Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	216416	111581	48	None	-117	23	Human	5.0	pAC50	=	5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111581	48	None	-117	23	Human	5.0	pAC50	=	5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	319	1324	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1324	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1324	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1324	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1324	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1324	44	None	-3715	18	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	11504295	2923	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	47	None	-75857	8	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4151	3607	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	493	3607	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125	3607	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL24778	3607	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	DB06207	3607	89	None	-1819	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	2855	4132	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	104	None	-5011	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	4066	204626	78	None	-630	16	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204626	78	None	-630	16	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	242	470	124	None	-72	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-72	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-72	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-72	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-72	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	37	778	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-89	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	6230	10320	63	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	0	1	2	3.5	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1162	10320	63	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	0	1	2	3.5	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	4746	204891	31	None	-10	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204891	31	None	-10	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204891	31	None	-10	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	134	2514	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	24	None	-1819	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	2335	11848	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11848	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11848	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11848	22	None	-52	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	60606	61560	73	None	-5	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61560	73	None	-5	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	27812	66991	43	None	1	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1868702	66991	43	None	1	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	2472	67284	48	None	-19	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	1	7	2.1	CCCC(=O)N1CCCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1	10.1038/s41467-023-40064-9
	CHEMBL188185	67284	48	None	-19	4	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	1	7	2.1	CCCC(=O)N1CCCN(c2nc(N)c3cc(OC)c(OC)cc3n2)CC1	10.1038/s41467-023-40064-9
	5639	98895	75	None	-218	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98895	75	None	-218	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	447715	196927	68	None	-18	7	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	196927	68	None	-18	7	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1028	291	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	71	None	-10	19	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2683	3834	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	5487	3834	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	7308	3834	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	CHEMBL1079	3834	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	DB00697	3834	60	None	-1	6	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	68617	205527	62	None	-10	30	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205527	62	None	-10	30	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205527	62	None	-10	30	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	10219	188796	37	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL493439	188796	37	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL50588	188796	37	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	102	4127	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	48	None	2	20	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	168871	89130	14	None	-9	13	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-9	13	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	17676	7072	29	None	-275	13	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7072	29	None	-275	13	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7072	29	None	-275	13	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5472	205818	75	None	-1	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	205818	75	None	-1	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	205818	75	None	-1	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	26248	161539	102	None	-1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161539	102	None	-1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	31703	194717	63	None	-19	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194717	63	None	-19	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194717	63	None	-19	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2402	3370	62	None	-616	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	62	None	-616	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	62	None	-616	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	62	None	-616	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	62	None	-616	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	441074	19414	82	None	-9	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19414	82	None	-9	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	1353	1911	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	93	None	-2884	39	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3149	12614	15	None	-35	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12614	15	None	-35	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	3316	31760	71	None	-23	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31760	71	None	-23	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	636403	188268	22	None	-5	7	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188268	22	None	-5	7	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	179	400	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	2159	400	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	963	400	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	CHEMBL243712	400	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	DB06288	400	115	None	-1905	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	68712	100338	60	None	1	7	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	CHEMBL289480	100338	60	None	1	7	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	2105	3054	37	None	-125	25	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	37	None	-125	25	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	37	None	-125	25	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	37	None	-125	25	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	37	None	-125	25	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	11079	2733	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2733	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2733	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2733	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2733	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2733	63	None	-5	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3157	1470	71	None	-5370	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	71	None	-5370	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	71	None	-5370	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	71	None	-5370	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	71	None	-5370	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	1212	1662	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1662	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1662	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1662	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1662	50	None	-891	35	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	119570	3159	96	None	-7762	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3159	96	None	-7762	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3159	96	None	-7762	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3159	96	None	-7762	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3159	96	None	-7762	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	4209	3163	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	75	None	-19952	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	2780	110529	36	None	-1479	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110529	36	None	-1479	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	5453	203619	102	None	-323	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203619	102	None	-323	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	4477	36536	90	None	-13	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	36536	90	None	-13	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	214	3860	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	58	None	-467	28	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	11626560	200937	94	None	-16	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200937	94	None	-16	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	135398737	958	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	93	None	-112	43	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1593	2340	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668	2340	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	9868	2340	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL17860	2340	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	DB04948	2340	66	None	1	6	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	1816	2540	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	102	None	-39	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	2146	3100	67	None	-123	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3100	67	None	-123	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3100	67	None	-123	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3100	67	None	-123	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3100	67	None	-123	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	13314	84233	15	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	84233	15	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	2142	3096	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	58	None	-11	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	2343	14454	57	None	-1	4	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
	CHEMBL1201039	14454	57	None	-1	4	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
	150	2509	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	21	None	-2041	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	392622	56312	95	None	-14	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56312	95	None	-14	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	68602	205126	80	None	-10	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
	CHEMBL77921	205126	80	None	-10	4	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
	1201549	597	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	24	None	-1584	26	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	6018	11065	96	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	11065	96	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	2601	3780	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	33	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	4567	9948	34	None	-239	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9948	34	None	-239	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	41684	31221	105	None	-42	32	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31221	105	None	-42	32	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	25102847	78221	93	None	-15	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78221	93	None	-15	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	443955	204370	92	None	-17	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204370	92	None	-17	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	16363	596	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	53	None	-3630	21	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2435	722	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	395	722	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	520	722	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5386	722	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL844	722	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	DB00484	722	100	None	7	10	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	82153	43901	45	None	-41	3	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	CHEMBL1512	43901	45	None	-41	3	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	11980903	14492	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14492	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14492	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14492	19	None	-549	25	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	610479	15500	90	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	15500	90	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	2448	99323	70	None	-912	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99323	70	None	-912	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	1830	2590	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	44	None	-123	11	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	3081361	93934	123	None	-3	14	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93934	123	None	-3	14	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	2318	154856	29	None	-32	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154856	29	None	-32	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	154257	178619	67	None	-10	19	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-10	19	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	10102	2546	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	1824	2546	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906	2546	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	CHEMBL94454	2546	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	DB12523	2546	88	None	-2089	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	4260	52558	31	None	-20	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	CHEMBL159226	52558	31	None	-20	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	53276	95034	53	None	-1	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	CHEMBL255044	95034	53	None	-1	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	5329102	194726	86	None	-138	37	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194726	86	None	-138	37	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	4452	2762	19	None	-8317	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	19	None	-8317	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	19	None	-8317	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	6337614	12996	54	None	-22	6	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1189679	12996	54	None	-22	6	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
	1234	189221	56	None	-95	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189221	56	None	-95	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189221	56	None	-95	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	65859	19049	88	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	236	4	2	4	0.2	OC[C@@H](O)CN1CCN(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1288810	19049	88	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	236	4	2	4	0.2	OC[C@@H](O)CN1CCN(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	47979	78210	59	None	-8709	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78210	59	None	-8709	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	68712	100338	60	None	1	7	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	CHEMBL289480	100338	60	None	1	7	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	1960	2857	67	None	-12	18	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2857	67	None	-12	18	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2857	67	None	-12	18	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2857	67	None	-12	18	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2857	67	None	-12	18	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	4031	99313	28	None	-4	12	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	99313	28	None	-4	12	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	31508	97218	38	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	3	4.0	Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1	10.1038/s41467-023-40064-9
	CHEMBL268501	97218	38	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	3	4.0	Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1	10.1038/s41467-023-40064-9
	2146	3100	67	None	-123	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3100	67	None	-123	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3100	67	None	-123	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3100	67	None	-123	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3100	67	None	-123	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	5284550	41721	15	None	-1513	16	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41721	15	None	-1513	16	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	5210	33338	48	None	-7	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	33338	48	None	-7	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	33338	48	None	-7	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	1043	1582	14	None	-128	22	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1582	14	None	-128	22	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1582	14	None	-128	22	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1582	14	None	-128	22	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1582	14	None	-128	22	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	10133	910	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	910	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	910	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	910	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	910	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	910	78	None	1	4	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	2585	803	103	None	-512	33	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	103	None	-512	33	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	103	None	-512	33	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	103	None	-512	33	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	103	None	-512	33	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2136	3095	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	30	None	-2	21	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	103	4153	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	61	None	-323	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	65700	78260	28	None	-9	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78260	28	None	-9	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	213	3853	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	55	None	-177	22	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	68555	103112	21	None	-79	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	103112	21	None	-79	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	2803	955	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	516	955	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	704	955	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	CHEMBL134	955	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	DB00575	955	58	None	-6	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	47319	26464	35	None	-1	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1360	26464	35	None	-1	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	2407	3372	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	76	None	-1122	17	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	4418	34222	85	None	-19	18	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34222	85	None	-19	18	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	10531	1420	21	None	-14	25	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	21	None	-14	25	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	21	None	-14	25	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	21	None	-14	25	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	21	None	-14	25	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2333	142335	97	None	-3	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	-3	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	228	445	28	None	-724	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	28	None	-724	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	28	None	-724	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	28	None	-724	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	28	None	-724	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	3689	102771	55	None	-549	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102771	55	None	-549	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102771	55	None	-549	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2389	3331	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	118	None	-95	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2583	3776	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	118	None	-2238	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	2220	3134	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	-549	17	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	1960	2857	67	None	-12	18	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2857	67	None	-12	18	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2857	67	None	-12	18	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2857	67	None	-12	18	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2857	67	None	-12	18	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	11079	2733	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2733	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2733	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2733	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2733	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2733	63	None	-5	7	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	108000	56853	39	None	-12	5	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	56853	39	None	-12	5	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	56853	39	None	-12	5	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	47936	193422	88	None	-91	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193422	88	None	-91	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	2713	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205271	82	None	-8	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	3294	2006	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	111	None	-177	23	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2470	3653	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-69183	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	129211	3749	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3749	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3749	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3749	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3749	78	None	-4265	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	213046	2385	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	59	None	-35	17	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2733	27813	112	None	1	3	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	0	1	2	1.8	O=c1[nH]c2cc(Cl)ccc2o1	10.1038/s41467-023-40064-9
	CHEMBL1371	27813	112	None	1	3	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	169	0	1	2	1.8	O=c1[nH]c2cc(Cl)ccc2o1	10.1038/s41467-023-40064-9
	1343	1889	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	62	None	-3	12	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	135409453	3773	41	None	-398	35	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	41	None	-398	35	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	41	None	-398	35	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	4011	82408	49	None	-389	26	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82408	49	None	-389	26	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2202	3132	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3132	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3132	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3132	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3132	96	None	16	10	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	212	3806	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	47	None	-776	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	3658	4107	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	53	None	-1	18	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2467	67425	51	None	-1	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	CHEMBL188921	67425	51	None	-1	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	31101	729	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-48	29	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	1890	2759	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	49	None	-23	24	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	3926	207241	40	None	-10	18	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207241	40	None	-10	18	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	25382	9157	37	None	-181	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9157	37	None	-181	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	115	343	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	2092	343	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	7109	343	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	CHEMBL709	343	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	DB00346	343	71	None	-123	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	119570	3159	96	None	-7762	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3159	96	None	-7762	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3159	96	None	-7762	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3159	96	None	-7762	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3159	96	None	-7762	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	445643	97389	69	None	1	7	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97389	69	None	1	7	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	11658860	2344	51	None	-630	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	51	None	-630	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	51	None	-630	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	51	None	-630	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	51	None	-630	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	5311507	194815	41	None	-645	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194815	41	None	-645	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	2342	599	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	599	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	599	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	599	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	599	39	None	-4	8	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	4640	78266	30	None	-61	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78266	30	None	-61	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	56959	31556	103	None	-7	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31556	103	None	-7	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31556	103	None	-7	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	46780481	107531	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107531	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107531	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107531	20	None	-165	15	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	118422671	2757	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	65	None	-2691	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	104870	98880	47	None	1	10	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	98880	47	None	1	10	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	98880	47	None	1	10	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	1028	291	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	71	None	-10	19	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2695	3841	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	5504	3841	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	7310	3841	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL770	3841	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00797	3841	81	None	2	6	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	2267	559	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	71	None	-35	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	1056	3371	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	116	None	-15	10	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	54682461	84686	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84686	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	12574	2605	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810	2605	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	CHEMBL19236	2605	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	DB09242	2605	88	None	1	8	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	135	2532	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	43	None	-53	33	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1574	2313	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	5359272	2313	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	7595	2313	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	CHEMBL592	2313	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	DB00854	2313	12	None	-3388	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	124	2981	47	None	-3	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	47	None	-3	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	47	None	-3	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	47	None	-3	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	47	None	-3	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	180	401	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	56	None	-3890	38	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2169	44847	35	None	-151	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44847	35	None	-151	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	5803	162227	84	None	-2	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162227	84	None	-2	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	1971	2866	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	38	None	-3630	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2600	3779	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	74	None	-416	32	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	40326	45121	68	None	1	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	6	0	3	6.1	CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1	10.1038/s41467-023-40064-9
	CHEMBL1525	45121	68	None	1	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	6	0	3	6.1	CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1	10.1038/s41467-023-40064-9
	2470	3653	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-69183	23	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	4993	122357	110	None	-2	5	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122357	110	None	-2	5	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5365247	138429	33	None	-69	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	CHEMBL37744	138429	33	None	-69	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	2435	722	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	395	722	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	520	722	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	5386	722	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	CHEMBL844	722	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	DB00484	722	100	None	7	10	Human	9.2	pEC50	=	9.2	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
	521	1404	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	5311068	1404	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	835	1404	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	CHEMBL778	1404	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	DB00633	1404	69	None	-20	5	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	2435	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	395	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	520	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	5386	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	CHEMBL844	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	DB00484	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	218362	204800	5	None	1	3	Human	8.9	pEC50	=	8.9	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
	CHEMBL75030	204800	5	None	1	3	Human	8.9	pEC50	=	8.9	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
	185076	187090	5	None	11	3	Human	8.9	pEC50	=	8.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL49137	187090	5	None	11	3	Human	8.9	pEC50	=	8.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	521	1404	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	5311068	1404	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	835	1404	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	CHEMBL778	1404	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	DB00633	1404	69	None	-20	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1016/j.bmc.2010.11.020
	44314198	104412	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
	CHEMBL310335	104412	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
	9815707	101469	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
	CHEMBL297752	101469	0	None	2	3	Human	8.8	pEC50	=	8.8	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
	2803	955	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	516	955	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	704	955	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	CHEMBL134	955	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	DB00575	955	58	None	-6	14	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	44292232	101321	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	CHEMBL296660	101321	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	11140345	204171	0	None	-12	5	Human	7.0	pEC50	=	7	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70692	204171	0	None	-12	5	Human	7.0	pEC50	=	7	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	24906200	193156	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
	CHEMBL523048	193156	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
	11211035	85003	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
	CHEMBL223836	85003	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
	11211035	85003	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
	CHEMBL223836	85003	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
	10382537	204166	12	None	4	2	Human	7.9	pEC50	=	7.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL70676	204166	12	None	4	2	Human	7.9	pEC50	=	7.9	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	44371864	51141	0	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL157955	51141	0	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	1960	2857	67	None	-12	18	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	439260	2857	67	None	-12	18	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	505	2857	67	None	-12	18	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	CHEMBL1437	2857	67	None	-12	18	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	DB00368	2857	67	None	-12	18	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2010.11.020
	44352207	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL128168	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	44352207	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL128168	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	44352207	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
	CHEMBL128168	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
	44352207	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL128168	18856	1	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	1960	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	439260	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	505	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	CHEMBL1437	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	DB00368	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.bmc.2011.11.025
	9859437	168022	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
	CHEMBL432155	168022	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
	1960	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	439260	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	505	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	CHEMBL1437	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	DB00368	2857	67	None	-12	18	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1016/j.ejmech.2014.09.083
	50994258	60089	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	3	2	1.1	Cc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641682	60089	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	3	2	1.1	Cc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1739118	60089	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	3	2	1.1	Cc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	53323136	56577	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641690	56577	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	44312036	204565	1	None	-19	2	Human	4.8	pEC50	=	4.8	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
	CHEMBL72995	204565	1	None	-19	2	Human	4.8	pEC50	=	4.8	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
	24882007	12473	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	CHEMBL1186220	12473	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	56950526	71508	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	234	2	1	4	1.7	Clc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1928323	71508	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	234	2	1	4	1.7	Clc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1962709	71508	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	234	2	1	4	1.7	Clc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	57400570	71502	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	214	2	1	4	1.3	Cc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1928322	71502	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	214	2	1	4	1.3	Cc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	CHEMBL1962686	71502	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	214	2	1	4	1.3	Cc1cccc2cnn(CC3=NCCN3)c12	10.1016/j.bmc.2011.11.025
	44371755	48777	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL155866	48777	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	24882106	12566	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2c1cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	CHEMBL1186774	12566	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	2	3	1.0	Clc1cccc2c1cnn2N=C1NCCN1	10.1016/j.bmc.2010.11.020
	118717249	115125	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
	CHEMBL3343700	115125	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
	11098175	204170	0	None	-186	4	Human	6.7	pEC50	=	6.7	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL70691	204170	0	None	-186	4	Human	6.7	pEC50	=	6.7	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	135399666	168763	7	None	-23	6	Human	5.7	pEC50	=	5.7	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168763	7	None	-23	6	Human	5.7	pEC50	=	5.7	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	3086326	204531	22	None	13	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL72753	204531	22	None	13	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	131829	204727	15	None	37	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
	CHEMBL74283	204727	15	None	37	3	Human	8.6	pEC50	=	8.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
	44314200	102952	0	None	-9	3	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
	CHEMBL306377	102952	0	None	-9	3	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
	53324490	60092	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641681	60092	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1739173	60092	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2[nH]nc(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	10934575	204486	0	None	-229	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72441	204486	0	None	-229	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
	11140347	204533	1	None	-13	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72768	204533	1	None	-13	5	Human	7.6	pEC50	=	7.6	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	11000184	13052	0	None	-74	5	Human	6.6	pEC50	=	6.6	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1190038	13052	0	None	-74	5	Human	6.6	pEC50	=	6.6	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL540035	13052	0	None	-74	5	Human	6.6	pEC50	=	6.6	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	11173568	84641	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
	CHEMBL222371	84641	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
	135453290	133606	33	None	-1318	7	Human	5.6	pEC50	=	5.6	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133606	33	None	-1318	7	Human	5.6	pEC50	=	5.6	Functional	Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayActivity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	44449277	155183	2	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	214	2	1	2	2.5	COc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL402388	155183	2	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	214	2	1	2	2.5	COc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	68712	100338	60	None	1	7	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
	CHEMBL289480	100338	60	None	1	7	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
	44312037	204619	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	CHEMBL73392	204619	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
	2803	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	516	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	704	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	CHEMBL134	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	DB00575	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2010.11.020
	11043720	92172	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL242265	92172	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	11043720	92172	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL242265	92172	0	None	-257	3	Human	4.5	pEC50	=	4.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	124	2981	47	None	-3	24	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	2032	2981	47	None	-3	24	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	4636	2981	47	None	-3	24	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	CHEMBL762	2981	47	None	-3	24	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	DB00935	2981	47	None	-3	24	Human	8.5	pEC50	=	8.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	2803	955	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	516	955	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	704	955	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	CHEMBL134	955	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	DB00575	955	58	None	-6	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2011.11.025
	2146	3100	67	None	-123	14	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	485	3100	67	None	-123	14	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	6041	3100	67	None	-123	14	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	CHEMBL1215	3100	67	None	-123	14	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	DB00388	3100	67	None	-123	14	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	57402718	71189	2	None	3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL1956201	71189	2	None	3	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	11265631	136409	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL373535	136409	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	11097789	102998	1	None	-52	5	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL306792	102998	1	None	-52	5	Human	6.5	pEC50	=	6.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	11265631	136409	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL373535	136409	0	None	-9	3	Human	6.5	pEC50	=	6.5	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
	49836306	18575	0	None	-31	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL1276247	18575	0	None	-31	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	44449247	95414	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	228	2	1	2	2.8	COc1c(C)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL256984	95414	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	228	2	1	2	2.8	COc1c(C)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	9817256	204238	0	None	-251	2	Human	5.5	pEC50	=	5.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL71001	204238	0	None	-251	2	Human	5.5	pEC50	=	5.5	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	9971924	184226	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
	CHEMBL48341	184226	0	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
	44421258	84746	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
	CHEMBL1204386	84746	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
	CHEMBL222933	84746	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
	24882019	12568	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	2	3	0.7	Cc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	CHEMBL1186788	12568	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	215	1	2	3	0.7	Cc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.bmc.2010.11.020
	1960	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	439260	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	505	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	CHEMBL1437	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	DB00368	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm0408215
	1960	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	439260	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	505	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	CHEMBL1437	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	DB00368	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm901262f
	1960	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	439260	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	505	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	CHEMBL1437	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	DB00368	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm800250z
	1960	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	439260	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	505	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	CHEMBL1437	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	DB00368	2857	67	None	-12	18	Human	6.4	pEC50	=	6.4	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm061487a
	294234	102893	3	None	2	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
	CHEMBL305928	102893	3	None	2	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
	118717248	115124	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
	CHEMBL3343699	115124	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
	11140033	20683	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL130884	20683	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
	11108001	10872	2	None	-7	5	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aAgonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2a	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL117248	10872	2	None	-7	5	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aAgonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2a	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL540542	10872	2	None	-7	5	Human	7.4	pEC50	=	7.4	Functional	Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aAgonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2a	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	2435	722	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	395	722	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	520	722	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	5386	722	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	CHEMBL844	722	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	DB00484	722	100	None	7	10	Human	8.4	pEC50	=	8.4	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
	11360447	85001	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
	CHEMBL223829	85001	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
	10859076	13682	0	None	-83	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1194763	13682	0	None	-83	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL553276	13682	0	None	-83	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	44449276	95651	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	241	2	2	2	1.8	CNC(=O)c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257976	95651	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	241	2	2	2	1.8	CNC(=O)c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	11098175	204170	0	None	-186	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL70691	204170	0	None	-186	4	Human	6.4	pEC50	=	6.4	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	57391904	71481	2	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	200	2	1	4	1.0	c1ccc2c(c1)cnn2CC1=NCCN1	10.1016/j.bmc.2011.11.025
	CHEMBL1928316	71481	2	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	200	2	1	4	1.0	c1ccc2c(c1)cnn2CC1=NCCN1	10.1016/j.bmc.2011.11.025
	CHEMBL1962472	71481	2	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation countingAgonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintillation counting	ChEMBL	200	2	1	4	1.0	c1ccc2c(c1)cnn2CC1=NCCN1	10.1016/j.bmc.2011.11.025
	44449691	96162	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	261	2	1	2	3.6	c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1	10.1016/j.bmcl.2008.03.070
	CHEMBL260576	96162	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	261	2	1	2	3.6	c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1	10.1016/j.bmcl.2008.03.070
	24906159	187405	12	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
	CHEMBL493675	187405	12	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
	57400959	71188	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL1956200	71188	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
	11265631	136409	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL373535	136409	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
	1593	2340	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	30668	2340	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	9868	2340	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	CHEMBL17860	2340	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	DB04948	2340	66	None	1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
	11109088	204180	0	None	-14	5	Human	8.2	pEC50	=	8.2	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70751	204180	0	None	-14	5	Human	8.2	pEC50	=	8.2	Functional	Agonist potency at Alpha-2A stably expressed in CHO cells.Agonist potency at Alpha-2A stably expressed in CHO cells.	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	57395731	71190	0	None	3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	CHEMBL1956202	71190	0	None	3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
	49836305	18576	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL1276248	18576	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	24906199	187665	15	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
	CHEMBL495096	187665	15	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
	44292386	101482	0	None	-35	2	Human	7.2	pEC50	=	7.2	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	CHEMBL297827	101482	0	None	-35	2	Human	7.2	pEC50	=	7.2	Functional	Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
	17804479	95660	19	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	198	1	1	1	2.9	c1ccc2c(c1)CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL258007	95660	19	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayAgonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assay	ChEMBL	198	1	1	1	2.9	c1ccc2c(c1)CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	50994260	60091	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2c(N=C3NCCN3)n[nH]c12	10.1016/j.bmc.2010.11.020
	CHEMBL1641689	60091	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2c(N=C3NCCN3)n[nH]c12	10.1016/j.bmc.2010.11.020
	CHEMBL1739136	60091	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	235	1	3	2	1.4	Clc1cccc2c(N=C3NCCN3)n[nH]c12	10.1016/j.bmc.2010.11.020
	10333157	151238	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL396013	151238	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
	10333157	151238	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	CHEMBL396013	151238	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
	11371902	141638	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
	CHEMBL385310	141638	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
	11371902	141638	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	CHEMBL385310	141638	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
	23622576	172772	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
	CHEMBL451229	172772	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidification	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
	2803	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	516	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	704	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	CHEMBL134	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	DB00575	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
	2803	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	516	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	704	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	CHEMBL134	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	DB00575	955	58	None	-6	14	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm100977d
	10176999	103554	21	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
	CHEMBL308570	103554	21	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsEffective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
	53322686	60093	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	3	2	0.7	c1ccc2c(N=C3NCCN3)n[nH]c2c1	10.1016/j.bmc.2010.11.020
	CHEMBL1641679	60093	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	3	2	0.7	c1ccc2c(N=C3NCCN3)n[nH]c2c1	10.1016/j.bmc.2010.11.020
	CHEMBL1739201	60093	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	ChEMBL	201	1	3	2	0.7	c1ccc2c(N=C3NCCN3)n[nH]c2c1	10.1016/j.bmc.2010.11.020
	15675860	204429	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
	CHEMBL72147	204429	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateAlpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
	2683	3834	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	5487	3834	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	7308	3834	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	CHEMBL1079	3834	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	DB00697	3834	60	None	-1	6	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	24882007	12473	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
	CHEMBL1186220	12473	1	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
	132111	102995	5	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL306751	102995	5	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	132111	102995	5	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL306751	102995	5	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	123132228	156306	53	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	369	5	1	8	2.4	CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1	10.1021/acs.jmedchem.1c02148
	CHEMBL4065484	156306	53	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	369	5	1	8	2.4	CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1	10.1021/acs.jmedchem.1c02148
	11820372	13490	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	208	2	1	1	3.2	c1ccc2c(Cc3c[nH]cn3)cccc2c1	10.1021/jm00041a011
	CHEMBL1193371	13490	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	208	2	1	1	3.2	c1ccc2c(Cc3c[nH]cn3)cccc2c1	10.1021/jm00041a011
	CHEMBL544765	13490	1	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	208	2	1	1	3.2	c1ccc2c(Cc3c[nH]cn3)cccc2c1	10.1021/jm00041a011
	68602	205126	80	None	-10	4	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1021/jm00041a011
	CHEMBL77921	205126	80	None	-10	4	Human	5.5	pIC50	=	5.5	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1021/jm00041a011
	10376336	13203	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	224	2	2	2	2.6	OC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL1191106	13203	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	224	2	2	2	2.6	OC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL542155	13203	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	224	2	2	2	2.6	OC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	132111	102995	5	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	CHEMBL306751	102995	5	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.	ChEMBL	222	2	1	1	3.7	CC(c1c[nH]cn1)c1cccc2ccccc12	10.1021/jm00041a011
	132256889	190447	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	378	5	1	7	3.6	COc1cccc(F)c1CNc1ccc(-c2cnc(C)nc2C)c2nncn12	10.1021/acs.jmedchem.1c02148
	CHEMBL5178464	190447	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity against alpha2a adrenergic receptor (unknown origin)Antagonist activity against alpha2a adrenergic receptor (unknown origin)	ChEMBL	378	5	1	7	3.6	COc1cccc(F)c1CNc1ccc(-c2cnc(C)nc2C)c2nncn12	10.1021/acs.jmedchem.1c02148
	CHEMBL4755618	214041	39	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Agonist activity at adrenergic receptor alpha2a (unknown origin)Agonist activity at adrenergic receptor alpha2a (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	13305910	11836	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182155	11836	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL215421	11836	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL3741808	11836	1	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	16121006	11841	0	None	-	0	Rat	5.9	pKd	=	5.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182182	11841	0	None	-	0	Rat	5.9	pKd	=	5.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL217469	11841	0	None	-	0	Rat	5.9	pKd	=	5.9	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	499	4077	18	None	-	1	Rat	6.6	pKd	=	6.6	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	5685	4077	18	None	-	1	Rat	6.6	pKd	=	6.6	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	CHEMBL25554	4077	18	None	-	1	Rat	6.6	pKd	=	6.6	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	6603808	127522	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL214986	127522	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL36622	127522	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL3740374	127522	3	None	-	2	Rat	6.3	pKd	=	6.3	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	44417713	12422	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1185884	12422	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL439346	12422	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1	10.1021/jm060358r
	44324800	206948	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	CHEMBL91157	206948	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	44324972	163372	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	CHEMBL419316	163372	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
	44579272	187095	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
	CHEMBL491420	187095	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
	10758200	63417	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	CHEMBL179648	63417	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	44579184	190953	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	CHEMBL518592	190953	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	44579271	187094	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	CHEMBL491419	187094	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
	44579228	181654	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	CHEMBL477608	181654	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	44404321	70292	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	297	4	1	5	3.0	COc1cccc(N(NC2=NCCO2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
	CHEMBL194323	70292	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	297	4	1	5	3.0	COc1cccc(N(NC2=NCCO2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
	44579185	181814	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
	CHEMBL477816	181814	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
	44579230	181544	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
	CHEMBL476569	181544	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
	44324737	207238	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
	CHEMBL92860	207238	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Binding affinity for alpha-2A-adrenergic receptorBinding affinity for alpha-2A-adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
	44579187	189679	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
	CHEMBL515331	189679	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
	44579229	189616	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	CHEMBL514837	189616	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
	2683	3834	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	5487	3834	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	7308	3834	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	CHEMBL1079	3834	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	DB00697	3834	60	None	-1	6	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay	Drug Central	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
	1343	1889	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	3519	1889	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	522	1889	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	CHEMBL862	1889	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	DB01018	1889	62	None	-3	12	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	2435	722	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	395	722	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	520	722	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	5386	722	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	CHEMBL844	722	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	DB00484	722	100	None	7	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
	521	1404	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	5311068	1404	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	835	1404	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	CHEMBL778	1404	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	DB00633	1404	69	None	-20	5	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation countingAgonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 mins by scintillation counting	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
	523	4106	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	5707	4106	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	CHEMBL297362	4106	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	DB11477	4106	93	None	-9	5	Human	5.7	pEC50	=	5.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
	1960	2857	67	None	-12	18	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	439260	2857	67	None	-12	18	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	505	2857	67	None	-12	18	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	CHEMBL1437	2857	67	None	-12	18	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	DB00368	2857	67	None	-12	18	Human	6.7	pEC50	=	6.7	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
	1028	291	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	139148732	291	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	479	291	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	5816	291	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	CHEMBL679	291	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	DB00668	291	71	None	-10	19	Human	6.8	pEC50	=	6.8	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
	1343	1889	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	3519	1889	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	522	1889	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	CHEMBL862	1889	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	DB01018	1889	62	None	-3	12	Human	7.3	pEC50	=	7.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
	2803	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	516	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	704	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	CHEMBL134	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	DB00575	955	58	None	-6	14	Human	7.6	pEC50	=	7.6	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
	3952	1888	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	5353646	1888	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	5443	1888	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	5702063	1888	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	CHEMBL1331786	1888	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	CHEMBL420	1888	38	None	-1	21	Human	8.3	pEC50	=	8.3	Functional	GTPγs bindingGTPγs binding	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
	521	1404	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	5311068	1404	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	835	1404	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	CHEMBL778	1404	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	DB00633	1404	69	None	-20	5	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
	523	4106	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	5707	4106	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	CHEMBL297362	4106	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	DB11477	4106	93	None	-9	5	Human	7.5	pEC50	=	7.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	1960	2857	67	None	-12	18	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	439260	2857	67	None	-12	18	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	505	2857	67	None	-12	18	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL1437	2857	67	None	-12	18	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00368	2857	67	None	-12	18	Human	7.7	pEC50	=	7.7	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	1028	291	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	139148732	291	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	479	291	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	5816	291	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL679	291	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00668	291	71	None	-10	19	Human	8.0	pEC50	=	8	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	2683	3834	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	5487	3834	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	7308	3834	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	CHEMBL1079	3834	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	DB00697	3834	60	None	-1	6	Human	8.4	pEC50	=	8.4	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	12574	2605	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	4810	2605	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	CHEMBL19236	2605	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	DB09242	2605	88	None	1	8	Human	8.5	pEC50	=	8.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	2803	955	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	516	955	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	704	955	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	CHEMBL134	955	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	DB00575	955	58	None	-6	14	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	1343	1889	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3519	1889	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	522	1889	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	CHEMBL862	1889	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	DB01018	1889	62	None	-3	12	Human	9.0	pEC50	=	9	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	2435	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	395	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	520	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	5386	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	CHEMBL844	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	DB00484	722	100	None	7	10	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	3952	1888	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5353646	1888	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5443	1888	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5702063	1888	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL1331786	1888	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL420	1888	38	None	-1	21	Human	9.1	pEC50	=	9.1	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	521	1404	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	5311068	1404	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	835	1404	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	CHEMBL778	1404	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	DB00633	1404	69	None	-20	5	Human	9.5	pEC50	=	9.5	Functional	increased ERK1/2 phosphorylationincreased ERK1/2 phosphorylation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	523	4106	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	5707	4106	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	CHEMBL297362	4106	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	DB11477	4106	93	None	-9	5	Human	5.1	pEC50	=	5.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	1960	2857	67	None	-12	18	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	439260	2857	67	None	-12	18	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	505	2857	67	None	-12	18	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL1437	2857	67	None	-12	18	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00368	2857	67	None	-12	18	Human	5.3	pEC50	=	5.3	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	1028	291	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	139148732	291	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	479	291	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	5816	291	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL679	291	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00668	291	71	None	-10	19	Human	5.5	pEC50	=	5.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	12574	2605	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	4810	2605	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	CHEMBL19236	2605	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	DB09242	2605	88	None	1	8	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	2683	3834	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	5487	3834	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	7308	3834	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	CHEMBL1079	3834	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	DB00697	3834	60	None	-1	6	Human	5.8	pEC50	=	5.8	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	2803	955	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	516	955	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	704	955	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	CHEMBL134	955	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	DB00575	955	58	None	-6	14	Human	6.4	pEC50	=	6.4	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	1343	1889	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3519	1889	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	522	1889	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	CHEMBL862	1889	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	DB01018	1889	62	None	-3	12	Human	6.5	pEC50	=	6.5	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	2142	3096	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	4920903	3096	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	502	3096	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	5775	3096	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	CHEMBL597	3096	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	DB00692	3096	58	None	-11	18	Human	7.1	pEC50	=	7.1	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	36101495
	521	1404	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	5311068	1404	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	835	1404	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	CHEMBL778	1404	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	DB00633	1404	69	None	-20	5	Human	7.6	pEC50	=	7.6	Functional	increased cAMP generationincreased cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	2136	3095	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	4768	3095	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	7268	3095	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	CHEMBL753	3095	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	DB00925	3095	30	None	-2	21	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
	176	398	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	398	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	398	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	398	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	398	66	None	-1	40	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	1816	2540	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	4205	2540	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	7241	2540	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	CHEMBL654	2540	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	DB00370	2540	102	None	-39	12	Human	7.1	pIC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10636247
	3952	1888	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5353646	1888	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5443	1888	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5702063	1888	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL1331786	1888	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL420	1888	38	None	-1	21	Human	7.4	pIC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	1028	291	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	139148732	291	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	479	291	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	5816	291	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL679	291	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00668	291	71	None	-10	19	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
	523	4106	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	5707	4106	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	CHEMBL297362	4106	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	DB11477	4106	93	None	-9	5	Human	6.5	pIC50	=	6.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
	1960	2857	67	None	-12	18	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	439260	2857	67	None	-12	18	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	505	2857	67	None	-12	18	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	CHEMBL1437	2857	67	None	-12	18	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	DB00368	2857	67	None	-12	18	Human	6.6	pIC50	=	6.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
	12574	2605	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	4810	2605	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	CHEMBL19236	2605	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	DB09242	2605	88	None	1	8	Human	7.5	pIC50	=	7.5	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
	2683	3834	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	5487	3834	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	7308	3834	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	CHEMBL1079	3834	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	DB00697	3834	60	None	-1	6	Human	7.6	pIC50	=	7.6	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
	11079	2733	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	3369	2733	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	4436	2733	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	5509	2733	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	CHEMBL761	2733	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	DB06711	2733	63	None	-5	7	Human	7.8	pIC50	=	7.8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
	3952	1888	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5353646	1888	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5443	1888	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	5702063	1888	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL1331786	1888	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	CHEMBL420	1888	38	None	-1	21	Human	7.9	pIC50	=	7.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
	1343	1889	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3519	1889	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	522	1889	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	CHEMBL862	1889	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	DB01018	1889	62	None	-3	12	Human	8.0	pIC50	=	8	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
	3658	4107	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	517	4107	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	5709	4107	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	CHEMBL312448	4107	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	DB06694	4107	53	None	-1	18	Human	8.1	pIC50	=	8.1	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
	2803	955	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	516	955	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	704	955	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	CHEMBL134	955	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	DB00575	955	58	None	-6	14	Human	8.2	pIC50	=	8.2	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
	124	2981	47	None	-3	24	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	2032	2981	47	None	-3	24	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	4636	2981	47	None	-3	24	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	CHEMBL762	2981	47	None	-3	24	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	DB00935	2981	47	None	-3	24	Human	8.4	pIC50	=	8.4	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
	2435	722	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	395	722	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	520	722	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	5386	722	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	CHEMBL844	722	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	DB00484	722	100	None	7	10	Human	8.9	pIC50	=	8.9	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
