Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	216416	118358	48	None	-117	23	Human	5.0	pAC50	=	5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	118358	48	None	-117	23	Human	5.0	pAC50	=	5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	319	8106	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	8106	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	8106	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	8106	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	8106	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	8106	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	11504295	9697	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	9697	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	9697	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	9697	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	9697	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4151	10379	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	493	10379	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125	10379	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL24778	10379	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	DB06207	10379	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	2855	10904	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	10904	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	10904	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	10904	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	10904	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	4066	211405	78	None	-630	16	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	211405	78	None	-630	16	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	242	7258	124	None	-72	32	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	7258	124	None	-72	32	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	7258	124	None	-72	32	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	7258	124	None	-72	32	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	7258	124	None	-72	32	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	37	7565	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	7565	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	7565	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	7565	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	7565	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	6230	17092	63	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	0	1	2	3.5	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1162	17092	63	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	0	1	2	3.5	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	4746	211670	31	None	-10	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	211670	31	None	-10	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	211670	31	None	-10	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	134	9292	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	9292	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	9292	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	9292	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	9292	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	2335	18620	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	18620	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	18620	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	18620	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	60606	68334	73	None	-5	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	68334	73	None	-5	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	27812	73765	43	None	1	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1868702	73765	43	None	1	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	2472	74058	48	None	-19	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	1	7	2.1	CCCC(=O)N1CCCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1	10.1038/s41467-023-40064-9
	CHEMBL188185	74058	48	None	-19	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	1	7	2.1	CCCC(=O)N1CCCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1	10.1038/s41467-023-40064-9
	5639	105671	75	None	-218	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	105671	75	None	-218	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	447715	203706	68	None	-18	7	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	203706	68	None	-18	7	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1028	7079	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	7079	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	7079	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	7079	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	7079	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	7079	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2683	10606	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	5487	10606	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	7308	10606	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	CHEMBL1079	10606	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	DB00697	10606	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	68617	212306	62	None	-10	30	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	212306	62	None	-10	30	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	212306	62	None	-10	30	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	10219	195575	37	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL493439	195575	37	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL50588	195575	37	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	102	10899	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	10899	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	10899	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	10899	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	10899	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	168871	95905	14	None	-9	13	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	95905	14	None	-9	13	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	17676	13844	29	None	-275	13	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	13844	29	None	-275	13	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	13844	29	None	-275	13	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5472	212597	75	None	-1	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	212597	75	None	-1	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	212597	75	None	-1	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	26248	168318	102	None	-1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	168318	102	None	-1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	31703	201496	63	None	-19	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	201496	63	None	-19	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	201496	63	None	-19	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2402	10143	62	None	-616	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	10143	62	None	-616	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	10143	62	None	-616	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	10143	62	None	-616	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	10143	62	None	-616	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	441074	26186	82	None	-9	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	26186	82	None	-9	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	1353	8692	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	8692	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	8692	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	8692	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	8692	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3149	19386	15	None	-35	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	19386	15	None	-35	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	3316	38534	71	None	-23	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	38534	71	None	-23	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	636403	195047	22	None	-5	7	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	195047	22	None	-5	7	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	179	7188	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	2159	7188	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	963	7188	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	CHEMBL243712	7188	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	DB06288	7188	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	68712	107114	60	None	1	7	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	CHEMBL289480	107114	60	None	1	7	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	2105	9828	37	None	-91	24	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	9828	37	None	-91	24	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	9828	37	None	-91	24	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	9828	37	None	-91	24	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	9828	37	None	-91	24	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	11079	9510	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	9510	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	9510	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	9510	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	9510	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	9510	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3157	8252	71	None	-5370	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	8252	71	None	-5370	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	8252	71	None	-5370	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	8252	71	None	-5370	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	8252	71	None	-5370	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	1212	8443	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	8443	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	8443	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	8443	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	8443	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	119570	9933	96	None	-3019	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	9933	96	None	-3019	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	9933	96	None	-3019	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	9933	96	None	-3019	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	9933	96	None	-3019	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	4209	9937	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	9937	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	9937	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	9937	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	9937	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	9937	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	2780	117306	36	None	-1479	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	117306	36	None	-1479	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	5453	210398	102	None	-323	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	210398	102	None	-323	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	4477	43310	90	None	-13	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	43310	90	None	-13	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	214	10632	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	10632	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	10632	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	10632	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	10632	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	10632	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	11626560	207716	94	None	-16	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	207716	94	None	-16	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	135398737	7745	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	7745	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	7745	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	7745	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	7745	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1593	9119	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668	9119	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	9868	9119	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL17860	9119	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	DB04948	9119	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	1816	9318	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	9318	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	9318	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	9318	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	9318	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	2146	9874	67	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	9874	67	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	9874	67	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	9874	67	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	9874	67	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	13314	91008	15	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	91008	15	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	2142	9870	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	9870	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	9870	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	9870	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	9870	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	9870	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	2343	21226	57	None	-1	4	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
	CHEMBL1201039	21226	57	None	-1	4	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
	150	9287	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	9287	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	9287	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	9287	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	9287	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	392622	63086	95	None	-14	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	63086	95	None	-14	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	68602	211905	80	None	-10	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
	CHEMBL77921	211905	80	None	-10	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
	1201549	7384	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	7384	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	7384	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	7384	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	7384	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	7384	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	6018	17837	96	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	17837	96	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	2601	10552	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	10552	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	10552	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	10552	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	10552	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	4567	16720	34	None	-239	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	16720	34	None	-239	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	41684	37995	105	None	-42	32	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	37995	105	None	-42	32	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	25102847	84996	93	None	-15	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	84996	93	None	-15	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	443955	211149	92	None	-17	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	211149	92	None	-17	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	16363	7383	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	7383	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	7383	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	7383	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	7383	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2435	7509	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	395	7509	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	520	7509	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5386	7509	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL844	7509	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	DB00484	7509	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	82153	50675	45	None	-41	3	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	CHEMBL1512	50675	45	None	-41	3	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	11980903	21264	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	21264	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	21264	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	21264	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	610479	22272	90	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	22272	90	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	2448	106099	70	None	-912	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	106099	70	None	-912	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	1830	9368	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	9368	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	9368	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	9368	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	9368	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	3081361	100709	123	None	-3	14	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	100709	123	None	-3	14	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	2318	161635	29	None	-32	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	161635	29	None	-32	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	154257	185398	67	None	-10	19	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	185398	67	None	-10	19	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	10102	9324	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	1824	9324	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906	9324	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	CHEMBL94454	9324	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	DB12523	9324	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	4260	59332	31	None	-20	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	CHEMBL159226	59332	31	None	-20	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	53276	101809	53	None	-1	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	CHEMBL255044	101809	53	None	-1	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	5329102	201505	86	None	-138	37	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	201505	86	None	-138	37	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	4452	9538	19	None	-8317	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	9538	19	None	-8317	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	9538	19	None	-8317	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	6337614	19768	54	None	-22	6	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1189679	19768	54	None	-22	6	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
	1234	196000	56	None	-95	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	196000	56	None	-95	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	196000	56	None	-95	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	65859	25821	88	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	236	4	2	4	0.2	OC[C@@H](O)CN1CCN(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1288810	25821	88	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	236	4	2	4	0.2	OC[C@@H](O)CN1CCN(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	47979	84985	59	None	-8709	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	84985	59	None	-8709	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	68712	107114	60	None	1	7	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	CHEMBL289480	107114	60	None	1	7	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	1960	9632	67	None	-13	19	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	9632	67	None	-13	19	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	9632	67	None	-13	19	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	9632	67	None	-13	19	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	9632	67	None	-13	19	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	4031	106089	28	None	-4	12	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	106089	28	None	-4	12	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	31508	103993	38	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	3	4.0	Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1	10.1038/s41467-023-40064-9
	CHEMBL268501	103993	38	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	3	4.0	Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1	10.1038/s41467-023-40064-9
	2146	9874	67	None	-123	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	9874	67	None	-123	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	9874	67	None	-123	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	9874	67	None	-123	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	9874	67	None	-123	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	5284550	48495	15	None	-1513	16	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	48495	15	None	-1513	16	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	5210	40112	48	None	-7	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	40112	48	None	-7	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	40112	48	None	-7	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	1043	8363	14	None	-128	23	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	8363	14	None	-128	23	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	8363	14	None	-128	23	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	8363	14	None	-128	23	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	8363	14	None	-128	23	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	10133	7697	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	7697	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	7697	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	7697	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	7697	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	7697	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	2585	7590	103	None	-512	34	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	7590	103	None	-512	34	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	7590	103	None	-512	34	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	7590	103	None	-512	34	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	7590	103	None	-512	34	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2136	9869	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	9869	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	9869	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	9869	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	9869	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	103	10925	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	10925	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	10925	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	10925	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	10925	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	65700	85035	28	None	-9	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	85035	28	None	-9	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	213	10625	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	10625	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	10625	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	10625	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	10625	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	68555	109889	21	None	-79	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	109889	21	None	-79	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	2803	7742	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	516	7742	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	704	7742	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	CHEMBL134	7742	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	DB00575	7742	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	47319	33237	35	None	-1	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1360	33237	35	None	-1	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	2407	10145	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	10145	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	10145	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	10145	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	10145	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	4418	40996	85	None	-19	18	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	40996	85	None	-19	18	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	10531	8202	21	None	-14	26	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	8202	21	None	-14	26	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	8202	21	None	-14	26	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	8202	21	None	-14	26	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	8202	21	None	-14	26	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2333	149113	97	None	-3	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	149113	97	None	-3	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	228	7233	28	None	-724	19	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	7233	28	None	-724	19	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	7233	28	None	-724	19	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	7233	28	None	-724	19	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	7233	28	None	-724	19	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	3689	109548	55	None	-549	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	109548	55	None	-549	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	109548	55	None	-549	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2389	10104	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	10104	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	10104	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	10104	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	10104	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2583	10548	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	10548	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	10548	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	10548	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	10548	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	2220	9908	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	9908	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	9908	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	9908	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	9908	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	1960	9632	67	None	-13	19	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	9632	67	None	-13	19	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	9632	67	None	-13	19	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	9632	67	None	-13	19	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	9632	67	None	-13	19	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	11079	9510	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	9510	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	9510	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	9510	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	9510	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	9510	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	108000	63627	39	None	-12	5	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	63627	39	None	-12	5	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	63627	39	None	-12	5	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	47936	200201	88	None	-91	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	200201	88	None	-91	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	2713	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	212050	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	3294	8787	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	8787	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	8787	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	8787	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	8787	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2470	10425	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	10425	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	10425	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	10425	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	10425	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	129211	10521	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	10521	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	10521	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	10521	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	10521	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	213046	9164	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	9164	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	9164	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	9164	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	9164	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2733	34586	112	None	1	3	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	0	1	2	1.8	O=c1[nH]c2cc(Cl)ccc2o1	10.1038/s41467-023-40064-9
	CHEMBL1371	34586	112	None	1	3	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	0	1	2	1.8	O=c1[nH]c2cc(Cl)ccc2o1	10.1038/s41467-023-40064-9
	1343	8670	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	8670	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	8670	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	8670	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	8670	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	135409453	10545	41	None	-398	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	10545	41	None	-398	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	10545	41	None	-398	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	4011	89183	49	None	-389	26	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	89183	49	None	-389	26	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2202	9906	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	9906	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	9906	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	9906	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	9906	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	212	10578	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	10578	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	10578	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	10578	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	10578	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	3658	10879	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	10879	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	10879	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	10879	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	10879	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2467	74199	51	None	-1	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	CHEMBL188921	74199	51	None	-1	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	31101	7516	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	7516	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	7516	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	7516	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	7516	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	1890	9535	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	9535	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	9535	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	9535	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	9535	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	3926	214020	40	None	-10	18	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	214020	40	None	-10	18	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	25382	15929	37	None	-181	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	15929	37	None	-181	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	115	7131	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	2092	7131	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	7109	7131	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	CHEMBL709	7131	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	DB00346	7131	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	119570	9933	96	None	-3019	10	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	9933	96	None	-3019	10	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	9933	96	None	-3019	10	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	9933	96	None	-3019	10	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	9933	96	None	-3019	10	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	445643	104164	69	None	1	7	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	104164	69	None	1	7	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	11658860	9123	51	None	-630	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	9123	51	None	-630	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	9123	51	None	-630	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	9123	51	None	-630	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	9123	51	None	-630	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	5311507	201594	41	None	-645	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	201594	41	None	-645	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	2342	7386	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	7386	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	7386	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	7386	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	7386	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	4640	85041	30	None	-61	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	85041	30	None	-61	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	56959	38330	103	None	-7	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	38330	103	None	-7	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	38330	103	None	-7	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	46780481	114308	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	114308	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	114308	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	114308	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	118422671	9533	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	9533	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	9533	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	9533	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	9533	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	9533	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	104870	105656	47	None	1	10	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	105656	47	None	1	10	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	105656	47	None	1	10	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	1028	7079	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	7079	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	7079	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	7079	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	7079	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	7079	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2695	10613	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	5504	10613	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	7310	10613	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL770	10613	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00797	10613	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	2267	7347	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	7347	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	7347	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	7347	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	7347	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	1056	10144	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	10144	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	10144	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	10144	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	10144	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	54682461	91461	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	91461	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	12574	9383	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810	9383	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	CHEMBL19236	9383	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	DB09242	9383	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	135	9310	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	9310	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	9310	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	9310	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	9310	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1574	9093	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	5359272	9093	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	7595	9093	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	CHEMBL592	9093	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	DB00854	9093	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	124	9755	47	None	-3	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	9755	47	None	-3	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	9755	47	None	-3	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	9755	47	None	-3	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	9755	47	None	-3	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	180	7189	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	7189	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	7189	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	7189	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	7189	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2169	51621	35	None	-151	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	51621	35	None	-151	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	5803	169006	84	None	-2	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	169006	84	None	-2	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	1971	9641	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	9641	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	9641	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	9641	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	9641	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2600	10551	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	10551	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	10551	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	10551	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	10551	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	40326	51895	68	None	1	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	6	0	3	6.1	CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1	10.1038/s41467-023-40064-9
	CHEMBL1525	51895	68	None	1	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	6	0	3	6.1	CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1	10.1038/s41467-023-40064-9
	2470	10425	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	10425	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	10425	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	10425	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	10425	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	4993	129135	110	None	-2	5	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	129135	110	None	-2	5	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5365247	145207	33	None	-69	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	CHEMBL37744	145207	33	None	-69	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	2435	7509	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	395	7509	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	520	7509	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	5386	7509	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	CHEMBL844	7509	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	DB00484	7509	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	521	8186	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	5311068	8186	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	835	8186	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	CHEMBL778	8186	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	DB00633	8186	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	2435	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	395	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	520	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	5386	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	CHEMBL844	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	DB00484	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	218362	211579	5	None	1	3	Human	8.9	pEC50	=	8.9	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
	CHEMBL75030	211579	5	None	1	3	Human	8.9	pEC50	=	8.9	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
	185076	193869	5	None	11	3	Human	8.9	pEC50	=	8.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL49137	193869	5	None	11	3	Human	8.9	pEC50	=	8.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	521	8186	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	5311068	8186	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	835	8186	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	CHEMBL778	8186	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	DB00633	8186	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	44314198	111189	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
	CHEMBL310335	111189	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
	9815707	108246	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
	CHEMBL297752	108246	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
	2803	7742	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	516	7742	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	704	7742	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	CHEMBL134	7742	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	DB00575	7742	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	44292232	108098	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	CHEMBL296660	108098	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	11140345	210950	0	None	-12	5	Human	7.0	pEC50	=	7	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70692	210950	0	None	-12	5	Human	7.0	pEC50	=	7	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	24906200	199935	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
	CHEMBL523048	199935	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
	11211035	91778	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
	CHEMBL223836	91778	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
	11211035	91778	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
	CHEMBL223836	91778	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
	10382537	210945	12	None	4	2	Human	7.9	pEC50	=	7.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL70676	210945	12	None	4	2	Human	7.9	pEC50	=	7.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	44371864	57915	0	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL157955	57915	0	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	1960	9632	67	None	-13	19	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	439260	9632	67	None	-13	19	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	505	9632	67	None	-13	19	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	CHEMBL1437	9632	67	None	-13	19	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	DB00368	9632	67	None	-13	19	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	44352207	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL128168	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	44352207	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL128168	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	44352207	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
	CHEMBL128168	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
	44352207	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL128168	25628	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	1960	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	439260	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	505	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	CHEMBL1437	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	DB00368	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	9859437	174801	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
	CHEMBL432155	174801	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
	1960	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	439260	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	505	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	CHEMBL1437	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	DB00368	9632	67	None	-13	19	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	50994258	66863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	3	2	1.1	Cc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641682	66863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	3	2	1.1	Cc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1739118	66863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	3	2	1.1	Cc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	53323136	63351	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641690	63351	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	44312036	211344	1	None	-19	2	Human	4.8	pEC50	=	4.8	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
	CHEMBL72995	211344	1	None	-19	2	Human	4.8	pEC50	=	4.8	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
	24882007	19245	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	CHEMBL1186220	19245	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	56950526	78283	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	234	2	1	4	1.7	Clc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1928323	78283	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	234	2	1	4	1.7	Clc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1962709	78283	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	234	2	1	4	1.7	Clc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	57400570	78277	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	214	2	1	4	1.3	Cc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1928322	78277	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	214	2	1	4	1.3	Cc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1962686	78277	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	214	2	1	4	1.3	Cc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	44371755	55551	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL155866	55551	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	24882106	19338	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2c1cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	CHEMBL1186774	19338	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2c1cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	118717249	121903	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
	CHEMBL3343700	121903	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
	11098175	210949	0	None	-186	4	Human	6.7	pEC50	=	6.7	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL70691	210949	0	None	-186	4	Human	6.7	pEC50	=	6.7	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	135399666	175542	7	None	-23	6	Human	5.7	pEC50	=	5.7	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	175542	7	None	-23	6	Human	5.7	pEC50	=	5.7	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	3086326	211310	22	None	13	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL72753	211310	22	None	13	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	131829	211506	15	None	37	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
	CHEMBL74283	211506	15	None	37	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
	44314200	109729	0	None	-9	3	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
	CHEMBL306377	109729	0	None	-9	3	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
	53324490	66866	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641681	66866	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1739173	66866	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	10934575	211265	0	None	-229	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72441	211265	0	None	-229	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
	11140347	211312	1	None	-13	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72768	211312	1	None	-13	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	11000184	19824	0	None	-74	5	Human	6.6	pEC50	=	6.6	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1190038	19824	0	None	-74	5	Human	6.6	pEC50	=	6.6	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL540035	19824	0	None	-74	5	Human	6.6	pEC50	=	6.6	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	11173568	91416	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
	CHEMBL222371	91416	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
	135453290	140384	33	None	-1318	7	Human	5.6	pEC50	=	5.6	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	140384	33	None	-1318	7	Human	5.6	pEC50	=	5.6	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	44449277	161962	2	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	214	2	1	2	2.5	COc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL402388	161962	2	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	214	2	1	2	2.5	COc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	68712	107114	60	None	1	7	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
	CHEMBL289480	107114	60	None	1	7	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
	44312037	211398	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL73392	211398	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	2803	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	516	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	704	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	CHEMBL134	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	DB00575	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	11043720	98947	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL242265	98947	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	11043720	98947	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL242265	98947	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	124	9755	47	None	-3	25	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	2032	9755	47	None	-3	25	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	4636	9755	47	None	-3	25	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	CHEMBL762	9755	47	None	-3	25	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	DB00935	9755	47	None	-3	25	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	2803	7742	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	516	7742	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	704	7742	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	CHEMBL134	7742	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	DB00575	7742	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	2146	9874	67	None	-123	15	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	485	9874	67	None	-123	15	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	6041	9874	67	None	-123	15	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	CHEMBL1215	9874	67	None	-123	15	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	DB00388	9874	67	None	-123	15	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	57402718	77964	2	None	3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL1956201	77964	2	None	3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	11265631	143187	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL373535	143187	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	11097789	109775	1	None	-52	5	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL306792	109775	1	None	-52	5	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	11265631	143187	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL373535	143187	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
	49836306	25347	0	None	-31	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL1276247	25347	0	None	-31	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	44449247	102189	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	228	2	1	2	2.8	COc1c(C)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL256984	102189	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	228	2	1	2	2.8	COc1c(C)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	9817256	211017	0	None	-251	2	Human	5.5	pEC50	=	5.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL71001	211017	0	None	-251	2	Human	5.5	pEC50	=	5.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	9971924	191005	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
	CHEMBL48341	191005	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
	44421258	91521	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
	CHEMBL1204386	91521	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
	CHEMBL222933	91521	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
	24882019	19340	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	2	3	0.7	Cc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1186788	19340	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	2	3	0.7	Cc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	1960	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	439260	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	505	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	CHEMBL1437	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	DB00368	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	1960	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	439260	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	505	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	CHEMBL1437	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	DB00368	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	1960	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	439260	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	505	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	CHEMBL1437	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	DB00368	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	1960	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	439260	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	505	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	CHEMBL1437	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	DB00368	9632	67	None	-13	19	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	294234	109670	3	None	2	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
	CHEMBL305928	109670	3	None	2	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
	118717248	121902	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
	CHEMBL3343699	121902	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
	11140033	27455	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL130884	27455	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	11108001	17644	2	None	-7	5	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aAgonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2a	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL117248	17644	2	None	-7	5	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aAgonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2a	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL540542	17644	2	None	-7	5	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aAgonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2a	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	2435	7509	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	395	7509	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	520	7509	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	5386	7509	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	CHEMBL844	7509	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	DB00484	7509	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	11360447	91776	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
	CHEMBL223829	91776	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
	10859076	20454	0	None	-83	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1194763	20454	0	None	-83	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL553276	20454	0	None	-83	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	44449276	102426	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	241	2	2	2	1.8	CNC(=O)c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257976	102426	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	241	2	2	2	1.8	CNC(=O)c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	11098175	210949	0	None	-186	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL70691	210949	0	None	-186	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	57391904	78256	2	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	200	2	1	4	1.0	c1ccc2c(c1)cnn2CC1=NCCN1	10.1016/j.bmc.2011.11.025
	CHEMBL1928316	78256	2	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	200	2	1	4	1.0	c1ccc2c(c1)cnn2CC1=NCCN1	10.1016/j.bmc.2011.11.025
	CHEMBL1962472	78256	2	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	200	2	1	4	1.0	c1ccc2c(c1)cnn2CC1=NCCN1	10.1016/j.bmc.2011.11.025
	44449691	102937	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	261	2	1	2	3.6	c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1	10.1016/j.bmcl.2008.03.070
	CHEMBL260576	102937	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	261	2	1	2	3.6	c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1	10.1016/j.bmcl.2008.03.070
	24906159	194184	12	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
	CHEMBL493675	194184	12	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
	57400959	77963	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL1956200	77963	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	11265631	143187	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL373535	143187	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	1593	9119	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	30668	9119	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	9868	9119	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	CHEMBL17860	9119	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	DB04948	9119	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	11109088	210959	0	None	-14	5	Human	8.2	pEC50	=	8.2	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70751	210959	0	None	-14	5	Human	8.2	pEC50	=	8.2	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	57395731	77965	0	None	3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL1956202	77965	0	None	3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	49836305	25348	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL1276248	25348	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	24906199	194444	15	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
	CHEMBL495096	194444	15	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
	44292386	108259	0	None	-35	2	Human	7.2	pEC50	=	7.2	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	CHEMBL297827	108259	0	None	-35	2	Human	7.2	pEC50	=	7.2	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	17804479	102435	19	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	198	1	1	1	2.9	c1ccc2c(c1)CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL258007	102435	19	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	198	1	1	1	2.9	c1ccc2c(c1)CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	50994260	66865	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2c(N=C3NCCN3)n[nH]c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641689	66865	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2c(N=C3NCCN3)n[nH]c12	10.1016/j.bmc.2010.11.020
	CHEMBL1739136	66865	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2c(N=C3NCCN3)n[nH]c12	10.1016/j.bmc.2010.11.020
	10333157	158017	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL396013	158017	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	10333157	158017	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL396013	158017	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	11371902	148416	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL385310	148416	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
	11371902	148416	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL385310	148416	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	23622576	179551	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
	CHEMBL451229	179551	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
	2803	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	516	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	704	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	CHEMBL134	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	DB00575	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	2803	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	516	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	704	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	CHEMBL134	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	DB00575	7742	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	10176999	110331	21	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
	CHEMBL308570	110331	21	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
	53322686	66867	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	3	2	0.7	c1ccc2c(N=C3NCCN3)n[nH]c2c1	10.1016/j.bmc.2010.11.020
	CHEMBL1641679	66867	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	3	2	0.7	c1ccc2c(N=C3NCCN3)n[nH]c2c1	10.1016/j.bmc.2010.11.020
	CHEMBL1739201	66867	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	3	2	0.7	c1ccc2c(N=C3NCCN3)n[nH]c2c1	10.1016/j.bmc.2010.11.020
	15675860	211208	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
	CHEMBL72147	211208	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
	2683	10606	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	5487	10606	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	7308	10606	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	CHEMBL1079	10606	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	DB00697	10606	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	24882007	19245	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
	CHEMBL1186220	19245	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
	132111	109772	5	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL306751	109772	5	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	132111	109772	5	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL306751	109772	5	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	123132228	163085	53	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	369	5	1	8	2.4	CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1	10.1021/acs.jmedchem.1c02148
	CHEMBL4065484	163085	53	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	369	5	1	8	2.4	CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1	10.1021/acs.jmedchem.1c02148
	11820372	20262	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	208	2	1	1	3.2	c1ccc2c(Cc3c[nH]cn3)cccc2c1	10.1021/jm00041a011
	CHEMBL1193371	20262	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	208	2	1	1	3.2	c1ccc2c(Cc3c[nH]cn3)cccc2c1	10.1021/jm00041a011
	CHEMBL544765	20262	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	208	2	1	1	3.2	c1ccc2c(Cc3c[nH]cn3)cccc2c1	10.1021/jm00041a011
	68602	211905	80	None	-10	4	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1021/jm00041a011
	CHEMBL77921	211905	80	None	-10	4	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1021/jm00041a011
	10376336	19975	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	224	2	2	2	2.6	OC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL1191106	19975	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	224	2	2	2	2.6	OC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL542155	19975	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	224	2	2	2	2.6	OC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	132111	109772	5	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL306751	109772	5	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	132256889	197226	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	378	5	1	7	3.6	COc1cccc(F)c1CNc1ccc(-c2cnc(C)nc2C)c2nncn12	10.1021/acs.jmedchem.1c02148
	CHEMBL5178464	197226	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	378	5	1	7	3.6	COc1cccc(F)c1CNc1ccc(-c2cnc(C)nc2C)c2nncn12	10.1021/acs.jmedchem.1c02148
	CHEMBL4755618	220820	39	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Agonist activity at adrenergic receptor alpha2a (unknown origin)Agonist activity at adrenergic receptor alpha2a (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	13305910	18608	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182155	18608	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL215421	18608	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL3741808	18608	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	16121006	18613	0	None	-	0	Rat	5.9	pKd	=	5.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182182	18613	0	None	-	0	Rat	5.9	pKd	=	5.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL217469	18613	0	None	-	0	Rat	5.9	pKd	=	5.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	499	10849	18	None	-	1	Rat	6.6	pKd	=	6.6	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	5685	10849	18	None	-	1	Rat	6.6	pKd	=	6.6	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	CHEMBL25554	10849	18	None	-	1	Rat	6.6	pKd	=	6.6	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	6603808	134300	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL214986	134300	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL36622	134300	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL3740374	134300	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	44417713	19194	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1185884	19194	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL439346	19194	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	44324800	213727	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	CHEMBL91157	213727	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	44324972	170151	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	CHEMBL419316	170151	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	44579272	193874	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
	CHEMBL491420	193874	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
	10758200	70191	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	CHEMBL179648	70191	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	44579184	197732	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	CHEMBL518592	197732	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	44579271	193873	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	CHEMBL491419	193873	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	44579228	188433	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	CHEMBL477608	188433	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	44404321	77067	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	297	4	1	5	3.0	COc1cccc(N(NC2=NCCO2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
	CHEMBL194323	77067	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	297	4	1	5	3.0	COc1cccc(N(NC2=NCCO2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
	44579185	188593	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
	CHEMBL477816	188593	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
	44579230	188323	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
	CHEMBL476569	188323	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
	44324737	214017	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
	CHEMBL92860	214017	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
	44579187	196458	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
	CHEMBL515331	196458	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
	44579229	196395	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	CHEMBL514837	196395	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	2683	10606	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	5487	10606	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	7308	10606	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	CHEMBL1079	10606	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	DB00697	10606	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	1343	8670	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	3519	8670	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	522	8670	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	CHEMBL862	8670	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	DB01018	8670	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	2435	7509	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	395	7509	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	520	7509	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	5386	7509	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	CHEMBL844	7509	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	DB00484	7509	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	521	8186	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	5311068	8186	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	835	8186	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	CHEMBL778	8186	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	DB00633	8186	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	523	10878	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	5707	10878	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	CHEMBL297362	10878	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	DB11477	10878	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	1960	9632	67	None	-13	19	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	439260	9632	67	None	-13	19	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	505	9632	67	None	-13	19	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	CHEMBL1437	9632	67	None	-13	19	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	DB00368	9632	67	None	-13	19	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	1028	7079	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	139148732	7079	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	479	7079	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	5816	7079	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	CHEMBL679	7079	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	DB00668	7079	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	1343	8670	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	3519	8670	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	522	8670	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	CHEMBL862	8670	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	DB01018	8670	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	2803	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	516	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	704	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	CHEMBL134	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	DB00575	7742	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	3952	8669	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	5353646	8669	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	5443	8669	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	5702063	8669	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	CHEMBL1331786	8669	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	CHEMBL420	8669	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	521	8186	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	5311068	8186	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	835	8186	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	CHEMBL778	8186	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	DB00633	8186	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	523	10878	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	5707	10878	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	CHEMBL297362	10878	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	DB11477	10878	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	1960	9632	67	None	-13	19	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	439260	9632	67	None	-13	19	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	505	9632	67	None	-13	19	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL1437	9632	67	None	-13	19	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00368	9632	67	None	-13	19	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	1028	7079	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	139148732	7079	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	479	7079	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	5816	7079	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL679	7079	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00668	7079	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	2683	10606	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	5487	10606	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	7308	10606	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	CHEMBL1079	10606	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	DB00697	10606	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	12574	9383	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	4810	9383	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	CHEMBL19236	9383	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	DB09242	9383	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	2803	7742	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	516	7742	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	704	7742	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	CHEMBL134	7742	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	DB00575	7742	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	1343	8670	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3519	8670	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	522	8670	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	CHEMBL862	8670	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	DB01018	8670	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	2435	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	395	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	520	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	5386	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	CHEMBL844	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	DB00484	7509	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	3952	8669	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5353646	8669	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5443	8669	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5702063	8669	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL1331786	8669	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL420	8669	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	521	8186	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	5311068	8186	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	835	8186	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	CHEMBL778	8186	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	DB00633	8186	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	523	10878	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	5707	10878	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	CHEMBL297362	10878	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	DB11477	10878	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	1960	9632	67	None	-13	19	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	439260	9632	67	None	-13	19	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	505	9632	67	None	-13	19	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL1437	9632	67	None	-13	19	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00368	9632	67	None	-13	19	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	1028	7079	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	139148732	7079	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	479	7079	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	5816	7079	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL679	7079	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00668	7079	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	12574	9383	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	4810	9383	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	CHEMBL19236	9383	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	DB09242	9383	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	2683	10606	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	5487	10606	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	7308	10606	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	CHEMBL1079	10606	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	DB00697	10606	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	2803	7742	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	516	7742	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	704	7742	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	CHEMBL134	7742	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	DB00575	7742	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	1343	8670	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3519	8670	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	522	8670	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	CHEMBL862	8670	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	DB01018	8670	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	2142	9870	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	4920903	9870	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	502	9870	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	5775	9870	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	CHEMBL597	9870	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	DB00692	9870	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	521	8186	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	5311068	8186	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	835	8186	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	CHEMBL778	8186	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	DB00633	8186	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	2136	9869	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	4768	9869	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	7268	9869	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	CHEMBL753	9869	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	DB00925	9869	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	176	7186	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	7186	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	7186	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	7186	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	7186	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	1816	9318	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	4205	9318	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	7241	9318	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	CHEMBL654	9318	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	DB00370	9318	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	3952	8669	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5353646	8669	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5443	8669	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5702063	8669	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL1331786	8669	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL420	8669	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	1028	7079	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	139148732	7079	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	479	7079	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	5816	7079	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL679	7079	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00668	7079	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	523	10878	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	5707	10878	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	CHEMBL297362	10878	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	DB11477	10878	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	1960	9632	67	None	-13	19	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	439260	9632	67	None	-13	19	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	505	9632	67	None	-13	19	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL1437	9632	67	None	-13	19	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00368	9632	67	None	-13	19	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	12574	9383	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	4810	9383	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	CHEMBL19236	9383	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	DB09242	9383	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	2683	10606	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	5487	10606	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	7308	10606	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	CHEMBL1079	10606	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	DB00697	10606	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	11079	9510	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	3369	9510	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	4436	9510	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	5509	9510	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	CHEMBL761	9510	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	DB06711	9510	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	3952	8669	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5353646	8669	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5443	8669	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5702063	8669	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL1331786	8669	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL420	8669	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	1343	8670	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3519	8670	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	522	8670	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	CHEMBL862	8670	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	DB01018	8670	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3658	10879	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	517	10879	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	5709	10879	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	CHEMBL312448	10879	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	DB06694	10879	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	2803	7742	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	516	7742	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	704	7742	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	CHEMBL134	7742	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	DB00575	7742	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	124	9755	47	None	-3	25	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	2032	9755	47	None	-3	25	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	4636	9755	47	None	-3	25	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	CHEMBL762	9755	47	None	-3	25	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	DB00935	9755	47	None	-3	25	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	2435	7509	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	395	7509	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	520	7509	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	5386	7509	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	CHEMBL844	7509	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	DB00484	7509	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	521	8186	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	5311068	8186	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	835	8186	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	CHEMBL778	8186	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	DB00633	8186	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		1353	8692	93	None	-190	85	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-190	85	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-190	85	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-190	85	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-190	85	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		15387	52596	55	None	-1	24	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1531134	52596	55	None	-1	24	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		37	7565	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	7565	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	7565	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	7565	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	7565	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		5591	164310	90	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		CHEMBL408	164310	90	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		5022	8432	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		6918248	8432	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		8182	8432	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL231068	8432	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		DB04908	8432	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		176	7186	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	7186	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	7186	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	7186	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	7186	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		3152	195190	103	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	195190	103	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		2335	18620	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	18620	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	18620	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	18620	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		135	9310	43	None	-4	56	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-4	56	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-4	56	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-4	56	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-4	56	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		98941	53724	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL154126	53724	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		103	10925	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	10925	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	10925	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	10925	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	10925	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		36811	8236	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		535	8236	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		937	8236	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL926	8236	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		DB00841	8236	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		5330286	74345	104	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		CHEMBL189963	74345	104	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		4908	195585	78	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		CHEMBL506	195585	78	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		1343	8670	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3519	8670	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		522	8670	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		CHEMBL862	8670	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		DB01018	8670	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3351	101777	52	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
