214	3831	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	108182	4100	22	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4100	22	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4100	22	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	2662	11352	131	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11352	131	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	5090	15529	106	3H-LSD	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	15529	106	3H-LSD	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	10297	27081	30	3H-LSD	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	CHEMBL136560	27081	30	3H-LSD	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	156391	46770	99	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46770	99	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46770	99	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	2244	94204	100	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	94204	100	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	3663	99939	83	3H-LSD	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	CHEMBL286494	99939	83	3H-LSD	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	446220	133496	14	3H-LSD	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	CHEMBL370805	133496	14	3H-LSD	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	1615	167767	24	3H-LSD	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167767	24	3H-LSD	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	5280343	188251	124	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	188251	124	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	188251	124	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	3672	192509	136	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	CHEMBL521	192509	136	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	4495	196512	92	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	196512	92	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	54677470	200528	115	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	200528	115	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	200528	115	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	162265	202251	22	3H-LSD	-16	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	202251	22	3H-LSD	-16	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	202251	22	3H-LSD	-16	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	5281600	203002	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	203002	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	203043	87	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203043	87	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	1973	203460	15	3H-LSD	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL1394464	203460	15	3H-LSD	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL66089	203460	15	3H-LSD	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	3821	204695	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
	CHEMBL742	204695	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
	4158	205318	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	205318	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	205318	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	205478	72	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	205478	72	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	205478	72	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	119607	206180	113	3H-LSD	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	CHEMBL865	206180	113	3H-LSD	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	3337	206344	27	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	57174031	215917	0	3H-5HT	-1778	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
	None	215968	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
	104911	215994	0	3H-LSD	-41686	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	25137849	216153	0	3H-LSD	-1	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	216153	0	3H-LSD	-1	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	None	216188	0	3H-5-CABOXAMIDOTRYPTAMINE	-933	15	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
	None	216285	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
	None	216286	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
	None	216287	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
	None	216288	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
	None	216289	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
	None	216290	0	3H-LSD	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
	None	216291	0	3H-LSD	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
	None	216292	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
	None	216301	0	3H-LSD	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
	4978	216302	0	3H-LSD	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
	None	216303	0	3H-LSD	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
	None	216304	0	3H-LSD	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
	None	216305	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
	135269	216363	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	216364	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	216365	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	84003	216366	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	123619	216367	0	3H-LSD	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	119828	216368	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	None	216369	0	3H-LSD	-7	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	216462	0	3H-LSD	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	11957566	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	1219	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	3296	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	950	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	CHEMBL285755	184	25	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	135398745	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2515	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2470	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	265	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	89576	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	CHEMBL1288652	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	179	399	115	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2470	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1353	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	3294	1993	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	135	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1353	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	119570	3137	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	103	4122	61	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	11954259	215954	0	3H-LSD	-39	44	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	134	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2497	24	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	206	2476	16	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	134	2497	24	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	21830793	91806	10	3H-8-OH-DPAT	-85	46	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	CHEMBL2413154	91806	10	3H-8-OH-DPAT	-85	46	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	135398745	2893	112	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	180	400	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	125I-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	277	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	277	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1346	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	280	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	9899402	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	CHEMBL9666	83	117	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	180	400	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	3H-LSD	-125	40	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	31101	726	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	277	1289	62	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	3652	4066	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	1574	81	60	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	2398	951	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	951	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	951	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	951	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	951	62	3H-5HT	-15	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	11954224	215928	0	3H- LSD	-18197	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	11954224	215928	0	3H-LSD	-18197	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	134	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	135398737	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	122	1425	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	156314	1425	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL1332062	1425	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	134	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	135398737	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	24768524	93173	0	UNDEFINED	-4	3	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	None
	CHEMBL244577	93173	0	UNDEFINED	-4	3	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	None
	1613	2333	53	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	2337	3232	77	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	1524	2168	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-501	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1220	187	55	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	179	399	115	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	11954224	215928	0	3H-5CT	-1174	60	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	242	469	124	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	135409468	2022	69	3H-LSD	-5	40	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2022	69	3H-LSD	-5	40	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2022	69	3H-LSD	-5	40	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	191	402	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	214	3831	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	135398737	955	93	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1150	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	25107581	192607	0	UNDEFINED	-14	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	CHEMBL521687	192607	0	UNDEFINED	-14	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	1150	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	5074	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	11954259	215954	0	3H-LSD	-51	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	5074	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-36	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	206	2476	16	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	None	215920	0	3H-5CT	-17	11	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	11954259	215954	0	3H-LSD	-51	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	2181	3106	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3106	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3106	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3106	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3106	46	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	None	215915	0	3H-5HT	-2511	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	None	215915	0	UNDEFINED	-2511	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	2402	3345	62	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3345	62	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3345	62	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3345	62	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3345	62	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	135398745	2893	112	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	133	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1150	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1150	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	7153	97992	77	3H-LSD	-8	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-LSD	-8	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	2337	3232	77	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	134	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	11954224	215928	0	125I-LSD	-245	60	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	134	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	11954224	215928	0	125I-LSD	-245	60	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	2105	3032	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	135398737	955	93	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1613	2333	53	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	None	216353	0	3H-LSD	-199	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