	521	1404	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	5311068	1404	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	835	1404	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	CHEMBL778	1404	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
	DB00633	1404	69	None	-20	5	Human	9.3	pIC50	=	9.3	Functional	inhibition of forskolin stimulated cAMP generationinhibition of forskolin stimulated cAMP generation	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		1353	1911	93	None	-190	83	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-190	83	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-190	83	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-190	83	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-190	83	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		15387	45822	55	None	-1	24	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1531134	45822	55	None	-1	24	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		37	778	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	778	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	778	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	778	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	778	60	None	-3	17	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		5591	157531	90	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		CHEMBL408	157531	90	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		5022	1651	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		6918248	1651	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		8182	1651	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL231068	1651	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		DB04908	1651	76	None	-	9	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		176	398	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2157	398	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		2566	398	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		CHEMBL633	398	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		DB01118	398	66	None	-3	31	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
		3152	188411	103	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	188411	103	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		2335	11848	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-5	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		135	2532	43	None	-4	58	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-4	58	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-4	58	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-4	58	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-4	58	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		98941	46950	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL154126	46950	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		103	4153	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	-54	53	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		36811	1454	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		535	1454	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		937	1454	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL926	1454	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		DB00841	1454	37	None	-	7	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		5330286	67571	104	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		CHEMBL189963	67571	104	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		4908	188806	78	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		CHEMBL506	188806	78	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		1343	1889	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3519	1889	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		522	1889	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		CHEMBL862	1889	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		DB01018	1889	62	None	-11	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3351	95002	52	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
		CHEMBL254857	95002	52	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
		2389	3331	118	None	-77	67	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-77	67	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-77	67	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-77	67	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-77	67	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5360696	1406	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		6953	1406	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		842	1406	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		CHEMBL52440	1406	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		DB00514	1406	30	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		460612	206044	66	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		6918992	206044	66	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL852	206044	66	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		135398737	958	93	None	-26	89	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-26	89	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-26	89	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-26	89	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-26	89	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		21722	17992	31	None	-	6	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		CHEMBL126224	17992	31	None	-	6	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		5351322	94791	38	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL25336	94791	38	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		3584	3777	64	None	-251	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	3777	64	None	-251	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	3777	64	None	-251	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	3777	64	None	-251	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	3777	64	None	-251	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		129893322	28618	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		4923	28618	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353897	28618	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		6178111	28618	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1377	28618	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		237	204865	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL546257	204865	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL554190	204865	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL7568	204865	48	None	-1	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		2402	3370	62	None	-6	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	3370	62	None	-6	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	3370	62	None	-6	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	3370	62	None	-6	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	3370	62	None	-6	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		25295	13620	37	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1194287	13620	37	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		71698	203429	35	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	262	6	3	3	2.2	Cc1cc2c(OCC(O)CNC(C)C)cccc2[nH]1	10.1038/s41467-023-40064-9
		CHEMBL65717	203429	35	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	262	6	3	3	2.2	Cc1cc2c(OCC(O)CNC(C)C)cccc2[nH]1	10.1038/s41467-023-40064-9
		180	401	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-58	40	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		5584	203211	44	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL644	203211	44	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		1400	1957	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	1957	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	1957	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	1957	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	1957	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	1957	70	None	-	3	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		4151	3607	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		493	3607	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		5312125	3607	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL24778	3607	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		DB06207	3607	89	None	-	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		56959	31556	103	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
		CHEMBL1404	31556	103	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
		CHEMBL1526084	31556	103	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
		46780481	107531	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	107531	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	107531	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	107531	20	None	-47	53	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		1593	2340	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		30668	2340	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		9868	2340	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL17860	2340	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		DB04948	2340	66	None	5	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
		1153	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		12668023	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026874	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026875	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		3341	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		6603851	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		933	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		939	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		985	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1160786	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1161520	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL588	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		DB00800	1628	58	None	-	10	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		2683	3834	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		5487	3834	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		7308	3834	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		CHEMBL1079	3834	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		DB00697	3834	60	None	-3	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		1909	2822	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		2559	2822	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		4474	2822	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL1484	2822	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL3302409	2822	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		DB00622	2822	64	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		3053	205134	95	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		CHEMBL780	205134	95	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		242	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		9853053	120519	74	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		CHEMBL354541	120519	74	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		93154	5436	29	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL107360	5436	29	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		68602	205126	80	None	-1	7	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		CHEMBL77921	205126	80	None	-1	7	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		5625	199668	72	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	10.1038/s41467-023-40064-9
		CHEMBL593	199668	72	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	6	3	6	2.7	CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1	10.1038/s41467-023-40064-9
		208898	66199	78	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		CHEMBL184412	66199	78	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		3627	44129	18	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1515447	44129	18	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		2683	3834	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		5487	3834	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		7308	3834	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		CHEMBL1079	3834	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		DB00697	3834	60	None	-3	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
		3652	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		57	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		60809	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		CHEMBL21536	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		DB15357	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		3354	41784	50	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		CHEMBL1493	41784	50	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		319	1324	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	1324	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	1324	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	1324	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	1324	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	1324	44	None	-	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		1343	1889	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		3519	1889	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		522	1889	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		CHEMBL862	1889	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		DB01018	1889	62	None	-11	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
		102	4127	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	4127	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	4127	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	4127	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	4127	48	None	-5	49	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		242	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-26	51	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		2540	4401	111	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1014	4401	111	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
		1890	2759	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	2759	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	2759	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	2759	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	2759	49	None	-	16	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		1613	2348	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-8	44	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		9429	202133	58	None	-	5	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	202133	58	None	-	5	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		11057	176149	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3468	176149	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL459265	176149	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL64894	176149	23	None	-1	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3607	36382	72	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		CHEMBL144673	36382	72	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		16564	204995	32	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		CHEMBL76725	204995	32	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		21855	84246	42	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL22108	84246	42	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		5472	205818	75	None	-1	3	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1717	205818	75	None	-1	3	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
		CHEMBL833	205818	75	None	-1	3	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
		3152	188411	103	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	188411	103	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		10531	1420	21	None	-5	23	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-5	23	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-5	23	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-5	23	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-5	23	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		68617	205527	62	None	-3	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1709	205527	62	None	-3	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL809	205527	62	None	-3	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
		1935	3734	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		2551	3734	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		6687	3734	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL95	3734	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00382	3734	97	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		213046	2385	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	2385	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	2385	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	2385	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	2385	59	None	-19	9	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		5314	204108	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	9	0	4	0.3	C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL703	204108	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	9	0	4	0.3	C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		7019	167976	106	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1308088	167976	106	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43184	167976	106	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		2470	3653	50	None	-	59	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		3300	3653	50	None	-	59	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		5265	3653	50	None	-	59	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		99	3653	50	None	-	59	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL267930	3653	50	None	-	59	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
		25151352	140606	67	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	140606	67	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		68602	205126	80	None	-1	7	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		CHEMBL77921	205126	80	None	-1	7	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
		3634	84108	51	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL22077	84108	51	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		104903	56344	17	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1630578	56344	17	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		3294	2006	111	None	-47	45	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	2006	111	None	-47	45	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	2006	111	None	-47	45	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	2006	111	None	-47	45	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	2006	111	None	-47	45	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		3561	19077	39	None	-1	11	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1289	19077	39	None	-1	11	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		3157	1470	71	None	-61	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	1470	71	None	-61	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	1470	71	None	-61	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	1470	71	None	-61	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	1470	71	None	-61	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		448537	160250	89	None	-33	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	160250	89	None	-33	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		1547484	940	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	940	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	940	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	940	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	940	74	None	-5	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3047788	78196	15	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL2105148	78196	15	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		1212	1662	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		204	1662	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		3372	1662	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL726	1662	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00623	1662	50	None	-165	65	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		1224	1432	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	1432	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	1432	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	1432	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	1432	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	1432	83	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		135398737	958	93	None	-26	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-26	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-26	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-26	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-26	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		2585	803	103	None	-28	21	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	803	103	None	-28	21	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	803	103	None	-28	21	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	803	103	None	-28	21	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	803	103	None	-28	21	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		1574	2313	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		5359272	2313	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		7595	2313	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		CHEMBL592	2313	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		DB00854	2313	12	None	-	6	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	257	0	1	2	3.1	Oc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
		242	470	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-26	51	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		3678	94792	57	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL253371	94792	57	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		3002977	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		803	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		806	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201187	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL256907	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL584744	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		DB04835	2460	71	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	513	8	1	5	6.0	O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C	10.1038/s41467-023-40064-9
		441383	20333	57	None	-2	16	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1306	20333	57	None	-2	16	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		193962	103793	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		CHEMBL308954	103793	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		23497	22892	38	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	3	3	5	0.1	COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
		CHEMBL1328898	22892	38	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	3	3	5	0.1	COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
		11154555	800	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5037	800	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		7671	800	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL2028019	800	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL3085826	800	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB06016	800	62	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		2107	3055	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		4747	3055	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		9216	3055	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL251940	3055	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB01608	3055	50	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2580	78395	18	None	-	2	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL2110775	78395	18	None	-	2	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		2600	3779	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	-	13	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		1599	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3955	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7215	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL841	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00836	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3280	48449	28	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL1555736	48449	28	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		5440	28724	37	None	-	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	28724	37	None	-	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		72287	61061	38	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1764	61061	38	None	-	2	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		5210	33338	48	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		CHEMBL1200765	33338	48	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		CHEMBL1419	33338	48	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
		213046	2385	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	2385	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	2385	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	2385	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	2385	59	None	-19	9	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		3601	14503	9	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201349	14503	9	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		115368	3056	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2112	3056	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		7556	3056	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1472975	3056	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		DB08922	3056	47	None	-	4	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2148	3890	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		2150	3890	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		2784	3890	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		5610	3890	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		CHEMBL11608	3890	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		DB08841	3890	114	None	-	4	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1038/s41467-023-40064-9
		11079	2733	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		3369	2733	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		4436	2733	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		5509	2733	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL761	2733	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB06711	2733	63	None	-1	5	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		2162	41514	100	None	1	6	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1491	41514	100	None	1	6	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		2146	3100	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	3100	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	3100	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	3100	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	3100	67	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		11434515	261	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		11519741	261	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		4484	261	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		7449	261	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL1194325	261	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		DB08897	261	6	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		2520	204008	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	204008	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	204008	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		2337	3256	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-50	62	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		2520	204008	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	204008	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	204008	70	None	-6	12	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		1531	2266	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		3869	2266	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		7207	2266	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		CHEMBL429	2266	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		DB00598	2266	69	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-93	65	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		60663	175669	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1421212	175669	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1534525	175669	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL45816	175669	42	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		3598	187821	76	None	-2	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL496	187821	76	None	-2	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		228	445	28	None	-5	24	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		33	445	28	None	-5	24	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		6005	445	28	None	-5	24	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		CHEMBL53	445	28	None	-5	24	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		DB00714	445	28	None	-5	24	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		2406	100404	89	None	-16	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		CHEMBL290106	100404	89	None	-16	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		135412795	44751	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
		CHEMBL1521495	44751	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
		3166	169420	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL442444	169420	23	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		134	2514	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	2514	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	2514	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	2514	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	2514	24	None	-74	67	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		2028	2979	80	None	-	10	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		359	2979	80	None	-	10	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		4634	2979	80	None	-	10	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		CHEMBL1231	2979	80	None	-	10	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		DB01062	2979	80	None	-	10	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		124087	1389	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	1389	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	1389	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	1389	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	1389	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		2343	14454	57	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
		CHEMBL1201039	14454	57	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
		82146	4530	113	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		CHEMBL1023	4530	113	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		1027	1576	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3241	1576	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		7176	1576	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL1106	1576	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB00751	1576	73	None	-	2	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		2200	20203	61	None	-	2	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1256819	20203	61	None	-	2	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1305	20203	61	None	-	2	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		3675	7734	68	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1089	7734	68	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
		1712	2492	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4078	2492	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		7227	2492	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		CHEMBL1088	2492	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		DB00933	2492	43	None	-	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		1753	2504	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		483	2504	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		6082	2504	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		CHEMBL524	2504	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		DB00723	2504	28	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
		3157	1470	71	None	-61	10	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	1470	71	None	-61	10	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	1470	71	None	-61	10	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	1470	71	None	-61	10	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	1470	71	None	-61	10	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		2473	163183	47	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
		CHEMBL418134	163183	47	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
		2805	161890	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL415087	161890	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2303	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		4946	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		564	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		63	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		91536	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		CHEMBL27	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		CHEMBL452861	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		DB00571	3187	68	None	-	26	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
		2966	59149	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	175	0	2	1	0.9	N=C(N)N1CCc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL1593558	59149	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	175	0	2	1	0.9	N=C(N)N1CCc2ccccc2C1	10.1038/s41467-023-40064-9
		CHEMBL169901	59149	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	175	0	2	1	0.9	N=C(N)N1CCc2ccccc2C1	10.1038/s41467-023-40064-9
		2286	3183	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-13	30	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL5291995	194536	0	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		4418	34222	85	None	-	6	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		CHEMBL142635	34222	85	None	-	6	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		3584	3777	64	None	-251	13	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	3777	64	None	-251	13	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	3777	64	None	-251	13	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	3777	64	None	-251	13	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	3777	64	None	-251	13	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		2200	20203	61	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1256819	20203	61	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1305	20203	61	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		180	401	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-58	40	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL4743867	214033	14	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		6237	86804	46	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		CHEMBL232201	86804	46	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		1588	2325	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		28864	2325	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		43	2325	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL157138	2325	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB00589	2325	27	None	1	44	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		10531	1420	21	None	-5	23	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-5	23	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-5	23	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-5	23	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-5	23	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		102	4127	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	4127	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	4127	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	4127	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	4127	48	None	-5	49	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3658	4107	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		517	4107	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		5709	4107	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL312448	4107	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		DB06694	4107	53	None	-5	8	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		119584	2595	102	None	-2	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		1848	2595	102	None	-2	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		242	2595	102	None	-2	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		CHEMBL60889	2595	102	None	-2	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		DB11675	2595	102	None	-2	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	10.1038/s41467-023-40064-9
		2803	955	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		516	955	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		704	955	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		CHEMBL134	955	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		DB00575	955	58	None	-1	19	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		2342	599	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		331	599	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		7124	599	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		CHEMBL1201250	599	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		DB00767	599	39	None	-1	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
		2762	3863	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	3863	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	3863	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	3863	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	3863	31	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		135	2532	43	None	-4	58	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-4	58	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-4	58	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-4	58	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-4	58	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		2710	84308	31	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL22150	84308	31	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		62867	3129	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		7557	3129	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL398880	3129	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01621	3129	35	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2865	4143	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-64	53	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		2726	919	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-87	72	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		214	3860	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	3860	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	3860	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	3860	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	3860	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	3860	58	None	-75	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		12488	1657	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		941361	1657	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		CHEMBL30008	1657	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		DB04841	1657	56	None	-6	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		2389	3331	118	None	-77	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-77	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-77	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-77	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-77	67	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		16351	102730	47	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	102730	47	None	-	6	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		6726	1280	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7151	1280	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		749	1280	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL648	1280	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB01176	1280	51	None	-10	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		68712	100338	60	None	-1	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
		CHEMBL289480	100338	60	None	-1	5	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
		3950	189508	109	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL514	189508	109	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL3039583	210949	0	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		121515	199099	63	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL588934	199099	63	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		2398	954	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	954	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	954	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	954	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	954	62	None	-14	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		3033538	1319	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		7155	1319	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		781	1319	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1201216	1319	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		DB00298	1319	39	None	-	9	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL508338	188966	0	None	-6	6	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		65863	14465	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1201196	14465	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-93	65	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		1816	2540	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		4205	2540	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		7241	2540	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		CHEMBL654	2540	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		DB00370	2540	102	None	-51	18	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
		1548955	88581	20	None	-1	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2800	88581	20	None	-1	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2355051	88581	20	None	-1	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		3547	141373	71	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL38380	141373	71	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		CHEMBL541388	141373	71	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
		4735	195115	96	None	-9	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL361506	195115	96	None	-9	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL55	195115	96	None	-9	10	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		12555	17961	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL12610	17961	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		6077	150698	31	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	150698	31	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		4822	45032	47	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL152408	45032	47	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		34040	28085	72	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		CHEMBL1372950	28085	72	None	-	1	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		4098	32505	30	None	-13	11	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1255739	32505	30	None	-13	11	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1411979	32505	30	None	-13	11	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		16362	3125	71	None	-501	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-501	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-501	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-501	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-501	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		9822750	78409	65	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL2111097	78409	65	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		2142	3096	58	None	-2	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4920903	3096	58	None	-2	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		502	3096	58	None	-2	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		5775	3096	58	None	-2	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL597	3096	58	None	-2	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		DB00692	3096	58	None	-2	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		3783	14005	23	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL1197051	14005	23	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		7029	13669	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	5	0	2	2.6	CCN(CC)C(C)C(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1194666	13669	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	5	0	2	2.6	CCN(CC)C(C)C(=O)c1ccccc1	10.1038/s41467-023-40064-9
		71897	78248	19	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		CHEMBL2106537	78248	19	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		2142	3096	58	None	-2	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4920903	3096	58	None	-2	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		502	3096	58	None	-2	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		5775	3096	58	None	-2	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL597	3096	58	None	-2	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		DB00692	3096	58	None	-2	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
		4209	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		2993	114692	24	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL121663	114692	24	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL333826	114692	24	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		2803	955	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		516	955	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		704	955	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		CHEMBL134	955	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		DB00575	955	58	None	-1	19	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
		2389	3331	118	None	-77	67	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-77	67	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-77	67	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-77	67	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-77	67	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		4167	14500	43	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	14500	43	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		4034	55822	55	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	55822	55	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		60860	205639	30	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL1615777	205639	30	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL818	205639	30	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		2446	154653	57	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL399510	154653	57	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		277	1301	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2913	1301	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		765	1301	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL516	1301	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB00434	1301	62	None	-33	50	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2284	3182	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	3182	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	3182	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	3182	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	3182	33	None	-12	29	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		3658	4107	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		517	4107	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		5709	4107	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL312448	4107	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		DB06694	4107	53	None	-5	8	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
		1960	2857	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		439260	2857	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		505	2857	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		CHEMBL1437	2857	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		DB00368	2857	67	None	-23	26	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		102	4127	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	4127	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	4127	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	4127	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	4127	48	None	-5	49	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		68802	110035	37	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		CHEMBL32350	110035	37	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		4209	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-3235	33	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		3158	56267	27	None	-3467	20	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-3467	20	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		11976	920	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	920	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	920	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	920	59	None	-	24	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		681	1465	72	None	-	39	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		940	1465	72	None	-	39	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		947	1465	72	None	-	39	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL59	1465	72	None	-	39	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		DB00988	1465	72	None	-	39	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		31101	729	40	None	-10	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	729	40	None	-10	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	729	40	None	-10	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	729	40	None	-10	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	729	40	None	-10	36	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		22530	56130	58	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1600878	56130	58	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1625607	56130	58	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		2510	3260	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		3034034	3260	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		4523	3260	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		CHEMBL170	3260	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		DB00468	3260	75	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O	10.1038/s41467-023-40064-9
		2181	3128	46	None	-58	35	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		4830	3128	46	None	-58	35	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		92	3128	46	None	-58	35	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL440294	3128	46	None	-58	35	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		DB09286	3128	46	None	-58	35	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		2391	207453	92	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	361	5	0	5	4.1	CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1	10.1038/s41467-023-40064-9
		CHEMBL942	207453	92	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	361	5	0	5	4.1	CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1	10.1038/s41467-023-40064-9
		2337	3256	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-50	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		22323	15299	32	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9571037	15299	32	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1213553	15299	32	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		10180	98869	47	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL279014	98869	47	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		2220	3134	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		27400	3134	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		93	3134	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL294951	3134	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB06153	3134	82	None	-	14	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		1712095	195392	30	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL551978	195392	30	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		3336	95001	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1405922	95001	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL254832	95001	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3158	56267	27	None	-3467	20	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-3467	20	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		5489013	57405	32	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		CHEMBL1651913	57405	32	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		2105	3054	37	None	-58	33	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	3054	37	None	-58	33	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	3054	37	None	-58	33	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	3054	37	None	-58	33	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	3054	37	None	-58	33	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		3294	2006	111	None	-47	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	2006	111	None	-47	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	2006	111	None	-47	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	2006	111	None	-47	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	2006	111	None	-47	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		5328940	100216	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	100216	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		2683	102888	25	None	-12	16	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL305906	102888	25	None	-12	16	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL334255	102888	25	None	-12	16	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		4151	3607	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		493	3607	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		5312125	3607	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL24778	3607	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		DB06207	3607	89	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		2247	505	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-58	42	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2351	3286	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		2820	3286	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		5035	3286	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		CHEMBL81	3286	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		DB00481	3286	64	None	-9	21	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
		2146	3100	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	3100	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	3100	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	3100	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	3100	67	None	-	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		443869	78141	45	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2103761	78141	45	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		2605	3783	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		36920	3783	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		571	3783	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL434200	3783	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		DB13775	3783	30	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	2	4	2.9	OC(COc1cccc2c1SCCC2)CNC(C)(C)C	10.1038/s41467-023-40064-9
		5419	18060	57	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL1200413	18060	57	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
		CHEMBL1266	18060	57	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
		8249	59405	65	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1528839	59405	65	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL170988	59405	65	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
		191	403	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	403	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	403	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	403	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	403	98	None	-41	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2286	3183	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-13	30	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5354	155656	21	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL404849	155656	21	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		1086	1590	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		3290	1590	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		7181	1590	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		CHEMBL1206	1590	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		DB00392	1590	27	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		4829	199956	108	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	1	5	3.2	CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1	10.1038/s41467-023-40064-9
		CHEMBL595	199956	108	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	1	5	3.2	CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1	10.1038/s41467-023-40064-9
		1227	2489	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2331	2489	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		3957	2489	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		4992	2489	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL511	2489	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		DB06691	2489	43	None	-91	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		37	778	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	778	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	778	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	778	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	778	60	None	-3	17	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		3584	3777	64	None	-251	13	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	3777	64	None	-251	13	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	3777	64	None	-251	13	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	3777	64	None	-251	13	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	3777	64	None	-251	13	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7099	195522	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		CHEMBL55400	195522	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		1782	2518	84	None	-5	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		241	2518	84	None	-5	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		4168	2518	84	None	-5	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		CHEMBL86	2518	84	None	-5	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		DB01233	2518	84	None	-5	22	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
		5311507	194815	41	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL53904	194815	41	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		26987	949	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	-158	21	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		3103	41658	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1492	41658	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		31101	729	40	None	-10	36	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	729	40	None	-10	36	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	729	40	None	-10	36	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	729	40	None	-10	36	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	729	40	None	-10	36	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		135	2532	43	None	-4	58	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-4	58	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-4	58	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-4	58	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-4	58	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		40	1547	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		77993	1547	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		995	1547	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1510	1547	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		DB00216	1547	58	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		1577	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2537	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5355	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5501	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		643497	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		688272	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		958	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		960	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL196677	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL26	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL267044	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB00391	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB16021	3703	110	None	-3	21	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		212	3806	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-6	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		5328940	100216	107	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	100216	107	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		54477	84653	36	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
		CHEMBL22242	84653	36	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
		5353853	17986	47	None	-16	15	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9556529	17986	47	None	-16	15	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1262	17986	47	None	-16	15	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		43082	60283	37	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1742452	60283	37	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		129211	3749	78	None	-120	15	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		2562	3749	78	None	-120	15	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		488	3749	78	None	-120	15	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		CHEMBL836	3749	78	None	-120	15	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		DB00706	3749	78	None	-120	15	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
		3952	1888	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5353646	1888	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5443	1888	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5702063	1888	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL1331786	1888	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL420	1888	38	None	-3	12	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		11079	2733	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		3369	2733	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		4436	2733	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		5509	2733	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL761	2733	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		DB06711	2733	63	None	-1	5	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
		3344	198318	57	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		CHEMBL576127	198318	57	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		6075	150108	42	None	-11	16	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL395110	150108	42	None	-11	16	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		73417116	154431	0	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL3989843	154431	0	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1038/s41467-023-40064-9
		65772	60403	8	None	-	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL174984	60403	8	None	-	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		4209	3163	75	None	-3235	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-3235	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-3235	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-3235	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-3235	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-3235	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		2444	14478	26	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201245	14478	26	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		213	3853	55	None	-10	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2717	3853	55	None	-10	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		5533	3853	55	None	-10	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL621	3853	55	None	-10	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00656	3853	55	None	-10	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		27901	78207	22	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2105458	78207	22	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		114948	60297	14	None	-	3	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		CHEMBL1743263	60297	14	None	-	3	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		1353	1911	93	None	-190	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-190	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-190	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-190	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-190	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		1028	291	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		139148732	291	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		479	291	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		5816	291	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		CHEMBL679	291	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		DB00668	291	71	None	-48	30	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
		9887712	167468	104	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	6	4	6	1.8	CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL429910	167468	104	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	408	6	4	6	1.8	CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1	10.1038/s41467-023-40064-9
		133	2496	52	None	-23	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		1723	2496	52	None	-23	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		28693	2496	52	None	-23	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL19215	2496	52	None	-23	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		DB13520	2496	52	None	-23	42	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		54758501	139067	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		CHEMBL3786343	139067	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		2146	3100	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	3100	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	3100	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	3100	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	3100	67	None	-	9	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		2865	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		1613	2348	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-8	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		68818	78268	28	None	-	0	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	217	1	2	3	2.2	c1ccc2c(SC3=NCCN3)c[nH]c2c1	10.1038/s41467-023-40064-9
		CHEMBL2107015	78268	28	None	-	0	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	217	1	2	3	2.2	c1ccc2c(SC3=NCCN3)c[nH]c2c1	10.1038/s41467-023-40064-9
		10219	188796	37	None	-1	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL493439	188796	37	None	-1	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL50588	188796	37	None	-1	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		2865	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-64	53	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		2749	344	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5574	344	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7237	344	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL829	344	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01246	344	40	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		5568	197500	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		66069	197500	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL1201102	197500	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL570	197500	29	None	-	5	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		4567	9948	34	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL114655	9948	34	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		9419	35922	35	None	-	6	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1442422	35922	35	None	-	6	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		1224	1432	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	1432	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	1432	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	1432	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	1432	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	1432	83	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		1830	2590	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		207	2590	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		23897	2590	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL460	2590	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		DB01618	2590	44	None	-14	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		9417	133512	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	133512	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	133512	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		37464	19221	26	None	-	4	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1290	19221	26	None	-	4	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		4601	206747	35	None	-2	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201023	206747	35	None	-2	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL900	206747	35	None	-2	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		104870	98880	47	None	-2	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		5374	98880	47	None	-2	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		CHEMBL279085	98880	47	None	-2	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
		5205	78187	58	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL2104895	78187	58	None	-	0	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		168295528	193031	0	None	-11	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-11	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-11	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168294767	193019	0	None	-11	20	Human	5.3	pEC50	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-11	20	Human	5.3	pEC50	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-11	20	Human	5.3	pEC50	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		102	4127	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		3659	4127	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		8969	4127	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		CHEMBL15245	4127	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		DB01392	4127	48	None	-5	49	Human	8.1	pEC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/np058114h
		168290235	192968	0	None	-40	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-40	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-40	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		164612037	185377	0	None	-11	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	185377	0	None	-11	20	Human	6.1	pEC50	=	6.1	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		44377036	120156	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL351483	120156	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376984	56223	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	485	3	0	5	4.0	Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162682	56223	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	485	3	0	5	4.0	Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376923	56427	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL163190	56427	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		22120332	56045	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	389	4	0	6	3.4	COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12	10.1016/s0960-894x(99)00591-0
		CHEMBL162490	56045	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	389	4	0	6	3.4	COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12	10.1016/s0960-894x(99)00591-0
		1588	2325	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	1	44	Human	9.5	pIC50	=	9.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		44376954	55740	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	387	3	0	5	4.0	Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		CHEMBL162232	55740	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	387	3	0	5	4.0	Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		22120322	55921	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1	10.1016/s0960-894x(99)00591-0
		CHEMBL162370	55921	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1	10.1016/s0960-894x(99)00591-0
		44377200	57420	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	437	3	0	5	4.1	Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165350	57420	1	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	437	3	0	5	4.1	Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		3294	2006	111	None	-	45	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		71360	2006	111	None	-	45	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		87	2006	111	None	-	45	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		CHEMBL14376	2006	111	None	-	45	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		DB04946	2006	111	None	-	45	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		44376958	57479	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		CHEMBL165796	57479	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1	10.1016/s0960-894x(99)00591-0
		3682	189437	12	None	-	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human adrenergic alpha2 receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2 receptor by radioligand displacement assay	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.bmc.2013.03.016
		CHEMBL1256784	189437	12	None	-	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human adrenergic alpha2 receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2 receptor by radioligand displacement assay	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.bmc.2013.03.016
		CHEMBL513389	189437	12	None	-	8	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human adrenergic alpha2 receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2 receptor by radioligand displacement assay	ChEMBL	277	6	2	3	2.6	Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2	10.1016/j.bmc.2013.03.016
		3045401	56059	32	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	359	3	0	5	3.4	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162501	56059	32	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	359	3	0	5	3.4	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376993	56484	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	427	3	0	5	4.7	Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL163247	56484	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	427	3	0	5	4.7	Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44377035	120130	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL351200	120130	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	3	0	5	3.7	Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44376900	56268	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	1	6	3.1	Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162826	56268	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	1	6	3.1	Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		44377007	57148	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL164612	57148	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1	10.1016/s0960-894x(99)00591-0
		10531	1420	21	None	-5	23	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	1420	21	None	-5	23	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	1420	21	None	-5	23	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	1420	21	None	-5	23	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	1420	21	None	-5	23	Human	9.0	pIC50	=	9.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		44376927	55637	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	461	3	0	5	5.0	Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL162147	55637	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	461	3	0	5	5.0	Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		9951544	57376	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	0	5	3.8	Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165181	57376	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	375	3	0	5	3.8	Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		107715	200945	22	None	-6	19	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	200945	22	None	-6	19	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	200945	22	None	-6	19	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		44376936	57474	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	4	0	5	3.7	Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165776	57474	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	373	4	0	5	3.7	Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1	10.1016/s0960-894x(99)00591-0
		10095594	12368	0	None	-	0	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1185501	12368	0	None	-	0	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL417550	12368	0	None	-	0	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10342423	99469	0	None	-	1	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	426	11	1	5	3.9	CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL28312	99469	0	None	-	1	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	426	11	1	5	3.9	CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL48925	99469	0	None	-	1	Bovine	7.0	pIC50	=	7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	426	11	1	5	3.9	CCCN(CCCCNC(=O)c1ccccc1OC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		44401591	68897	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	8	3	7	5.1	Nc1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL192266	68897	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	8	3	7	5.1	Nc1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		1220	187	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		31	187	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		7	187	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		CHEMBL56	187	55	None	-	44	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm00038a007
		10070029	165417	0	None	-	1	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL423841	165417	0	None	-	1	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54089	165417	0	None	-	1	Bovine	6.0	pIC50	=	6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		59271992	118048	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of alpha-adrenoceptor 2A (unknown origin)Inhibition of alpha-adrenoceptor 2A (unknown origin)	ChEMBL	513	13	2	7	3.5	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccccc2)C(C)C)ccc1OC	10.1016/j.bmcl.2015.02.040
		CHEMBL3403995	118048	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of alpha-adrenoceptor 2A (unknown origin)Inhibition of alpha-adrenoceptor 2A (unknown origin)	ChEMBL	513	13	2	7	3.5	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc2ccccc2)C(C)C)ccc1OC	10.1016/j.bmcl.2015.02.040