		CHEMBL254857	101777	52	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
		2389	10104	118	None	-77	66	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	10104	118	None	-77	66	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	10104	118	None	-77	66	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	10104	118	None	-77	66	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	10104	118	None	-77	66	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5360696	8188	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		6953	8188	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		842	8188	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		CHEMBL52440	8188	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		DB00514	8188	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		460612	212823	66	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		6918992	212823	66	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL852	212823	66	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-26	90	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-26	90	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-26	90	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-26	90	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-26	90	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		21722	24764	31	None	-	6	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		CHEMBL126224	24764	31	None	-	6	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		5351322	101566	38	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL25336	101566	38	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		3584	10549	64	None	-251	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	10549	64	None	-251	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	10549	64	None	-251	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	10549	64	None	-251	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	10549	64	None	-251	14	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		129893322	35391	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		4923	35391	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353897	35391	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		6178111	35391	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1377	35391	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		237	211644	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL546257	211644	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL554190	211644	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL7568	211644	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		2402	10143	62	None	-5	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	10143	62	None	-5	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	10143	62	None	-5	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	10143	62	None	-5	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	10143	62	None	-5	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		25295	20392	37	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1194287	20392	37	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		71698	210208	35	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	262	6	3	3	2.2	Cc1cc2c(OCC(O)CNC(C)C)cccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL65717	210208	35	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	262	6	3	3	2.2	Cc1cc2c(OCC(O)CNC(C)C)cccc2[nH]1	10.1038/s41467-023-40064-9
		180	7189	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		5584	209990	44	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL644	209990	44	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		1400	8738	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	8738	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	8738	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	8738	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	8738	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	8738	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		4151	10379	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		493	10379	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		5312125	10379	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL24778	10379	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		DB06207	10379	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		56959	38330	103	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
		CHEMBL1404	38330	103	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
		CHEMBL1526084	38330	103	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
		46780481	114308	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	114308	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	114308	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	114308	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		1593	9119	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		30668	9119	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		9868	9119	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL17860	9119	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		DB04948	9119	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		1153	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		12668023	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026874	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026875	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		3341	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		6603851	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		933	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		939	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		985	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1160786	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1161520	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL588	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		DB00800	8409	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		2683	10606	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		5487	10606	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		7308	10606	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		CHEMBL1079	10606	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		DB00697	10606	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		1909	9598	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		2559	9598	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		4474	9598	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL1484	9598	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL3302409	9598	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		DB00622	9598	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		3053	211913	95	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		CHEMBL780	211913	95	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		242	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		9853053	127297	74	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		CHEMBL354541	127297	74	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		93154	12208	29	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL107360	12208	29	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		68602	211905	80	None	-1	8	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		CHEMBL77921	211905	80	None	-1	8	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		5625	206447	72	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	10.1038/s41467-023-40064-9
		CHEMBL593	206447	72	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	10.1038/s41467-023-40064-9
		208898	72973	78	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		CHEMBL184412	72973	78	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		3627	50903	18	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1515447	50903	18	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		2683	10606	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		5487	10606	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		7308	10606	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		CHEMBL1079	10606	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		DB00697	10606	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		3652	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		57	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		60809	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		CHEMBL21536	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		DB15357	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		3354	48558	50	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		CHEMBL1493	48558	50	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		319	8106	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	8106	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	8106	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	8106	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	8106	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	8106	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		1343	8670	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3519	8670	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		522	8670	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		CHEMBL862	8670	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		DB01018	8670	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		102	10899	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	10899	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	10899	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	10899	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	10899	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		242	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		2540	11173	111	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1014	11173	111	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		1890	9535	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	9535	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	9535	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	9535	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	9535	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		1613	9127	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	9127	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	9127	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	9127	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	9127	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		9429	208912	58	None	-	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	208912	58	None	-	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		11057	182928	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3468	182928	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL459265	182928	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL64894	182928	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3607	43156	72	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		CHEMBL144673	43156	72	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		16564	211774	32	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		CHEMBL76725	211774	32	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		21855	91021	42	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL22108	91021	42	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		5472	212597	75	None	-1	3	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1717	212597	75	None	-1	3	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
		CHEMBL833	212597	75	None	-1	3	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
		3152	195190	103	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	195190	103	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		10531	8202	21	None	-5	24	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	8202	21	None	-5	24	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	8202	21	None	-5	24	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	8202	21	None	-5	24	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	8202	21	None	-5	24	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		68617	212306	62	None	-3	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1709	212306	62	None	-3	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL809	212306	62	None	-3	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		1935	10506	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		2551	10506	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		6687	10506	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL95	10506	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00382	10506	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		213046	9164	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	9164	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	9164	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	9164	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	9164	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		5314	210887	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	9	0	4	0.3	C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL703	210887	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	9	0	4	0.3	C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		7019	174755	106	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1308088	174755	106	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43184	174755	106	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		2470	10425	50	None	-	58	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3300	10425	50	None	-	58	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		5265	10425	50	None	-	58	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		99	10425	50	None	-	58	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL267930	10425	50	None	-	58	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		25151352	147384	67	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	147384	67	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		68602	211905	80	None	-1	8	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		CHEMBL77921	211905	80	None	-1	8	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		3634	90883	51	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL22077	90883	51	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		104903	63118	17	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1630578	63118	17	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		3294	8787	111	None	-47	44	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	8787	111	None	-47	44	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	8787	111	None	-47	44	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	8787	111	None	-47	44	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	8787	111	None	-47	44	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		3561	25849	39	None	-1	11	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1289	25849	39	None	-1	11	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		3157	8252	71	None	-61	12	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	8252	71	None	-61	12	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	8252	71	None	-61	12	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	8252	71	None	-61	12	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	8252	71	None	-61	12	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		448537	167029	89	None	-33	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	167029	89	None	-33	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		1547484	7727	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	7727	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	7727	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	7727	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	7727	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3047788	84971	15	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL2105148	84971	15	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		1212	8443	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		204	8443	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		3372	8443	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL726	8443	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00623	8443	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		1224	8214	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	8214	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	8214	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	8214	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	8214	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	8214	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-26	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-26	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-26	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-26	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-26	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		2585	7590	103	None	-28	22	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	7590	103	None	-28	22	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	7590	103	None	-28	22	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	7590	103	None	-28	22	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	7590	103	None	-28	22	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		1574	9093	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		5359272	9093	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		7595	9093	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		CHEMBL592	9093	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		DB00854	9093	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		242	7258	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		3678	101567	57	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL253371	101567	57	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		3002977	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		803	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		806	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201187	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL256907	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL584744	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		DB04835	9238	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		441383	27105	57	None	-2	17	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1306	27105	57	None	-2	17	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		193962	110570	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		CHEMBL308954	110570	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		23497	29664	38	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	3	3	5	0.1	COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
		CHEMBL1328898	29664	38	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	3	3	5	0.1	COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
		11154555	7587	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5037	7587	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		7671	7587	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL2028019	7587	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL3085826	7587	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB06016	7587	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		2107	9829	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		4747	9829	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		9216	9829	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL251940	9829	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB01608	9829	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2580	85170	18	None	-	2	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL2110775	85170	18	None	-	2	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		2600	10551	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	10551	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	10551	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	10551	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	10551	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		1599	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3955	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7215	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL841	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00836	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3280	55223	28	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL1555736	55223	28	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		5440	35497	37	None	-	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	35497	37	None	-	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		72287	67835	38	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1764	67835	38	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		5210	40112	48	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		CHEMBL1200765	40112	48	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		CHEMBL1419	40112	48	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		213046	9164	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	9164	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	9164	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	9164	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	9164	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		3601	21275	9	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201349	21275	9	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		115368	9830	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2112	9830	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		7556	9830	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1472975	9830	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		DB08922	9830	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2148	10662	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		2150	10662	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		2784	10662	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		5610	10662	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		CHEMBL11608	10662	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		DB08841	10662	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		11079	9510	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		3369	9510	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		4436	9510	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		5509	9510	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL761	9510	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB06711	9510	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		2162	48288	100	None	1	6	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1491	48288	100	None	1	6	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		2146	9874	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	9874	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	9874	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	9874	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	9874	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		11434515	7049	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		11519741	7049	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		4484	7049	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		7449	7049	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL1194325	7049	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		DB08897	7049	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		2520	210787	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	210787	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	210787	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		2337	10030	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		2520	210787	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	210787	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	210787	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		1531	9046	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		3869	9046	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		7207	9046	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		CHEMBL429	9046	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		DB00598	9046	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		135398745	9688	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	9688	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	9688	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	9688	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		60663	182448	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1421212	182448	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1534525	182448	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL45816	182448	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		3598	194600	76	None	-2	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL496	194600	76	None	-2	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		228	7233	28	None	-5	23	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		33	7233	28	None	-5	23	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		6005	7233	28	None	-5	23	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		CHEMBL53	7233	28	None	-5	23	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		DB00714	7233	28	None	-5	23	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		2406	107180	89	None	-16	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		CHEMBL290106	107180	89	None	-16	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		135412795	51525	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
		CHEMBL1521495	51525	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
		3166	176199	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL442444	176199	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		134	9292	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	9292	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	9292	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	9292	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	9292	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		2028	9753	80	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		359	9753	80	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		4634	9753	80	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		CHEMBL1231	9753	80	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		DB01062	9753	80	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		124087	8171	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	8171	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	8171	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	8171	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	8171	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		2343	21226	57	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
		CHEMBL1201039	21226	57	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
		82146	11302	113	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		CHEMBL1023	11302	113	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		1027	8357	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3241	8357	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		7176	8357	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL1106	8357	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB00751	8357	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		2200	26975	61	None	-	2	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1256819	26975	61	None	-	2	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1305	26975	61	None	-	2	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		3675	14506	68	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1089	14506	68	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
		1712	9270	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4078	9270	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		7227	9270	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		CHEMBL1088	9270	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		DB00933	9270	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		1753	9282	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		483	9282	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		6082	9282	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		CHEMBL524	9282	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		DB00723	9282	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		3157	8252	71	None	-61	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	8252	71	None	-61	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	8252	71	None	-61	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	8252	71	None	-61	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	8252	71	None	-61	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		2473	169962	47	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
		CHEMBL418134	169962	47	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
		2805	168669	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL415087	168669	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2303	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		4946	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		564	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		63	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		91536	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		CHEMBL27	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		CHEMBL452861	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		DB00571	9961	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		2966	65923	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	175	0	2	1	0.9	N=C(N)N1CCc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1593558	65923	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	175	0	2	1	0.9	N=C(N)N1CCc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL169901	65923	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	175	0	2	1	0.9	N=C(N)N1CCc2ccccc2C1	10.1038/s41467-023-40064-9
		2286	9957	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	9957	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	9957	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	9957	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	9957	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL5291995	201315	0	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		4418	40996	85	None	-	7	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		CHEMBL142635	40996	85	None	-	7	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		3584	10549	64	None	-251	14	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	10549	64	None	-251	14	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	10549	64	None	-251	14	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	10549	64	None	-251	14	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	10549	64	None	-251	14	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		2200	26975	61	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1256819	26975	61	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1305	26975	61	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		180	7189	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL4743867	220812	14	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		6237	93579	46	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		CHEMBL232201	93579	46	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		1588	9105	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		28864	9105	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		43	9105	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL157138	9105	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB00589	9105	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		10531	8202	21	None	-5	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	8202	21	None	-5	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	8202	21	None	-5	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	8202	21	None	-5	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	8202	21	None	-5	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		102	10899	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	10899	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	10899	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	10899	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	10899	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3658	10879	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		517	10879	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		5709	10879	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL312448	10879	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		DB06694	10879	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		119584	9373	102	None	-2	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		1848	9373	102	None	-2	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		242	9373	102	None	-2	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		CHEMBL60889	9373	102	None	-2	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		DB11675	9373	102	None	-2	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		2803	7742	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		516	7742	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		704	7742	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		CHEMBL134	7742	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		DB00575	7742	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		2342	7386	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		331	7386	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		7124	7386	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		CHEMBL1201250	7386	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		DB00767	7386	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		2762	10635	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	10635	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	10635	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	10635	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	10635	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		135	9310	43	None	-4	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-4	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-4	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-4	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-4	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		135409453	10545	41	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	10545	41	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	10545	41	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		2710	91083	31	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL22150	91083	31	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		62867	9903	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		7557	9903	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL398880	9903	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01621	9903	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2865	10915	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		2726	7706	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	7706	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	7706	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	7706	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	7706	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		214	10632	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	10632	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	10632	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	10632	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	10632	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	10632	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		12488	8438	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		941361	8438	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		CHEMBL30008	8438	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		DB04841	8438	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		2389	10104	118	None	-77	66	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	10104	118	None	-77	66	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	10104	118	None	-77	66	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	10104	118	None	-77	66	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	10104	118	None	-77	66	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		16351	109507	47	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	109507	47	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		6726	8063	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7151	8063	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		749	8063	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL648	8063	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB01176	8063	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		68712	107114	60	None	-1	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
		CHEMBL289480	107114	60	None	-1	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
		3950	196287	109	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL514	196287	109	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL3039583	217728	0	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		121515	205878	63	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL588934	205878	63	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		2398	7741	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	7741	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	7741	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	7741	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	7741	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		3033538	8101	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		7155	8101	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		781	8101	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1201216	8101	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		DB00298	8101	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL508338	195745	0	None	-6	6	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		65863	21237	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1201196	21237	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		135398745	9688	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	9688	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	9688	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	9688	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		1816	9318	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		4205	9318	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		7241	9318	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		CHEMBL654	9318	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		DB00370	9318	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		1548955	95356	20	None	-1	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2800	95356	20	None	-1	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2355051	95356	20	None	-1	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		3547	148151	71	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL38380	148151	71	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL541388	148151	71	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		4735	201894	96	None	-9	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL361506	201894	96	None	-9	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL55	201894	96	None	-9	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		12555	24733	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL12610	24733	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		6077	157477	31	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	157477	31	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		4822	51806	47	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL152408	51806	47	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		34040	34858	72	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		CHEMBL1372950	34858	72	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		4098	39279	30	None	-13	11	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1255739	39279	30	None	-13	11	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1411979	39279	30	None	-13	11	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		16362	9899	71	None	-501	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	9899	71	None	-501	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	9899	71	None	-501	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	9899	71	None	-501	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	9899	71	None	-501	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		9822750	85184	65	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL2111097	85184	65	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		2142	9870	58	None	-2	37	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4920903	9870	58	None	-2	37	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		502	9870	58	None	-2	37	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		5775	9870	58	None	-2	37	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL597	9870	58	None	-2	37	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		DB00692	9870	58	None	-2	37	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		3783	20777	23	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL1197051	20777	23	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		7029	20441	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	5	0	2	2.6	CCN(CC)C(C)C(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1194666	20441	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	5	0	2	2.6	CCN(CC)C(C)C(=O)c1ccccc1	10.1038/s41467-023-40064-9
		71897	85023	19	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		CHEMBL2106537	85023	19	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		2142	9870	58	None	-2	37	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4920903	9870	58	None	-2	37	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		502	9870	58	None	-2	37	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		5775	9870	58	None	-2	37	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL597	9870	58	None	-2	37	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		DB00692	9870	58	None	-2	37	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4209	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		2993	121470	24	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL121663	121470	24	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL333826	121470	24	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		2803	7742	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		516	7742	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		704	7742	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		CHEMBL134	7742	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		DB00575	7742	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		2389	10104	118	None	-77	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	10104	118	None	-77	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	10104	118	None	-77	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	10104	118	None	-77	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	10104	118	None	-77	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		4167	21272	43	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	21272	43	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		4034	62596	55	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	62596	55	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		60860	212418	30	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL1615777	212418	30	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL818	212418	30	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		2446	161432	57	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL399510	161432	57	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		277	8083	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2913	8083	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		765	8083	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL516	8083	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB00434	8083	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2284	9956	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	9956	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	9956	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	9956	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	9956	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		3658	10879	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		517	10879	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		5709	10879	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL312448	10879	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		DB06694	10879	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		1960	9632	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		439260	9632	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		505	9632	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		CHEMBL1437	9632	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		DB00368	9632	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		102	10899	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	10899	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	10899	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	10899	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	10899	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		68802	116812	37	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		CHEMBL32350	116812	37	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		4209	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	9937	75	None	-1380	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		3158	63041	27	None	-3467	20	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	63041	27	None	-3467	20	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		11976	7707	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	7707	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	7707	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	7707	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		681	8247	72	None	-	38	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		940	8247	72	None	-	38	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		947	8247	72	None	-	38	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL59	8247	72	None	-	38	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		DB00988	8247	72	None	-	38	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		31101	7516	40	None	-10	35	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	7516	40	None	-10	35	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	7516	40	None	-10	35	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	7516	40	None	-10	35	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	7516	40	None	-10	35	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		22530	62904	58	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1600878	62904	58	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1625607	62904	58	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		2510	10034	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		3034034	10034	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		4523	10034	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		CHEMBL170	10034	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		DB00468	10034	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		2181	9902	46	None	-58	34	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		4830	9902	46	None	-58	34	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		92	9902	46	None	-58	34	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL440294	9902	46	None	-58	34	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		DB09286	9902	46	None	-58	34	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		2391	214232	92	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	361	5	0	5	4.1	CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1	10.1038/s41467-023-40064-9
		CHEMBL942	214232	92	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	361	5	0	5	4.1	CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1	10.1038/s41467-023-40064-9
		2337	10030	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		22323	22071	32	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9571037	22071	32	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1213553	22071	32	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		10180	105645	47	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL279014	105645	47	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		2220	9908	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		27400	9908	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		93	9908	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL294951	9908	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB06153	9908	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		1712095	202171	30	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL551978	202171	30	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		3336	101776	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1405922	101776	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL254832	101776	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3158	63041	27	None	-3467	20	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	63041	27	None	-3467	20	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		5489013	64179	32	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		CHEMBL1651913	64179	32	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		2105	9828	37	None	-13	32	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	9828	37	None	-13	32	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	9828	37	None	-13	32	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	9828	37	None	-13	32	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	9828	37	None	-13	32	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		3294	8787	111	None	-47	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	8787	111	None	-47	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	8787	111	None	-47	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	8787	111	None	-47	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	8787	111	None	-47	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		5328940	106992	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	106992	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		2683	109665	25	None	-12	16	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL305906	109665	25	None	-12	16	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL334255	109665	25	None	-12	16	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		4151	10379	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		493	10379	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		5312125	10379	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL24778	10379	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		DB06207	10379	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		2247	7293	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	7293	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	7293	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	7293	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	7293	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2351	10059	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		2820	10059	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		5035	10059	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		CHEMBL81	10059	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		DB00481	10059	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		2146	9874	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	9874	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	9874	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	9874	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	9874	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		443869	84916	45	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2103761	84916	45	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		2605	10555	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		36920	10555	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		571	10555	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL434200	10555	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		DB13775	10555	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		5419	24832	57	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL1200413	24832	57	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL1266	24832	57	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
		8249	66179	65	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1528839	66179	65	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL170988	66179	65	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		191	7191	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	7191	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	7191	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	7191	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	7191	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2286	9957	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	9957	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	9957	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	9957	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	9957	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5354	162435	21	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL404849	162435	21	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		1086	8371	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		3290	8371	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		7181	8371	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		CHEMBL1206	8371	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		DB00392	8371	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		4829	206735	108	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	1	5	3.2	CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1	10.1038/s41467-023-40064-9
		CHEMBL595	206735	108	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	1	5	3.2	CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1	10.1038/s41467-023-40064-9
		1227	9267	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2331	9267	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		3957	9267	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		4992	9267	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL511	9267	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		DB06691	9267	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		37	7565	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	7565	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	7565	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	7565	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	7565	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		3584	10549	64	None	-251	14	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	10549	64	None	-251	14	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	10549	64	None	-251	14	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	10549	64	None	-251	14	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	10549	64	None	-251	14	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7099	202301	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		CHEMBL55400	202301	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		1782	9296	84	None	-5	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		241	9296	84	None	-5	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		4168	9296	84	None	-5	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		CHEMBL86	9296	84	None	-5	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		DB01233	9296	84	None	-5	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		5311507	201594	41	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL53904	201594	41	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		26987	7736	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	7736	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	7736	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	7736	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	7736	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		3103	48432	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1492	48432	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		31101	7516	40	None	-10	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	7516	40	None	-10	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	7516	40	None	-10	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	7516	40	None	-10	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	7516	40	None	-10	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		135	9310	43	None	-4	56	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-4	56	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-4	56	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-4	56	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-4	56	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		40	8329	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		77993	8329	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		995	8329	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1510	8329	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		DB00216	8329	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		1577	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2537	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5355	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5501	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		643497	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		688272	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		958	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		960	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL196677	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL26	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL267044	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB00391	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB16021	10475	110	None	-3	20	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		212	10578	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	10578	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	10578	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	10578	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	10578	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		5328940	106992	107	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	106992	107	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		54477	91428	36	None	-	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
		CHEMBL22242	91428	36	None	-	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
		5353853	24758	47	None	-16	15	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9556529	24758	47	None	-16	15	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1262	24758	47	None	-16	15	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		43082	67057	37	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1742452	67057	37	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		129211	10521	78	None	-120	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		2562	10521	78	None	-120	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		488	10521	78	None	-120	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		CHEMBL836	10521	78	None	-120	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		DB00706	10521	78	None	-120	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		3952	8669	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5353646	8669	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5443	8669	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5702063	8669	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL1331786	8669	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL420	8669	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		11079	9510	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		3369	9510	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		4436	9510	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		5509	9510	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL761	9510	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB06711	9510	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		3344	205097	57	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		CHEMBL576127	205097	57	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		6075	156887	42	None	-11	16	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL395110	156887	42	None	-11	16	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		73417116	161210	0	None	-	1	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL3989843	161210	0	None	-	1	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1038/s41467-023-40064-9
		65772	67177	8	None	-	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL174984	67177	8	None	-	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		4209	9937	75	None	-1380	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	9937	75	None	-1380	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	9937	75	None	-1380	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	9937	75	None	-1380	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	9937	75	None	-1380	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	9937	75	None	-1380	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		2444	21250	26	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201245	21250	26	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		213	10625	55	None	-10	43	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2717	10625	55	None	-10	43	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		5533	10625	55	None	-10	43	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL621	10625	55	None	-10	43	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00656	10625	55	None	-10	43	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		27901	84982	22	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2105458	84982	22	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		114948	67071	14	None	-	3	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		CHEMBL1743263	67071	14	None	-	3	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		1353	8692	93	None	-190	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-190	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-190	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-190	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-190	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		1028	7079	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		139148732	7079	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		479	7079	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		5816	7079	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		CHEMBL679	7079	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		DB00668	7079	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		9887712	174247	104	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	6	4	6	1.8	CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL429910	174247	104	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	6	4	6	1.8	CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1	10.1038/s41467-023-40064-9
		133	9274	52	None	-23	43	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		1723	9274	52	None	-23	43	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		28693	9274	52	None	-23	43	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL19215	9274	52	None	-23	43	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		DB13520	9274	52	None	-23	43	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		54758501	145845	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		CHEMBL3786343	145845	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		2146	9874	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	9874	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	9874	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	9874	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	9874	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		2865	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		1613	9127	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	9127	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	9127	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	9127	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	9127	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		68818	85043	28	None	-	0	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	217	1	2	3	2.2	c1ccc2c(SC3=NCCN3)c[nH]c2c1	10.1038/s41467-023-40064-9
		CHEMBL2107015	85043	28	None	-	0	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	217	1	2	3	2.2	c1ccc2c(SC3=NCCN3)c[nH]c2c1	10.1038/s41467-023-40064-9
		10219	195575	37	None	-1	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL493439	195575	37	None	-1	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL50588	195575	37	None	-1	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		2865	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		2749	7132	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5574	7132	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7237	7132	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL829	7132	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01246	7132	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		135409453	10545	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	10545	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	10545	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		5568	204279	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		66069	204279	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL1201102	204279	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL570	204279	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		4567	16720	34	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL114655	16720	34	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		5329102	201505	86	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	201505	86	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		9419	42696	35	None	-	6	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1442422	42696	35	None	-	6	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		1224	8214	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	8214	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	8214	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	8214	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	8214	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	8214	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		1830	9368	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		207	9368	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		23897	9368	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL460	9368	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		DB01618	9368	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		9417	140290	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	140290	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	140290	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		37464	25993	26	None	-	4	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1290	25993	26	None	-	4	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		4601	213526	35	None	-2	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201023	213526	35	None	-2	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL900	213526	35	None	-2	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		104870	105656	47	None	-2	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		5374	105656	47	None	-2	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		CHEMBL279085	105656	47	None	-2	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		5205	84962	58	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL2104895	84962	58	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		168295528	199810	0	None	-11	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	199810	0	None	-11	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	199810	0	None	-11	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294767	199798	0	None	-11	20	Human	5.3	pEC50	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-11	20	Human	5.3	pEC50	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-11	20	Human	5.3	pEC50	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		102	10899	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		3659	10899	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		8969	10899	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		CHEMBL15245	10899	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		DB01392	10899	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		168290235	199747	0	None	-40	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	199747	0	None	-40	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	199747	0	None	-40	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		164612037	192156	0	None	-11	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	192156	0	None	-11	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		44377036	126934	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL351483	126934	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376984	62997	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	485	3	0	5	4.0	Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162682	62997	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	485	3	0	5	4.0	Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376923	63201	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL163190	63201	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		22120332	62819	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	389	4	0	6	3.4	COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12	10.1016/s0960-894x(99)00591-0
		CHEMBL162490	62819	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	389	4	0	6	3.4	COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12	10.1016/s0960-894x(99)00591-0
		1588	9105	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	9105	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	9105	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	9105	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	9105	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		44376954	62514	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	387	3	0	5	4.0	Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		CHEMBL162232	62514	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	387	3	0	5	4.0	Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		22120322	62695	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1	10.1016/s0960-894x(99)00591-0
		CHEMBL162370	62695	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1	10.1016/s0960-894x(99)00591-0