	2337	3232	77	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	213	3824	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	11675876	187490	0	UNDEFINED	-54	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	CHEMBL494316	187490	0	UNDEFINED	-54	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	135398737	955	93	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2476	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	1342	36	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	206	2476	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	283	3108	57	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3108	57	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3108	57	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	1342	36	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1588	2311	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-5CT	-21	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2337	3232	77	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398745	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	191	402	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1150	3849	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	135398737	955	93	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	10257	735	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	144	735	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	CHEMBL416526	735	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	DB01445	735	31	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	2726	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	5074	3307	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2470	3626	50	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5074	3307	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5CT	-61	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	6852400	215914	0	3H-5CT	-1023	22	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-5CT	-1023	22	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	12016890	190752	6	3H-5HT	-3235	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
	CHEMBL5183389	190752	6	3H-5HT	-3235	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
	2274	3151	58	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	1621	2413	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1524	2168	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1220	187	55	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	133	2479	52	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2479	52	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	17676	7040	29	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	None
	5281082	7040	29	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	None
	CHEMBL1085	7040	29	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	None
	1238	203151	24	3H-5CT	-13	17	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	203151	24	3H-5CT	-13	17	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	115237	55555	119	3H-LSD	-20	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-LSD	-20	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	2389	3306	118	3H-LSD	-8	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-8	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-8	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-8	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-8	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	10090005	215961	0	3H-LSD	-3	11	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
	1588	2311	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-5CT	-21	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2105	3032	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2470	3626	50	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	145	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	206	2476	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	145	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	25137849	216153	0	3H-LSD	-1	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	216153	0	3H-LSD	-1	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	1524	2168	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	125I-LSD	-169	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	135398745	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2726	916	68	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2726	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	135398737	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2476	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	10257	735	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	144	735	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	CHEMBL416526	735	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	DB01445	735	31	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	3294	1993	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	5074	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5074	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	125I-LSD	-36	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2470	3626	50	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	25107650	187261	0	UNDEFINED	-23	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	CHEMBL492872	187261	0	UNDEFINED	-23	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	62865	1263	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1263	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1263	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1263	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1263	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	163839	2934	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	268	2934	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	CHEMBL55171	2934	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	25107649	187233	0	UNDEFINED	-1	3	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	CHEMBL492691	187233	0	UNDEFINED	-1	3	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	134	2497	24	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	209	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	25107519	187645	0	UNDEFINED	-17	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	CHEMBL495120	187645	0	UNDEFINED	-17	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	202	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	209	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	209	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	25137849	216153	0	3H-LSD	-1	41	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	216153	0	3H-LSD	-1	41	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	115	3762	80	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	1353	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1346	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	280	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	9899402	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	CHEMBL9666	83	117	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	135398745	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	5	139	72	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	206	2476	16	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	209	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	5074	3307	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-MESULERGINE	-36	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2543	3681	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	24768520	92978	0	UNDEFINED	-1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL244161	92978	0	UNDEFINED	-1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	135398745	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2176	3104	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2543	3681	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1220	187	55	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	2543	3681	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1220	187	55	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7153	97992	77	UNDEFINED	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	UNDEFINED	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	7153	97992	77	3H-5HT	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	265	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	89576	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	CHEMBL1288652	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	1353	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1524	2168	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-169	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1816	2523	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2523	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2523	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2523	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2523	102	3H-5HT	-165	18	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	1830	2572	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	2726	916	68	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	216299	0	3H-LSD	-3	41	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
	15897	2840	0	3H-LSD	-12	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-LSD	-12	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-LSD	-12	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	24768525	143896	0	UNDEFINED	-7	3	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	None
	CHEMBL390213	143896	0	UNDEFINED	-7	3	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	None
	2435	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	2435	3563	83	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	2435	3563	83	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	16106	118120	34	3H-LSD	-3	12	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
	CHEMBL340801	118120	34	3H-LSD	-3	12	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
	2435	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	24768518	92810	0	UNDEFINED	-46	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243743	92810	0	UNDEFINED	-46	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	102	4096	48	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	214	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1524	2168	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5CT	-1023	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2337	3232	77	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	214	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	25107717	187526	1	UNDEFINED	-6	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	CHEMBL494512	187526	1	UNDEFINED	-6	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	2389	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	4106	2485	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2389	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-8	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	4106	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	4106	2485	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	4106	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	None	216252	0	3H-LSD	-42	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
	25107648	187199	0	UNDEFINED	25	3	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	None
	CHEMBL492480	187199	0	UNDEFINED	25	3	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	None
	145	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	134	2497	24	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2435	3563	83	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	None	215920	0	3H-5CT	-17	11	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1577	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	1830	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	173	3238	95	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1830	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	2337	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	25107517	187232	0	UNDEFINED	-1	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	CHEMBL492690	187232	0	UNDEFINED	-1	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	37459	743	13	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	206	2476	16	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	133	2479	52	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	282	1407	0	3H-5HT	-3548	7	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	522609	1407	0	3H-5HT	-3548	7	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	135398745	2893	112	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	None	216423	0	3H-5CT	-208	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	216423	0	UNDEFINED	-208	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	5074	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1238	203151	24	3H-5CT	-13	17	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	203151	24	3H-5CT	-13	17	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1150	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	25107515	187336	0	UNDEFINED	-16	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	CHEMBL493305	187336	0	UNDEFINED	-16	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	1353	1898	93	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	5074	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	125I-LSD	-36	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1150	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1342	36	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1342	36	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	277	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1353	1898	93	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	24768522	142551	0	UNDEFINED	2	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL389110	142551	0	UNDEFINED	2	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	277	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1220	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	25107651	187686	0	UNDEFINED	-4	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	CHEMBL495321	187686	0	UNDEFINED	-4	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	1220	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	179	399	115	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	166535	215945	0	3H-5HT	-87	2	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	413	6	1	4	3.4	C1CN(CCC12C(=O)NCN2C3=CC=C(C=C3)F)CCCC(=O)C4=CC=C(C=C4)F	None