		2477	745	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		36	745	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		437	745	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL49	745	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		DB00490	745	59	None	-	29	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		121852	10166	7	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	10166	7	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	10166	7	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9981024	96097	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	96097	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	96097	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10040815	97060	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	306	7	1	4	1.8	CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL264027	97060	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	306	7	1	4	1.8	CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26715	97060	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	306	7	1	4	1.8	CCCN(CCNC(C)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10047322	97140	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL26783	97140	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL50993	97140	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		10364722	99085	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	99085	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	99085	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10338595	162499	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL416747	162499	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10265863	193324	0	None	-	0	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		CHEMBL52438	193324	0	None	-	0	Bovine	5.0	pIC50	=	5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		14450375	164870	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	233	0	1	3	2.3	Cc1ccc(O)c2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		CHEMBL422024	164870	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	233	0	1	3	2.3	Cc1ccc(O)c2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		1305	511	14	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		9934033	511	14	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL182150	511	14	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
		2585	803	103	None	-28	21	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	803	103	None	-28	21	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	803	103	None	-28	21	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	803	103	None	-28	21	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	803	103	None	-28	21	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		25208878	181063	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	406	6	1	3	4.9	CC1=C(CCN(C)C)c2cc(S(=O)(=O)Nc3cccc4ccccc34)ccc2C1	10.1021/jm8009469
		CHEMBL475969	181063	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	406	6	1	3	4.9	CC1=C(CCN(C)C)c2cc(S(=O)(=O)Nc3cccc4ccccc34)ccc2C1	10.1021/jm8009469
		44390778	64279	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	403	5	2	5	4.2	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		CHEMBL180962	64279	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	403	5	2	5	4.2	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		11284878	70441	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL194602	70441	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		9885114	119604	5	None	-95	12	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		CHEMBL346389	119604	5	None	-95	12	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		CHEMBL5070958	214249	3	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		4098	32505	30	None	-13	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	-13	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	-13	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		2812	4779	101	None	-32	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-32	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		16718919	199781	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	462	4	1	6	4.5	CC1=C(C2CCCN(C)C2)c2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1	10.1016/j.bmc.2009.08.006
		CHEMBL593889	199781	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	462	4	1	6	4.5	CC1=C(C2CCCN(C)C2)c2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1	10.1016/j.bmc.2009.08.006
		3561	19077	39	None	-1	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	19077	39	None	-1	11	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		23027211	197250	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL568400	197250	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		11284878	64343	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(N[C@H]2CC[C@@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181217	64343	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(N[C@H]2CC[C@@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44390713	123695	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL362193	123695	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44401626	71354	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	558	7	2	6	5.2	O=S(=O)(NCC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL195810	71354	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	558	7	2	6	5.2	O=S(=O)(NCC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL5076569	214449	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2cccnc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		191	403	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-41	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		100	3805	58	None	-33	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-33	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-33	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-33	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-33	55	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		3158	56267	27	None	-3467	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-3467	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		1343	1889	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		3519	1889	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		522	1889	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL862	1889	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		DB01018	1889	62	None	-11	9	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		4735	195115	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	195115	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	195115	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		3584	3777	64	None	-251	13	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		5401	3777	64	None	-251	13	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		7302	3777	64	None	-251	13	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		CHEMBL611	3777	64	None	-251	13	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		DB01162	3777	64	None	-251	13	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		44401552	165906	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	572	8	2	6	5.5	O=S(=O)(NCC1CCC(CNc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL425012	165906	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	572	8	2	6	5.5	O=S(=O)(NCC1CCC(CNc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		448537	160250	89	None	-33	25	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	160250	89	None	-33	25	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		2398	954	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-14	29	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		15730	71118	80	None	-2	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	71118	80	None	-2	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		6075	150108	42	None	-11	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	-11	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		31101	729	40	None	-10	36	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	729	40	None	-10	36	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	729	40	None	-10	36	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	729	40	None	-10	36	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	729	40	None	-10	36	Human	7.8	pIC50	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		44390730	64317	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	414	5	2	6	3.7	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C#N)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181099	64317	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	414	5	2	6	3.7	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C#N)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44390742	123290	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL361442	123290	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	407	5	2	5	4.0	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14450355	119968	0	None	-	0	Bovine	6.8	pIC50	=	6.8	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	259	3	0	3	3.0	CCCN1CCC=C2c3c(OC)cccc3OCC21	10.1021/jm00123a039
		CHEMBL349824	119968	0	None	-	0	Bovine	6.8	pIC50	=	6.8	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	259	3	0	3	3.0	CCCN1CCC=C2c3c(OC)cccc3OCC21	10.1021/jm00123a039
		6726	1280	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	-10	13	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		150	2509	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	2509	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	2509	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	2509	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	2509	21	None	-45	16	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		23027411	198520	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577912	198520	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		134	2514	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	2514	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	2514	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	2514	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	2514	24	None	-74	67	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		44190762	176880	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from adrenergic alpha2A receptorDisplacement of radioligand from adrenergic alpha2A receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		CHEMBL461571	176880	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from adrenergic alpha2A receptorDisplacement of radioligand from adrenergic alpha2A receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		2750	204061	76	None	-3	12	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	204061	76	None	-3	12	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		2351	3286	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	3286	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	3286	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	3286	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	3286	64	None	-9	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		1042	1581	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	1581	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	1581	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	1581	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	1581	23	None	-97	17	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		2274	3173	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-10	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44390733	62494	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	537	7	2	6	5.9	CN(C)c1nc(NC2CCC(NCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL178084	62494	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	537	7	2	6	5.9	CN(C)c1nc(NC2CCC(NCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		11342160	122935	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360671	122935	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		11342160	122935	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL360671	122935	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	573	6	1	7	4.6	CN(C)c1nc(NC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		23027035	198547	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		CHEMBL578170	198547	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
		240	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		2769	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		44279790	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		660	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL1729	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL560739	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		DB00604	944	43	None	-12	24	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		26757	207978	31	None	-1	2	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		CHEMBL972	207978	31	None	-1	2	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		196129	67798	17	None	-85	15	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	67798	17	None	-85	15	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		4011	82408	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		26987	949	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	-158	21	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		28417	40039	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	40039	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		16215415	187332	1	None	3	5	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		CHEMBL493091	187332	1	None	3	5	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		10331436	324	10	None	-	6	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		160	324	10	None	-	6	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		CHEMBL133455	324	10	None	-	6	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
		45482789	198925	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		CHEMBL584554	198925	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		1016	3747	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-12	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		3823	50221	42	None	-40	10	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	50221	42	None	-40	10	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	50221	42	None	-40	10	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		2803	955	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		516	955	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		704	955	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		CHEMBL134	955	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		DB00575	955	58	None	-	19	Bovine	8.7	pIC50	=	8.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm00123a039
		1043	1582	14	None	-8	28	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	1582	14	None	-8	28	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	1582	14	None	-8	28	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	1582	14	None	-8	28	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	1582	14	None	-8	28	Human	8.7	pIC50	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		44376975	55986	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	435	5	0	5	4.6	O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12	10.1016/s0960-894x(99)00591-0
		CHEMBL162436	55986	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	435	5	0	5	4.6	O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12	10.1016/s0960-894x(99)00591-0
		121852	10166	7	None	-	1	Bovine	7.7	pIC50	=	7.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	10166	7	None	-	1	Bovine	7.7	pIC50	=	7.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	10166	7	None	-	1	Bovine	7.7	pIC50	=	7.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		135	2532	43	None	-4	58	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		1796	2532	43	None	-4	58	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		4184	2532	43	None	-4	58	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		CHEMBL6437	2532	43	None	-4	58	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		DB06148	2532	43	None	-4	58	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
		45485061	198754	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	489	5	2	5	5.0	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL583014	198754	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	489	5	2	5	5.0	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
		44390787	122565	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	443	5	2	5	4.3	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)c(F)c3F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360159	122565	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	443	5	2	5	4.3	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)c(F)c3F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		9981024	96097	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	96097	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	96097	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		131001	98993	7	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27995	98993	7	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		10321248	99426	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL28287	99426	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50722	99426	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10251673	99490	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283207	99490	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52396	99490	0	None	-	1	Bovine	5.7	pIC50	=	5.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9978353	11253	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL1178987	11253	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL52785	11253	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		10105405	96032	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	5	0	2	3.1	CCCN(CCC)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL25984	96032	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	5	0	2	3.1	CCCN(CCC)C1COc2ccccc2C1	10.1021/jm00038a007
		11743327	98702	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27763	98702	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		1577	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		2537	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5355	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5501	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		643497	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		688272	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		958	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		960	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL196677	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL26	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL267044	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB00391	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB16021	3703	110	None	-3	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		657255	199084	34	None	-10	15	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	199084	34	None	-10	15	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		1210	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	918	51	None	-416	21	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		5467	205928	43	None	-6	5	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		CHEMBL84158	205928	43	None	-6	5	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		14151683	56537	0	None	-	0	Bovine	6.7	pIC50	=	6.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	2	0	2	2.9	CCCN1CCC=C2c3ccccc3OCC21	10.1021/jm00123a039
		CHEMBL163803	56537	0	None	-	0	Bovine	6.7	pIC50	=	6.7	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	229	2	0	2	2.9	CCCN1CCC=C2c3ccccc3OCC21	10.1021/jm00123a039
		44401616	70033	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NCC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL193970	70033	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	601	8	2	7	5.3	CN(C)c1nc(NCC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		45484995	198519	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL577904	198519	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		5897	105211	80	None	-7	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		CHEMBL311469	105211	80	None	-7	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		1212	1662	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-165	65	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		4601	206747	35	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		1530	2182	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-70	21	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		237	204865	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	204865	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	204865	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	204865	48	None	-1	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		124	2981	47	None	-4	33	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2032	2981	47	None	-4	33	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		4636	2981	47	None	-4	33	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL762	2981	47	None	-4	33	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		DB00935	2981	47	None	-4	33	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL5083458	214863	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		c1cnc2c(c1)CN[C@@H](CN(CCCCNC1COC1)[C@H]1CCCc3cccnc31)C2	10.1021/acs.jmedchem.1c01564
		25014630	83539	1	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		CHEMBL2203713	83539	1	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		2683	102888	25	None	-12	16	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	102888	25	None	-12	16	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	102888	25	None	-12	16	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		14151624	55805	0	None	-	0	Bovine	6.6	pIC50	=	6.6	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3ccc(O)cc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162282	55805	0	None	-	0	Bovine	6.6	pIC50	=	6.6	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3ccc(O)cc3OC[C@H]21	10.1021/jm00123a039
		2337	3256	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-50	62	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		1305	511	14	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2005.05.121
		9934033	511	14	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2005.05.121
		CHEMBL182150	511	14	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2005.05.121
		4209	3163	75	None	-3235	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		4893	3163	75	None	-3235	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		503	3163	75	None	-3235	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		5385	3163	75	None	-3235	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL2	3163	75	None	-3235	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		DB00457	3163	75	None	-3235	33	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		2105	3054	37	None	-58	33	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	3054	37	None	-58	33	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	3054	37	None	-58	33	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	3054	37	None	-58	33	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	3054	37	None	-58	33	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		1782	2518	84	None	-5	22	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		241	2518	84	None	-5	22	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		4168	2518	84	None	-5	22	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		CHEMBL86	2518	84	None	-5	22	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		DB01233	2518	84	None	-5	22	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		3151	1462	97	None	-99	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	1462	97	None	-99	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	1462	97	None	-99	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	1462	97	None	-99	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	1462	97	None	-99	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		2803	955	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		516	955	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		704	955	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		CHEMBL134	955	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		DB00575	955	58	None	-1	19	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		42	2063	57	None	-	18	Bovine	5.6	pIC50	=	5.6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		56971	2063	57	None	-	18	Bovine	5.6	pIC50	=	5.6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL8412	2063	57	None	-	18	Bovine	5.6	pIC50	=	5.6	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL5077132	214484	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		CN(CCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21)C1CCOCC1	10.1021/acs.jmedchem.1c01564
		277	1301	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-33	50	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		24180125	95656	71	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		CHEMBL257991	95656	71	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		68617	205527	62	None	-3	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	205527	62	None	-3	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	205527	62	None	-3	26	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		3168	9262	92	None	-123	21	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-123	21	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		1227	2489	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	2489	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	2489	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	2489	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	2489	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	2489	43	None	-91	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2435	722	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		395	722	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		520	722	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		5386	722	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		CHEMBL844	722	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		DB00484	722	100	None	-2	12	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		44376845	55545	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	419	5	0	7	3.4	COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC	10.1016/s0960-894x(99)00591-0
		CHEMBL162058	55545	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	419	5	0	7	3.4	COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC	10.1016/s0960-894x(99)00591-0
		102	4127	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		3659	4127	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		8969	4127	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		CHEMBL15245	4127	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		DB01392	4127	48	None	-5	49	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm900458r
		44377006	57463	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1	10.1016/s0960-894x(99)00591-0
		CHEMBL165677	57463	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	393	3	0	5	4.0	Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1	10.1016/s0960-894x(99)00591-0
		10014217	99748	0	None	-	1	Bovine	5.5	pIC50	=	5.5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	2	0	3	2.1	COc1cccc2c1CC(N1CCCC1)CO2	10.1021/jm00038a007
		CHEMBL285010	99748	0	None	-	1	Bovine	5.5	pIC50	=	5.5	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	233	2	0	3	2.1	COc1cccc2c1CC(N1CCCC1)CO2	10.1021/jm00038a007
		10019102	32520	3	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	323	3	0	3	3.7	COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1	10.1021/jm010992z
		CHEMBL141209	32520	3	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	323	3	0	3	3.7	COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1	10.1021/jm010992z
		44390385	122516	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	9	2	6	6.4	CN(C)c1nc(NCC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360117	122516	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	9	2	6	6.4	CN(C)c1nc(NCC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		15987265	196887	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL566075	196887	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		10915140	29474	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	351	5	0	3	4.2	COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1	10.1021/jm010992z
		CHEMBL138458	29474	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	351	5	0	3	4.2	COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1	10.1021/jm010992z
		2335	11848	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	11848	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	11848	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	11848	22	None	-5	12	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		176	398	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-3	31	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		44596863	198927	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	367	6	1	6	2.3	C=Cc1c(C)nn(CCCN2CCN(c3ccc(C)cc3)CC2)c(=O)c1N	10.1021/jm900458r
		CHEMBL584606	198927	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 minsDisplacement of [3H]MK9112 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells after 60 mins	ChEMBL	367	6	1	6	2.3	C=Cc1c(C)nn(CCCN2CCN(c3ccc(C)cc3)CC2)c(=O)c1N	10.1021/jm900458r
		2284	3182	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-12	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		44390369	64610	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	629	9	1	7	5.9	CN(C)c1nc(NCC2CCC(CN(C)S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181727	64610	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	629	9	1	7	5.9	CN(C)c1nc(NCC2CCC(CN(C)S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		3038525	13549	114	None	-2	3	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		CHEMBL119385	13549	114	None	-2	3	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		44240743	6757	15	None	-	1	Human	4.5	pIC50	=	4.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	370	7	2	3	4.3	O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1	10.1021/jm901692q
		CHEMBL1083787	6757	15	None	-	1	Human	4.5	pIC50	=	4.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	370	7	2	3	4.3	O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1	10.1021/jm901692q
		180	401	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-58	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2726	919	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-87	72	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL1350036	67797	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1909062	67797	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		9807658	64546	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	8	2	6	6.1	CN(C)c1nc(NC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181466	64546	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	8	2	6	6.1	CN(C)c1nc(NC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14151619	55415	0	None	-	0	Bovine	6.4	pIC50	=	6.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3c(O)cccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL161947	55415	0	None	-	0	Bovine	6.4	pIC50	=	6.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3c(O)cccc3OC[C@H]21	10.1021/jm00123a039
		2484	208293	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		CHEMBL990	208293	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		119584	2595	102	None	-2	5	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		1848	2595	102	None	-2	5	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		242	2595	102	None	-2	5	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL60889	2595	102	None	-2	5	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		DB11675	2595	102	None	-2	5	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		57345320	3832	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acsmedchemlett.8b00030
		9882	3832	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acsmedchemlett.8b00030
		CHEMBL3091687	3832	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acsmedchemlett.8b00030
		57345320	3832	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		9882	3832	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		CHEMBL3091687	3832	9	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		9904205	205850	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL83658	205850	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(02)00796-5
		9904205	205850	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL83658	205850	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	294	2	0	3	3.4	CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		10219	188796	37	None	-1	5	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL493439	188796	37	None	-1	5	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL50588	188796	37	None	-1	5	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		5472	205818	75	None	-1	3	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL1717	205818	75	None	-1	3	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL833	205818	75	None	-1	3	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		2406	100404	89	None	-16	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	100404	89	None	-16	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		14151652	96640	0	None	-	0	Bovine	7.4	pIC50	=	7.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	1	3	3.1	CCCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		CHEMBL263574	96640	0	None	-	0	Bovine	7.4	pIC50	=	7.4	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	1	3	3.1	CCCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		10231050	64334	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	6	2	6	5.5	CN(C)c1nc(NC2CCC(NC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181184	64334	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	551	6	2	6	5.5	CN(C)c1nc(NC2CCC(NC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		1836	2592	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	2592	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	2592	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	2592	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	2592	59	None	-43	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		4189	206922	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		10024943	97390	0	None	-	1	Bovine	6.4	pIC50	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26975	97390	0	None	-	1	Bovine	6.4	pIC50	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52485	97390	0	None	-	1	Bovine	6.4	pIC50	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10429859	12042	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL1183429	12042	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL296395	12042	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		10092409	12046	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1183479	12046	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL299561	12046	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10319624	98987	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27991	98987	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL298534	98987	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		3082597	99559	8	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	99559	8	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9975915	99736	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL284912	99736	0	None	-	1	Bovine	5.4	pIC50	=	5.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10072866	197475	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51561	197475	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL56990	197475	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		5318	15576	49	None	-1	13	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	15576	49	None	-1	13	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	15576	49	None	-1	13	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		5353853	17986	47	None	-16	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	17986	47	None	-16	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	17986	47	None	-16	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		3952	1888	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5353646	1888	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5443	1888	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5702063	1888	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL1331786	1888	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL420	1888	38	None	-3	12	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		135	2532	43	None	-4	58	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-4	58	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-4	58	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-4	58	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-4	58	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		10660	14416	58	None	-43	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	-43	12	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		6918276	15611	7	None	-16	8	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	15611	7	None	-16	8	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		3198	205513	76	None	-19	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-19	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-19	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		19426635	205593	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL81485	205593	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
		44390456	64901	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	9	1	6	6.7	CN(Cc1ccc(Br)cc1OC(F)(F)F)CC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.05.121
		CHEMBL182235	64901	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	9	1	6	6.7	CN(Cc1ccc(Br)cc1OC(F)(F)F)CC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.05.121
		1547484	940	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	940	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	940	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	940	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	940	74	None	-5	20	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL1441214	39817	0	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1476898	39817	0	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		44390715	123820	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	5.2	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL362400	123820	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	5.2	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		11204090	69836	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(NC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL193771	69836	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(NC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		23027527	196792	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		CHEMBL565551	196792	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
		10381889	107069	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		CHEMBL315772	107069	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(02)00796-5
		10381889	107069	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL315772	107069	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	328	2	0	3	4.1	CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1	10.1016/s0960-894x(01)00721-1
		5198	19433	54	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		CHEMBL12948	19433	54	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		2247	505	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-58	42	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		3117	207841	103	None	-2	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	207841	103	None	-2	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		1353	1911	93	None	-190	83	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-190	83	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-190	83	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-190	83	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-190	83	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		44401671	70266	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	1	7	4.9	CN(C)c1nc(NCC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL194173	70266	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	587	7	1	7	4.9	CN(C)c1nc(NCC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		9980269	99083	0	None	-	1	Bovine	6.3	pIC50	=	6.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280586	99083	0	None	-	1	Bovine	6.3	pIC50	=	6.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54266	99083	0	None	-	1	Bovine	6.3	pIC50	=	6.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10251234	11245	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	11245	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	11245	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10476735	13731	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1195096	13731	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL553833	13731	0	None	-	0	Bovine	5.3	pIC50	=	5.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10364722	99085	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	99085	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	99085	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		44318454	206009	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		CHEMBL84931	206009	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for human cloned Alpha-2A adrenergic receptorBinding affinity for human cloned Alpha-2A adrenergic receptor	ChEMBL	312	2	0	3	3.5	CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1	10.1016/s0960-894x(01)00721-1
		14450361	56073	0	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	275	3	0	3	3.4	CCCN1CCC[C@@H]2c3c(OC)cc(C)cc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162510	56073	0	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	275	3	0	3	3.4	CCCN1CCC[C@@H]2c3c(OC)cc(C)cc3OC[C@H]21	10.1021/jm00123a039
		44390752	122996	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	523	6	1	6	5.4	CN(C)c1nc(NC2CCN(Cc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL360876	122996	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	523	6	1	6	5.4	CN(C)c1nc(NC2CCN(Cc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL508338	188966	0	None	-6	6	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		11057	176149	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	176149	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	176149	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	176149	23	None	-1	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		135398745	2914	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	-93	65	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		1201549	597	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-33	20	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		3598	187821	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	187821	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		10243700	56283	1	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162955	56283	1	None	-	0	Bovine	6.3	pIC50	=	6.3	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm00123a039
		11204090	63507	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(N[C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL180003	63507	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	587	7	2	7	5.1	CN(C)c1nc(N[C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		44401449	71094	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	544	6	2	6	5.0	O=S(=O)(NC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		CHEMBL195346	71094	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	544	6	2	6	5.0	O=S(=O)(NC1CCC(Nc2ncc3ccccc3n2)CC1)c1ccc(Br)cc1OC(F)(F)F	10.1016/j.bmcl.2005.03.052
		10303307	64476	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	7	2	6	5.8	CN(C)c1nc(NC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181393	64476	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	565	7	2	6	5.8	CN(C)c1nc(NC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		1549008	205680	85	None	-	1	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		CHEMBL822	205680	85	None	-	1	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		2520	204008	70	None	-6	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL1280	204008	70	None	-6	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL6966	204008	70	None	-6	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		133	2496	52	None	-23	42	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-23	42	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-23	42	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-23	42	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-23	42	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		44401508	69821	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	433	10	2	6	3.6	CCCCS(=O)(=O)NCC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.03.052
		CHEMBL193666	69821	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	433	10	2	6	3.6	CCCCS(=O)(=O)NCC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1	10.1016/j.bmcl.2005.03.052
		45485062	197168	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		CHEMBL567993	197168	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
		12488	1657	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-6	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL1200633	208600	3	None	-7	8	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		145949343	162932	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	404	6	2	4	3.9	c1ccc2c(c1)CN[C@@H](CN(CC[C@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2	10.1021/acsmedchemlett.8b00030
		CHEMBL4174290	162932	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin)Inhibition of adrenergic alpha2A receptor (unknown origin)	ChEMBL	404	6	2	4	3.9	c1ccc2c(c1)CN[C@@H](CN(CC[C@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2	10.1021/acsmedchemlett.8b00030
		2142	3096	58	None	-2	36	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		4920903	3096	58	None	-2	36	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		502	3096	58	None	-2	36	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		5775	3096	58	None	-2	36	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		CHEMBL597	3096	58	None	-2	36	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		DB00692	3096	58	None	-2	36	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		102	4127	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		3659	4127	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		8969	4127	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		CHEMBL15245	4127	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		DB01392	4127	48	None	-5	49	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		73453	29616	24	None	-3	17	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	29616	24	None	-3	17	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		44390710	64589	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	4.9	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C(F)(F)F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181632	64589	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	457	5	2	5	4.9	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(C(F)(F)F)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		10252000	98547	0	None	-	1	Bovine	5.2	pIC50	=	5.2	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27650	98547	0	None	-	1	Bovine	5.2	pIC50	=	5.2	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50188	98547	0	None	-	1	Bovine	5.2	pIC50	=	5.2	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		2162	41514	100	None	1	6	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		CHEMBL1491	41514	100	None	1	6	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		CHEMBL5082142	214787	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		c1cnc2c(c1)CN[C@@H](CN(CCCCN1CCOCC1)[C@H]1CCCc3cccnc31)C2	10.1021/acs.jmedchem.1c01564
		10357986	29905	2	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	309	3	0	3	3.9	COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm010992z
		CHEMBL138809	29905	2	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of idazoxane binding to noradrenaline alpha-2 receptorInhibition of idazoxane binding to noradrenaline alpha-2 receptor	ChEMBL	309	3	0	3	3.9	COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm010992z
		11080	29085	79	None	1	6	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	29085	79	None	1	6	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		44390706	122033	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	467	5	2	5	4.6	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Br)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL359510	122033	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	467	5	2	5	4.6	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Br)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14151702	56346	1	None	-	0	Bovine	6.2	pIC50	=	6.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	245	2	1	3	2.7	CCCN1CCC=C2c3cc(O)ccc3OCC21	10.1021/jm00123a039
		CHEMBL163061	56346	1	None	-	0	Bovine	6.2	pIC50	=	6.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	245	2	1	3	2.7	CCCN1CCC=C2c3cc(O)ccc3OCC21	10.1021/jm00123a039
		6761	67799	19	None	-6	18	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-6	18	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		1752	45761	59	None	-2	5	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		CHEMBL153062	45761	59	None	-2	5	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		2286	3183	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-13	30	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL1458880	37850	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		9895868	12899	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL1188966	12899	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL537846	12899	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		9895868	69582	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL193438	69582	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	615	9	2	7	5.6	CN(C)c1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		134551	358	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	358	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	358	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	358	27	None	-3	21	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		16718917	181682	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	412	6	1	4	5.0	CC1=C(CCN(C)C)c2cc(NS(=O)(=O)c3csc4ccccc34)ccc2C1	10.1021/jm8009469
		CHEMBL477650	181682	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human adrenergic alpha2A receptorInhibition of human adrenergic alpha2A receptor	ChEMBL	412	6	1	4	5.0	CC1=C(CCN(C)C)c2cc(NS(=O)(=O)c3csc4ccccc34)ccc2C1	10.1021/jm8009469
		168281847	191036	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assay	ChEMBL	310	3	1	4	3.6	COc1ccc(/C=C2\CCc3c(O)cccc3C2=O)cc1OC	10.1016/j.ejmech.2021.113964
		CHEMBL5187030	191036	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assay	ChEMBL	310	3	1	4	3.6	COc1ccc(/C=C2\CCc3c(O)cccc3C2=O)cc1OC	10.1016/j.ejmech.2021.113964
		14151613	56490	0	None	-	0	Bovine	7.2	pIC50	=	7.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	0	3	3.0	CCCN1CCC[C@@H]2c3c(OC)cccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL163281	56490	0	None	-	0	Bovine	7.2	pIC50	=	7.2	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	261	3	0	3	3.0	CCCN1CCC[C@@H]2c3c(OC)cccc3OC[C@H]21	10.1021/jm00123a039
		44390726	122404	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	449	7	2	7	3.9	COc1cc(OC)cc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		CHEMBL360081	122404	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	449	7	2	7	3.9	COc1cc(OC)cc(C(=O)N[C@H]2CC[C@@H](Nc3nc(N(C)C)c4ccccc4n3)CC2)c1	10.1016/j.bmcl.2005.05.121
		23027245	197128	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		CHEMBL567791	197128	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]MK-912 from human adrenergic alpha2A receptorDisplacement of [3H]MK-912 from human adrenergic alpha2A receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
		1971	2866	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-8	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4211	57822	83	None	-1	4	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		CHEMBL1670	57822	83	None	-1	4	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		1028	291	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		139148732	291	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		479	291	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		5816	291	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		CHEMBL679	291	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		DB00668	291	71	None	-48	30	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		44390750	63478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	423	5	2	5	4.5	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL179878	63478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	423	5	2	5	4.5	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		14151647	55663	1	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		CHEMBL162170	55663	1	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	2	1	3	2.7	CCCN1CCC[C@@H]2c3cccc(O)c3OC[C@H]21	10.1021/jm00123a039
		3082597	99559	8	None	-	1	Bovine	6.1	pIC50	=	6.1	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	99559	8	None	-	1	Bovine	6.1	pIC50	=	6.1	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		12575	1988	30	None	-5	17	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/s0960-894x(99)00591-0
		54459	1988	30	None	-5	17	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/s0960-894x(99)00591-0
		CHEMBL10316	1988	30	None	-5	17	Human	8.1	pIC50	=	8.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/s0960-894x(99)00591-0
		102	4127	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		3659	4127	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		8969	4127	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		CHEMBL15245	4127	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		DB01392	4127	48	None	-5	49	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		118112300	155994	18	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity at alpha2A-adrenergic receptor (unknown origin)Antagonist activity at alpha2A-adrenergic receptor (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
		CHEMBL4061793	155994	18	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity at alpha2A-adrenergic receptor (unknown origin)Antagonist activity at alpha2A-adrenergic receptor (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
		CHEMBL5093818	215445	3	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of alpha 2A adrenergic receptor (unknown origin)Inhibition of alpha 2A adrenergic receptor (unknown origin)	ChEMBL		None	None	None		CN(CCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21)C1CCC(F)(F)CC1	10.1021/acs.jmedchem.1c01564
		3191	102858	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		1816	2540	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		4205	2540	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		7241	2540	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		CHEMBL654	2540	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		DB00370	2540	102	None	-51	18	Human	7.1	pIC50	=	7.1	Binding	Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1016/s0960-894x(99)00591-0
		44401460	70907	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	391	7	2	6	2.5	CN(C)c1nc(NCC2CCC(CNS(C)(=O)=O)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		CHEMBL195123	70907	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	391	7	2	6	2.5	CN(C)c1nc(NCC2CCC(CNS(C)(=O)=O)CC2)nc2ccccc12	10.1016/j.bmcl.2005.03.052
		14151595	56511	0	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	231	2	0	2	3.0	CCCN1CCC[C@@H]2c3ccccc3OC[C@H]21	10.1021/jm00123a039
		CHEMBL163532	56511	0	None	-	0	Bovine	7.1	pIC50	=	7.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	231	2	0	2	3.0	CCCN1CCC[C@@H]2c3ccccc3OC[C@H]21	10.1021/jm00123a039
		70788951	27155	1	None	-1	5	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1366	27155	1	None	-1	5	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		46227396	201640	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	420	4	2	6	3.4	O=S(=O)(Nc1ccc2c(c1)C(C1CCNC1)=CC2)c1c(Cl)nc2sccn12	10.1016/j.bmc.2009.08.006
		CHEMBL605938	201640	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human alpha-2a adrenergic receptorInhibition of human alpha-2a adrenergic receptor	ChEMBL	420	4	2	6	3.4	O=S(=O)(Nc1ccc2c(c1)C(C1CCNC1)=CC2)c1c(Cl)nc2sccn12	10.1016/j.bmc.2009.08.006
		42636941	178949	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptorDisplacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		CHEMBL470432	178949	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptorDisplacement of [3H]RX821002 form human recombinant alpha2A adrenergic receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
		8447	188949	84	None	-4	13	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	188949	84	None	-4	13	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		2389	3331	118	None	-77	67	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-77	67	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-77	67	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-77	67	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-77	67	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		44390499	129657	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	8	2	6	6.0	CN(C)c1nc(NCC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL367355	129657	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	579	8	2	6	6.0	CN(C)c1nc(NCC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		135398737	958	93	None	-26	89	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-26	89	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-26	89	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-26	89	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-26	89	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		213	3853	55	None	-10	44	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	3853	55	None	-10	44	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	3853	55	None	-10	44	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	3853	55	None	-10	44	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	3853	55	None	-10	44	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		3082597	99559	8	None	-	1	Bovine	5.0	pIC50	=	5.0	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	99559	8	None	-	1	Bovine	5.0	pIC50	=	5.0	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		36324	27123	76	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		CHEMBL1365675	27123	76	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		1548953	207679	27	None	-1	17	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	207679	27	None	-1	17	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		14450364	56003	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	1	0	3	2.6	COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		CHEMBL162449	56003	0	None	-	0	Bovine	6.0	pIC50	=	6.0	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor at 1 uM	ChEMBL	247	1	0	3	2.6	COc1cc(C)cc2c1[C@H]1CCCN(C)[C@@H]1CO2	10.1021/jm00123a039
		44390768	64474	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	434	6	2	7	3.8	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc([N+](=O)[O-])c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		CHEMBL181383	64474	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsInhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	ChEMBL	434	6	2	7	3.8	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3cccc([N+](=O)[O-])c3)CC2)nc2ccccc12	10.1016/j.bmcl.2005.05.121
		1562	899	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		5312114	899	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		CHEMBL17645	899	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		CHEMBL195380	899	13	None	-	2	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912	ChEMBL	475	7	3	6	4.6	Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2	10.1016/j.bmcl.2005.03.052
		441383	20333	57	None	-2	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	20333	57	None	-2	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		164612037	185377	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	185377	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		168290235	192968	0	None	-40	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-40	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-40	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168294767	193019	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168295528	193031	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-11	20	Human	9.2	pKd	=	9.2	Binding	Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		118714540	114511	0	None	5	4	Human	9.0	pKd	=	9.0	Binding	Displacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 minsDisplacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 mins	ChEMBL	677	13	6	15	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(CCC(=O)Nc5ccc(OC(C)=O)c([N+](=O)[O-])c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/ml5002486
		CHEMBL3335523	114511	0	None	5	4	Human	9.0	pKd	=	9.0	Binding	Displacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 minsDisplacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from human adenosine A2a receptor K150A mutant expressed in COS-7 cells assessed as radioligand Kd compound preincubated for 30 mins	ChEMBL	677	13	6	15	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(CCC(=O)Nc5ccc(OC(C)=O)c([N+](=O)[O-])c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/ml5002486
		521	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		5311068	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		835	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		CHEMBL778	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		DB00633	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm990569e
		521	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		5311068	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		835	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		CHEMBL778	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		DB00633	1404	69	None	-2	7	Rat	10.8	pKi	=	10.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		49781228	17205	1	None	2	4	Human	10.6	pKi	=	10.6	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		CHEMBL1256414	17205	1	None	2	4	Human	10.6	pKi	=	10.6	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		155540329	172475	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	426	7	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4482861	172475	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	426	7	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		78114674	173726	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	380	7	0	7	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4536304	173726	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	380	7	0	7	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		155513359	169763	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	471	8	0	8	3.9	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cccc([N+](=O)[O-])c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4438801	169763	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	471	8	0	8	3.9	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cccc([N+](=O)[O-])c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		49781228	17205	1	None	2	4	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		CHEMBL1256414	17205	1	None	2	4	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		49781228	17205	1	None	2	4	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		CHEMBL1256414	17205	1	None	2	4	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	196	1	1	1	2.4	c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21	10.1021/jm1006269
		11271808	60994	0	None	1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	490	9	0	7	3.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OCCN(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL176261	60994	0	None	1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	490	9	0	7	3.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OCCN(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		11306100	168507	0	None	-3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	477	9	0	7	3.5	COCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL435352	168507	0	None	-3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	477	9	0	7	3.5	COCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		1588	2325	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	1	44	Human	9.9	pKi	=	9.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		52944548	17152	0	None	1	4	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.0	CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255723	17152	0	None	1	4	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.0	CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		52941512	17198	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256378	17198	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		135519400	63894	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	419	5	1	6	3.2	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL180470	63894	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	419	5	1	6	3.2	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1	10.1021/jm049619s
		49781222	17251	0	None	2	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	3.0	C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256609	17251	0	None	2	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	3.0	C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		46224879	201547	3	None	-1	7	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL605405	201547	3	None	-1	7	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		124	2981	47	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		2032	2981	47	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		4636	2981	47	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		CHEMBL762	2981	47	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		DB00935	2981	47	None	-4	33	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		44330168	4319	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL100879	4319	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		11225779	107732	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cc(F)ccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL319119	107732	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cc(F)ccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324972	163372	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL419316	163372	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324972	163372	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL419316	163372	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44324800	206948	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91157	206948	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44324972	163372	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL419316	163372	0	None	-2	4	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		44324800	206948	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL91157	206948	0	None	-5	7	Human	9.5	pKi	=	9.5	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		78114597	172484	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	356	6	0	6	2.6	CCOP(=O)(OCC)C1N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4483022	172484	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	356	6	0	6	2.6	CCOP(=O)(OCC)C1N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		49781887	17144	0	None	3	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		CHEMBL1255617	17144	0	None	3	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		9837136	99938	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm990569e
		CHEMBL286269	99938	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm990569e
		9837136	99938	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm000128r
		CHEMBL286269	99938	2	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3ccsc32)c[nH]1	10.1021/jm000128r
		108094	3423	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		526	3423	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		528	3423	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		CHEMBL10332	3423	27	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1021/jm800250z
		10531	1420	21	None	-5	23	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	1420	21	None	-5	23	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	1420	21	None	-5	23	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	1420	21	None	-5	23	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	1420	21	None	-5	23	Human	9.4	pKi	=	9.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		10056237	13744	0	None	47	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	817	13	6	6	7.3	O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1195197	13744	0	None	47	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	817	13	6	6	7.3	O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL554019	13744	0	None	47	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	817	13	6	6	7.3	O=C(NCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		2803	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		516	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		704	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		CHEMBL134	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		DB00575	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		2803	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		516	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		704	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		CHEMBL134	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		DB00575	955	58	None	1	19	Rat	9.4	pKi	=	9.4	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		11259744	60796	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	461	6	0	7	3.4	CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL176116	60796	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	461	6	0	7	3.4	CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		52948958	17153	0	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.4	CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255724	17153	0	None	-1	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.4	CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1	10.1021/jm1006269
		102	4127	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		3659	4127	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		8969	4127	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		CHEMBL15245	4127	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		DB01392	4127	48	None	-5	49	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/s0960-894x(00)00068-8
		52943739	17159	0	None	2	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12	10.1021/jm1006269
		CHEMBL1255771	17159	0	None	2	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	210	1	1	1	2.6	C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12	10.1021/jm1006269
		44387789	60575	0	None	-2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	433	6	0	6	3.5	COc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL176002	60575	0	None	-2	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	433	6	0	6	3.5	COc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		44330114	108082	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL319530	108082	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324906	206787	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1	10.1016/s0960-894x(03)00525-0
		CHEMBL90247	206787	0	None	3	3	Human	9.3	pKi	=	9.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1	10.1016/s0960-894x(03)00525-0
		49781223	17252	0	None	2	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.3	CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256610	17252	0	None	2	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	2	1	1	3.3	CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		9815633	99635	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		CHEMBL284213	99635	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		9815633	99635	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		CHEMBL284213	99635	3	None	6	6	Rat	9.3	pKi	=	9.3	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		49781005	17214	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256503	17214	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		49781887	17144	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		CHEMBL1255617	17144	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		11214030	60544	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	491	8	0	8	3.1	COCC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL175853	60544	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	491	8	0	8	3.1	COCC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		107715	200945	22	None	-6	19	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	200945	22	None	-6	19	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	200945	22	None	-6	19	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		11765813	12978	0	None	60	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	788	11	6	6	6.5	O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1189483	12978	0	None	60	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	788	11	6	6	6.5	O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL538808	12978	0	None	60	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	788	11	6	6	6.5	O=C(NCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		13938361	185363	0	None	141	2	Bovine	9.1	pKi	=	9.1	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@@H]1CCN2CCc3c(oc4ccccc34)[C@@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		CHEMBL48603	185363	0	None	141	2	Bovine	9.1	pKi	=	9.1	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@@H]1CCN2CCc3c(oc4ccccc34)[C@@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		1043	1582	14	None	-8	28	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	1582	14	None	-8	28	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	1582	14	None	-8	28	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	1582	14	None	-8	28	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	1582	14	None	-8	28	Human	9.1	pKi	=	9.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		44324800	206948	0	None	-5	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL91157	206948	0	None	-5	7	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324887	165015	0	None	2	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL422597	165015	0	None	2	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	419	6	0	6	3.1	COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44325050	207281	0	None	-3	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL93171	207281	0	None	-3	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44126269	201484	5	None	-2	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
		CHEMBL605081	201484	5	None	-2	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
		49781224	17143	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.7	CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255616	17143	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	238	3	1	1	3.7	CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		12114852	13320	0	None	31	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	774	10	6	6	6.1	O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1192051	13320	0	None	31	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	774	10	6	6	6.1	O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL543232	13320	0	None	31	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	774	10	6	6	6.1	O=C(NCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		11785068	60556	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	7	3.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C5CC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL175911	60556	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	7	3.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C5CC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		11260018	63859	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	473	7	0	7	3.6	C=CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL180322	63859	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	473	7	0	7	3.6	C=CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		71450907	78939	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL2112978	78939	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4OC[C@H]32)CC1	10.1021/jm049619s
		44324937	206913	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1	10.1016/s0960-894x(03)00525-0
		CHEMBL90943	206913	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	389	5	0	5	3.1	C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1	10.1016/s0960-894x(03)00525-0
		2142	3096	58	None	1	36	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		4920903	3096	58	None	1	36	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		502	3096	58	None	1	36	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		5775	3096	58	None	1	36	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		CHEMBL597	3096	58	None	1	36	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		DB00692	3096	58	None	1	36	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		155547631	173694	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	432	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4535472	173694	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	432	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C3CCCCC3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		11318438	165984	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	524	7	0	8	4.1	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)c5ccncc5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL425324	165984	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	524	7	0	8	4.1	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)c5ccncc5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		9805944	56227	37	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [125I]HEAT from adrenergic alpha2A receptorDisplacement of [125I]HEAT from adrenergic alpha2A receptor	ChEMBL	462	7	2	3	4.7	CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	10.1021/jm800510m
		CHEMBL1627	56227	37	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [125I]HEAT from adrenergic alpha2A receptorDisplacement of [125I]HEAT from adrenergic alpha2A receptor	ChEMBL	462	7	2	3	4.7	CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1	10.1021/jm800510m
		44330635	208426	0	None	-2	2	Human	9.0	pKi	=	9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1ccccc1/C=C(\C)CN1CCN(C[C@@H]2ON=C3c4cc(OC)c(OC)cc4OC[C@H]32)CC1	10.1016/j.bmcl.2004.03.031
		CHEMBL99868	208426	0	None	-2	2	Human	9.0	pKi	=	9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1ccccc1/C=C(\C)CN1CCN(C[C@@H]2ON=C3c4cc(OC)c(OC)cc4OC[C@H]32)CC1	10.1016/j.bmcl.2004.03.031
		52950140	17158	0	None	1	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	1	1	1	3.0	CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1255770	17158	0	None	1	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	224	1	1	1	3.0	CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1	10.1021/jm1006269
		44330668	4436	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL101596	4436	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44330617	96620	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL263424	96620	0	None	-5	2	Human	9.0	pKi	=	9.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44371848	13625	0	None	15	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	845	15	6	6	8.1	O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1194334	13625	0	None	15	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	845	15	6	6	8.1	O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL551711	13625	0	None	15	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	845	15	6	6	8.1	O=C(NCCCCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		9837551	101624	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	232	1	3	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCO2	10.1021/jm960359r