		44377200	64194	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	437	3	0	5	4.1	Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165350	64194	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	437	3	0	5	4.1	Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		3294	8787	111	None	-	44	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		71360	8787	111	None	-	44	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		87	8787	111	None	-	44	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		CHEMBL14376	8787	111	None	-	44	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		DB04946	8787	111	None	-	44	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		44376958	64253	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		CHEMBL165796	64253	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		3682	196216	12	None	-	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human adrenergic alpha2 receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2 receptor by radioligand displacement assay	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.bmc.2013.03.016
		CHEMBL1256784	196216	12	None	-	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human adrenergic alpha2 receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2 receptor by radioligand displacement assay	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.bmc.2013.03.016
		CHEMBL513389	196216	12	None	-	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human adrenergic alpha2 receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2 receptor by radioligand displacement assay	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.bmc.2013.03.016
		3045401	62833	32	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	359	3	0	5	3.4	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162501	62833	32	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	359	3	0	5	3.4	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376993	63258	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	427	3	0	5	4.7	Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL163247	63258	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	427	3	0	5	4.7	Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44377035	126908	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL351200	126908	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376900	63042	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	1	6	3.1	Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162826	63042	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	1	6	3.1	Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44377007	63922	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL164612	63922	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1	10.1016/s0960-894x(99)00591-0
		10531	8202	21	None	-5	24	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	8202	21	None	-5	24	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	8202	21	None	-5	24	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	8202	21	None	-5	24	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	8202	21	None	-5	24	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		44376927	62411	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	461	3	0	5	5.0	Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162147	62411	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	461	3	0	5	5.0	Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		9951544	64150	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	0	5	3.8	Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165181	64150	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	0	5	3.8	Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		107715	207724	22	None	-6	20	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	207724	22	None	-6	20	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	207724	22	None	-6	20	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		44376936	64248	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	4	0	5	3.7	Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165776	64248	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	4	0	5	3.7	Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		10095594	19140	0	None	-	0	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1185501	19140	0	None	-	0	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL417550	19140	0	None	-	0	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10342423	106245	0	None	-	1	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	426	11	1	5	3.9	CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL28312	106245	0	None	-	1	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	426	11	1	5	3.9	CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL48925	106245	0	None	-	1	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	426	11	1	5	3.9	CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		44401591	75672	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	8	3	7	5.1	Nc1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL192266	75672	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	8	3	7	5.1	Nc1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		1220	6975	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		31	6975	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		7	6975	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		CHEMBL56	6975	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		10070029	172196	0	None	-	1	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL423841	172196	0	None	-	1	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54089	172196	0	None	-	1	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		59271992	124826	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of alpha-adrenoceptor 2A (unknown origin)Inhibition of alpha-adrenoceptor 2A (unknown origin)	ChEMBL	513	13	2	7	3.5	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccccc2)C(C)C)ccc1OC	10.1016/j.bmcl.2015.02.040
		CHEMBL3403995	124826	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of alpha-adrenoceptor 2A (unknown origin)Inhibition of alpha-adrenoceptor 2A (unknown origin)	ChEMBL	513	13	2	7	3.5	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccccc2)C(C)C)ccc1OC	10.1016/j.bmcl.2015.02.040
		2477	7532	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		36	7532	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		437	7532	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL49	7532	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		DB00490	7532	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		121852	16938	7	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	16938	7	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	16938	7	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9981024	102872	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	102872	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	102872	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10040815	103835	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	306	7	1	4	1.8	CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL264027	103835	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	306	7	1	4	1.8	CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26715	103835	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	306	7	1	4	1.8	CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10047322	103915	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL26783	103915	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL50993	103915	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		10364722	105861	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	105861	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	105861	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10338595	169278	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL416747	169278	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10265863	200103	0	None	-	0	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		CHEMBL52438	200103	0	None	-	0	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		14450375	171649	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	233	0	1	3	2.3	Cc1ccc(O)c2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		CHEMBL422024	171649	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	233	0	1	3	2.3	Cc1ccc(O)c2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		1305	7299	14	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		9934033	7299	14	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL182150	7299	14	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		2585	7590	103	None	-28	22	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	7590	103	None	-28	22	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	7590	103	None	-28	22	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	7590	103	None	-28	22	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	7590	103	None	-28	22	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		25208878	187842	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	406	6	1	3	4.9	CC1=C(CCN(C)C)c2cc(S(=O)(=O)Nc3cccc4ccccc34)ccc2C1	10.1021/jm8009469
		CHEMBL475969	187842	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	406	6	1	3	4.9	CC1=C(CCN(C)C)c2cc(S(=O)(=O)Nc3cccc4ccccc34)ccc2C1	10.1021/jm8009469
		44390778	71053	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	403	5	2	5	4.2	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		CHEMBL180962	71053	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	403	5	2	5	4.2	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		11284878	77216	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL194602	77216	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		9885114	126382	5	None	-95	12	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		CHEMBL346389	126382	5	None	-95	12	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		CHEMBL5070958	221028	3	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		4098	39279	30	None	-13	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	39279	30	None	-13	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	39279	30	None	-13	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		2812	11551	101	None	-32	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-32	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		16718919	206560	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	462	4	1	6	4.5	CC1=C(C2CCCN(C)C2)c2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1	10.1016/j.bmc.2009.08.006
		CHEMBL593889	206560	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	462	4	1	6	4.5	CC1=C(C2CCCN(C)C2)c2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1	10.1016/j.bmc.2009.08.006
		3561	25849	39	None	-1	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	25849	39	None	-1	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		23027211	204029	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL568400	204029	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		11284878	71117	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(N[C@H]2CC[C@@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181217	71117	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(N[C@H]2CC[C@@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44390713	130473	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL362193	130473	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44401626	78129	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	558	7	2	6	5.2	O=S(=O)(NCC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL195810	78129	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	558	7	2	6	5.2	O=S(=O)(NCC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL5076569	221228	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2cccnc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		191	7191	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	7191	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	7191	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	7191	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	7191	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		100	10577	58	None	-33	54	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	10577	58	None	-33	54	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	10577	58	None	-33	54	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	10577	58	None	-33	54	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	10577	58	None	-33	54	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		3158	63041	27	None	-3467	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	63041	27	None	-3467	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		1343	8670	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		3519	8670	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		522	8670	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL862	8670	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		DB01018	8670	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		4735	201894	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	201894	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	201894	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		3584	10549	64	None	-251	14	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		5401	10549	64	None	-251	14	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		7302	10549	64	None	-251	14	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		CHEMBL611	10549	64	None	-251	14	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		DB01162	10549	64	None	-251	14	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		44401552	172685	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	572	8	2	6	5.5	O=S(=O)(NCC1CCC(CNc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL425012	172685	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	572	8	2	6	5.5	O=S(=O)(NCC1CCC(CNc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		448537	167029	89	None	-33	25	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	167029	89	None	-33	25	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		2398	7741	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	7741	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	7741	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	7741	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	7741	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		15730	77893	80	None	-2	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	77893	80	None	-2	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		6075	156887	42	None	-11	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	156887	42	None	-11	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		31101	7516	40	None	-10	35	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	7516	40	None	-10	35	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	7516	40	None	-10	35	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	7516	40	None	-10	35	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	7516	40	None	-10	35	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		44390730	71091	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	414	5	2	6	3.7	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C#N)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181099	71091	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	414	5	2	6	3.7	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C#N)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44390742	130068	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL361442	130068	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14450355	126746	0	None	-	0	Bovine	6.8	pIC50	=	6.8	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	259	3	0	3	3.0	CCCN1CCC=C2c3c(OC)cccc3OCC21	10.1021/jm00123a039
		CHEMBL349824	126746	0	None	-	0	Bovine	6.8	pIC50	=	6.8	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	259	3	0	3	3.0	CCCN1CCC=C2c3c(OC)cccc3OCC21	10.1021/jm00123a039
		6726	8063	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	8063	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	8063	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	8063	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	8063	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		150	9287	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	9287	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	9287	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	9287	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	9287	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		23027411	205299	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577912	205299	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		134	9292	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	9292	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	9292	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	9292	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	9292	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		44190762	183659	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from adrenergic alpha2A receptorDisplacement of radioligand from adrenergic alpha2A receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		CHEMBL461571	183659	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from adrenergic alpha2A receptorDisplacement of radioligand from adrenergic alpha2A receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		2750	210840	76	None	-3	12	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-3	12	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		2351	10059	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	10059	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	10059	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	10059	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	10059	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		1042	8362	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	8362	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	8362	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	8362	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	8362	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		2274	9947	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	9947	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	9947	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	9947	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	9947	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44390733	69268	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	537	7	2	6	5.9	CN(C)c1nc(NC2CCC(NCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL178084	69268	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	537	7	2	6	5.9	CN(C)c1nc(NC2CCC(NCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		11342160	129713	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360671	129713	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		11342160	129713	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL360671	129713	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		23027035	205326	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		CHEMBL578170	205326	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		240	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		2769	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		44279790	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		660	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL1729	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL560739	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		DB00604	7731	43	None	-12	25	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		26757	214757	31	None	-1	2	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		CHEMBL972	214757	31	None	-1	2	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		196129	74573	17	None	-85	15	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	74573	17	None	-85	15	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		4011	89183	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	89183	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		26987	7736	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	7736	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	7736	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	7736	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	7736	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		28417	46813	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	46813	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		16215415	194111	1	None	3	5	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		CHEMBL493091	194111	1	None	3	5	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		10331436	7112	10	None	-	6	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		160	7112	10	None	-	6	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		CHEMBL133455	7112	10	None	-	6	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		45482789	205704	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		CHEMBL584554	205704	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		1016	10519	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		3823	56995	42	None	-40	11	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	56995	42	None	-40	11	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	56995	42	None	-40	11	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		2803	7742	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		516	7742	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		704	7742	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		CHEMBL134	7742	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		DB00575	7742	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		1043	8363	14	None	-8	29	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	8363	14	None	-8	29	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	8363	14	None	-8	29	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	8363	14	None	-8	29	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	8363	14	None	-8	29	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		44376975	62760	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	435	5	0	5	4.6	O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12	10.1016/s0960-894x(99)00591-0
		CHEMBL162436	62760	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	435	5	0	5	4.6	O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12	10.1016/s0960-894x(99)00591-0
		121852	16938	7	None	-	1	Bovine	7.7	pIC50	=	7.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	16938	7	None	-	1	Bovine	7.7	pIC50	=	7.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	16938	7	None	-	1	Bovine	7.7	pIC50	=	7.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		135	9310	43	None	-4	56	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		1796	9310	43	None	-4	56	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		4184	9310	43	None	-4	56	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		CHEMBL6437	9310	43	None	-4	56	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		DB06148	9310	43	None	-4	56	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		45485061	205533	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	489	5	2	5	5.0	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL583014	205533	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	489	5	2	5	5.0	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		44390787	129343	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	443	5	2	5	4.3	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)c(F)c3F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360159	129343	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	443	5	2	5	4.3	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)c(F)c3F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		9981024	102872	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	102872	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	102872	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		131001	105769	7	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27995	105769	7	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		10321248	106202	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL28287	106202	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50722	106202	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10251673	106266	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283207	106266	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52396	106266	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9978353	18025	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL1178987	18025	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL52785	18025	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		10105405	102807	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	5	0	2	3.1	CCCN(CCC)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL25984	102807	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	5	0	2	3.1	CCCN(CCC)C1COc2ccccc2C1	10.1021/jm00038a007
		11743327	105478	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27763	105478	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		1577	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		2537	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5355	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5501	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		643497	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		688272	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		958	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		960	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL196677	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL26	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL267044	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB00391	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB16021	10475	110	None	-3	20	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		657255	205863	34	None	-10	15	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	205863	34	None	-10	15	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		1210	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	7705	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		5467	212707	43	None	-6	5	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		CHEMBL84158	212707	43	None	-6	5	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		14151683	63311	0	None	-	0	Bovine	6.7	pIC50	=	6.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	2	0	2	2.9	CCCN1CCC=C2c3ccccc3OCC21	10.1021/jm00123a039
		CHEMBL163803	63311	0	None	-	0	Bovine	6.7	pIC50	=	6.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	2	0	2	2.9	CCCN1CCC=C2c3ccccc3OCC21	10.1021/jm00123a039
		44401616	76808	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NCC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL193970	76808	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NCC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		45484995	205298	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577904	205298	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		5897	111988	80	None	-7	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		CHEMBL311469	111988	80	None	-7	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		1212	8443	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		4601	213526	35	None	-2	17	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	213526	35	None	-2	17	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	213526	35	None	-2	17	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		1530	8963	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		237	211644	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	211644	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	211644	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	211644	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		124	9755	47	None	-4	32	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2032	9755	47	None	-4	32	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		4636	9755	47	None	-4	32	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL762	9755	47	None	-4	32	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		DB00935	9755	47	None	-4	32	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL5083458	221642	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		c1cnc2c(c1)CN[C@@H](CN(CCCCNC1COC1)[C@H]1CCCc3cccnc31)C2	10.1021/acs.jmedchem.1c01564
		25014630	90314	1	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		CHEMBL2203713	90314	1	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		2683	109665	25	None	-12	16	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	109665	25	None	-12	16	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	109665	25	None	-12	16	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		14151624	62579	0	None	-	0	Bovine	6.6	pIC50	=	6.6	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3ccc(O)cc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162282	62579	0	None	-	0	Bovine	6.6	pIC50	=	6.6	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3ccc(O)cc3OC[C@H]21	10.1021/jm00123a039
		2337	10030	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	10030	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	10030	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	10030	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	10030	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		1305	7299	14	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2005.05.121
		9934033	7299	14	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2005.05.121
		CHEMBL182150	7299	14	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2005.05.121
		4209	9937	75	None	-1380	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		4893	9937	75	None	-1380	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		503	9937	75	None	-1380	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		5385	9937	75	None	-1380	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL2	9937	75	None	-1380	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		DB00457	9937	75	None	-1380	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		2105	9828	37	None	-13	32	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	9828	37	None	-13	32	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	9828	37	None	-13	32	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	9828	37	None	-13	32	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	9828	37	None	-13	32	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		1782	9296	84	None	-5	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		241	9296	84	None	-5	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		4168	9296	84	None	-5	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		CHEMBL86	9296	84	None	-5	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		DB01233	9296	84	None	-5	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		3151	8244	97	None	-99	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	8244	97	None	-99	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	8244	97	None	-99	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	8244	97	None	-99	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	8244	97	None	-99	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		2803	7742	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		516	7742	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		704	7742	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		CHEMBL134	7742	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		DB00575	7742	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		42	8844	57	None	-	18	Bovine	5.6	pIC50	=	5.6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		56971	8844	57	None	-	18	Bovine	5.6	pIC50	=	5.6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL8412	8844	57	None	-	18	Bovine	5.6	pIC50	=	5.6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL5077132	221263	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		CN(CCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21)C1CCOCC1	10.1021/acs.jmedchem.1c01564
		277	8083	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	8083	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	8083	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	8083	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	8083	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		24180125	102431	71	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		CHEMBL257991	102431	71	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		68617	212306	62	None	-3	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	212306	62	None	-3	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	212306	62	None	-3	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		3168	16034	92	None	-123	22	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	16034	92	None	-123	22	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		1227	9267	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	9267	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	9267	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	9267	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	9267	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	9267	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2435	7509	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		395	7509	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		520	7509	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		5386	7509	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		CHEMBL844	7509	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		DB00484	7509	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		44376845	62319	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	419	5	0	7	3.4	COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC	10.1016/s0960-894x(99)00591-0
		CHEMBL162058	62319	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	419	5	0	7	3.4	COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC	10.1016/s0960-894x(99)00591-0
		102	10899	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		3659	10899	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		8969	10899	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		CHEMBL15245	10899	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		DB01392	10899	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		44377006	64237	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165677	64237	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1	10.1016/s0960-894x(99)00591-0
		10014217	106524	0	None	-	1	Bovine	5.5	pIC50	=	5.5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	2	0	3	2.1	COc1cccc2c1CC(N1CCCC1)CO2	10.1021/jm00038a007
		CHEMBL285010	106524	0	None	-	1	Bovine	5.5	pIC50	=	5.5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	2	0	3	2.1	COc1cccc2c1CC(N1CCCC1)CO2	10.1021/jm00038a007
		10019102	39294	3	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	323	3	0	3	3.7	COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1	10.1021/jm010992z
		CHEMBL141209	39294	3	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	323	3	0	3	3.7	COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1	10.1021/jm010992z
		44390385	129294	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	9	2	6	6.4	CN(C)c1nc(NCC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360117	129294	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	9	2	6	6.4	CN(C)c1nc(NCC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		15987265	203666	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL566075	203666	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		10915140	36247	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	351	5	0	3	4.2	COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1	10.1021/jm010992z
		CHEMBL138458	36247	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	351	5	0	3	4.2	COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1	10.1021/jm010992z
		2335	18620	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	18620	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	18620	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	18620	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		176	7186	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		44596863	205706	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	367	6	1	6	2.3	C=Cc1c(C)nn(CCCN2CCN(c3ccc(C)cc3)CC2)c(=O)c1N	10.1021/jm900458r
		CHEMBL584606	205706	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	367	6	1	6	2.3	C=Cc1c(C)nn(CCCN2CCN(c3ccc(C)cc3)CC2)c(=O)c1N	10.1021/jm900458r
		2284	9956	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	9956	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	9956	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	9956	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	9956	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		44390369	71384	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	629	9	1	7	5.9	CN(C)c1nc(NCC2CCC(CN(C)S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181727	71384	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	629	9	1	7	5.9	CN(C)c1nc(NCC2CCC(CN(C)S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		3038525	20321	114	None	-2	3	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		CHEMBL119385	20321	114	None	-2	3	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		44240743	13529	15	None	-	1	Human	4.5	pIC50	=	4.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	370	7	2	3	4.3	O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1	10.1021/jm901692q
		CHEMBL1083787	13529	15	None	-	1	Human	4.5	pIC50	=	4.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	370	7	2	3	4.3	O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1	10.1021/jm901692q
		180	7189	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	7189	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	7189	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	7189	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	7189	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2726	7706	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL1350036	74572	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1909062	74572	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		9807658	71320	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	8	2	6	6.1	CN(C)c1nc(NC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181466	71320	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	8	2	6	6.1	CN(C)c1nc(NC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14151619	62189	0	None	-	0	Bovine	6.4	pIC50	=	6.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3c(O)cccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL161947	62189	0	None	-	0	Bovine	6.4	pIC50	=	6.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3c(O)cccc3OC[C@H]21	10.1021/jm00123a039
		2484	215072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		CHEMBL990	215072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		119584	9373	102	None	-2	6	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		1848	9373	102	None	-2	6	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		242	9373	102	None	-2	6	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL60889	9373	102	None	-2	6	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		DB11675	9373	102	None	-2	6	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		57345320	10604	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acsmedchemlett.8b00030
		9882	10604	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acsmedchemlett.8b00030
		CHEMBL3091687	10604	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acsmedchemlett.8b00030
		57345320	10604	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		9882	10604	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		CHEMBL3091687	10604	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		9904205	212629	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL83658	212629	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		9904205	212629	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83658	212629	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		10219	195575	37	None	-1	5	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL493439	195575	37	None	-1	5	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL50588	195575	37	None	-1	5	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		5472	212597	75	None	-1	3	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL1717	212597	75	None	-1	3	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL833	212597	75	None	-1	3	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		2406	107180	89	None	-16	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	107180	89	None	-16	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		14151652	103415	0	None	-	0	Bovine	7.4	pIC50	=	7.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	1	3	3.1	CCCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		CHEMBL263574	103415	0	None	-	0	Bovine	7.4	pIC50	=	7.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	1	3	3.1	CCCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		10231050	71108	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	6	2	6	5.5	CN(C)c1nc(NC2CCC(NC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181184	71108	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	6	2	6	5.5	CN(C)c1nc(NC2CCC(NC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		1836	9370	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	9370	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	9370	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	9370	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	9370	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		4189	213701	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		10024943	104165	0	None	-	1	Bovine	6.4	pIC50	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26975	104165	0	None	-	1	Bovine	6.4	pIC50	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52485	104165	0	None	-	1	Bovine	6.4	pIC50	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10429859	18814	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL1183429	18814	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL296395	18814	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		10092409	18818	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1183479	18818	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL299561	18818	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10319624	105763	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27991	105763	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL298534	105763	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		3082597	106335	8	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	106335	8	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9975915	106512	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL284912	106512	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10072866	204254	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51561	204254	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL56990	204254	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		5318	22348	49	None	-1	13	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	22348	49	None	-1	13	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	22348	49	None	-1	13	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		5353853	24758	47	None	-16	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	24758	47	None	-16	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	24758	47	None	-16	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		3952	8669	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5353646	8669	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5443	8669	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5702063	8669	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL1331786	8669	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL420	8669	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		135	9310	43	None	-4	56	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	9310	43	None	-4	56	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	9310	43	None	-4	56	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	9310	43	None	-4	56	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	9310	43	None	-4	56	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		10660	21188	58	None	-43	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	21188	58	None	-43	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		6918276	22383	7	None	-16	8	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	22383	7	None	-16	8	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		3198	212292	76	None	-19	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-19	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-19	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		19426635	212372	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL81485	212372	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		44390456	71675	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	9	1	6	6.7	CN(Cc1ccc(Br)cc1OC(F)(F)F)CC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.05.121
		CHEMBL182235	71675	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	9	1	6	6.7	CN(Cc1ccc(Br)cc1OC(F)(F)F)CC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.05.121
		1547484	7727	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	7727	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	7727	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	7727	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	7727	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL1441214	46591	0	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1476898	46591	0	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		44390715	130598	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	5.2	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL362400	130598	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	5.2	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		11204090	76611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(NC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL193771	76611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(NC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		23027527	203571	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL565551	203571	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		10381889	113846	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL315772	113846	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		10381889	113846	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL315772	113846	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		5198	26205	54	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		CHEMBL12948	26205	54	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		2247	7293	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		3117	214620	103	None	-2	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	214620	103	None	-2	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		1353	8692	93	None	-190	85	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	8692	93	None	-190	85	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	8692	93	None	-190	85	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	8692	93	None	-190	85	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	8692	93	None	-190	85	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		44401671	77041	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	1	7	4.9	CN(C)c1nc(NCC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL194173	77041	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	1	7	4.9	CN(C)c1nc(NCC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		9980269	105859	0	None	-	1	Bovine	6.3	pIC50	=	6.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280586	105859	0	None	-	1	Bovine	6.3	pIC50	=	6.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54266	105859	0	None	-	1	Bovine	6.3	pIC50	=	6.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10251234	18017	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	18017	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	18017	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10476735	20503	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1195096	20503	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL553833	20503	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10364722	105861	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	105861	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	105861	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		44318454	212788	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84931	212788	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		14450361	62847	0	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	275	3	0	3	3.4	CCCN1CCC[C@@H]2c3c(OC)cc(C)cc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162510	62847	0	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	275	3	0	3	3.4	CCCN1CCC[C@@H]2c3c(OC)cc(C)cc3OC[C@H]21	10.1021/jm00123a039
		44390752	129774	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	523	6	1	6	5.4	CN(C)c1nc(NC2CCN(Cc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360876	129774	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	523	6	1	6	5.4	CN(C)c1nc(NC2CCN(Cc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL508338	195745	0	None	-6	6	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		11057	182928	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		135398745	9688	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	9688	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	9688	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	9688	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		1201549	7384	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	7384	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	7384	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	7384	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	7384	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	7384	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		3598	194600	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	194600	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		10243700	63057	1	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162955	63057	1	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm00123a039
		11204090	70281	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(N[C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL180003	70281	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(N[C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44401449	77869	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	544	6	2	6	5.0	O=S(=O)(NC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL195346	77869	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	544	6	2	6	5.0	O=S(=O)(NC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		10303307	71250	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	7	2	6	5.8	CN(C)c1nc(NC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181393	71250	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	7	2	6	5.8	CN(C)c1nc(NC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		1549008	212459	85	None	-	1	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		CHEMBL822	212459	85	None	-	1	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		2520	210787	70	None	-6	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL1280	210787	70	None	-6	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL6966	210787	70	None	-6	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		133	9274	52	None	-23	43	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	9274	52	None	-23	43	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	9274	52	None	-23	43	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	9274	52	None	-23	43	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	9274	52	None	-23	43	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		44401508	76596	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	433	10	2	6	3.6	CCCCS(=O)(=O)NCC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.03.052
		CHEMBL193666	76596	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	433	10	2	6	3.6	CCCCS(=O)(=O)NCC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.03.052
		45485062	203947	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		CHEMBL567993	203947	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		12488	8438	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	8438	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	8438	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	8438	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL1200633	215379	3	None	-7	8	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		145949343	169711	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	404	6	2	4	3.9	c1ccc2c(c1)CN[C@@H](CN(CC[C@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2	10.1021/acsmedchemlett.8b00030
		CHEMBL4174290	169711	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	404	6	2	4	3.9	c1ccc2c(c1)CN[C@@H](CN(CC[C@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2	10.1021/acsmedchemlett.8b00030
		2142	9870	58	None	-2	37	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		4920903	9870	58	None	-2	37	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		502	9870	58	None	-2	37	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		5775	9870	58	None	-2	37	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		CHEMBL597	9870	58	None	-2	37	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		DB00692	9870	58	None	-2	37	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		102	10899	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		3659	10899	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		8969	10899	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		CHEMBL15245	10899	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		DB01392	10899	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		73453	36389	24	None	-3	17	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	36389	24	None	-3	17	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		44390710	71363	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	4.9	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C(F)(F)F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181632	71363	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	4.9	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C(F)(F)F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		10252000	105323	0	None	-	1	Bovine	5.2	pIC50	=	5.2	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27650	105323	0	None	-	1	Bovine	5.2	pIC50	=	5.2	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50188	105323	0	None	-	1	Bovine	5.2	pIC50	=	5.2	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		2162	48288	100	None	1	6	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		CHEMBL1491	48288	100	None	1	6	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		CHEMBL5082142	221566	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		c1cnc2c(c1)CN[C@@H](CN(CCCCN1CCOCC1)[C@H]1CCCc3cccnc31)C2	10.1021/acs.jmedchem.1c01564
		10357986	36678	2	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	309	3	0	3	3.9	COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm010992z
		CHEMBL138809	36678	2	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	309	3	0	3	3.9	COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm010992z
		11080	35858	79	None	1	6	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	35858	79	None	1	6	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		44390706	128811	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	467	5	2	5	4.6	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Br)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL359510	128811	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	467	5	2	5	4.6	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Br)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14151702	63120	1	None	-	0	Bovine	6.2	pIC50	=	6.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	245	2	1	3	2.7	CCCN1CCC=C2c3cc(O)ccc3OCC21	10.1021/jm00123a039
		CHEMBL163061	63120	1	None	-	0	Bovine	6.2	pIC50	=	6.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	245	2	1	3	2.7	CCCN1CCC=C2c3cc(O)ccc3OCC21	10.1021/jm00123a039
		6761	74574	19	None	-6	18	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	74574	19	None	-6	18	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		1752	52535	59	None	-2	5	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		CHEMBL153062	52535	59	None	-2	5	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		2286	9957	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	9957	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	9957	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	9957	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	9957	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL1458880	44624	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		9895868	19671	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL1188966	19671	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL537846	19671	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		9895868	76357	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL193438	76357	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		134551	7146	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	7146	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	7146	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	7146	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		16718917	188461	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	412	6	1	4	5.0	CC1=C(CCN(C)C)c2cc(NS(=O)(=O)c3csc4ccccc34)ccc2C1	10.1021/jm8009469
		CHEMBL477650	188461	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	412	6	1	4	5.0	CC1=C(CCN(C)C)c2cc(NS(=O)(=O)c3csc4ccccc34)ccc2C1	10.1021/jm8009469
		168281847	197815	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assay	ChEMBL	310	3	1	4	3.6	COc1ccc(/C=C2\CCc3c(O)cccc3C2=O)cc1OC	10.1016/j.ejmech.2021.113964
		CHEMBL5187030	197815	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assay	ChEMBL	310	3	1	4	3.6	COc1ccc(/C=C2\CCc3c(O)cccc3C2=O)cc1OC	10.1016/j.ejmech.2021.113964
		14151613	63264	0	None	-	0	Bovine	7.2	pIC50	=	7.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	0	3	3.0	CCCN1CCC[C@@H]2c3c(OC)cccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL163281	63264	0	None	-	0	Bovine	7.2	pIC50	=	7.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	0	3	3.0	CCCN1CCC[C@@H]2c3c(OC)cccc3OC[C@H]21	10.1021/jm00123a039
		44390726	129182	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	449	7	2	7	3.9	COc1cc(OC)cc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		CHEMBL360081	129182	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	449	7	2	7	3.9	COc1cc(OC)cc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		23027245	203907	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL567791	203907	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		1971	9641	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	9641	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	9641	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	9641	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	9641	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4211	64596	83	None	-1	4	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		CHEMBL1670	64596	83	None	-1	4	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		1028	7079	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		139148732	7079	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		479	7079	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		5816	7079	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		CHEMBL679	7079	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		DB00668	7079	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		44390750	70252	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	423	5	2	5	4.5	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL179878	70252	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	423	5	2	5	4.5	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14151647	62437	1	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162170	62437	1	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		3082597	106335	8	None	-	1	Bovine	6.1	pIC50	=	6.1	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	106335	8	None	-	1	Bovine	6.1	pIC50	=	6.1	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		12575	8769	30	None	-5	17	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/s0960-894x(99)00591-0
		54459	8769	30	None	-5	17	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/s0960-894x(99)00591-0
		CHEMBL10316	8769	30	None	-5	17	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/s0960-894x(99)00591-0
		102	10899	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		3659	10899	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		8969	10899	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		CHEMBL15245	10899	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		DB01392	10899	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		118112300	162773	18	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity at alpha2A-adrenergic receptor (unknown origin)Antagonist activity at alpha2A-adrenergic receptor (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
		CHEMBL4061793	162773	18	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity at alpha2A-adrenergic receptor (unknown origin)Antagonist activity at alpha2A-adrenergic receptor (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
		CHEMBL5093818	222224	3	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		CN(CCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21)C1CCC(F)(F)CC1	10.1021/acs.jmedchem.1c01564
		3191	109635	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		1816	9318	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		4205	9318	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		7241	9318	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		CHEMBL654	9318	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		DB00370	9318	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		44401460	77682	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	391	7	2	6	2.5	CN(C)c1nc(NCC2CCC(CNS(C)(=O)=O)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL195123	77682	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	391	7	2	6	2.5	CN(C)c1nc(NCC2CCC(CNS(C)(=O)=O)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		14151595	63285	0	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	231	2	0	2	3.0	CCCN1CCC[C@@H]2c3ccccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL163532	63285	0	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	231	2	0	2	3.0	CCCN1CCC[C@@H]2c3ccccc3OC[C@H]21	10.1021/jm00123a039
		70788951	33928	1	None	-1	5	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1366	33928	1	None	-1	5	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		46227396	208419	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	420	4	2	6	3.4	O=S(=O)(Nc1ccc2c(c1)C(C1CCNC1)=CC2)c1c(Cl)nc2sccn12	10.1016/j.bmc.2009.08.006
		CHEMBL605938	208419	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	420	4	2	6	3.4	O=S(=O)(Nc1ccc2c(c1)C(C1CCNC1)=CC2)c1c(Cl)nc2sccn12	10.1016/j.bmc.2009.08.006
		42636941	185728	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptorDisplacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		CHEMBL470432	185728	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptorDisplacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		8447	195728	84	None	-4	13	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	195728	84	None	-4	13	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		2389	10104	118	None	-77	66	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	10104	118	None	-77	66	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	10104	118	None	-77	66	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	10104	118	None	-77	66	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	10104	118	None	-77	66	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		44390499	136435	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	8	2	6	6.0	CN(C)c1nc(NCC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL367355	136435	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	8	2	6	6.0	CN(C)c1nc(NCC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		135398737	7745	93	None	-26	90	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	7745	93	None	-26	90	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	7745	93	None	-26	90	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	7745	93	None	-26	90	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	7745	93	None	-26	90	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		213	10625	55	None	-10	43	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	10625	55	None	-10	43	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	10625	55	None	-10	43	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	10625	55	None	-10	43	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	10625	55	None	-10	43	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		3082597	106335	8	None	-	1	Bovine	5.0	pIC50	=	5.0	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	106335	8	None	-	1	Bovine	5.0	pIC50	=	5.0	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		36324	33896	76	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		CHEMBL1365675	33896	76	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		1548953	214458	27	None	-1	17	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	214458	27	None	-1	17	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		14450364	62777	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	1	0	3	2.6	COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		CHEMBL162449	62777	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	1	0	3	2.6	COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		44390768	71248	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	434	6	2	7	3.8	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc([N+](=O)[O-])c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181383	71248	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	434	6	2	7	3.8	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc([N+](=O)[O-])c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		1562	7686	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		5312114	7686	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		CHEMBL17645	7686	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		CHEMBL195380	7686	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		441383	27105	57	None	-2	17	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	27105	57	None	-2	17	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		164612037	192156	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	192156	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		168290235	199747	0	None	-40	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	199747	0	None	-40	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	199747	0	None	-40	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168294767	199798	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168295528	199810	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	199810	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	199810	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		118714540	121289	0	None	5	4	Human	9.0	pKd	=	9.0	Binding	Displacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 minsDisplacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 mins	ChEMBL	677	13	6	15	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(CCC(=O)Nc5ccc(OC(C)=O)c([N+](=O)[O-])c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/ml5002486
		CHEMBL3335523	121289	0	None	5	4	Human	9.0	pKd	=	9.0	Binding	Displacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 minsDisplacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 mins	ChEMBL	677	13	6	15	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(CCC(=O)Nc5ccc(OC(C)=O)c([N+](=O)[O-])c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/ml5002486
		521	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		5311068	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		835	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		CHEMBL778	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		DB00633	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		521	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		5311068	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		835	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		CHEMBL778	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		DB00633	8186	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		49781228	23977	1	None	2	4	Human	10.6	pKi	=	10.6	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		CHEMBL1256414	23977	1	None	2	4	Human	10.6	pKi	=	10.6	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		155540329	179254	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	426	7	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4482861	179254	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	426	7	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		78114674	180505	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	380	7	0	7	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4536304	180505	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	380	7	0	7	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		155513359	176542	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	471	8	0	8	3.9	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cccc([N+](=O)[O-])c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4438801	176542	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	471	8	0	8	3.9	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cccc([N+](=O)[O-])c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		49781228	23977	1	None	2	4	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		CHEMBL1256414	23977	1	None	2	4	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		49781228	23977	1	None	2	4	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		CHEMBL1256414	23977	1	None	2	4	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		11271808	67768	0	None	1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	490	9	0	7	3.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OCCN(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL176261	67768	0	None	1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	490	9	0	7	3.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OCCN(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		11306100	175286	0	None	-3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	477	9	0	7	3.5	COCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL435352	175286	0	None	-3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	477	9	0	7	3.5	COCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		1588	9105	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	9105	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	9105	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	9105	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	9105	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		52944548	23924	0	None	1	4	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.0	CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255723	23924	0	None	1	4	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.0	CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		52941512	23970	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256378	23970	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		135519400	70668	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	419	5	1	6	3.2	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL180470	70668	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	419	5	1	6	3.2	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1	10.1021/jm049619s
		49781222	24023	0	None	2	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	3.0	C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256609	24023	0	None	2	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	3.0	C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		46224879	208326	3	None	-1	7	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL605405	208326	3	None	-1	7	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		124	9755	47	None	-4	32	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		2032	9755	47	None	-4	32	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		4636	9755	47	None	-4	32	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		CHEMBL762	9755	47	None	-4	32	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		DB00935	9755	47	None	-4	32	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		44330168	11091	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL100879	11091	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		11225779	114509	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cc(F)ccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL319119	114509	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cc(F)ccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324972	170151	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL419316	170151	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324972	170151	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL419316	170151	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44324800	213727	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91157	213727	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44324972	170151	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL419316	170151	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		44324800	213727	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL91157	213727	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		78114597	179263	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	356	6	0	6	2.6	CCOP(=O)(OCC)C1N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4483022	179263	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	356	6	0	6	2.6	CCOP(=O)(OCC)C1N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		49781887	23916	0	None	3	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		CHEMBL1255617	23916	0	None	3	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		9837136	106714	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm990569e
		CHEMBL286269	106714	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm990569e
		9837136	106714	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm000128r
		CHEMBL286269	106714	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm000128r
		108094	10196	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		526	10196	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		528	10196	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		CHEMBL10332	10196	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		10531	8202	21	None	-5	24	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	8202	21	None	-5	24	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	8202	21	None	-5	24	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	8202	21	None	-5	24	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	8202	21	None	-5	24	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		10056237	20516	0	None	47	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	817	13	6	6	7.3	O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1195197	20516	0	None	47	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	817	13	6	6	7.3	O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL554019	20516	0	None	47	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	817	13	6	6	7.3	O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		2803	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		516	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		704	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		CHEMBL134	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		DB00575	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		2803	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		516	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		704	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		CHEMBL134	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		DB00575	7742	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		11259744	67570	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	461	6	0	7	3.4	CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL176116	67570	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	461	6	0	7	3.4	CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		52948958	23925	0	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.4	CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255724	23925	0	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.4	CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		102	10899	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		3659	10899	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		8969	10899	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		CHEMBL15245	10899	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		DB01392	10899	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		52943739	23931	0	None	2	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12	10.1021/jm1006269
		CHEMBL1255771	23931	0	None	2	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12	10.1021/jm1006269
		44387789	67349	0	None	-2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	433	6	0	6	3.5	COc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL176002	67349	0	None	-2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	433	6	0	6	3.5	COc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		44330114	114859	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL319530	114859	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324906	213566	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1	10.1016/s0960-894x(03)00525-0
		CHEMBL90247	213566	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1	10.1016/s0960-894x(03)00525-0