	1220	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	2726	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2726	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	7153	97992	77	125I-LSD	-14	34	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	125I-LSD	-14	34	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	135	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	54477	84624	36	3H-LSD	-501	23	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	CHEMBL22242	84624	36	3H-LSD	-501	23	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	135398745	2893	112	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2477	742	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1353	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	242	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	1353	1898	93	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2477	742	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	25107652	187388	0	UNDEFINED	-20	3	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	CHEMBL493709	187388	0	UNDEFINED	-20	3	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	242	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	135398737	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	191	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	135398737	955	93	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1613	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	134	2497	24	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2497	24	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2389	3306	118	3H-5HT	-8	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-5HT	-8	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-5HT	-8	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-5HT	-8	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-5HT	-8	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	16351	102703	47	3H-LSD	-1	6	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL304902	102703	47	3H-LSD	-1	6	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	279	1648	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	49381	1648	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	CHEMBL63756	1648	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	2865	4112	73	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	2105	3032	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	5	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2865	4112	73	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	135398737	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	191	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1220	187	55	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1353	1898	93	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2601	3751	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	15897	2840	0	3H-LSD	-12	37	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-LSD	-12	37	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-LSD	-12	37	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	3337	206344	27	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	25108474	193176	0	UNDEFINED	-38	3	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	CHEMBL523381	193176	0	UNDEFINED	-38	3	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	135398737	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	24768523	143655	0	UNDEFINED	-4	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL390015	143655	0	UNDEFINED	-4	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	1613	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	242	469	124	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5074	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5074	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-69	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	4106	2485	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5074	3307	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5CT	-61	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1220	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	135398737	955	93	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2470	3626	50	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398737	955	93	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	31101	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	31101	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	133	2479	52	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	11954224	215928	0	3H-5CT	-1174	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	18971832	2402	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	21	2402	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	CHEMBL3186179	2402	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	24768517	92799	0	UNDEFINED	2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243742	92799	0	UNDEFINED	2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	5	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	121	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	2865	4112	73	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	5	139	72	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	121	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	11976	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	2389	3306	118	3H-5CT	-8	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3306	118	3H-MESULERGINE	-7	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-5CT	-8	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-MESULERGINE	-7	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-5CT	-8	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-MESULERGINE	-7	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-5CT	-8	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-MESULERGINE	-7	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-5CT	-8	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-MESULERGINE	-7	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5074	3307	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-MESULERGINE	-61	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	25107578	193032	0	UNDEFINED	4	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	CHEMBL522343	193032	0	UNDEFINED	4	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	216239	23763	118	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1200485	23763	118	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1336	23763	118	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	66265	93984	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL248702	93984	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	2726	916	68	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	122	1425	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	156314	1425	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL1332062	1425	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4223	3961	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3961	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3961	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3961	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3961	94	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	102	4096	48	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	11976	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	11976	917	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	25107718	187514	0	UNDEFINED	18	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	None
	CHEMBL494458	187514	0	UNDEFINED	18	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	None
	240	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2402	3345	62	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3345	62	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3345	62	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3345	62	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3345	62	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	103	4122	61	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	1220	187	55	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	11954224	215928	0	3H-5HT	-269	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	6450478	215987	0	3H-LSD	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
	1353	1898	93	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3033769	3256	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	3299	3256	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	94	3256	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	CHEMBL8809	3256	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	DB12518	3256	61	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	1577	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	54477	84624	36	3H-LSD	-69	23	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	CHEMBL22242	84624	36	3H-LSD	-69	23	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	53389	98419	23	3H-LSD	-1	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
	CHEMBL275707	98419	23	3H-LSD	-1	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
	33630	178933	99	3H-LSD	-891	28	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL47050	178933	99	3H-LSD	-891	28	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	None	215962	0	3H-LSD	-1	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	342	1	1	5	1.8	CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl	None
	None	215963	0	3H-LSD	-1	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	334	4	0	3	4.9	C[N+](C)(CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)[O-]	None
	277	1289	62	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2176	3104	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2726	916	68	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1577	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3677	110	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2543	3681	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2543	3681	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1220	187	55	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	187	55	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	187	55	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	283	3108	57	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3108	57	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3108	57	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	None	216026	0	3H-5CT	-67	8	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1220	187	55	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1342	36	49	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	115	3762	80	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	24768519	92834	0	UNDEFINED	1	3	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243953	92834	0	UNDEFINED	1	3	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	25108475	187461	0	UNDEFINED	-2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	CHEMBL494119	187461	0	UNDEFINED	-2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	681	1453	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1453	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1453	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1453	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1453	72	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	484	2837	51	125I-LSD	-7	36	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2837	51	125I-LSD	-7	36	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2837	51	125I-LSD	-7	36	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	2176	3104	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2543	3681	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	108182	4100	22	125I-LSD	-2	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4100	22	125I-LSD	-2	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4100	22	125I-LSD	-2	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	73333	5931	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL1079935	5931	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	73333	5931	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL1079935	5931	31	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	135	2515	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2543	3681	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	15387	45792	55	3H-LSD	-85	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45792	55	3H-LSD	-85	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	15387	45792	55	3H-LSD	-85	24	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45792	55	3H-LSD	-85	24	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	10624	70271	19	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	70271	19	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	70271	19	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	2543	3681	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5	139	72	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2865	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	25107516	187161	0	UNDEFINED	-4	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	CHEMBL492282	187161	0	UNDEFINED	-4	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	133	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	191	402	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1353	1898	93	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	107	141	121	3H-5HT	-9	31	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-9	31	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-9	31	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	135398737	955	93	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1588	2311	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1588	2311	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-5HT	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	