		CHEMBL298936	101624	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	232	1	3	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCO2	10.1021/jm960359r
		12114853	13028	0	None	35	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	803	12	6	6	6.9	O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1189875	13028	0	None	35	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	803	12	6	6	6.9	O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL539606	13028	0	None	35	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	803	12	6	6	6.9	O=C(NCCCCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		10847653	57445	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	240	0	1	2	2.6	C1=NC[C@]2(CC[C@@H]3Cc4ccccc4C[C@H]3C2)N1	10.1021/jm001040g
		CHEMBL165529	57445	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	240	0	1	2	2.6	C1=NC[C@]2(CC[C@@H]3Cc4ccccc4C[C@H]3C2)N1	10.1021/jm001040g
		11785961	63280	0	None	-6	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	535	13	0	8	4.0	CCOCCOCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL179237	63280	0	None	-6	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	535	13	0	8	4.0	CCOCCOCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		11190988	131803	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	6	4.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC5CCCC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL369378	131803	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	487	7	0	6	4.8	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC5CCCC5)cc4OC[C@H]32)CC1	10.1021/jm049619s
		136019934	144530	0	None	-7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		CHEMBL390718	144530	0	None	-7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		44324737	207238	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL92860	207238	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44324737	207238	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL92860	207238	0	None	-2	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1021/jm049619s
		10123375	13250	0	None	123	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	760	9	6	6	5.8	O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1191431	13250	0	None	123	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	760	9	6	6	5.8	O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL542527	13250	0	None	123	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	760	9	6	6	5.8	O=C(NCCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		13938356	185078	0	None	154	2	Bovine	8.9	pKi	=	8.9	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN(C1CCN2CCc3c(oc4ccccc34)C2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		CHEMBL48558	185078	0	None	154	2	Bovine	8.9	pKi	=	8.9	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN(C1CCN2CCc3c(oc4ccccc34)C2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		44330369	111582	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL328195	111582	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccsc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		102	4127	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		3659	4127	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		8969	4127	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		CHEMBL15245	4127	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		DB01392	4127	48	None	-5	49	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2005.03.116
		44325049	111523	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL327875	111523	0	None	-2	3	Human	8.9	pKi	=	8.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		10707358	179285	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	272	4	1	3	3.2	c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL47313	179285	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	272	4	1	3	3.2	c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		12575	1988	30	None	1	17	Bovine	8.8	pKi	=	8.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm00366a007
		54459	1988	30	None	1	17	Bovine	8.8	pKi	=	8.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm00366a007
		CHEMBL10316	1988	30	None	1	17	Bovine	8.8	pKi	=	8.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm00366a007
		9815610	99933	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		CHEMBL286246	99933	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		124	2981	47	None	-5	33	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		2032	2981	47	None	-5	33	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		4636	2981	47	None	-5	33	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		CHEMBL762	2981	47	None	-5	33	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		DB00935	2981	47	None	-5	33	Bovine	8.8	pKi	=	8.8	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		9815610	99933	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		CHEMBL286246	99933	19	None	13	4	Rat	8.8	pKi	=	8.8	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		11200476	78931	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for Alpha-2A adrenergic receptorBinding affinity for Alpha-2A adrenergic receptor	ChEMBL	402	5	0	5	3.2	CN1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112970	78931	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity for Alpha-2A adrenergic receptorBinding affinity for Alpha-2A adrenergic receptor	ChEMBL	402	5	0	5	3.2	CN1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		9837600	23320	0	None	12	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	236	0	1	3	1.9	NC1=NC2(CCc3cccc(Cl)c3C2)CO1	10.1021/jm00020a021
		CHEMBL133231	23320	0	None	12	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	236	0	1	3	1.9	NC1=NC2(CCc3cccc(Cl)c3C2)CO1	10.1021/jm00020a021
		46891598	7176	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]rauwolscine from adrenergic alpha2A receptorDisplacement of [3H]rauwolscine from adrenergic alpha2A receptor	ChEMBL	402	5	0	5	3.2	CN1CC2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2010.04.099
		CHEMBL1085510	7176	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]rauwolscine from adrenergic alpha2A receptorDisplacement of [3H]rauwolscine from adrenergic alpha2A receptor	ChEMBL	402	5	0	5	3.2	CN1CC2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2010.04.099
		42266865	15603	2	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	389	6	1	4	3.4	COc1ccccc1N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221498	15603	2	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	389	6	1	4	3.4	COc1ccccc1N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		2142	3096	58	None	-2	36	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		4920903	3096	58	None	-2	36	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		502	3096	58	None	-2	36	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		5775	3096	58	None	-2	36	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		CHEMBL597	3096	58	None	-2	36	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		DB00692	3096	58	None	-2	36	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/np50094a001
		10176999	103554	21	None	11	3	Human	8.8	pKi	=	8.8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
		CHEMBL308570	103554	21	None	11	3	Human	8.8	pKi	=	8.8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	231	2	2	4	2.2	Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2	10.1021/jm9605142
		44330653	208232	0	None	-8	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL98646	208232	0	None	-8	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	469	7	0	8	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccs4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44330645	208434	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL99916	208434	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	453	7	0	8	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccco4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		10350094	13817	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	746	8	6	6	5.4	O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1195716	13817	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	746	8	6	6	5.4	O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL555190	13817	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	746	8	6	6	5.4	O=C(NCCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		49781005	17214	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256503	17214	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		13123525	189198	0	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		CHEMBL51131	189198	0	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		13123534	189453	1	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		CHEMBL51358	189453	1	None	-	1	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		71461647	78933	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	439	5	0	5	4.4	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		CHEMBL2112972	78933	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	439	5	0	5	4.4	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		71456240	78942	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	415	6	0	5	3.8	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(C/C=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL2112982	78942	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	415	6	0	5	3.8	COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(C/C=C/c2ccccc2)CC1	10.1021/jm049619s
		102	4127	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		3659	4127	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		8969	4127	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		CHEMBL15245	4127	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		DB01392	4127	48	None	-5	49	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2006.12.094
		12576	514	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		71310	514	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		CHEMBL353972	514	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		DB11481	514	94	None	-2	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm1006269
		44330368	112192	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	479	7	1	8	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(O)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL329065	112192	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	479	7	1	8	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(O)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		108094	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		526	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		528	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		CHEMBL10332	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	10.1016/j.ejmech.2014.05.057
		42631003	199618	13	None	-10	8	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL592752	199618	13	None	-10	8	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		10198135	205125	3	None	43	3	Human	8.0	pKi	=	8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	203	3	2	3	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1	10.1021/jm9605142
		CHEMBL77913	205125	3	None	43	3	Human	8.0	pKi	=	8	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	203	3	2	3	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1	10.1021/jm9605142
		2389	3331	118	None	-77	67	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		5073	3331	118	None	-77	67	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		96	3331	118	None	-77	67	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		CHEMBL85	3331	118	None	-77	67	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		DB00734	3331	118	None	-77	67	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		44401243	168494	0	None	-4	9	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL435301	168494	0	None	-4	9	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		49836302	18566	1	None	1	3	Human	7.0	pKi	=	7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276139	18566	1	None	1	3	Human	7.0	pKi	=	7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml400232p
		10176715	157134	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	2	2.4	C1=NCC(CC2=Cc3ccccc3CC2)N1	10.1021/jm001040g
		CHEMBL407509	157134	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	2	2.4	C1=NCC(CC2=Cc3ccccc3CC2)N1	10.1021/jm001040g
		242	470	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	470	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	470	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	470	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	470	124	None	-26	51	Human	7.0	pKi	=	7	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		250	3386	8	None	-2818	12	Human	7.0	pKi	=	7	Binding	Compound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		5311416	3386	8	None	-2818	12	Human	7.0	pKi	=	7	Binding	Compound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		CHEMBL69733	3386	8	None	-2818	12	Human	7.0	pKi	=	7	Binding	Compound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assayCompound was evaluated for binding affinity against Alpha-2A adrenergic receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		135398737	958	93	None	-10	89	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		38	958	93	None	-10	89	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		722	958	93	None	-10	89	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		CHEMBL42	958	93	None	-10	89	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		DB00363	958	93	None	-10	89	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.08.011
		49836302	18566	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276139	18566	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/jm100977d
		49836302	18566	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml300064v
		CHEMBL1276139	18566	1	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@H](C)C1=NCCN1	10.1021/ml300064v
		13938357	101730	0	None	79	2	Bovine	7.0	pKi	=	7	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@H]1CCN2CCc3c(oc4ccccc34)[C@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		CHEMBL299595	101730	0	None	79	2	Bovine	7.0	pKi	=	7	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	364	4	1	5	1.7	CN([C@H]1CCN2CCc3c(oc4ccccc34)[C@H]2C1)S(=O)(=O)CCO	10.1021/jm00150a002
		135398737	958	93	None	-26	89	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	958	93	None	-26	89	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	958	93	None	-26	89	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	958	93	None	-26	89	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	958	93	None	-26	89	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		135398745	2914	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	2914	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	2914	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	2914	112	None	-93	65	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		2389	3331	118	None	-77	67	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	3331	118	None	-77	67	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	3331	118	None	-77	67	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	3331	118	None	-77	67	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	3331	118	None	-77	67	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		90644728	112752	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	1	2.1	CC1CN/C(=N/c2ccc3c(c2)CCCC3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289543	112752	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	1	2.1	CC1CN/C(=N/c2ccc3c(c2)CCCC3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305161	112752	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	1	2.1	CC1CN/C(=N/c2ccc3c(c2)CCCC3)N1	10.1016/j.ejmech.2014.05.057
		16090600	169181	0	None	-10	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	6	2	4	5.1	Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C	10.1021/jm060262x
		CHEMBL440594	169181	0	None	-10	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	6	2	4	5.1	Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C	10.1021/jm060262x
		10324985	76781	8	None	-741	17	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha-2A receptorBinding affinity to adrenergic alpha-2A receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL199824	76781	8	None	-741	17	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha-2A receptorBinding affinity to adrenergic alpha-2A receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL2068762	76781	8	None	-741	17	Human	6.0	pKi	=	6	Binding	Binding affinity to adrenergic alpha-2A receptorBinding affinity to adrenergic alpha-2A receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		127035062	136451	0	None	-3	19	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	136451	0	None	-3	19	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human recombinant alpha 2A receptor stably expressed in MDCK cells after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		10443343	18500	1	None	-	1	Bovine	6.0	pKi	=	6.0	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	0	5	0.5	CN1CCN(c2nccn3ccnc23)CC1	10.1021/jm00099a012
		CHEMBL127303	18500	1	None	-	1	Bovine	6.0	pKi	=	6.0	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	0	5	0.5	CN1CCN(c2nccn3ccnc23)CC1	10.1021/jm00099a012
		1782	2518	84	None	-5	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		241	2518	84	None	-5	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		4168	2518	84	None	-5	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		CHEMBL86	2518	84	None	-5	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		DB01233	2518	84	None	-5	22	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
		44574076	172461	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL448147	172461	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		9960497	117075	0	None	-309	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		CHEMBL3392246	117075	0	None	-309	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		57395731	71190	0	None	6	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956202	71190	0	None	6	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	4	1.7	CC(=O)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		44312037	204619	1	None	1	6	Human	5.0	pKi	=	5.0	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL73392	204619	1	None	1	6	Human	5.0	pKi	=	5.0	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	308	1	1	5	2.9	Brc1c(NC2=NCCS2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		3151	1462	97	None	-99	27	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		945	1462	97	None	-99	27	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		965	1462	97	None	-99	27	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		CHEMBL219916	1462	97	None	-99	27	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		DB01184	1462	97	None	-99	27	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
		12909387	62637	0	None	-33	2	Bovine	6.0	pKi	=	6.0	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	301	0	0	3	3.8	CN1CCC(=C2c3cc(C#N)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL178376	62637	0	None	-33	2	Bovine	6.0	pKi	=	6.0	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	301	0	0	3	3.8	CN1CCC(=C2c3cc(C#N)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		9904117	9402	3	None	1	4	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL111554	9402	3	None	1	4	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		11091738	118092	0	None	-1584	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		CHEMBL340641	118092	0	None	-1584	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		57402718	71189	2	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956201	71189	2	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	4	1.3	CC(Oc1ccccc1C=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		2803	955	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		516	955	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		704	955	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		CHEMBL134	955	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		DB00575	955	58	None	-1	19	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
		16090624	82401	0	None	-13	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL217278	82401	0	None	-13	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		4209	3163	75	None	-173	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	3163	75	None	-173	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	3163	75	None	-173	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	3163	75	None	-173	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	3163	75	None	-173	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	3163	75	None	-173	33	Bovine	7.0	pKi	=	7.0	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		277	1301	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-33	50	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		1268096	16165	26	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL122404	16165	26	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		90644708	112742	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	5	3	3	2.4	CCNc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289530	112742	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	5	3	3	2.4	CCNc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304993	112742	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	5	3	3	2.4	CCNc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		68617	205527	62	None	-3	26	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	205527	62	None	-3	26	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	205527	62	None	-3	26	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		10769331	111533	0	None	-208	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	566	9	2	7	5.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1	10.1021/jm980077m
		CHEMBL327931	111533	0	None	-208	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	566	9	2	7	5.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1	10.1021/jm980077m
		197033	199152	64	None	-13	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		CHEMBL589390	199152	64	None	-13	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cellsDisplacement of [3H]MK-912 from human recombinant adrenergic alpha2A receptor expressed in insect Sf9 cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
		13298529	101219	57	None	134	2	Bovine	8.0	pKi	=	8.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	241	1	1	3	1.3	Brc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL295921	101219	57	None	134	2	Bovine	8.0	pKi	=	8.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	241	1	1	3	1.3	Brc1cccnc1N1CCNCC1	10.1021/jm00366a007
		71456238	78938	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	504	9	0	7	4.4	COc1cc2c(cc1OC)N(C)C[C@@H]1C2=NO[C@H]1CN1CCN(CCC/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		CHEMBL2112977	78938	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	504	9	0	7	4.4	COc1cc2c(cc1OC)N(C)C[C@@H]1C2=NO[C@H]1CN1CCN(CCC/C(C)=C/c2ccccc2)CC1	10.1021/jm049619s
		46934426	15625	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	431	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221591	15625	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	431	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		49781004	17213	0	None	2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256502	17213	0	None	2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1	10.1021/jm1006269
		44371755	48777	0	None	15	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL155866	48777	0	None	15	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	3	1	3	2.1	Cc1cccc(C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		90469115	185842	4	None	-36	17	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human adrenergic alpha 2A receptorBinding affinity to human adrenergic alpha 2A receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		CHEMBL4867565	185842	4	None	-36	17	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human adrenergic alpha 2A receptorBinding affinity to human adrenergic alpha 2A receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
		9809007	172564	8	None	-1905	6	Human	6.0	pKi	=	6.0	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		CHEMBL448620	172564	8	None	-1905	6	Human	6.0	pKi	=	6.0	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		10109188	166075	0	None	-43	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	4	1	4	4.6	CCc1c(C)nc2ccccc2c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		CHEMBL425803	166075	0	None	-43	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	4	1	4	4.6	CCc1c(C)nc2ccccc2c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		44574103	172588	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	250	2	0	4	2.4	c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL448908	172588	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	250	2	0	4	2.4	c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		162661022	181448	0	None	-	1	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4764318	181448	0	None	-	1	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		3168	9262	92	None	-123	21	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-123	21	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		1227	2489	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2331	2489	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		3957	2489	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		4992	2489	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		CHEMBL511	2489	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		DB06691	2489	43	None	-91	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
		2435	722	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		395	722	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		520	722	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		5386	722	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		CHEMBL844	722	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		DB00484	722	100	None	-2	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
		44574079	189309	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL512289	189309	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1	10.1016/j.bmcl.2009.03.166
		10531766	206997	0	None	-999	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	9	2	7	6.3	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		CHEMBL91415	206997	0	None	-999	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	9	2	7	6.3	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		62381476	112767	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	4	3	2	2.1	CCCNC(=N)Nc1ccc(N(C)C)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289536	112767	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	4	3	2	2.1	CCCNC(=N)Nc1ccc(N(C)C)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305461	112767	2	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	4	3	2	2.1	CCCNC(=N)Nc1ccc(N(C)C)cc1	10.1016/j.ejmech.2014.05.057
		122295	9868	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		CHEMBL114166	9868	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		122295	9868	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00019a001
		CHEMBL114166	9868	7	None	-1	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00019a001
		44574104	189489	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	353	4	1	4	3.3	CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL513871	189489	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	353	4	1	4	3.3	CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		145990586	166843	0	None	-89	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		CHEMBL4285281	166843	0	None	-89	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to andrenergic alpha2A receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
		2335	11848	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	11848	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	11848	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	11848	22	None	-5	12	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		176	398	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-3	31	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		44424855	85454	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL226636	85454	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		44325038	206916	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ncccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL90966	206916	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ncccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		127026052	137553	0	None	-7	19	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754496	137553	0	None	-7	19	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
		16090630	83237	0	None	-309	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO	10.1021/jm060262x
		CHEMBL218675	83237	0	None	-309	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO	10.1021/jm060262x
		10579368	106004	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	9	3	6	5.3	CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL313251	106004	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	9	3	6	5.3	CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		155526524	171185	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	364	6	0	6	2.4	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4459090	171185	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	364	6	0	6	2.4	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644720	112758	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	3	4	4	0.3	N=C(NCCO)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289524	112758	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	3	4	4	0.3	N=C(NCCO)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305319	112758	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	3	4	4	0.3	N=C(NCCO)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		44579230	181544	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
		CHEMBL476569	181544	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1	10.1016/j.bmcl.2008.08.055
		10316512	16867	2	None	-18	2	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	359	1	1	5	1.7	Brc1cnc(N2CCNCC2)c2ncc(Br)n12	10.1021/jm00099a012
		CHEMBL124926	16867	2	None	-18	2	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	359	1	1	5	1.7	Brc1cnc(N2CCNCC2)c2ncc(Br)n12	10.1021/jm00099a012
		10081626	21095	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	204	0	1	2	1.7	Fc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL131220	21095	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	204	0	1	2	1.7	Fc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		10262765	116555	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CCC1(CN=CN1)C2	10.1021/jm00020a021
		CHEMBL336332	116555	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CCC1(CN=CN1)C2	10.1021/jm00020a021
		398712	77869	5	None	-12	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cellsDisplacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		CHEMBL209324	77869	5	None	-12	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cellsDisplacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
		44325075	111765	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	465	8	0	8	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCC(=O)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328735	111765	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	465	8	0	8	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCC(=O)c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44292196	180006	2	None	5	2	Bovine	6.9	pKi	=	6.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	287	3	0	3	3.1	Clc1cccnc1N1CCN(Cc2ccccc2)CC1	10.1021/jm00366a007
		CHEMBL47471	180006	2	None	5	2	Bovine	6.9	pKi	=	6.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	287	3	0	3	3.1	Clc1cccnc1N1CCN(Cc2ccccc2)CC1	10.1021/jm00366a007
		9809007	172564	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		CHEMBL448620	172564	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		2775690	93011	53	None	-45	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenoceptor receptor (unknown origin)Binding affinity to alpha2A adrenoceptor receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		CHEMBL2441619	93011	53	None	-45	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenoceptor receptor (unknown origin)Binding affinity to alpha2A adrenoceptor receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
		9809007	172564	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL448620	172564	8	None	-1905	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		11380132	84419	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccccn1)C1=NCCN1	10.1021/jm0408215
		CHEMBL221989	84419	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccccn1)C1=NCCN1	10.1021/jm0408215
		1268096	16165	26	None	-42	4	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptorCompound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL122404	16165	26	None	-42	4	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptorCompound was evaluated for the ability to inhibit binding of [3H]nitrendipine to membrane homogenates of of rat alpha-2D adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12	10.1021/jm00019a001
		92766	106542	35	None	-12	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL31410	106542	35	None	-12	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		24839550	137315	14	None	-1	15	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752576	137315	14	None	-1	15	Human	6.9	pKi	=	6.9	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
		11246610	84312	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL221523	84312	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1	10.1021/jm0408215
		16090626	82135	0	None	-77	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	3	1	4	4.9	Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL216727	82135	0	None	-77	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	3	1	4	4.9	Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		44421258	84746	0	None	3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL1204386	84746	0	None	3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL222933	84746	0	None	3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		90644730	112771	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	3	3	2	1.7	CCNc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289544	112771	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	3	3	2	1.7	CCNc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305465	112771	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	3	3	2	1.7	CCNc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		71452341	83697	7	None	-4	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
		CHEMBL2205361	83697	7	None	-4	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
		44269006	32353	1	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	5	1	3	1.8	C=CCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		CHEMBL14107	32353	1	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	5	1	3	1.8	C=CCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		24906243	187248	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1	10.1021/jm800250z
		CHEMBL492648	187248	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1	10.1021/jm800250z
		1267	3804	49	None	-52	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		3035905	3804	49	None	-52	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		CHEMBL260374	3804	49	None	-52	26	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	10.1021/jm8003625
		2284	3182	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-12	29	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		9839050	112379	0	None	-263	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		CHEMBL329566	112379	0	None	-263	9	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		9928335	120097	2	None	-3	6	Rat	6.9	pKi	=	6.9	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		CHEMBL35093	120097	2	None	-3	6	Rat	6.9	pKi	=	6.9	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		CHEMBL4520788	213975	10	None	-6	25	Human	6.9	pKi	=	6.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA2A	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		3038525	13549	114	None	-2	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		CHEMBL119385	13549	114	None	-2	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	435	3	0	5	5.5	O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl	nan
		181743	178572	5	None	-645	22	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Clonidine from human adrenergic alpha2A receptorDisplacement of [3H]Clonidine from human adrenergic alpha2A receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	178572	5	None	-645	22	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]Clonidine from human adrenergic alpha2A receptorDisplacement of [3H]Clonidine from human adrenergic alpha2A receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		9827677	168422	0	None	-6456	7	Human	5.9	pKi	=	5.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	510	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL43491	168422	0	None	-6456	7	Human	5.9	pKi	=	5.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	510	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		10627021	107095	0	None	-933	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	577	9	2	5	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1	10.1021/jm980077m
		CHEMBL315914	107095	0	None	-933	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	577	9	2	5	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1	10.1021/jm980077m
		129211	3749	78	None	-120	15	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		2562	3749	78	None	-120	15	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		488	3749	78	None	-120	15	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		CHEMBL836	3749	78	None	-120	15	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		DB00706	3749	78	None	-120	15	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
		44292385	101121	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	270	3	1	3	2.6	c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL295186	101121	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	270	3	1	3	2.6	c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		10609673	103776	0	None	11	3	Human	6.9	pKi	=	6.9	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	233	4	2	4	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1OC	10.1021/jm9605142
		CHEMBL308863	103776	0	None	11	3	Human	6.9	pKi	=	6.9	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	233	4	2	4	2.5	COc1ccc(Nc2ncc[nH]2)c(C)c1OC	10.1021/jm9605142
		CHEMBL179334	63303	0	None	-7079	6	Human	5.9	pKi	=	5.9	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@H]1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		162664874	182176	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	519	9	5	11	1.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4782649	182176	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	519	9	5	11	1.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		71450550	83807	0	None	-2	16	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenergic receptorBinding affinity to alpha2A adrenergic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	83807	0	None	-2	16	Human	5.9	pKi	=	5.9	Binding	Binding affinity to alpha2A adrenergic receptorBinding affinity to alpha2A adrenergic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		9926529	9389	2	None	-1	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL111496	9389	2	None	-1	4	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		10221004	204231	0	None	-1	5	Human	5.9	pKi	=	5.9	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	5	2	5	0.9	CCS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70973	204231	0	None	-1	5	Human	5.9	pKi	=	5.9	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	5	2	5	0.9	CCS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		90644736	112772	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	3	2	3	2.3	CN(C)c1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289547	112772	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	3	2	3	2.3	CN(C)c1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305466	112772	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	3	2	3	2.3	CN(C)c1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		180	401	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-58	40	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2726	919	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-87	72	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		10475736	165863	0	None	-26	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	4	2	5	4.1	CN1CCN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CC1(C)C	10.1021/jm060262x
		CHEMBL424917	165863	0	None	-26	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	4	2	5	4.1	CN1CCN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CC1(C)C	10.1021/jm060262x
		3805301	101337	83	None	-1	2	Bovine	5.9	pKi	=	5.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		CHEMBL296787	101337	83	None	-1	2	Bovine	5.9	pKi	=	5.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		CHEMBL1350036	67797	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1909062	67797	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		44438148	93490	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL246229	93490	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		11779308	18503	8	None	4	2	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2nccn3c(Br)cnc23)CC1	10.1021/jm00099a012
		CHEMBL127318	18503	8	None	4	2	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2nccn3c(Br)cnc23)CC1	10.1021/jm00099a012
		44288877	168599	0	None	-1905	5	Human	4.9	pKi	=	4.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	549	7	1	5	4.3	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL43594	168599	0	None	-1905	5	Human	4.9	pKi	=	4.9	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	549	7	1	5	4.3	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		2484	208293	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		CHEMBL990	208293	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	nan
		599482	202984	9	None	-9	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
		CHEMBL6310	202984	9	None	-9	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
		119584	2595	102	None	-2	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		1848	2595	102	None	-2	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		242	2595	102	None	-2	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		CHEMBL60889	2595	102	None	-2	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		DB11675	2595	102	None	-2	5	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
		44579228	181654	0	None	-57	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		CHEMBL477608	181654	0	None	-57	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	467	7	2	7	2.9	CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		11265631	136409	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL373535	136409	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm061487a
		11265631	136409	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL373535	136409	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1cccnc1)C1=NCCN1	10.1021/jm0408215
		10317643	98540	0	None	-32	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	CC1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		CHEMBL276417	98540	0	None	-32	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	CC1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		2737203	183924	83	None	141	2	Bovine	7.9	pKi	=	7.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	188	1	1	4	0.4	N#Cc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL48137	183924	83	None	141	2	Bovine	7.9	pKi	=	7.9	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	188	1	1	4	0.4	N#Cc1cccnc1N1CCNCC1	10.1021/jm00366a007
		13123527	101790	3	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300053	101790	3	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		13123531	188241	0	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		CHEMBL49953	188241	0	None	-	1	Bovine	7.9	pKi	=	7.9	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		10219	188796	37	None	-1	5	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL493439	188796	37	None	-1	5	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		CHEMBL50588	188796	37	None	-1	5	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	nan
		11211035	85003	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL223836	85003	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm061487a
		11211035	85003	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL223836	85003	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	284	4	1	3	3.3	CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1	10.1021/jm0408215
		10376053	13135	0	None	2	3	Bovine	6.9	pKi	=	6.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		CHEMBL1190547	13135	0	None	2	3	Bovine	6.9	pKi	=	6.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		CHEMBL541088	13135	0	None	2	3	Bovine	6.9	pKi	=	6.9	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		16090622	82298	0	None	-165	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.4	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)C2)cc1	10.1021/jm060262x
		CHEMBL217202	82298	0	None	-165	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.4	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)C2)cc1	10.1021/jm060262x
		10070896	83196	0	None	-281	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	4	1	4	6.1	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1-c1ccccc1	10.1021/jm060262x
		CHEMBL218457	83196	0	None	-281	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	4	1	4	6.1	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1-c1ccccc1	10.1021/jm060262x
		44438166	93817	0	None	-33	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL247664	93817	0	None	-33	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	10.1016/j.bmcl.2006.12.094
		4428003	112764	17	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	179	3	3	2	1.4	CCOc1ccc(NC(=N)N)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289540	112764	17	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	179	3	3	2	1.4	CCOc1ccc(NC(=N)N)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305332	112764	17	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	179	3	3	2	1.4	CCOc1ccc(NC(=N)N)cc1	10.1016/j.ejmech.2014.05.057
		155566429	175927	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	378	7	0	6	2.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4587519	175927	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	378	7	0	6	2.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644758	112751	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	3	2	2	1.7	CCOc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289541	112751	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	3	2	2	1.7	CCOc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305160	112751	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	3	2	2	1.7	CCOc1ccc(/N=C2/NCC(C)N2)cc1	10.1016/j.ejmech.2014.05.057
		5472	205818	75	None	-1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL1717	205818	75	None	-1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		CHEMBL833	205818	75	None	-1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	nan
		10318507	58953	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cc(Cl)ccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL1689423	58953	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cc(Cl)ccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		2406	100404	89	None	-16	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	100404	89	None	-16	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		43260	5482	65	None	1	4	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	197	4	2	4	0.7	COc1ccc(OC)c(C(O)CN)c1	10.1021/jm030551a
		CHEMBL1076	5482	65	None	1	4	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	197	4	2	4	0.7	COc1ccc(OC)c(C(O)CN)c1	10.1021/jm030551a
		10758200	63417	0	None	-43	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		CHEMBL179648	63417	0	None	-43	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	322	4	0	3	3.2	c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		1836	2592	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	2592	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	2592	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	2592	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	2592	59	None	-43	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		44574135	189178	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	268	2	1	3	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL511211	189178	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	268	2	1	3	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1	10.1016/j.bmcl.2009.03.166
		90644702	112716	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	5	2	3	2.4	CCOc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289533	112716	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	5	2	3	2.4	CCOc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304532	112716	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	5	2	3	2.4	CCOc1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		44311789	204735	0	None	-1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	345	1	2	5	3.1	Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL74342	204735	0	None	-1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	345	1	2	5	3.1	Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		9894818	98925	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm00019a001
		CHEMBL279436	98925	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm00019a001
		4189	206922	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		131268	112902	27	None	26	3	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	203	1	1	5	0.1	c1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL331036	112902	27	None	26	3	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	203	1	1	5	0.1	c1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		3952	1888	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5353646	1888	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5443	1888	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		5702063	1888	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL1331786	1888	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		CHEMBL420	1888	38	None	-3	12	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
		10266032	188881	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	286	5	1	3	3.5	c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL50720	188881	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	286	5	1	3	3.5	c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		12114851	13041	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	732	7	6	6	5.0	O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1189965	13041	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	732	7	6	6	5.0	O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL539824	13041	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	732	7	6	6	5.0	O=C(NCCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		44292386	101482	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		CHEMBL297827	101482	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	296	4	1	3	3.5	C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		13123529	101863	0	None	-	1	Bovine	6.8	pKi	=	6.8	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300628	101863	0	None	-	1	Bovine	6.8	pKi	=	6.8	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		12574	2605	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		4810	2605	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		CHEMBL19236	2605	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		DB09242	2605	88	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1021/jm960012o
		3584	3777	64	None	-251	13	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		5401	3777	64	None	-251	13	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		7302	3777	64	None	-251	13	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		CHEMBL611	3777	64	None	-251	13	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		DB01162	3777	64	None	-251	13	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm970364a
		11041026	180225	48	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	162	1	2	2	0.7	NCC1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c01475
		CHEMBL4749860	180225	48	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	162	1	2	2	0.7	NCC1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c01475
		162645059	179414	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4740168	179414	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.1	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		162653032	180391	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	505	8	5	11	0.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4751862	180391	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	505	8	5	11	0.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc(Cl)cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		162654934	180591	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4754362	180591	0	None	-	1	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	485	9	5	11	0.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		9894818	98925	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL279436	98925	0	None	-83	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		10474335	194692	23	None	-52	10	Human	5.8	pKi	=	5.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		CHEMBL53325	194692	23	None	-52	10	Human	5.8	pKi	=	5.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		90644710	112729	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	3	3	4	2.1	N=C(NCc1ccco1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289529	112729	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	3	3	4	2.1	N=C(NCc1ccco1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304670	112729	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	259	3	3	4	2.1	N=C(NCc1ccco1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		44421258	84746	0	None	3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL1204386	84746	0	None	3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL222933	84746	0	None	3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	264	3	1	3	2.8	c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1	10.1021/jm0408215
		62379598	112769	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	3	3	3	1.8	CCCNC(=N)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289539	112769	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	3	3	3	1.8	CCCNC(=N)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305463	112769	3	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	3	3	3	1.8	CCCNC(=N)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		5318	15576	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	15576	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	15576	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		5353853	17986	47	None	-16	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	17986	47	None	-16	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	17986	47	None	-16	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		101333429	117076	0	None	-3890	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1	10.1021/jm00019a001
		CHEMBL3392247	117076	0	None	-3890	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1	10.1021/jm00019a001
		11186523	127511	0	None	-109	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL366164	127511	0	None	-109	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		135356876	174074	0	None	-9	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assayBinding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assay	ChEMBL	464	5	2	6	5.5	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1	10.1021/acs.jmedchem.6b00044
		CHEMBL4544251	174074	0	None	-9	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assayBinding affinity to human alpha2A receptor expressed in MDCK cells by PDSP assay	ChEMBL	464	5	2	6	5.5	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1	10.1021/acs.jmedchem.6b00044
		114697	3687	4	None	-8	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	263	1	2	3	2.7	Clc1ccc(cc1NC1=NCCN1)C(F)(F)F	10.1021/jm00020a021
		513	3687	4	None	-8	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	263	1	2	3	2.7	Clc1ccc(cc1NC1=NCCN1)C(F)(F)F	10.1021/jm00020a021
		CHEMBL101340	3687	4	None	-8	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	263	1	2	3	2.7	Clc1ccc(cc1NC1=NCCN1)C(F)(F)F	10.1021/jm00020a021
		12981869	168636	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1ccc2c(c1)C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		CHEMBL436234	168636	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1ccc2c(c1)C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		10508016	207156	0	None	-43	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	613	9	2	5	7.7	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1	10.1021/jm980077m
		CHEMBL92322	207156	0	None	-43	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	613	9	2	5	7.7	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1	10.1021/jm980077m
		132584404	143349	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	416	3	0	2	6.7	CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32	10.1016/j.bmcl.2016.10.065
		CHEMBL3897499	143349	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	416	3	0	2	6.7	CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32	10.1016/j.bmcl.2016.10.065
		135	2532	43	None	-4	58	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-4	58	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-4	58	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-4	58	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-4	58	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		44324800	206948	0	None	-5	7	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91157	206948	0	None	-5	7	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		14004040	51635	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL158371	51635	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		124	2981	47	None	-4	33	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		2032	2981	47	None	-4	33	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		4636	2981	47	None	-4	33	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		CHEMBL762	2981	47	None	-4	33	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		DB00935	2981	47	None	-4	33	Human	7.8	pKi	=	7.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
		14004040	51635	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL158371	51635	0	None	6	2	Bovine	7.8	pKi	=	7.8	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	0	2	3.5	c1ccc2c3c(oc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		15391752	182330	0	None	-7	7	Human	7.8	pKi	=	7.8	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	411	7	1	5	4.6	CC(=O)Nc1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		CHEMBL4784373	182330	0	None	-7	7	Human	7.8	pKi	=	7.8	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	411	7	1	5	4.6	CC(=O)Nc1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		44371744	50321	0	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	270	7	1	3	2.9	C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL157206	50321	0	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	270	7	1	3	2.9	C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		11360447	85001	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
		CHEMBL223829	85001	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1cccs1)C1=NCCN1	10.1021/jm0408215
		44350012	18024	0	None	6	3	Bovine	5.8	pKi	=	5.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	363	4	3	7	0.4	CC1CN=C2C(N3CCNCC3)=NC=CN21.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		CHEMBL126394	18024	0	None	6	3	Bovine	5.8	pKi	=	5.8	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	363	4	3	7	0.4	CC1CN=C2C(N3CCNCC3)=NC=CN21.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		6604117	187847	6	None	-16	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL2062340	187847	6	None	-16	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL49623	187847	6	None	-16	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		168290009	191818	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	267	1	2	5	2.0	Nc1ncc(/C=C2\CCc3c(O)cccc3C2=O)cn1	10.1016/j.ejmech.2021.113964
		CHEMBL5198566	191818	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	267	1	2	5	2.0	Nc1ncc(/C=C2\CCc3c(O)cccc3C2=O)cn1	10.1016/j.ejmech.2021.113964
		10660	14416	58	None	-43	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	-43	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		6918276	15611	7	None	-16	8	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	15611	7	None	-16	8	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		3198	205513	76	None	-19	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-19	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-19	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		11140345	204171	0	None	-1	6	Human	6.8	pKi	=	6.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70692	204171	0	None	-1	6	Human	6.8	pKi	=	6.8	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
		122442272	138348	0	None	-11	15	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	138348	0	None	-11	15	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	138348	0	None	-11	15	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		49836306	18575	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276247	18575	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		21392988	204817	4	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	156	0	0	4	-0.3	C1COC(N2CCOCC2)=N1	10.1016/0960-894X(94)85032-1
		CHEMBL75201	204817	4	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	156	0	0	4	-0.3	C1COC(N2CCOCC2)=N1	10.1016/0960-894X(94)85032-1
		4209	3163	75	None	-616	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	3163	75	None	-616	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	3163	75	None	-616	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	3163	75	None	-616	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	3163	75	None	-616	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	3163	75	None	-616	33	Rat	5.8	pKi	=	5.8	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		1547484	940	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		654	940	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9072	940	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL43064	940	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB00568	940	74	None	-5	20	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		3645619	3034	20	None	-104	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at alpha-1 adrenergic receptorBinding affinity at alpha-1 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
		975	3034	20	None	-104	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at alpha-1 adrenergic receptorBinding affinity at alpha-1 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
		CHEMBL45244	3034	20	None	-104	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at alpha-1 adrenergic receptorBinding affinity at alpha-1 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
		132060720	162489	0	None	-4	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		CHEMBL4167315	162489	0	None	-4	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		44415569	165934	0	None	-107	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL425069	165934	0	None	-107	6	Human	6.8	pKi	=	6.8	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		26987	949	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		6063	949	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		671	949	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		CHEMBL1626	949	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		DB00283	949	33	None	-158	21	Human	6.8	pKi	=	6.8	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		9838192	111312	18	None	2	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1007/s00044-004-0020-z
		CHEMBL326702	111312	18	None	2	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1007/s00044-004-0020-z
		155523897	170870	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4454147	170870	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		155556443	174484	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	406	6	0	6	3.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C(C)(C)C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4554450	174484	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	406	6	0	6	3.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(C(C)(C)C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		9838192	111312	18	None	2	5	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1021/jm030551a
		CHEMBL326702	111312	18	None	2	5	Human	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1021/jm030551a
		136680384	207655	0	None	-380	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	694	16	4	8	4.9	CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		44328799	207655	0	None	-380	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	694	16	4	8	4.9	CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		CHEMBL95290	207655	0	None	-380	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	694	16	4	8	4.9	CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		90644742	112740	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	2	2	4	1.9	c1coc(C2CN/C(=N/c3ccc4c(c3)OCO4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289550	112740	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	2	2	4	1.9	c1coc(C2CN/C(=N/c3ccc4c(c3)OCO4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304990	112740	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	2	2	4	1.9	c1coc(C2CN/C(=N/c3ccc4c(c3)OCO4)N2)c1	10.1016/j.ejmech.2014.05.057
		135	2532	43	None	-5	58	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		1796	2532	43	None	-5	58	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		4184	2532	43	None	-5	58	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		CHEMBL6437	2532	43	None	-5	58	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		DB06148	2532	43	None	-5	58	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm00366a007
		3303	2244	46	None	-251	15	Human	6.8	pKi	=	6.8	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1021/acs.jmedchem.7b00151
		5311200	2244	46	None	-251	15	Human	6.8	pKi	=	6.8	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1021/acs.jmedchem.7b00151
		CHEMBL267014	2244	46	None	-251	15	Human	6.8	pKi	=	6.8	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1021/acs.jmedchem.7b00151
		10319299	81587	0	None	-48	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	408	4	1	4	5.7	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1-c1ccccc1	10.1021/jm060262x
		CHEMBL216290	81587	0	None	-48	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	408	4	1	4	5.7	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1-c1ccccc1	10.1021/jm060262x
		10177445	166042	0	None	-32	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	4	1	4	5.2	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C(C)C	10.1021/jm060262x
		CHEMBL425622	166042	0	None	-32	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	4	1	4	5.2	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C(C)C	10.1021/jm060262x
		CHEMBL1441214	39817	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1476898	39817	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		71454275	84048	0	None	-41	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]UK 14.304 from human adrenergic alpha2A receptorDisplacement of [3H]UK 14.304 from human adrenergic alpha2A receptor	ChEMBL	293	3	1	3	3.0	CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1	10.1021/jm300975f
		CHEMBL2207493	84048	0	None	-41	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]UK 14.304 from human adrenergic alpha2A receptorDisplacement of [3H]UK 14.304 from human adrenergic alpha2A receptor	ChEMBL	293	3	1	3	3.0	CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1	10.1021/jm300975f
		11221758	84617	0	None	7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1	10.1021/jm0408215
		CHEMBL222138	84617	0	None	7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1	10.1021/jm0408215
		90644716	112717	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	233	3	4	2	1.5	N=C(NCCO)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289526	112717	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	233	3	4	2	1.5	N=C(NCCO)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304535	112717	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	233	3	4	2	1.5	N=C(NCCO)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		16725934	147423	0	None	-87	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL392992	147423	0	None	-87	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		44574077	178760	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	267	2	0	4	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL468710	178760	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	267	2	0	4	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1	10.1016/j.bmcl.2009.03.166
		136	3292	32	None	-12	15	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		223	3292	32	None	-12	15	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		643606	3292	32	None	-12	15	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		CHEMBL10347	3292	32	None	-12	15	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		3024499	175473	73	None	20	2	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccc(N2CCNCC2)n1	10.1021/jm00366a007
		CHEMBL45773	175473	73	None	20	2	Bovine	7.8	pKi	=	7.8	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccc(N2CCNCC2)n1	10.1021/jm00366a007
		11140347	204533	1	None	-2	6	Human	7.7	pKi	=	7.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL72768	204533	1	None	-2	6	Human	7.7	pKi	=	7.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		44292381	101394	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	244	2	1	3	2.7	c1ccc([C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL297228	101394	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	244	2	1	3	2.7	c1ccc([C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		25142456	82406	2	None	-89	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned adrenergic alpha 2A receptorBinding affinity to human cloned adrenergic alpha 2A receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		CHEMBL217299	82406	2	None	-89	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned adrenergic alpha 2A receptorBinding affinity to human cloned adrenergic alpha 2A receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		188249	39653	4	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		CHEMBL147463	39653	4	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		CHEMBL2022280	39653	4	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		73213195	104459	0	None	-61	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-61	12	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		164615845	185190	0	None	-1	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		CHEMBL4857492	185190	0	None	-1	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		5198	19433	54	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		CHEMBL12948	19433	54	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	nan
		68712	100338	60	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
		CHEMBL289480	100338	60	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/0960-894X(94)85032-1
		57395663	71181	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.5	CC(Oc1ccccc1C(F)(F)F)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956193	71181	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.5	CC(Oc1ccccc1C(F)(F)F)C1=NCCN1	10.1016/j.bmc.2012.01.035
		122065	189549	3	None	-3630	8	Human	5.7	pKi	=	5.7	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	380	5	1	6	1.5	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1	10.1021/jm970159v
		CHEMBL51433	189549	3	None	-3630	8	Human	5.7	pKi	=	5.7	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	380	5	1	6	1.5	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1	10.1021/jm970159v
		2247	505	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-58	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		73213195	104459	0	None	-61	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104092	104459	0	None	-61	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
		10379016	16492	2	None	-1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	281	1	1	5	0.9	Brc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		CHEMBL123566	16492	2	None	-1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	281	1	1	5	0.9	Brc1cnc(N2CCNCC2)c2nccn12	10.1021/jm00099a012
		3117	207841	103	None	-2	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	207841	103	None	-2	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		135398737	958	93	None	-26	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		38	958	93	None	-26	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		722	958	93	None	-26	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		CHEMBL42	958	93	None	-26	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		DB00363	958	93	None	-26	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm2013419
		10362866	82299	0	None	-371	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		CHEMBL217203	82299	0	None	-371	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		10474679	97177	0	None	-288	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	4.0	CN1CCN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CC1(C)C	10.1021/jm060262x
		CHEMBL268217	97177	0	None	-288	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	4.0	CN1CCN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CC1(C)C	10.1021/jm060262x
		44438168	93818	0	None	-53	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL247665	93818	0	None	-53	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		44324900	206898	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	423	6	0	7	2.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL90843	206898	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	423	6	0	7	2.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		11043720	92172	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL242265	92172	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		11043720	92172	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL242265	92172	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		44289035	100514	0	None	-977	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.4	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL291166	100514	0	None	-977	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.4	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		90644714	112770	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	4	4	3	0.7	CN(C)c1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289527	112770	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	4	4	3	0.7	CN(C)c1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305464	112770	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	4	4	3	0.7	CN(C)c1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		155538461	172401	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(C(F)(F)F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4476557	172401	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(C(F)(F)F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644718	112760	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	5	5	3	1.0	CCNc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289525	112760	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	5	5	3	1.0	CCNc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305320	112760	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	222	5	5	3	1.0	CCNc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		1353	1911	93	None	-190	83	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-190	83	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-190	83	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-190	83	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-190	83	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		16090601	82392	0	None	-208	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1c(CO)nc2ccccc2c1Nc1ccc(N2CCN(C)[C@H](C)C2)cc1	10.1021/jm060262x
		CHEMBL217254	82392	0	None	-208	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1c(CO)nc2ccccc2c1Nc1ccc(N2CCN(C)[C@H](C)C2)cc1	10.1021/jm060262x
		10873978	168486	0	None	-4677	6	Rat	5.7	pKi	=	5.7	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		CHEMBL435218	168486	0	None	-4677	6	Rat	5.7	pKi	=	5.7	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		135398737	958	93	None	-10	89	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		38	958	93	None	-10	89	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		722	958	93	None	-10	89	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		CHEMBL42	958	93	None	-10	89	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		DB00363	958	93	None	-10	89	Rat	7.7	pKi	=	7.7	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		10106205	207137	1	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
		CHEMBL92221	207137	1	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
		12981870	58120	2	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	3	2.0	C1=NCC(Cc2cc3ccccc3o2)N1	10.1021/jm001040g
		CHEMBL167644	58120	2	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	3	2.0	C1=NCC(Cc2cc3ccccc3o2)N1	10.1021/jm001040g
		10465942	13545	0	None	1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL1193821	13545	0	None	1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL545289	13545	0	None	1	3	Bovine	6.7	pKi	=	6.7	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		16090596	82291	0	None	-275	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2c(C)cccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL217177	82291	0	None	-275	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2c(C)cccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		21584368	199852	3	None	-4	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1021/acs.jmedchem.0c01475
		CHEMBL59441	199852	3	None	-4	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1021/acs.jmedchem.0c01475
		90644712	112750	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	5	4	3	1.0	CCOc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289528	112750	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	5	4	3	1.0	CCOc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305159	112750	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	223	5	4	3	1.0	CCOc1ccc(NC(=N)NCCO)cc1	10.1016/j.ejmech.2014.05.057
		135398745	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		47	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		CHEMBL715	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		DB00334	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		162672516	183122	0	None	-3	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	425	8	1	5	5.0	CC(=O)Nc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		CHEMBL4794963	183122	0	None	-3	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	425	8	1	5	5.0	CC(=O)Nc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1	10.1016/j.bmcl.2020.127506
		127036186	137414	0	None	-6	19	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3753318	137414	0	None	-6	19	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
		14004039	119561	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		CHEMBL346016	119561	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		12699315	76298	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	243	1	2	3	2.8	CC1CNC(Nc2c(Cl)cccc2Cl)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL2058631	76298	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	243	1	2	3	2.8	CC1CNC(Nc2c(Cl)cccc2Cl)=N1	10.1016/j.bmc.2012.06.008