		49781223	24024	0	None	2	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.3	CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256610	24024	0	None	2	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.3	CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		9815633	106411	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		CHEMBL284213	106411	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		9815633	106411	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		CHEMBL284213	106411	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		49781005	23986	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256503	23986	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		49781887	23916	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		CHEMBL1255617	23916	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		11214030	67318	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	491	8	0	8	3.1	COCC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL175853	67318	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	491	8	0	8	3.1	COCC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		107715	207724	22	None	-6	20	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	207724	22	None	-6	20	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	207724	22	None	-6	20	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		11765813	19750	0	None	60	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	788	11	6	6	6.5	O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1189483	19750	0	None	60	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	788	11	6	6	6.5	O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL538808	19750	0	None	60	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	788	11	6	6	6.5	O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		13938361	192142	0	None	141	2	Bovine	9.1	pKi	=	9.1	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@@H]1CCN2CCc3c(oc4ccccc34)[C@@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		CHEMBL48603	192142	0	None	141	2	Bovine	9.1	pKi	=	9.1	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@@H]1CCN2CCc3c(oc4ccccc34)[C@@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		1043	8363	14	None	-8	29	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	8363	14	None	-8	29	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	8363	14	None	-8	29	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	8363	14	None	-8	29	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	8363	14	None	-8	29	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		44324800	213727	0	None	-5	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL91157	213727	0	None	-5	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324887	171794	0	None	2	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL422597	171794	0	None	2	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44325050	214060	0	None	-3	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL93171	214060	0	None	-3	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44126269	208263	5	None	-2	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
		CHEMBL605081	208263	5	None	-2	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
		49781224	23915	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.7	CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255616	23915	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.7	CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		12114852	20092	0	None	31	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	774	10	6	6	6.1	O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1192051	20092	0	None	31	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	774	10	6	6	6.1	O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL543232	20092	0	None	31	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	774	10	6	6	6.1	O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		11785068	67330	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	7	3.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C5CC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL175911	67330	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	7	3.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C5CC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		11260018	70633	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	473	7	0	7	3.6	C=CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL180322	70633	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	473	7	0	7	3.6	C=CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		71450907	85714	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL2112978	85714	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4OC[C@H]32)CC1	10.1021/jm049619s
		44324937	213692	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1	10.1016/s0960-894x(03)00525-0
		CHEMBL90943	213692	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1	10.1016/s0960-894x(03)00525-0
		2142	9870	58	None	1	37	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		4920903	9870	58	None	1	37	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		502	9870	58	None	1	37	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		5775	9870	58	None	1	37	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		CHEMBL597	9870	58	None	1	37	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		DB00692	9870	58	None	1	37	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		155547631	180473	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	432	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4535472	180473	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	432	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		11318438	172763	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	524	7	0	8	4.1	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)c5ccncc5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL425324	172763	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	524	7	0	8	4.1	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)c5ccncc5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		9805944	63001	37	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [125I]HEAT from adrenergic alpha2A receptorDisplacement of [125I]HEAT from adrenergic alpha2A receptor	ChEMBL	462	7	2	3	4.7	CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	10.1021/jm800510m
		CHEMBL1627	63001	37	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [125I]HEAT from adrenergic alpha2A receptorDisplacement of [125I]HEAT from adrenergic alpha2A receptor	ChEMBL	462	7	2	3	4.7	CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	10.1021/jm800510m
		44330635	215205	0	None	-2	2	Human	9.0	pKi	=	9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1ccccc1/C=C(\C)CN1CCN(C[C@@H]2ON=C3c4cc(OC)c(OC)cc4OC[C@H]32)CC1	10.1016/j.bmcl.2004.03.031
		CHEMBL99868	215205	0	None	-2	2	Human	9.0	pKi	=	9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1ccccc1/C=C(\C)CN1CCN(C[C@@H]2ON=C3c4cc(OC)c(OC)cc4OC[C@H]32)CC1	10.1016/j.bmcl.2004.03.031
		52950140	23930	0	None	1	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	1	1	1	3.0	CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255770	23930	0	None	1	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	1	1	1	3.0	CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1	10.1021/jm1006269
		44330668	11208	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL101596	11208	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44330617	103395	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL263424	103395	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44371848	20397	0	None	15	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	845	15	6	6	8.1	O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1194334	20397	0	None	15	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	845	15	6	6	8.1	O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL551711	20397	0	None	15	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	845	15	6	6	8.1	O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		9837551	108401	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	232	1	3	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCO2	10.1021/jm960359r
		CHEMBL298936	108401	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	232	1	3	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCO2	10.1021/jm960359r
		12114853	19800	0	None	35	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	803	12	6	6	6.9	O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1189875	19800	0	None	35	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	803	12	6	6	6.9	O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL539606	19800	0	None	35	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	803	12	6	6	6.9	O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		10847653	64219	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	240	0	1	2	2.6	C1=NC[C@]2(CC[C@@H]3Cc4ccccc4C[C@H]3C2)N1	10.1021/jm001040g
		CHEMBL165529	64219	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	240	0	1	2	2.6	C1=NC[C@]2(CC[C@@H]3Cc4ccccc4C[C@H]3C2)N1	10.1021/jm001040g
		11785961	70054	0	None	-6	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	535	13	0	8	4.0	CCOCCOCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL179237	70054	0	None	-6	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	535	13	0	8	4.0	CCOCCOCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		11190988	138581	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	6	4.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC5CCCC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL369378	138581	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	6	4.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC5CCCC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		136019934	151308	0	None	-7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		CHEMBL390718	151308	0	None	-7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		44324737	214017	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL92860	214017	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44324737	214017	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL92860	214017	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
		10123375	20022	0	None	123	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	760	9	6	6	5.8	O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1191431	20022	0	None	123	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	760	9	6	6	5.8	O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL542527	20022	0	None	123	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	760	9	6	6	5.8	O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		13938356	191857	0	None	154	2	Bovine	8.9	pKi	=	8.9	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN(C1CCN2CCc3c(oc4ccccc34)C2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		CHEMBL48558	191857	0	None	154	2	Bovine	8.9	pKi	=	8.9	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN(C1CCN2CCc3c(oc4ccccc34)C2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		44330369	118359	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL328195	118359	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		102	10899	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		3659	10899	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		8969	10899	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		CHEMBL15245	10899	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		DB01392	10899	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		44325049	118300	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL327875	118300	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		10707358	186064	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	272	4	1	3	3.2	c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL47313	186064	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	272	4	1	3	3.2	c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		12575	8769	30	None	1	17	Bovine	8.8	pKi	=	8.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm00366a007
		54459	8769	30	None	1	17	Bovine	8.8	pKi	=	8.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm00366a007
		CHEMBL10316	8769	30	None	1	17	Bovine	8.8	pKi	=	8.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm00366a007
		9815610	106709	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		CHEMBL286246	106709	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		124	9755	47	None	-5	32	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		2032	9755	47	None	-5	32	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		4636	9755	47	None	-5	32	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		CHEMBL762	9755	47	None	-5	32	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		DB00935	9755	47	None	-5	32	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		9815610	106709	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		CHEMBL286246	106709	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		11200476	85706	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for Alpha-2A adrenergic receptorBinding affinity for Alpha-2A adrenergic receptor	ChEMBL	402	5	0	5	3.2	CN1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112970	85706	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for Alpha-2A adrenergic receptorBinding affinity for Alpha-2A adrenergic receptor	ChEMBL	402	5	0	5	3.2	CN1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		9837600	30092	0	None	12	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	236	0	1	3	1.9	NC1=NC2(CCc3cccc(Cl)c3C2)CO1	10.1021/jm00020a021
		CHEMBL133231	30092	0	None	12	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	236	0	1	3	1.9	NC1=NC2(CCc3cccc(Cl)c3C2)CO1	10.1021/jm00020a021
		46891598	13948	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]rauwolscine from adrenergic alpha2A receptorDisplacement of [3H]rauwolscine from adrenergic alpha2A receptor	ChEMBL	402	5	0	5	3.2	CN1CC2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2010.04.099
		CHEMBL1085510	13948	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]rauwolscine from adrenergic alpha2A receptorDisplacement of [3H]rauwolscine from adrenergic alpha2A receptor	ChEMBL	402	5	0	5	3.2	CN1CC2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2010.04.099
		42266865	22375	2	None	1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	389	6	1	4	3.4	COc1ccccc1N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221498	22375	2	None	1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	389	6	1	4	3.4	COc1ccccc1N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		2142	9870	58	None	-2	37	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		4920903	9870	58	None	-2	37	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		502	9870	58	None	-2	37	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		5775	9870	58	None	-2	37	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		CHEMBL597	9870	58	None	-2	37	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		DB00692	9870	58	None	-2	37	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		10176999	110331	21	None	11	3	Human	8.8	pKi	=	8.8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
		CHEMBL308570	110331	21	None	11	3	Human	8.8	pKi	=	8.8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
		44330653	215011	0	None	-8	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL98646	215011	0	None	-8	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44330645	215213	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL99916	215213	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		10350094	20589	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	746	8	6	6	5.4	O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1195716	20589	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	746	8	6	6	5.4	O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL555190	20589	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	746	8	6	6	5.4	O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		49781005	23986	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256503	23986	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		13123525	195977	0	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		CHEMBL51131	195977	0	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		13123534	196232	1	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		CHEMBL51358	196232	1	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		71461647	85708	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	439	5	0	5	4.4	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		CHEMBL2112972	85708	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	439	5	0	5	4.4	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		71456240	85717	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	415	6	0	5	3.8	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(C/C=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL2112982	85717	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	415	6	0	5	3.8	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(C/C=C/c2ccccc2)CC1	10.1021/jm049619s
		102	10899	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		3659	10899	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		8969	10899	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		CHEMBL15245	10899	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		DB01392	10899	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		12576	7302	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		71310	7302	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		CHEMBL353972	7302	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		DB11481	7302	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		44330368	118969	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	479	7	1	8	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(O)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL329065	118969	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	479	7	1	8	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(O)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		108094	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		526	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		528	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		CHEMBL10332	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		42631003	206397	13	None	-10	8	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL592752	206397	13	None	-10	8	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		10198135	211904	3	None	43	3	Human	8.0	pKi	=	8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	203	3	2	3	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1	10.1021/jm9605142
		CHEMBL77913	211904	3	None	43	3	Human	8.0	pKi	=	8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	203	3	2	3	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1	10.1021/jm9605142
		2389	10104	118	None	-77	66	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		5073	10104	118	None	-77	66	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		96	10104	118	None	-77	66	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		CHEMBL85	10104	118	None	-77	66	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		DB00734	10104	118	None	-77	66	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		44401243	175273	0	None	-4	9	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL435301	175273	0	None	-4	9	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		49836302	25338	1	None	1	3	Human	7.0	pKi	=	7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276139	25338	1	None	1	3	Human	7.0	pKi	=	7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml400232p
		10176715	163913	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	2	2.4	C1=NCC(CC2=Cc3ccccc3CC2)N1	10.1021/jm001040g
		CHEMBL407509	163913	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	2	2.4	C1=NCC(CC2=Cc3ccccc3CC2)N1	10.1021/jm001040g
		242	7258	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	7258	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	7258	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	7258	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	7258	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		250	10159	8	None	-2818	13	Human	7.0	pKi	=	7	Binding	Compound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		5311416	10159	8	None	-2818	13	Human	7.0	pKi	=	7	Binding	Compound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		CHEMBL69733	10159	8	None	-2818	13	Human	7.0	pKi	=	7	Binding	Compound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		135398737	7745	93	None	-10	90	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		38	7745	93	None	-10	90	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		722	7745	93	None	-10	90	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		CHEMBL42	7745	93	None	-10	90	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		DB00363	7745	93	None	-10	90	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		49836302	25338	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276139	25338	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/jm100977d
		49836302	25338	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml300064v
		CHEMBL1276139	25338	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml300064v
		13938357	108507	0	None	79	2	Bovine	7.0	pKi	=	7	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@H]1CCN2CCc3c(oc4ccccc34)[C@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		CHEMBL299595	108507	0	None	79	2	Bovine	7.0	pKi	=	7	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@H]1CCN2CCc3c(oc4ccccc34)[C@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		135398737	7745	93	None	-26	90	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	7745	93	None	-26	90	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	7745	93	None	-26	90	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	7745	93	None	-26	90	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	7745	93	None	-26	90	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		135398745	9688	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	9688	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	9688	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	9688	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		2389	10104	118	None	-77	66	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	10104	118	None	-77	66	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	10104	118	None	-77	66	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	10104	118	None	-77	66	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	10104	118	None	-77	66	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		90644728	119529	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	1	2.1	CC1CN/C(=N/c2ccc3c(c2)CCCC3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289543	119529	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	1	2.1	CC1CN/C(=N/c2ccc3c(c2)CCCC3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305161	119529	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	1	2.1	CC1CN/C(=N/c2ccc3c(c2)CCCC3)N1	10.1016/j.ejmech.2014.05.057
		16090600	175960	0	None	-10	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	6	2	4	5.1	Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C	10.1021/jm060262x
		CHEMBL440594	175960	0	None	-10	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	6	2	4	5.1	Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C	10.1021/jm060262x
		10324985	83556	8	None	-741	17	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha-2A receptorBinding affinity to adrenergic alpha-2A receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL199824	83556	8	None	-741	17	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha-2A receptorBinding affinity to adrenergic alpha-2A receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL2068762	83556	8	None	-741	17	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha-2A receptorBinding affinity to adrenergic alpha-2A receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		127035062	143229	0	None	-3	19	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	143229	0	None	-3	19	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		10443343	25272	1	None	-	1	Bovine	6.0	pKi	=	6.0	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	0	5	0.5	CN1CCN(c2nccn3ccnc23)CC1	10.1021/jm00099a012
		CHEMBL127303	25272	1	None	-	1	Bovine	6.0	pKi	=	6.0	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	0	5	0.5	CN1CCN(c2nccn3ccnc23)CC1	10.1021/jm00099a012
		1782	9296	84	None	-5	23	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		241	9296	84	None	-5	23	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		4168	9296	84	None	-5	23	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		CHEMBL86	9296	84	None	-5	23	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		DB01233	9296	84	None	-5	23	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		44574076	179240	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL448147	179240	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		9960497	123853	0	None	-309	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		CHEMBL3392246	123853	0	None	-309	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		57395731	77965	0	None	6	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956202	77965	0	None	6	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		44312037	211398	1	None	1	6	Human	5.0	pKi	=	5.0	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL73392	211398	1	None	1	6	Human	5.0	pKi	=	5.0	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		3151	8244	97	None	-99	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	8244	97	None	-99	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	8244	97	None	-99	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	8244	97	None	-99	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	8244	97	None	-99	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		12909387	69411	0	None	-33	2	Bovine	6.0	pKi	=	6.0	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	301	0	0	3	3.8	CN1CCC(=C2c3cc(C#N)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL178376	69411	0	None	-33	2	Bovine	6.0	pKi	=	6.0	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	301	0	0	3	3.8	CN1CCC(=C2c3cc(C#N)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		9904117	16174	3	None	1	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL111554	16174	3	None	1	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		11091738	124870	0	None	-3	5	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		CHEMBL340641	124870	0	None	-3	5	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		57402718	77964	2	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956201	77964	2	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		2803	7742	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		516	7742	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		704	7742	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		CHEMBL134	7742	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		DB00575	7742	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		16090624	89176	0	None	-13	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL217278	89176	0	None	-13	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		4209	9937	75	None	-74	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	9937	75	None	-74	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	9937	75	None	-74	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	9937	75	None	-74	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	9937	75	None	-74	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	9937	75	None	-74	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		277	8083	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	8083	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	8083	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	8083	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	8083	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		1268096	22937	26	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL122404	22937	26	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		90644708	119519	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	5	3	3	2.4	CCNc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289530	119519	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	5	3	3	2.4	CCNc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304993	119519	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	5	3	3	2.4	CCNc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		68617	212306	62	None	-3	26	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	212306	62	None	-3	26	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	212306	62	None	-3	26	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		10769331	118310	0	None	-208	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	566	9	2	7	5.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1	10.1021/jm980077m
		CHEMBL327931	118310	0	None	-208	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	566	9	2	7	5.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1	10.1021/jm980077m
		197033	205931	64	None	-13	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL589390	205931	64	None	-13	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		13298529	107996	57	None	134	2	Bovine	8.0	pKi	=	8.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	241	1	1	3	1.3	Brc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL295921	107996	57	None	134	2	Bovine	8.0	pKi	=	8.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	241	1	1	3	1.3	Brc1cccnc1N1CCNCC1	10.1021/jm00366a007
		71456238	85713	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	504	9	0	7	4.4	COc1cc2c(cc1OC)N(C)C[C@@H]1C2=NO[C@H]1CN1CCN(CCC/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL2112977	85713	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	504	9	0	7	4.4	COc1cc2c(cc1OC)N(C)C[C@@H]1C2=NO[C@H]1CN1CCN(CCC/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		46934426	22397	0	None	4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	431	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221591	22397	0	None	4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	431	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		49781004	23985	0	None	2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256502	23985	0	None	2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1	10.1021/jm1006269
		44371755	55551	0	None	15	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL155866	55551	0	None	15	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		90469115	192621	4	None	-36	17	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human adrenergic alpha 2A receptorBinding affinity to human adrenergic alpha 2A receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		CHEMBL4867565	192621	4	None	-36	17	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human adrenergic alpha 2A receptorBinding affinity to human adrenergic alpha 2A receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		9809007	179343	8	None	-1905	6	Human	6.0	pKi	=	6.0	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		CHEMBL448620	179343	8	None	-1905	6	Human	6.0	pKi	=	6.0	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		10109188	172854	0	None	-43	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	4	1	4	4.6	CCc1c(C)nc2ccccc2c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		CHEMBL425803	172854	0	None	-43	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	4	1	4	4.6	CCc1c(C)nc2ccccc2c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		44574103	179367	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	250	2	0	4	2.4	c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL448908	179367	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	250	2	0	4	2.4	c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		162661022	188227	0	None	-	1	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4764318	188227	0	None	-	1	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		3168	16034	92	None	-123	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	16034	92	None	-123	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		1227	9267	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	9267	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	9267	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	9267	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	9267	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	9267	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2435	7509	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		395	7509	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		520	7509	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		5386	7509	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		CHEMBL844	7509	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		DB00484	7509	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		44574079	196088	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL512289	196088	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1	10.1016/j.bmcl.2009.03.166
		10531766	213776	0	None	-999	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	9	2	7	6.3	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		CHEMBL91415	213776	0	None	-999	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	9	2	7	6.3	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		62381476	119544	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	4	3	2	2.1	CCCNC(=N)Nc1ccc(N(C)C)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289536	119544	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	4	3	2	2.1	CCCNC(=N)Nc1ccc(N(C)C)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305461	119544	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	4	3	2	2.1	CCCNC(=N)Nc1ccc(N(C)C)cc1	10.1016/j.ejmech.2014.05.057
		122295	16640	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		CHEMBL114166	16640	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		122295	16640	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00019a001
		CHEMBL114166	16640	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00019a001
		44574104	196268	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	353	4	1	4	3.3	CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL513871	196268	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	353	4	1	4	3.3	CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		145990586	173622	0	None	-89	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		CHEMBL4285281	173622	0	None	-89	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		2335	18620	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	18620	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	18620	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	18620	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		176	7186	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		44424855	92229	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL226636	92229	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		44325038	213695	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ncccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL90966	213695	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ncccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		127026052	144331	0	None	-7	19	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754496	144331	0	None	-7	19	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		16090630	90012	0	None	-309	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO	10.1021/jm060262x
		CHEMBL218675	90012	0	None	-309	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO	10.1021/jm060262x
		10579368	112781	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	9	3	6	5.3	CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL313251	112781	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	9	3	6	5.3	CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		155526524	177964	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	364	6	0	6	2.4	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4459090	177964	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	364	6	0	6	2.4	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644720	119535	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	3	4	4	0.3	N=C(NCCO)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289524	119535	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	3	4	4	0.3	N=C(NCCO)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305319	119535	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	3	4	4	0.3	N=C(NCCO)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		44579230	188323	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
		CHEMBL476569	188323	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
		10316512	23639	2	None	-18	2	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	359	1	1	5	1.7	Brc1cnc(N2CCNCC2)c2ncc(Br)n12	10.1021/jm00099a012
		CHEMBL124926	23639	2	None	-18	2	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	359	1	1	5	1.7	Brc1cnc(N2CCNCC2)c2ncc(Br)n12	10.1021/jm00099a012
		10081626	27867	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	204	0	1	2	1.7	Fc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL131220	27867	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	204	0	1	2	1.7	Fc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		10262765	123333	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CCC1(CN=CN1)C2	10.1021/jm00020a021
		CHEMBL336332	123333	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CCC1(CN=CN1)C2	10.1021/jm00020a021
		398712	84644	5	None	-12	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cellsDisplacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		CHEMBL209324	84644	5	None	-12	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cellsDisplacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		44325075	118542	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	465	8	0	8	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCC(=O)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328735	118542	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	465	8	0	8	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCC(=O)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44292196	186785	2	None	5	2	Bovine	6.9	pKi	=	6.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	287	3	0	3	3.1	Clc1cccnc1N1CCN(Cc2ccccc2)CC1	10.1021/jm00366a007
		CHEMBL47471	186785	2	None	5	2	Bovine	6.9	pKi	=	6.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	287	3	0	3	3.1	Clc1cccnc1N1CCN(Cc2ccccc2)CC1	10.1021/jm00366a007
		9809007	179343	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		CHEMBL448620	179343	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		2775690	99786	53	None	-45	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenoceptor receptor (unknown origin)Binding affinity to alpha2A adrenoceptor receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		CHEMBL2441619	99786	53	None	-45	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenoceptor receptor (unknown origin)Binding affinity to alpha2A adrenoceptor receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		9809007	179343	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL448620	179343	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		11380132	91194	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccccn1)C1=NCCN1	10.1021/jm0408215
		CHEMBL221989	91194	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccccn1)C1=NCCN1	10.1021/jm0408215
		1268096	22937	26	None	-42	4	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptorCompound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL122404	22937	26	None	-42	4	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptorCompound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		92766	113319	35	None	-12	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL31410	113319	35	None	-12	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		24839550	144093	14	None	-1	15	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752576	144093	14	None	-1	15	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		11246610	91087	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL221523	91087	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1	10.1021/jm0408215
		16090626	88910	0	None	-77	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	3	1	4	4.9	Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL216727	88910	0	None	-77	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	3	1	4	4.9	Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		44421258	91521	0	None	3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL1204386	91521	0	None	3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL222933	91521	0	None	3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		90644730	119548	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	3	3	2	1.7	CCNc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289544	119548	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	3	3	2	1.7	CCNc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305465	119548	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	3	3	2	1.7	CCNc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		71452341	90472	7	None	-4	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
		CHEMBL2205361	90472	7	None	-4	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
		44269006	39127	1	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	5	1	3	1.8	C=CCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		CHEMBL14107	39127	1	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	5	1	3	1.8	C=CCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		24906243	194027	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1	10.1021/jm800250z
		CHEMBL492648	194027	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1	10.1021/jm800250z
		1267	10576	49	None	-52	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		3035905	10576	49	None	-52	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		CHEMBL260374	10576	49	None	-52	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		2284	9956	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	9956	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	9956	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	9956	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	9956	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		9839050	119156	0	None	-263	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		CHEMBL329566	119156	0	None	-263	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		9928335	126875	2	None	-3	6	Rat	6.9	pKi	=	6.9	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		CHEMBL35093	126875	2	None	-3	6	Rat	6.9	pKi	=	6.9	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		CHEMBL4520788	220754	10	None	-6	25	Human	6.9	pKi	=	6.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA2A	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		3038525	20321	114	None	-2	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		CHEMBL119385	20321	114	None	-2	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		181743	185351	5	None	-645	22	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Clonidine from human adrenergic alpha2A receptorDisplacement of [3H]Clonidine from human adrenergic alpha2A receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	185351	5	None	-645	22	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Clonidine from human adrenergic alpha2A receptorDisplacement of [3H]Clonidine from human adrenergic alpha2A receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		9827677	175201	0	None	-6456	7	Human	5.9	pKi	=	5.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	510	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL43491	175201	0	None	-6456	7	Human	5.9	pKi	=	5.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	510	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		10627021	113872	0	None	-933	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	577	9	2	5	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1	10.1021/jm980077m
		CHEMBL315914	113872	0	None	-933	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	577	9	2	5	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1	10.1021/jm980077m
		129211	10521	78	None	-120	16	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		2562	10521	78	None	-120	16	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		488	10521	78	None	-120	16	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		CHEMBL836	10521	78	None	-120	16	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		DB00706	10521	78	None	-120	16	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		44292385	107898	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	270	3	1	3	2.6	c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL295186	107898	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	270	3	1	3	2.6	c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		10609673	110553	0	None	11	3	Human	6.9	pKi	=	6.9	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	233	4	2	4	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1OC	10.1021/jm9605142
		CHEMBL308863	110553	0	None	11	3	Human	6.9	pKi	=	6.9	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	233	4	2	4	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1OC	10.1021/jm9605142
		CHEMBL179334	70077	0	None	-7079	6	Human	5.9	pKi	=	5.9	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@H]1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		162664874	188955	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	519	9	5	11	1.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4782649	188955	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	519	9	5	11	1.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		71450550	90582	0	None	-2	16	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenergic receptorBinding affinity to alpha2A adrenergic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	90582	0	None	-2	16	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenergic receptorBinding affinity to alpha2A adrenergic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		9926529	16161	2	None	-1	5	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL111496	16161	2	None	-1	5	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		10221004	211010	0	None	-1	5	Human	5.9	pKi	=	5.9	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	5	2	5	0.9	CCS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70973	211010	0	None	-1	5	Human	5.9	pKi	=	5.9	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	5	2	5	0.9	CCS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		90644736	119549	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	3	2	3	2.3	CN(C)c1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289547	119549	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	3	2	3	2.3	CN(C)c1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305466	119549	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	3	2	3	2.3	CN(C)c1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		180	7189	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	7189	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	7189	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	7189	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	7189	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2726	7706	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		10475736	172642	0	None	-26	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	4	2	5	4.1	CN1CCN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CC1(C)C	10.1021/jm060262x
		CHEMBL424917	172642	0	None	-26	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	4	2	5	4.1	CN1CCN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CC1(C)C	10.1021/jm060262x
		3805301	108114	83	None	-1	2	Bovine	5.9	pKi	=	5.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		CHEMBL296787	108114	83	None	-1	2	Bovine	5.9	pKi	=	5.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		CHEMBL1350036	74572	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1909062	74572	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		44438148	100265	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL246229	100265	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		11779308	25275	8	None	4	2	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2nccn3c(Br)cnc23)CC1	10.1021/jm00099a012
		CHEMBL127318	25275	8	None	4	2	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2nccn3c(Br)cnc23)CC1	10.1021/jm00099a012
		44288877	175378	0	None	-1905	5	Human	4.9	pKi	=	4.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	549	7	1	5	4.3	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL43594	175378	0	None	-1905	5	Human	4.9	pKi	=	4.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	549	7	1	5	4.3	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		2484	215072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		CHEMBL990	215072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		599482	209763	9	None	-9	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
		CHEMBL6310	209763	9	None	-9	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
		119584	9373	102	None	-2	6	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		1848	9373	102	None	-2	6	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		242	9373	102	None	-2	6	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL60889	9373	102	None	-2	6	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		DB11675	9373	102	None	-2	6	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		44579228	188433	0	None	-57	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		CHEMBL477608	188433	0	None	-57	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		11265631	143187	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL373535	143187	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
		11265631	143187	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL373535	143187	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
		10317643	105316	0	None	-32	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	CC1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		CHEMBL276417	105316	0	None	-32	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	CC1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		2737203	190703	83	None	141	2	Bovine	7.9	pKi	=	7.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	188	1	1	4	0.4	N#Cc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL48137	190703	83	None	141	2	Bovine	7.9	pKi	=	7.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	188	1	1	4	0.4	N#Cc1cccnc1N1CCNCC1	10.1021/jm00366a007
		13123527	108567	3	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300053	108567	3	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		13123531	195020	0	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		CHEMBL49953	195020	0	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		10219	195575	37	None	-1	5	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL493439	195575	37	None	-1	5	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL50588	195575	37	None	-1	5	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		11211035	91778	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL223836	91778	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
		11211035	91778	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL223836	91778	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
		10376053	19907	0	None	2	3	Bovine	6.9	pKi	=	6.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		CHEMBL1190547	19907	0	None	2	3	Bovine	6.9	pKi	=	6.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		CHEMBL541088	19907	0	None	2	3	Bovine	6.9	pKi	=	6.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		16090622	89073	0	None	-165	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.4	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)C2)cc1	10.1021/jm060262x
		CHEMBL217202	89073	0	None	-165	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.4	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)C2)cc1	10.1021/jm060262x
		10070896	89971	0	None	-281	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	4	1	4	6.1	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1-c1ccccc1	10.1021/jm060262x
		CHEMBL218457	89971	0	None	-281	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	4	1	4	6.1	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1-c1ccccc1	10.1021/jm060262x
		44438166	100592	0	None	-33	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL247664	100592	0	None	-33	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	10.1016/j.bmcl.2006.12.094
		4428003	119541	17	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	179	3	3	2	1.4	CCOc1ccc(NC(=N)N)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289540	119541	17	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	179	3	3	2	1.4	CCOc1ccc(NC(=N)N)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305332	119541	17	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	179	3	3	2	1.4	CCOc1ccc(NC(=N)N)cc1	10.1016/j.ejmech.2014.05.057
		155566429	182706	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	378	7	0	6	2.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4587519	182706	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	378	7	0	6	2.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644758	119528	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	3	2	2	1.7	CCOc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289541	119528	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	3	2	2	1.7	CCOc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305160	119528	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	3	2	2	1.7	CCOc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		5472	212597	75	None	-1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL1717	212597	75	None	-1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL833	212597	75	None	-1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		10318507	65727	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cc(Cl)ccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL1689423	65727	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cc(Cl)ccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		2406	107180	89	None	-16	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	107180	89	None	-16	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		43260	12254	65	None	1	5	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	197	4	2	4	0.7	COc1ccc(OC)c(C(O)CN)c1	10.1021/jm030551a
		CHEMBL1076	12254	65	None	1	5	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	197	4	2	4	0.7	COc1ccc(OC)c(C(O)CN)c1	10.1021/jm030551a
		10758200	70191	0	None	-43	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		CHEMBL179648	70191	0	None	-43	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		1836	9370	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	9370	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	9370	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	9370	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	9370	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		44574135	195957	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	268	2	1	3	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL511211	195957	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	268	2	1	3	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1	10.1016/j.bmcl.2009.03.166
		90644702	119493	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	5	2	3	2.4	CCOc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289533	119493	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	5	2	3	2.4	CCOc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304532	119493	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	5	2	3	2.4	CCOc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		44311789	211514	0	None	-1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	345	1	2	5	3.1	Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL74342	211514	0	None	-1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	345	1	2	5	3.1	Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		9894818	105701	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm00019a001
		CHEMBL279436	105701	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm00019a001
		4189	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		131268	119679	27	None	26	3	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	203	1	1	5	0.1	c1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL331036	119679	27	None	26	3	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	203	1	1	5	0.1	c1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		3952	8669	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5353646	8669	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5443	8669	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5702063	8669	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL1331786	8669	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL420	8669	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		10266032	195660	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	286	5	1	3	3.5	c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL50720	195660	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	286	5	1	3	3.5	c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		12114851	19813	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	732	7	6	6	5.0	O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1189965	19813	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	732	7	6	6	5.0	O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL539824	19813	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	732	7	6	6	5.0	O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		44292386	108259	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		CHEMBL297827	108259	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		13123529	108640	0	None	-	1	Bovine	6.8	pKi	=	6.8	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300628	108640	0	None	-	1	Bovine	6.8	pKi	=	6.8	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		12574	9383	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		4810	9383	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		CHEMBL19236	9383	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		DB09242	9383	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		3584	10549	64	None	-251	14	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		5401	10549	64	None	-251	14	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		7302	10549	64	None	-251	14	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		CHEMBL611	10549	64	None	-251	14	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		DB01162	10549	64	None	-251	14	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		11041026	187004	48	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	162	1	2	2	0.7	NCC1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c01475
		CHEMBL4749860	187004	48	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	162	1	2	2	0.7	NCC1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c01475
		162645059	186193	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4740168	186193	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		162653032	187170	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	505	8	5	11	0.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4751862	187170	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	505	8	5	11	0.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		162654934	187370	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4754362	187370	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		9894818	105701	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL279436	105701	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		10474335	201471	23	None	-52	10	Human	5.8	pKi	=	5.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		CHEMBL53325	201471	23	None	-52	10	Human	5.8	pKi	=	5.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		90644710	119506	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	3	3	4	2.1	N=C(NCc1ccco1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289529	119506	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	3	3	4	2.1	N=C(NCc1ccco1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304670	119506	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	3	3	4	2.1	N=C(NCc1ccco1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		44421258	91521	0	None	3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL1204386	91521	0	None	3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL222933	91521	0	None	3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		62379598	119546	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	3	3	3	1.8	CCCNC(=N)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289539	119546	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	3	3	3	1.8	CCCNC(=N)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305463	119546	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	3	3	3	1.8	CCCNC(=N)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		5318	22348	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	22348	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	22348	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		5353853	24758	47	None	-16	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	24758	47	None	-16	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	24758	47	None	-16	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		101333429	123854	0	None	-3890	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1	10.1021/jm00019a001
		CHEMBL3392247	123854	0	None	-3890	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1	10.1021/jm00019a001
		11186523	134289	0	None	-109	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL366164	134289	0	None	-109	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		135356876	180853	0	None	-9	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assayBinding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assay	ChEMBL	464	5	2	6	5.5	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1	10.1021/acs.jmedchem.6b00044
		CHEMBL4544251	180853	0	None	-9	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assayBinding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assay	ChEMBL	464	5	2	6	5.5	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1	10.1021/acs.jmedchem.6b00044
		114697	10459	4	None	-8	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	263	1	2	3	2.7	Clc1ccc(cc1NC1=NCCN1)C(F)(F)F	10.1021/jm00020a021
		513	10459	4	None	-8	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	263	1	2	3	2.7	Clc1ccc(cc1NC1=NCCN1)C(F)(F)F	10.1021/jm00020a021
		CHEMBL101340	10459	4	None	-8	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	263	1	2	3	2.7	Clc1ccc(cc1NC1=NCCN1)C(F)(F)F	10.1021/jm00020a021
		12981869	175415	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1ccc2c(c1)C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		CHEMBL436234	175415	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1ccc2c(c1)C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		10508016	213935	0	None	-43	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	613	9	2	5	7.7	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1	10.1021/jm980077m
		CHEMBL92322	213935	0	None	-43	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	613	9	2	5	7.7	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1	10.1021/jm980077m
		132584404	150127	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	416	3	0	2	6.7	CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32	10.1016/j.bmcl.2016.10.065
		CHEMBL3897499	150127	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	416	3	0	2	6.7	CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32	10.1016/j.bmcl.2016.10.065
		135	9310	43	None	-4	56	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	9310	43	None	-4	56	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	9310	43	None	-4	56	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	9310	43	None	-4	56	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	9310	43	None	-4	56	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		44324800	213727	0	None	-5	7	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91157	213727	0	None	-5	7	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		14004040	58409	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL158371	58409	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		124	9755	47	None	-4	32	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		2032	9755	47	None	-4	32	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		4636	9755	47	None	-4	32	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		CHEMBL762	9755	47	None	-4	32	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		DB00935	9755	47	None	-4	32	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		14004040	58409	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL158371	58409	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		15391752	189109	0	None	-7	7	Human	7.8	pKi	=	7.8	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	411	7	1	5	4.6	CC(=O)Nc1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		CHEMBL4784373	189109	0	None	-7	7	Human	7.8	pKi	=	7.8	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	411	7	1	5	4.6	CC(=O)Nc1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		44371744	57095	0	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	270	7	1	3	2.9	C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL157206	57095	0	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	270	7	1	3	2.9	C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		11360447	91776	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
		CHEMBL223829	91776	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
		44350012	24796	0	None	6	3	Bovine	5.8	pKi	=	5.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	363	4	3	7	0.4	CC1CN=C2C(N3CCNCC3)=NC=CN21.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		CHEMBL126394	24796	0	None	6	3	Bovine	5.8	pKi	=	5.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	363	4	3	7	0.4	CC1CN=C2C(N3CCNCC3)=NC=CN21.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		6604117	194626	6	None	-16	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL2062340	194626	6	None	-16	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL49623	194626	6	None	-16	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		168290009	198597	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	267	1	2	5	2.0	Nc1ncc(/C=C2\CCc3c(O)cccc3C2=O)cn1	10.1016/j.ejmech.2021.113964
		CHEMBL5198566	198597	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	267	1	2	5	2.0	Nc1ncc(/C=C2\CCc3c(O)cccc3C2=O)cn1	10.1016/j.ejmech.2021.113964
		10660	21188	58	None	-43	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	21188	58	None	-43	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		6918276	22383	7	None	-16	8	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	22383	7	None	-16	8	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		3198	212292	76	None	-19	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-19	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-19	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		11140345	210950	0	None	-1	6	Human	6.8	pKi	=	6.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70692	210950	0	None	-1	6	Human	6.8	pKi	=	6.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
		122442272	145126	0	None	-11	15	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	145126	0	None	-11	15	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	145126	0	None	-11	15	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		49836306	25347	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276247	25347	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		21392988	211596	4	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	156	0	0	4	-0.3	C1COC(N2CCOCC2)=N1	10.1016/0960-894X(94)85032-1
		CHEMBL75201	211596	4	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	156	0	0	4	-0.3	C1COC(N2CCOCC2)=N1	10.1016/0960-894X(94)85032-1
		4209	9937	75	None	-263	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	9937	75	None	-263	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	9937	75	None	-263	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	9937	75	None	-263	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	9937	75	None	-263	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	9937	75	None	-263	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		1547484	7727	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	7727	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	7727	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	7727	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	7727	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		3645619	9808	20	None	-104	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at alpha-1 adrenergic receptorBinding affinity at alpha-1 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
		975	9808	20	None	-104	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at alpha-1 adrenergic receptorBinding affinity at alpha-1 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
		CHEMBL45244	9808	20	None	-104	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at alpha-1 adrenergic receptorBinding affinity at alpha-1 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
		132060720	169268	0	None	-4	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		CHEMBL4167315	169268	0	None	-4	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		44415569	172713	0	None	-107	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL425069	172713	0	None	-107	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		26987	7736	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		6063	7736	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		671	7736	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		CHEMBL1626	7736	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		DB00283	7736	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		9838192	118089	18	None	2	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1007/s00044-004-0020-z
		CHEMBL326702	118089	18	None	2	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1007/s00044-004-0020-z
		155523897	177649	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4454147	177649	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		155556443	181263	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	406	6	0	6	3.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C(C)(C)C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4554450	181263	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	406	6	0	6	3.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C(C)(C)C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		9838192	118089	18	None	2	6	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1021/jm030551a
		CHEMBL326702	118089	18	None	2	6	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1021/jm030551a
		136680384	214434	0	None	-380	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	694	16	4	8	4.9	CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		44328799	214434	0	None	-380	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	694	16	4	8	4.9	CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		CHEMBL95290	214434	0	None	-380	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	694	16	4	8	4.9	CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		90644742	119517	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	2	2	4	1.9	c1coc(C2CN/C(=N/c3ccc4c(c3)OCO4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289550	119517	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	2	2	4	1.9	c1coc(C2CN/C(=N/c3ccc4c(c3)OCO4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304990	119517	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	2	2	4	1.9	c1coc(C2CN/C(=N/c3ccc4c(c3)OCO4)N2)c1	10.1016/j.ejmech.2014.05.057
		135	9310	43	None	-5	56	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		1796	9310	43	None	-5	56	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		4184	9310	43	None	-5	56	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		CHEMBL6437	9310	43	None	-5	56	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		DB06148	9310	43	None	-5	56	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		3303	9024	46	None	-251	15	Human	6.8	pKi	=	6.8	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1021/acs.jmedchem.7b00151
		5311200	9024	46	None	-251	15	Human	6.8	pKi	=	6.8	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1021/acs.jmedchem.7b00151
		CHEMBL267014	9024	46	None	-251	15	Human	6.8	pKi	=	6.8	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1021/acs.jmedchem.7b00151
		10319299	88362	0	None	-48	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	408	4	1	4	5.7	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1-c1ccccc1	10.1021/jm060262x
		CHEMBL216290	88362	0	None	-48	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	408	4	1	4	5.7	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1-c1ccccc1	10.1021/jm060262x
		10177445	172821	0	None	-32	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	4	1	4	5.2	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C(C)C	10.1021/jm060262x
		CHEMBL425622	172821	0	None	-32	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	4	1	4	5.2	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C(C)C	10.1021/jm060262x
		CHEMBL1441214	46591	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1476898	46591	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		71454275	90823	0	None	-41	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]UK 14.304 from human adrenergic alpha2A receptorDisplacement of [3H]UK 14.304 from human adrenergic alpha2A receptor	ChEMBL	293	3	1	3	3.0	CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1	10.1021/jm300975f
		CHEMBL2207493	90823	0	None	-41	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]UK 14.304 from human adrenergic alpha2A receptorDisplacement of [3H]UK 14.304 from human adrenergic alpha2A receptor	ChEMBL	293	3	1	3	3.0	CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1	10.1021/jm300975f
		11221758	91392	0	None	7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1	10.1021/jm0408215
		CHEMBL222138	91392	0	None	7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1	10.1021/jm0408215
		90644716	119494	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	233	3	4	2	1.5	N=C(NCCO)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289526	119494	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	233	3	4	2	1.5	N=C(NCCO)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304535	119494	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	233	3	4	2	1.5	N=C(NCCO)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		16725934	154201	0	None	-87	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL392992	154201	0	None	-87	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		44574077	185539	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	267	2	0	4	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL468710	185539	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	267	2	0	4	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1	10.1016/j.bmcl.2009.03.166
		136	10065	32	None	-12	16	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		223	10065	32	None	-12	16	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		643606	10065	32	None	-12	16	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		CHEMBL10347	10065	32	None	-12	16	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		3024499	182252	73	None	20	2	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccc(N2CCNCC2)n1	10.1021/jm00366a007
		CHEMBL45773	182252	73	None	20	2	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccc(N2CCNCC2)n1	10.1021/jm00366a007
		11140347	211312	1	None	-2	6	Human	7.7	pKi	=	7.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL72768	211312	1	None	-2	6	Human	7.7	pKi	=	7.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		44292381	108171	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	244	2	1	3	2.7	c1ccc([C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL297228	108171	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	244	2	1	3	2.7	c1ccc([C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		25142456	89181	2	None	-89	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned adrenergic alpha 2A receptorBinding affinity to human cloned adrenergic alpha 2A receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		CHEMBL217299	89181	2	None	-89	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned adrenergic alpha 2A receptorBinding affinity to human cloned adrenergic alpha 2A receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		188249	46427	4	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		CHEMBL147463	46427	4	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		CHEMBL2022280	46427	4	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		73213195	111236	0	None	-61	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	111236	0	None	-61	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		164615845	191969	0	None	-1	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		CHEMBL4857492	191969	0	None	-1	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		5198	26205	54	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		CHEMBL12948	26205	54	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		68712	107114	60	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
		CHEMBL289480	107114	60	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
		57395663	77956	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.5	CC(Oc1ccccc1C(F)(F)F)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956193	77956	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.5	CC(Oc1ccccc1C(F)(F)F)C1=NCCN1	10.1016/j.bmc.2012.01.035
		122065	196328	3	None	-3630	8	Human	5.7	pKi	=	5.7	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	380	5	1	6	1.5	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1	10.1021/jm970159v
		CHEMBL51433	196328	3	None	-3630	8	Human	5.7	pKi	=	5.7	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	380	5	1	6	1.5	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1	10.1021/jm970159v
		2247	7293	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		73213195	111236	0	None	-61	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	111236	0	None	-61	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		10379016	23264	2	None	-1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	281	1	1	5	0.9	Brc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		CHEMBL123566	23264	2	None	-1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	281	1	1	5	0.9	Brc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		3117	214620	103	None	-2	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	214620	103	None	-2	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		135398737	7745	93	None	-26	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		38	7745	93	None	-26	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		722	7745	93	None	-26	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		CHEMBL42	7745	93	None	-26	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		DB00363	7745	93	None	-26	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		10362866	89074	0	None	-371	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		CHEMBL217203	89074	0	None	-371	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		10474679	103952	0	None	-288	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	4.0	CN1CCN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CC1(C)C	10.1021/jm060262x
		CHEMBL268217	103952	0	None	-288	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	4.0	CN1CCN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CC1(C)C	10.1021/jm060262x