UNDEFINED	-6	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	4106	2485	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5	139	72	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	206	2476	16	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	180	400	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	180	400	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	None	-12	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	None	-99	40	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2477	742	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	2477	742	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1524	2168	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	None	-38	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	133	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1353	1898	93	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	133	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1524	2168	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	None	-501	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	114948	60267	14	None	1	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	CHEMBL1743263	60267	14	None	1	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	2337	3232	77	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	214	3831	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1830	2572	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	1353	1898	93	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1816	2523	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2523	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2523	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2523	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2523	102	None	-165	18	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	2543	3681	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1621	2413	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2389	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	6971132	215984	0	3H-LSD	-1	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
	2865	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	2865	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	1524	2168	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	None	-169	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	4806	3977	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	7351	3977	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	9966051	3977	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	CHEMBL2104993	3977	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	DB09068	3977	88	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	228	444	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	444	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	444	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	444	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	444	28	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	10531	1408	21	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1408	21	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1408	21	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1408	21	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1408	21	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	1588	2311	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-LSD	-19	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2895	203569	41	None	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	CHEMBL669	203569	41	None	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	277	1289	62	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	3652	4066	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	133	2479	52	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2389	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-8	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	11154555	797	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5037	797	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	7671	797	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL2028019	797	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL3085826	797	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB06016	797	62	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2470	3626	50	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398745	2893	112	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135409468	2022	69	3H-LSD	-21	40	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2022	69	3H-LSD	-21	40	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2022	69	3H-LSD	-21	40	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	135398737	955	93	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	133	2479	52	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2470	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5567	42772	27	3H-LSD	-69	8	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
	CHEMBL15023	42772	27	3H-LSD	-69	8	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
	133	2479	52	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2470	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398737	955	93	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	107780	1831	54	3H-5CT	-2691	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	14	1831	54	3H-5CT	-2691	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL15928	1831	54	3H-5CT	-2691	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	1524	2168	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5CT	-1023	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1150	3849	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	None	216213	0	3H-LSD	-64565	30	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	135398737	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2476	16	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	135398737	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135	2515	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2515	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2515	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2274	3151	58	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	180	400	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	None	-125	40	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	135	2515	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135398745	2893	112	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	114948	60267	14	None	-1	3	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	CHEMBL1743263	60267	14	None	-1	3	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	135	2515	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	206	2476	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	129211	3722	78	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	2562	3722	78	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	488	3722	78	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	CHEMBL836	3722	78	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	DB00706	3722	78	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	24768516	92557	0	UNDEFINED	11	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243523	92557	0	UNDEFINED	11	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	206	2476	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	100	3776	58	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	135	2515	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2470	3626	50	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	62865	1263	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1263	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1263	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1263	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1263	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	100	3776	58	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	277	1289	62	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	11954224	215928	0	None	-269	60	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1613	2333	53	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	191	402	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	135398737	955	93	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2726	916	68	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	49831411	217718	0	None	-1	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
	133	2479	52	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2435	3563	83	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	2220	3112	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	27400	3112	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	93	3112	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	CHEMBL294951	3112	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	DB06153	3112	82	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	209	3035	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	209	3035	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	3294	1993	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	2726	916	68	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	242	469	124	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	3294	1993	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	4806	3977	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	7351	3977	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	9966051	3977	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	CHEMBL2104993	3977	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	DB09068	3977	88	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	135398737	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	242	469	124	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	134	2497	24	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	49831411	217718	0	None	-1	15	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
	3294	1993	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	212	3777	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	2639	3777	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	941651	3777	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	CHEMBL1201	3777	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	DB01623	3777	47	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	134	2497	24	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2497	24	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1212	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1621	2413	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2601	3751	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2726	916	68	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	100	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2726	916	68	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	162265	202251	22	3H-LSD	-16	45	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	202251	22	3H-LSD	-16	45	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	202251	22	3H-LSD	-16	45	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	None	216213	0	3H-LSD	-64565	30	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	25107583	192853	0	UNDEFINED	-2	3	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	CHEMBL522194	192853	0	UNDEFINED	-2	3	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	1712	2475	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2475	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2475	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2475	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2475	43	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	1712	2475	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2475	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2475	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2475	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2475	43	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	3337	206344	27	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	1524	2168	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2168	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-501	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-169	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	25107582	187560	0	UNDEFINED	-9	3	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	CHEMBL494661	187560	0	UNDEFINED	-9	3	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	277	1289	62	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	135398737	955	93	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1289	62	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	None	215946	0	125I-LSD	-616	15	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	None	215946	0	125I-LSD	-616	15	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	1524	2168	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5CT	-501	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2470	3626	50	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	31101	726	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	10531	1408	21	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1408	21	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1408	21	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1408	21	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1408	21	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	1212	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1649	50	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1649	50	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3389	217683	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