		14004039	119561	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		CHEMBL346016	119561	3	None	5	2	Bovine	6.7	pKi	=	6.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	193	0	0	2	2.8	c1cc2c(s1)C1CCCCN1CC2	10.1021/jm00398a025
		44288874	101095	0	None	-1949	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	528	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL295001	101095	0	None	-1949	7	Human	5.7	pKi	=	5.7	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	528	7	2	4	4.2	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		11034737	204528	0	None	2	6	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	289	4	2	4	2.8	CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL72724	204528	0	None	2	6	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	289	4	2	4	2.8	CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
		14004032	119834	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL348538	119834	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		185076	187090	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm960359r
		CHEMBL49137	187090	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm960359r
		185076	187090	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm9605142
		CHEMBL49137	187090	5	None	2	7	Human	8.7	pKi	=	8.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1021/jm9605142
		2142	3096	58	None	1	36	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		4920903	3096	58	None	1	36	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		502	3096	58	None	1	36	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		5775	3096	58	None	1	36	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		CHEMBL597	3096	58	None	1	36	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		DB00692	3096	58	None	1	36	Bovine	8.7	pKi	=	8.7	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00366a022
		2142	3096	58	None	-2	36	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		4920903	3096	58	None	-2	36	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		502	3096	58	None	-2	36	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		5775	3096	58	None	-2	36	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		CHEMBL597	3096	58	None	-2	36	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		DB00692	3096	58	None	-2	36	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
		124	2981	47	None	-4	33	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		2032	2981	47	None	-4	33	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		4636	2981	47	None	-4	33	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		CHEMBL762	2981	47	None	-4	33	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		DB00935	2981	47	None	-4	33	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/j.bmcl.2013.12.024
		102	4127	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		3659	4127	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		8969	4127	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		CHEMBL15245	4127	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		DB01392	4127	48	None	-5	49	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
		218362	204800	5	None	-1	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
		CHEMBL75030	204800	5	None	-1	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	216	1	1	3	2.0	c1ccc2c(c1)CCCC2NC1=NCCO1	10.1016/0960-894X(94)85032-1
		73453	29616	24	None	-3	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	29616	24	None	-3	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		135440165	78945	0	None	-23	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112985	78945	0	None	-23	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		136019934	144530	0	None	-7	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		CHEMBL390718	144530	0	None	-7	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		9928332	97180	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/s0960-894x(03)00525-0
		CHEMBL268258	97180	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/s0960-894x(03)00525-0
		9928332	97180	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1021/jm049619s
		CHEMBL268258	97180	5	None	-1	9	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1021/jm049619s
		10176567	102800	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		CHEMBL30534	102800	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		44324765	111568	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328114	111568	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		10176567	102800	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		CHEMBL30534	102800	3	None	10	4	Rat	8.6	pKi	=	8.6	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		44324765	111568	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		CHEMBL328114	111568	0	None	-2	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1021/jm049619s
		2142	3096	58	None	-2	36	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		4920903	3096	58	None	-2	36	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		502	3096	58	None	-2	36	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		5775	3096	58	None	-2	36	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		CHEMBL597	3096	58	None	-2	36	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		DB00692	3096	58	None	-2	36	Human	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		11959098	179536	56	None	79	2	Bovine	8.6	pKi	=	8.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	0	3	1.5	CN1CCN(c2ncccc2Cl)CC1	10.1021/jm00366a007
		CHEMBL47415	179536	56	None	79	2	Bovine	8.6	pKi	=	8.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	0	3	1.5	CN1CCN(c2ncccc2Cl)CC1	10.1021/jm00366a007
		2435	722	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		395	722	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		520	722	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		5386	722	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		CHEMBL844	722	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		DB00484	722	100	None	-2	12	Human	8.6	pKi	=	8.6	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1021/jm9605142
		3038495	708	37	None	-1	19	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1016/j.bmcl.2010.07.002
		7625	708	37	None	-1	19	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1016/j.bmcl.2010.07.002
		CHEMBL25236	708	37	None	-1	19	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1016/j.bmcl.2010.07.002
		46934427	15628	0	None	3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	481	11	1	5	4.5	COc1ccccc1N1CCN(CCCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221594	15628	0	None	3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	481	11	1	5	4.5	COc1ccccc1N1CCN(CCCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		12203911	188283	22	None	54	2	Bovine	8.5	pKi	=	8.5	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	255	1	0	3	1.6	CN1CCN(c2ncccc2Br)CC1	10.1021/jm00366a007
		CHEMBL50017	188283	22	None	54	2	Bovine	8.5	pKi	=	8.5	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	255	1	0	3	1.6	CN1CCN(c2ncccc2Br)CC1	10.1021/jm00366a007
		9816063	103074	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		CHEMBL30739	103074	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		2216	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		229	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		7117	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		CHEMBL647	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		DB00964	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	10.1021/jm960359r
		44330584	108119	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL319573	108119	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		10480357	208218	0	None	-9	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL98541	208218	0	None	-9	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		9816063	103074	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		CHEMBL30739	103074	0	None	4	6	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		44314198	104412	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
		CHEMBL310335	104412	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCCC1NC1=NCCO1	10.1016/0960-894X(94)85032-1
		9815707	101469	0	None	1	3	Human	8.5	pKi	=	8.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
		CHEMBL297752	101469	0	None	1	3	Human	8.5	pKi	=	8.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	210	3	1	3	2.3	CCC[C@H]1CCCC[C@@H]1NC1=NCCO1	10.1021/jm9905256
		134551	358	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	358	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	358	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	358	27	None	-3	21	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		11224953	78934	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	459	6	1	5	3.3	CCNC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112973	78934	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	459	6	1	5	3.3	CCNC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		135499867	78941	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	388	5	1	5	3.2	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4NC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL2112981	78941	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	388	5	1	5	3.2	C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4NC[C@H]32)CC1	10.1021/jm049619s
		1816	2540	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		4205	2540	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		7241	2540	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		CHEMBL654	2540	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		DB00370	2540	102	None	-51	18	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		49836303	18572	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276220	18572	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		2803	955	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		516	955	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		704	955	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		CHEMBL134	955	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		DB00575	955	58	None	-1	19	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.ejmech.2014.05.057
		49836303	18572	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276220	18572	1	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		10848826	188880	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	258	3	1	3	2.8	c1ccc(C[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL50719	188880	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	258	3	1	3	2.8	c1ccc(C[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL508338	188966	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		14004032	119834	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL348538	119834	2	None	1	2	Bovine	5.7	pKi	=	5.7	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	188	0	0	2	2.2	c1cnc2c(c1)CCN1CCCCC21	10.1021/jm00398a025
		44415672	80174	0	None	-1659	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213492	80174	0	None	-1659	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11057	176149	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	176149	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	176149	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	176149	23	None	-1	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		44574106	178426	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	317	3	1	3	3.3	CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL466012	178426	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	317	3	1	3	3.3	CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		135398745	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	-93	65	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		1201549	597	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-33	20	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		11750482	147421	0	None	-25	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL392991	147421	0	None	-25	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		12909388	61056	0	None	-14	2	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	303	0	0	3	3.4	CN1CCC(=C2c3cc(C#N)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL176365	61056	0	None	-14	2	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	303	0	0	3	3.4	CN1CCC(=C2c3cc(C#N)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		3598	187821	76	None	-2	7	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	187821	76	None	-2	7	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		44579187	189679	0	None	-263	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
		CHEMBL515331	189679	0	None	-263	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	513	8	1	8	3.3	N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1	10.1016/j.bmcl.2008.08.055
		132060733	162124	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	294	3	0	3	3.0	c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1	10.1016/j.ejmech.2018.02.024
		CHEMBL4161503	162124	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	294	3	0	3	3.0	c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1	10.1016/j.ejmech.2018.02.024
		11801828	206544	0	None	-128	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	606	9	3	6	5.0	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		CHEMBL88628	206544	0	None	-128	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	606	9	3	6	5.0	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		124	2981	47	None	-16	33	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		2032	2981	47	None	-16	33	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		4636	2981	47	None	-16	33	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		CHEMBL762	2981	47	None	-16	33	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		DB00935	2981	47	None	-16	33	Pig	7.7	pKi	=	7.7	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm00018a001
		123920	100154	41	None	309	2	Rat	7.7	pKi	=	7.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1021/jm0205752
		CHEMBL287837	100154	41	None	309	2	Rat	7.7	pKi	=	7.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1021/jm0205752
		4209	3163	75	None	-3235	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		4893	3163	75	None	-3235	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		503	3163	75	None	-3235	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		5385	3163	75	None	-3235	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		CHEMBL2	3163	75	None	-3235	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		DB00457	3163	75	None	-3235	33	Human	6.7	pKi	=	6.7	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00010a001
		13141182	130893	1	None	-10	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	354	0	0	2	4.7	CN1CCC(=C2c3cc(Br)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368578	130893	1	None	-10	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	354	0	0	2	4.7	CN1CCC(=C2c3cc(Br)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		10490084	204958	1	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	237	2	2	2	2.9	Brc1ccccc1Nc1ncc[nH]1	10.1021/jm9605142
		CHEMBL76457	204958	1	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	237	2	2	2	2.9	Brc1ccccc1Nc1ncc[nH]1	10.1021/jm9605142
		44574045	189286	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	260	2	0	2	3.9	c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.166
		CHEMBL512062	189286	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	260	2	0	2	3.9	c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.166
		50878551	90745	61	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL2391541	90745	61	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
		24906197	187666	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	323	7	1	5	3.0	CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1	10.1021/jm800250z
		CHEMBL495097	187666	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	323	7	1	5	3.0	CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1	10.1021/jm800250z
		90644704	112715	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	4	2	3	2.1	CN(C)c1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289532	112715	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	4	2	3	2.1	CN(C)c1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304530	112715	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	258	4	2	3	2.1	CN(C)c1ccc(/N=C(/N)NCc2ccco2)cc1	10.1016/j.ejmech.2014.05.057
		4209	3163	75	None	-3235	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	3163	75	None	-3235	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	3163	75	None	-3235	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	3163	75	None	-3235	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	3163	75	None	-3235	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	3163	75	None	-3235	33	Human	5.7	pKi	=	5.7	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		10793665	106952	0	None	-1202	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	597	9	2	5	7.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1	10.1021/jm980077m
		CHEMBL314960	106952	0	None	-1202	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	597	9	2	5	7.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1	10.1021/jm980077m
		1549008	205680	85	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		CHEMBL822	205680	85	None	-	1	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	nan
		44438161	147141	0	None	-22	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL392771	147141	0	None	-22	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	10.1016/j.bmcl.2006.12.094
		2520	204008	70	None	-6	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL1280	204008	70	None	-6	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		CHEMBL6966	204008	70	None	-6	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
		12488	1657	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-6	23	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		11098175	204170	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
		CHEMBL70691	204170	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
		10841190	107042	0	None	-309	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	2	6	6.5	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1	10.1021/jm980077m
		CHEMBL315538	107042	0	None	-309	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	2	6	6.5	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1	10.1021/jm980077m
		90644740	112730	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	4	3	3	2.6	CCNc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289549	112730	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	4	3	3	2.6	CCNc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304693	112730	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	270	4	3	3	2.6	CCNc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL1200633	208600	3	None	-7	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		133	2496	52	None	-23	42	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-23	42	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-23	42	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-23	42	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-23	42	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		44330679	208274	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	464	7	0	8	2.9	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccnc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL98889	208274	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	464	7	0	8	2.9	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccnc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44324859	111612	0	None	-4	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	461	6	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CC4=Cc5ccccc5C4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328377	111612	0	None	-4	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	461	6	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CC4=Cc5ccccc5C4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44549156	18570	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276218	18570	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		57345626	71180	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1021/ml400232p
		CHEMBL1956192	71180	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1021/ml400232p
		57345626	71180	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956192	71180	2	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	3	1	3	2.2	CC(Oc1ccccc1Br)C1=NCCN1	10.1016/j.bmc.2012.01.035
		45487956	198367	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	3	1	3	2.6	CC(OC1=NCCN1)c1ccccc1C1CC1	10.1021/jm901262f
		CHEMBL576623	198367	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	3	1	3	2.6	CC(OC1=NCCN1)c1ccccc1C1CC1	10.1021/jm901262f
		44549156	18570	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276218	18570	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	CC(Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		11347303	111380	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2	10.1021/jm030551a
		CHEMBL327116	111380	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	4	2	3	2.6	CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2	10.1021/jm030551a
		44579185	181814	1	None	-28	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		CHEMBL477816	181814	1	None	-28	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		5288606	97184	26	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	259	0	1	1	1.9	Ic1ccc2c(c1)CNCC2	10.1021/jm0205752
		CHEMBL26828	97184	26	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	259	0	1	1	1.9	Ic1ccc2c(c1)CNCC2	10.1021/jm0205752
		16090602	82448	0	None	-239	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	362	4	2	5	3.6	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1C	10.1021/jm060262x
		CHEMBL217542	82448	0	None	-239	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	362	4	2	5	3.6	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1C	10.1021/jm060262x
		164618319	184593	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	340	2	1	4	2.1	CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4848838	184593	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	340	2	1	4	2.1	CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		10132386	97098	2	None	-63	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C	10.1021/jm060262x
		CHEMBL267464	97098	2	None	-63	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	346	3	1	4	4.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1C	10.1021/jm060262x
		155566702	175906	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	472	9	0	6	4.2	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CCc3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4587003	175906	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	472	9	0	6	4.2	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CCc3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		90644722	112714	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	4	3	2	3.5	CCOc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289523	112714	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	4	3	2	3.5	CCOc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304529	112714	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	4	3	2	3.5	CCOc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		49783209	17609	0	None	-1122	26	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human adrenergic alpha2A receptorBinding affinity to human adrenergic alpha2A receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	17609	0	None	-1122	26	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human adrenergic alpha2A receptorBinding affinity to human adrenergic alpha2A receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		9906978	42711	2	None	-165	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL150161	42711	2	None	-165	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		9837106	104157	2	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		CHEMBL30955	104157	2	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		9837106	104157	2	None	8	4	Rat	6.7	pKi	=	6.7	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		CHEMBL30955	104157	2	None	8	4	Rat	6.7	pKi	=	6.7	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		1443	2028	34	None	-23	10	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		33625	2028	34	None	-23	10	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		501	2028	34	None	-23	10	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		CHEMBL279516	2028	34	None	-23	10	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		DB08950	2028	34	None	-23	10	Human	5.7	pKi	=	5.7	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	10.1021/jm00018a001
		2162	41514	100	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		CHEMBL1491	41514	100	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	nan
		12909385	60429	1	None	-7	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	276	0	0	2	4.0	CN1CCC(=C2c3ccccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL175154	60429	1	None	-7	2	Bovine	6.7	pKi	=	6.7	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	276	0	0	2	4.0	CN1CCC(=C2c3ccccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		135453290	133606	33	None	-758	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		CHEMBL371300	133606	33	None	-758	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cellsDisplacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
		21509921	104458	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		44288945	168915	0	None	-575	7	Human	6.6	pKi	=	6.6	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	485	7	2	3	4.4	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL43860	168915	0	None	-575	7	Human	6.6	pKi	=	6.6	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	485	7	2	3	4.4	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		21509921	104458	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104091	104458	0	None	-22	24	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
		3080926	155595	21	None	10	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/acs.jmedchem.9b02080
		CHEMBL404505	155595	21	None	10	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/acs.jmedchem.9b02080
		44330571	163999	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL420830	163999	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		44330571	163999	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL420830	163999	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C\c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		9883506	70564	0	None	-1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	282	3	3	5	2.3	Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		CHEMBL194849	70564	0	None	-1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	282	3	3	5	2.3	Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		44371745	49289	0	None	11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	3	2.0	CCc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL156336	49289	0	None	11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	218	4	1	3	2.0	CCc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		13123527	101790	3	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300053	101790	3	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	189	3	2	3	1.4	Cc1ccc(NCC2=NCCN2)cc1	10.1021/jm00366a022
		13141184	165890	0	None	-17	2	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	376	1	0	3	5.6	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL424967	165890	0	None	-17	2	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	376	1	0	3	5.6	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		11198145	9815	2	None	-85	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL113830	9815	2	None	-85	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		16090597	141470	0	None	-5	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1nc2c(C)ccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL384318	141470	0	None	-5	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1nc2c(C)ccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		44328920	108641	0	None	-199	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	705	14	3	7	5.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL320736	108641	0	None	-199	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	705	14	3	7	5.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1	10.1016/s0960-894x(99)00484-9
		44325028	206971	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cccc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91297	206971	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cccc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44325079	207185	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	437	7	0	7	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL92496	207185	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	437	7	0	7	2.7	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		90644732	112718	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	1	2	3	1.0	CC1CN/C(=N/c2ccc3c(c2)OCO3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289545	112718	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	1	2	3	1.0	CC1CN/C(=N/c2ccc3c(c2)OCO3)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304536	112718	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	219	1	2	3	1.0	CC1CN/C(=N/c2ccc3c(c2)OCO3)N1	10.1016/j.ejmech.2014.05.057
		11080	29085	79	None	1	6	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	29085	79	None	1	6	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL4549667	213998	5	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000720a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000720a ADRA2A	ChEMBL		None	None	None		CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21	10.6019/CHEMBL5212743
		CHEMBL4777443	214046	0	None	-11	14	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a ADRA2A	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
		24906241	192817	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		CHEMBL522151	192817	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		24906200	193156	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		CHEMBL523048	193156	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	328	5	1	3	4.5	c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		135398737	958	93	None	-26	89	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		38	958	93	None	-26	89	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		722	958	93	None	-26	89	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		CHEMBL42	958	93	None	-26	89	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		DB00363	958	93	None	-26	89	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		126225	94976	5	None	-10	8	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	263	1	0	2	4.2	C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		CHEMBL25467	94976	5	None	-10	8	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	263	1	0	2	4.2	C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		45487089	197640	0	None	10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	204	2	1	3	2.0	Cc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		CHEMBL570863	197640	0	None	10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	204	2	1	3	2.0	Cc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		10082076	13860	0	None	9	3	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1195953	13860	0	None	9	3	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL555637	13860	0	None	9	3	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		12841592	113494	2	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	237	1	1	5	0.8	Clc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL331981	113494	2	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	237	1	1	5	0.8	Clc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL538788	113494	2	None	-	1	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	237	1	1	5	0.8	Clc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		9809007	172564	8	None	-1905	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		CHEMBL448620	172564	8	None	-1905	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1016/s0960-894x(99)00484-9
		9884781	38674	1	None	1	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	350	3	0	4	3.0	c1ccc2c(c1)CC(CN1CCN(c3ccc4c(c3)OCCO4)CC1)C2	10.1021/acs.jmedchem.7b00151
		CHEMBL146556	38674	1	None	1	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	350	3	0	4	3.0	c1ccc2c(c1)CC(CN1CCN(c3ccc4c(c3)OCCO4)CC1)C2	10.1021/acs.jmedchem.7b00151
		11624518	200343	3	None	-18	6	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	352	4	0	4	3.8	Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1	10.1016/j.ejmech.2012.08.011
		CHEMBL597601	200343	3	None	-18	6	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	352	4	0	4	3.8	Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1	10.1016/j.ejmech.2012.08.011
		415628	208192	95	None	-2	5	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	196	1	1	2	1.8	Clc1ccccc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL9841	208192	95	None	-2	5	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	196	1	1	2	1.8	Clc1ccccc1N1CCNCC1	10.1021/jm00366a007
		2389	3331	118	None	-37	67	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		5073	3331	118	None	-37	67	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		96	3331	118	None	-37	67	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		CHEMBL85	3331	118	None	-37	67	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		DB00734	3331	118	None	-37	67	Rat	7.6	pKi	=	7.6	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		10220232	99721	6	None	1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm990569e
		CHEMBL284795	99721	6	None	1	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm990569e
		6761	67799	19	None	-6	18	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-6	18	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		44324765	111568	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL328114	111568	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		10220232	99721	6	None	-1	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm000128r
		CHEMBL284795	99721	6	None	-1	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	230	1	1	2	3.5	Cc1sc(C)c2c1CCC=C2c1c[nH]cn1	10.1021/jm000128r
		23292293	58167	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	244	2	1	2	3.0	Clc1cccc2ccc(CC3CN=CN3)cc12	10.1021/jm001040g
		CHEMBL168168	58167	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	244	2	1	2	3.0	Clc1cccc2ccc(CC3CN=CN3)cc12	10.1021/jm001040g
		44314200	102952	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
		CHEMBL306377	102952	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	230	1	1	3	2.4	c1ccc2c(c1)CCCC2NC1=NCCCO1	10.1016/0960-894X(94)85032-1
		11948707	166167	0	None	-616	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity to alpha 2A adrenergic receptor by radioligand binding assayBinding affinity to alpha 2A adrenergic receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		CHEMBL426317	166167	0	None	-616	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity to alpha 2A adrenergic receptor by radioligand binding assayBinding affinity to alpha 2A adrenergic receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
		11393666	192986	0	None	-6456	19	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	192986	0	None	-6456	19	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	192986	0	None	-6456	19	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		44401194	71295	0	None	-33	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL195706	71295	0	None	-33	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		9815610	99933	19	None	-13	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		CHEMBL286246	99933	19	None	-13	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm990569e
		9815610	99933	19	None	13	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		CHEMBL286246	99933	19	None	13	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2ccsc2CC1	10.1021/jm000128r
		5280953	97362	109	None	-3	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
		CHEMBL269538	97362	109	None	-3	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards alpha-2A-Adrenergic receptorBinding affinity towards alpha-2A-Adrenergic receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
		1752	45761	59	None	-2	5	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		CHEMBL153062	45761	59	None	-2	5	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		44438152	93608	0	None	-134	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	10.1016/j.bmcl.2006.12.094
		CHEMBL246639	93608	0	None	-134	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	10.1016/j.bmcl.2006.12.094
		2286	3183	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-13	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		24906242	187247	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2c(cccc2-c2ccccc2)O1	10.1021/jm800250z
		CHEMBL492647	187247	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	310	3	1	5	2.5	COC1(C2=NCCN2)COc2c(cccc2-c2ccccc2)O1	10.1021/jm800250z
		10073773	161123	16	None	-1288	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 minsDisplacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 mins	ChEMBL	477	5	0	6	3.4	COc1ccc2c(c1)c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccccc1Br	10.1021/acs.jmedchem.6b01662
		CHEMBL4082473	161123	16	None	-1288	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 minsDisplacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 mins	ChEMBL	477	5	0	6	3.4	COc1ccc2c(c1)c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccccc1Br	10.1021/acs.jmedchem.6b01662
		CHEMBL4117187	161123	16	None	-1288	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 minsDisplacement of [3H] MK-912 from human adrenergic alpha 2A receptor expressed in HT29 cells after 60 mins	ChEMBL	477	5	0	6	3.4	COc1ccc2c(c1)c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccccc1Br	10.1021/acs.jmedchem.6b01662
		10042547	76301	5	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	334	1	1	2	3.9	CC1CCC(Nc2ccc(I)cc2Cl)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL2058635	76301	5	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	334	1	1	2	3.9	CC1CCC(Nc2ccc(I)cc2Cl)=N1	10.1016/j.bmc.2012.06.008
		155546767	173639	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	456	8	0	7	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4534152	173639	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	456	8	0	7	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(OC)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL1458880	37850	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		3778834	101320	78	None	144	2	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	208	2	1	5	0.4	O=[N+]([O-])c1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL296653	101320	78	None	144	2	Bovine	7.6	pKi	=	7.6	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	208	2	1	5	0.4	O=[N+]([O-])c1cccnc1N1CCNCC1	10.1021/jm00366a007
		44324725	206817	0	None	-13	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	451	8	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL90419	206817	0	None	-13	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	451	8	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		12114850	13248	0	None	57	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	704	5	6	6	4.2	O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1191424	13248	0	None	57	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	704	5	6	6	4.2	O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL542520	13248	0	None	57	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	704	5	6	6	4.2	O=C(NCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		44269122	98109	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm800250z
		CHEMBL273485	98109	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm800250z
		45487144	197701	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.7	CC(OC1=NCCN1)c1ccccc1	10.1021/jm901262f
		CHEMBL571314	197701	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.7	CC(OC1=NCCN1)c1ccccc1	10.1021/jm901262f
		44269122	98109	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL273485	98109	2	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	190	3	1	3	1.5	CC(Oc1ccccc1)C1=NCCN1	10.1021/jm100977d
		146025727	171685	0	None	-97	27	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	171685	0	None	-97	27	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		90644746	112722	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	265	2	3	1	4.0	N=C(Nc1ccccc1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289521	112722	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	265	2	3	1	4.0	N=C(Nc1ccccc1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304553	112722	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	265	2	3	1	4.0	N=C(Nc1ccccc1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		90644734	112719	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	4	2	3	2.6	CCOc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289546	112719	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	4	2	3	2.6	CCOc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304537	112719	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	271	4	2	3	2.6	CCOc1ccc(/N=C2/NCC(c3ccco3)N2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL4576555	214017	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		44312198	204589	0	None	1	4	Human	4.6	pKi	=	4.6	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	292	1	1	5	2.2	Brc1c(NC2=NCCO2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL73164	204589	0	None	1	4	Human	4.6	pKi	=	4.6	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	292	1	1	5	2.2	Brc1c(NC2=NCCO2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL4576555	214017	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		CHEMBL4576555	214017	5	None	-2	19	Human	5.6	pKi	=	5.6	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a ADRA2ASelectivity interaction (GPCR panel (PDSP screen)) EUB0000705a ADRA2A	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
		9926143	113526	1	None	-467	4	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptorCompound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptor	ChEMBL	294	6	2	4	3.0	O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1	10.1021/jm990266k
		CHEMBL332154	113526	1	None	-467	4	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptorCompound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptor	ChEMBL	294	6	2	4	3.0	O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1	10.1021/jm990266k
		44401041	70487	0	None	-63	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL194659	70487	0	None	-63	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		3080926	155595	21	None	10	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/ml400232p
		CHEMBL404505	155595	21	None	10	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	186	1	1	3	1.8	c1ccc2oc(C3=NCCN3)cc2c1	10.1021/ml400232p
		44579186	181976	0	None	-8	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	474	8	1	7	3.1	O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		CHEMBL478026	181976	0	None	-8	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	474	8	1	7	3.1	O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		9815633	99635	3	None	-6	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		CHEMBL284213	99635	3	None	-6	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm990569e
		9815633	99635	3	None	6	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		CHEMBL284213	99635	3	None	6	6	Rat	7.6	pKi	=	7.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	204	1	1	2	2.9	c1nc(C2CCCc3sccc32)c[nH]1	10.1021/jm000128r
		11346584	136984	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL374584	136984	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm061487a
		11346584	136984	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL374584	136984	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm0408215
		11346584	136984	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL374584	136984	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		10266538	116971	2	None	1	2	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2ncc(Br)n3ccnc23)CC1	10.1021/jm00099a012
		CHEMBL338704	116971	2	None	1	2	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	295	1	0	5	1.2	CN1CCN(c2ncc(Br)n3ccnc23)CC1	10.1021/jm00099a012
		1971	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		9828476	206924	0	None	-1202	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	532	9	2	7	5.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL91022	206924	0	None	-1202	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	532	9	2	7	5.2	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		162265	202274	22	None	-12	43	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	10.1021/jm030551a
		4786	202274	22	None	-12	43	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	10.1021/jm030551a
		CHEMBL61006	202274	22	None	-12	43	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	10.1021/jm030551a
		73346042	91834	5	None	-27542	17	Human	5.6	pKi	=	5.6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		CHEMBL2413153	91834	5	None	-27542	17	Human	5.6	pKi	=	5.6	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
		4211	57822	83	None	-1	4	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		CHEMBL1670	57822	83	None	-1	4	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
		1028	291	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		139148732	291	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		479	291	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		5816	291	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		CHEMBL679	291	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		DB00668	291	71	None	-48	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	nan
		10176567	102800	3	None	-10	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		CHEMBL30534	102800	3	None	-10	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm990569e
		10176567	102800	3	None	10	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		CHEMBL30534	102800	3	None	10	4	Rat	6.6	pKi	=	6.6	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	1	1	2	3.3	c1cc(-c2c[nH]cn2)c2ccsc2c1	10.1021/jm000128r
		126720252	164675	0	None	12	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4216870	164675	0	None	12	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		16655023	107441	2	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	107441	2	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		44292232	101321	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		CHEMBL296660	101321	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	222	3	1	3	2.2	CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1	10.1021/jm9905256
		2389	3331	118	None	-77	67	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		5073	3331	118	None	-77	67	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		96	3331	118	None	-77	67	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		CHEMBL85	3331	118	None	-77	67	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		DB00734	3331	118	None	-77	67	Human	7.6	pKi	=	7.6	Binding	Binding affinity to alpha2 adrenergic receptor (unknown origin)Binding affinity to alpha2 adrenergic receptor (unknown origin)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2020.127506
		57345625	71179	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	224	3	1	3	2.1	CC(Oc1ccccc1Cl)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956191	71179	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	224	3	1	3	2.1	CC(Oc1ccccc1Cl)C1=NCCN1	10.1016/j.bmc.2012.01.035
		44574105	178808	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	305	5	1	4	1.3	CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
		CHEMBL469127	178808	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	305	5	1	4	1.3	CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
		24906202	187217	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		CHEMBL492444	187217	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		11380133	169367	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccncc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL442045	169367	0	None	5	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	1	4	2.5	CC(Oc1ccccc1-c1ccncc1)C1=NCCN1	10.1021/jm0408215
		44456400	12834	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	12834	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	12834	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	12834	0	None	-1	10	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		13091268	78224	0	None	-3090	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL210578	78224	0	None	-3090	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	401	6	1	3	5.0	O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		24906159	187405	12	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
		CHEMBL493675	187405	12	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	233	4	2	5	1.3	CC(Oc1ccccc1/C=N/O)C1=NCCN1	10.1021/jm800250z
		11203101	71683	0	None	-44	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	515	7	3	5	4.1	O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1	10.1016/j.bmcl.2005.03.116
		CHEMBL196451	71683	0	None	-44	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2a adrenergic receptorIn vitro binding affinity towards alpha-2a adrenergic receptor	ChEMBL	515	7	3	5	4.1	O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1	10.1016/j.bmcl.2005.03.116
		11811395	204701	0	None	-2	4	Human	5.5	pKi	=	5.5	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	281	5	2	5	1.3	CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL74071	204701	0	None	-2	4	Human	5.5	pKi	=	5.5	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	281	5	2	5	1.3	CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		11777109	116967	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	254	0	1	2	2.9	Clc1cc(Cl)c2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL338683	116967	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	254	0	1	2	2.9	Clc1cc(Cl)c2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		9837106	104157	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		CHEMBL30955	104157	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm990569e
		44330427	163375	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL419336	163375	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		9837106	104157	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		CHEMBL30955	104157	2	None	8	4	Rat	8.5	pKi	=	8.5	Binding	In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineIn vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidine	ChEMBL	202	1	1	2	2.8	C1=C(c2c[nH]cn2)c2sccc2CC1	10.1021/jm000128r
		102	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		3659	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		8969	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		CHEMBL15245	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		DB01392	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 minsDisplacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1016/j.bmcl.2013.01.025
		16655023	107441	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	107441	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		102	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		3659	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		8969	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		CHEMBL15245	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		DB01392	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm990277d
		102	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		3659	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		8969	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		CHEMBL15245	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		DB01392	4127	48	None	-5	49	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/acs.jmedchem.9b01465
		12576	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		71310	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		CHEMBL353972	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		DB11481	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	10.1021/jm001040g
		10585356	120610	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	1	1	2	2.2	C1=NC[C@@H](C2C[C@@]23CCc2ccccc2C3)N1	10.1021/jm001040g
		135433755	120610	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	1	1	2	2.2	C1=NC[C@@H](C2C[C@@]23CCc2ccccc2C3)N1	10.1021/jm001040g
		CHEMBL354611	120610	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	1	1	2	2.2	C1=NC[C@@H](C2C[C@@]23CCc2ccccc2C3)N1	10.1021/jm001040g
		78114676	169841	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	402	6	0	6	3.3	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4439953	169841	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	402	6	0	6	3.3	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		13123529	101863	0	None	-	1	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		CHEMBL300628	101863	0	None	-	1	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	203	3	1	3	1.4	Cc1ccc(N(C)CC2=NCCN2)cc1	10.1021/jm00366a022
		49781006	17240	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	240	3	1	2	2.9	CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256565	17240	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	240	3	1	2	2.9	CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		136	3292	32	None	-12	15	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		223	3292	32	None	-12	15	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		643606	3292	32	None	-12	15	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		CHEMBL10347	3292	32	None	-12	15	Bovine	8.5	pKi	=	8.5	Binding	Compound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]rauwolscine to Alpha-2 adrenergic receptor in bovine pineal	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		16655023	107441	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL318235	107441	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmc.2007.03.053
		16655023	107441	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL318235	107441	2	None	-5	7	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	481	7	0	7	3.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		499	4077	18	None	-13	14	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		5685	4077	18	None	-13	14	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		CHEMBL25554	4077	18	None	-13	14	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		2389	3331	118	None	-77	67	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-77	67	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-77	67	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-77	67	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-77	67	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		2803	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		516	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		704	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		CHEMBL134	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		DB00575	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960012o
		2803	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		516	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		704	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		CHEMBL134	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		DB00575	955	58	None	-1	19	Human	8.4	pKi	=	8.4	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm960359r
		49781887	17144	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		CHEMBL1255617	17144	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	222	1	1	1	2.9	c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1	10.1021/jm1006269
		9990389	120432	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	2	1.8	C1=NCC(CC2Cc3ccccc3C2)N1	10.1021/jm001040g
		CHEMBL353843	120432	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	200	2	1	2	1.8	C1=NCC(CC2Cc3ccccc3C2)N1	10.1021/jm001040g
		49781007	17241	0	None	-2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	4	1	2	3.3	CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256566	17241	0	None	-2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	4	1	2	3.3	CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		240	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		2769	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		44279790	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		660	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		CHEMBL1729	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		CHEMBL560739	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		DB00604	944	43	None	-3	24	Rat	7.5	pKi	=	7.5	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00013a009
		44324972	163372	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL419316	163372	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	463	7	0	7	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		9971924	184226	0	None	3	3	Human	7.5	pKi	=	7.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		CHEMBL48341	184226	0	None	3	3	Human	7.5	pKi	=	7.5	Binding	Inhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscineInhibitory constant against human Alpha-2A adrenergic receptor expressed in LM(tk-) cells using [3H]rauwolscine	ChEMBL	298	5	1	3	3.4	c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1	10.1021/jm9905256
		13123531	188241	0	None	-	1	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		CHEMBL49953	188241	0	None	-	1	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	217	4	1	3	1.8	CCN(CC1=NCCN1)c1ccc(C)cc1	10.1021/jm00366a022
		9953974	77833	0	None	-24	3	Human	5.5	pKi	=	5.5	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		CHEMBL2092927	77833	0	None	-24	3	Human	5.5	pKi	=	5.5	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		7059292	76300	7	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	1	1	2	2.9	Clc1ccccc1NC1=NCCC1	10.1016/j.bmc.2012.06.008
		CHEMBL2058633	76300	7	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	1	1	2	2.9	Clc1ccccc1NC1=NCCC1	10.1016/j.bmc.2012.06.008
		9894818	98925	0	None	-83	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL279436	98925	0	None	-83	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		44401042	124829	0	None	-81	9	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL364270	124829	0	None	-81	9	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		11225732	93657	0	None	-16	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL246852	93657	0	None	-16	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		10198248	187449	40	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	213	1	2	5	1.0	c1cnc2cc(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		CHEMBL49395	187449	40	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	213	1	2	5	1.0	c1cnc2cc(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		11199581	136559	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1	10.1021/jm0408215
		CHEMBL373830	136559	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1	10.1021/jm0408215
		9944467	9251	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	2	2	2	3.4	O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F	10.1021/jm030551a
		CHEMBL110751	9251	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	2	2	2	3.4	O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F	10.1021/jm030551a
		9794524	204843	2	None	10	3	Human	7.5	pKi	=	7.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	225	2	2	4	2.4	Cc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		CHEMBL75491	204843	2	None	10	3	Human	7.5	pKi	=	7.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	225	2	2	4	2.4	Cc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		10946567	16469	0	None	-25	6	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	265	1	0	2	4.1	CCc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		CHEMBL123448	16469	0	None	-25	6	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	265	1	0	2	4.1	CCc1sc2ccc(Cl)c3c2c1CN(C)CC3	10.1021/jm00019a001
		15463615	120364	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	246	2	1	2	3.1	Clc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		CHEMBL353200	120364	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	246	2	1	2	3.1	Clc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		44371864	51141	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL157955	51141	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	3	2.6	CCc1cccc(CC)c1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		13141183	161963	1	None	-15	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	310	0	0	2	4.6	CN1CCC(=C2c3cc(Cl)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL415761	161963	1	None	-15	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	310	0	0	2	4.6	CN1CCC(=C2c3cc(Cl)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		10045088	80588	0	None	-407	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1CO	10.1021/jm060262x
		CHEMBL214996	80588	0	None	-407	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	376	4	2	5	3.9	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1CO	10.1021/jm060262x
		16090631	82391	0	None	-630	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.5	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C(C)O	10.1021/jm060262x
		CHEMBL217253	82391	0	None	-630	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	4	2	5	4.5	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C(C)O	10.1021/jm060262x
		10632290	204746	5	None	2	3	Human	5.5	pKi	=	5.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	211	2	2	4	2.1	c1c[nH]c(Nc2ccc3nccnc3c2)n1	10.1021/jm9605142
		CHEMBL74449	204746	5	None	2	3	Human	5.5	pKi	=	5.5	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	211	2	2	4	2.1	c1c[nH]c(Nc2ccc3nccnc3c2)n1	10.1021/jm9605142
		3191	102858	97	None	-8	25	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-8	25	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		122295	9868	7	None	-9	9	Rat	6.5	pKi	=	6.5	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		CHEMBL114166	9868	7	None	-9	9	Rat	6.5	pKi	=	6.5	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	10.1021/jm00018a001
		72947315	92489	0	None	-3	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	4	1.6	c1ccc(OC2CC2)c(OCC2=NCCN2)c1	10.1021/ml400232p
		CHEMBL2431280	92489	0	None	-3	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	4	1.6	c1ccc(OC2CC2)c(OCC2=NCCN2)c1	10.1021/ml400232p
		44456400	12834	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL1188501	12834	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL2436555	12834	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		CHEMBL536539	12834	0	None	-1	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysisDisplacement of [3H]Rauwolscine from human recombinant alpha2A-adrenoceptor expressed in MDCK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
		57400959	71188	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956200	71188	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	268	4	1	5	0.9	CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1	10.1016/j.bmc.2012.01.035
		10337773	101585	0	None	-79	10	Human	4.5	pKi	=	4.5	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL298612	101585	0	None	-79	10	Human	4.5	pKi	=	4.5	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		6424833	99172	101	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	178	1	1	3	1.2	O=[N+]([O-])c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		CHEMBL281289	99172	101	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	178	1	1	3	1.2	O=[N+]([O-])c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		10584556	207994	4	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	210	2	1	3	1.6	O=[N+]([O-])c1ccc2c(c1)CNC(CF)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL97282	207994	4	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	210	2	1	3	1.6	O=[N+]([O-])c1ccc2c(c1)CNC(CF)C2	10.1016/j.bmcl.2004.12.013
		3930	2151	43	None	-112	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	368	3	1	4	4.9	CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2	10.1021/jm060262x
		540335	2151	43	None	-112	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	368	3	1	4	4.9	CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2	10.1021/jm060262x
		CHEMBL106525	2151	43	None	-112	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	368	3	1	4	4.9	CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2	10.1021/jm060262x
		132075278	162644	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		CHEMBL4169752	162644	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
		44415689	139109	0	None	-363	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL378669	139109	0	None	-363	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11385652	78936	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	460	6	0	6	3.7	CCOC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112975	78936	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	460	6	0	6	3.7	CCOC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		118717248	115124	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
		CHEMBL3343699	115124	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1ccc2cnn(N=C3NCCN3)c2c1	10.1016/j.ejmech.2014.09.083
		4038180	204	14	None	-3	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1007/s00044-004-0020-z
		480	204	14	None	-3	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1007/s00044-004-0020-z
		CHEMBL109783	204	14	None	-3	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Homo sapiens (human) alpha2A receptorBinding affinity to Homo sapiens (human) alpha2A receptor	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1007/s00044-004-0020-z
		4038180	204	14	None	-3	7	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm030551a
		480	204	14	None	-3	7	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm030551a
		CHEMBL109783	204	14	None	-3	7	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm030551a
		11186227	84722	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL222798	84722	0	None	9	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	CC(Oc1ccccc1-c1ccc(O)cc1)C1=NCCN1	10.1021/jm0408215
		13141187	130716	0	None	-9	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	378	1	0	3	5.2	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368475	130716	0	None	-9	2	Bovine	6.5	pKi	=	6.5	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	378	1	0	3	5.2	CN1CCC(=C2c3cc(SC(F)(F)F)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		9809007	172564	8	None	-1905	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		CHEMBL448620	172564	8	None	-1905	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	608	10	2	7	5.6	COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		162658038	181146	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	530	10	5	13	0.4	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4760727	181146	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	530	10	5	13	0.4	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		70788951	27155	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		CHEMBL1366	27155	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL		None	None	None		None	nan
		90644726	112708	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	2	2	2	1.3	CC1CN/C(=N/c2ccc(N(C)C)cc2)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289542	112708	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	2	2	2	1.3	CC1CN/C(=N/c2ccc(N(C)C)cc2)N1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304469	112708	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	218	2	2	2	1.3	CC1CN/C(=N/c2ccc(N(C)C)cc2)N1	10.1016/j.ejmech.2014.05.057
		155539605	172845	0	None	-14	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assayDisplacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		CHEMBL4514672	172845	0	None	-14	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assayDisplacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
		8447	188949	84	None	-4	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	188949	84	None	-4	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		11199593	137199	0	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	1	3	3.8	CC(Sc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL374954	137199	0	None	2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	282	4	1	3	3.8	CC(Sc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		44288769	101148	0	None	-3090	7	Human	5.5	pKi	=	5.5	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	542	7	1	4	4.5	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL295395	101148	0	None	-3090	7	Human	5.5	pKi	=	5.5	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	542	7	1	4	4.5	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		10176433	20648	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	186	0	1	2	1.5	C1=NCC2(CCc3ccccc3C2)N1	10.1021/jm00020a021
		CHEMBL130853	20648	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	186	0	1	2	1.5	C1=NCC2(CCc3ccccc3C2)N1	10.1021/jm00020a021
		135398737	958	93	None	-26	89	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-26	89	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-26	89	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-26	89	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-26	89	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		44325027	207074	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cnc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL91824	207074	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	474	6	0	8	3.2	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cnc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		45487958	198391	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.5	Cc1ccccc1COC1=NCCN1	10.1021/jm901262f
		CHEMBL576819	198391	0	None	11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	190	2	1	3	1.5	Cc1ccccc1COC1=NCCN1	10.1021/jm901262f
		10376607	13360	0	None	1	2	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cnc(N2CCNCC2)c2ncc(C)n12	10.1021/jm00099a012
		CHEMBL1192423	13360	0	None	1	2	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cnc(N2CCNCC2)c2ncc(C)n12	10.1021/jm00099a012
		CHEMBL543653	13360	0	None	1	2	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cnc(N2CCNCC2)c2ncc(C)n12	10.1021/jm00099a012
		10332138	9559	3	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	246	1	1	3	2.2	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)(F)F)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL112351	9559	3	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	246	1	1	3	2.2	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)(F)F)C2	10.1016/j.bmcl.2004.12.013
		5226	97063	31	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	212	1	2	3	-0.0	NS(=O)(=O)c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		CHEMBL26717	97063	31	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	212	1	2	3	-0.0	NS(=O)(=O)c1ccc2c(c1)CNCC2	10.1016/j.bmcl.2004.12.013
		75201901	166425	19	None	-251	24	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-251	24	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		213	3853	55	None	-10	44	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		2717	3853	55	None	-10	44	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		5533	3853	55	None	-10	44	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		CHEMBL621	3853	55	None	-10	44	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		DB00656	3853	55	None	-10	44	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
		9798466	134278	1	None	-44	6	Rat	6.5	pKi	=	6.5	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		CHEMBL37170	134278	1	None	-44	6	Rat	6.5	pKi	=	6.5	Binding	In vivo binding affinity was evaluated against Alpha-1 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-1 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
		14004037	53771	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL160388	53771	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		36324	27123	76	None	-	1	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		CHEMBL1365675	27123	76	None	-	1	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	293	4	0	2	4.9	Cc1ccc(/N=C/N(C)/C=N/c2ccc(C)cc2C)c(C)c1	nan
		14004037	53771	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL160388	53771	2	None	8	2	Bovine	6.5	pKi	=	6.5	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	209	0	1	4	1.8	Nc1nc2c(s1)CCN1CCCCC21	10.1021/jm00398a025
		46869265	16257	0	None	-16	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		CHEMBL1224527	16257	0	None	-16	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		1548953	207679	27	None	-1	17	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	207679	27	None	-1	17	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		9895326	207027	0	None	-331	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	12	3	6	5.7	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1	10.1021/jm980077m
		CHEMBL91550	207027	0	None	-331	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	12	3	6	5.7	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1	10.1021/jm980077m
		57345628	71183	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1956195	71183	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		57345628	71183	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956195	71183	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		68712	100338	60	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL289480	100338	60	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		57345628	71183	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		CHEMBL1956195	71183	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	CC(Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		11608298	65076	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	228	2	1	3	1.9	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)F)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL182376	65076	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	228	2	1	3	1.9	O=[N+]([O-])c1ccc2c(c1)CNC(C(F)F)C2	10.1016/j.bmcl.2004.12.013
		16090634	82294	0	None	-4	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	296	3	1	4	3.2	Cc1cncc(C)c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		CHEMBL217180	82294	0	None	-4	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	296	3	1	4	3.2	Cc1cncc(C)c1Nc1ccc(N2CCN(C)CC2)cc1	10.1021/jm060262x
		3072540	82415	13	None	-97	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	382	4	1	4	5.3	CCN1CCN(c2ccc(Nc3c4ccccc4nc4ccccc34)cc2)CC1	10.1021/jm060262x
		CHEMBL217366	82415	13	None	-97	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	382	4	1	4	5.3	CCN1CCN(c2ccc(Nc3c4ccccc4nc4ccccc34)cc2)CC1	10.1021/jm060262x
		9817256	204238	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		CHEMBL71001	204238	0	None	-2	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		44390749	63910	0	None	-199	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	607	11	3	6	5.3	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL180561	63910	0	None	-199	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	607	11	3	6	5.3	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1016/s0960-894x(99)00484-9
		441383	20333	57	None	-2	16	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	20333	57	None	-2	16	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		94459	64274	127	None	64	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	163	1	1	3	0.5	c1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		CHEMBL18094	64274	127	None	64	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	163	1	1	3	0.5	c1ccc(N2CCNCC2)nc1	10.1021/jm00366a007
		3086326	204531	22	None	1	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL72753	204531	22	None	1	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	247	1	2	5	1.7	Clc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		11173568	84641	0	None	8	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL222371	84641	0	None	8	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	281	4	2	4	2.7	CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1	10.1021/jm0408215
		10083242	13834	1	None	5	3	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	2	1	5	1.3	CC(C)c1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1195814	13834	1	None	5	3	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	2	1	5	1.3	CC(C)c1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL555391	13834	1	None	5	3	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	2	1	5	1.3	CC(C)c1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		3584	3777	64	None	-251	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		5401	3777	64	None	-251	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		7302	3777	64	None	-251	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		CHEMBL611	3777	64	None	-251	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		DB01162	3777	64	None	-251	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00018a001
		9894818	98925	0	None	-83	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL279436	98925	0	None	-83	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	593	10	3	6	4.9	CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		155547141	173619	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	518	9	0	7	5.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(Oc4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4533687	173619	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	518	9	0	7	5.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(Oc4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		56964794	74064	0	None	-19	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	418	3	0	5	4.8	Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2	10.1021/jm2013419
		CHEMBL2022272	74064	0	None	-19	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	418	3	0	5	4.8	Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2	10.1021/jm2013419
		12774559	189609	0	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		CHEMBL51479	189609	0	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		44574080	188946	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	264	2	0	4	2.6	Cn1cc(-c2ccccc2[C@@H]2Cc3nccn3C2)cn1	10.1016/j.bmcl.2009.03.166
		CHEMBL508084	188946	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	264	2	0	4	2.6	Cn1cc(-c2ccccc2[C@@H]2Cc3nccn3C2)cn1	10.1016/j.bmcl.2009.03.166
		44312036	204565	1	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
		CHEMBL72995	204565	1	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.2	CC1CN=C(Nc2ccc3nccnc3c2Br)N1	10.1016/0960-894X(95)00391-6
		57401787	71253	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	308	3	1	4	2.3	c1ccc(C2(c3ccccc3)COCC(C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956906	71253	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	308	3	1	4	2.3	c1ccc(C2(c3ccccc3)COCC(C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL5094181	215480	22	None	-12	5	Human	5.4	pKi	=	5.4	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		CHEMBL5094181	215480	22	None	-12	5	Human	5.4	pKi	=	5.4	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
		90644724	112710	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	3	3	2	3.2	CN(C)c1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289522	112710	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	3	3	2	3.2	CN(C)c1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304483	112710	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	3	3	2	3.2	CN(C)c1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		10221005	204322	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	4	2	5	0.8	Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		CHEMBL71479	204322	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	267	4	2	5	0.8	Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