		44438168	100593	0	None	-53	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL247665	100593	0	None	-53	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		44324900	213677	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	423	6	0	7	2.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL90843	213677	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	423	6	0	7	2.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		11043720	98947	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL242265	98947	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		11043720	98947	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL242265	98947	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		44289035	107290	0	None	-977	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.4	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL291166	107290	0	None	-977	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.4	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		90644714	119547	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	4	4	3	0.7	CN(C)c1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289527	119547	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	4	4	3	0.7	CN(C)c1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305464	119547	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	4	4	3	0.7	CN(C)c1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		155538461	179180	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(C(F)(F)F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4476557	179180	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(C(F)(F)F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644718	119537	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	5	5	3	1.0	CCNc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289525	119537	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	5	5	3	1.0	CCNc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305320	119537	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	5	5	3	1.0	CCNc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		1353	8692	93	None	-190	85	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	8692	93	None	-190	85	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	8692	93	None	-190	85	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	8692	93	None	-190	85	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	8692	93	None	-190	85	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		16090601	89167	0	None	-208	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1c(CO)nc2ccccc2c1Nc1ccc(N2CCN(C)[C@H](C)C2)cc1	10.1021/jm060262x
		CHEMBL217254	89167	0	None	-208	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1c(CO)nc2ccccc2c1Nc1ccc(N2CCN(C)[C@H](C)C2)cc1	10.1021/jm060262x
		10873978	175265	0	None	-4	5	Rat	5.7	pKi	=	5.7	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		CHEMBL435218	175265	0	None	-4	5	Rat	5.7	pKi	=	5.7	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		135398737	7745	93	None	-10	90	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		38	7745	93	None	-10	90	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		722	7745	93	None	-10	90	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		CHEMBL42	7745	93	None	-10	90	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		DB00363	7745	93	None	-10	90	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		10106205	213916	1	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
		CHEMBL92221	213916	1	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
		12981870	64894	2	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	3	2.0	C1=NCC(Cc2cc3ccccc3o2)N1	10.1021/jm001040g
		CHEMBL167644	64894	2	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	3	2.0	C1=NCC(Cc2cc3ccccc3o2)N1	10.1021/jm001040g
		10465942	20317	0	None	1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL1193821	20317	0	None	1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL545289	20317	0	None	1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		16090596	89066	0	None	-275	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2c(C)cccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL217177	89066	0	None	-275	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2c(C)cccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		21584368	206631	3	None	-4	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1021/acs.jmedchem.0c01475
		CHEMBL59441	206631	3	None	-4	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1021/acs.jmedchem.0c01475
		90644712	119527	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	5	4	3	1.0	CCOc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289528	119527	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	5	4	3	1.0	CCOc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305159	119527	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	5	4	3	1.0	CCOc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		135398745	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		47	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		CHEMBL715	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		DB00334	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		162672516	189901	0	None	-3	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	425	8	1	5	5.0	CC(=O)Nc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		CHEMBL4794963	189901	0	None	-3	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	425	8	1	5	5.0	CC(=O)Nc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		127036186	144192	0	None	-6	19	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3753318	144192	0	None	-6	19	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		14004039	126339	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		CHEMBL346016	126339	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		12699315	83073	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	243	1	2	3	2.8	CC1CNC(Nc2c(Cl)cccc2Cl)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL2058631	83073	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	243	1	2	3	2.8	CC1CNC(Nc2c(Cl)cccc2Cl)=N1	10.1016/j.bmc.2012.06.008
		14004039	126339	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		CHEMBL346016	126339	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		44288874	107872	0	None	-1949	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	528	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL295001	107872	0	None	-1949	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	528	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		11034737	211307	0	None	2	6	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	289	4	2	4	2.8	CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL72724	211307	0	None	2	6	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	289	4	2	4	2.8	CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
		14004032	126612	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL348538	126612	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		185076	193869	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm960359r
		CHEMBL49137	193869	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm960359r
		185076	193869	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm9605142
		CHEMBL49137	193869	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm9605142
		2142	9870	58	None	1	37	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		4920903	9870	58	None	1	37	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		502	9870	58	None	1	37	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		5775	9870	58	None	1	37	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		CHEMBL597	9870	58	None	1	37	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		DB00692	9870	58	None	1	37	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		2142	9870	58	None	-2	37	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		4920903	9870	58	None	-2	37	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		502	9870	58	None	-2	37	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		5775	9870	58	None	-2	37	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		CHEMBL597	9870	58	None	-2	37	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		DB00692	9870	58	None	-2	37	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		124	9755	47	None	-4	32	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		2032	9755	47	None	-4	32	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		4636	9755	47	None	-4	32	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		CHEMBL762	9755	47	None	-4	32	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		DB00935	9755	47	None	-4	32	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		102	10899	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		3659	10899	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		8969	10899	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		CHEMBL15245	10899	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		DB01392	10899	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		218362	211579	5	None	-1	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
		CHEMBL75030	211579	5	None	-1	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
		73453	36389	24	None	-3	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	36389	24	None	-3	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		135440165	85720	0	None	-23	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112985	85720	0	None	-23	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		136019934	151308	0	None	-7	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		CHEMBL390718	151308	0	None	-7	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		9928332	103955	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/s0960-894x(03)00525-0
		CHEMBL268258	103955	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/s0960-894x(03)00525-0
		9928332	103955	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1021/jm049619s
		CHEMBL268258	103955	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1021/jm049619s
		10176567	109577	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		CHEMBL30534	109577	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		44324765	118345	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328114	118345	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		10176567	109577	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		CHEMBL30534	109577	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		44324765	118345	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL328114	118345	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		2142	9870	58	None	-2	37	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		4920903	9870	58	None	-2	37	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		502	9870	58	None	-2	37	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		5775	9870	58	None	-2	37	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		CHEMBL597	9870	58	None	-2	37	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		DB00692	9870	58	None	-2	37	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		11959098	186315	56	None	79	2	Bovine	8.6	pKi	=	8.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	0	3	1.5	CN1CCN(c2ncccc2Cl)CC1	10.1021/jm00366a007
		CHEMBL47415	186315	56	None	79	2	Bovine	8.6	pKi	=	8.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	0	3	1.5	CN1CCN(c2ncccc2Cl)CC1	10.1021/jm00366a007
		2435	7509	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		395	7509	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		520	7509	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		5386	7509	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		CHEMBL844	7509	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		DB00484	7509	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		3038495	7495	37	None	-1	18	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1016/j.bmcl.2010.07.002
		7625	7495	37	None	-1	18	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1016/j.bmcl.2010.07.002
		CHEMBL25236	7495	37	None	-1	18	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1016/j.bmcl.2010.07.002
		46934427	22400	0	None	3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	481	11	1	5	4.5	COc1ccccc1N1CCN(CCCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221594	22400	0	None	3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	481	11	1	5	4.5	COc1ccccc1N1CCN(CCCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		12203911	195062	22	None	54	2	Bovine	8.5	pKi	=	8.5	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	255	1	0	3	1.6	CN1CCN(c2ncccc2Br)CC1	10.1021/jm00366a007
		CHEMBL50017	195062	22	None	54	2	Bovine	8.5	pKi	=	8.5	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	255	1	0	3	1.6	CN1CCN(c2ncccc2Br)CC1	10.1021/jm00366a007
		9816063	109851	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		CHEMBL30739	109851	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		2216	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		229	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		7117	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		CHEMBL647	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		DB00964	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		44330584	114896	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL319573	114896	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		10480357	214997	0	None	-9	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL98541	214997	0	None	-9	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		9816063	109851	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		CHEMBL30739	109851	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		44314198	111189	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
		CHEMBL310335	111189	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
		9815707	108246	0	None	1	3	Human	8.5	pKi	=	8.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
		CHEMBL297752	108246	0	None	1	3	Human	8.5	pKi	=	8.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
		134551	7146	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	7146	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	7146	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	7146	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		11224953	85709	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	459	6	1	5	3.3	CCNC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112973	85709	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	459	6	1	5	3.3	CCNC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		135499867	85716	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	388	5	1	5	3.2	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4NC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL2112981	85716	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	388	5	1	5	3.2	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4NC[C@H]32)CC1	10.1021/jm049619s
		1816	9318	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		4205	9318	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		7241	9318	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		CHEMBL654	9318	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		DB00370	9318	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		49836303	25344	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276220	25344	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		2803	7742	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		516	7742	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		704	7742	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		CHEMBL134	7742	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		DB00575	7742	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		49836303	25344	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276220	25344	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		10848826	195659	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	258	3	1	3	2.8	c1ccc(C[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL50719	195659	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	258	3	1	3	2.8	c1ccc(C[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL508338	195745	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		14004032	126612	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL348538	126612	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		44415672	86949	0	None	-1659	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213492	86949	0	None	-1659	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11057	182928	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		44574106	185205	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	317	3	1	3	3.3	CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL466012	185205	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	317	3	1	3	3.3	CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		135398745	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	9688	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		1201549	7384	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	7384	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	7384	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	7384	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	7384	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	7384	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		11750482	154199	0	None	-25	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL392991	154199	0	None	-25	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		12909388	67830	0	None	-14	2	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	303	0	0	3	3.4	CN1CCC(=C2c3cc(C#N)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL176365	67830	0	None	-14	2	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	303	0	0	3	3.4	CN1CCC(=C2c3cc(C#N)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		3598	194600	76	None	-2	7	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	194600	76	None	-2	7	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		44579187	196458	0	None	-263	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
		CHEMBL515331	196458	0	None	-263	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
		132060733	168903	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	294	3	0	3	3.0	c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1	10.1016/j.ejmech.2018.02.024
		CHEMBL4161503	168903	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	294	3	0	3	3.0	c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1	10.1016/j.ejmech.2018.02.024
		11801828	213323	0	None	-128	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	606	9	3	6	5.0	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		CHEMBL88628	213323	0	None	-128	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	606	9	3	6	5.0	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		124	9755	47	None	-16	32	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		2032	9755	47	None	-16	32	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		4636	9755	47	None	-16	32	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		CHEMBL762	9755	47	None	-16	32	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		DB00935	9755	47	None	-16	32	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		123920	106930	41	None	309	2	Rat	7.7	pKi	=	7.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1021/jm0205752
		CHEMBL287837	106930	41	None	309	2	Rat	7.7	pKi	=	7.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1021/jm0205752
		4209	9937	75	None	-1380	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		4893	9937	75	None	-1380	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		503	9937	75	None	-1380	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		5385	9937	75	None	-1380	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		CHEMBL2	9937	75	None	-1380	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		DB00457	9937	75	None	-1380	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		13141182	137671	1	None	-10	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	354	0	0	2	4.7	CN1CCC(=C2c3cc(Br)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368578	137671	1	None	-10	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	354	0	0	2	4.7	CN1CCC(=C2c3cc(Br)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		10490084	211737	1	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	237	2	2	2	2.9	Brc1ccccc1Nc1ncc[nH]1	10.1021/jm9605142
		CHEMBL76457	211737	1	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	237	2	2	2	2.9	Brc1ccccc1Nc1ncc[nH]1	10.1021/jm9605142
		44574045	196065	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	260	2	0	2	3.9	c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.166
		CHEMBL512062	196065	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	260	2	0	2	3.9	c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.166
		50878551	97520	61	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	97520	61	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		24906197	194445	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	323	7	1	5	3.0	CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1	10.1021/jm800250z
		CHEMBL495097	194445	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	323	7	1	5	3.0	CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1	10.1021/jm800250z
		90644704	119492	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	4	2	3	2.1	CN(C)c1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289532	119492	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	4	2	3	2.1	CN(C)c1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304530	119492	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	4	2	3	2.1	CN(C)c1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		4209	9937	75	None	-1380	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	9937	75	None	-1380	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	9937	75	None	-1380	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	9937	75	None	-1380	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	9937	75	None	-1380	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	9937	75	None	-1380	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		10793665	113729	0	None	-1202	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	597	9	2	5	7.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1	10.1021/jm980077m
		CHEMBL314960	113729	0	None	-1202	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	597	9	2	5	7.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1	10.1021/jm980077m
		1549008	212459	85	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		CHEMBL822	212459	85	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		44438161	153919	0	None	-22	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL392771	153919	0	None	-22	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		2520	210787	70	None	-6	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL1280	210787	70	None	-6	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL6966	210787	70	None	-6	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		12488	8438	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	8438	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	8438	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	8438	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		11098175	210949	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
		CHEMBL70691	210949	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
		10841190	113819	0	None	-309	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	2	6	6.5	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1	10.1021/jm980077m
		CHEMBL315538	113819	0	None	-309	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	2	6	6.5	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1	10.1021/jm980077m
		90644740	119507	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	4	3	3	2.6	CCNc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289549	119507	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	4	3	3	2.6	CCNc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304693	119507	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	4	3	3	2.6	CCNc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL1200633	215379	3	None	-7	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		133	9274	52	None	-23	43	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	9274	52	None	-23	43	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	9274	52	None	-23	43	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	9274	52	None	-23	43	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	9274	52	None	-23	43	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		44330679	215053	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	464	7	0	8	2.9	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccnc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL98889	215053	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	464	7	0	8	2.9	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccnc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324859	118389	0	None	-4	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	461	6	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CC4=Cc5ccccc5C4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328377	118389	0	None	-4	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	461	6	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CC4=Cc5ccccc5C4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44549156	25342	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276218	25342	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		57345626	77955	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1021/ml400232p
		CHEMBL1956192	77955	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1021/ml400232p
		57345626	77955	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956192	77955	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1016/j.bmc.2012.01.035
		45487956	205146	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	3	1	3	2.6	CC(OC1=NCCN1)c1ccccc1C1CC1	10.1021/jm901262f
		CHEMBL576623	205146	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	3	1	3	2.6	CC(OC1=NCCN1)c1ccccc1C1CC1	10.1021/jm901262f
		44549156	25342	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276218	25342	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		11347303	118157	0	None	-1	5	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2	10.1021/jm030551a
		CHEMBL327116	118157	0	None	-1	5	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2	10.1021/jm030551a
		44579185	188593	1	None	-28	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		CHEMBL477816	188593	1	None	-28	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		5288606	103959	26	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	259	0	1	1	1.9	Ic1ccc2c(c1)CNCC2	10.1021/jm0205752
		CHEMBL26828	103959	26	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	259	0	1	1	1.9	Ic1ccc2c(c1)CNCC2	10.1021/jm0205752
		16090602	89223	0	None	-239	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	362	4	2	5	3.6	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1C	10.1021/jm060262x
		CHEMBL217542	89223	0	None	-239	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	362	4	2	5	3.6	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1C	10.1021/jm060262x
		164618319	191372	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	340	2	1	4	2.1	CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4848838	191372	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	340	2	1	4	2.1	CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		10132386	103873	2	None	-63	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C	10.1021/jm060262x
		CHEMBL267464	103873	2	None	-63	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C	10.1021/jm060262x
		155566702	182685	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	472	9	0	6	4.2	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CCc3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4587003	182685	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	472	9	0	6	4.2	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CCc3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644722	119491	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	4	3	2	3.5	CCOc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289523	119491	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	4	3	2	3.5	CCOc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304529	119491	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	4	3	2	3.5	CCOc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		49783209	24381	0	None	-3890	26	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human adrenergic alpha2A receptorBinding affinity to human adrenergic alpha2A receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	24381	0	None	-3890	26	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human adrenergic alpha2A receptorBinding affinity to human adrenergic alpha2A receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		9906978	49485	2	None	-165	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL150161	49485	2	None	-165	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		9837106	110934	2	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		CHEMBL30955	110934	2	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		9837106	110934	2	None	8	4	Rat	6.7	pKi	=	6.7	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		CHEMBL30955	110934	2	None	8	4	Rat	6.7	pKi	=	6.7	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		1443	8809	34	None	-23	11	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		33625	8809	34	None	-23	11	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		501	8809	34	None	-23	11	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		CHEMBL279516	8809	34	None	-23	11	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		DB08950	8809	34	None	-23	11	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		2162	48288	100	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		CHEMBL1491	48288	100	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		12909385	67203	1	None	-7	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	276	0	0	2	4.0	CN1CCC(=C2c3ccccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL175154	67203	1	None	-7	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	276	0	0	2	4.0	CN1CCC(=C2c3ccccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		135453290	140384	33	None	-758	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		CHEMBL371300	140384	33	None	-758	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		21509921	111235	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	111235	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		44288945	175694	0	None	-575	7	Human	6.6	pKi	=	6.6	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	485	7	2	3	4.4	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL43860	175694	0	None	-575	7	Human	6.6	pKi	=	6.6	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	485	7	2	3	4.4	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		21509921	111235	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	111235	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		3080926	162374	21	None	10	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/acs.jmedchem.9b02080
		CHEMBL404505	162374	21	None	10	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/acs.jmedchem.9b02080
		44330571	170778	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL420830	170778	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44330571	170778	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL420830	170778	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		9883506	77339	0	None	-1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	282	3	3	5	2.3	Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		CHEMBL194849	77339	0	None	-1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	282	3	3	5	2.3	Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		44371745	56063	0	None	11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	3	2.0	CCc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL156336	56063	0	None	11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	3	2.0	CCc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		13123527	108567	3	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300053	108567	3	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		13141184	172669	0	None	-17	2	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	376	1	0	3	5.6	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL424967	172669	0	None	-17	2	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	376	1	0	3	5.6	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		11198145	16587	2	None	-85	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL113830	16587	2	None	-85	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		16090597	148248	0	None	-5	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1nc2c(C)ccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL384318	148248	0	None	-5	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1nc2c(C)ccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		44328920	115418	0	None	-199	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	705	14	3	7	5.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL320736	115418	0	None	-199	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	705	14	3	7	5.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1	10.1016/s0960-894x(99)00484-9
		44325028	213750	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cccc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91297	213750	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cccc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44325079	213964	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	437	7	0	7	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL92496	213964	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	437	7	0	7	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		90644732	119495	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	1	2	3	1.0	CC1CN/C(=N/c2ccc3c(c2)OCO3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289545	119495	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	1	2	3	1.0	CC1CN/C(=N/c2ccc3c(c2)OCO3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304536	119495	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	1	2	3	1.0	CC1CN/C(=N/c2ccc3c(c2)OCO3)N1	10.1016/j.ejmech.2014.05.057
		11080	35858	79	None	1	6	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	35858	79	None	1	6	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL4549667	220777	5	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000720a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000720a ADRA2A	ChEMBL		None	None	None		CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21	10.6019/CHEMBL5212743
		CHEMBL4777443	220825	0	None	-11	14	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a ADRA2A	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
		24906241	199596	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		CHEMBL522151	199596	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		24906200	199935	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		CHEMBL523048	199935	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		135398737	7745	93	None	-26	90	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		38	7745	93	None	-26	90	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		722	7745	93	None	-26	90	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		CHEMBL42	7745	93	None	-26	90	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		DB00363	7745	93	None	-26	90	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		126225	101751	5	None	-10	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	263	1	0	2	4.2	C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		CHEMBL25467	101751	5	None	-10	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	263	1	0	2	4.2	C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		45487089	204419	0	None	10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	204	2	1	3	2.0	Cc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		CHEMBL570863	204419	0	None	10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	204	2	1	3	2.0	Cc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		10082076	20632	0	None	9	3	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1195953	20632	0	None	9	3	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL555637	20632	0	None	9	3	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		12841592	120271	2	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	237	1	1	5	0.8	Clc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL331981	120271	2	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	237	1	1	5	0.8	Clc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL538788	120271	2	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	237	1	1	5	0.8	Clc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		9809007	179343	8	None	-1905	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		CHEMBL448620	179343	8	None	-1905	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		9884781	45448	1	None	1	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	350	3	0	4	3.0	c1ccc2c(c1)CC(CN1CCN(c3ccc4c(c3)OCCO4)CC1)C2	10.1021/acs.jmedchem.7b00151
		CHEMBL146556	45448	1	None	1	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	350	3	0	4	3.0	c1ccc2c(c1)CC(CN1CCN(c3ccc4c(c3)OCCO4)CC1)C2	10.1021/acs.jmedchem.7b00151
		11624518	207122	3	None	-18	6	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	352	4	0	4	3.8	Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1	10.1016/j.ejmech.2012.08.011
		CHEMBL597601	207122	3	None	-18	6	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	352	4	0	4	3.8	Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1	10.1016/j.ejmech.2012.08.011
		415628	214971	95	None	-2	5	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	196	1	1	2	1.8	Clc1ccccc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL9841	214971	95	None	-2	5	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	196	1	1	2	1.8	Clc1ccccc1N1CCNCC1	10.1021/jm00366a007
		2389	10104	118	None	-37	66	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		5073	10104	118	None	-37	66	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		96	10104	118	None	-37	66	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		CHEMBL85	10104	118	None	-37	66	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		DB00734	10104	118	None	-37	66	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		10220232	106497	6	None	1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm990569e
		CHEMBL284795	106497	6	None	1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm990569e
		6761	74574	19	None	-6	18	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	74574	19	None	-6	18	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		44324765	118345	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328114	118345	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		10220232	106497	6	None	-1	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm000128r
		CHEMBL284795	106497	6	None	-1	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm000128r
		23292293	64941	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	244	2	1	2	3.0	Clc1cccc2ccc(CC3CN=CN3)cc12	10.1021/jm001040g
		CHEMBL168168	64941	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	244	2	1	2	3.0	Clc1cccc2ccc(CC3CN=CN3)cc12	10.1021/jm001040g
		44314200	109729	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
		CHEMBL306377	109729	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
		11948707	172946	0	None	-616	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity to alpha 2A adrenergic receptor by radioligand binding assayBinding affinity to alpha 2A adrenergic receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		CHEMBL426317	172946	0	None	-616	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity to alpha 2A adrenergic receptor by radioligand binding assayBinding affinity to alpha 2A adrenergic receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		11393666	199765	0	None	-6456	19	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	199765	0	None	-6456	19	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	199765	0	None	-6456	19	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		44401194	78070	0	None	-33	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL195706	78070	0	None	-33	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		9815610	106709	19	None	-13	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		CHEMBL286246	106709	19	None	-13	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		9815610	106709	19	None	13	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		CHEMBL286246	106709	19	None	13	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		5280953	104137	109	None	-3	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
		CHEMBL269538	104137	109	None	-3	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
		1752	52535	59	None	-2	5	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		CHEMBL153062	52535	59	None	-2	5	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		44438152	100383	0	None	-134	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	10.1016/j.bmcl.2006.12.094
		CHEMBL246639	100383	0	None	-134	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	10.1016/j.bmcl.2006.12.094
		2286	9957	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	9957	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	9957	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	9957	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	9957	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		24906242	194026	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2c(cccc2-c2ccccc2)O1	10.1021/jm800250z
		CHEMBL492647	194026	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2c(cccc2-c2ccccc2)O1	10.1021/jm800250z
		10073773	167902	16	None	-1288	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 minsDisplacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 mins	ChEMBL	477	5	0	6	3.4	COc1ccc2c(c1)c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccccc1Br	10.1021/acs.jmedchem.6b01662
		CHEMBL4082473	167902	16	None	-1288	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 minsDisplacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 mins	ChEMBL	477	5	0	6	3.4	COc1ccc2c(c1)c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccccc1Br	10.1021/acs.jmedchem.6b01662
		CHEMBL4117187	167902	16	None	-1288	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 minsDisplacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 mins	ChEMBL	477	5	0	6	3.4	COc1ccc2c(c1)c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccccc1Br	10.1021/acs.jmedchem.6b01662
		10042547	83076	5	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	334	1	1	2	3.9	CC1CCC(Nc2ccc(I)cc2Cl)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL2058635	83076	5	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	334	1	1	2	3.9	CC1CCC(Nc2ccc(I)cc2Cl)=N1	10.1016/j.bmc.2012.06.008
		155546767	180418	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	456	8	0	7	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4534152	180418	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	456	8	0	7	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL1458880	44624	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		3778834	108097	78	None	144	2	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	208	2	1	5	0.4	O=[N+]([O-])c1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL296653	108097	78	None	144	2	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	208	2	1	5	0.4	O=[N+]([O-])c1cccnc1N1CCNCC1	10.1021/jm00366a007
		44324725	213596	0	None	-13	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	451	8	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL90419	213596	0	None	-13	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	451	8	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		12114850	20020	0	None	57	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	704	5	6	6	4.2	O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1191424	20020	0	None	57	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	704	5	6	6	4.2	O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL542520	20020	0	None	57	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	704	5	6	6	4.2	O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		44269122	104885	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm800250z
		CHEMBL273485	104885	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm800250z
		45487144	204480	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.7	CC(OC1=NCCN1)c1ccccc1	10.1021/jm901262f
		CHEMBL571314	204480	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.7	CC(OC1=NCCN1)c1ccccc1	10.1021/jm901262f
		44269122	104885	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL273485	104885	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm100977d
		146025727	178464	0	None	-97	27	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	178464	0	None	-97	27	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		90644746	119499	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	265	2	3	1	4.0	N=C(Nc1ccccc1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289521	119499	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	265	2	3	1	4.0	N=C(Nc1ccccc1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304553	119499	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	265	2	3	1	4.0	N=C(Nc1ccccc1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		90644734	119496	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	4	2	3	2.6	CCOc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289546	119496	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	4	2	3	2.6	CCOc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304537	119496	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	4	2	3	2.6	CCOc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL4576555	220796	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		44312198	211368	0	None	1	4	Human	4.6	pKi	=	4.6	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	292	1	1	5	2.2	Brc1c(NC2=NCCO2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL73164	211368	0	None	1	4	Human	4.6	pKi	=	4.6	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	292	1	1	5	2.2	Brc1c(NC2=NCCO2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL4576555	220796	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		CHEMBL4576555	220796	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000705a ADRA2A	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
		9926143	120303	1	None	-467	4	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptorCompound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptor	ChEMBL	294	6	2	4	3.0	O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1	10.1021/jm990266k
		CHEMBL332154	120303	1	None	-467	4	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptorCompound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptor	ChEMBL	294	6	2	4	3.0	O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1	10.1021/jm990266k
		44401041	77262	0	None	-63	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL194659	77262	0	None	-63	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		3080926	162374	21	None	10	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/ml400232p
		CHEMBL404505	162374	21	None	10	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/ml400232p
		44579186	188755	0	None	-8	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	474	8	1	7	3.1	O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		CHEMBL478026	188755	0	None	-8	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	474	8	1	7	3.1	O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		9815633	106411	3	None	-6	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		CHEMBL284213	106411	3	None	-6	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		9815633	106411	3	None	6	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		CHEMBL284213	106411	3	None	6	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		11346584	143762	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL374584	143762	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm061487a
		11346584	143762	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL374584	143762	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm0408215
		11346584	143762	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL374584	143762	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		10266538	123749	2	None	1	2	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2ncc(Br)n3ccnc23)CC1	10.1021/jm00099a012
		CHEMBL338704	123749	2	None	1	2	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2ncc(Br)n3ccnc23)CC1	10.1021/jm00099a012
		1971	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		9828476	213703	0	None	-1202	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	532	9	2	7	5.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL91022	213703	0	None	-1202	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	532	9	2	7	5.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		162265	209053	22	None	-12	44	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	10.1021/jm030551a
		4786	209053	22	None	-12	44	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	10.1021/jm030551a
		CHEMBL61006	209053	22	None	-12	44	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	10.1021/jm030551a
		73346042	98609	5	None	-27542	17	Human	5.6	pKi	=	5.6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		CHEMBL2413153	98609	5	None	-27542	17	Human	5.6	pKi	=	5.6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		4211	64596	83	None	-1	4	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		CHEMBL1670	64596	83	None	-1	4	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		1028	7079	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		139148732	7079	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		479	7079	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		5816	7079	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		CHEMBL679	7079	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		DB00668	7079	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		10176567	109577	3	None	-10	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		CHEMBL30534	109577	3	None	-10	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		10176567	109577	3	None	10	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		CHEMBL30534	109577	3	None	10	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		126720252	171454	0	None	12	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4216870	171454	0	None	12	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		16655023	114218	2	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	114218	2	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		44292232	108098	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		CHEMBL296660	108098	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		2389	10104	118	None	-77	66	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		5073	10104	118	None	-77	66	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		96	10104	118	None	-77	66	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		CHEMBL85	10104	118	None	-77	66	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		DB00734	10104	118	None	-77	66	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		57345625	77954	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	224	3	1	3	2.1	CC(Oc1ccccc1Cl)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956191	77954	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	224	3	1	3	2.1	CC(Oc1ccccc1Cl)C1=NCCN1	10.1016/j.bmc.2012.01.035
		44574105	185587	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	305	5	1	4	1.3	CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
		CHEMBL469127	185587	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	305	5	1	4	1.3	CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
		24906202	193996	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		CHEMBL492444	193996	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		11380133	176146	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccncc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL442045	176146	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccncc1)C1=NCCN1	10.1021/jm0408215
		44456400	19606	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	19606	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	19606	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	19606	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		13091268	84999	0	None	-3090	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL210578	84999	0	None	-3090	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		24906159	194184	12	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
		CHEMBL493675	194184	12	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
		11203101	78458	0	None	-44	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	515	7	3	5	4.1	O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1	10.1016/j.bmcl.2005.03.116
		CHEMBL196451	78458	0	None	-44	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	515	7	3	5	4.1	O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1	10.1016/j.bmcl.2005.03.116
		11811395	211480	0	None	-2	4	Human	5.5	pKi	=	5.5	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	281	5	2	5	1.3	CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL74071	211480	0	None	-2	4	Human	5.5	pKi	=	5.5	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	281	5	2	5	1.3	CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		11777109	123745	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	254	0	1	2	2.9	Clc1cc(Cl)c2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL338683	123745	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	254	0	1	2	2.9	Clc1cc(Cl)c2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		9837106	110934	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		CHEMBL30955	110934	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		44330427	170154	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL419336	170154	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		9837106	110934	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		CHEMBL30955	110934	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		102	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		3659	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		8969	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		CHEMBL15245	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		DB01392	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		16655023	114218	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	114218	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		102	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		3659	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		8969	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		CHEMBL15245	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		DB01392	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		102	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		3659	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		8969	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		CHEMBL15245	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		DB01392	10899	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		12576	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		71310	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		CHEMBL353972	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		DB11481	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		10585356	127388	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	1	1	2	2.2	C1=NC[C@@H](C2C[C@@]23CCc2ccccc2C3)N1	10.1021/jm001040g
		135433755	127388	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	1	1	2	2.2	C1=NC[C@@H](C2C[C@@]23CCc2ccccc2C3)N1	10.1021/jm001040g
		CHEMBL354611	127388	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	1	1	2	2.2	C1=NC[C@@H](C2C[C@@]23CCc2ccccc2C3)N1	10.1021/jm001040g
		78114676	176620	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	402	6	0	6	3.3	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4439953	176620	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	402	6	0	6	3.3	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		13123529	108640	0	None	-	1	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300628	108640	0	None	-	1	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		49781006	24012	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	240	3	1	2	2.9	CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256565	24012	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	240	3	1	2	2.9	CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		136	10065	32	None	-12	16	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		223	10065	32	None	-12	16	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		643606	10065	32	None	-12	16	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		CHEMBL10347	10065	32	None	-12	16	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		16655023	114218	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	114218	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		16655023	114218	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL318235	114218	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		499	10849	18	None	-13	14	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		5685	10849	18	None	-13	14	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		CHEMBL25554	10849	18	None	-13	14	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		2389	10104	118	None	-77	66	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	10104	118	None	-77	66	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	10104	118	None	-77	66	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	10104	118	None	-77	66	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	10104	118	None	-77	66	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		2803	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		516	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		704	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		CHEMBL134	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		DB00575	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		2803	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		516	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		704	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		CHEMBL134	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		DB00575	7742	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		49781887	23916	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		CHEMBL1255617	23916	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		9990389	127210	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	2	1.8	C1=NCC(CC2Cc3ccccc3C2)N1	10.1021/jm001040g
		CHEMBL353843	127210	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	2	1.8	C1=NCC(CC2Cc3ccccc3C2)N1	10.1021/jm001040g
		49781007	24013	0	None	-2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	4	1	2	3.3	CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256566	24013	0	None	-2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	4	1	2	3.3	CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		240	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		2769	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		44279790	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		660	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		CHEMBL1729	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		CHEMBL560739	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		DB00604	7731	43	None	-3	25	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		44324972	170151	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL419316	170151	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		9971924	191005	0	None	3	3	Human	7.5	pKi	=	7.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL48341	191005	0	None	3	3	Human	7.5	pKi	=	7.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		13123531	195020	0	None	-	1	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		CHEMBL49953	195020	0	None	-	1	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		9953974	84608	0	None	-24	3	Human	5.5	pKi	=	5.5	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		CHEMBL2092927	84608	0	None	-24	3	Human	5.5	pKi	=	5.5	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		7059292	83075	7	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	1	1	2	2.9	Clc1ccccc1NC1=NCCC1	10.1016/j.bmc.2012.06.008
		CHEMBL2058633	83075	7	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	1	1	2	2.9	Clc1ccccc1NC1=NCCC1	10.1016/j.bmc.2012.06.008
		9894818	105701	0	None	-83	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL279436	105701	0	None	-83	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		44401042	131607	0	None	-81	9	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL364270	131607	0	None	-81	9	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		11225732	100432	0	None	-16	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL246852	100432	0	None	-16	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		10198248	194228	40	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	213	1	2	5	1.0	c1cnc2cc(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		CHEMBL49395	194228	40	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	213	1	2	5	1.0	c1cnc2cc(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		11199581	143337	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1	10.1021/jm0408215
		CHEMBL373830	143337	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1	10.1021/jm0408215
		9944467	16023	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	2	2	2	3.4	O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F	10.1021/jm030551a
		CHEMBL110751	16023	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	2	2	2	3.4	O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F	10.1021/jm030551a
		9794524	211622	2	None	10	3	Human	7.5	pKi	=	7.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	225	2	2	4	2.4	Cc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		CHEMBL75491	211622	2	None	10	3	Human	7.5	pKi	=	7.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	225	2	2	4	2.4	Cc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		10946567	23241	0	None	-25	6	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	265	1	0	2	4.1	CCc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		CHEMBL123448	23241	0	None	-25	6	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	265	1	0	2	4.1	CCc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		15463615	127142	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	246	2	1	2	3.1	Clc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		CHEMBL353200	127142	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	246	2	1	2	3.1	Clc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		44371864	57915	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL157955	57915	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		13141183	168742	1	None	-15	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	310	0	0	2	4.6	CN1CCC(=C2c3cc(Cl)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL415761	168742	1	None	-15	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	310	0	0	2	4.6	CN1CCC(=C2c3cc(Cl)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		10045088	87363	0	None	-407	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1CO	10.1021/jm060262x
		CHEMBL214996	87363	0	None	-407	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1CO	10.1021/jm060262x
		16090631	89166	0	None	-630	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.5	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C(C)O	10.1021/jm060262x
		CHEMBL217253	89166	0	None	-630	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.5	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C(C)O	10.1021/jm060262x
		10632290	211525	5	None	2	3	Human	5.5	pKi	=	5.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	211	2	2	4	2.1	c1c[nH]c(Nc2ccc3nccnc3c2)n1	10.1021/jm9605142
		CHEMBL74449	211525	5	None	2	3	Human	5.5	pKi	=	5.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	211	2	2	4	2.1	c1c[nH]c(Nc2ccc3nccnc3c2)n1	10.1021/jm9605142
		3191	109635	97	None	-8	25	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-8	25	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		122295	16640	7	None	-9	9	Rat	6.5	pKi	=	6.5	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		CHEMBL114166	16640	7	None	-9	9	Rat	6.5	pKi	=	6.5	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		72947315	99264	0	None	-3	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	4	1.6	c1ccc(OC2CC2)c(OCC2=NCCN2)c1	10.1021/ml400232p
		CHEMBL2431280	99264	0	None	-3	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	4	1.6	c1ccc(OC2CC2)c(OCC2=NCCN2)c1	10.1021/ml400232p
		44456400	19606	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	19606	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	19606	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	19606	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		57400959	77963	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956200	77963	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		10337773	108362	0	None	-79	10	Human	4.5	pKi	=	4.5	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL298612	108362	0	None	-79	10	Human	4.5	pKi	=	4.5	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		6424833	105948	101	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	178	1	1	3	1.2	O=[N+]([O-])c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		CHEMBL281289	105948	101	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	178	1	1	3	1.2	O=[N+]([O-])c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		10584556	214773	4	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	210	2	1	3	1.6	O=[N+]([O-])c1ccc2c(c1)CNC(CF)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL97282	214773	4	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	210	2	1	3	1.6	O=[N+]([O-])c1ccc2c(c1)CNC(CF)C2	10.1016/j.bmcl.2004.12.013
		3930	8932	43	None	-112	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	368	3	1	4	4.9	CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2	10.1021/jm060262x
		540335	8932	43	None	-112	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	368	3	1	4	4.9	CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2	10.1021/jm060262x
		CHEMBL106525	8932	43	None	-112	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	368	3	1	4	4.9	CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2	10.1021/jm060262x
		132075278	169423	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		CHEMBL4169752	169423	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		44415689	145887	0	None	-363	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL378669	145887	0	None	-363	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11385652	85711	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	460	6	0	6	3.7	CCOC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112975	85711	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	460	6	0	6	3.7	CCOC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		118717248	121902	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
		CHEMBL3343699	121902	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
		4038180	6992	14	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1007/s00044-004-0020-z
		480	6992	14	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1007/s00044-004-0020-z
		CHEMBL109783	6992	14	None	-3	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1007/s00044-004-0020-z
		4038180	6992	14	None	-3	8	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm030551a
		480	6992	14	None	-3	8	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm030551a
		CHEMBL109783	6992	14	None	-3	8	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm030551a
		11186227	91497	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL222798	91497	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1	10.1021/jm0408215
		13141187	137494	0	None	-9	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	378	1	0	3	5.2	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368475	137494	0	None	-9	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	378	1	0	3	5.2	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		9809007	179343	8	None	-1905	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		CHEMBL448620	179343	8	None	-1905	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		162658038	187925	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	530	10	5	13	0.4	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4760727	187925	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	530	10	5	13	0.4	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		70788951	33928	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1366	33928	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		90644726	119485	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	2	2	2	1.3	CC1CN/C(=N/c2ccc(N(C)C)cc2)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289542	119485	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	2	2	2	1.3	CC1CN/C(=N/c2ccc(N(C)C)cc2)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304469	119485	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	2	2	2	1.3	CC1CN/C(=N/c2ccc(N(C)C)cc2)N1	10.1016/j.ejmech.2014.05.057
		155539605	179624	0	None	-14	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assayDisplacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4514672	179624	0	None	-14	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assayDisplacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		8447	195728	84	None	-4	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	195728	84	None	-4	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		11199593	143977	0	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	1	3	3.8	CC(Sc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL374954	143977	0	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	1	3	3.8	CC(Sc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		44288769	107925	0	None	-3090	7	Human	5.5	pKi	=	5.5	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	542	7	1	4	4.5	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL295395	107925	0	None	-3090	7	Human	5.5	pKi	=	5.5	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	542	7	1	4	4.5	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		10176433	27420	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	186	0	1	2	1.5	C1=NCC2(CCc3ccccc3C2)N1	10.1021/jm00020a021
		CHEMBL130853	27420	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	186	0	1	2	1.5	C1=NCC2(CCc3ccccc3C2)N1	10.1021/jm00020a021
		135398737	7745	93	None	-26	90	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	7745	93	None	-26	90	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	7745	93	None	-26	90	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	7745	93	None	-26	90	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	7745	93	None	-26	90	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		44325027	213853	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cnc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91824	213853	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cnc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		45487958	205170	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.5	Cc1ccccc1COC1=NCCN1	10.1021/jm901262f
		CHEMBL576819	205170	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.5	Cc1ccccc1COC1=NCCN1	10.1021/jm901262f
		10376607	20132	0	None	1	2	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cnc(N2CCNCC2)c2ncc(C)n12	10.1021/jm00099a012
		CHEMBL1192423	20132	0	None	1	2	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cnc(N2CCNCC2)c2ncc(C)n12	10.1021/jm00099a012
		CHEMBL543653	20132	0	None	1	2	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cnc(N2CCNCC2)c2ncc(C)n12	10.1021/jm00099a012
		10332138	16331	3	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	246	1	1	3	2.2	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)(F)F)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL112351	16331	3	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	246	1	1	3	2.2	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)(F)F)C2	10.1016/j.bmcl.2004.12.013
		5226	103838	31	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	212	1	2	3	-0.0	NS(=O)(=O)c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		CHEMBL26717	103838	31	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	212	1	2	3	-0.0	NS(=O)(=O)c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		75201901	173204	19	None	-251	24	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	173204	19	None	-251	24	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		213	10625	55	None	-10	43	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	10625	55	None	-10	43	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	10625	55	None	-10	43	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	10625	55	None	-10	43	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	10625	55	None	-10	43	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		9798466	141056	1	None	-44	6	Rat	6.5	pKi	=	6.5	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		CHEMBL37170	141056	1	None	-44	6	Rat	6.5	pKi	=	6.5	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		14004037	60545	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL160388	60545	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		36324	33896	76	None	-	1	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		CHEMBL1365675	33896	76	None	-	1	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		14004037	60545	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL160388	60545	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		46869265	23029	0	None	-16	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		CHEMBL1224527	23029	0	None	-16	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		1548953	214458	27	None	-1	17	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	214458	27	None	-1	17	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		9895326	213806	0	None	-331	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	12	3	6	5.7	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1	10.1021/jm980077m
		CHEMBL91550	213806	0	None	-331	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	12	3	6	5.7	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1	10.1021/jm980077m
		57345628	77958	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1956195	77958	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		57345628	77958	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956195	77958	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		68712	107114	60	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL289480	107114	60	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		57345628	77958	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		CHEMBL1956195	77958	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		11608298	71850	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	228	2	1	3	1.9	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)F)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL182376	71850	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	228	2	1	3	1.9	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)F)C2	10.1016/j.bmcl.2004.12.013
		16090634	89069	0	None	-4	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	296	3	1	4	3.2	Cc1cncc(C)c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		CHEMBL217180	89069	0	None	-4	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	296	3	1	4	3.2	Cc1cncc(C)c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		3072540	89190	13	None	-97	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	382	4	1	4	5.3	CCN1CCN(c2ccc(Nc3c4ccccc4nc4ccccc34)cc2)CC1	10.1021/jm060262x
		CHEMBL217366	89190	13	None	-97	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	382	4	1	4	5.3	CCN1CCN(c2ccc(Nc3c4ccccc4nc4ccccc34)cc2)CC1	10.1021/jm060262x
		9817256	211017	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		CHEMBL71001	211017	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		44390749	70684	0	None	-199	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	607	11	3	6	5.3	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL180561	70684	0	None	-199	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	607	11	3	6	5.3	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1016/s0960-894x(99)00484-9
		441383	27105	57	None	-2	17	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	27105	57	None	-2	17	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		94459	71048	127	None	64	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	163	1	1	3	0.5	c1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		CHEMBL18094	71048	127	None	64	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	163	1	1	3	0.5	c1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		3086326	211310	22	None	1	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL72753	211310	22	None	1	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		11173568	91416	0	None	8	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL222371	91416	0	None	8	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
		10083242	20606	1	None	5	3	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	2	1	5	1.3	CC(C)c1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1195814	20606	1	None	5	3	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	2	1	5	1.3	CC(C)c1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL555391	20606	1	None	5	3	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	2	1	5	1.3	CC(C)c1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		3584	10549	64	None	-251	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		5401	10549	64	None	-251	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		7302	10549	64	None	-251	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		CHEMBL611	10549	64	None	-251	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		DB01162	10549	64	None	-251	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		9894818	105701	0	None	-83	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL279436	105701	0	None	-83	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		155547141	180398	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	518	9	0	7	5.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(Oc4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4533687	180398	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	518	9	0	7	5.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(Oc4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		56964794	80839	0	None	-19	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	418	3	0	5	4.8	Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2	10.1021/jm2013419
		CHEMBL2022272	80839	0	None	-19	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	418	3	0	5	4.8	Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2	10.1021/jm2013419
		12774559	196388	0	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		CHEMBL51479	196388	0	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		44574080	195725	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	264	2	0	4	2.6	Cn1cc(-c2ccccc2[C@@H]2Cc3nccn3C2)cn1	10.1016/j.bmcl.2009.03.166
		CHEMBL508084	195725	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	264	2	0	4	2.6	Cn1cc(-c2ccccc2[C@@H]2Cc3nccn3C2)cn1	10.1016/j.bmcl.2009.03.166
		44312036	211344	1	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
		CHEMBL72995	211344	1	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
		57401787	78028	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	308	3	1	4	2.3	c1ccc(C2(c3ccccc3)COCC(C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956906	78028	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	308	3	1	4	2.3	c1ccc(C2(c3ccccc3)COCC(C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL5094181	222259	22	None	-12	5	Human	5.4	pKi	=	5.4	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		CHEMBL5094181	222259	22	None	-12	5	Human	5.4	pKi	=	5.4	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		90644724	119487	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	3	3	2	3.2	CN(C)c1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289522	119487	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	3	3	2	3.2	CN(C)c1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304483	119487	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	3	3	2	3.2	CN(C)c1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		10221005	211101	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	4	2	5	0.8	Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		CHEMBL71479	211101	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	4	2	5	0.8	Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		10682720	211941	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	259	3	2	3	3.8	COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C	10.1021/jm9605142