	5	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	133	2479	52	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	135398737	955	93	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	133	2479	52	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	11976	917	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	145	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2865	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	25107647	187460	0	UNDEFINED	11	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	None
	CHEMBL494118	187460	0	UNDEFINED	11	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	None
	145	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	103	4122	61	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	11978813	718	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	5014	718	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	7672	718	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	CHEMBL2105760	718	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	DB09128	718	79	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	2389	3306	118	None	-8	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	None	-8	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	None	-8	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	None	-8	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	None	-8	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	115237	55555	119	None	-20	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	None	-20	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	25107580	187489	0	UNDEFINED	2	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	CHEMBL494312	187489	0	UNDEFINED	2	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	439280	119993	107	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	6971044	119993	107	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	CHEMBL350221	119993	107	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	1621	2413	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	103	4122	61	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2389	3306	118	None	-7	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	None	-7	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	None	-7	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	None	-7	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	None	-7	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	214	3831	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	135	2515	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	24768526	93202	0	UNDEFINED	-41	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	None
	CHEMBL244792	93202	0	UNDEFINED	-41	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	None
	4452	2742	19	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	983	2742	19	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	CHEMBL20734	2742	19	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	24768521	92983	0	UNDEFINED	-19	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL244162	92983	0	UNDEFINED	-19	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	1342	36	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	134	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1342	36	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	134	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2477	742	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1613	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	1613	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	141	1415	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1415	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1415	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1415	35	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6852400	215914	0	3H-5CT	-1023	22	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-5CT	-1023	22	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	1613	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	37459	743	13	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	2105	3032	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	25107579	187418	0	UNDEFINED	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	CHEMBL493909	187418	0	UNDEFINED	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	None	215915	0	3H-5HT	-151	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	None	215915	0	3H-5HT	-151	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	16362	3103	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	1588	2311	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	None	-6	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	213046	2370	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	4168	2370	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	7461	2370	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	CHEMBL1237021	2370	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	DB08815	2370	59	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	16362	3103	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3103	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3103	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3103	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3103	71	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	206	2476	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	2865	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	206	2476	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	2865	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	46780481	107504	20	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	1621	2413	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	103	4122	61	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	215920	0	3H-5HT	-7	11	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1621	2413	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	242	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2470	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	6852400	215914	0	3H-5HT	-223	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-5HT	-223	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	180	400	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	3H-5HT	-125	40	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	134	2497	24	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1353	1898	93	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	10257	735	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	144	735	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	CHEMBL416526	735	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	DB01445	735	31	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	2543	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2543	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	100	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	4806	3977	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	7351	3977	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	9966051	3977	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	CHEMBL2104993	3977	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	DB09068	3977	88	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	281	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
	5312148	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
	CHEMBL12264	3484	28	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
	242	469	124	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	34	469	124	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	60795	469	124	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	CHEMBL1112	469	124	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	DB01238	469	124	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	11959	1524	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	405	5	1	7	3.0	Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl	22824189
	9909267	1524	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	405	5	1	7	3.0	Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl	22824189
	11151899	2124	13	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
	8432	2124	13	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
	CHEMBL4205783	2124	13	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
	24825775	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
	3929	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
	CHEMBL4205349	1511	14	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
	8431	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
	9843179	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
	CHEMBL69257	1472	9	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
	10028436	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
	3237	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
	CHEMBL95104	3506	5	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
	3233	3486	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	3247	3486	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	6604889	3486	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	CHEMBL282199	3486	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	DB13988	3486	44	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	5	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	5	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	5202	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	5202	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	CHEMBL39	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	CHEMBL39	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	DB08839	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	DB08839	139	72	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	23642275	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
	8433	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
	CHEMBL2164327	481	31	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
	25107716	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
	8436	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
	CHEMBL522691	2336	43	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
	16362	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	2172	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	90	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	CHEMBL1423	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	DB01100	3103	71	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	213046	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	4168	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	7461	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	CHEMBL1237021	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	DB08815	2370	59	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	11224758	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
	8435	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
	CHEMBL225284	2338	5	None	-4	6	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
	23643664	2335	8	None	1	5	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
	8434	2335	8	None	1	5	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
	CHEMBL243954	2335	8	None	1	5	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
	162265	202251	22	None	-16	45	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	202251	22	None	-16	45	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	202251	22	None	-16	45	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	3337	206344	27	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	202	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	213	3824	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	119570	3137	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	179	399	115	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2726	916	68	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	621	916	68	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	83	916	68	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	CHEMBL71	916	68	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	DB00477	916	68	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	18971832	2402	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	21	2402	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	CHEMBL3186179	2402	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	257	3467	13	None	-19952	4	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
	5311423	3467	13	None	-19952	4	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
	CHEMBL114112	3467	13	None	-19952	4	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