		10682720	205162	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	259	3	2	3	3.8	COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C	10.1021/jm9605142
		CHEMBL78190	205162	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	259	3	2	3	3.8	COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C	10.1021/jm9605142
		12981867	120357	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		CHEMBL353139	120357	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	230	2	1	2	2.5	Fc1cccc2c1C=C(CC1CN=CN1)CC2	10.1021/jm001040g
		49836308	18784	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1278084	18784	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		11651319	181628	27	None	17	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cnccc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL47740	181628	27	None	17	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cnccc1N1CCNCC1	10.1021/jm00366a007
		21584368	199852	3	None	4	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1016/j.bmcl.2004.12.013
		CHEMBL59441	199852	3	None	4	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	208	2	2	4	0.6	O=[N+]([O-])c1ccc2c(c1)CNC(CO)C2	10.1016/j.bmcl.2004.12.013
		164585473	184562	0	None	-7	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to alpha2a (unknown origin)Binding affinity to alpha2a (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4848380	184562	0	None	-7	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to alpha2a (unknown origin)Binding affinity to alpha2a (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		10841387	99618	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		CHEMBL284103	99618	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00019a001
		11079593	204115	0	None	1	4	Human	6.4	pKi	=	6.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70326	204115	0	None	1	4	Human	6.4	pKi	=	6.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		10841387	99618	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL284103	99618	0	None	-112	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	607	10	3	6	5.2	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		153287574	175247	0	None	-5	10	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4572167	175247	0	None	-5	10	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		24906203	187218	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		CHEMBL492445	187218	0	None	2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1	10.1021/jm800250z
		57384051	71249	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2CO[C@@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956902	71249	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2CO[C@@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		136274357	78944	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	412	4	1	5	3.8	c1ccc2c(c1)NC[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		CHEMBL2112984	78944	0	None	2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	412	4	1	5	3.8	c1ccc2c(c1)NC[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1	10.1021/jm049619s
		49864336	15617	0	None	11	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	453	9	1	5	3.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221545	15617	0	None	11	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	453	9	1	5	3.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		13507646	119614	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL346492	119614	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		13507646	119614	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL346492	119614	0	None	3	2	Bovine	8.4	pKi	=	8.4	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	243	0	0	2	4.0	c1ccc2c3c(sc2c1)C1CCCCN1CC3	10.1021/jm00398a025
		1593	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		30668	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		9868	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		CHEMBL17860	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		DB04948	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1016/j.bmc.2012.01.035
		102	4127	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		3659	4127	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		8969	4127	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		CHEMBL15245	4127	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		DB01392	4127	48	None	-15	49	Pig	8.4	pKi	=	8.4	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00018a001
		78114881	171781	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	288	5	0	6	0.9	CCOP(=O)(OCC)C1N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4467833	171781	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	288	5	0	6	0.9	CCOP(=O)(OCC)C1N=CC2C(=O)N(C)C(=O)C21	10.1021/acs.jmedchem.9b02080
		42273326	15616	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	403	7	1	4	3.8	COc1ccccc1N1CCN(CCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221544	15616	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	403	7	1	4	3.8	COc1ccccc1N1CCN(CCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		136	3292	32	None	-3	15	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		223	3292	32	None	-3	15	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		643606	3292	32	None	-3	15	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		CHEMBL10347	3292	32	None	-3	15	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		42388639	188054	0	None	-1	6	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL497749	188054	0	None	-1	6	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		11191321	62985	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	503	6	0	7	4.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C(C)(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		CHEMBL178588	62985	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	503	6	0	7	4.5	C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C(C)(C)C)cc4OC[C@H]32)CC1	10.1021/jm049619s
		2142	3096	58	None	-2	36	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		4920903	3096	58	None	-2	36	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		502	3096	58	None	-2	36	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		5775	3096	58	None	-2	36	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		CHEMBL597	3096	58	None	-2	36	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		DB00692	3096	58	None	-2	36	Rat	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1021/jm00018a001
		44404326	133524	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	283	3	2	5	2.7	Cc1ccc(N(NC2=NCCO2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		CHEMBL370818	133524	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	283	3	2	5	2.7	Cc1ccc(N(NC2=NCCO2)c2cccc(O)c2)cc1	10.1016/j.bmcl.2005.07.083
		135	2532	43	None	-4	58	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		1796	2532	43	None	-4	58	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		4184	2532	43	None	-4	58	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		CHEMBL6437	2532	43	None	-4	58	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		DB06148	2532	43	None	-4	58	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		9795515	204820	0	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	273	3	2	3	4.1	COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C	10.1021/jm9605142
		CHEMBL75257	204820	0	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	273	3	2	3	4.1	COc1c(C(C)(C)C)cc(C)c(Nc2ncc[nH]2)c1C	10.1021/jm9605142
		2585	803	103	None	-28	21	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	803	103	None	-28	21	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	803	103	None	-28	21	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	803	103	None	-28	21	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	803	103	None	-28	21	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		155515982	170010	0	None	-1584	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4442460	170010	0	None	-1584	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		44438147	93489	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL246228	93489	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	10.1016/j.bmcl.2006.12.094
		10032383	110110	0	None	-389	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	666	15	4	8	4.2	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1	10.1016/s0960-894x(99)00484-9
		136680387	110110	0	None	-389	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	666	15	4	8	4.2	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL323579	110110	0	None	-389	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	666	15	4	8	4.2	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1	10.1016/s0960-894x(99)00484-9
		73213196	104460	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adrenergic alpha 2A receptor (unknown origin)Binding affinity to adrenergic alpha 2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		CHEMBL3104093	104460	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adrenergic alpha 2A receptor (unknown origin)Binding affinity to adrenergic alpha 2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
		73213196	104460	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	104460	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		44401105	69576	0	None	-45	9	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193435	69576	0	None	-45	9	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		73213196	104460	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		CHEMBL3104093	104460	4	None	-3	13	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
		11109088	204180	0	None	-8	6	Human	7.4	pKi	=	7.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70751	204180	0	None	-8	6	Human	7.4	pKi	=	7.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
		70695474	77672	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL2089156	77672	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		11173544	166261	0	None	6	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1	10.1021/jm0408215
		CHEMBL426900	166261	0	None	6	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1	10.1021/jm0408215
		70695474	77672	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		CHEMBL2089156	77672	0	None	-7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		4209	3163	75	None	-1862	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		4893	3163	75	None	-1862	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		503	3163	75	None	-1862	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		5385	3163	75	None	-1862	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		CHEMBL2	3163	75	None	-1862	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		DB00457	3163	75	None	-1862	33	Pig	5.4	pKi	=	5.4	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm00018a001
		9885114	119604	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		CHEMBL346389	119604	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptorInhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/jm990277d
		9885114	119604	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/acs.jmedchem.7b00151
		CHEMBL346389	119604	5	None	-95	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of alpha2A adrenergic receptor (unknown origin)Inhibition of alpha2A adrenergic receptor (unknown origin)	ChEMBL	357	3	1	4	3.0	O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1	10.1021/acs.jmedchem.7b00151
		57326584	74065	0	None	-4	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	396	1	0	5	4.9	Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2	10.1021/jm2013419
		CHEMBL2022273	74065	0	None	-4	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	396	1	0	5	4.9	Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2	10.1021/jm2013419
		24906196	187246	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	261	6	1	5	1.8	CCO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		CHEMBL492639	187246	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	261	6	1	5	1.8	CCO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		11500225	101201	61	None	38	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	289	1	1	3	1.1	Ic1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL295764	101201	61	None	38	2	Bovine	7.4	pKi	=	7.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	289	1	1	3	1.1	Ic1cccnc1N1CCNCC1	10.1021/jm00366a007
		44438167	148970	0	None	-52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL394218	148970	0	None	-52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	10.1016/j.bmcl.2006.12.094
		1265	942	60	None	-75	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		6422124	942	60	None	-75	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		CHEMBL14638	942	60	None	-75	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	270	7	1	3	3.0	O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1	10.1021/jm8003625
		13123533	194909	1	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		CHEMBL541208	194909	1	None	-	1	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		62381256	112766	2	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	5	3	2	2.4	CCCNC(=N)Nc1ccc(OCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289535	112766	2	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	5	3	2	2.4	CCCNC(=N)Nc1ccc(OCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3305460	112766	2	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	221	5	3	2	2.4	CCCNC(=N)Nc1ccc(OCC)cc1	10.1016/j.ejmech.2014.05.057
		13869716	160280	8	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	199	1	1	3	1.5	Cn1c(C2=NCCN2)cc2ccccc21	10.1021/acs.jmedchem.9b02080
		CHEMBL41103	160280	8	None	-	1	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	199	1	1	3	1.5	Cn1c(C2=NCCN2)cc2ccccc21	10.1021/acs.jmedchem.9b02080
		71456239	78940	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	385	5	0	4	3.8	C1=C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL2112979	78940	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	385	5	0	4	3.8	C1=C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		13141185	60488	0	None	-9	2	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	356	0	0	2	4.3	CN1CCC(=C2c3cc(Br)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL175508	60488	0	None	-9	2	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	356	0	0	2	4.3	CN1CCC(=C2c3cc(Br)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		10401405	9677	16	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	279	0	1	1	3.0	FC(F)(F)C1Cc2ccc(Br)cc2CN1	10.1016/j.bmcl.2004.12.013
		CHEMBL112964	9677	16	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	279	0	1	1	3.0	FC(F)(F)C1Cc2ccc(Br)cc2CN1	10.1016/j.bmcl.2004.12.013
		2719	917	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		5535	917	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		607	917	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		CHEMBL76	917	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		DB00608	917	74	None	-4	11	Human	5.4	pKi	=	5.4	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		45588795	112757	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	2	3	3	2.9	N=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289534	112757	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	2	3	3	2.9	N=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305316	112757	4	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	255	2	3	3	2.9	N=C(Nc1ccccc1)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2014.05.057
		4098	32505	30	None	-13	11	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	-13	11	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	-13	11	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		49836304	18571	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276219	18571	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/ml400232p
		70693375	77671	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL2089155	77671	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml400232p
		49836304	18571	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276219	18571	1	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	4	1	3	2.3	C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1	10.1021/jm100977d
		49836305	18576	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276248	18576	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		70693375	77671	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		CHEMBL2089155	77671	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	244	5	1	3	2.4	C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1	10.1021/ml300064v
		9944409	7613	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	307	3	3	4	2.0	CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL108804	7613	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	307	3	3	4	2.0	CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		44579272	187095	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
		CHEMBL491420	187095	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	499	7	0	9	4.3	c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1	10.1016/j.bmcl.2008.08.055
		10397358	174987	44	None	70	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	178	1	2	4	0.1	Nc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL45665	174987	44	None	70	2	Bovine	6.4	pKi	=	6.4	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	178	1	2	4	0.1	Nc1cccnc1N1CCNCC1	10.1021/jm00366a007
		44579231	181567	0	None	-28	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	396	6	1	6	1.7	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1	10.1016/j.bmcl.2008.08.055
		CHEMBL476774	181567	0	None	-28	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	396	6	1	6	1.7	O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1	10.1016/j.bmcl.2008.08.055
		135418497	63039	0	None	-1949	4	Human	6.4	pKi	=	6.4	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4NC(=O)N32)CC1	10.1021/jm970159v
		CHEMBL1788222	63039	0	None	-1949	4	Human	6.4	pKi	=	6.4	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4NC(=O)N32)CC1	10.1021/jm970159v
		2812	4779	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		10531532	207094	0	None	-51	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	594	9	2	7	6.0	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL91956	207094	0	None	-51	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	594	9	2	7	6.0	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		10199335	204747	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL74467	204747	0	None	-5	4	Human	5.4	pKi	=	5.4	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
		49781008	17250	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	3	1	2	3.3	CC(C)O[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256608	17250	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	254	3	1	2	3.3	CC(C)O[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		11371902	141638	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL385310	141638	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm0408215
		11371902	141638	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL385310	141638	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	272	4	1	4	3.2	CC(Oc1ccccc1-c1ccsc1)C1=NCCN1	10.1021/jm100977d
		121938	141895	20	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	215	0	1	1	3.0	Clc1ccc2c(c1Cl)CNCCC2	10.1021/jm0205752
		CHEMBL38681	141895	20	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibitory potency against alpha-2-adrenoceptorInhibitory potency against alpha-2-adrenoceptor	ChEMBL	215	0	1	1	3.0	Clc1ccc2c(c1Cl)CNCCC2	10.1021/jm0205752
		10436842	100256	0	None	-5754	7	Human	5.3	pKi	=	5.3	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.6	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		CHEMBL288772	100256	0	None	-5754	7	Human	5.3	pKi	=	5.3	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	524	7	1	4	4.6	CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C	10.1016/s0960-894x(99)00696-4
		57326586	74066	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	402	5	1	7	2.5	OCCOCCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		CHEMBL2022275	74066	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	402	5	1	7	2.5	OCCOCCN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm2013419
		44438165	166784	0	None	-48	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL428407	166784	0	None	-48	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	10.1016/j.bmcl.2006.12.094
		16007117	80036	0	None	-457	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212912	80036	0	None	-457	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415704	80159	0	None	-158	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213424	80159	0	None	-158	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		155538007	172355	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4475933	172355	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	444	7	0	6	4.1	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		3561	19077	39	None	-1	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	19077	39	None	-1	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		499	4077	18	None	-346	14	Rat	7.3	pKi	=	7.3	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		5685	4077	18	None	-346	14	Rat	7.3	pKi	=	7.3	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		CHEMBL25554	4077	18	None	-346	14	Rat	7.3	pKi	=	7.3	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm00018a001
		11300487	85002	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1	10.1021/jm0408215
		CHEMBL223830	85002	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1	10.1021/jm0408215
		10467319	203842	14	None	-9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity at alpha-2 adrenergic receptor of rat.Binding affinity at alpha-2 adrenergic receptor of rat.	ChEMBL	250	0	2	1	2.6	Brc1cccc2c3c([nH]c12)CNCC3	10.1016/j.bmcl.2003.11.078
		CHEMBL6857	203842	14	None	-9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity at alpha-2 adrenergic receptor of rat.Binding affinity at alpha-2 adrenergic receptor of rat.	ChEMBL	250	0	2	1	2.6	Brc1cccc2c3c([nH]c12)CNCC3	10.1016/j.bmcl.2003.11.078
		6455104	98486	6	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	172	2	1	2	1.7	C(=C/c1ccccc1)\C1=NCCN1	10.1021/acs.jmedchem.9b02080
		CHEMBL275970	98486	6	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	172	2	1	2	1.7	C(=C/c1ccccc1)\C1=NCCN1	10.1021/acs.jmedchem.9b02080
		15853467	208134	0	None	-141	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Alpha-2A adrenergic receptorBinding affinity against human Alpha-2A adrenergic receptor	ChEMBL	692	16	3	8	5.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1	10.1016/s0960-894x(99)00484-9
		CHEMBL98063	208134	0	None	-141	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Alpha-2A adrenergic receptorBinding affinity against human Alpha-2A adrenergic receptor	ChEMBL	692	16	3	8	5.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1	10.1016/s0960-894x(99)00484-9
		44574134	178504	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	269	2	0	4	3.0	Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL466634	178504	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	269	2	0	4	3.0	Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		44387798	166273	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	458	7	0	5	3.9	CC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(CCC/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		CHEMBL426959	166273	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	458	7	0	5	3.9	CC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(CCC/C=C/c3ccccc3)CC2)c2ccccc21	10.1021/jm049619s
		11108001	10872	2	None	-4	6	Human	7.3	pKi	=	7.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL117248	10872	2	None	-4	6	Human	7.3	pKi	=	7.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL540542	10872	2	None	-4	6	Human	7.3	pKi	=	7.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		44352207	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
		CHEMBL128168	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm800250z
		44352207	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL128168	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		44352207	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL128168	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		44352207	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL128168	18856	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	CC(Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		162674829	183274	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	513	11	5	11	1.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4796664	183274	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	513	11	5	11	1.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		164614469	184781	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	341	1	0	3	3.9	C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4851349	184781	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	341	1	0	3	3.9	C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		13149	2545	36	None	-77	17	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.9b01465
		3034396	2545	36	None	-77	17	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.9b01465
		CHEMBL299031	2545	36	None	-77	17	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.9b01465
		44269013	30342	1	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	218	5	1	3	2.0	CCCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		CHEMBL13917	30342	1	None	1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	218	5	1	3	2.0	CCCc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		45487962	197485	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	218	4	1	3	2.1	CCCc1ccccc1COC1=NCCN1	10.1021/jm901262f
		CHEMBL569933	197485	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	218	4	1	3	2.1	CCCc1ccccc1COC1=NCCN1	10.1021/jm901262f
		11776640	13546	0	None	2	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	3	1	5	1.1	CCCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1193824	13546	0	None	2	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	3	1	5	1.1	CCCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL545293	13546	0	None	2	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	245	3	1	5	1.1	CCCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		163198500	186398	3	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	371	1	0	3	3.2	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	10.1016/j.bmcl.2021.128008
		CHEMBL4875858	186398	3	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	371	1	0	3	3.2	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	10.1016/j.bmcl.2021.128008
		15407445	200278	2	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	192	1	1	3	1.6	CC1Cc2ccc([N+](=O)[O-])cc2CN1	10.1016/j.bmcl.2004.12.013
		CHEMBL59719	200278	2	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	192	1	1	3	1.6	CC1Cc2ccc([N+](=O)[O-])cc2CN1	10.1016/j.bmcl.2004.12.013
		132060743	162236	0	None	-1	13	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4163428	162236	0	None	-1	13	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		57395732	71191	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	342	5	1	3	4.8	CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956203	71191	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	342	5	1	3	4.8	CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		70696790	76299	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	3	1	3	1.5	CC1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		CHEMBL2058632	76299	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	194	3	1	3	1.5	CC1COC(NC(C2CC2)C2CC2)=N1	10.1016/j.bmc.2012.06.008
		90644748	112735	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	4	4	2	3.6	CCNc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289520	112735	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	4	4	2	3.6	CCNc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304855	112735	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	254	4	4	2	3.6	CCNc1ccc(NC(=N)Nc2ccccc2)cc1	10.1016/j.ejmech.2014.05.057
		155517797	170213	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	498	8	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC34CC5CC(CC(C5)C3)C4)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4445396	170213	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	498	8	0	6	5.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(CC34CC5CC(CC(C5)C3)C4)C(=O)C21	10.1021/acs.jmedchem.9b02080
		102	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		3659	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		8969	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		CHEMBL15245	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		DB01392	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00366a007
		102	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		3659	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		8969	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		CHEMBL15245	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		DB01392	4127	48	None	-47	49	Bovine	7.3	pKi	=	7.3	Binding	Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortexEvaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00150a002
		191	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-41	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		13298530	99072	20	None	97	2	Bovine	8.3	pKi	=	8.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	195	1	0	3	1.0	CN1CCN(c2ncccc2F)CC1	10.1021/jm00366a007
		CHEMBL280514	99072	20	None	97	2	Bovine	8.3	pKi	=	8.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	195	1	0	3	1.0	CN1CCN(c2ncccc2F)CC1	10.1021/jm00366a007
		44215744	207442	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL94129	207442	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		521	1404	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		5311068	1404	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		835	1404	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		CHEMBL778	1404	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		DB00633	1404	69	None	-2	7	Rat	8.3	pKi	=	8.3	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	10.1021/jm000128r
		42267840	15604	2	None	4	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	425	7	1	5	2.9	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221499	15604	2	None	4	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	425	7	1	5	2.9	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		44330857	4394	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4OC)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL101361	4394	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	493	8	0	8	3.5	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4OC)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		294234	102893	3	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
		CHEMBL305928	102893	3	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	182	1	1	3	1.7	C1CCCC(NC2=NCCO2)CC1	10.1016/0960-894X(94)85032-1
		31101	729	40	None	-10	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	729	40	None	-10	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	729	40	None	-10	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	729	40	None	-10	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	729	40	None	-10	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		13123525	189198	0	None	-	1	Bovine	8.3	pKi	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		CHEMBL51131	189198	0	None	-	1	Bovine	8.3	pKi	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	265	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)c2ccccc2)cc1	10.1021/jm00366a022
		44330598	207638	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL95218	207638	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4cccc(F)c4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		10220053	206920	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1016/s0960-894x(03)00525-0
		CHEMBL90997	206920	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1016/s0960-894x(03)00525-0
		10220053	206920	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1021/jm049619s
		CHEMBL90997	206920	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorInhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptor	ChEMBL	218	2	1	2	1.9	Fc1ccc2c(c1)CC(CC1CN=CN1)C2	10.1021/jm049619s
		1343	1889	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		3519	1889	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		522	1889	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		CHEMBL862	1889	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		DB01018	1889	62	None	-11	9	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
		100	3805	58	None	-33	55	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-33	55	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-33	55	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-33	55	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-33	55	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		73291731	92491	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	3	2.4	CCCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		CHEMBL2431282	92491	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	232	5	1	3	2.4	CCCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		117590588	96524	35	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	10.1021/jm001040g
		14969	96524	35	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	10.1021/jm001040g
		CHEMBL262777	96524	35	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	10.1021/jm001040g
		24906199	187665	15	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
		CHEMBL495096	187665	15	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	258	4	1	3	3.1	CC(Oc1ccccc1C1CCCC1)C1=NCCN1	10.1021/jm800250z
		45487955	198310	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	232	4	1	3	2.7	CCCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		CHEMBL576078	198310	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	232	4	1	3	2.7	CCCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		2771431	188282	52	None	1	2	Bovine	6.3	pKi	=	6.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.8	Clc1cnc(N2CCNCC2)c(Cl)c1	10.1021/jm00366a007
		CHEMBL50016	188282	52	None	1	2	Bovine	6.3	pKi	=	6.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.8	Clc1cnc(N2CCNCC2)c(Cl)c1	10.1021/jm00366a007
		9923679	81762	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	332	3	1	4	4.0	Cc1cc(Nc2ccc(N3CCN(C)CC3)cc2)c2ccccc2n1	10.1021/jm060262x
		CHEMBL216399	81762	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	332	3	1	4	4.0	Cc1cc(Nc2ccc(N3CCN(C)CC3)cc2)c2ccccc2n1	10.1021/jm060262x
		162651072	180180	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	527	12	5	11	1.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4749263	180180	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	527	12	5	11	1.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		137641762	158099	0	None	-15	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	476	5	4	10	1.1	CCCNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.7b00141
		CHEMBL4086593	158099	0	None	-15	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	476	5	4	10	1.1	CCCNc1nc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.7b00141
		137643541	158431	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	448	3	4	10	0.3	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(C#Cc4ccc(Cl)s4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00141
		CHEMBL4090355	158431	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor	ChEMBL	448	3	4	10	0.3	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(C#Cc4ccc(Cl)s4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00141
		3158	56267	27	None	-3467	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-3467	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		10651080	105942	0	None	-57	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	9	3	6	4.7	CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL312871	105942	0	None	-57	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	9	3	6	4.7	CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		57398332	71247	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc(C2COC(C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956900	71247	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc(C2COC(C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		10916464	204153	0	None	-10	5	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL70563	204153	0	None	-10	5	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1	10.1021/jm000542r
		44579184	190953	4	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		CHEMBL518592	190953	4	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	340	4	0	5	2.7	COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		132060776	162402	0	None	-1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		CHEMBL4165863	162402	0	None	-1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
		11820657	13444	1	None	6	2	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc(N3CCNCC3)c2n1	10.1021/jm00099a012
		CHEMBL1193017	13444	1	None	6	2	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc(N3CCNCC3)c2n1	10.1021/jm00099a012
		CHEMBL544354	13444	1	None	6	2	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	217	1	1	5	0.4	Cc1cn2ccnc(N3CCNCC3)c2n1	10.1021/jm00099a012
		10036255	21359	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL131417	21359	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1cccc2c1CC1(CC2)CN=CN1	10.1021/jm00020a021
		10036256	23781	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL133579	23781	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		11277479	84750	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1	10.1021/jm0408215
		CHEMBL222973	84750	0	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	4	1	3	3.4	Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1	10.1021/jm0408215
		10214826	4479	20	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	289	2	2	4	2.9	Brc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		CHEMBL1019	4479	20	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	289	2	2	4	2.9	Brc1c(Nc2ncc[nH]2)ccc2nccnc12	10.1021/jm9605142
		130442572	171908	0	None	-109	24	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-109	24	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		90644706	112743	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	269	3	3	2	3.3	N=C(NCc1ccco1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289531	112743	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	269	3	3	2	3.3	N=C(NCc1ccco1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3304994	112743	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	269	3	3	2	3.3	N=C(NCc1ccco1)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		4735	195115	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	195115	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	195115	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		3584	3777	64	None	-251	13	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		5401	3777	64	None	-251	13	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		7302	3777	64	None	-251	13	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		CHEMBL611	3777	64	None	-251	13	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		DB01162	3777	64	None	-251	13	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	nan
		10101373	13093	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	718	6	6	6	4.6	O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL1190317	13093	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	718	6	6	6	4.6	O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		CHEMBL540594	13093	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	ChEMBL	718	6	6	6	4.6	O=C(NCCCNC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21	10.1016/s0960-894x(00)00068-8
		24882007	12473	1	None	1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
		CHEMBL1186220	12473	1	None	1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	201	1	2	3	0.3	c1ccc2c(c1)cnn2N=C1NCCN1	10.1016/j.ejmech.2014.09.083
		49836301	18567	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml400232p
		CHEMBL1276140	18567	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml400232p
		49836301	18567	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/jm100977d
		CHEMBL1276140	18567	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/jm100977d
		49836301	18567	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml300064v
		CHEMBL1276140	18567	1	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1O[C@@H](C)C1=NCCN1	10.1021/ml300064v
		16785637	181577	80	None	11	2	Bovine	5.3	pKi	=	5.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	206	2	2	4	-0.4	NC(=O)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL47688	181577	80	None	11	2	Bovine	5.3	pKi	=	5.3	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	206	2	2	4	-0.4	NC(=O)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		162664704	182211	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4783068	182211	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	471	8	5	11	0.2	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2CNCc3ccccc32)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		73347825	92540	0	None	-3	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	311	5	1	3	2.9	COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2432046	92540	0	None	-3	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	311	5	1	3	2.9	COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC	10.1016/j.bmc.2013.07.045
		145973771	164719	0	None	-6	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4217398	164719	0	None	-6	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]Rauwolscine from human adrenergic alpha2A receptor expressed in MDCK cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		448537	160250	89	None	-33	25	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	160250	89	None	-33	25	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		155521287	170578	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4450506	170578	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		487	3634	21	None	-1513	11	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		60602	3634	21	None	-1513	11	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		CHEMBL405355	3634	21	None	-1513	11	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		DB09239	3634	21	None	-1513	11	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		10059780	12959	0	None	6	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	2	1	5	0.7	CCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL1189347	12959	0	None	6	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	2	1	5	0.7	CCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		CHEMBL538537	12959	0	None	6	3	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	2	1	5	0.7	CCc1cnc2c(N3CCNCC3)nccn12	10.1021/jm00099a012
		289	242	12	None	-47	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		9948320	242	12	None	-47	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		CHEMBL1242950	242	12	None	-47	14	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assayBinding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		2398	954	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-14	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		162643475	181743	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to alpha 2A adrenoceptor (unknown origin)Binding affinity to alpha 2A adrenoceptor (unknown origin)	ChEMBL	283	1	0	2	4.3	C=C1CCN2Cc3ccc(OC)cc3[C@H]3CCCC[C@]32C1	10.1021/acs.jmedchem.0c01192
		CHEMBL4777306	181743	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to alpha 2A adrenoceptor (unknown origin)Binding affinity to alpha 2A adrenoceptor (unknown origin)	ChEMBL	283	1	0	2	4.3	C=C1CCN2Cc3ccc(OC)cc3[C@H]3CCCC[C@]32C1	10.1021/acs.jmedchem.0c01192
		15730	71118	80	None	-2	10	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	71118	80	None	-2	10	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		155521287	170578	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4450506	170578	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	478	7	0	6	4.8	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(F)c(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		57394788	71250	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956903	71250	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		10092819	16773	0	None	-51	12	Rat	7.3	pKi	=	7.3	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		CHEMBL124444	16773	0	None	-51	12	Rat	7.3	pKi	=	7.3	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		44424855	85454	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL226636	85454	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		518	3612	1	None	-3	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	299	0	0	2	3.8	CN1CCc2c3c(C1)c(Br)oc3ccc2Cl	10.1021/jm00019a001
		9839317	3612	1	None	-3	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	299	0	0	2	3.8	CN1CCc2c3c(C1)c(Br)oc3ccc2Cl	10.1021/jm00019a001
		CHEMBL123138	3612	1	None	-3	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	299	0	0	2	3.8	CN1CCc2c3c(C1)c(Br)oc3ccc2Cl	10.1021/jm00019a001
		49781005	17214	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		CHEMBL1256503	17214	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	226	2	1	2	2.5	CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1	10.1021/jm1006269
		6075	150108	42	None	-11	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	-11	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		155548049	173697	0	None	-3	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2cccc(O)c2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		CHEMBL4535634	173697	0	None	-3	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2cccc(O)c2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		135559170	102060	0	None	-851	7	Human	6.3	pKi	=	6.3	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1	10.1021/jm970159v
		CHEMBL302021	102060	0	None	-851	7	Human	6.3	pKi	=	6.3	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	391	4	1	5	2.5	COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1	10.1021/jm970159v
		3584	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		5401	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		7302	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		CHEMBL611	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		DB01162	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm980077m
		9813756	9016	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	255	2	2	2	2.8	CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL109848	9016	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	255	2	2	2	2.8	CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		13123534	189453	1	None	-	1	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		CHEMBL51358	189453	1	None	-	1	Bovine	7.3	pKi	=	7.3	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand	ChEMBL	209	3	2	3	1.8	Clc1ccccc1NCC1=NCCN1	10.1021/jm00366a022
		2142	3096	58	None	-2	36	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		4920903	3096	58	None	-2	36	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		502	3096	58	None	-2	36	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		5775	3096	58	None	-2	36	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		CHEMBL597	3096	58	None	-2	36	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		DB00692	3096	58	None	-2	36	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1016/j.bmcl.2005.07.083
		3584	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		5401	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		7302	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		CHEMBL611	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		DB01162	3777	64	None	-251	13	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1021/jm00010a001
		12613159	187326	11	None	-16	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL493054	187326	11	None	-16	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		11465618	102398	23	None	-2089	19	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	102398	23	None	-2089	19	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	102398	23	None	-2089	19	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		9816461	10719	7	None	-9	4	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL117094	10719	7	None	-9	4	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL544290	10719	7	None	-9	4	Human	5.3	pKi	=	5.3	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		24906198	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		CHEMBL495095	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml400232p
		57402717	71187	2	None	14	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	220	4	1	4	1.5	COc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956199	71187	2	None	14	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	220	4	1	4	1.5	COc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		24906198	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		CHEMBL495095	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		45487145	197659	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	4	1	3	2.5	C=CCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		CHEMBL570973	197659	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	230	4	1	3	2.5	C=CCc1ccccc1C(C)OC1=NCCN1	10.1021/jm901262f
		24906198	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm100977d
		CHEMBL495095	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/jm100977d
		24906198	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml300064v
		CHEMBL495095	187664	3	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	230	5	1	3	2.2	C=CCc1ccccc1OC(C)C1=NCCN1	10.1021/ml300064v
		44329027	4168	0	None	-29	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	637	13	3	7	4.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL100045	4168	0	None	-29	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	637	13	3	7	4.9	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1	10.1016/s0960-894x(99)00484-9
		11097789	102998	1	None	-11	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL306792	102998	1	None	-11	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
		2765	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		515	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		CHEMBL13852	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		DB09202	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/ml400232p
		2765	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		515	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		CHEMBL13852	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		DB09202	943	19	None	-1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1021/jm901262f
		16090621	141575	0	None	-16	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	5	1	4	5.6	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1Cc1ccccc1	10.1021/jm060262x
		CHEMBL384925	141575	0	None	-16	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	422	5	1	4	5.6	Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)CC3)cc2)c1Cc1ccccc1	10.1021/jm060262x
		1960	2857	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		439260	2857	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		505	2857	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		CHEMBL1437	2857	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		DB00368	2857	67	None	-35	26	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	nan
		9906978	42711	2	None	-165	12	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		CHEMBL150161	42711	2	None	-165	12	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assay	ChEMBL	361	6	1	3	4.0	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1	10.1016/j.bmcl.2006.03.057
		6726	1280	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	-10	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		150	2509	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	2509	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	2509	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	2509	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	2509	21	None	-45	16	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		9859437	168022	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
		CHEMBL432155	168022	0	None	38	3	Human	8.2	pKi	=	8.2	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	230	2	3	4	2.3	Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2	10.1021/jm9605142
		49864360	15627	0	None	15	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	445	10	1	4	5.0	COc1ccccc1N1CCN(CCCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221593	15627	0	None	15	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	445	10	1	4	5.0	COc1ccccc1N1CCN(CCCCCCNC(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		11653915	124012	0	None	-1	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	296	4	2	5	2.6	COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
		CHEMBL362954	124012	0	None	-1	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells	ChEMBL	296	4	2	5	2.6	COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1	10.1016/j.bmcl.2005.07.083
		1209	1658	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		203	1658	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		3386	1658	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		CHEMBL41	1658	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		DB00472	1658	75	None	-1	32	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1021/jm001040g
		131829	204727	15	None	7	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
		CHEMBL74283	204727	15	None	7	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	295	1	4	5	1.7	Brc1c(NC2=NCCN2)ccc2c1NCCN2	10.1016/0960-894X(95)00391-6
		135477797	78932	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112971	78932	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		2435	722	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		395	722	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		520	722	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		5386	722	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		CHEMBL844	722	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		DB00484	722	100	None	-2	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1016/0960-894X(95)00391-6
		10382537	204166	12	None	6	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL70676	204166	12	None	6	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	339	1	2	5	1.6	Ic1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		98358	119486	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL345349	119486	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		98358	119486	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		CHEMBL345349	119486	8	None	-1	2	Bovine	7.2	pKi	=	7.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	226	0	1	1	3.3	c1ccc2c3c([nH]c2c1)C1CCCCN1CC3	10.1021/jm00398a025
		11361608	84745	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL222928	84745	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		11361608	84745	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm0408215
		CHEMBL222928	84745	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm0408215
		11361608	84745	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL222928	84745	1	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		13141186	130691	0	None	-7	2	Bovine	6.2	pKi	=	6.2	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	312	0	0	2	4.2	CN1CCC(=C2c3cc(Cl)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368357	130691	0	None	-7	2	Bovine	6.2	pKi	=	6.2	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	312	0	0	2	4.2	CN1CCC(=C2c3cc(Cl)ccc3CCn3cccc32)CC1	10.1021/jm00361a008
		9851486	206699	0	None	-512	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	10	2	6	6.0	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL89685	206699	0	None	-512	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	592	10	2	6	6.0	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		155525779	171042	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.3	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4456882	171042	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	494	7	0	6	5.3	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		11771731	108246	2	None	-16	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		CHEMBL319706	108246	2	None	-16	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
		134	2514	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	2514	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	2514	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	2514	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	2514	24	None	-74	67	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		489	145	28	None	-1778	12	Human	6.2	pKi	=	6.2	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	401	7	1	8	1.0	COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C	10.1021/jm00018a001
		5640	145	28	None	-1778	12	Human	6.2	pKi	=	6.2	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	401	7	1	8	1.0	COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C	10.1021/jm00018a001
		CHEMBL420060	145	28	None	-1778	12	Human	6.2	pKi	=	6.2	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	ChEMBL	401	7	1	8	1.0	COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C	10.1021/jm00018a001
		10082625	13793	0	None	-4	3	Bovine	6.2	pKi	=	6.2	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cn2c(C)cnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL1195526	13793	0	None	-4	3	Bovine	6.2	pKi	=	6.2	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cn2c(C)cnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL554785	13793	0	None	-4	3	Bovine	6.2	pKi	=	6.2	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	1	5	0.8	Cc1cn2c(C)cnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		2750	204061	76	None	-3	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	204061	76	None	-3	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		2351	3286	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	3286	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	3286	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	3286	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	3286	64	None	-9	21	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		129211	3749	78	None	-120	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		2562	3749	78	None	-120	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		488	3749	78	None	-120	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		CHEMBL836	3749	78	None	-120	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		DB00706	3749	78	None	-120	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligandBinding affinity towards recombinant human alpha-2A adrenergic receptor was determined using [3H]MK-912 as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
		2274	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-10	31	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		10934575	204486	0	None	-3	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL72441	204486	0	None	-3	6	Human	7.2	pKi	=	7.2	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
		10823140	120366	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	2	1	2	2.5	C1=NC[C@H](C[C@]23CCc4ccccc4C2C3)N1	10.1021/jm001040g
		136078488	120366	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	2	1	2	2.5	C1=NC[C@H](C[C@]23CCc4ccccc4C2C3)N1	10.1021/jm001040g
		CHEMBL353212	120366	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellBinding affinity for human alpha-2 adrenergic receptor expressed in CHO cell	ChEMBL	226	2	1	2	2.5	C1=NC[C@H](C[C@]23CCc4ccccc4C2C3)N1	10.1021/jm001040g
		75306277	109254	0	None	-31	23	Human	7.2	pKi	=	7.2	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	109254	0	None	-31	23	Human	7.2	pKi	=	7.2	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		155550341	175103	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	458	8	0	6	4.2	CCOP(=O)(OCC)C1(Cc2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4568994	175103	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	458	8	0	6	4.2	CCOP(=O)(OCC)C1(Cc2ccc(F)cc2)N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		1042	1581	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	1581	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	1581	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	1581	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	1581	23	None	-97	17	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		16090635	82515	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	4	1	4	4.7	CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2	10.1021/jm060262x
		CHEMBL217768	82515	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	378	4	1	4	4.7	CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2	10.1021/jm060262x
		10508332	105991	0	None	-426	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	638	11	2	8	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1	10.1021/jm980077m
		CHEMBL313160	105991	0	None	-426	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	638	11	2	8	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1	10.1021/jm980077m
		10626982	111495	0	None	-11	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	575	9	2	6	5.9	CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		CHEMBL327775	111495	0	None	-11	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	575	9	2	6	5.9	CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1	10.1021/jm980077m
		1534	103040	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	103040	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	103040	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		155536080	172114	0	None	-43	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		CHEMBL4472703	172114	0	None	-43	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
		57394789	71251	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956904	71251	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@@H]2COC[C@@H](C3=NCCN3)O2)cc1	10.1016/j.bmc.2012.02.016
		1534	103040	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		9287	103040	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		CHEMBL30713	103040	53	None	-6	12	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]Clonidine from human recombinant adrenergic alpha2A receptor expressed in MDCK cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
		162677211	183560	0	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	516	9	5	13	-0.0	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4800292	183560	0	None	-	1	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	516	9	5	13	-0.0	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCC2Cc3ccc([N+](=O)[O-])cc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		487	3634	21	None	-1513	11	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		60602	3634	21	None	-1513	11	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		CHEMBL405355	3634	21	None	-1513	11	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		DB09239	3634	21	None	-1513	11	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00019a001
		10793963	99672	0	None	-69	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	11	2	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL284470	99672	0	None	-69	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	11	2	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		71652196	87454	0	None	-190	6	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	368	4	1	5	3.6	Oc1ccc(N2CCN(Cc3cnn(-c4ccc(Cl)cc4)c3)CC2)cc1	10.1016/j.ejmech.2012.08.011
		CHEMBL2333732	87454	0	None	-190	6	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting	ChEMBL	368	4	1	5	3.6	Oc1ccc(N2CCN(Cc3cnn(-c4ccc(Cl)cc4)c3)CC2)cc1	10.1016/j.ejmech.2012.08.011
		3652	46244	70	None	-1	9	Human	5.2	pKi	=	5.2	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		CHEMBL1535	46244	70	None	-1	9	Human	5.2	pKi	=	5.2	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		118717249	115125	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
		CHEMBL3343700	115125	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting	ChEMBL	219	1	2	3	0.5	Fc1cccc2cnn(N=C3NCCN3)c12	10.1016/j.ejmech.2014.09.083
		11741010	83251	0	None	-4	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL218730	83251	0	None	-4	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		164609539	184399	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	428	2	0	5	3.3	O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4845850	184399	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	428	2	0	5	3.3	O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		123920	100154	41	None	-309	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1016/j.bmcl.2004.12.013
		CHEMBL287837	100154	41	None	-309	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligandBinding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand	ChEMBL	201	0	1	1	2.6	Clc1ccc2c(c1Cl)CNCC2	10.1016/j.bmcl.2004.12.013
		71459553	83696	10	None	-3	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
		CHEMBL2205360	83696	10	None	-3	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
		1960	2857	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		439260	2857	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		505	2857	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		CHEMBL1437	2857	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		DB00368	2857	67	None	-23	26	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960012o
		44325044	207383	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL93801	207383	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		44401164	69816	0	None	-346	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-346	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		44579271	187094	0	None	-32	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		CHEMBL491419	187094	0	None	-32	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	475	9	0	7	4.2	c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1	10.1016/j.bmcl.2008.08.055
		14004035	119519	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		CHEMBL345621	119519	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		14004035	119519	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		CHEMBL345621	119519	0	None	-1	2	Bovine	6.2	pKi	=	6.2	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	227	0	1	2	2.6	c1cnc2[nH]c3c(c2c1)CCN1CCCCC31	10.1021/jm00398a025
		24906160	169456	0	None	1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	247	5	1	5	1.4	CO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		CHEMBL442815	169456	0	None	1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	247	5	1	5	1.4	CO/N=C/c1ccccc1OC(C)C1=NCCN1	10.1021/jm800250z
		441082	1163	48	None	-141	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	10.1021/jm8003625
		8981	1163	48	None	-141	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	10.1021/jm8003625
		CHEMBL191703	1163	48	None	-141	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells	ChEMBL	356	1	0	2	4.8	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C	10.1021/jm8003625
		122442272	138348	0	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3769968	138348	0	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		CHEMBL3771384	138348	0	None	-11	15	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human alpha-2A adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2A adrenergic receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
		240	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		2769	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		44279790	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		660	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL1729	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		CHEMBL560739	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		DB00604	944	43	None	-12	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
		196129	67798	17	None	-85	15	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	67798	17	None	-85	15	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		26757	207978	31	None	-1	2	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		CHEMBL972	207978	31	None	-1	2	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	nan
		10818003	106421	0	None	-12	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	649	12	3	6	6.2	CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1	10.1021/jm980077m
		CHEMBL313953	106421	0	None	-12	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	649	12	3	6	6.2	CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1	10.1021/jm980077m
		10603951	206516	0	None	-33	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	10	1	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		CHEMBL88448	206516	0	None	-33	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	622	10	1	7	6.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980077m
		90644753	112768	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	231	3	3	1	2.9	CCCNC(=N)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3289537	112768	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	231	3	3	1	2.9	CCCNC(=N)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		CHEMBL3305462	112768	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	231	3	3	1	2.9	CCCNC(=N)Nc1ccc2c(c1)CCCC2	10.1016/j.ejmech.2014.05.057
		3073596	44247	28	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	184	1	1	2	2.8	c1ccc2oc(-c3ncc[nH]3)cc2c1	10.1021/acs.jmedchem.9b02080
		CHEMBL151697	44247	28	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	184	1	1	2	2.8	c1ccc2oc(-c3ncc[nH]3)cc2c1	10.1021/acs.jmedchem.9b02080
		9816063	103074	0	None	-4	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		CHEMBL30739	103074	0	None	-4	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm990569e
		9816063	103074	0	None	4	6	Rat	7.2	pKi	=	7.2	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		CHEMBL30739	103074	0	None	4	6	Rat	7.2	pKi	=	7.2	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	232	1	1	2	3.6	Cc1sc(C)c2c1CCCC2c1c[nH]cn1	10.1021/jm000128r
		16090625	82430	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2cccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL217452	82430	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1nc2cccc(C)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		130442480	175270	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		155556618	174477	0	None	-6456	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		CHEMBL4554295	174477	0	None	-6456	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
		4011	82408	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		28417	40039	49	None	-1	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	40039	49	None	-1	12	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		26987	949	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	-158	21	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		16215415	187332	1	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		CHEMBL493091	187332	1	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MK912 from human cloned adrenergic alpha-2a receptorDisplacement of [3H]MK912 from human cloned adrenergic alpha-2a receptor	ChEMBL	471	9	2	3	3.8	CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br	10.1021/np800339e
		44330621	4402	0	None	-6	2	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	483	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(Cl)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL101411	4402	0	None	-6	2	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	483	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(Cl)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		90644738	112733	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	281	2	2	2	3.1	c1coc(C2CN/C(=N/c3ccc4c(c3)CCCC4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289548	112733	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	281	2	2	2	3.1	c1coc(C2CN/C(=N/c3ccc4c(c3)CCCC4)N2)c1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304843	112733	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	281	2	2	2	3.1	c1coc(C2CN/C(=N/c3ccc4c(c3)CCCC4)N2)c1	10.1016/j.ejmech.2014.05.057
		155526672	171209	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	528	7	0	6	6.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3c(Cl)cc(Cl)cc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4459403	171209	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	528	7	0	6	6.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3c(Cl)cc(Cl)cc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		155535203	172041	0	None	-18	6	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		CHEMBL4471712	172041	0	None	-18	6	Human	5.2	pKi	=	5.2	Binding	Inhibition of alpha2a receptor (unknown origin)Inhibition of alpha2a receptor (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
		10198108	208205	2	None	7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	200	0	1	2	1.9	Cc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		CHEMBL98471	208205	2	None	7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	200	0	1	2	1.9	Cc1ccc2c(c1)CC1(CC2)CN=CN1	10.1021/jm00020a021
		12575	1988	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm800250z
		54459	1988	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm800250z
		CHEMBL10316	1988	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1021/jm800250z
		12575	1988	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmc.2012.02.016
		54459	1988	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmc.2012.02.016
		CHEMBL10316	1988	30	None	-5	17	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmc.2012.02.016
		12774559	189609	0	None	-	1	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		CHEMBL51479	189609	0	None	-	1	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	191	3	3	4	0.8	Oc1cccc(NCC2=NCCN2)c1	10.1021/jm00366a022
		185076	187090	5	None	2	7	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		CHEMBL49137	187090	5	None	2	7	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	227	1	2	5	1.3	Cc1c(NC2=NCCN2)ccc2nccnc12	10.1016/0960-894X(95)00391-6
		213041	17133	28	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	230	2	1	1	3.0	CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1	10.1021/jm1006269
		CHEMBL1255582	17133	28	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting	ChEMBL	230	2	1	1	3.0	CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1	10.1021/jm1006269
		102	4127	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		3659	4127	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		8969	4127	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		CHEMBL15245	4127	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		DB01392	4127	48	None	-5	49	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00019a001
		155513073	169715	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	440	8	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(Cc3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4438158	169715	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	440	8	0	6	4.0	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(Cc3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		11412944	101509	69	None	223	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL298004	101509	69	None	223	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	197	1	1	3	1.1	Clc1cccnc1N1CCNCC1	10.1021/jm00366a007
		135545454	78943	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	448	7	1	7	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112983	78943	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	448	7	1	7	3.2	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		2803	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		516	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		704	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		CHEMBL134	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		DB00575	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/0960-894X(94)85032-1
		13123533	194909	1	None	-	1	Bovine	7.2	pKi	=	7.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		CHEMBL541208	194909	1	None	-	1	Bovine	7.2	pKi	=	7.2	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	271	4	1	3	3.1	Cc1ccc(N(CC2=NCCN2)C2CCCCC2)cc1	10.1021/jm00366a022
		155544935	173417	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	460	7	0	6	4.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4528557	173417	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	460	7	0	6	4.6	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccccc3Cl)C(=O)C21	10.1021/acs.jmedchem.9b02080
		162654541	180613	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	499	10	5	11	0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		CHEMBL4754656	180613	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assayDisplacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay	ChEMBL	499	10	5	11	0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCNCC2Cc3ccccc3CN2)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.0c01475
		10045713	166105	0	None	-309	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	386	3	1	4	5.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C	10.1021/jm060262x
		CHEMBL425983	166105	0	None	-309	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	386	3	1	4	5.3	Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C	10.1021/jm060262x
		122186880	122980	0	None	-7	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to alpha2A adrenoceptor (unknown origin)Binding affinity to alpha2A adrenoceptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		CHEMBL3608450	122980	0	None	-7	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to alpha2A adrenoceptor (unknown origin)Binding affinity to alpha2A adrenoceptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
		44401106	124327	0	None	-112	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL363581	124327	0	None	-112	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		57345627	71182	0	None	8	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	230	4	1	3	2.5	C=C(C)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956194	71182	0	None	8	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	230	4	1	3	2.5	C=C(C)c1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		44269089	97005	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	3	2.6	CC(Oc1ccccc1C(C)C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL266613	97005	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	232	4	1	3	2.6	CC(Oc1ccccc1C(C)C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		16757182	153251	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL397753	153251	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		16757182	153251	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL397753	153251	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		11183468	109872	2	None	-1	5	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	213	1	2	2	2.5	Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL323402	109872	2	None	-1	5	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	213	1	2	2	2.5	Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		4567175	82476	5	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	318	3	1	4	3.7	CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1	10.1021/jm060262x
		CHEMBL217665	82476	5	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	318	3	1	4	3.7	CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1	10.1021/jm060262x
		24906201	187353	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		CHEMBL493272	187353	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	280	2	1	4	2.5	c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1	10.1021/jm800250z