		CHEMBL78190	211941	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	259	3	2	3	3.8	COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C	10.1021/jm9605142
		12981867	127135	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		CHEMBL353139	127135	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		49836308	25556	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1278084	25556	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		11651319	188407	27	None	17	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cnccc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL47740	188407	27	None	17	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cnccc1N1CCNCC1	10.1021/jm00366a007
		21584368	206631	3	None	4	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL59441	206631	3	None	4	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1016/j.bmcl.2004.12.013
		164585473	191341	0	None	-7	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to alpha2a (unknown origin)Binding affinity to alpha2a (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4848380	191341	0	None	-7	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to alpha2a (unknown origin)Binding affinity to alpha2a (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		10841387	106394	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		CHEMBL284103	106394	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		11079593	210894	0	None	1	4	Human	6.4	pKi	=	6.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70326	210894	0	None	1	4	Human	6.4	pKi	=	6.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		10841387	106394	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL284103	106394	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		153287574	182026	0	None	-5	10	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4572167	182026	0	None	-5	10	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		24906203	193997	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		CHEMBL492445	193997	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		57384051	78024	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2CO[C@@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956902	78024	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2CO[C@@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		136274357	85719	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	412	4	1	5	3.8	c1ccc2c(c1)NC[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		CHEMBL2112984	85719	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	412	4	1	5	3.8	c1ccc2c(c1)NC[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		49864336	22389	0	None	11	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	453	9	1	5	3.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221545	22389	0	None	11	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	453	9	1	5	3.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		13507646	126392	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL346492	126392	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		13507646	126392	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL346492	126392	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		1593	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		30668	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		9868	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		CHEMBL17860	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		DB04948	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		102	10899	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		3659	10899	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		8969	10899	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		CHEMBL15245	10899	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		DB01392	10899	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		78114881	178560	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	288	5	0	6	0.9	CCOP(=O)(OCC)C1N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4467833	178560	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	288	5	0	6	0.9	CCOP(=O)(OCC)C1N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		42273326	22388	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	403	7	1	4	3.8	COc1ccccc1N1CCN(CCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221544	22388	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	403	7	1	4	3.8	COc1ccccc1N1CCN(CCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		136	10065	32	None	-3	16	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		223	10065	32	None	-3	16	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		643606	10065	32	None	-3	16	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		CHEMBL10347	10065	32	None	-3	16	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		42388639	194833	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL497749	194833	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		11191321	69759	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	503	6	0	7	4.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C(C)(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL178588	69759	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	503	6	0	7	4.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C(C)(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		2142	9870	58	None	-2	37	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		4920903	9870	58	None	-2	37	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		502	9870	58	None	-2	37	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		5775	9870	58	None	-2	37	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		CHEMBL597	9870	58	None	-2	37	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		DB00692	9870	58	None	-2	37	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		44404326	140302	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	283	3	2	5	2.7	Cc1ccc(N(NC2=NCCO2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		CHEMBL370818	140302	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	283	3	2	5	2.7	Cc1ccc(N(NC2=NCCO2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		135	9310	43	None	-4	56	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		1796	9310	43	None	-4	56	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		4184	9310	43	None	-4	56	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		CHEMBL6437	9310	43	None	-4	56	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		DB06148	9310	43	None	-4	56	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		9795515	211599	0	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	273	3	2	3	4.1	COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C	10.1021/jm9605142
		CHEMBL75257	211599	0	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	273	3	2	3	4.1	COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C	10.1021/jm9605142
		2585	7590	103	None	-28	22	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	7590	103	None	-28	22	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	7590	103	None	-28	22	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	7590	103	None	-28	22	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	7590	103	None	-28	22	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		155515982	176789	0	None	-1584	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4442460	176789	0	None	-1584	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		44438147	100264	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL246228	100264	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	10.1016/j.bmcl.2006.12.094
		10032383	116887	0	None	-389	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	666	15	4	8	4.2	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1	10.1016/s0960-894x(99)00484-9
		136680387	116887	0	None	-389	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	666	15	4	8	4.2	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL323579	116887	0	None	-389	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	666	15	4	8	4.2	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1	10.1016/s0960-894x(99)00484-9
		73213196	111237	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adrenergic alpha 2A receptor (unknown origin)Binding affinity to adrenergic alpha 2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		CHEMBL3104093	111237	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adrenergic alpha 2A receptor (unknown origin)Binding affinity to adrenergic alpha 2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		73213196	111237	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	111237	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		44401105	76351	0	None	-45	9	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193435	76351	0	None	-45	9	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		73213196	111237	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	111237	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		11109088	210959	0	None	-8	6	Human	7.4	pKi	=	7.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70751	210959	0	None	-8	6	Human	7.4	pKi	=	7.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
		70695474	84447	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL2089156	84447	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		11173544	173040	0	None	6	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL426900	173040	0	None	6	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1	10.1021/jm0408215
		70695474	84447	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		CHEMBL2089156	84447	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		4209	9937	75	None	-794	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	9937	75	None	-794	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	9937	75	None	-794	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	9937	75	None	-794	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	9937	75	None	-794	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	9937	75	None	-794	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		9885114	126382	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		CHEMBL346389	126382	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		9885114	126382	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/acs.jmedchem.7b00151
		CHEMBL346389	126382	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/acs.jmedchem.7b00151
		57326584	80840	0	None	-4	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	396	1	0	5	4.9	Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2	10.1021/jm2013419
		CHEMBL2022273	80840	0	None	-4	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	396	1	0	5	4.9	Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2	10.1021/jm2013419
		24906196	194025	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	261	6	1	5	1.8	CCO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		CHEMBL492639	194025	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	261	6	1	5	1.8	CCO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		11500225	107978	61	None	38	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	289	1	1	3	1.1	Ic1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL295764	107978	61	None	38	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	289	1	1	3	1.1	Ic1cccnc1N1CCNCC1	10.1021/jm00366a007
		44438167	155749	0	None	-52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL394218	155749	0	None	-52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	10.1016/j.bmcl.2006.12.094
		1265	7729	60	None	-75	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		6422124	7729	60	None	-75	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		CHEMBL14638	7729	60	None	-75	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		13123533	201688	1	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		CHEMBL541208	201688	1	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		62381256	119543	2	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	5	3	2	2.4	CCCNC(=N)Nc1ccc(OCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289535	119543	2	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	5	3	2	2.4	CCCNC(=N)Nc1ccc(OCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305460	119543	2	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	5	3	2	2.4	CCCNC(=N)Nc1ccc(OCC)cc1	10.1016/j.ejmech.2014.05.057
		13869716	167059	8	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	199	1	1	3	1.5	Cn1c(C2=NCCN2)cc2ccccc21	10.1021/acs.jmedchem.9b02080
		CHEMBL41103	167059	8	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	199	1	1	3	1.5	Cn1c(C2=NCCN2)cc2ccccc21	10.1021/acs.jmedchem.9b02080
		71456239	85715	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	385	5	0	4	3.8	C1=C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112979	85715	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	385	5	0	4	3.8	C1=C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		13141185	67262	0	None	-9	2	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	356	0	0	2	4.3	CN1CCC(=C2c3cc(Br)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL175508	67262	0	None	-9	2	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	356	0	0	2	4.3	CN1CCC(=C2c3cc(Br)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		10401405	16449	16	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	279	0	1	1	3.0	FC(F)(F)C1Cc2ccc(Br)cc2CN1	10.1016/j.bmcl.2004.12.013
		CHEMBL112964	16449	16	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	279	0	1	1	3.0	FC(F)(F)C1Cc2ccc(Br)cc2CN1	10.1016/j.bmcl.2004.12.013
		2719	7704	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		5535	7704	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		607	7704	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		CHEMBL76	7704	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		DB00608	7704	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		45588795	119534	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	2	3	3	2.9	N=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289534	119534	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	2	3	3	2.9	N=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305316	119534	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	2	3	3	2.9	N=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		4098	39279	30	None	-13	11	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	39279	30	None	-13	11	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	39279	30	None	-13	11	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		49836304	25343	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276219	25343	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		70693375	84446	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL2089155	84446	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		49836304	25343	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276219	25343	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		49836305	25348	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276248	25348	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		70693375	84446	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		CHEMBL2089155	84446	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		9944409	14385	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	307	3	3	4	2.0	CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL108804	14385	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	307	3	3	4	2.0	CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		44579272	193874	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
		CHEMBL491420	193874	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
		10397358	181766	44	None	70	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	178	1	2	4	0.1	Nc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL45665	181766	44	None	70	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	178	1	2	4	0.1	Nc1cccnc1N1CCNCC1	10.1021/jm00366a007
		44579231	188346	0	None	-28	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	396	6	1	6	1.7	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1	10.1016/j.bmcl.2008.08.055
		CHEMBL476774	188346	0	None	-28	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	396	6	1	6	1.7	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1	10.1016/j.bmcl.2008.08.055
		135418497	69813	0	None	-1949	4	Human	6.4	pKi	=	6.4	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4NC(=O)N32)CC1	10.1021/jm970159v
		CHEMBL1788222	69813	0	None	-1949	4	Human	6.4	pKi	=	6.4	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4NC(=O)N32)CC1	10.1021/jm970159v
		2812	11551	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		10531532	213873	0	None	-51	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	594	9	2	7	6.0	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL91956	213873	0	None	-51	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	594	9	2	7	6.0	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		10199335	211526	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL74467	211526	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		49781008	24022	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	3	1	2	3.3	CC(C)O[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256608	24022	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	3	1	2	3.3	CC(C)O[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		11371902	148416	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL385310	148416	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
		11371902	148416	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL385310	148416	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		121938	148673	20	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	215	0	1	1	3.0	Clc1ccc2c(c1Cl)CNCCC2	10.1021/jm0205752
		CHEMBL38681	148673	20	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	215	0	1	1	3.0	Clc1ccc2c(c1Cl)CNCCC2	10.1021/jm0205752
		10436842	107032	0	None	-5754	7	Human	5.3	pKi	=	5.3	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.6	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL288772	107032	0	None	-5754	7	Human	5.3	pKi	=	5.3	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.6	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		57326586	80841	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	402	5	1	7	2.5	OCCOCCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		CHEMBL2022275	80841	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	402	5	1	7	2.5	OCCOCCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		44438165	173563	0	None	-48	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL428407	173563	0	None	-48	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	10.1016/j.bmcl.2006.12.094
		16007117	86811	0	None	-457	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212912	86811	0	None	-457	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415704	86934	0	None	-158	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213424	86934	0	None	-158	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		155538007	179134	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4475933	179134	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		3561	25849	39	None	-1	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	25849	39	None	-1	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		499	10849	18	None	-346	14	Rat	7.3	pKi	=	7.3	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		5685	10849	18	None	-346	14	Rat	7.3	pKi	=	7.3	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		CHEMBL25554	10849	18	None	-346	14	Rat	7.3	pKi	=	7.3	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		11300487	91777	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1	10.1021/jm0408215
		CHEMBL223830	91777	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1	10.1021/jm0408215
		10467319	210621	14	None	-9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity at alpha-2 adrenergic receptor of rat.Binding affinity at alpha-2 adrenergic receptor of rat.	ChEMBL	250	0	2	1	2.6	Brc1cccc2c3c([nH]c12)CNCC3	10.1016/j.bmcl.2003.11.078
		CHEMBL6857	210621	14	None	-9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity at alpha-2 adrenergic receptor of rat.Binding affinity at alpha-2 adrenergic receptor of rat.	ChEMBL	250	0	2	1	2.6	Brc1cccc2c3c([nH]c12)CNCC3	10.1016/j.bmcl.2003.11.078
		6455104	105262	6	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	172	2	1	2	1.7	C(=C/c1ccccc1)\C1=NCCN1	10.1021/acs.jmedchem.9b02080
		CHEMBL275970	105262	6	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	172	2	1	2	1.7	C(=C/c1ccccc1)\C1=NCCN1	10.1021/acs.jmedchem.9b02080
		15853467	214913	0	None	-141	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Alpha-2A adrenergic receptorBinding affinity against human Alpha-2A adrenergic receptor	ChEMBL	692	16	3	8	5.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1	10.1016/s0960-894x(99)00484-9
		CHEMBL98063	214913	0	None	-141	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Alpha-2A adrenergic receptorBinding affinity against human Alpha-2A adrenergic receptor	ChEMBL	692	16	3	8	5.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1	10.1016/s0960-894x(99)00484-9
		44574134	185283	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	269	2	0	4	3.0	Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL466634	185283	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	269	2	0	4	3.0	Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		44387798	173052	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	458	7	0	5	3.9	CC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(CCC/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL426959	173052	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	458	7	0	5	3.9	CC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(CCC/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		11108001	17644	2	None	-4	6	Human	7.3	pKi	=	7.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL117248	17644	2	None	-4	6	Human	7.3	pKi	=	7.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL540542	17644	2	None	-4	6	Human	7.3	pKi	=	7.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		44352207	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
		CHEMBL128168	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
		44352207	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL128168	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		44352207	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL128168	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		44352207	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL128168	25628	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		162674829	190053	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	513	11	5	11	1.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4796664	190053	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	513	11	5	11	1.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		164614469	191560	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	341	1	0	3	3.9	C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4851349	191560	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	341	1	0	3	3.9	C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		13149	9323	36	None	-77	17	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.9b01465
		3034396	9323	36	None	-77	17	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.9b01465
		CHEMBL299031	9323	36	None	-77	17	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.9b01465
		44269013	37115	1	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	218	5	1	3	2.0	CCCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		CHEMBL13917	37115	1	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	218	5	1	3	2.0	CCCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		45487962	204264	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	218	4	1	3	2.1	CCCc1ccccc1COC1=NCCN1	10.1021/jm901262f
		CHEMBL569933	204264	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	218	4	1	3	2.1	CCCc1ccccc1COC1=NCCN1	10.1021/jm901262f
		11776640	20318	0	None	2	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	3	1	5	1.1	CCCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1193824	20318	0	None	2	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	3	1	5	1.1	CCCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL545293	20318	0	None	2	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	3	1	5	1.1	CCCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		163198500	193177	3	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	371	1	0	3	3.2	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	10.1016/j.bmcl.2021.128008
		CHEMBL4875858	193177	3	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	371	1	0	3	3.2	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	10.1016/j.bmcl.2021.128008
		15407445	207057	2	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	192	1	1	3	1.6	CC1Cc2ccc([N+](=O)[O-])cc2CN1	10.1016/j.bmcl.2004.12.013
		CHEMBL59719	207057	2	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	192	1	1	3	1.6	CC1Cc2ccc([N+](=O)[O-])cc2CN1	10.1016/j.bmcl.2004.12.013
		132060743	169015	0	None	-1	13	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4163428	169015	0	None	-1	13	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		57395732	77966	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	342	5	1	3	4.8	CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956203	77966	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	342	5	1	3	4.8	CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		70696790	83074	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	3	1	3	1.5	CC1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL2058632	83074	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	3	1	3	1.5	CC1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		90644748	119512	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	4	4	2	3.6	CCNc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289520	119512	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	4	4	2	3.6	CCNc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304855	119512	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	4	4	2	3.6	CCNc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		155517797	176992	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	498	8	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC34CC5CC(CC(C5)C3)C4)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4445396	176992	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	498	8	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC34CC5CC(CC(C5)C3)C4)C(=O)C21	10.1021/acs.jmedchem.9b02080
		102	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		3659	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		8969	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		CHEMBL15245	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		DB01392	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		102	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		3659	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		8969	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		CHEMBL15245	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		DB01392	10899	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		191	7191	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	7191	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	7191	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	7191	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	7191	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		13298530	105848	20	None	97	2	Bovine	8.3	pKi	=	8.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	195	1	0	3	1.0	CN1CCN(c2ncccc2F)CC1	10.1021/jm00366a007
		CHEMBL280514	105848	20	None	97	2	Bovine	8.3	pKi	=	8.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	195	1	0	3	1.0	CN1CCN(c2ncccc2F)CC1	10.1021/jm00366a007
		44215744	214221	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL94129	214221	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		521	8186	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		5311068	8186	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		835	8186	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		CHEMBL778	8186	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		DB00633	8186	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		42267840	22376	2	None	4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	425	7	1	5	2.9	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221499	22376	2	None	4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	425	7	1	5	2.9	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		44330857	11166	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4OC)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL101361	11166	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4OC)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		294234	109670	3	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
		CHEMBL305928	109670	3	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
		31101	7516	40	None	-10	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	7516	40	None	-10	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	7516	40	None	-10	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	7516	40	None	-10	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	7516	40	None	-10	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		13123525	195977	0	None	-	1	Bovine	8.3	pKi	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		CHEMBL51131	195977	0	None	-	1	Bovine	8.3	pKi	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		44330598	214417	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL95218	214417	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		10220053	213699	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1016/s0960-894x(03)00525-0
		CHEMBL90997	213699	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1016/s0960-894x(03)00525-0
		10220053	213699	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1021/jm049619s
		CHEMBL90997	213699	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1021/jm049619s
		1343	8670	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		3519	8670	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		522	8670	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL862	8670	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		DB01018	8670	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		100	10577	58	None	-33	54	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	10577	58	None	-33	54	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	10577	58	None	-33	54	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	10577	58	None	-33	54	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	10577	58	None	-33	54	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		73291731	99266	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	3	2.4	CCCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		CHEMBL2431282	99266	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	3	2.4	CCCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		117590588	103299	35	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	10.1021/jm001040g
		14969	103299	35	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	10.1021/jm001040g
		CHEMBL262777	103299	35	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	10.1021/jm001040g
		24906199	194444	15	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
		CHEMBL495096	194444	15	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
		45487955	205089	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	232	4	1	3	2.7	CCCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		CHEMBL576078	205089	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	232	4	1	3	2.7	CCCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		2771431	195061	52	None	1	2	Bovine	6.3	pKi	=	6.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.8	Clc1cnc(N2CCNCC2)c(Cl)c1	10.1021/jm00366a007
		CHEMBL50016	195061	52	None	1	2	Bovine	6.3	pKi	=	6.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.8	Clc1cnc(N2CCNCC2)c(Cl)c1	10.1021/jm00366a007
		9923679	88537	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	332	3	1	4	4.0	Cc1cc(Nc2ccc(N3CCN(C)CC3)cc2)c2ccccc2n1	10.1021/jm060262x
		CHEMBL216399	88537	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	332	3	1	4	4.0	Cc1cc(Nc2ccc(N3CCN(C)CC3)cc2)c2ccccc2n1	10.1021/jm060262x
		162651072	186959	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	527	12	5	11	1.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4749263	186959	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	527	12	5	11	1.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		137641762	164878	0	None	-15	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	476	5	4	10	1.1	CCCNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.7b00141
		CHEMBL4086593	164878	0	None	-15	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	476	5	4	10	1.1	CCCNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.7b00141
		137643541	165210	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	448	3	4	10	0.3	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(C#Cc4ccc(Cl)s4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00141
		CHEMBL4090355	165210	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	448	3	4	10	0.3	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(C#Cc4ccc(Cl)s4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00141
		3158	63041	27	None	-3467	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	63041	27	None	-3467	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		10651080	112719	0	None	-57	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	9	3	6	4.7	CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL312871	112719	0	None	-57	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	9	3	6	4.7	CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		57398332	78022	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc(C2COC(C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956900	78022	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc(C2COC(C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		10916464	210932	0	None	-10	5	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70563	210932	0	None	-10	5	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1	10.1021/jm000542r
		44579184	197732	4	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		CHEMBL518592	197732	4	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		132060776	169181	0	None	-1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		CHEMBL4165863	169181	0	None	-1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		11820657	20216	1	None	6	2	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc(N3CCNCC3)c2n1	10.1021/jm00099a012
		CHEMBL1193017	20216	1	None	6	2	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc(N3CCNCC3)c2n1	10.1021/jm00099a012
		CHEMBL544354	20216	1	None	6	2	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc(N3CCNCC3)c2n1	10.1021/jm00099a012
		10036255	28131	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL131417	28131	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		10036256	30553	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL133579	30553	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		11277479	91525	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1	10.1021/jm0408215
		CHEMBL222973	91525	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1	10.1021/jm0408215
		10214826	11251	20	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	289	2	2	4	2.9	Brc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		CHEMBL1019	11251	20	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	289	2	2	4	2.9	Brc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		130442572	178687	0	None	-109	24	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	178687	0	None	-109	24	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		90644706	119520	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	269	3	3	2	3.3	N=C(NCc1ccco1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289531	119520	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	269	3	3	2	3.3	N=C(NCc1ccco1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304994	119520	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	269	3	3	2	3.3	N=C(NCc1ccco1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		4735	201894	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	201894	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	201894	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		3584	10549	64	None	-251	14	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		5401	10549	64	None	-251	14	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		7302	10549	64	None	-251	14	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		CHEMBL611	10549	64	None	-251	14	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		DB01162	10549	64	None	-251	14	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		10101373	19865	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	718	6	6	6	4.6	O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1190317	19865	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	718	6	6	6	4.6	O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL540594	19865	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	718	6	6	6	4.6	O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		24882007	19245	1	None	1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
		CHEMBL1186220	19245	1	None	1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
		49836301	25339	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276140	25339	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml400232p
		49836301	25339	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276140	25339	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/jm100977d
		49836301	25339	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml300064v
		CHEMBL1276140	25339	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml300064v
		16785637	188356	80	None	11	2	Bovine	5.3	pKi	=	5.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	206	2	2	4	-0.4	NC(=O)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL47688	188356	80	None	11	2	Bovine	5.3	pKi	=	5.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	206	2	2	4	-0.4	NC(=O)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		162664704	188990	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4783068	188990	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		73347825	99315	0	None	-3	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	311	5	1	3	2.9	COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2432046	99315	0	None	-3	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	311	5	1	3	2.9	COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC	10.1016/j.bmc.2013.07.045
		145973771	171498	0	None	-6	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4217398	171498	0	None	-6	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		448537	167029	89	None	-33	25	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	167029	89	None	-33	25	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		155521287	177357	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4450506	177357	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		487	10406	21	None	-1513	12	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		60602	10406	21	None	-1513	12	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		CHEMBL405355	10406	21	None	-1513	12	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		DB09239	10406	21	None	-1513	12	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		10059780	19731	0	None	6	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	2	1	5	0.7	CCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1189347	19731	0	None	6	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	2	1	5	0.7	CCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL538537	19731	0	None	6	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	2	1	5	0.7	CCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		289	7030	12	None	-47	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		9948320	7030	12	None	-47	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		CHEMBL1242950	7030	12	None	-47	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		2398	7741	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	7741	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	7741	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	7741	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	7741	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		162643475	188522	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to alpha 2A adrenoceptor (unknown origin)Binding affinity to alpha 2A adrenoceptor (unknown origin)	ChEMBL	283	1	0	2	4.3	C=C1CCN2Cc3ccc(OC)cc3[C@H]3CCCC[C@]32C1	10.1021/acs.jmedchem.0c01192
		CHEMBL4777306	188522	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to alpha 2A adrenoceptor (unknown origin)Binding affinity to alpha 2A adrenoceptor (unknown origin)	ChEMBL	283	1	0	2	4.3	C=C1CCN2Cc3ccc(OC)cc3[C@H]3CCCC[C@]32C1	10.1021/acs.jmedchem.0c01192
		15730	77893	80	None	-2	10	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	77893	80	None	-2	10	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		155521287	177357	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4450506	177357	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		57394788	78025	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956903	78025	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		10092819	23545	0	None	-51	11	Rat	7.3	pKi	=	7.3	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		CHEMBL124444	23545	0	None	-51	11	Rat	7.3	pKi	=	7.3	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		44424855	92229	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL226636	92229	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		518	10384	1	None	-3	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	299	0	0	2	3.8	CN1CCc2c3c(C1)c(Br)oc3ccc2Cl	10.1021/jm00019a001
		9839317	10384	1	None	-3	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	299	0	0	2	3.8	CN1CCc2c3c(C1)c(Br)oc3ccc2Cl	10.1021/jm00019a001
		CHEMBL123138	10384	1	None	-3	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	299	0	0	2	3.8	CN1CCc2c3c(C1)c(Br)oc3ccc2Cl	10.1021/jm00019a001
		49781005	23986	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256503	23986	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		6075	156887	42	None	-11	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	156887	42	None	-11	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		155548049	180476	0	None	-3	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2cccc(O)c2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		CHEMBL4535634	180476	0	None	-3	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2cccc(O)c2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		135559170	108837	0	None	-851	7	Human	6.3	pKi	=	6.3	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1	10.1021/jm970159v
		CHEMBL302021	108837	0	None	-851	7	Human	6.3	pKi	=	6.3	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1	10.1021/jm970159v
		3584	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		5401	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		7302	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		CHEMBL611	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		DB01162	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		9813756	15788	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	255	2	2	2	2.8	CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL109848	15788	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	255	2	2	2	2.8	CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		13123534	196232	1	None	-	1	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		CHEMBL51358	196232	1	None	-	1	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		2142	9870	58	None	-2	37	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		4920903	9870	58	None	-2	37	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		502	9870	58	None	-2	37	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		5775	9870	58	None	-2	37	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		CHEMBL597	9870	58	None	-2	37	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		DB00692	9870	58	None	-2	37	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		3584	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		5401	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		7302	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		CHEMBL611	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		DB01162	10549	64	None	-251	14	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		12613159	194105	11	None	-16	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL493054	194105	11	None	-16	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		11465618	109175	23	None	-2089	19	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	109175	23	None	-2089	19	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	109175	23	None	-2089	19	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		9816461	17491	7	None	-9	4	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL117094	17491	7	None	-9	4	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL544290	17491	7	None	-9	4	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		24906198	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		CHEMBL495095	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		57402717	77962	2	None	14	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	220	4	1	4	1.5	COc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956199	77962	2	None	14	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	220	4	1	4	1.5	COc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		24906198	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		CHEMBL495095	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		45487145	204438	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	4	1	3	2.5	C=CCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		CHEMBL570973	204438	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	4	1	3	2.5	C=CCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		24906198	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm100977d
		CHEMBL495095	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm100977d
		24906198	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml300064v
		CHEMBL495095	194443	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml300064v
		44329027	10940	0	None	-29	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	637	13	3	7	4.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL100045	10940	0	None	-29	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	637	13	3	7	4.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1	10.1016/s0960-894x(99)00484-9
		11097789	109775	1	None	-11	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL306792	109775	1	None	-11	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		2765	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		515	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		CHEMBL13852	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		DB09202	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		2765	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		515	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		CHEMBL13852	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		DB09202	7730	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		16090621	148353	0	None	-16	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	5	1	4	5.6	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1Cc1ccccc1	10.1021/jm060262x
		CHEMBL384925	148353	0	None	-16	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	5	1	4	5.6	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1Cc1ccccc1	10.1021/jm060262x
		1960	9632	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		439260	9632	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		505	9632	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		CHEMBL1437	9632	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		DB00368	9632	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		9906978	49485	2	None	-165	12	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL150161	49485	2	None	-165	12	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		6726	8063	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	8063	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	8063	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	8063	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	8063	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		150	9287	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	9287	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	9287	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	9287	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	9287	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		9859437	174801	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
		CHEMBL432155	174801	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
		49864360	22399	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	445	10	1	4	5.0	COc1ccccc1N1CCN(CCCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221593	22399	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	445	10	1	4	5.0	COc1ccccc1N1CCN(CCCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		11653915	130790	0	None	-1	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	296	4	2	5	2.6	COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
		CHEMBL362954	130790	0	None	-1	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	296	4	2	5	2.6	COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
		1209	8439	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		203	8439	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		3386	8439	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		CHEMBL41	8439	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		DB00472	8439	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		131829	211506	15	None	7	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
		CHEMBL74283	211506	15	None	7	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
		135477797	85707	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112971	85707	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		2435	7509	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		395	7509	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		520	7509	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		5386	7509	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		CHEMBL844	7509	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		DB00484	7509	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		10382537	210945	12	None	6	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL70676	210945	12	None	6	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		98358	126264	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL345349	126264	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		98358	126264	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL345349	126264	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		11361608	91520	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL222928	91520	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		11361608	91520	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL222928	91520	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm0408215
		11361608	91520	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL222928	91520	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		13141186	137469	0	None	-7	2	Bovine	6.2	pKi	=	6.2	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	312	0	0	2	4.2	CN1CCC(=C2c3cc(Cl)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368357	137469	0	None	-7	2	Bovine	6.2	pKi	=	6.2	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	312	0	0	2	4.2	CN1CCC(=C2c3cc(Cl)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		9851486	213478	0	None	-512	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	10	2	6	6.0	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL89685	213478	0	None	-512	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	10	2	6	6.0	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		155525779	177821	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.3	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4456882	177821	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.3	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		11771731	115023	2	None	-16	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL319706	115023	2	None	-16	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		134	9292	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	9292	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	9292	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	9292	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	9292	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		489	6933	28	None	-1778	12	Human	6.2	pKi	=	6.2	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	401	7	1	8	1.0	COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C	10.1021/jm00018a001
		5640	6933	28	None	-1778	12	Human	6.2	pKi	=	6.2	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	401	7	1	8	1.0	COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C	10.1021/jm00018a001
		CHEMBL420060	6933	28	None	-1778	12	Human	6.2	pKi	=	6.2	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	401	7	1	8	1.0	COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C	10.1021/jm00018a001
		10082625	20565	0	None	-4	3	Bovine	6.2	pKi	=	6.2	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cn2c(C)cnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL1195526	20565	0	None	-4	3	Bovine	6.2	pKi	=	6.2	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cn2c(C)cnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL554785	20565	0	None	-4	3	Bovine	6.2	pKi	=	6.2	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cn2c(C)cnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		2750	210840	76	None	-3	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-3	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		2351	10059	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	10059	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	10059	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	10059	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	10059	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		129211	10521	78	None	-120	16	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		2562	10521	78	None	-120	16	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		488	10521	78	None	-120	16	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		CHEMBL836	10521	78	None	-120	16	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		DB00706	10521	78	None	-120	16	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		2274	9947	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	9947	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	9947	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	9947	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	9947	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		10934575	211265	0	None	-3	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL72441	211265	0	None	-3	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
		10823140	127144	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	2	1	2	2.5	C1=NC[C@H](C[C@]23CCc4ccccc4C2C3)N1	10.1021/jm001040g
		136078488	127144	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	2	1	2	2.5	C1=NC[C@H](C[C@]23CCc4ccccc4C2C3)N1	10.1021/jm001040g
		CHEMBL353212	127144	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	2	1	2	2.5	C1=NC[C@H](C[C@]23CCc4ccccc4C2C3)N1	10.1021/jm001040g
		75306277	116031	0	None	-31	23	Human	7.2	pKi	=	7.2	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	116031	0	None	-31	23	Human	7.2	pKi	=	7.2	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		155550341	181882	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	458	8	0	6	4.2	CCOP(=O)(OCC)C1(Cc2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4568994	181882	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	458	8	0	6	4.2	CCOP(=O)(OCC)C1(Cc2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		1042	8362	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	8362	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	8362	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	8362	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	8362	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		16090635	89290	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	4	1	4	4.7	CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2	10.1021/jm060262x
		CHEMBL217768	89290	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	4	1	4	4.7	CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2	10.1021/jm060262x
		10508332	112768	0	None	-426	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	638	11	2	8	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1	10.1021/jm980077m
		CHEMBL313160	112768	0	None	-426	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	638	11	2	8	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1	10.1021/jm980077m
		10626982	118272	0	None	-11	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	575	9	2	6	5.9	CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL327775	118272	0	None	-11	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	575	9	2	6	5.9	CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		1534	109817	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	109817	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	109817	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		155536080	178893	0	None	-43	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4472703	178893	0	None	-43	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		57394789	78026	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956904	78026	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		1534	109817	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	109817	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	109817	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		162677211	190339	0	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	516	9	5	13	-0.0	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4800292	190339	0	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	516	9	5	13	-0.0	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		487	10406	21	None	-1513	12	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		60602	10406	21	None	-1513	12	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		CHEMBL405355	10406	21	None	-1513	12	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		DB09239	10406	21	None	-1513	12	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		10793963	106448	0	None	-69	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	11	2	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL284470	106448	0	None	-69	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	11	2	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		71652196	94229	0	None	-190	6	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	368	4	1	5	3.6	Oc1ccc(N2CCN(Cc3cnn(-c4ccc(Cl)cc4)c3)CC2)cc1	10.1016/j.ejmech.2012.08.011
		CHEMBL2333732	94229	0	None	-190	6	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	368	4	1	5	3.6	Oc1ccc(N2CCN(Cc3cnn(-c4ccc(Cl)cc4)c3)CC2)cc1	10.1016/j.ejmech.2012.08.011
		3652	53018	70	None	-1	9	Human	5.2	pKi	=	5.2	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		CHEMBL1535	53018	70	None	-1	9	Human	5.2	pKi	=	5.2	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		118717249	121903	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
		CHEMBL3343700	121903	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
		11741010	90026	0	None	-4	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL218730	90026	0	None	-4	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		164609539	191178	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	428	2	0	5	3.3	O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4845850	191178	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	428	2	0	5	3.3	O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		123920	106930	41	None	-309	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1016/j.bmcl.2004.12.013
		CHEMBL287837	106930	41	None	-309	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1016/j.bmcl.2004.12.013
		71459553	90471	10	None	-3	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
		CHEMBL2205360	90471	10	None	-3	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
		1960	9632	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		439260	9632	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		505	9632	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		CHEMBL1437	9632	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		DB00368	9632	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		44325044	214162	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL93801	214162	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44401164	76591	0	None	-346	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	76591	0	None	-346	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		44579271	193873	0	None	-32	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		CHEMBL491419	193873	0	None	-32	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		14004035	126297	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		CHEMBL345621	126297	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		14004035	126297	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		CHEMBL345621	126297	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		24906160	176235	0	None	1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	247	5	1	5	1.4	CO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		CHEMBL442815	176235	0	None	1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	247	5	1	5	1.4	CO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		441082	7946	48	None	-141	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	10.1021/jm8003625
		8981	7946	48	None	-141	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	10.1021/jm8003625
		CHEMBL191703	7946	48	None	-141	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	10.1021/jm8003625
		122442272	145126	0	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	145126	0	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	145126	0	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		240	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		2769	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		44279790	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		660	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL1729	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL560739	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		DB00604	7731	43	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		196129	74573	17	None	-85	15	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	74573	17	None	-85	15	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		26757	214757	31	None	-1	2	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		CHEMBL972	214757	31	None	-1	2	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		10818003	113198	0	None	-12	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	649	12	3	6	6.2	CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1	10.1021/jm980077m
		CHEMBL313953	113198	0	None	-12	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	649	12	3	6	6.2	CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1	10.1021/jm980077m
		10603951	213295	0	None	-33	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	10	1	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL88448	213295	0	None	-33	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	10	1	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		90644753	119545	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	231	3	3	1	2.9	CCCNC(=N)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289537	119545	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	231	3	3	1	2.9	CCCNC(=N)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305462	119545	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	231	3	3	1	2.9	CCCNC(=N)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		3073596	51021	28	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	184	1	1	2	2.8	c1ccc2oc(-c3ncc[nH]3)cc2c1	10.1021/acs.jmedchem.9b02080
		CHEMBL151697	51021	28	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	184	1	1	2	2.8	c1ccc2oc(-c3ncc[nH]3)cc2c1	10.1021/acs.jmedchem.9b02080
		9816063	109851	0	None	-4	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		CHEMBL30739	109851	0	None	-4	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		9816063	109851	0	None	4	6	Rat	7.2	pKi	=	7.2	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		CHEMBL30739	109851	0	None	4	6	Rat	7.2	pKi	=	7.2	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		16090625	89205	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2cccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL217452	89205	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2cccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		130442480	182049	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	182049	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		155556618	181256	0	None	-6456	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL4554295	181256	0	None	-6456	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		4011	89183	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	89183	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		28417	46813	49	None	-1	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	46813	49	None	-1	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		26987	7736	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	7736	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	7736	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	7736	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	7736	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		16215415	194111	1	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		CHEMBL493091	194111	1	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		44330621	11174	0	None	-6	2	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	483	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(Cl)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL101411	11174	0	None	-6	2	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	483	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(Cl)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		90644738	119510	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	281	2	2	2	3.1	c1coc(C2CN/C(=N/c3ccc4c(c3)CCCC4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289548	119510	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	281	2	2	2	3.1	c1coc(C2CN/C(=N/c3ccc4c(c3)CCCC4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304843	119510	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	281	2	2	2	3.1	c1coc(C2CN/C(=N/c3ccc4c(c3)CCCC4)N2)c1	10.1016/j.ejmech.2014.05.057
		155526672	177988	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	528	7	0	6	6.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3c(Cl)cc(Cl)cc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4459403	177988	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	528	7	0	6	6.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3c(Cl)cc(Cl)cc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		155535203	178820	0	None	-18	6	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		CHEMBL4471712	178820	0	None	-18	6	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		10198108	214984	2	None	7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	200	0	1	2	1.9	Cc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL98471	214984	2	None	7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	200	0	1	2	1.9	Cc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		12575	8769	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm800250z
		54459	8769	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm800250z
		CHEMBL10316	8769	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm800250z
		12575	8769	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmc.2012.02.016
		54459	8769	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmc.2012.02.016
		CHEMBL10316	8769	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmc.2012.02.016
		12774559	196388	0	None	-	1	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		CHEMBL51479	196388	0	None	-	1	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		185076	193869	5	None	2	7	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL49137	193869	5	None	2	7	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		213041	23905	28	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	230	2	1	1	3.0	CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1	10.1021/jm1006269
		CHEMBL1255582	23905	28	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	230	2	1	1	3.0	CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1	10.1021/jm1006269
		102	10899	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		3659	10899	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		8969	10899	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		CHEMBL15245	10899	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		DB01392	10899	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		155513073	176494	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	440	8	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(Cc3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4438158	176494	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	440	8	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(Cc3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		11412944	108286	69	None	223	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL298004	108286	69	None	223	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccnc1N1CCNCC1	10.1021/jm00366a007
		135545454	85718	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	448	7	1	7	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112983	85718	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	448	7	1	7	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		2803	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		516	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		704	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		CHEMBL134	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		DB00575	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		13123533	201688	1	None	-	1	Bovine	7.2	pKi	=	7.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		CHEMBL541208	201688	1	None	-	1	Bovine	7.2	pKi	=	7.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		155544935	180196	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	460	7	0	6	4.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4528557	180196	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	460	7	0	6	4.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		162654541	187392	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	499	10	5	11	0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4754656	187392	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	499	10	5	11	0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		10045713	172884	0	None	-309	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	386	3	1	4	5.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C	10.1021/jm060262x
		CHEMBL425983	172884	0	None	-309	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	386	3	1	4	5.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C	10.1021/jm060262x
		122186880	129758	0	None	-7	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to alpha2A adrenoceptor (unknown origin)Binding affinity to alpha2A adrenoceptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3608450	129758	0	None	-7	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to alpha2A adrenoceptor (unknown origin)Binding affinity to alpha2A adrenoceptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		44401106	131105	0	None	-112	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL363581	131105	0	None	-112	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		57345627	77957	0	None	8	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	230	4	1	3	2.5	C=C(C)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956194	77957	0	None	8	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	230	4	1	3	2.5	C=C(C)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		44269089	103780	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	3	2.6	CC(Oc1ccccc1C(C)C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL266613	103780	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	3	2.6	CC(Oc1ccccc1C(C)C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		16757182	160030	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL397753	160030	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		16757182	160030	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL397753	160030	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		11183468	116649	2	None	-1	6	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	213	1	2	2	2.5	Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL323402	116649	2	None	-1	6	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	213	1	2	2	2.5	Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		4567175	89251	5	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	318	3	1	4	3.7	CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1	10.1021/jm060262x
		CHEMBL217665	89251	5	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	318	3	1	4	3.7	CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1	10.1021/jm060262x
		24906201	194132	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		CHEMBL493272	194132	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		1016	10519	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		3157	8252	71	None	-61	12	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		7170	8252	71	None	-61	12	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		954	8252	71	None	-61	12	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		CHEMBL707	8252	71	None	-61	12	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		DB00590	8252	71	None	-61	12	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		56964693	80837	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	314	0	1	5	2.8	Clc1ccc2c(c1)N=C(N1CCNCC1)c1cccnc1O2	10.1021/jm2013419
		CHEMBL2022269	80837	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	314	0	1	5	2.8	Clc1ccc2c(c1)N=C(N1CCNCC1)c1cccnc1O2	10.1021/jm2013419
		12841596	124238	20	None	3	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligandBinding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligand	ChEMBL	237	1	1	5	0.8	Clc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL2448004	124238	20	None	3	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligandBinding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligand	ChEMBL	237	1	1	5	0.8	Clc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL339883	124238	20	None	3	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligandBinding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligand	ChEMBL	237	1	1	5	0.8	Clc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		12909383	137481	1	None	-5	2	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	278	0	0	2	3.6	CN1CCC(=C2c3ccccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368413	137481	1	None	-5	2	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	278	0	0	2	3.6	CN1CCC(=C2c3ccccc3CCn3cccc32)CC1	10.1021/jm00361a008
		44292470	108412	5	None	57	2	Bovine	7.1	pKi	=	7.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	1	3	1.5	Cc1ccnc(N2CCNCC2)c1Cl	10.1021/jm00366a007
		CHEMBL299007	108412	5	None	57	2	Bovine	7.1	pKi	=	7.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	1	3	1.5	Cc1ccnc(N2CCNCC2)c1Cl	10.1021/jm00366a007
		136044137	85712	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	472	6	1	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112976	85712	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	472	6	1	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CN2	10.1021/jm049619s
		25130235	194366	1	None	-2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	194366	1	None	-2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		15675860	211208	0	None	4	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		CHEMBL72147	211208	0	None	4	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		23622576	179551	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
		CHEMBL451229	179551	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
		3823	56995	42	None	-40	11	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	56995	42	None	-40	11	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	56995	42	None	-40	11	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		1577	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		2537	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5355	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5501	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		643497	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		688272	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		958	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		960	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL196677	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL26	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL267044	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB00391	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB16021	10475	110	None	-3	20	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		10674896	213423	0	None	-416	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	588	9	2	6	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1	10.1021/jm980077m
		CHEMBL89243	213423	0	None	-416	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	588	9	2	6	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1	10.1021/jm980077m
		657255	205863	34	None	-10	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	205863	34	None	-10	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		155567867	182812	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	502	8	0	6	5.7	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4590209	182812	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	502	8	0	6	5.7	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		10454026	24679	0	None	-234	8	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		CHEMBL125916	24679	0	None	-234	8	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		10895039	25292	0	None	-51	7	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL127400	25292	0	None	-51	7	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL129022	25292	0	None	-51	7	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		10655607	211534	5	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	199	2	3	3	2.0	c1c[nH]c(Nc2ccc3[nH]cnc3c2)n1	10.1021/jm9605142