	29	789	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	9805719	789	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	CHEMBL2027925	789	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	102	4096	48	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	3659	4096	48	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	8969	4096	48	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	CHEMBL15245	4096	48	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	DB01392	4096	48	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	240	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	2769	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	44279790	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	660	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	CHEMBL1729	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	CHEMBL560739	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	DB00604	941	43	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	2543	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	2543	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	5358	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	5358	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	54	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	54	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	CHEMBL128	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	CHEMBL128	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	DB00669	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	DB00669	3681	68	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	1524	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	1524	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	1524	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	1524	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	197	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	197	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	197	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	197	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	3822	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	3822	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	3822	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	3822	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	88	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	88	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	88	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	88	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	CHEMBL51	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	CHEMBL51	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	CHEMBL51	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	CHEMBL51	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	DB12465	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	DB12465	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	DB12465	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	DB12465	2168	96	None	-501	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	1353	1898	93	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	3559	1898	93	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	86	1898	93	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	CHEMBL54	1898	93	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	DB00502	1898	93	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	115	3762	80	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
	4296	3762	80	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
	CHEMBL274866	3762	80	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
	2543	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	2543	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	5358	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	5358	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	54	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	54	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	CHEMBL128	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	CHEMBL128	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	DB00669	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	DB00669	3681	68	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	180	400	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	200	400	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	2160	400	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	CHEMBL629	400	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	DB00321	400	56	None	-99	40	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	2477	742	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	2477	742	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	36	742	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	36	742	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	437	742	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	437	742	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	CHEMBL49	742	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	CHEMBL49	742	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	DB00490	742	59	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	DB00490	742	59	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	1524	2168	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	197	2168	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	3822	2168	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	88	2168	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	CHEMBL51	2168	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	DB12465	2168	96	None	-38	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	1353	1898	93	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	1353	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	1353	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	1353	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	3559	1898	93	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	3559	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	3559	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	3559	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	86	1898	93	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	86	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	86	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	86	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	CHEMBL54	1898	93	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	CHEMBL54	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	CHEMBL54	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	CHEMBL54	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	DB00502	1898	93	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	DB00502	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	DB00502	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	DB00502	1898	93	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	115	3762	80	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
	4296	3762	80	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
	CHEMBL274866	3762	80	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
	1355	1998	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	142	1998	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	CHEMBL478	1998	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	DB12110	1998	88	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	282	1407	0	None	-3548	7	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8397408
	522609	1407	0	None	-3548	7	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8397408
	12	1541	17	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
	6918513	1541	17	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
	CHEMBL267615	1541	17	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
	135398745	2893	112	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	47	2893	112	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	CHEMBL715	2893	112	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	DB00334	2893	112	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	1220	187	55	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	31	187	55	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	7	187	55	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	CHEMBL56	187	55	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	1524	2168	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	197	2168	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	3822	2168	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	88	2168	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	CHEMBL51	2168	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	DB12465	2168	96	None	-169	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	267	1435	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
	9847259	1435	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
	CHEMBL4214961	1435	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
	1346	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	280	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	9899402	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	CHEMBL9666	83	117	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	10531	1408	21	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	121	1408	21	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	888	1408	21	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	CHEMBL1732	1408	21	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	DB00320	1408	21	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	6918515	2594	38	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
	71	2594	38	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
	CHEMBL7318	2594	38	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
	1150	3849	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	125	3849	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	CHEMBL6640	3849	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	DB08653	3849	121	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	135398745	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	135398745	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	47	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	47	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	CHEMBL715	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	CHEMBL715	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	DB00334	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	DB00334	2893	112	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	277	1289	62	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	2913	1289	62	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	765	1289	62	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	CHEMBL516	1289	62	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	DB00434	1289	62	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	108029	3389	57	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
	23	3389	57	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
	CHEMBL18785	3389	57	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
	3652	4066	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	57	4066	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	60809	4066	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	CHEMBL21536	4066	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	DB15357	4066	79	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	1220	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	1220	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	1220	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	1220	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	31	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	31	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	31	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	31	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	7	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	7	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	7	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	7	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	CHEMBL56	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	CHEMBL56	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	CHEMBL56	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	CHEMBL56	187	55	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	180	400	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	200	400	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	2160	400	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	CHEMBL629	400	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	DB00321	400	56	None	-125	40	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	10257	735	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	144	735	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	CHEMBL416526	735	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	DB01445	735	31	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	37459	743	13	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
	62	743	13	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
	CHEMBL8514	743	13	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
	282	1407	0	None	-1122	7	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8394987
	522609	1407	0	None	-1122	7	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8394987
	3294	1993	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	71360	1993	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	87	1993	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	CHEMBL14376	1993	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	DB04946	1993	111	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	135	2515	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	1796	2515	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	4184	2515	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	CHEMBL6437	2515	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	DB06148	2515	43	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	1613	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	1613	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	205	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	205	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	3964	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	3964	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	CHEMBL831	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	CHEMBL831	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	DB00408	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	DB00408	2333	53	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	5074	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	5074	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	97	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	97	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	CHEMBL267777	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	CHEMBL267777	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	DB12693	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	DB12693	3307	80	None	-69	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	1342	36	49	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