		1016	3747	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-12	35	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		3157	1470	71	None	-61	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		7170	1470	71	None	-61	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		954	1470	71	None	-61	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		CHEMBL707	1470	71	None	-61	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		DB00590	1470	71	None	-61	10	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1021/jm00018a001
		56964693	74062	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	314	0	1	5	2.8	Clc1ccc2c(c1)N=C(N1CCNCC1)c1cccnc1O2	10.1021/jm2013419
		CHEMBL2022269	74062	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation countingDisplacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting	ChEMBL	314	0	1	5	2.8	Clc1ccc2c(c1)N=C(N1CCNCC1)c1cccnc1O2	10.1021/jm2013419
		12841596	117460	20	None	3	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligandBinding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligand	ChEMBL	237	1	1	5	0.8	Clc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL2448004	117460	20	None	3	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligandBinding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligand	ChEMBL	237	1	1	5	0.8	Clc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		CHEMBL339883	117460	20	None	3	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligandBinding affinity against alpha-2 adrenergic receptor was determined in calf cerebral cortex homogenates using [3H]clonidine as radioligand	ChEMBL	237	1	1	5	0.8	Clc1cn2ccnc2c(N2CCNCC2)n1	10.1021/jm00099a012
		12909383	130703	1	None	-5	2	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	278	0	0	2	3.6	CN1CCC(=C2c3ccccc3CCn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL368413	130703	1	None	-5	2	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	278	0	0	2	3.6	CN1CCC(=C2c3ccccc3CCn3cccc32)CC1	10.1021/jm00361a008
		44292470	101635	5	None	57	2	Bovine	7.1	pKi	=	7.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	1	3	1.5	Cc1ccnc(N2CCNCC2)c1Cl	10.1021/jm00366a007
		CHEMBL299007	101635	5	None	57	2	Bovine	7.1	pKi	=	7.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	211	1	1	3	1.5	Cc1ccnc(N2CCNCC2)c1Cl	10.1021/jm00366a007
		136044137	78937	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	472	6	1	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112976	78937	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	472	6	1	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CN2	10.1021/jm049619s
		25130235	187587	1	None	-2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		CHEMBL494678	187587	1	None	-2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
		15675860	204429	0	None	4	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		CHEMBL72147	204429	0	None	4	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscineBinding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine	ChEMBL	305	1	2	5	2.1	Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1	10.1016/0960-894X(95)00391-6
		23622576	172772	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
		CHEMBL451229	172772	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	272	4	1	3	3.5	CC(Oc1ccccc1C1CCCCC1)C1=NCCN1	10.1021/jm800250z
		3823	50221	42	None	-40	10	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	50221	42	None	-40	10	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	50221	42	None	-40	10	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		1577	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		2537	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5355	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		5501	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		643497	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		688272	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		958	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		960	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL196677	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL26	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		CHEMBL267044	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB00391	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		DB16021	3703	110	None	-3	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	nan
		10674896	206644	0	None	-416	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	588	9	2	6	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1	10.1021/jm980077m
		CHEMBL89243	206644	0	None	-416	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	588	9	2	6	6.4	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1	10.1021/jm980077m
		657255	199084	34	None	-10	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	199084	34	None	-10	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		155567867	176033	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	502	8	0	6	5.7	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4590209	176033	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	502	8	0	6	5.7	CCOP(=O)(OCC)C1(c2ccccc2)N=CC2C(=O)N(c3ccc(-c4ccccc4)cc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		10454026	17907	0	None	-234	9	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		CHEMBL125916	17907	0	None	-234	9	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		10895039	18520	0	None	-154	8	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL127400	18520	0	None	-154	8	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL129022	18520	0	None	-154	8	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		10655607	204755	5	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	199	2	3	3	2.0	c1c[nH]c(Nc2ccc3[nH]cnc3c2)n1	10.1021/jm9605142
		CHEMBL74544	204755	5	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	199	2	3	3	2.0	c1c[nH]c(Nc2ccc3[nH]cnc3c2)n1	10.1021/jm9605142
		10326069	39296	1	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		CHEMBL147077	39296	1	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand.	ChEMBL	589	10	3	8	3.3	CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm980506g
		53324553	56855	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		CHEMBL1643900	56855	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		53324553	56855	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL1643900	56855	0	None	-10	10	Human	5.1	pKi	=	5.1	Binding	Inhibition of alpha2A adrenergic receptorInhibition of alpha2A adrenergic receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		1210	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	918	51	None	-416	21	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		72947314	92490	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.0	c1ccc(OCC2=NCCN2)c(CC2CC2)c1	10.1021/ml400232p
		CHEMBL2431281	92490	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	230	5	1	3	2.0	c1ccc(OCC2=NCCN2)c(CC2CC2)c1	10.1021/ml400232p
		490	191	8	None	-389	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		9890547	191	8	None	-389	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		CHEMBL268758	191	8	None	-389	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		12909389	60369	0	None	-64	2	Bovine	4.1	pKi	=	4.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	320	1	1	3	3.7	CN1CCC(=C2c3cc(C(=O)O)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		CHEMBL174649	60369	0	None	-64	2	Bovine	4.1	pKi	=	4.1	Binding	Displacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortexDisplacement of [3H]- clonidine radioligand binding at the alpha-2 adrenergic receptor binding site of calf cerebral cortex	ChEMBL	320	1	1	3	3.7	CN1CCC(=C2c3cc(C(=O)O)ccc3C=Cn3cccc32)CC1	10.1021/jm00361a008
		16090598	82455	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		CHEMBL217568	82455	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	394	3	1	4	5.4	Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C	10.1021/jm060262x
		5467	205928	43	None	-6	5	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		CHEMBL84158	205928	43	None	-6	5	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	nan
		44288847	165309	0	None	-5495	5	Human	5.1	pKi	=	5.1	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	535	7	2	5	3.9	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		CHEMBL42335	165309	0	None	-5495	5	Human	5.1	pKi	=	5.1	Binding	In vivo inhibitory effect against Alpha-2A adrenergic receptorIn vivo inhibitory effect against Alpha-2A adrenergic receptor	ChEMBL	535	7	2	5	3.9	CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1	10.1016/s0960-894x(99)00696-4
		5897	105211	80	None	-7	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		CHEMBL311469	105211	80	None	-7	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
		44401164	69816	0	None	-346	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-346	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		90644744	112741	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	205	3	2	2	1.3	CCOc1ccc(N=C2NCCN2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289551	112741	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	205	3	2	2	1.3	CCOc1ccc(N=C2NCCN2)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304991	112741	2	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	205	3	2	2	1.3	CCOc1ccc(N=C2NCCN2)cc1	10.1016/j.ejmech.2014.05.057
		16090623	82454	0	None	-102	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		CHEMBL217567	82454	0	None	-102	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		44415690	80137	0	None	-363	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213336	80137	0	None	-363	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		10923927	204178	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	279	3	2	5	0.8	O=S1(=O)CCCc2cccc(NCC3=NCCN3)c21	10.1021/jm000542r
		CHEMBL70740	204178	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	279	3	2	5	0.8	O=S1(=O)CCCc2cccc(NCC3=NCCN3)c21	10.1021/jm000542r
		6604789	101047	5	None	-31	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL294649	101047	5	None	-31	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity against Alpha-2A adrenergic receptorBinding affinity against Alpha-2A adrenergic receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		57399991	71248	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2CO[C@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		CHEMBL1956901	71248	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting	ChEMBL	232	2	1	4	1.1	c1ccc([C@H]2CO[C@H](C3=NCCN3)CO2)cc1	10.1016/j.bmc.2012.02.016
		12575	1988	30	None	-5	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmcl.2006.12.094
		54459	1988	30	None	-5	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmcl.2006.12.094
		CHEMBL10316	1988	30	None	-5	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	10.1016/j.bmcl.2006.12.094
		134987	186681	47	None	309	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	181	1	1	3	0.6	Fc1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL48833	186681	47	None	309	2	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	181	1	1	3	0.6	Fc1cccnc1N1CCNCC1	10.1021/jm00366a007
		441975	16451	56	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		CHEMBL123325	16451	56	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	352	1	1	4	3.2	COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12	10.1021/jm00019a001
		49864359	15626	0	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	467	10	1	5	4.1	COc1ccccc1N1CCN(CCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		CHEMBL1221592	15626	0	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MK912 from human alpha2A receptor after 60 minsDisplacement of [3H]MK912 from human alpha2A receptor after 60 mins	ChEMBL	467	10	1	5	4.1	COc1ccccc1N1CCN(CCCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.07.002
		124	2981	47	None	-4	33	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2032	2981	47	None	-4	33	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		4636	2981	47	None	-4	33	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		CHEMBL762	2981	47	None	-4	33	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		DB00935	2981	47	None	-4	33	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
		2803	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		516	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		704	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		CHEMBL134	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		DB00575	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1016/j.bmc.2012.06.008
		10775000	107394	2	None	-2	4	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	214	1	2	2	2.6	Oc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL317912	107394	2	None	-2	4	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	214	1	2	2	2.6	Oc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		44324765	111568	0	None	-2	5	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL328114	111568	0	None	-2	5	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		9846548	207325	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL93489	207325	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	449	7	0	7	3.1	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		1212	1662	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-165	65	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		9960497	100476	0	None	-2454	6	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		CHEMBL290860	100476	0	None	-2454	6	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.9	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1	10.1021/jm00010a001
		16090628	141787	0	None	-933	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	4	1	4	5.3	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(N2CCCN(C)CC2)cc1	10.1021/jm060262x
		CHEMBL386169	141787	0	None	-933	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	4	1	4	5.3	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(N2CCCN(C)CC2)cc1	10.1021/jm060262x
		44574075	172576	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL448802	172576	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	251	2	0	4	2.9	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
		4601	206747	35	None	-2	16	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-2	16	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-2	16	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		10466448	112883	2	None	34	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	0	5	0.8	Cc1cnc(N2CCN(C)CC2)c2nccn12	10.1021/jm00099a012
		CHEMBL330994	112883	2	None	34	2	Bovine	7.1	pKi	=	7.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	231	1	0	5	0.8	Cc1cnc(N2CCN(C)CC2)c2nccn12	10.1021/jm00099a012
		44579229	189616	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		CHEMBL514837	189616	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	468	10	1	7	2.8	CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1	10.1016/j.bmcl.2008.08.055
		11000184	13052	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL1190038	13052	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL540035	13052	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		10859076	13682	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL1194763	13682	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL553276	13682	0	None	-1	6	Human	7.1	pKi	=	7.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
		127036932	137348	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3752900	137348	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
		16757089	92291	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		CHEMBL242693	92291	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm061487a
		16757089	92291	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL242693	92291	1	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	311	5	1	5	3.0	C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1	10.1021/jm100977d
		11448533	84691	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	0	3	3.6	CC(Oc1ccccc1-c1ccccc1)C1=NCCO1	10.1021/jm0408215
		CHEMBL222591	84691	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	267	4	0	3	3.6	CC(Oc1ccccc1-c1ccccc1)C1=NCCO1	10.1021/jm0408215
		11473729	84692	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	0	2	4.4	CC(Oc1ccccc1-c1ccccc1)C1=NCCC1	10.1021/jm0408215
		CHEMBL222593	84692	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	0	2	4.4	CC(Oc1ccccc1-c1ccccc1)C1=NCCC1	10.1021/jm0408215
		136680386	207703	0	None	-169	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	680	16	4	8	4.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1	10.1016/s0960-894x(99)00484-9
		44328801	207703	0	None	-169	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	680	16	4	8	4.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL95578	207703	0	None	-169	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	680	16	4	8	4.6	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1	10.1016/s0960-894x(99)00484-9
		491	192	9	None	-524	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		9891167	192	9	None	-524	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		CHEMBL13856	192	9	None	-524	12	Human	7.1	pKi	=	7.1	Binding	Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptorAncillary Binding affinity towards cloned human Alpha-2A adrenergic receptor	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		1530	2182	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-70	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3038495	708	37	None	-56	19	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		7625	708	37	None	-56	19	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		CHEMBL25236	708	37	None	-56	19	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		57345629	71185	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1021/ml400232p
		CHEMBL1956197	71185	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1021/ml400232p
		127036953	137515	0	None	-8	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		CHEMBL3754166	137515	0	None	-8	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2A adrenergic receptor (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
		44269140	33553	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	248	5	1	4	2.2	CC(C)Oc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL14208	33553	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	248	5	1	4	2.2	CC(C)Oc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		57345629	71185	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956197	71185	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	246	5	1	4	2.0	CC(Oc1ccccc1OC1CC1)C1=NCCN1	10.1016/j.bmc.2012.01.035
		9817231	158236	22	None	1	7	Human	5.1	pKi	=	5.1	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		CHEMBL4088272	158236	22	None	1	7	Human	5.1	pKi	=	5.1	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		90644755	112728	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	5	4	2	2.5	CCCNC(=N)Nc1ccc(NCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3289538	112728	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	5	4	2	2.5	CCCNC(=N)Nc1ccc(NCC)cc1	10.1016/j.ejmech.2014.05.057
		CHEMBL3304668	112728	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysisDisplacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric analysis	ChEMBL	220	5	4	2	2.5	CCCNC(=N)Nc1ccc(NCC)cc1	10.1016/j.ejmech.2014.05.057
		10044968	96545	0	None	-54	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL262901	96545	0	None	-54	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		56852956	112043	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL4642079	214023	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		Cc1c(N2CCNCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl	10.6019/CHEMBL4630901
		9904606	9386	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	3	1	3	2.3	CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O	10.1021/jm030551a
		CHEMBL111463	9386	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	305	3	1	3	2.3	CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O	10.1021/jm030551a
		16090594	82125	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		CHEMBL216674	82125	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	388	3	1	4	5.4	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@@H](C)C4)cc3)c(C)c(C)nc2c1C	10.1021/jm060262x
		56852956	112043	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289656	112043	1	None	-218	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL4642079	214023	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	GPCRScan assay: inhibition of Alpha2AGPCRScan assay: inhibition of Alpha2A	ChEMBL		None	None	None		Cc1c(N2CCNCC2)nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(=O)O)c1ccccc1Cl	10.6019/CHEMBL4630901
		2803	955	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		516	955	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		704	955	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		CHEMBL134	955	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		DB00575	955	58	None	-1	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Alpha-2A adrenergic receptorBinding affinity towards Alpha-2A adrenergic receptor	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm990569e
		2803	955	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		516	955	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		704	955	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		CHEMBL134	955	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		DB00575	955	58	None	1	19	Rat	6.1	pKi	=	6.1	Binding	in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1021/jm000128r
		237	204865	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	204865	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	204865	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	204865	48	None	-1	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		11293787	148213	0	None	-77	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		CHEMBL393597	148213	0	None	-77	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsDisplacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells	ChEMBL	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	10.1016/j.bmcl.2006.12.094
		155552185	174061	0	None	-1548	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4544086	174061	0	None	-1548	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)Displacement of [3H] RX821002 from alpha2A adrenergic receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		44582676	189779	0	None	-6	17	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned alpha2A adrenergic receptor by competitive binding experimentInhibition of human cloned alpha2A adrenergic receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	189779	0	None	-6	17	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned alpha2A adrenergic receptor by competitive binding experimentInhibition of human cloned alpha2A adrenergic receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		10398419	116641	0	None	13	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CCC1(CN=CN1)C2	10.1021/jm00020a021
		CHEMBL336970	116641	0	None	13	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligandBinding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]RX-821002 as radioligand	ChEMBL	216	1	1	3	1.6	COc1ccc2c(c1)CCC1(CN=CN1)C2	10.1021/jm00020a021
		136019934	144530	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		CHEMBL390718	144530	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	462	7	1	7	3.6	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2	10.1016/j.bmc.2007.03.053
		44350063	117948	0	None	-	1	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	349	4	3	7	-0.0	C1=CN2CCN=C2C(N2CCNCC2)=N1.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		CHEMBL340358	117948	0	None	-	1	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.	ChEMBL	349	4	3	7	-0.0	C1=CN2CCN=C2C(N2CCNCC2)=N1.O=C(O)C/C=C\CC(=O)O	10.1021/jm00099a012
		11058166	204705	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL74114	204705	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1	10.1021/jm000542r
		9931977	63040	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		CHEMBL1788223	63040	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosinCompound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin	ChEMBL	421	4	0	7	3.3	COc1ccccc1N1CCN(C[C@H]2CN=C3c4ccccc4N=C(SC)N32)CC1	10.1021/jm970159v
		132060763	162861	0	None	-3	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	5	0	4	4.1	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4173095	162861	0	None	-3	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method	ChEMBL	405	5	0	4	4.1	C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
		44415593	80247	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213834	80247	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity at adrenergic alpha2A receptorBinding affinity at adrenergic alpha2A receptor	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11732785	163720	0	None	-102	6	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		CHEMBL420510	163720	0	None	-102	6	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 bindingBinding affinity for rat cortex Alpha-2 adrenergic receptor was determined using [3H]-RX 81002 binding	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		10473701	83238	0	None	-165	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	3	1	4	4.8	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)(C)C2)cc1	10.1021/jm060262x
		CHEMBL218679	83238	0	None	-165	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	360	3	1	4	4.8	Cc1cnc2ccccc2c1Nc1ccc(N2CCN(C)C(C)(C)C2)cc1	10.1021/jm060262x
		44424855	85454	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		CHEMBL226636	85454	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic alpha2A receptor transfected in CHO cells	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2	10.1016/j.bmc.2007.03.053
		44330609	163452	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL419894	163452	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	467	7	0	7	3.3	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(F)cc4)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		135405894	78930	0	None	-5	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	470	8	1	8	2.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(CCOc4ccc(F)cc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		CHEMBL2112969	78930	0	None	-5	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity for alpha-2A adrenergic receptorBinding affinity for alpha-2A adrenergic receptor	ChEMBL	470	8	1	8	2.7	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(CCOc4ccc(F)cc4)CC3)[C@@H]1CN2	10.1021/jm049619s
		10028898	111655	0	None	-11	2	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		CHEMBL328631	111655	0	None	-11	2	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity to the human alpha-2A adrenergic receptorIn vitro binding affinity to the human alpha-2A adrenergic receptor	ChEMBL	499	7	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4F)CC3)[C@@H]1CO2	10.1016/j.bmcl.2004.03.031
		123981	16459	22	None	-2	8	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	10.1021/jm00019a001
		CHEMBL123349	16459	22	None	-2	8	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	10.1021/jm00019a001
		CHEMBL536803	16459	22	None	-2	8	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	ChEMBL	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	10.1021/jm00019a001
		9816048	187278	0	None	12	3	Human	8.0	pKi	=	8.0	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	231	1	4	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCN2	10.1021/jm960359r
		CHEMBL49284	187278	0	None	12	3	Human	8.0	pKi	=	8.0	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	ChEMBL	231	1	4	5	1.2	Cc1c(NC2=NCCN2)ccc2c1NCCN2	10.1021/jm960359r
		463	1405	22	None	-67	12	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		6918097	1405	22	None	-67	12	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		837	1405	22	None	-67	12	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		CHEMBL2051956	1405	22	None	-67	12	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		DB14068	1405	22	None	-67	12	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.1021/jm00010a001
		16090627	81567	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	9	2	4	5.9	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(NCCN(CC)CC)cc1	10.1021/jm060262x
		CHEMBL216197	81567	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	390	9	2	4	5.9	CCc1c(C)nc2c(C)cccc2c1Nc1ccc(NCCN(CC)CC)cc1	10.1021/jm060262x
		2683	102888	25	None	-12	16	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	102888	25	None	-12	16	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	102888	25	None	-12	16	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		10333157	151238	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		CHEMBL396013	151238	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm061487a
		11140033	20683	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		CHEMBL130884	20683	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	265	4	2	3	3.2	CC(Nc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm0408215
		10333157	151238	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		CHEMBL396013	151238	0	None	3	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	266	4	1	3	3.1	C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1	10.1021/jm100977d
		16090595	141401	0	None	-109	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		CHEMBL383978	141401	0	None	-109	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	374	3	1	4	5.0	Cc1ccc2c(Nc3ccc(N4CCN(C)[C@H](C)C4)cc3)c(C)c(C)nc2c1	10.1021/jm060262x
		10651654	111483	0	None	-489	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	631	9	2	5	7.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1	10.1021/jm980077m
		CHEMBL327712	111483	0	None	-489	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	631	9	2	5	7.8	CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1	10.1021/jm980077m
		10084076	97916	0	None	-5	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
		CHEMBL27251	97916	0	None	-5	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards Alpha-2 adrenergic receptorBinding affinity towards Alpha-2 adrenergic receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
		44324737	207238	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL92860	207238	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	473	6	0	7	3.8	COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2	10.1016/s0960-894x(03)00525-0
		44568614	187623	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	252	4	1	3	2.8	c1ccc(OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		CHEMBL494885	187623	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells	ChEMBL	252	4	1	3	2.8	c1ccc(OC(C2=NCCN2)c2ccccc2)cc1	10.1021/jm800250z
		2337	3256	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-50	62	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5280805	85405	81	None	-28	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	10.1021/np1000329
		CHEMBL226335	85405	81	None	-28	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	ChEMBL	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	10.1021/np1000329
		25110718	193309	0	None	-72	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		CHEMBL524153	193309	0	None	-72	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic alpha2A receptor expressed in CHO cells by radioligand binding assay	ChEMBL	488	8	1	7	3.5	O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1	10.1016/j.bmcl.2008.08.055
		10527469	156265	3	None	-204	15	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		CHEMBL40650	156265	3	None	-204	15	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		164609730	185099	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	398	2	1	5	3.5	CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		CHEMBL4856060	185099	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of alpha2a adrenergic receptor (unknown origin)Inhibition of alpha2a adrenergic receptor (unknown origin)	ChEMBL	398	2	1	5	3.5	CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
		71463022	83698	7	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	436	8	0	5	5.3	COc1cc2oc(C(=O)N(CCCN3CCCCC3)c3ccccc3)c(C)c2cc1OC	10.1016/j.bmc.2012.09.044
		CHEMBL2205362	83698	7	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2A adrenergic receptor after 40 mins by scintillation counting analysis	ChEMBL	436	8	0	5	5.3	COc1cc2oc(C(=O)N(CCCN3CCCCC3)c3ccccc3)c(C)c2cc1OC	10.1016/j.bmc.2012.09.044
		24841480	183899	0	None	-47	20	Human	7.0	pKi	=	7.0	Binding	Antagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	183899	0	None	-47	20	Human	7.0	pKi	=	7.0	Binding	Antagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha2A receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		10489502	4518	2	None	6	3	Human	7.0	pKi	=	7.0	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	2	2	2	3.5	Clc1cccc(Cl)c1Nc1ncc[nH]1	10.1021/jm9605142
		CHEMBL1022	4518	2	None	6	3	Human	7.0	pKi	=	7.0	Binding	Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cells	ChEMBL	227	2	2	2	3.5	Clc1cccc(Cl)c1Nc1ncc[nH]1	10.1021/jm9605142
		28918670	92487	2	None	4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	254	3	1	3	1.8	Brc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		CHEMBL2431279	92487	2	None	4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human alpha2A ARBinding affinity at human alpha2A AR	ChEMBL	254	3	1	3	1.8	Brc1ccccc1OCC1=NCCN1	10.1021/ml400232p
		10508132	107017	0	None	-16	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	10	2	6	5.5	CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1	10.1021/jm980077m
		CHEMBL315392	107017	0	None	-16	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	621	10	2	6	5.5	CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1	10.1021/jm980077m
		10507651	206507	0	None	-107	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	591	9	2	6	5.8	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		CHEMBL88388	206507	0	None	-107	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptorBinding affinity determined by displacement of [3H]rauwolscine from alpha-2A adrenergic receptor	ChEMBL	591	9	2	6	5.8	CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2	10.1021/jm980077m
		9950711	109206	0	None	-5	3	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	359	4	2	3	3.2	O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL321644	109206	0	None	-5	3	Human	6.0	pKi	=	6.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	359	4	2	3	3.2	O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1	10.1021/jm030551a
		14004033	49232	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL156283	49232	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorCompound was evaluated for log 1/Ki at alpha-2 adrenergic receptor	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		78114671	174164	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	350	6	0	6	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		CHEMBL4546903	174164	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryDisplacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry	ChEMBL	350	6	0	6	2.5	CCOP(=O)(OCC)C1N=CC2C(=O)N(c3ccccc3)C(=O)C21	10.1021/acs.jmedchem.9b02080
		44328654	107185	0	None	-251	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	663	14	3	6	6.7	CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL316495	107185	0	None	-251	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	663	14	3	6	6.7	CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1	10.1016/s0960-894x(99)00484-9
		21830793	91835	10	None	-630	45	Human	7.0	pKi	=	7.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		CHEMBL2413154	91835	10	None	-630	45	Human	7.0	pKi	=	7.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
		139406787	177145	0	None	2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	492	5	2	5	5.8	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1	10.1021/acs.jmedchem.0c00745
		CHEMBL4633982	177145	0	None	2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adrenergic alpha2A receptor (unknown origin)Binding affinity to adrenergic alpha2A receptor (unknown origin)	ChEMBL	492	5	2	5	5.8	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1	10.1021/acs.jmedchem.0c00745
		10251036	81885	0	None	-162	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	410	4	2	5	4.7	CN1CCN(c2ccc(Nc3c(CO)cnc4cc(Cl)ccc34)cc2)CC1(C)C	10.1021/jm060262x
		CHEMBL216464	81885	0	None	-162	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	410	4	2	5	4.7	CN1CCN(c2ccc(Nc3c(CO)cnc4cc(Cl)ccc34)cc2)CC1(C)C	10.1021/jm060262x
		14004033	49232	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		CHEMBL156283	49232	5	None	2	2	Bovine	5.0	pKi	=	5.0	Binding	Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranesAffinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes	ChEMBL	177	0	1	2	1.5	c1[nH]nc2c1CCN1CCCCC21	10.1021/jm00398a025
		16090632	141716	0	None	-46	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	348	4	3	5	3.3	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1	10.1021/jm060262x
		CHEMBL385722	141716	0	None	-46	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	348	4	3	5	3.3	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1	10.1021/jm060262x
		2777786	174977	82	None	29	2	Bovine	7.0	pKi	=	7.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.5	FC(F)(F)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		CHEMBL45663	174977	82	None	29	2	Bovine	7.0	pKi	=	7.0	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	ChEMBL	231	1	1	3	1.5	FC(F)(F)c1cccnc1N1CCNCC1	10.1021/jm00366a007
		57399145	71184	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	234	5	1	4	1.9	CCOc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		CHEMBL1956196	71184	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	ChEMBL	234	5	1	4	1.9	CCOc1ccccc1OC(C)C1=NCCN1	10.1016/j.bmc.2012.01.035
		49836307	18785	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		CHEMBL1278085	18785	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells	ChEMBL	282	4	2	4	2.8	C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1	10.1021/jm100977d
		9879119	9446	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	4	2	3	2.2	CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1	10.1021/jm030551a
		CHEMBL111771	9446	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assayIn vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay	ChEMBL	291	4	2	3	2.2	CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1	10.1021/jm030551a
		11747739	13235	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL1191324	13235	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		CHEMBL542402	13235	0	None	-1	4	Human	6.0	pKi	=	6.0	Binding	Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
		44324860	207498	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cc5ccccc5s4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		CHEMBL94435	207498	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine	ChEMBL	479	6	0	8	3.8	COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cc5ccccc5s4)CC3)C1CO2	10.1016/s0960-894x(03)00525-0
		16090633	80461	0	None	-25	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		CHEMBL214661	80461	0	None	-25	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL	380	4	2	5	3.8	C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccc(F)cc34)cc2)CCN1C	10.1021/jm060262x
		4209	3163	75	None	-3235	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		4893	3163	75	None	-3235	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		503	3163	75	None	-3235	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		5385	3163	75	None	-3235	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		CHEMBL2	3163	75	None	-3235	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		DB00457	3163	75	None	-3235	33	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
		44329026	208425	0	None	-19	6	Human	7.0	pKi	=	7	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	679	16	3	7	6.1	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1	10.1016/s0960-894x(99)00484-9
		CHEMBL99864	208425	0	None	-19	6	Human	7.0	pKi	=	7	Binding	Binding affinity against human Alpha-2a adrenergic receptorBinding affinity against human Alpha-2a adrenergic receptor	ChEMBL	679	16	3	7	6.1	CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1	10.1016/s0960-894x(99)00484-9
		2105	3054	37	None	-58	33	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	3054	37	None	-58	33	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	3054	37	None	-58	33	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	3054	37	None	-58	33	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	3054	37	None	-58	33	Human	7.0	pKi	=	7	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		44574078	178761	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		CHEMBL468711	178761	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of adrenergic alpha2A receptorInhibition of adrenergic alpha2A receptor	ChEMBL	261	2	0	3	3.3	c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
		168274641	190435	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2ccc(O)cc2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		CHEMBL5178192	190435	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assayDisplacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive binding assay	ChEMBL	266	1	2	3	3.3	O=C1/C(=C/c2ccc(O)cc2)CCc2c(O)cccc21	10.1016/j.ejmech.2021.113964
		2477	745	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	None	-	29	Bovine	8.3	pIC50	=	8.3	Binding	Binding affinity against alpha-2 adrenergic receptor in calf frontal cortexBinding affinity against alpha-2 adrenergic receptor in calf frontal cortex	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		3689	102771	55	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandCompound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		CHEMBL1372983	102771	55	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandCompound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		CHEMBL305187	102771	55	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandCompound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand	Drug Central	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	None
		2803	955	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	None	-	19	Bovine	8.1	pIC50	=	8.1	Binding	Concentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uMConcentration necessary to achieve half maximal inhibition of [3H]clonidine binding to Alpha-2 adrenergic receptor at 1 uM	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		3294	2006	111	None	-	45	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-	45	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-	45	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-	45	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-	45	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandBinding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1795	1591	64	None	-	1	Human	1.8	pKd	=	1.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	299	4	3	5	0.4	CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C	1325028
		4186	1591	64	None	-	1	Human	1.8	pKd	=	1.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	299	4	3	5	0.4	CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C	1325028
		CHEMBL517986	1591	64	None	-	1	Human	1.8	pKd	=	1.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	299	4	3	5	0.4	CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C	1325028
		1192	147	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	1325028
		1192	147	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	9584219
		1794	147	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	1325028
		1794	147	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	9584219
		CHEMBL501701	147	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	1325028
		CHEMBL501701	147	47	None	-51286	17	Human	2.5	pKd	=	2.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	9584219
		108094	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		108094	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		108094	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		526	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		526	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		526	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		528	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		528	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		528	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		CHEMBL10332	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		CHEMBL10332	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7908642
		CHEMBL10332	3423	27	None	-1	4	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	8819505
		136	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		136	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		136	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		223	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		223	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		223	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		643606	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		643606	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		643606	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		CHEMBL10347	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		CHEMBL10347	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		CHEMBL10347	3292	32	None	-3	15	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8819505
		2435	722	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		395	722	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		520	722	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		5386	722	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		CHEMBL844	722	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		DB00484	722	100	None	-2	12	Human	9.1	pKd	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	2865672
		1588	2325	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-RX821002	1	44	Human	10.3	pKi	=	10.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL1196898	216030	0	3H-RAUWOLSCINE	1	3	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	248	3	1	5	1.2	CCOC1(COC2=CC=CC=C2O1)C3=NCCN3	None
		2601	3780	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	3H-RX821002	-1	21	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		138107169	215952	0	3H-RAUWOLSCINE	-6	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-RAUWOLSCINE	-6	22	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		12576	514	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		71310	514	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		CHEMBL353972	514	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		DB11481	514	94	3H-RAUWOLSCINE	-2	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	None
		108094	3423	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	3423	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	3423	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	3423	27	35S-GTPGammaS	-1	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		None	216029	0	3H-RAUWOLSCINE	-2	3	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	953	28	10	12	0.9	CCOC1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C=S)C(=O)NC(CCCCN)C(=O)N)NC(=O)CC3(CCCCC3)S	None
		138107169	215952	0	3H-RX821002	1	22	Pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-RX821002	1	22	Pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	216028	0	3H-RAUWOLSCINE	-13	3	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	339	0	0	3	3.3	CN1CCC2(CCN3CCC4=C(C3C2)OC5=CC=CC=C45)N(C1=O)C	None
		138107169	215952	0	3H-RAUWOLSCINE	-6	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-RAUWOLSCINE	-6	22	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		102	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		108094	3423	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		108094	3423	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	3423	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	3423	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	3423	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	3423	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	3423	27	3H-MK912	-1	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	3423	27	35S-GTPGammaS	1	4	Mouse	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		102	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-RAUWOLSCINE	-5	49	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		164512323	216031	0	3H-RAUWOLSCINE	-5	5	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RAUWOLSCINE	-5	5	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		124	2981	47	3H-RAUWOLSCINE	-4	33	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-RAUWOLSCINE	-4	33	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-RAUWOLSCINE	-4	33	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-RAUWOLSCINE	-4	33	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-RAUWOLSCINE	-4	33	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		None	215958	0	3H-RAUWOLSCINE	-14	19	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		108094	3423	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	3423	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	3423	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	3423	27	3H-RAUWOLSCINE	-1	4	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		None	215961	0	3H-RAUWOLSCINE	-1	5	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	295	5	2	3	3.0	C1CC2=CC=CC=C2C(=O)C1CNCCC3=CC=C(C=C3)O	None
		None	215958	0	3H-RX821002	-6	19	Pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		108094	3423	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		526	3423	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		528	3423	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		CHEMBL10332	3423	27	3H-MK912	-1	4	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	None
		138107169	215952	0	35S-GTPGammaS	-6	22	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	35S-GTPGammaS	-6	22	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	215958	0	3H-RAUWOLSCINE	-14	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		41	1659	0	3H-PRAZOSIN	-1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	1659	0	3H-PRAZOSIN	-1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	1659	0	3H-PRAZOSIN	-1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		None	215958	0	3H-RAUWOLSCINE	-14	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		124	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	2981	47	3H-CLONIDINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-CLONIDINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-CLONIDINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-CLONIDINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-CLONIDINE	-4	33	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2142	3096	58	3H-RX821002	-2	36	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RX821002	-2	36	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RX821002	-2	36	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RX821002	-2	36	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RX821002	-2	36	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RX821002	-2	36	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		102	4127	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-RAUWOLSCINE	-5	49	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	216707	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	390	1	2	4	3.1	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl	None
		12575	1988	30	3H-RAUWOLSCINE	-5	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	1988	30	3H-RAUWOLSCINE	-5	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	1988	30	3H-RAUWOLSCINE	-5	17	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		2389	3331	118	3H-RAUWOLSCINE	-77	67	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-RAUWOLSCINE	-77	67	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-RAUWOLSCINE	-77	67	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-RAUWOLSCINE	-77	67	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-RAUWOLSCINE	-77	67	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		164512323	216031	0	3H-RX821002	-18	5	Pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RX821002	-18	5	Pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		46780481	107531	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-CLONIDINE	-47	53	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		521	1404	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		5311068	1404	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		835	1404	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		CHEMBL778	1404	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		DB00633	1404	69	None	-2	7	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	None
		31101	729	40	3H-RX821002	-10	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-RX821002	-10	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-RX821002	-10	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-RX821002	-10	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-RX821002	-10	36	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		202	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		104870	98880	47	3H-Yohimbine	-54	21	Pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	3H-Yohimbine	-54	21	Pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	3H-Yohimbine	-54	21	Pig	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5656	203066	87	UNDEFINED	-25	40	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	UNDEFINED	-25	40	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	203127	52	UNDEFINED	-1	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	UNDEFINED	-1	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		165193	215945	0	3H-RAUWOLSCINE	-4265	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	215945	0	3H-RAUWOLSCINE	-4265	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	215945	0	3H-RAUWOLSCINE	-4265	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		3075702	217332	0	3H-RAUWOLSCINE	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		1499	2091	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		1499	2091	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		3779	2091	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		3779	2091	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		536	2091	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		536	2091	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		CHEMBL434	2091	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		CHEMBL434	2091	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		DB01064	2091	47	35S-GTPGammaS	-1445	17	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		DB01064	2091	47	3H-Yohimbine	-1445	17	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
		243	3202	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	3202	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	3202	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	3202	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	3202	91	3H-RAUWOLSCINE	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		2	3261	23	3H-RX821002	-2089	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-RX821002	-2089	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-RX821002	-2089	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		183782	3398	20	3H-RAUWOLSCINE	-1737	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		237	3398	20	3H-RAUWOLSCINE	-1737	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL85251	3398	20	3H-RAUWOLSCINE	-1737	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		6917970	3691	61	3H-CLONIDINE	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-CLONIDINE	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-CLONIDINE	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		2662	11384	131	3H-CLONIDINE	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	3H-CLONIDINE	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		5090	15561	106	3H-CLONIDINE	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	3H-CLONIDINE	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		127151	35330	18	3H-RX821002	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		3022645	35330	18	3H-RX821002	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		CHEMBL14370	35330	18	3H-RX821002	-1584	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	None
		156391	46800	99	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		10624	70300	19	125I-Clonidine	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	125I-Clonidine	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	125I-Clonidine	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		2244	94233	100	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	94233	100	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		3663	99967	83	3H-CLONIDINE	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	99967	83	3H-CLONIDINE	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		446220	133521	14	3H-CLONIDINE	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	3H-CLONIDINE	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		5280343	188275	124	3H-CLONIDINE	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	188275	124	3H-CLONIDINE	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	188275	124	3H-CLONIDINE	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		3672	192533	136	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	192533	136	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	193615	112	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	193615	112	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		2771	195017	74	3H-RAUWOLSCINE	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	195017	74	3H-RX821002	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-RAUWOLSCINE	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-RX821002	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-RAUWOLSCINE	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-RX821002	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		4495	196535	92	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	200551	115	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		5281600	203025	92	3H-CLONIDINE	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	203025	92	3H-CLONIDINE	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	203066	87	3H-RX821002	-25	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-RX821002	-25	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		4054	205501	72	125I-Clonidine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	125I-Clonidine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	125I-Clonidine	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		119607	206203	113	3H-CLONIDINE	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	3H-CLONIDINE	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		None	215993	0	3H-RAUWOLSCINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		104911	216019	0	3H-CLONIDINE	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	216027	0	3H-RAUWOLSCINE	-10	12	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
		25137849	216179	0	3H-CLONIDINE	-2	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-CLONIDINE	-2	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		31404	216193	0	3H-Yohimbine	-	1	Pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	253	1	1	4	1.5	CCN1CCC2=C(CC1)OC(=N2)N.Cl.Cl	None
		None	216311	0	3H-CLONIDINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216312	0	3H-CLONIDINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216313	0	3H-CLONIDINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216314	0	3H-CLONIDINE	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216315	0	3H-CLONIDINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	216316	0	3H-CLONIDINE	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216317	0	3H-CLONIDINE	-1	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216318	0	3H-CLONIDINE	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	216327	0	3H-CLONIDINE	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	216328	0	3H-CLONIDINE	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	216329	0	3H-CLONIDINE	2	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	216331	0	3H-CLONIDINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		None	216342	0	3H-RX821002	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		135269	216389	0	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	216390	0	3H-CLONIDINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	216391	0	3H-CLONIDINE	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	216392	0	3H-CLONIDINE	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	216393	0	3H-CLONIDINE	-1412	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	216394	0	3H-CLONIDINE	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-CLONIDINE	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216489	0	3H-CLONIDINE	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		11954224	215953	0	3H-CLONIDINE	-446	58	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1830	2590	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-CLONIDINE	-14	28	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		None	216032	0	3H-RAUWOLSCINE	-19	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	401	6	1	5	0.6	CS(=O)(=O)NCCN(C1CCN2CCC3=CC=CC=C3C2C1)S(=O)(=O)C	None
		11079	2733	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	2733	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	2733	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	2733	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	2733	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	2733	63	35S-GTPGammaS	1	5	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		179	400	115	125I-Clonidine	-35	49	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	125I-Clonidine	-35	49	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	125I-Clonidine	-35	49	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	125I-Clonidine	-35	49	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	125I-Clonidine	-35	49	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		1353	1911	93	3H-CLONIDINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-CLONIDINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-CLONIDINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-CLONIDINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-CLONIDINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		4209	3163	75	3H-RX821002	-1862	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	3H-RX821002	-1862	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	3H-RX821002	-1862	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	3H-RX821002	-1862	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	3H-RX821002	-1862	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	3H-RX821002	-1862	33	Pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		None	216341	0	3H-RX821002	-15	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		1267	3804	49	3H-RAUWOLSCINE	-52	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-RAUWOLSCINE	-52	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-RAUWOLSCINE	-52	26	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		None	216379	0	3H-RAUWOLSCINE	-141	11	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
		5268	3656	40	3H-RAUWOLSCINE	-63	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-RAUWOLSCINE	-63	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-RAUWOLSCINE	-63	18	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		68602	205126	80	35S-GTPGammaS	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	205126	80	35S-GTPGammaS	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		164512323	216031	0	3H-RAUWOLSCINE	-5	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RAUWOLSCINE	-5	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		122211	462	0	3H-RAUWOLSCINE	-239	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	462	0	3H-RAUWOLSCINE	-239	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		138107169	215952	0	3H-RAUWOLSCINE	-6	22	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-RAUWOLSCINE	-6	22	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		122211	462	0	3H-MK912	-239	6	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	462	0	3H-MK912	-239	6	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		10297	27112	30	3H-CLONIDINE	-5	42	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	27112	30	3H-CLONIDINE	-5	42	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		100	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		100	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-CLONIDINE	-33	55	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		44438148	93490	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	None
		CHEMBL246229	93490	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	430	6	0	6	5.1	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccn4)cc13)CC2	None
		135409468	2035	69	3H-CLONIDINE	-48	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-CLONIDINE	-48	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-CLONIDINE	-48	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		2995	204405	53	3H-RAUWOLSCINE	-12	23	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-RAUWOLSCINE	-12	23	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-RAUWOLSCINE	-12	23	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		None	215958	0	3H-MK912	-14	19	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		164512323	216031	0	3H-RX821002	-18	5	Pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RX821002	-18	5	Pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		44438166	93817	0	UNDEFINED	-33	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	None
		CHEMBL247664	93817	0	UNDEFINED	-33	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	467	8	2	7	3.5	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCC(C)(C)N)cc13)CC2	None
		25058166	215960	0	3H-RX821002	-70	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-RX821002	-70	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		484	2858	51	35S-GTPGammaS	-3	35	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	35S-GTPGammaS	-3	35	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	35S-GTPGammaS	-3	35	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		135398737	958	93	3H-CLONIDINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-RAUWOLSCINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-CLONIDINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-RAUWOLSCINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-CLONIDINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-RAUWOLSCINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-CLONIDINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-RAUWOLSCINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-CLONIDINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-RAUWOLSCINE	-26	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		7153	98020	77	3H-CLONIDINE	-7	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-CLONIDINE	-7	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		1028	291	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	35S-GTPGammaS	-48	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		3658	4107	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	4107	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	4107	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	4107	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	4107	53	35S-GTPGammaS	-5	8	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		124	2981	47	35S-GTPGammaS	-28	33	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	35S-GTPGammaS	-28	33	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	35S-GTPGammaS	-28	33	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	35S-GTPGammaS	-28	33	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	35S-GTPGammaS	-28	33	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		5524	216464	0	35S-GTPGammaS	-1	4	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	215	1	2	3	1.9	C1CCC2=C(C1)C=CC=C2NC3=NCCN3	None
		68602	205126	80	3H-MK912	-1	7	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	205126	80	3H-MK912	-1	7	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		1613	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2389	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1613	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-CLONIDINE	-8	44	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2389	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-CLONIDINE	-77	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		68712	100338	60	35S-GTPGammaS	-1	5	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		CHEMBL289480	100338	60	35S-GTPGammaS	-1	5	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		186	1807	52	3H-CLONIDINE	-263	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-CLONIDINE	-263	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-CLONIDINE	-263	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		16362	3125	71	3H-CLONIDINE	-501	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-CLONIDINE	-501	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-CLONIDINE	-501	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-CLONIDINE	-501	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-CLONIDINE	-501	30	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		11079	2733	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	2733	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	2733	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	2733	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	2733	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	2733	63	35S-GTPGammaS	1	5	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		2865	4143	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2865	4143	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-CLONIDINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-RAUWOLSCINE	-64	53	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3294	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		3294	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-RX821002	-47	45	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		119570	3159	96	3H-RX821002	-69	40	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-RX821002	-69	40	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-RX821002	-69	40	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-RX821002	-69	40	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-RX821002	-69	40	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		1223	953	41	3H-RAUWOLSCINE	-93	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		2790	953	41	3H-RAUWOLSCINE	-93	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		CHEMBL14690	953	41	3H-RAUWOLSCINE	-93	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	308	6	2	3	3.2	Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N	None
		134	2514	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-CLONIDINE	-74	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		122211	462	0	3H-RAUWOLSCINE	-239	6	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	462	0	3H-RAUWOLSCINE	-239	6	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		16725934	147423	0	UNDEFINED	-87	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	None
		CHEMBL392992	147423	0	UNDEFINED	-87	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	429	6	0	5	5.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2	None
		15897	2862	0	3H-CLONIDINE	-134	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-CLONIDINE	-134	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-CLONIDINE	-134	36	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		103	4153	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-RAUWOLSCINE	-54	53	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-CLONIDINE	-87	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1220	187	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-RAUWOLSCINE	-147	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		44438168	93818	0	UNDEFINED	-53	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	None
		CHEMBL247665	93818	0	UNDEFINED	-53	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	533	7	0	7	4.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2	None
		2402	3370	62	3H-RX821002	-6	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	3H-RX821002	-6	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	3H-RX821002	-6	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	3H-RX821002	-6	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	3H-RX821002	-6	24	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		2142	3096	58	3H-RX821002	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RX821002	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RX821002	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RX821002	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RX821002	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RX821002	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		185	4006	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-CLONIDINE	-5888	37	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		135398745	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		484	2858	51	35S-GTPGammaS	-2	35	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	35S-GTPGammaS	-2	35	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	35S-GTPGammaS	-2	35	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		68602	205126	80	35S-GTPGammaS	-1	7	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	205126	80	35S-GTPGammaS	-1	7	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		None	215959	0	3H-RAUWOLSCINE	-2	6	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	358	4	0	3	2.8	CCCS(=O)(=O)N(C)C1CCN2CCC3=CC=CC=C3C2C1.Cl	None
		123981	16459	22	3H-RAUWOLSCINE	-2	8	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	None
		CHEMBL123349	16459	22	3H-RAUWOLSCINE	-2	8	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	None
		CHEMBL536803	16459	22	3H-RAUWOLSCINE	-2	8	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	195	0	0	1	2.4	CN1CCc2cccc(Cl)c2CC1	None
		2142	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	3096	58	3H-RX821002	-1	36	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RX821002	-1	36	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RX821002	-1	36	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RX821002	-1	36	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RX821002	-1	36	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RX821002	-1	36	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		1816	2540	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-RAUWOLSCINE	-51	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		1343	1889	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	1889	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	1889	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	1889	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	1889	62	35S-GTPGammaS	-3	9	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		2142	3096	58	35S-GTPGammaS	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	35S-GTPGammaS	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	35S-GTPGammaS	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	35S-GTPGammaS	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	35S-GTPGammaS	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	35S-GTPGammaS	-2	36	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		11079	2733	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	2733	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	2733	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	2733	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	2733	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	2733	63	35S-GTPGammaS	-1	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		25137849	216179	0	3H-CLONIDINE	-2	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-CLONIDINE	-2	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		11750482	147421	0	UNDEFINED	-25	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	None
		CHEMBL392991	147421	0	UNDEFINED	-25	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	419	6	0	6	5.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccco4)cc13)CC2	None
		3952	1888	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	1888	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	1888	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	1888	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	1888	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	1888	38	35S-GTPGammaS	-3	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		2435	722	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		395	722	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		520	722	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5386	722	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		CHEMBL844	722	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		DB00484	722	100	35S-GTPGammaS	-2	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		4209	3163	75	3H-RAUWOLSCINE	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	3H-RAUWOLSCINE	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	3H-RAUWOLSCINE	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	3H-RAUWOLSCINE	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	3H-RAUWOLSCINE	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	3H-RAUWOLSCINE	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		44438161	147141	0	UNDEFINED	-22	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	None
		CHEMBL392771	147141	0	UNDEFINED	-22	3	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	543	10	1	7	5.0	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4cccc(C(=O)NCCN(C)C)c4)cc13)CC2	None
		2337	3256	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-RAUWOLSCINE	-50	62	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		4209	3163	75	3H-MK912	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	3H-MK912	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	3H-MK912	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	3H-MK912	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	3H-MK912	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	3H-MK912	-3235	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		2695	3841	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		5504	3841	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		7310	3841	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		CHEMBL770	3841	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		DB00797	3841	81	35S-GTPGammaS	-9	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		2389	3331	118	3H-RAUWOLSCINE	-77	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-RAUWOLSCINE	-77	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-RAUWOLSCINE	-77	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-RAUWOLSCINE	-77	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-RAUWOLSCINE	-77	67	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3658	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		103	4153	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-CLONIDINE	-54	53	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		523	4106	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		5707	4106	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		CHEMBL297362	4106	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		DB11477	4106	93	35S-GTPGammaS	1	5	Mouse	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		135398737	958	93	3H-RAUWOLSCINE	-26	89	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-RAUWOLSCINE	-26	89	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-RAUWOLSCINE	-26	89	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-RAUWOLSCINE	-26	89	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-RAUWOLSCINE	-26	89	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2695	3841	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		5504	3841	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		7310	3841	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		CHEMBL770	3841	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		DB00797	3841	81	3H-RAUWOLSCINE	-9	6	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		2803	955	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	3H-RX821002	1	19	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		124	2981	47	35S-GTPGammaS	-28	33	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	35S-GTPGammaS	-28	33	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	35S-GTPGammaS	-28	33	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	35S-GTPGammaS	-28	33	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	35S-GTPGammaS	-28	33	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		3658	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	4107	53	35S-GTPGammaS	-9	8	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		2726	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1615	167791	24	3H-CLONIDINE	-6	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-CLONIDINE	-6	44	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		2726	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-RAUWOLSCINE	-87	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		44438152	93608	0	UNDEFINED	-134	3	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	None