		CHEMBL74544	211534	5	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	199	2	3	3	2.0	c1c[nH]c(Nc2ccc3[nH]cnc3c2)n1	10.1021/jm9605142
		10326069	46070	1	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL147077	46070	1	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		53324553	63629	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		CHEMBL1643900	63629	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		53324553	63629	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL1643900	63629	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		1210	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	7705	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		72947314	99265	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.0	c1ccc(OCC2=NCCN2)c(CC2CC2)c1	10.1021/ml400232p
		CHEMBL2431281	99265	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.0	c1ccc(OCC2=NCCN2)c(CC2CC2)c1	10.1021/ml400232p
		490	6979	8	None	-758	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		9890547	6979	8	None	-758	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		CHEMBL268758	6979	8	None	-758	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		12909389	67143	0	None	-64	2	Bovine	4.1	pKi	=	4.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	320	1	1	3	3.7	CN1CCC(=C2c3cc(C(=O)O)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL174649	67143	0	None	-64	2	Bovine	4.1	pKi	=	4.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	320	1	1	3	3.7	CN1CCC(=C2c3cc(C(=O)O)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		16090598	89230	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL217568	89230	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		5467	212707	43	None	-6	5	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		CHEMBL84158	212707	43	None	-6	5	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		44288847	172088	0	None	-5495	5	Human	5.1	pKi	=	5.1	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	535	7	2	5	3.9	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL42335	172088	0	None	-5495	5	Human	5.1	pKi	=	5.1	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	535	7	2	5	3.9	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		5897	111988	80	None	-7	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		CHEMBL311469	111988	80	None	-7	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		44401164	76591	0	None	-346	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	76591	0	None	-346	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		90644744	119518	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	205	3	2	2	1.3	CCOc1ccc(N=C2NCCN2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289551	119518	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	205	3	2	2	1.3	CCOc1ccc(N=C2NCCN2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304991	119518	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	205	3	2	2	1.3	CCOc1ccc(N=C2NCCN2)cc1	10.1016/j.ejmech.2014.05.057
		16090623	89229	0	None	-102	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		CHEMBL217567	89229	0	None	-102	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		44415690	86912	0	None	-363	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213336	86912	0	None	-363	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		10923927	210957	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	279	3	2	5	0.8	O=S1(=O)CCCc2cccc(NCC3=NCCN3)c21	10.1021/jm000542r
		CHEMBL70740	210957	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	279	3	2	5	0.8	O=S1(=O)CCCc2cccc(NCC3=NCCN3)c21	10.1021/jm000542r
		6604789	107824	5	None	-31	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL294649	107824	5	None	-31	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		57399991	78023	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2CO[C@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956901	78023	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2CO[C@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		12575	8769	30	None	-5	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmcl.2006.12.094
		54459	8769	30	None	-5	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmcl.2006.12.094
		CHEMBL10316	8769	30	None	-5	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmcl.2006.12.094
		134987	193460	47	None	309	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	181	1	1	3	0.6	Fc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL48833	193460	47	None	309	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	181	1	1	3	0.6	Fc1cccnc1N1CCNCC1	10.1021/jm00366a007
		441975	23223	56	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL123325	23223	56	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		49864359	22398	0	None	3	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	467	10	1	5	4.1	COc1ccccc1N1CCN(CCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221592	22398	0	None	3	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	467	10	1	5	4.1	COc1ccccc1N1CCN(CCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		124	9755	47	None	-4	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2032	9755	47	None	-4	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		4636	9755	47	None	-4	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL762	9755	47	None	-4	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		DB00935	9755	47	None	-4	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2803	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		516	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		704	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		CHEMBL134	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		DB00575	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		10775000	114171	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	214	1	2	2	2.6	Oc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL317912	114171	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	214	1	2	2	2.6	Oc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		44324765	118345	0	None	-2	5	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL328114	118345	0	None	-2	5	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		9846548	214104	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL93489	214104	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		1212	8443	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		9960497	107252	0	None	-2454	6	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		CHEMBL290860	107252	0	None	-2454	6	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		16090628	148565	0	None	-933	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	4	1	4	5.3	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(N2CCCN(C)CC2)cc1	10.1021/jm060262x
		CHEMBL386169	148565	0	None	-933	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	4	1	4	5.3	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(N2CCCN(C)CC2)cc1	10.1021/jm060262x
		44574075	179355	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL448802	179355	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		4601	213526	35	None	-2	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	213526	35	None	-2	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	213526	35	None	-2	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		10466448	119660	2	None	34	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	0	5	0.8	Cc1cnc(N2CCN(C)CC2)c2nccn12	10.1021/jm00099a012
		CHEMBL330994	119660	2	None	34	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	0	5	0.8	Cc1cnc(N2CCN(C)CC2)c2nccn12	10.1021/jm00099a012
		44579229	196395	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		CHEMBL514837	196395	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		11000184	19824	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL1190038	19824	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL540035	19824	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		10859076	20454	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL1194763	20454	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL553276	20454	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		127036932	144126	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752900	144126	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		16757089	99066	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL242693	99066	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		16757089	99066	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL242693	99066	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		11448533	91466	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	0	3	3.6	CC(Oc1ccccc1-c1ccccc1)C1=NCCO1	10.1021/jm0408215
		CHEMBL222591	91466	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	0	3	3.6	CC(Oc1ccccc1-c1ccccc1)C1=NCCO1	10.1021/jm0408215
		11473729	91467	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	0	2	4.4	CC(Oc1ccccc1-c1ccccc1)C1=NCCC1	10.1021/jm0408215
		CHEMBL222593	91467	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	0	2	4.4	CC(Oc1ccccc1-c1ccccc1)C1=NCCC1	10.1021/jm0408215
		136680386	214482	0	None	-169	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	680	16	4	8	4.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1	10.1016/s0960-894x(99)00484-9
		44328801	214482	0	None	-169	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	680	16	4	8	4.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL95578	214482	0	None	-169	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	680	16	4	8	4.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1	10.1016/s0960-894x(99)00484-9
		491	6980	9	None	-1023	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		9891167	6980	9	None	-1023	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		CHEMBL13856	6980	9	None	-1023	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		1530	8963	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3038495	7495	37	None	-56	18	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		7625	7495	37	None	-56	18	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		CHEMBL25236	7495	37	None	-56	18	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		57345629	77960	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1956197	77960	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1021/ml400232p
		127036953	144293	0	None	-8	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754166	144293	0	None	-8	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		44269140	40327	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	248	5	1	4	2.2	CC(C)Oc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL14208	40327	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	248	5	1	4	2.2	CC(C)Oc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		57345629	77960	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956197	77960	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		9817231	165015	22	None	1	7	Human	5.1	pKi	=	5.1	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		CHEMBL4088272	165015	22	None	1	7	Human	5.1	pKi	=	5.1	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		90644755	119505	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	5	4	2	2.5	CCCNC(=N)Nc1ccc(NCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289538	119505	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	5	4	2	2.5	CCCNC(=N)Nc1ccc(NCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304668	119505	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	5	4	2	2.5	CCCNC(=N)Nc1ccc(NCC)cc1	10.1016/j.ejmech.2014.05.057
		10044968	103320	0	None	-54	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL262901	103320	0	None	-54	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		56852956	118820	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	118820	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL4642079	220802	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		Cc1c(N2CCNCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl	10.6019/CHEMBL4630901
		9904606	16158	0	None	2	4	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	3	1	3	2.3	CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O	10.1021/jm030551a
		CHEMBL111463	16158	0	None	2	4	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	3	1	3	2.3	CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O	10.1021/jm030551a
		16090594	88900	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		CHEMBL216674	88900	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		56852956	118820	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	118820	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL4642079	220802	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		Cc1c(N2CCNCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl	10.6019/CHEMBL4630901
		2803	7742	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		516	7742	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		704	7742	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		CHEMBL134	7742	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		DB00575	7742	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		2803	7742	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		516	7742	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		704	7742	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		CHEMBL134	7742	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		DB00575	7742	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		237	211644	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	211644	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	211644	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	211644	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		11293787	154992	0	None	-77	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL393597	154992	0	None	-77	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		155552185	180840	0	None	-1548	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4544086	180840	0	None	-1548	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		44582676	196558	0	None	-6	17	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned alpha2A adrenergic receptor by competitive binding experimentInhibition of human cloned alpha2A adrenergic receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	196558	0	None	-6	17	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned alpha2A adrenergic receptor by competitive binding experimentInhibition of human cloned alpha2A adrenergic receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		10398419	123419	0	None	13	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CCC1(CN=CN1)C2	10.1021/jm00020a021
		CHEMBL336970	123419	0	None	13	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CCC1(CN=CN1)C2	10.1021/jm00020a021
		136019934	151308	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		CHEMBL390718	151308	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		44350063	124726	0	None	-	1	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	349	4	3	7	-0.0	C1=CN2CCN=C2C(N2CCNCC2)=N1.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		CHEMBL340358	124726	0	None	-	1	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	349	4	3	7	-0.0	C1=CN2CCN=C2C(N2CCNCC2)=N1.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		11058166	211484	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL74114	211484	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1	10.1021/jm000542r
		9931977	69814	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		CHEMBL1788223	69814	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		132060763	169640	0	None	-3	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	5	0	4	4.1	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4173095	169640	0	None	-3	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	5	0	4	4.1	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		44415593	87022	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213834	87022	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11732785	170499	0	None	-18	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		CHEMBL420510	170499	0	None	-18	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		10473701	90013	0	None	-165	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	3	1	4	4.8	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)(C)C2)cc1	10.1021/jm060262x
		CHEMBL218679	90013	0	None	-165	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	3	1	4	4.8	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)(C)C2)cc1	10.1021/jm060262x
		44424855	92229	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL226636	92229	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		44330609	170231	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL419894	170231	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		135405894	85705	0	None	-5	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	470	8	1	8	2.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(CCOc4ccc(F)cc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112969	85705	0	None	-5	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	470	8	1	8	2.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(CCOc4ccc(F)cc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		10028898	118432	0	None	-11	2	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL328631	118432	0	None	-11	2	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		123981	23231	22	None	-2	8	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	10.1021/jm00019a001
		CHEMBL123349	23231	22	None	-2	8	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	10.1021/jm00019a001
		CHEMBL536803	23231	22	None	-2	8	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	10.1021/jm00019a001
		9816048	194057	0	None	12	3	Human	8.0	pKi	=	8.0	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	231	1	4	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCN2	10.1021/jm960359r
		CHEMBL49284	194057	0	None	12	3	Human	8.0	pKi	=	8.0	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	231	1	4	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCN2	10.1021/jm960359r
		463	8187	22	None	-67	13	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		6918097	8187	22	None	-67	13	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		837	8187	22	None	-67	13	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		CHEMBL2051956	8187	22	None	-67	13	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		DB14068	8187	22	None	-67	13	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		16090627	88342	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	9	2	4	5.9	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(NCCN(CC)CC)cc1	10.1021/jm060262x
		CHEMBL216197	88342	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	9	2	4	5.9	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(NCCN(CC)CC)cc1	10.1021/jm060262x
		2683	109665	25	None	-12	16	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	109665	25	None	-12	16	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	109665	25	None	-12	16	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		10333157	158017	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL396013	158017	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		11140033	27455	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL130884	27455	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		10333157	158017	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL396013	158017	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		16090595	148179	0	None	-109	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL383978	148179	0	None	-109	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		10651654	118260	0	None	-489	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	631	9	2	5	7.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1	10.1021/jm980077m
		CHEMBL327712	118260	0	None	-489	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	631	9	2	5	7.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1	10.1021/jm980077m
		10084076	104692	0	None	-5	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
		CHEMBL27251	104692	0	None	-5	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
		44324737	214017	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL92860	214017	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44568614	194402	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	252	4	1	3	2.8	c1ccc(OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		CHEMBL494885	194402	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	252	4	1	3	2.8	c1ccc(OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		2337	10030	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	10030	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	10030	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	10030	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	10030	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5280805	92180	81	None	-28	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	10.1021/np1000329
		CHEMBL226335	92180	81	None	-28	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	10.1021/np1000329
		25110718	200088	0	None	-72	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		CHEMBL524153	200088	0	None	-72	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		10527469	163044	3	None	-204	16	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		CHEMBL40650	163044	3	None	-204	16	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		164609730	191878	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	398	2	1	5	3.5	CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4856060	191878	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	398	2	1	5	3.5	CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		71463022	90473	7	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	436	8	0	5	5.3	COc1cc2oc(C(=O)N(CCCN3CCCCC3)c3ccccc3)c(C)c2cc1OC	10.1016/j.bmc.2012.09.044
		CHEMBL2205362	90473	7	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	436	8	0	5	5.3	COc1cc2oc(C(=O)N(CCCN3CCCCC3)c3ccccc3)c(C)c2cc1OC	10.1016/j.bmc.2012.09.044
		24841480	190678	0	None	-47	20	Human	7.0	pKi	=	7.0	Binding	Antagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	190678	0	None	-47	20	Human	7.0	pKi	=	7.0	Binding	Antagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		10489502	11290	2	None	6	3	Human	7.0	pKi	=	7.0	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	2	2	2	3.5	Clc1cccc(Cl)c1Nc1ncc[nH]1	10.1021/jm9605142
		CHEMBL1022	11290	2	None	6	3	Human	7.0	pKi	=	7.0	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	2	2	2	3.5	Clc1cccc(Cl)c1Nc1ncc[nH]1	10.1021/jm9605142
		28918670	99262	2	None	4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	254	3	1	3	1.8	Brc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		CHEMBL2431279	99262	2	None	4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	254	3	1	3	1.8	Brc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		10508132	113794	0	None	-16	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	10	2	6	5.5	CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1	10.1021/jm980077m
		CHEMBL315392	113794	0	None	-16	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	10	2	6	5.5	CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1	10.1021/jm980077m
		10507651	213286	0	None	-107	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	591	9	2	6	5.8	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		CHEMBL88388	213286	0	None	-107	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	591	9	2	6	5.8	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		9950711	115983	0	None	-5	4	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	359	4	2	3	3.2	O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL321644	115983	0	None	-5	4	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	359	4	2	3	3.2	O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		14004033	56006	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL156283	56006	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		78114671	180943	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	350	6	0	6	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4546903	180943	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	350	6	0	6	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		44328654	113962	0	None	-251	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	663	14	3	6	6.7	CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL316495	113962	0	None	-251	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	663	14	3	6	6.7	CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1	10.1016/s0960-894x(99)00484-9
		21830793	98610	10	None	-630	46	Human	7.0	pKi	=	7.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		CHEMBL2413154	98610	10	None	-630	46	Human	7.0	pKi	=	7.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		139406787	183924	0	None	2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	492	5	2	5	5.8	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1	10.1021/acs.jmedchem.0c00745
		CHEMBL4633982	183924	0	None	2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	492	5	2	5	5.8	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1	10.1021/acs.jmedchem.0c00745
		10251036	88660	0	None	-162	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	410	4	2	5	4.7	CN1CCN(c2ccc(Nc3c(CO)cnc4cc(Cl)ccc34)cc2)CC1(C)C	10.1021/jm060262x
		CHEMBL216464	88660	0	None	-162	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	410	4	2	5	4.7	CN1CCN(c2ccc(Nc3c(CO)cnc4cc(Cl)ccc34)cc2)CC1(C)C	10.1021/jm060262x
		14004033	56006	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL156283	56006	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		16090632	148494	0	None	-46	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	348	4	3	5	3.3	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1	10.1021/jm060262x
		CHEMBL385722	148494	0	None	-46	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	348	4	3	5	3.3	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1	10.1021/jm060262x
		2777786	181756	82	None	29	2	Bovine	7.0	pKi	=	7.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.5	FC(F)(F)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL45663	181756	82	None	29	2	Bovine	7.0	pKi	=	7.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.5	FC(F)(F)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		57399145	77959	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	234	5	1	4	1.9	CCOc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956196	77959	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	234	5	1	4	1.9	CCOc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		49836307	25557	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1278085	25557	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		9879119	16218	0	None	-4	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	4	2	3	2.2	CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL111771	16218	0	None	-4	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	4	2	3	2.2	CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1	10.1021/jm030551a
		11747739	20007	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL1191324	20007	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL542402	20007	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		44324860	214277	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cc5ccccc5s4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL94435	214277	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cc5ccccc5s4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		16090633	87236	0	None	-25	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		CHEMBL214661	87236	0	None	-25	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		4209	9937	75	None	-1380	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		4893	9937	75	None	-1380	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		503	9937	75	None	-1380	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		5385	9937	75	None	-1380	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL2	9937	75	None	-1380	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		DB00457	9937	75	None	-1380	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		44329026	215204	0	None	-19	6	Human	7.0	pKi	=	7	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	679	16	3	7	6.1	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL99864	215204	0	None	-19	6	Human	7.0	pKi	=	7	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	679	16	3	7	6.1	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1	10.1016/s0960-894x(99)00484-9
		2105	9828	37	None	-13	32	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	9828	37	None	-13	32	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	9828	37	None	-13	32	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	9828	37	None	-13	32	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	9828	37	None	-13	32	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		44574078	185540	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL468711	185540	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		168274641	197214	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2ccc(O)cc2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		CHEMBL5178192	197214	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2ccc(O)cc2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		2477	7532	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	7532	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	7532	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	7532	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	7532	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		3689	109548	55	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandCompound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		CHEMBL1372983	109548	55	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandCompound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		CHEMBL305187	109548	55	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandCompound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		2803	7742	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		3294	8787	111	None	-	44	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	None	-	44	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	None	-	44	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	None	-	44	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	None	-	44	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1795	8372	64	None	-	1	Human	1.8	pKd	=	1.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	299	4	3	5	0.4	CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C	1325028
		4186	8372	64	None	-	1	Human	1.8	pKd	=	1.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	299	4	3	5	0.4	CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C	1325028
		CHEMBL517986	8372	64	None	-	1	Human	1.8	pKd	=	1.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	299	4	3	5	0.4	CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C	1325028
		1192	6935	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	1325028
		1192	6935	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	9584219
		1794	6935	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	1325028
		1794	6935	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	9584219
		CHEMBL501701	6935	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	1325028
		CHEMBL501701	6935	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	9584219
		108094	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		108094	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		108094	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		526	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		526	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		526	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		528	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		528	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		528	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		CHEMBL10332	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		CHEMBL10332	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		CHEMBL10332	10196	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		136	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		136	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		136	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		223	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		223	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		223	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		643606	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		643606	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		643606	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		CHEMBL10347	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		CHEMBL10347	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		CHEMBL10347	10065	32	None	-3	16	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		2435	7509	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		395	7509	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		520	7509	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		5386	7509	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		CHEMBL844	7509	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		DB00484	7509	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		1588	9105	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL1196898	222809	0	3H-RAUWOLSCINE	1	3	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	248	3	1	5	1.2	CCOC1(COC2=CC=CC=C2O1)C3=NCCN3	None
		2601	10552	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		138107169	222731	0	3H-RAUWOLSCINE	-6	23	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-RAUWOLSCINE	-6	23	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		12576	7302	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		71310	7302	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		CHEMBL353972	7302	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		DB11481	7302	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		108094	10196	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	10196	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	10196	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	10196	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		None	222808	0	3H-RAUWOLSCINE	-2	3	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	953	28	10	12	0.9	CCOC1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C=S)C(=O)NC(CCCCN)C(=O)N)NC(=O)CC3(CCCCC3)S	None
		138107169	222731	0	3H-RX821002	1	23	Pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-RX821002	1	23	Pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	222807	0	3H-RAUWOLSCINE	-13	3	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	339	0	0	3	3.3	CN1CCC2(CCN3CCC4=C(C3C2)OC5=CC=CC=C45)N(C1=O)C	None
		138107169	222731	0	3H-RAUWOLSCINE	-6	23	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-RAUWOLSCINE	-6	23	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		102	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		108094	10196	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		108094	10196	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	10196	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	10196	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	10196	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	10196	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	10196	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	10196	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		102	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		164512323	222810	0	3H-RAUWOLSCINE	-5	5	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RAUWOLSCINE	-5	5	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		124	9755	47	3H-RAUWOLSCINE	-4	32	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-RAUWOLSCINE	-4	32	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-RAUWOLSCINE	-4	32	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-RAUWOLSCINE	-4	32	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-RAUWOLSCINE	-4	32	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		None	222737	0	3H-RAUWOLSCINE	-14	19	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		108094	10196	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	10196	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	10196	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	10196	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		None	222740	0	3H-RAUWOLSCINE	-1	5	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	295	5	2	3	3.0	C1CC2=CC=CC=C2C(=O)C1CNCCC3=CC=C(C=C3)O	None
		None	222737	0	3H-RX821002	-6	19	Pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		108094	10196	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	10196	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	10196	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	10196	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		138107169	222731	0	35S-GTPGammaS	-6	23	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	35S-GTPGammaS	-6	23	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	222737	0	3H-RAUWOLSCINE	-14	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		41	8440	0	3H-PRAZOSIN	-1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	8440	0	3H-PRAZOSIN	-1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	8440	0	3H-PRAZOSIN	-1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		None	222737	0	3H-RAUWOLSCINE	-14	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		124	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	9755	47	3H-CLONIDINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-CLONIDINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-CLONIDINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-CLONIDINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-CLONIDINE	-4	32	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2142	9870	58	3H-RX821002	-2	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RX821002	-2	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RX821002	-2	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RX821002	-2	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RX821002	-2	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RX821002	-2	37	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		102	10899	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	223486	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	390	1	2	4	3.1	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl	None
		12575	8769	30	3H-RAUWOLSCINE	-5	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	8769	30	3H-RAUWOLSCINE	-5	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	8769	30	3H-RAUWOLSCINE	-5	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		2389	10104	118	3H-RAUWOLSCINE	-77	66	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-RAUWOLSCINE	-77	66	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-RAUWOLSCINE	-77	66	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-RAUWOLSCINE	-77	66	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-RAUWOLSCINE	-77	66	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		164512323	222810	0	3H-RX821002	-18	5	Pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RX821002	-18	5	Pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		46780481	114308	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		521	8186	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		5311068	8186	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		835	8186	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		CHEMBL778	8186	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		DB00633	8186	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		31101	7516	40	3H-RX821002	-10	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	3H-RX821002	-10	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	3H-RX821002	-10	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	3H-RX821002	-10	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	3H-RX821002	-10	35	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		202	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		104870	105656	47	3H-Yohimbine	-54	21	Pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	105656	47	3H-Yohimbine	-54	21	Pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	105656	47	3H-Yohimbine	-54	21	Pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5656	209845	87	UNDEFINED	-25	43	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	UNDEFINED	-25	43	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	209906	52	UNDEFINED	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	209906	52	UNDEFINED	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		165193	222724	0	3H-RAUWOLSCINE	-4265	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-RAUWOLSCINE	-4265	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-RAUWOLSCINE	-4265	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		3075702	224111	0	3H-RAUWOLSCINE	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		1499	8872	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		1499	8872	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		3779	8872	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		3779	8872	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		536	8872	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		536	8872	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		CHEMBL434	8872	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		CHEMBL434	8872	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		DB01064	8872	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		DB01064	8872	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		243	9976	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	9976	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	9976	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	9976	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	9976	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		2	10035	23	3H-RX821002	-2089	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	10035	23	3H-RX821002	-2089	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	10035	23	3H-RX821002	-2089	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		183782	10171	20	3H-RAUWOLSCINE	-2398	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		237	10171	20	3H-RAUWOLSCINE	-2398	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL85251	10171	20	3H-RAUWOLSCINE	-2398	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		6917970	10463	61	3H-CLONIDINE	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	10463	61	3H-CLONIDINE	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	10463	61	3H-CLONIDINE	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		2662	18156	131	3H-CLONIDINE	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	18156	131	3H-CLONIDINE	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		5090	22333	106	3H-CLONIDINE	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	22333	106	3H-CLONIDINE	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		127151	42104	18	3H-RX821002	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		3022645	42104	18	3H-RX821002	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		CHEMBL14370	42104	18	3H-RX821002	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		156391	53574	99	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	53574	99	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	53574	99	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		10624	77075	19	125I-Clonidine	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	77075	19	125I-Clonidine	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	77075	19	125I-Clonidine	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		2244	101008	100	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	101008	100	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		3663	106743	83	3H-CLONIDINE	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	106743	83	3H-CLONIDINE	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		446220	140299	14	3H-CLONIDINE	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	140299	14	3H-CLONIDINE	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		5280343	195054	124	3H-CLONIDINE	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	195054	124	3H-CLONIDINE	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	195054	124	3H-CLONIDINE	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		3672	199312	136	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	199312	136	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	200394	112	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	200394	112	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		2771	201796	74	3H-RAUWOLSCINE	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	201796	74	3H-RX821002	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	201796	74	3H-RAUWOLSCINE	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	201796	74	3H-RX821002	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	201796	74	3H-RAUWOLSCINE	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	201796	74	3H-RX821002	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		4495	203314	92	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	203314	92	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	207330	115	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	207330	115	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	207330	115	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		5281600	209804	92	3H-CLONIDINE	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	209804	92	3H-CLONIDINE	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	209845	87	3H-RX821002	-25	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	3H-RX821002	-25	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		4054	212280	72	125I-Clonidine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	212280	72	125I-Clonidine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	212280	72	125I-Clonidine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		119607	212982	113	3H-CLONIDINE	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	212982	113	3H-CLONIDINE	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		None	222772	0	3H-RAUWOLSCINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	222798	0	3H-CLONIDINE	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	222806	0	3H-RAUWOLSCINE	-6309	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
		25137849	222958	0	3H-CLONIDINE	-2	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	222958	0	3H-CLONIDINE	-2	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		31404	222972	0	3H-Yohimbine	-	1	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	253	1	1	4	1.5	CCN1CCC2=C(CC1)OC(=N2)N.Cl.Cl	None
		None	223090	0	3H-CLONIDINE	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	223091	0	3H-CLONIDINE	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	223092	0	3H-CLONIDINE	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	223093	0	3H-CLONIDINE	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	223094	0	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	223095	0	3H-CLONIDINE	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	223096	0	3H-CLONIDINE	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	223097	0	3H-CLONIDINE	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	223106	0	3H-CLONIDINE	-16	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	223107	0	3H-CLONIDINE	-7	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	223108	0	3H-CLONIDINE	2	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	223110	0	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		None	223121	0	3H-RX821002	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		135269	223168	0	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	223169	0	3H-CLONIDINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	223170	0	3H-CLONIDINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	223171	0	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	223172	0	3H-CLONIDINE	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	223173	0	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	223174	0	3H-CLONIDINE	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	223268	0	3H-CLONIDINE	-4570	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		11954224	222732	0	3H-CLONIDINE	-446	59	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1830	9368	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	9368	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	9368	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	9368	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	9368	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		None	222811	0	3H-RAUWOLSCINE	-19	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	401	6	1	5	0.6	CS(=O)(=O)NCCN(C1CCN2CCC3=CC=CC=C3C2C1)S(=O)(=O)C	None
		11079	9510	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	9510	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	9510	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	9510	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	9510	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	9510	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		179	7188	115	125I-Clonidine	-35	50	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	125I-Clonidine	-35	50	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	125I-Clonidine	-35	50	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	125I-Clonidine	-35	50	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	125I-Clonidine	-35	50	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		1353	8692	93	3H-CLONIDINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-CLONIDINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-CLONIDINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-CLONIDINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-CLONIDINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		4209	9937	75	3H-RX821002	-794	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	3H-RX821002	-794	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	3H-RX821002	-794	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	3H-RX821002	-794	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	3H-RX821002	-794	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	3H-RX821002	-794	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		None	223120	0	3H-RX821002	-15	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		1267	10576	49	3H-RAUWOLSCINE	-52	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-RAUWOLSCINE	-52	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-RAUWOLSCINE	-52	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		None	223158	0	3H-RAUWOLSCINE	-141	11	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
		5268	10428	40	3H-RAUWOLSCINE	-63	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	10428	40	3H-RAUWOLSCINE	-63	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	10428	40	3H-RAUWOLSCINE	-63	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		68602	211905	80	35S-GTPGammaS	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	211905	80	35S-GTPGammaS	-1	8	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		164512323	222810	0	3H-RAUWOLSCINE	-5	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RAUWOLSCINE	-5	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		122211	7250	0	3H-RAUWOLSCINE	-239	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	7250	0	3H-RAUWOLSCINE	-239	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		138107169	222731	0	3H-RAUWOLSCINE	-6	23	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-RAUWOLSCINE	-6	23	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		122211	7250	0	3H-MK912	-239	6	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	7250	0	3H-MK912	-239	6	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		10297	33885	30	3H-CLONIDINE	-5	43	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	33885	30	3H-CLONIDINE	-5	43	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		100	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		100	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-CLONIDINE	-33	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		44438148	100265	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	None
		CHEMBL246229	100265	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	None
		135409468	8816	69	3H-CLONIDINE	-48	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	8816	69	3H-CLONIDINE	-48	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	8816	69	3H-CLONIDINE	-48	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		2995	211184	53	3H-RAUWOLSCINE	-12	23	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	3H-RAUWOLSCINE	-12	23	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	3H-RAUWOLSCINE	-12	23	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		None	222737	0	3H-MK912	-14	19	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		164512323	222810	0	3H-RX821002	-18	5	Pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RX821002	-18	5	Pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		44438166	100592	0	UNDEFINED	-33	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	None
		CHEMBL247664	100592	0	UNDEFINED	-33	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	None
		25058166	222739	0	3H-RX821002	-70	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-RX821002	-70	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		484	9633	51	35S-GTPGammaS	-14	35	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	35S-GTPGammaS	-14	35	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	35S-GTPGammaS	-14	35	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		135398737	7745	93	3H-CLONIDINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-RAUWOLSCINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-CLONIDINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-RAUWOLSCINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-CLONIDINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-RAUWOLSCINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-CLONIDINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-RAUWOLSCINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-CLONIDINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-RAUWOLSCINE	-26	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		7153	104796	77	3H-CLONIDINE	-7	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-CLONIDINE	-7	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		1028	7079	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		3658	10879	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	10879	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	10879	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	10879	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	10879	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		124	9755	47	35S-GTPGammaS	-28	32	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	35S-GTPGammaS	-28	32	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	35S-GTPGammaS	-28	32	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	35S-GTPGammaS	-28	32	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	35S-GTPGammaS	-28	32	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		5524	223243	0	35S-GTPGammaS	-1	4	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	215	1	2	3	1.9	C1CCC2=C(C1)C=CC=C2NC3=NCCN3	None
		68602	211905	80	3H-MK912	-1	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	211905	80	3H-MK912	-1	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		1613	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2389	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1613	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2389	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-CLONIDINE	-77	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		68712	107114	60	35S-GTPGammaS	-1	5	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		CHEMBL289480	107114	60	35S-GTPGammaS	-1	5	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		186	8588	52	3H-CLONIDINE	-263	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	8588	52	3H-CLONIDINE	-263	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	8588	52	3H-CLONIDINE	-263	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		16362	9899	71	3H-CLONIDINE	-501	29	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-CLONIDINE	-501	29	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-CLONIDINE	-501	29	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-CLONIDINE	-501	29	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-CLONIDINE	-501	29	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		11079	9510	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	9510	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	9510	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	9510	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	9510	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	9510	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		2865	10915	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2865	10915	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3294	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		3294	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-RX821002	-47	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		119570	9933	96	3H-RX821002	-41	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-RX821002	-41	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-RX821002	-41	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-RX821002	-41	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-RX821002	-41	39	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		1223	7740	41	3H-RAUWOLSCINE	-93	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	7740	41	3H-RAUWOLSCINE	-93	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	7740	41	3H-RAUWOLSCINE	-93	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		134	9292	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		122211	7250	0	3H-RAUWOLSCINE	-239	6	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	7250	0	3H-RAUWOLSCINE	-239	6	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		16725934	154201	0	UNDEFINED	-87	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	None
		CHEMBL392992	154201	0	UNDEFINED	-87	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	None
		15897	9637	0	3H-CLONIDINE	-134	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-CLONIDINE	-134	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-CLONIDINE	-134	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		103	10925	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	7706	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1220	6975	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		44438168	100593	0	UNDEFINED	-53	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	None
		CHEMBL247665	100593	0	UNDEFINED	-53	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	None
		2402	10143	62	3H-RX821002	-5	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	10143	62	3H-RX821002	-5	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	10143	62	3H-RX821002	-5	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	10143	62	3H-RX821002	-5	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	10143	62	3H-RX821002	-5	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		2142	9870	58	3H-RX821002	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RX821002	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RX821002	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RX821002	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RX821002	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RX821002	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		185	10778	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	10778	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	10778	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	10778	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		135398745	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		484	9633	51	35S-GTPGammaS	-9	35	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	35S-GTPGammaS	-9	35	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	35S-GTPGammaS	-9	35	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		68602	211905	80	35S-GTPGammaS	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	211905	80	35S-GTPGammaS	-1	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		None	222738	0	3H-RAUWOLSCINE	-2	6	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	358	4	0	3	2.8	CCCS(=O)(=O)N(C)C1CCN2CCC3=CC=CC=C3C2C1.Cl	None
		123981	23231	22	3H-RAUWOLSCINE	-2	8	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	None
		CHEMBL123349	23231	22	3H-RAUWOLSCINE	-2	8	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	None
		CHEMBL536803	23231	22	3H-RAUWOLSCINE	-2	8	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	None
		2142	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	9870	58	3H-RX821002	-1	37	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RX821002	-1	37	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RX821002	-1	37	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RX821002	-1	37	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RX821002	-1	37	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RX821002	-1	37	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		1816	9318	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	9318	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	9318	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	9318	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	9318	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		1343	8670	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	8670	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	8670	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	8670	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	8670	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		2142	9870	58	35S-GTPGammaS	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	35S-GTPGammaS	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	35S-GTPGammaS	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	35S-GTPGammaS	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	35S-GTPGammaS	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	35S-GTPGammaS	-2	37	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		11079	9510	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	9510	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	9510	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	9510	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	9510	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	9510	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		25137849	222958	0	3H-CLONIDINE	-2	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	222958	0	3H-CLONIDINE	-2	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		11750482	154199	0	UNDEFINED	-25	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	None
		CHEMBL392991	154199	0	UNDEFINED	-25	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	None
		3952	8669	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	8669	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	8669	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	8669	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	8669	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	8669	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		2435	7509	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		395	7509	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		520	7509	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5386	7509	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		CHEMBL844	7509	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		DB00484	7509	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		4209	9937	75	3H-RAUWOLSCINE	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	3H-RAUWOLSCINE	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	3H-RAUWOLSCINE	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	3H-RAUWOLSCINE	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	3H-RAUWOLSCINE	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	3H-RAUWOLSCINE	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		44438161	153919	0	UNDEFINED	-22	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	None
		CHEMBL392771	153919	0	UNDEFINED	-22	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	None
		2337	10030	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		4209	9937	75	3H-MK912	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	3H-MK912	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	3H-MK912	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	3H-MK912	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	3H-MK912	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	3H-MK912	-1380	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		2695	10613	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		5504	10613	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		7310	10613	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		CHEMBL770	10613	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		DB00797	10613	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		2389	10104	118	3H-RAUWOLSCINE	-77	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-RAUWOLSCINE	-77	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-RAUWOLSCINE	-77	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-RAUWOLSCINE	-77	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-RAUWOLSCINE	-77	66	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3658	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		103	10925	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		523	10878	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		5707	10878	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		CHEMBL297362	10878	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		DB11477	10878	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		135398737	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2695	10613	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		5504	10613	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		7310	10613	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		CHEMBL770	10613	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		DB00797	10613	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		2803	7742	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		124	9755	47	35S-GTPGammaS	-28	32	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	35S-GTPGammaS	-28	32	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	35S-GTPGammaS	-28	32	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	35S-GTPGammaS	-28	32	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	35S-GTPGammaS	-28	32	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		3658	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	10879	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		2726	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1615	174570	24	3H-CLONIDINE	-6	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	174570	24	3H-CLONIDINE	-6	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		2726	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		44438152	100383	0	UNDEFINED	-134	3	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	None
		CHEMBL246639	100383	0	UNDEFINED	-134	3	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	None
		162265	209053	22	3H-CLONIDINE	-12	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-CLONIDINE	-12	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-CLONIDINE	-12	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		162265	209053	22	3H-CLONIDINE	-12	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-CLONIDINE	-12	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-CLONIDINE	-12	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5268	10428	40	3H-RAUWOLSCINE	-63	18	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	10428	40	3H-RAUWOLSCINE	-63	18	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	10428	40	3H-RAUWOLSCINE	-63	18	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		None	223018	0	3H-CLONIDINE	-30199	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		2216	7234	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		229	7234	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		7117	7234	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		CHEMBL647	7234	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		DB00964	7234	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		102	10899	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		68602	211905	80	3H-RX821002	-1	8	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	211905	80	3H-RX821002	-1	8	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		124	9755	47	3H-RX821002	-16	32	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-RX821002	-16	32	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-RX821002	-16	32	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-RX821002	-16	32	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-RX821002	-16	32	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		5268	10428	40	3H-RX821002	-10	18	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	10428	40	3H-RX821002	-10	18	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	10428	40	3H-RX821002	-10	18	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		68602	211905	80	35S-GTPGammaS	1	8	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	211905	80	35S-GTPGammaS	1	8	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		138107169	222731	0	3H-RAUWOLSCINE	-6	23	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-RAUWOLSCINE	-6	23	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	222737	0	3H-RAUWOLSCINE	-14	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		102	10899	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		138107169	222731	0	3H-MK912	-6	23	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	3H-MK912	-6	23	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		115237	62359	119	3H-RAUWOLSCINE	-44	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-RAUWOLSCINE	-44	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		122295	16640	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		CHEMBL114166	16640	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		4209	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		162265	209053	22	3H-CLONIDINE	-12	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-CLONIDINE	-12	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-CLONIDINE	-12	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		1212	8443	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		11225732	100432	0	UNDEFINED	-16	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	None
		CHEMBL246852	100432	0	UNDEFINED	-16	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	None
		2803	7742	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		5524	223243	0	35S-GTPGammaS	1	4	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	215	1	2	3	1.9	C1CCC2=C(C1)C=CC=C2NC3=NCCN3	None
		1212	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		135398745	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1212	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		135398745	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		4209	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	3H-RAUWOLSCINE	-1380	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		133621	8793	0	35S-GTPGammaS	-6	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	3	0	4	2.3	CCn1ccnc1CC1COc2c(O1)cccc2	None
		3470	8793	0	35S-GTPGammaS	-6	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	3	0	4	2.3	CCn1ccnc1CC1COc2c(O1)cccc2	None
		CHEMBL347695	8793	0	35S-GTPGammaS	-6	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	3	0	4	2.3	CCn1ccnc1CC1COc2c(O1)cccc2	None
		523	10878	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		5707	10878	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		CHEMBL297362	10878	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		DB11477	10878	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		122295	16640	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		CHEMBL114166	16640	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		None	223018	0	3H-CLONIDINE	-30199	29	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		122295	16640	7	3H-RX821002	-1	9	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		CHEMBL114166	16640	7	3H-RX821002	-1	9	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		2803	7742	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		124	9755	47	3H-Yohimbine	-16	32	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-Yohimbine	-16	32	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-Yohimbine	-16	32	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-Yohimbine	-16	32	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-Yohimbine	-16	32	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		138107169	222731	0	35S-GTPGammaS	-97	23	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	222731	0	35S-GTPGammaS	-97	23	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		2337	10030	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	10030	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		122211	7250	0	3H-RX821002	-229	6	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	7250	0	3H-RX821002	-229	6	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		104870	105656	47	3H-RX821002	-2	21	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	105656	47	3H-RX821002	-2	21	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	105656	47	3H-RX821002	-2	21	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		484	9633	51	3H-RX821002	-14	35	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-RX821002	-14	35	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-RX821002	-14	35	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		1524	8962	96	3H-RAUWOLSCINE	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-RAUWOLSCINE	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-RAUWOLSCINE	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-RAUWOLSCINE	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-RAUWOLSCINE	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-RAUWOLSCINE	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		122211	7250	0	3H-RAUWOLSCINE	-239	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	7250	0	3H-RAUWOLSCINE	-239	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		3337	213146	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		67409	222813	0	3H-RAUWOLSCINE	-7	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	235	2	0	1	3.9	C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1	None
		8966	222813	0	3H-RAUWOLSCINE	-7	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	235	2	0	1	3.9	C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1	None
		1028	7079	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		484	9633	51	35S-GTPGammaS	-9	35	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	35S-GTPGammaS	-9	35	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	35S-GTPGammaS	-9	35	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		104870	105656	47	35S-GTPGammaS	-2	21	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	105656	47	35S-GTPGammaS	-2	21	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	105656	47	35S-GTPGammaS	-2	21	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		24840389	121991	4	3H-RX821002	-295	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		CHEMBL334529	121991	4	3H-RX821002	-295	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		2142	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		931	223242	0	35S-GTPGammaS	-1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	128	0	0	0	2.8	C1=CC=C2C=CC=CC2=C1	None
		115237	62359	119	3H-CLONIDINE	-44	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-CLONIDINE	-44	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		135	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		12057539	214820	42	None	-9	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	None	-9	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	None	-9	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		124	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-RAUWOLSCINE	-4	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2803	7742	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		44438147	100264	0	UNDEFINED	-20	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	None
		CHEMBL246228	100264	0	UNDEFINED	-20	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	None
		10836	21239	14	3H-CLONIDINE	-2	9	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	21239	14	3H-CLONIDINE	-2	9	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		44438167	155749	0	UNDEFINED	-52	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	None
		CHEMBL394218	155749	0	UNDEFINED	-52	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	None
		2435	7509	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		395	7509	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		520	7509	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5386	7509	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		CHEMBL844	7509	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		DB00484	7509	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		100	10577	58	3H-RAUWOLSCINE	-33	54	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-RAUWOLSCINE	-33	54	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-RAUWOLSCINE	-33	54	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-RAUWOLSCINE	-33	54	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-RAUWOLSCINE	-33	54	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		44438165	173563	0	UNDEFINED	-48	3	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	None
		CHEMBL428407	173563	0	UNDEFINED	-48	3	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	None
		135	9310	43	3H-RAUWOLSCINE	-4	56	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-RAUWOLSCINE	-4	56	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-RAUWOLSCINE	-4	56	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-RAUWOLSCINE	-4	56	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-RAUWOLSCINE	-4	56	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		164512323	222810	0	3H-RAUWOLSCINE	-5	5	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RAUWOLSCINE	-5	5	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		135398745	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1353	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-RAUWOLSCINE	-190	85	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2435	7509	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		395	7509	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		520	7509	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5386	7509	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		CHEMBL844	7509	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		DB00484	7509	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5280805	92180	81	None	-28	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	Drug Central	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	None
		CHEMBL226335	92180	81	None	-28	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	Drug Central	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	None