	3	36	49	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
	CHEMBL277120	36	49	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
	100	3776	58	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	2637	3776	58	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	5452	3776	58	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	CHEMBL479	3776	58	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	DB00679	3776	58	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	135	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	135	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	1796	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	1796	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	4184	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	4184	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	CHEMBL6437	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	CHEMBL6437	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	DB06148	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	DB06148	2515	43	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	62865	1263	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	746	1263	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	84	1263	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	CHEMBL2104153	1263	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	DB09000	1263	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	209	3035	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	2113	3035	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	4748	3035	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	CHEMBL567	3035	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	DB00850	3035	97	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	2470	3626	50	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	3300	3626	50	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	5265	3626	50	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	99	3626	50	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	CHEMBL267930	3626	50	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	100	3776	58	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	2637	3776	58	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	5452	3776	58	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	CHEMBL479	3776	58	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	DB00679	3776	58	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	277	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	277	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	2913	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	2913	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	765	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	765	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	CHEMBL516	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	CHEMBL516	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	DB00434	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	DB00434	1289	62	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	1043	1569	14	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	149	1569	14	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	8223	1569	14	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	CHEMBL442	1569	14	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	DB00696	1569	14	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	1220	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	1220	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	31	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	31	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	7	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	7	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	CHEMBL56	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	CHEMBL56	187	55	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	191	402	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	201	402	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	2170	402	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	CHEMBL1113	402	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	DB00543	402	98	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	135398737	955	93	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	38	955	93	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	722	955	93	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	CHEMBL42	955	93	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	DB00363	955	93	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	134	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	134	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	134	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	1775	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	1775	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	1775	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	9681	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	9681	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	9681	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	CHEMBL1065	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	CHEMBL1065	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	CHEMBL1065	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	DB00247	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	DB00247	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	DB00247	2497	24	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	135	2515	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	1796	2515	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	4184	2515	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	CHEMBL6437	2515	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	DB06148	2515	43	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	2470	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	2470	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	2470	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	3300	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	3300	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	3300	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	5265	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	5265	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	5265	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	99	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	99	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	99	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	CHEMBL267930	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	CHEMBL267930	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	CHEMBL267930	3626	50	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	135398737	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	135398737	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	135398737	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	38	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	38	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	38	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	722	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	722	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	722	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	CHEMBL42	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	CHEMBL42	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	CHEMBL42	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	DB00363	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	DB00363	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	DB00363	955	93	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	10171	57	18	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
	272	57	18	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
	CHEMBL274384	57	18	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
	37459	743	13	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
	62	743	13	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
	CHEMBL8514	743	13	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
	279	1648	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
	49381	1648	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
	CHEMBL63756	1648	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
	133	2479	52	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	1723	2479	52	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	28693	2479	52	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	CHEMBL19215	2479	52	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	DB13520	2479	52	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	145	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	1832	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	CHEMBL7257	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	DB14010	140	49	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	1342	36	49	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
	3	36	49	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
	CHEMBL277120	36	49	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
	2726	916	68	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	2726	916	68	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	621	916	68	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	621	916	68	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	83	916	68	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	83	916	68	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	CHEMBL71	916	68	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	CHEMBL71	916	68	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	DB00477	916	68	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	DB00477	916	68	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	206	2476	16	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
	68848	2476	16	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
	CHEMBL12314	2476	16	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
	209	3035	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	2113	3035	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	4748	3035	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	CHEMBL567	3035	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	DB00850	3035	97	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	31101	726	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	35	726	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	403	726	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	CHEMBL493	726	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	DB01200	726	40	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	1150	3849	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	125	3849	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	CHEMBL6640	3849	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	DB08653	3849	121	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	135398737	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	135398737	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	135398737	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	135398737	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	38	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	38	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	38	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	38	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	722	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	722	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	722	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	722	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	CHEMBL42	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	CHEMBL42	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	CHEMBL42	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	CHEMBL42	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	DB00363	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	DB00363	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	DB00363	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	DB00363	955	93	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	3294	1993	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	71360	1993	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	87	1993	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	CHEMBL14376	1993	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	DB04946	1993	111	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	163839	2934	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
	268	2934	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
	CHEMBL55171	2934	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
	5074	3307	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	97	3307	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	CHEMBL267777	3307	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	DB12693	3307	80	None	-36	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	206	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
	206	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
	206	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
	206	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
	68848	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
	68848	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
	68848	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
	68848	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
	CHEMBL12314	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
	CHEMBL12314	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
	CHEMBL12314	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
	CHEMBL12314	2476	16	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
	2470	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	2470	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	3300	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	3300	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	5265	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	5265	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	99	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	99	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	CHEMBL267930	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	CHEMBL267930	3626	50	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	1212	1649	50	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	204	1649	50	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	3372	1649	50	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	CHEMBL726	1649	50	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	DB00623	1649	50	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	134	2497	24	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	134	2497	24	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	1775	2497	24	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	1775	2497	24	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	9681	2497	24	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	9681	2497	24	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	CHEMBL1065	2497	24	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	CHEMBL1065	2497	24	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	DB00247	2497	24	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	DB00247	2497	24	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	133	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	133	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	1723	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	1723	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	28693	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	28693	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	CHEMBL19215	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	CHEMBL19215	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	DB13520	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	DB13520	2479	52	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	206	2476	16	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
	68848	2476	16	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
	CHEMBL12314	2476	16	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
	10171	57	18	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
	272	57	18	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
	CHEMBL274384	57	18	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
	10531	1408	21	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	121	1408	21	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	888	1408	21	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	CHEMBL1732	1408	21	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	DB00320	1408	21	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	154	2344	0	None	-12	4	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	638252	2344	0	None	-12	4	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	1212	1649	50	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	204	1649	50	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	3372	1649	50	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	CHEMBL726	1649	50	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	DB00623	1649	50	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	107	141	121	None	-9	31	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
	1833	141	121	None	-9	31	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
	CHEMBL8165	141	121	None	-9	31	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
	4106	2485	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	5358812	2485	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	89	2485	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	CHEMBL93240	2485	22	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	122	1425	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	156314	1425	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	CHEMBL1332062	1425	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	5	139	72	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	5202	139	72	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	CHEMBL39	139	72	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	DB08839	139	72	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	279	1648	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
	49381	1648	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
	CHEMBL63756	1648	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
	283	3108	57	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
	4847	3108	57	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
	CHEMBL18331	3108	57	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
	2865	4112	73	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	59	4112	73	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	60854	4112	73	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	CHEMBL708	4112	73	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	DB00246	4112	73	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	103	4122	61	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	2875	4122	61	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	5736	4122	61	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	CHEMBL285802	4122	61	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	DB09225	4122	61	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	2389	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	2389	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	5073	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	5073	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	96	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	96	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	CHEMBL85	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	CHEMBL85	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	DB00734	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	DB00734	3306	118	None	-8	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	133	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	133	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	133	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	1723	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	1723	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	1723	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	28693	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	28693	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	28693	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	CHEMBL19215	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	CHEMBL19215	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	CHEMBL19215	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	DB13520	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	DB13520	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	DB13520	2479	52	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	2105	3032	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	47811	3032	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	48	3032	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	CHEMBL531	3032	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	DB01186	3032	37	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	1588	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	1588	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	28864	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	28864	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	43	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	43	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	CHEMBL157138	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	CHEMBL157138	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	DB00589	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	DB00589	2311	27	None	-6	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	103	4122	61	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	2875	4122	61	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	5736	4122	61	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	CHEMBL285802	4122	61	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	DB09225	4122	61	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	5	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	5	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	5	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	5	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	5	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	5202	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	5202	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	5202	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	5202	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	5202	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	CHEMBL39	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	CHEMBL39	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	CHEMBL39	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	CHEMBL39	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	CHEMBL39	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	DB08839	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	DB08839	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	DB08839	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	DB08839	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	DB08839	139	72	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	107	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
	107	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
	107	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
	1833	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
	1833	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
	1833	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
	CHEMBL8165	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
	CHEMBL8165	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
	CHEMBL8165	141	121	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
	4106	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	4106	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	4106	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	4106	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	5358812	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	5358812	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	5358812	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	5358812	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	89	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	89	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	89	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	89	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	CHEMBL93240	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	CHEMBL93240	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	CHEMBL93240	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	CHEMBL93240	2485	22	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	107	141	121	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
	107	141	121	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
	1833	141	121	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
	1833	141	121	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
	CHEMBL8165	141	121	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
	CHEMBL8165	141	121	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
	1809	134	32	None	-12	37	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
	4	134	32	None	-12	37	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
	CHEMBL18840	134	32	None	-12	37	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
	4106	2485	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	5358812	2485	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	89	2485	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	CHEMBL93240	2485	22	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	101	3793	24	None	-2	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
	55752	3793	24	None	-2	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
	CHEMBL35057	3793	24	None	-2	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
	1809	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
	1809	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
	1809	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	1809	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
	4	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
	4	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
	4	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	4	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
	CHEMBL18840	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
	CHEMBL18840	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
	CHEMBL18840	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	CHEMBL18840	134	32	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
	1809	134	32	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
	1809	134	32	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408
	4	134	32	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
	4	134	32	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408
	CHEMBL18840	134	32	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
	CHEMBL18840	134	32	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408

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