		1210	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	7705	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		3823	56995	42	None	-40	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		76973198	56995	42	None	-40	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL157101	56995	42	None	-40	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		28417	46813	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		CHEMBL1479	46813	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		3652	53018	70	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		CHEMBL1535	53018	70	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		135	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-RAUWOLSCINE	-4	56	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1960	9632	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		439260	9632	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		505	9632	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL1437	9632	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00368	9632	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		4158	212120	21	None	-2	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	212120	21	None	-2	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	212120	21	None	-2	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		448537	167029	89	None	-33	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		CHEMBL411	167029	89	None	-33	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		2812	11551	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	11551	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		2719	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		5535	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		607	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		CHEMBL76	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		DB00608	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		10836	21239	14	None	-2	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	21239	14	None	-2	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		4209	9937	75	None	-794	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	None	-794	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	None	-794	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	None	-794	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	None	-794	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	None	-794	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		6040	222812	0	3H-RAUWOLSCINE	-4	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	233	2	0	3	2.3	C1CCN(CC1)CC2COC3=CC=CC=C3O2	None
		2337	10030	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5268	10428	40	3H-RAUWOLSCINE	-63	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	10428	40	3H-RAUWOLSCINE	-63	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	10428	40	3H-RAUWOLSCINE	-63	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		4211	64596	83	None	-1	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
		CHEMBL1670	64596	83	None	-1	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
		1443	8809	34	None	-23	11	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		33625	8809	34	None	-23	11	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		501	8809	34	None	-23	11	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		CHEMBL279516	8809	34	None	-23	11	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		DB08950	8809	34	None	-23	11	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		1549008	212459	85	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	None
		CHEMBL822	212459	85	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	None
		121850	7513	0	3H-MK912	41	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	None
		525	7513	0	3H-MK912	41	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	None
		CHEMBL216097	7513	0	3H-MK912	41	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	None
		3598	194600	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		CHEMBL496	194600	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		2402	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	10143	62	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		2247	7293	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	7293	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	7293	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	7293	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	7293	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		5198	26205	54	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	None
		CHEMBL12948	26205	54	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	None
		3117	214620	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		CHEMBL964	214620	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		4209	9937	75	None	-263	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	None	-263	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	None	-263	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	None	-263	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	None	-263	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	None	-263	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		3198	212292	76	None	-19	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	212292	76	None	-19	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	212292	76	None	-19	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		16362	9899	71	None	-501	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	None	-501	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	None	-501	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	None	-501	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	None	-501	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		5318	22348	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1200348	22348	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1221	22348	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		5353853	24758	47	None	-16	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		9556529	24758	47	None	-16	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1262	24758	47	None	-16	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1836	9370	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		3340	9370	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		5281040	9370	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		CHEMBL787	9370	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		DB00471	9370	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		4189	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		2406	107180	89	None	-16	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		CHEMBL290106	107180	89	None	-16	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		119584	9373	102	None	-2	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		1848	9373	102	None	-2	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		242	9373	102	None	-2	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		CHEMBL60889	9373	102	None	-2	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		DB11675	9373	102	None	-2	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		2484	215072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	None
		CHEMBL990	215072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	None
		2342	7386	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		331	7386	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		7124	7386	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		CHEMBL1201250	7386	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		DB00767	7386	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		2335	18620	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		8478	18620	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL1182210	18620	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL221753	18620	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		1227	9267	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	9267	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	9267	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	9267	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	9267	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	9267	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3168	16034	92	None	-123	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	16034	92	None	-123	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		1353	8692	93	None	-190	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	None	-190	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	None	-190	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	None	-190	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	None	-190	85	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1830	9368	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	9368	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	9368	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	9368	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	9368	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		3151	8244	97	None	-99	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	8244	97	None	-99	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	8244	97	None	-99	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	8244	97	None	-99	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	8244	97	None	-99	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		1782	9296	84	None	-5	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	9296	84	None	-5	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	9296	84	None	-5	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	9296	84	None	-5	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	9296	84	None	-5	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		135398737	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2803	7742	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		2105	9828	37	3H-RX821002	-13	32	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	3H-RX821002	-13	32	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	3H-RX821002	-13	32	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	3H-RX821002	-13	32	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	3H-RX821002	-13	32	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		1343	8670	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	8670	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	8670	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	8670	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	8670	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		15897	9637	0	3H-CLONIDINE	-134	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-CLONIDINE	-134	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-CLONIDINE	-134	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		11957583	222973	0	3H-Yohimbine	-	1	Pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	391	1	2	3	3.4	C1CN=C(N1)NC2=C(C=C(C=C2Cl)I)Cl.Cl	None
		2398	7741	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	7741	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	7741	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	7741	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	7741	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		6852400	222716	0	3H-RAUWOLSCINE	-131	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	222716	0	3H-RAUWOLSCINE	-131	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		3337	213146	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		5268	10428	40	3H-MK912	-63	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	10428	40	3H-MK912	-63	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	10428	40	3H-MK912	-63	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		2726	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		4158	212120	21	125I-Clonidine	-2	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	212120	21	125I-Clonidine	-2	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	212120	21	125I-Clonidine	-2	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		484	9633	51	3H-Yohimbine	-14	35	Pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-Yohimbine	-14	35	Pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-Yohimbine	-14	35	Pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		3952	8669	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	8669	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	8669	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	8669	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	8669	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	8669	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		1222	8445	49	3H-RAUWOLSCINE	-100	32	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	8445	49	3H-RAUWOLSCINE	-100	32	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	8445	49	3H-RAUWOLSCINE	-100	32	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	8445	49	3H-RAUWOLSCINE	-100	32	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	8445	49	3H-RAUWOLSCINE	-100	32	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		523	10878	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		5707	10878	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		CHEMBL297362	10878	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		DB11477	10878	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		2142	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-RAUWOLSCINE	-2	37	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		6018	17837	96	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	None
		CHEMBL117785	17837	96	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	None
		463	8187	22	None	-67	13	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		6918097	8187	22	None	-67	13	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		837	8187	22	None	-67	13	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		CHEMBL2051956	8187	22	None	-67	13	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		DB14068	8187	22	None	-67	13	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		237	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL546257	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL554190	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL7568	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		2181	9902	46	None	-58	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	None	-58	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	None	-58	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	None	-58	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	None	-58	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		1530	8963	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	8963	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	8963	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	8963	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	8963	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		4601	213526	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	213526	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	213526	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		5467	212707	43	None	-6	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	None
		CHEMBL84158	212707	43	None	-6	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	None
		1577	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	10475	110	None	-3	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		657255	205863	34	None	-10	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		CHEMBL588119	205863	34	None	-10	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		3157	8252	71	None	-61	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		7170	8252	71	None	-61	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		954	8252	71	None	-61	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		CHEMBL707	8252	71	None	-61	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		DB00590	8252	71	None	-61	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		1016	10519	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	10519	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	10519	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	10519	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	10519	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	10519	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		4011	89183	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	89183	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		26757	214757	31	None	-1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	None
		CHEMBL972	214757	31	None	-1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	None
		219050	10146	25	3H-RX821002	-38	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	10146	25	3H-RX821002	-38	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	10146	25	3H-RX821002	-38	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		240	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	7731	43	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		214	10632	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	10632	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	10632	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	10632	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	10632	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	10632	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		209	9831	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	9831	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	9831	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	9831	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	9831	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2435	10362	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1042	8362	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	8362	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	8362	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	8362	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	8362	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		2726	7706	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		134	9292	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2351	10059	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	10059	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	10059	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	10059	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	10059	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		150	9287	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		1764	9287	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		8226	9287	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		CHEMBL1201356	9287	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		DB00353	9287	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		6726	8063	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	8063	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	8063	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	8063	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	8063	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		1222	8445	49	None	-100	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	8445	49	None	-100	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	8445	49	None	-100	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	8445	49	None	-100	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	8445	49	None	-100	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		6075	156887	42	None	-11	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		CHEMBL395110	156887	42	None	-11	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		3584	10549	64	None	-251	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		5401	10549	64	None	-251	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		7302	10549	64	None	-251	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		CHEMBL611	10549	64	None	-251	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		DB01162	10549	64	None	-251	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		2398	7741	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	7741	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	7741	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	7741	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	7741	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		66265	100788	15	None	-1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	100788	15	None	-1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		4735	201894	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL361506	201894	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL55	201894	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		1225	8253	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	8253	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	8253	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	8253	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	8253	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		2865	10915	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		41	8440	0	3H-RX821002	-5	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	8440	0	3H-RX821002	-5	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	8440	0	3H-RX821002	-5	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		2142	9870	58	3H-PRAZOSIN	-2	37	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-PRAZOSIN	-2	37	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-PRAZOSIN	-2	37	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-PRAZOSIN	-2	37	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-PRAZOSIN	-2	37	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-PRAZOSIN	-2	37	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		102	10899	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		191	7191	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	7191	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	7191	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	7191	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	7191	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		3561	25849	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		CHEMBL1289	25849	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		4098	39279	30	None	-13	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	39279	30	None	-13	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	39279	30	None	-13	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		164512323	222810	0	3H-RAUWOLSCINE	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RAUWOLSCINE	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		441383	27105	57	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL1306	27105	57	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		1548955	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		135398745	9688	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1212	8443	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3389	224490	0	None	-1	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		46780481	114308	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		3191	109635	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	109635	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		1028	7079	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		1971	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		162265	209053	22	None	-12	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	None	-12	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	None	-12	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		213	10625	55	None	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	None	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	None	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	None	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	None	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2286	9957	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2695	10613	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		5504	10613	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		7310	10613	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		CHEMBL770	10613	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		DB00797	10613	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		2162	48288	100	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	None
		CHEMBL1491	48288	100	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	None
		12488	8438	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		941361	8438	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		CHEMBL30008	8438	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		DB04841	8438	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		2520	210787	70	None	-6	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		CHEMBL1280	210787	70	None	-6	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		CHEMBL6966	210787	70	None	-6	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		4209	9937	75	None	-1380	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	None	-1380	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	None	-1380	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	None	-1380	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	None	-1380	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	None	-1380	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		1201549	7384	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	7384	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	7384	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	7384	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	7384	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	7384	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		103	10925	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		11057	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		1547484	7727	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	7727	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	7727	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	7727	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	7727	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		3294	8787	111	None	-47	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	None	-47	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	None	-47	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	None	-47	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	None	-47	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		12574	9383	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		4810	9383	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		CHEMBL19236	9383	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		DB09242	9383	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		1613	9127	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		15387	52596	55	None	-1	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	52596	55	None	-1	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		5472	212597	75	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	None
		CHEMBL1717	212597	75	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	None
		CHEMBL833	212597	75	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	None
		100	10577	58	None	-33	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	None	-33	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	None	-33	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	None	-33	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	None	-33	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		180	7189	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2284	9956	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	9956	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	9956	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	9956	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	9956	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		228	7233	28	None	-5	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	7233	28	None	-5	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	7233	28	None	-5	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	7233	28	None	-5	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	7233	28	None	-5	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		104870	105656	47	None	-2	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	105656	47	None	-2	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	105656	47	None	-2	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		68617	212306	62	None	-3	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	212306	62	None	-3	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	212306	62	None	-3	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		4209	9937	75	None	-74	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	None	-74	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	None	-74	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	None	-74	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	None	-74	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	None	-74	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		277	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		15897	9637	0	3H-CLONIDINE	-134	36	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-CLONIDINE	-134	36	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-CLONIDINE	-134	36	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		2803	7742	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		2803	7742	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		102	10899	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2683	10606	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		5487	10606	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		7308	10606	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		CHEMBL1079	10606	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		DB00697	10606	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		102	10899	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2726	7706	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2435	10362	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2435	10362	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1028	7079	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		214	10632	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	10632	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	10632	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	10632	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	10632	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	10632	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		None	223104	0	3H-CLONIDINE	-8	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		2202	9906	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	9906	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	9906	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	9906	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	9906	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		212	10578	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	10578	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	10578	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	10578	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	10578	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		242	7258	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		135398737	7745	93	None	-26	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-26	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-26	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-26	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-26	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		26987	7736	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	7736	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	7736	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	7736	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	7736	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		1960	9632	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		439260	9632	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		505	9632	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL1437	9632	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00368	9632	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		2274	9947	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	9947	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	9947	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	9947	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	9947	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		124	9755	47	35S-GTPGammaS	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	35S-GTPGammaS	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	35S-GTPGammaS	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	35S-GTPGammaS	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	35S-GTPGammaS	-4	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2105	9828	37	None	-13	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	None	-13	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	None	-13	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	None	-13	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	None	-13	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		117590588	103299	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	None
		14969	103299	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	None
		CHEMBL262777	103299	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	None
		102	10899	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		213046	9164	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		4168	9164	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		7461	9164	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		CHEMBL1237021	9164	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		DB08815	9164	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		2585	7590	103	None	-28	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		522	7590	103	None	-28	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		551	7590	103	None	-28	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		CHEMBL723	7590	103	None	-28	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		DB01136	7590	103	None	-28	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		68712	107114	60	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	Drug Central	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		CHEMBL289480	107114	60	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	Drug Central	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		5524	223243	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	215	1	2	3	1.9	C1CCC2=C(C1)C=CC=C2NC3=NCCN3	None
		240	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	7731	43	None	-3	25	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2389	10104	118	None	-37	66	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	None	-37	66	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	None	-37	66	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	None	-37	66	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	None	-37	66	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6761	74574	19	None	-6	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL1909072	74574	19	None	-6	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		133	9274	52	None	-23	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	None	-23	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	None	-23	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	None	-23	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	None	-23	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		124	9755	47	None	-16	32	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	None	-16	32	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	None	-16	32	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	None	-16	32	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	None	-16	32	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		11079	9510	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	9510	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	9510	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	9510	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	9510	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	9510	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		1816	9318	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	9318	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	9318	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	9318	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	9318	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		135398737	7745	93	None	-10	90	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-10	90	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-10	90	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-10	90	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-10	90	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		931	223242	0	35S-GTPGammaS	-2	4	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	128	0	0	0	2.8	C1=CC=C2C=CC=CC2=C1	None
		135	9310	43	None	-5	56	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	None	-5	56	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	None	-5	56	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	None	-5	56	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	None	-5	56	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		3952	8669	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	8669	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	8669	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	8669	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	8669	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	8669	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		11978813	7508	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	7508	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	7508	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	7508	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	7508	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		3658	10879	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	10879	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	10879	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	10879	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	10879	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		10219	195575	37	None	-1	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	None
		CHEMBL493439	195575	37	None	-1	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	None
		CHEMBL50588	195575	37	None	-1	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	None
		129211	10521	78	None	-120	16	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		2562	10521	78	None	-120	16	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		488	10521	78	None	-120	16	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		CHEMBL836	10521	78	None	-120	16	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		DB00706	10521	78	None	-120	16	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		37	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		460	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		54746	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		CHEMBL1201087	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		DB00248	7565	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		115237	62359	119	None	-44	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	None	-44	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2216	7234	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		229	7234	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		7117	7234	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		CHEMBL647	7234	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		DB00964	7234	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		41	8440	0	3H-MK912	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		41	8440	0	3H-RX821002	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	8440	0	3H-MK912	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	8440	0	3H-RX821002	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	8440	0	3H-MK912	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	8440	0	3H-RX821002	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		102	10899	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	223108	0	3H-CLONIDINE	2	27	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		68712	107114	60	35S-GTPGammaS	-9	5	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		CHEMBL289480	107114	60	35S-GTPGammaS	-9	5	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		None	222914	0	3H-CLONIDINE	-758	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		213	10625	55	125I-Clonidine	-10	43	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	125I-Clonidine	-10	43	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	125I-Clonidine	-10	43	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	125I-Clonidine	-10	43	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	125I-Clonidine	-10	43	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		242	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		119570	9933	96	3H-CLONIDINE	-41	39	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-CLONIDINE	-41	39	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-CLONIDINE	-41	39	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-CLONIDINE	-41	39	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-CLONIDINE	-41	39	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2726	7706	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-RAUWOLSCINE	-26	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11954259	222758	0	3H-CLONIDINE	-263	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		4209	9937	75	35S-GTPGammaS	-1380	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	9937	75	35S-GTPGammaS	-1380	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	9937	75	35S-GTPGammaS	-1380	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	9937	75	35S-GTPGammaS	-1380	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	9937	75	35S-GTPGammaS	-1380	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	9937	75	35S-GTPGammaS	-1380	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		31101	7516	40	None	-10	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	None	-10	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	None	-10	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	None	-10	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	None	-10	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		2389	10104	118	None	-77	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	None	-77	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	None	-77	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	None	-77	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	None	-77	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		12575	8769	30	UNDEFINED	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	8769	30	UNDEFINED	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	8769	30	UNDEFINED	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1209	8439	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	8439	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	8439	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	8439	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	8439	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		5268	10428	40	3H-RAUWOLSCINE	-63	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	10428	40	3H-RAUWOLSCINE	-63	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	10428	40	3H-RAUWOLSCINE	-63	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		135	9310	43	None	-4	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	None	-4	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	None	-4	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	None	-4	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	None	-4	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2142	9870	58	None	-2	37	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	None	-2	37	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	None	-2	37	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	None	-2	37	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	None	-2	37	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	None	-2	37	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		102	10899	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1593	9119	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		30668	9119	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		9868	9119	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		CHEMBL17860	9119	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		DB04948	9119	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		2803	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		134551	7146	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	7146	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	7146	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	7146	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		2216	7234	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		229	7234	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		7117	7234	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		CHEMBL647	7234	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		DB00964	7234	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		None	222814	0	3H-RAUWOLSCINE	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	200	3	1	1	2.8	CC1=C(C(=CC=C1)C)CCC2=CN=CN2	None
		2142	9870	58	None	-2	37	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	None	-2	37	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	None	-2	37	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	None	-2	37	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	None	-2	37	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	None	-2	37	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		124	9755	47	None	-5	32	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	None	-5	32	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	None	-5	32	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	None	-5	32	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	None	-5	32	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		164512323	222810	0	3H-RAUWOLSCINE	-5	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	222810	0	3H-RAUWOLSCINE	-5	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		11954259	222758	0	3H-CLONIDINE	-263	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		3337	213146	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		209	9831	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	9831	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	9831	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	9831	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	9831	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2803	7742	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		11293787	154992	0	UNDEFINED	-77	3	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	None
		CHEMBL393597	154992	0	UNDEFINED	-77	3	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	None
		2181	9902	46	3H-RAUWOLSCINE	-58	34	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	3H-RAUWOLSCINE	-58	34	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	3H-RAUWOLSCINE	-58	34	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	3H-RAUWOLSCINE	-58	34	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	3H-RAUWOLSCINE	-58	34	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		2202	9906	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	9906	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	9906	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	9906	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	9906	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		None	223109	0	UNDEFINED	-8	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		2142	9870	58	None	1	37	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	None	1	37	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	None	1	37	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	None	1	37	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	None	1	37	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	None	1	37	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		11954224	222732	0	None	-446	59	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		107715	207724	22	None	-6	20	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL1255837	207724	22	None	-6	20	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL601773	207724	22	None	-6	20	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		931	223242	0	35S-GTPGammaS	-2	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	128	0	0	0	2.8	C1=CC=C2C=CC=CC2=C1	None
		102	10899	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2803	7742	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	7742	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	7742	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	7742	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	7742	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		10531	8202	21	None	-5	24	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	8202	21	None	-5	24	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	8202	21	None	-5	24	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	8202	21	None	-5	24	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	8202	21	None	-5	24	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		2601	10552	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		124	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	9755	47	3H-MK912	-4	32	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	9755	47	3H-MK912	-4	32	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	9755	47	3H-MK912	-4	32	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	9755	47	3H-MK912	-4	32	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	9755	47	3H-MK912	-4	32	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		12575	8769	30	35S-GTPGammaS	-5	17	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	8769	30	35S-GTPGammaS	-5	17	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	8769	30	35S-GTPGammaS	-5	17	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1588	9105	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1576	223105	0	3H-CLONIDINE	-15	40	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		1343	8670	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	8670	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	8670	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	8670	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	8670	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		None	223109	0	3H-CLONIDINE	-8	27	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		21830793	98610	10	3H-8-OH-DPAT	-630	46	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	98610	10	3H-8-OH-DPAT	-630	46	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		None	222815	0	3H-RAUWOLSCINE	-16	3	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	334	4	1	4	4.6	CN(C)CCCN1C2=C(C=C(C=C2)O)SC3=C1C=C(C=C3)Cl	None
		484	9633	51	3H-RAUWOLSCINE	-9	35	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-RAUWOLSCINE	-9	35	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-RAUWOLSCINE	-9	35	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		1593	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		30668	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		9868	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		CHEMBL17860	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		DB04948	9119	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		1816	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		1816	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		4205	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		4205	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		7241	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		7241	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		CHEMBL654	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		CHEMBL654	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		DB00370	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		DB00370	9318	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		2695	10613	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		5504	10613	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		7310	10613	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		CHEMBL770	10613	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		DB00797	10613	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		174174	7311	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		260	7311	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		320	7311	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		CHEMBL517712	7311	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		DB00572	7311	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		12574	9383	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		4810	9383	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		CHEMBL19236	9383	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		DB09242	9383	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		523	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		523	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		5707	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		5707	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		CHEMBL297362	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		CHEMBL297362	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		DB11477	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		DB11477	10878	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		1960	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		1960	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		1960	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		439260	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		439260	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		439260	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		505	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		505	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		505	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		CHEMBL1437	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		CHEMBL1437	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		CHEMBL1437	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		DB00368	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		DB00368	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		DB00368	9632	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		1028	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		1028	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		1028	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		139148732	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		139148732	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		139148732	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		479	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		479	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		479	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		5816	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		5816	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		5816	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		CHEMBL679	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		CHEMBL679	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		CHEMBL679	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		DB00668	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		DB00668	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		DB00668	7079	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		4209	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		4209	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		4209	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		4893	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		4893	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		4893	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		503	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		503	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		503	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		5385	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		5385	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		5385	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		CHEMBL2	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		CHEMBL2	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		CHEMBL2	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		DB00457	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		DB00457	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		DB00457	9937	75	None	-1380	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		2683	10606	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		5487	10606	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		7308	10606	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		CHEMBL1079	10606	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		DB00697	10606	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		2726	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		2726	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		2726	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		621	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		621	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		621	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		83	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		83	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		83	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		CHEMBL71	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		CHEMBL71	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		CHEMBL71	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		DB00477	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		DB00477	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		DB00477	7706	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		122211	7250	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	1353247
		122211	7250	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	35224877
		122211	7250	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	7908642
		524	7250	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	1353247
		524	7250	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	35224877
		524	7250	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	7908642
		1343	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		1343	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		1343	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		3519	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		3519	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		3519	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		522	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		522	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		522	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		CHEMBL862	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		CHEMBL862	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		CHEMBL862	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		DB01018	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		DB01018	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		DB01018	8670	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		11079	9510	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		3369	9510	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		4436	9510	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		5509	9510	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		CHEMBL761	9510	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		DB06711	9510	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		213046	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		213046	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		4168	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		4168	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		7461	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		7461	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		CHEMBL1237021	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		CHEMBL1237021	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		DB08815	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		DB08815	9164	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		5268	10428	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	35224877
		5268	10428	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	7996470
		53	10428	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	35224877
		53	10428	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	7996470
		CHEMBL300555	10428	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	35224877
		CHEMBL300555	10428	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	7996470
		12575	8769	30	None	-5	17	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	35224877
		54459	8769	30	None	-5	17	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	35224877
		CHEMBL10316	8769	30	None	-5	17	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	35224877
		2389	10104	118	None	-77	66	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		5073	10104	118	None	-77	66	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		96	10104	118	None	-77	66	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		CHEMBL85	10104	118	None	-77	66	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		DB00734	10104	118	None	-77	66	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		3952	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		3952	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		5353646	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		5353646	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		5443	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		5443	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		5702063	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		5702063	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		CHEMBL1331786	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		CHEMBL1331786	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		CHEMBL420	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		CHEMBL420	8669	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		13180	7550	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	13	2	4	7.4	C(CCCCCNC1=C2C=CC=CC2=NC=C1)CCCCNC3=CC=NC4=C3C=CC=C4	32694911
		151782	7550	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	13	2	4	7.4	C(CCCCCNC1=C2C=CC=CC2=NC=C1)CCCCNC3=CC=NC4=C3C=CC=C4	32694911
		CHEMBL121656	7550	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	13	2	4	7.4	C(CCCCCNC1=C2C=CC=CC2=NC=C1)CCCCNC3=CC=NC4=C3C=CC=C4	32694911
		2435	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		2435	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		2435	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		2435	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		2435	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		395	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		395	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		395	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		395	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		395	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		520	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		520	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		520	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		520	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		520	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		5386	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		5386	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		5386	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		5386	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		5386	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		CHEMBL844	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		CHEMBL844	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		CHEMBL844	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		CHEMBL844	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		CHEMBL844	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		DB00484	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		DB00484	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		DB00484	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		DB00484	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		DB00484	7509	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		3658	10879	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		517	10879	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		5709	10879	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		CHEMBL312448	10879	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		DB06694	10879	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		2142	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		2142	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		2142	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		4920903	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		4920903	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		4920903	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		502	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		502	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		502	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		5775	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		5775	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		5775	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		CHEMBL597	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		CHEMBL597	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		CHEMBL597	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		DB00692	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		DB00692	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		DB00692	9870	58	None	-2	37	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		2803	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		2803	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		2803	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		2803	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		516	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		516	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		516	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		516	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		704	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		704	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		704	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		704	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		CHEMBL134	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		CHEMBL134	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		CHEMBL134	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		CHEMBL134	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		DB00575	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		DB00575	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		DB00575	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		DB00575	7742	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		124	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		124	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		124	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		124	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		2032	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		2032	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		2032	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		2032	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		4636	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		4636	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		4636	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		4636	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		CHEMBL762	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		CHEMBL762	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		CHEMBL762	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		CHEMBL762	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		DB00935	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		DB00935	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		DB00935	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		DB00935	9755	47	None	-4	32	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		121850	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	2573535
		121850	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	35224877
		121850	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	7996470
		525	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	2573535
		525	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	35224877
		525	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	7996470
		CHEMBL216097	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	2573535
		CHEMBL216097	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	35224877
		CHEMBL216097	7513	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	7996470
		31101	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		31101	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		35	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		35	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		403	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		403	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		CHEMBL493	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		CHEMBL493	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		DB01200	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		DB01200	7516	40	None	-10	35	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		499	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	1353247
		499	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	35224877
		499	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	7908642
		5685	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	1353247
		5685	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	35224877
		5685	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	7908642
		CHEMBL25554	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	1353247
		CHEMBL25554	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	35224877
		CHEMBL25554	10849	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	7908642
		313	9468	0	None	-2	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	29860464
		2216	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		229	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		7117	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		CHEMBL647	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		DB00964	7234	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		12576	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		71310	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		CHEMBL353972	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		DB11481	7302	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		521	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		521	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		521	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		521	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		521	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		5311068	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		5311068	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		5311068	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		5311068	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		5311068	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		835	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		835	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		835	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		835	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		835	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		CHEMBL778	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		CHEMBL778	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		CHEMBL778	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		CHEMBL778	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		CHEMBL778	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		DB00633	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		DB00633	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		DB00633	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		DB00633	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		DB00633	8186	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		108094	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		108094	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		526	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		526	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		528	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		528	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		CHEMBL10332	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		CHEMBL10332	10196	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		12577	9341	0	None	-15	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	0	0	3	3.3	CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C	35224877
		189711	9341	0	None	-15	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	0	0	3	3.3	CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C	35224877
		CHEMBL1257057	9341	0	None	-15	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	0	0	3	3.3	CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C	35224877
		102	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		102	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		102	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		102	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		3659	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		3659	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		3659	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		3659	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		8969	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		8969	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		8969	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		8969	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		CHEMBL15245	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		CHEMBL15245	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		CHEMBL15245	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		CHEMBL15245	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		DB01392	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		DB01392	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		DB01392	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		DB01392	10899	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		13128	10173	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	364	3	0	4	2.4	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC	35224877
		9908992	10173	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	364	3	0	4	2.4	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC	35224877
		CHEMBL4303564	10173	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	364	3	0	4	2.4	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC	35224877
		1588	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		1588	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		28864	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		28864	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		43	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		43	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		CHEMBL157138	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL157138	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		DB00589	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB00589	9105	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		2995	211184	53	None	-12	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	None	-12	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	None	-12	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		179	7188	115	None	-35	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	None	-35	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	None	-35	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	None	-35	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	None	-35	50	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		3337	213146	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		119570	9933	96	None	-41	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	None	-41	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	None	-41	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	None	-41	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	None	-41	39	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		46780481	114308	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		228	7233	28	None	-5	23	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		33	7233	28	None	-5	23	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		6005	7233	28	None	-5	23	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		CHEMBL53	7233	28	None	-5	23	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		DB00714	7233	28	None	-5	23	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		2202	9906	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		4850	9906	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		49	9906	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		CHEMBL1371770	9906	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		DB12478	9906	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		2105	9828	37	None	-13	32	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		47811	9828	37	None	-13	32	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		48	9828	37	None	-13	32	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		CHEMBL531	9828	37	None	-13	32	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		DB01186	9828	37	None	-13	32	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		37	7565	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		460	7565	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		54746	7565	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		CHEMBL1201087	7565	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		DB00248	7565	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		136	10065	32	None	-3	16	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		223	10065	32	None	-3	16	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		643606	10065	32	None	-3	16	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		CHEMBL10347	10065	32	None	-3	16	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		2601	10552	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		443951	10552	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		56	10552	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL73151	10552	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB13399	10552	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666

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Ligand source activities (1 row/activity)