		CHEMBL246639	93608	0	UNDEFINED	-134	3	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	459	7	0	6	5.7	COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1	None
		162265	202274	22	3H-CLONIDINE	-12	43	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-CLONIDINE	-12	43	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-CLONIDINE	-12	43	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		162265	202274	22	3H-CLONIDINE	-12	43	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-CLONIDINE	-12	43	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-CLONIDINE	-12	43	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5268	3656	40	3H-RAUWOLSCINE	-63	18	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-RAUWOLSCINE	-63	18	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-RAUWOLSCINE	-63	18	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		None	216239	0	3H-CLONIDINE	-30199	30	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		2216	446	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		229	446	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		7117	446	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		CHEMBL647	446	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		DB00964	446	50	3H-Yohimbine	-57	6	Pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		102	4127	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-RX821002	-5	49	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		68602	205126	80	3H-RX821002	-1	7	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	205126	80	3H-RX821002	-1	7	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		124	2981	47	3H-RX821002	-16	33	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-RX821002	-16	33	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-RX821002	-16	33	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-RX821002	-16	33	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-RX821002	-16	33	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		5268	3656	40	3H-RX821002	-10	18	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-RX821002	-10	18	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-RX821002	-10	18	Pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		68602	205126	80	35S-GTPGammaS	1	7	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		CHEMBL77921	205126	80	35S-GTPGammaS	1	7	Mouse	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	None
		138107169	215952	0	3H-RAUWOLSCINE	-6	22	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-RAUWOLSCINE	-6	22	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		None	215958	0	3H-RAUWOLSCINE	-14	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	421	9	1	6	4.3	COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4	None
		102	4127	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-MK912	-5	49	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		138107169	215952	0	3H-MK912	-6	22	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	3H-MK912	-6	22	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		115237	55585	119	3H-RAUWOLSCINE	-44	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-RAUWOLSCINE	-44	54	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		122295	9868	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		CHEMBL114166	9868	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		4209	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		162265	202274	22	3H-CLONIDINE	-12	43	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-CLONIDINE	-12	43	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-CLONIDINE	-12	43	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		1212	1662	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-RAUWOLSCINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		11225732	93657	0	UNDEFINED	-16	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	None
		CHEMBL246852	93657	0	UNDEFINED	-16	3	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	497	6	0	5	6.7	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2	None
		2803	955	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	3H-RX821002	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		5524	216464	0	35S-GTPGammaS	1	4	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	215	1	2	3	1.9	C1CCC2=C(C1)C=CC=C2NC3=NCCN3	None
		1212	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		135398745	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1212	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-CLONIDINE	-165	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		135398745	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-CLONIDINE	-93	65	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		4209	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	3H-RAUWOLSCINE	-3235	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		133621	2012	0	35S-GTPGammaS	-6	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	3	0	4	2.3	CCn1ccnc1CC1COc2c(O1)cccc2	None
		3470	2012	0	35S-GTPGammaS	-6	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	3	0	4	2.3	CCn1ccnc1CC1COc2c(O1)cccc2	None
		CHEMBL347695	2012	0	35S-GTPGammaS	-6	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	244	3	0	4	2.3	CCn1ccnc1CC1COc2c(O1)cccc2	None
		523	4106	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		5707	4106	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		CHEMBL297362	4106	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		DB11477	4106	93	3H-Yohimbine	-1	5	Pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		122295	9868	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		CHEMBL114166	9868	7	3H-RAUWOLSCINE	-1	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		None	216239	0	3H-CLONIDINE	-30199	30	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		122295	9868	7	3H-RX821002	-1	9	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		CHEMBL114166	9868	7	3H-RX821002	-1	9	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	3.7	CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2	None
		2803	955	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	35S-GTPGammaS	-1	19	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		124	2981	47	3H-Yohimbine	-16	33	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-Yohimbine	-16	33	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-Yohimbine	-16	33	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-Yohimbine	-16	33	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-Yohimbine	-16	33	Pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		138107169	215952	0	35S-GTPGammaS	-97	22	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		22831402	215952	0	35S-GTPGammaS	-97	22	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
		2337	3256	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	125I-Clonidine	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-CLONIDINE	-50	62	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		122211	462	0	3H-RX821002	-229	6	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	462	0	3H-RX821002	-229	6	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		104870	98880	47	3H-RX821002	-2	21	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	3H-RX821002	-2	21	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	3H-RX821002	-2	21	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		484	2858	51	3H-RX821002	-3	35	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-RX821002	-3	35	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-RX821002	-3	35	Pig	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		1524	2181	96	3H-RAUWOLSCINE	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-RAUWOLSCINE	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-RAUWOLSCINE	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-RAUWOLSCINE	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-RAUWOLSCINE	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-RAUWOLSCINE	-281	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		122211	462	0	3H-RAUWOLSCINE	-239	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		524	462	0	3H-RAUWOLSCINE	-239	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	None
		3337	206367	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-CLONIDINE	-27	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		67409	216034	0	3H-RAUWOLSCINE	-7	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	235	2	0	1	3.9	C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1	None
		8966	216034	0	3H-RAUWOLSCINE	-7	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	235	2	0	1	3.9	C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1	None
		1028	291	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	35S-GTPGammaS	-72	30	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		484	2858	51	35S-GTPGammaS	-2	35	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	35S-GTPGammaS	-2	35	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	35S-GTPGammaS	-2	35	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		104870	98880	47	35S-GTPGammaS	-2	21	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	35S-GTPGammaS	-2	21	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	35S-GTPGammaS	-2	21	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		24840389	115213	4	3H-RX821002	-295	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		CHEMBL334529	115213	4	3H-RX821002	-295	16	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		2142	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		931	216463	0	35S-GTPGammaS	-1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	128	0	0	0	2.8	C1=CC=C2C=CC=CC2=C1	None
		115237	55585	119	3H-CLONIDINE	-44	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-CLONIDINE	-44	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		135	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		12057539	208041	42	None	-9	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	None	-9	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	None	-9	20	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		124	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-RAUWOLSCINE	-4	33	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2803	955	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	35S-GTPGammaS	-3	19	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		44438147	93489	0	UNDEFINED	-20	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	None
		CHEMBL246228	93489	0	UNDEFINED	-20	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	406	5	1	9	2.5	COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2	None
		10836	14467	14	3H-CLONIDINE	-2	9	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	14467	14	3H-CLONIDINE	-2	9	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		44438167	148970	0	UNDEFINED	-52	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	None
		CHEMBL394218	148970	0	UNDEFINED	-52	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	505	7	1	7	3.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2	None
		2435	722	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		395	722	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		520	722	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5386	722	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		CHEMBL844	722	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		DB00484	722	100	35S-GTPGammaS	-7	12	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		100	3805	58	3H-RAUWOLSCINE	-33	55	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-RAUWOLSCINE	-33	55	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-RAUWOLSCINE	-33	55	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-RAUWOLSCINE	-33	55	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-RAUWOLSCINE	-33	55	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		44438165	166784	0	UNDEFINED	-48	3	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	None
		CHEMBL428407	166784	0	UNDEFINED	-48	3	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	467	9	1	7	3.3	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NCCN(C)C)cc13)CC2	None
		135	2532	43	3H-RAUWOLSCINE	-4	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-RAUWOLSCINE	-4	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-RAUWOLSCINE	-4	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-RAUWOLSCINE	-4	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-RAUWOLSCINE	-4	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		164512323	216031	0	3H-RAUWOLSCINE	-5	5	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RAUWOLSCINE	-5	5	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		135398745	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-RAUWOLSCINE	-93	65	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1353	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-RAUWOLSCINE	-190	83	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2435	722	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		395	722	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		520	722	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5386	722	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		CHEMBL844	722	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		DB00484	722	100	3H-Yohimbine	-81	12	Pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	None
		5280805	85405	81	None	-28	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	Drug Central	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	None
		CHEMBL226335	85405	81	None	-28	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity to adrenergic alpha2A receptorBinding affinity to adrenergic alpha2A receptor	Drug Central	610	6	10	16	-1.7	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O	None
		1210	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-416	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		3823	50221	42	None	-40	10	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		76973198	50221	42	None	-40	10	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL157101	50221	42	None	-40	10	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		28417	40039	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		CHEMBL1479	40039	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		3652	46244	70	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		CHEMBL1535	46244	70	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		135	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-RAUWOLSCINE	-4	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1960	2857	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		439260	2857	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		505	2857	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL1437	2857	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00368	2857	67	None	-35	26	Mouse	8.3	pKi	=	8.3	Binding	Binding affinity to mouse alpha-2A receptor expressed in COS7 cellsBinding affinity to mouse alpha-2A receptor expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		4158	205341	21	None	-2	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	205341	21	None	-2	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	205341	21	None	-2	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		448537	160250	89	None	-33	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		CHEMBL411	160250	89	None	-33	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		2812	4779	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	4779	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		2719	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		5535	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		607	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		CHEMBL76	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		DB00608	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		10836	14467	14	None	-2	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	14467	14	None	-2	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		4209	3163	75	None	-1862	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	None	-1862	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	None	-1862	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	None	-1862	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	None	-1862	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	None	-1862	33	Pig	8.3	pKi	=	8.3	Binding	Compound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]-RX 821002 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		6040	216033	0	3H-RAUWOLSCINE	-4	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	233	2	0	3	2.3	C1CCN(CC1)CC2COC3=CC=CC=C3O2	None
		2337	3256	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	None	-50	62	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5268	3656	40	3H-RAUWOLSCINE	-63	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-RAUWOLSCINE	-63	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-RAUWOLSCINE	-63	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		4211	57822	83	None	-1	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
		CHEMBL1670	57822	83	None	-1	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
		1443	2028	34	None	-23	10	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		33625	2028	34	None	-23	10	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		501	2028	34	None	-23	10	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		CHEMBL279516	2028	34	None	-23	10	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		DB08950	2028	34	None	-23	10	Human	8.3	pKi	=	8.3	Binding	The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones.	Drug Central	347	5	2	2	3.6	O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2	None
		1549008	205680	85	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	None
		CHEMBL822	205680	85	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	291	4	0	1	4.9	CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12	None
		121850	726	0	3H-MK912	41	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	None
		525	726	0	3H-MK912	41	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	None
		CHEMBL216097	726	0	3H-MK912	41	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	None
		3598	187821	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		CHEMBL496	187821	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		2402	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	None	-6	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		2247	505	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	None	-58	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		5198	19433	54	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	None
		CHEMBL12948	19433	54	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	247	4	1	3	2.5	CC1CCC(NC(=O)N(CCCl)N=O)CC1	None
		3117	207841	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		CHEMBL964	207841	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		4209	3163	75	None	-616	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	None	-616	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	None	-616	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	None	-616	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	None	-616	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	None	-616	33	Rat	8.2	pKi	=	8.2	Binding	The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones.	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		3198	205513	76	None	-19	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	205513	76	None	-19	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	205513	76	None	-19	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		16362	3125	71	None	-501	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	None	-501	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	None	-501	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	None	-501	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	None	-501	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		5318	15576	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1200348	15576	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1221	15576	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		5353853	17986	47	None	-16	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		9556529	17986	47	None	-16	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1262	17986	47	None	-16	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1836	2592	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		3340	2592	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		5281040	2592	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		CHEMBL787	2592	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		DB00471	2592	59	None	-43	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		4189	206922	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	206922	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	206922	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		2406	100404	89	None	-16	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		CHEMBL290106	100404	89	None	-16	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		119584	2595	102	None	-2	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		1848	2595	102	None	-2	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		242	2595	102	None	-2	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		CHEMBL60889	2595	102	None	-2	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		DB11675	2595	102	None	-2	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
		2484	208293	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	None
		CHEMBL990	208293	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	317	4	0	1	5.8	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12	None
		2342	599	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		331	599	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		7124	599	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		CHEMBL1201250	599	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		DB00767	599	39	None	-1	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	None
		2335	11848	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		8478	11848	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL1182210	11848	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL221753	11848	22	None	-5	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		1227	2489	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		2331	2489	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3957	2489	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		4992	2489	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		CHEMBL511	2489	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		DB06691	2489	43	None	-91	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
		3168	9262	92	None	-123	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	9262	92	None	-123	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		1353	1911	93	None	-190	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-190	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-190	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-190	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-190	83	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1830	2590	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	None	-14	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		3151	1462	97	None	-99	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	1462	97	None	-99	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	1462	97	None	-99	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	1462	97	None	-99	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	1462	97	None	-99	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		1782	2518	84	None	-5	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	2518	84	None	-5	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	2518	84	None	-5	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	2518	84	None	-5	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	2518	84	None	-5	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		135398737	958	93	3H-RAUWOLSCINE	-26	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-RAUWOLSCINE	-26	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-RAUWOLSCINE	-26	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-RAUWOLSCINE	-26	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-RAUWOLSCINE	-26	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2803	955	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	3H-MK912	-1	19	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		2105	3054	37	3H-RX821002	-58	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-RX821002	-58	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-RX821002	-58	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-RX821002	-58	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-RX821002	-58	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		1343	1889	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	1889	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	1889	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	1889	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	1889	62	3H-MK912	-11	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		15897	2862	0	3H-CLONIDINE	-134	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-CLONIDINE	-134	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-CLONIDINE	-134	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		11957583	216194	0	3H-Yohimbine	-	1	Pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	391	1	2	3	3.4	C1CN=C(N1)NC2=C(C=C(C=C2Cl)I)Cl.Cl	None
		2398	954	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	3H-RX821002	-14	29	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		6852400	215937	0	3H-RAUWOLSCINE	-131	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-RAUWOLSCINE	-131	22	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		3337	206367	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-CLONIDINE	-27	40	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		5268	3656	40	3H-MK912	-63	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-MK912	-63	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-MK912	-63	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		2726	919	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-RAUWOLSCINE	-87	72	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		4158	205341	21	125I-Clonidine	-2	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	205341	21	125I-Clonidine	-2	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	205341	21	125I-Clonidine	-2	21	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		484	2858	51	3H-Yohimbine	-3	35	Pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-Yohimbine	-3	35	Pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-Yohimbine	-3	35	Pig	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		3952	1888	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	1888	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	1888	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	1888	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	1888	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	1888	38	3H-Yohimbine	-9	12	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		1222	1664	49	3H-RAUWOLSCINE	-100	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	3H-RAUWOLSCINE	-100	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	3H-RAUWOLSCINE	-100	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	3H-RAUWOLSCINE	-100	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	3H-RAUWOLSCINE	-100	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		523	4106	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		5707	4106	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		CHEMBL297362	4106	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		DB11477	4106	93	35S-GTPGammaS	-2	5	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	None
		2142	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-RAUWOLSCINE	-2	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		6018	11065	96	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	None
		CHEMBL117785	11065	96	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	None
		463	1405	22	None	-67	12	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		6918097	1405	22	None	-67	12	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		837	1405	22	None	-67	12	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		CHEMBL2051956	1405	22	None	-67	12	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		DB14068	1405	22	None	-67	12	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	None
		237	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL546257	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL554190	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL7568	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		2181	3128	46	None	-58	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	None	-58	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	None	-58	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	None	-58	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	None	-58	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		1530	2182	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	-70	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		4601	206747	35	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		5467	205928	43	None	-6	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	None
		CHEMBL84158	205928	43	None	-6	5	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	None
		1577	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	None	-3	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		657255	199084	34	None	-10	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		CHEMBL588119	199084	34	None	-10	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		3157	1470	71	None	-61	10	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		7170	1470	71	None	-61	10	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		954	1470	71	None	-61	10	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		CHEMBL707	1470	71	None	-61	10	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		DB00590	1470	71	None	-61	10	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Alpha-2A adrenergic receptor, from human clones.Binding affinity against Alpha-2A adrenergic receptor, from human clones.	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
		1016	3747	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	3747	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	3747	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	3747	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	3747	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	3747	78	None	-12	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		4011	82408	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		26757	207978	31	None	-1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	None
		CHEMBL972	207978	31	None	-1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	None
		219050	3373	25	3H-RX821002	-38	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	3373	25	3H-RX821002	-38	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	3373	25	3H-RX821002	-38	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		240	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	None	-12	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		214	3860	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	None	-75	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		209	3057	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	None	-100	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2435	3590	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	None	-123	48	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1042	1581	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	1581	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	1581	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	1581	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	1581	23	None	-97	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		2726	919	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-87	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		134	2514	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-74	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2351	3286	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	3286	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	3286	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	3286	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	3286	64	None	-9	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		150	2509	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		1764	2509	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		8226	2509	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		CHEMBL1201356	2509	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		DB00353	2509	21	None	-45	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		6726	1280	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	1280	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	1280	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	1280	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	1280	51	None	-10	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		1222	1664	49	None	-100	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	None	-100	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	None	-100	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	None	-100	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	None	-100	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		6075	150108	42	None	-11	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		CHEMBL395110	150108	42	None	-11	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		3584	3777	64	None	-251	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		5401	3777	64	None	-251	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		7302	3777	64	None	-251	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		CHEMBL611	3777	64	None	-251	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		DB01162	3777	64	None	-251	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	None
		2398	954	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	None	-14	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		66265	94013	15	None	-1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	94013	15	None	-1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		4735	195115	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL361506	195115	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL55	195115	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		1225	1471	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	None	-22	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		2865	4143	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-64	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		41	1659	0	3H-RX821002	-5	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	1659	0	3H-RX821002	-5	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	1659	0	3H-RX821002	-5	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		2142	3096	58	3H-PRAZOSIN	-2	36	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-PRAZOSIN	-2	36	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-PRAZOSIN	-2	36	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-PRAZOSIN	-2	36	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-PRAZOSIN	-2	36	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-PRAZOSIN	-2	36	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		102	4127	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-RX821002	-5	49	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		191	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-41	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		3561	19077	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		CHEMBL1289	19077	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		4098	32505	30	None	-13	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	32505	30	None	-13	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	32505	30	None	-13	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		164512323	216031	0	3H-RAUWOLSCINE	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RAUWOLSCINE	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		441383	20333	57	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL1306	20333	57	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		1548955	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		135398745	2914	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-93	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1212	1662	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-165	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3389	217711	0	None	-1	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		46780481	107531	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-RAUWOLSCINE	-47	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		3191	102858	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	102858	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		1028	291	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	None	-48	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		1971	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		162265	202274	22	None	-12	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	None	-12	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	None	-12	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		213	3853	55	None	-10	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	None	-10	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	None	-10	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	None	-10	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	None	-10	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2286	3183	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	None	-13	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2695	3841	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		5504	3841	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		7310	3841	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		CHEMBL770	3841	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		DB00797	3841	81	None	-9	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	None
		2162	41514	100	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	None
		CHEMBL1491	41514	100	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	None
		12488	1657	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		941361	1657	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		CHEMBL30008	1657	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		DB04841	1657	56	None	-6	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		2520	204008	70	None	-6	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		CHEMBL1280	204008	70	None	-6	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		CHEMBL6966	204008	70	None	-6	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
		4209	3163	75	None	-3235	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	None	-3235	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	None	-3235	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	None	-3235	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	None	-3235	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	None	-3235	33	Human	8.2	pKi	=	8.2	Binding	Ability to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2A adrenergic receptor	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		1201549	597	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	597	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	597	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	597	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	597	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	597	24	None	-33	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		103	4153	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-54	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		11057	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		1547484	940	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		654	940	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		9072	940	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL43064	940	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB00568	940	74	None	-5	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		3294	2006	111	None	-47	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-47	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-47	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-47	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-47	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		12574	2605	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		4810	2605	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		CHEMBL19236	2605	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		DB09242	2605	88	None	-33	6	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	None
		1613	2348	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-8	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		15387	45822	55	None	-1	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	None	-1	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		5472	205818	75	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	None
		CHEMBL1717	205818	75	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	None
		CHEMBL833	205818	75	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	None
		100	3805	58	None	-33	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-33	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-33	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-33	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-33	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		180	401	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-58	40	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2284	3182	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	None	-12	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		228	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	445	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		104870	98880	47	None	-2	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	None	-2	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	None	-2	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		68617	205527	62	None	-3	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	None	-3	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	None	-3	26	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		4209	3163	75	None	-173	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	None	-173	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	None	-173	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	None	-173	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	None	-173	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	None	-173	33	Bovine	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		277	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		15897	2862	0	3H-CLONIDINE	-134	36	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-CLONIDINE	-134	36	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-CLONIDINE	-134	36	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		2803	955	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		2803	955	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	35S-GTPGammaS	-1	19	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	35S-GTPGammaS	-3	19	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		102	4127	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	35S-GTPGammaS	-154	49	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2683	3834	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		5487	3834	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		7308	3834	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		CHEMBL1079	3834	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		DB00697	3834	60	3H-RAUWOLSCINE	-3	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	None
		102	4127	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-PRAZOSIN	-158	49	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2726	919	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-RX821002	-38	72	Pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2435	3590	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		2435	3590	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-CLONIDINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-RAUWOLSCINE	-123	48	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1028	291	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	3H-Yohimbine	-120	30	Pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		214	3860	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-CLONIDINE	-75	30	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		None	216325	0	3H-CLONIDINE	-8	40	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		2202	3132	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	3132	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	3132	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	3132	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	3132	96	None	-1	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		212	3806	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	3806	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	3806	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	3806	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	3806	47	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		242	470	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-26	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		135398737	958	93	None	-26	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-26	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-26	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-26	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-26	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		26987	949	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	949	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	949	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	949	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	949	33	None	-158	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		1960	2857	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		439260	2857	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		505	2857	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL1437	2857	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00368	2857	67	None	-23	26	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Alpha-2A adrenergic receptorBinding affinity for human Alpha-2A adrenergic receptor	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		2274	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	None	-10	31	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		124	2981	47	35S-GTPGammaS	-4	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	35S-GTPGammaS	-4	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	35S-GTPGammaS	-4	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	35S-GTPGammaS	-4	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	35S-GTPGammaS	-4	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2105	3054	37	None	-58	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	None	-58	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	None	-58	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	None	-58	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	None	-58	33	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		117590588	96524	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	None
		14969	96524	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	None
		CHEMBL262777	96524	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	1447	13	19	25	0.1	CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O	None
		102	4127	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	None	-47	49	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		213046	2385	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		4168	2385	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		7461	2385	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		CHEMBL1237021	2385	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		DB08815	2385	59	None	-19	9	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
		2585	803	103	None	-28	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		522	803	103	None	-28	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		551	803	103	None	-28	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		CHEMBL723	803	103	None	-28	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		DB01136	803	103	None	-28	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		68712	100338	60	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	Drug Central	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		CHEMBL289480	100338	60	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter	Drug Central	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		5524	216464	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	215	1	2	3	1.9	C1CCC2=C(C1)C=CC=C2NC3=NCCN3	None
		240	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	None	-3	24	Rat	8.1	pKi	=	8.1	Binding	Compound was evaluated for the binding affinity at Alpha adrenergic receptorCompound was evaluated for the binding affinity at Alpha adrenergic receptor	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2389	3331	118	None	-37	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-37	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-37	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-37	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-37	67	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6761	67799	19	None	-6	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL1909072	67799	19	None	-6	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		133	2496	52	None	-23	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-23	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-23	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-23	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-23	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		124	2981	47	None	-16	33	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	None	-16	33	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	None	-16	33	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	None	-16	33	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	None	-16	33	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		11079	2733	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		3369	2733	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		4436	2733	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		5509	2733	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		CHEMBL761	2733	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		DB06711	2733	63	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	None
		1816	2540	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	None	-51	18	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		135398737	958	93	None	-10	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-10	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-10	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-10	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-10	89	Rat	8.1	pKi	=	8.1	Binding	Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]clonidine binding to rat cortex using unlabeled NAbitartrate for nonspecific binding.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		931	216463	0	35S-GTPGammaS	-2	4	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	128	0	0	0	2.8	C1=CC=C2C=CC=CC2=C1	None
		135	2532	43	None	-5	58	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-5	58	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-5	58	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-5	58	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-5	58	Bovine	8.1	pKi	=	8.1	Binding	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		3952	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5353646	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5443	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		5702063	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL1331786	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		CHEMBL420	1888	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
		11978813	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	721	79	None	-9	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		3658	4107	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		517	4107	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		5709	4107	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		CHEMBL312448	4107	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		DB06694	4107	53	None	-5	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	None
		10219	188796	37	None	-1	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	None
		CHEMBL493439	188796	37	None	-1	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	None
		CHEMBL50588	188796	37	None	-1	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	None
		129211	3749	78	None	-120	15	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		2562	3749	78	None	-120	15	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		488	3749	78	None	-120	15	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		CHEMBL836	3749	78	None	-120	15	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		DB00706	3749	78	None	-120	15	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human adrenergic receptor subtype Alpha-2A adrenergic receptor using [3H]rauwolscine as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
		37	778	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		460	778	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		54746	778	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		CHEMBL1201087	778	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		DB00248	778	60	None	-3	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		115237	55585	119	None	-44	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	None	-44	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		2216	446	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		229	446	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		7117	446	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		CHEMBL647	446	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		DB00964	446	50	35S-GTPGammaS	1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		41	1659	0	3H-MK912	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		41	1659	0	3H-RX821002	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	1659	0	3H-MK912	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		72036	1659	0	3H-RX821002	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	1659	0	3H-MK912	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		CHEMBL1765294	1659	0	3H-RX821002	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	195	0	1	3	0.9	Fc1cccc2c1O[C@H]1CNC[C@@H]1O2	None
		102	4127	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-MK912	-5	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		None	216329	0	3H-CLONIDINE	2	28	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		68712	100338	60	35S-GTPGammaS	-9	5	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		CHEMBL289480	100338	60	35S-GTPGammaS	-9	5	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	None
		None	216135	0	3H-CLONIDINE	-758	24	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		213	3853	55	125I-Clonidine	-10	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	125I-Clonidine	-10	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	125I-Clonidine	-10	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	125I-Clonidine	-10	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	125I-Clonidine	-10	44	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		242	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-CLONIDINE	-26	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		119570	3159	96	3H-CLONIDINE	-69	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-CLONIDINE	-69	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-CLONIDINE	-69	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-CLONIDINE	-69	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-CLONIDINE	-69	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2726	919	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-RAUWOLSCINE	-87	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		135398737	958	93	3H-RAUWOLSCINE	-26	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-RAUWOLSCINE	-26	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-RAUWOLSCINE	-26	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-RAUWOLSCINE	-26	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-RAUWOLSCINE	-26	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11954259	215979	0	3H-CLONIDINE	-263	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		4209	3163	75	35S-GTPGammaS	-3235	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		4893	3163	75	35S-GTPGammaS	-3235	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		503	3163	75	35S-GTPGammaS	-3235	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		5385	3163	75	35S-GTPGammaS	-3235	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		CHEMBL2	3163	75	35S-GTPGammaS	-3235	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		DB00457	3163	75	35S-GTPGammaS	-3235	33	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
		31101	729	40	None	-10	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	None	-10	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	None	-10	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	None	-10	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	None	-10	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		2389	3331	118	None	-77	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-77	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-77	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-77	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-77	67	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		12575	1988	30	UNDEFINED	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	1988	30	UNDEFINED	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	1988	30	UNDEFINED	-5	17	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1209	1658	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	None	-1	32	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		5268	3656	40	3H-RAUWOLSCINE	-63	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		53	3656	40	3H-RAUWOLSCINE	-63	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		CHEMBL300555	3656	40	3H-RAUWOLSCINE	-63	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
		135	2532	43	None	-4	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-4	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-4	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-4	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-4	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2142	3096	58	None	-2	36	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	None	-2	36	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	None	-2	36	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	None	-2	36	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	None	-2	36	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	None	-2	36	Rat	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.The compound was tested for binding affinity against alpha-2D adrenergic receptor, from rat clones.	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		102	4127	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	None	-15	49	Pig	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-cloneCompound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		1593	2340	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		30668	2340	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		9868	2340	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		CHEMBL17860	2340	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		DB04948	2340	66	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2A expressed in CHO cells	Drug Central	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	None
		2803	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	None	-1	19	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		134551	358	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	358	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	358	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	358	27	None	-3	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		2216	446	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		229	446	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		7117	446	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		CHEMBL647	446	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		DB00964	446	50	None	1	6	Human	8.1	pKi	=	8.1	Binding	Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells	Drug Central	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	None
		None	216035	0	3H-RAUWOLSCINE	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	200	3	1	1	2.8	CC1=C(C(=CC=C1)C)CCC2=CN=CN2	None
		2142	3096	58	None	-2	36	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	None	-2	36	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	None	-2	36	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	None	-2	36	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	None	-2	36	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	None	-2	36	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]RX781094 from alpha2 adrenergic receptorDisplacement of [3H]RX781094 from alpha2 adrenergic receptor	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		124	2981	47	None	-5	33	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	None	-5	33	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	None	-5	33	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	None	-5	33	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	None	-5	33	Bovine	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pinealCompound was evaluated for inhibition of binding of [3H]MK-91 to Alpha-2 adrenergic receptor in bovine pineal	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		164512323	216031	0	3H-RAUWOLSCINE	-5	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		6419959	216031	0	3H-RAUWOLSCINE	-5	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	352	1	1	4	3.2	CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45	None
		11954259	215979	0	3H-CLONIDINE	-263	43	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		3337	206367	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-CLONIDINE	-27	40	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		209	3057	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-CLONIDINE	-100	23	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2803	955	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	3H-Yohimbine	-5	19	Pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		11293787	148213	0	UNDEFINED	-77	3	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	None
		CHEMBL393597	148213	0	UNDEFINED	-77	3	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	447	6	0	5	5.8	COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2	None
		2181	3128	46	3H-RAUWOLSCINE	-58	35	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-RAUWOLSCINE	-58	35	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-RAUWOLSCINE	-58	35	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-RAUWOLSCINE	-58	35	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-RAUWOLSCINE	-58	35	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		2202	3132	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	3132	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	3132	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	3132	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	3132	96	3H-RX821002	-1	21	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		None	216330	0	UNDEFINED	-8	28	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		2142	3096	58	None	1	36	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	None	1	36	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	None	1	36	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	None	1	36	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	None	1	36	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	None	1	36	Bovine	8.0	pKi	=	8.0	Binding	Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandBinding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		11954224	215953	0	None	-446	58	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		107715	200945	22	None	-6	19	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL1255837	200945	22	None	-6	19	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL601773	200945	22	None	-6	19	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		931	216463	0	35S-GTPGammaS	-2	4	Mouse	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	128	0	0	0	2.8	C1=CC=C2C=CC=CC2=C1	None
		102	4127	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	None	-5	49	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		2803	955	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		516	955	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		704	955	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		CHEMBL134	955	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		DB00575	955	58	None	1	19	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards alpha-2D adrenergic receptorBinding affinity towards alpha-2D adrenergic receptor	Drug Central	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	None
		10531	1420	21	None	-5	23	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	1420	21	None	-5	23	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	1420	21	None	-5	23	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	1420	21	None	-5	23	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	1420	21	None	-5	23	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		2601	3780	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	None	-1	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		124	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2A receptor (unknown origin)	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		124	2981	47	3H-MK912	-4	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		2032	2981	47	3H-MK912	-4	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		4636	2981	47	3H-MK912	-4	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		CHEMBL762	2981	47	3H-MK912	-4	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		DB00935	2981	47	3H-MK912	-4	33	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
		12575	1988	30	35S-GTPGammaS	-5	17	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	1988	30	35S-GTPGammaS	-5	17	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	1988	30	35S-GTPGammaS	-5	17	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1588	2325	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	None	1	44	Human	8.0	pKi	=	8	Binding	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1576	216326	0	3H-CLONIDINE	-15	40	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		1343	1889	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		3519	1889	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		522	1889	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		CHEMBL862	1889	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		DB01018	1889	62	35S-GTPGammaS	-11	9	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
		None	216330	0	3H-CLONIDINE	-8	28	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		21830793	91835	10	3H-8-OH-DPAT	-630	45	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	91835	10	3H-8-OH-DPAT	-630	45	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		None	216036	0	3H-RAUWOLSCINE	-16	3	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	334	4	1	4	4.6	CN(C)CCCN1C2=C(C=C(C=C2)O)SC3=C1C=C(C=C3)Cl	None
		484	2858	51	3H-RAUWOLSCINE	-2	35	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-RAUWOLSCINE	-2	35	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-RAUWOLSCINE	-2	35	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		1593	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		30668	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		9868	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		CHEMBL17860	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		DB04948	2340	66	None	5	4	Human	8.4	pKi	=	8.4	Binding	Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α<sub>2A</sub>-AR.	Guide to Pharmacology	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	22341244
		1816	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		1816	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		4205	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		4205	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		7241	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		7241	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		CHEMBL654	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		CHEMBL654	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		DB00370	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	15771415
		DB00370	2540	102	None	-51	18	Human	7.0	pKi	=	7.0	Binding	Inhibition of [<sup>3</sup>H]rauwolscine binding.Inhibition of [<sup>3</sup>H]rauwolscine binding.	Guide to Pharmacology	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	35224877
		2695	3841	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		5504	3841	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		7310	3841	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		CHEMBL770	3841	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		DB00797	3841	81	None	-9	6	Human	6.7	pKi	=	6.7	Binding	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS bindingInhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding	Guide to Pharmacology	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	9605427
		174174	523	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		260	523	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		320	523	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		CHEMBL517712	523	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		DB00572	523	49	None	-43651	14	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	29860464
		12574	2605	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		4810	2605	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		CHEMBL19236	2605	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		DB09242	2605	88	None	-33	6	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	36101495
		523	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		523	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		5707	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		5707	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		CHEMBL297362	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		CHEMBL297362	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		DB11477	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	36101495
		DB11477	4106	93	None	-2	5	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	220	1	1	3	3.2	Cc1cccc(c1NC1=NCCCS1)C	9605427
		1960	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		1960	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		1960	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		439260	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		439260	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		439260	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		505	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		505	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		505	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		CHEMBL1437	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		CHEMBL1437	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		CHEMBL1437	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		DB00368	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	36101495
		DB00368	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9605427
		DB00368	2857	67	None	-23	26	Human	5.5	pKi	=	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	9824686
		1028	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		1028	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		1028	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		139148732	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		139148732	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		139148732	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		479	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		479	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		479	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		5816	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		5816	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		5816	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		CHEMBL679	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		CHEMBL679	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		CHEMBL679	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		DB00668	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	36101495
		DB00668	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9605427
		DB00668	291	71	None	-48	30	Human	5.6	pKi	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	9824686
		4209	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		4209	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		4209	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		4893	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		4893	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		4893	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		503	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		503	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		503	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		5385	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		5385	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		5385	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		CHEMBL2	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		CHEMBL2	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		CHEMBL2	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		DB00457	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	1353247
		DB00457	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	35224877
		DB00457	3163	75	None	-3235	33	Human	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	7908642
		2683	3834	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		5487	3834	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		7308	3834	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		CHEMBL1079	3834	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		DB00697	3834	60	None	-3	4	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	36101495
		2726	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		2726	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		2726	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		621	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		621	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		621	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		83	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		83	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		83	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		CHEMBL71	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		CHEMBL71	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		CHEMBL71	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		DB00477	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1353247
		DB00477	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	35224877
		DB00477	919	68	None	-87	72	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908642
		122211	462	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	1353247
		122211	462	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	35224877
		122211	462	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	7908642
		524	462	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	1353247
		524	462	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	35224877
		524	462	0	None	-239	6	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	5	0	5	3.6	COc1ccccc1N1CCN(CC1)CCC1C(=O)c2ccccc2C(C1=O)(C)C	7908642
		1343	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		1343	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		1343	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		3519	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		3519	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		3519	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		522	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		522	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		522	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		CHEMBL862	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		CHEMBL862	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		CHEMBL862	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		DB01018	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	36101495
		DB01018	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9283709
		DB01018	1889	62	None	-11	9	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	9605427
		11079	2733	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		3369	2733	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		4436	2733	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		5509	2733	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		CHEMBL761	2733	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		DB06711	2733	63	None	-1	5	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	36101495
		213046	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		213046	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		4168	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		4168	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		7461	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		7461	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		CHEMBL1237021	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		CHEMBL1237021	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		DB08815	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
		DB08815	2385	59	None	-19	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	35224877
		5268	3656	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	35224877
		5268	3656	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	7996470
		53	3656	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	35224877
		53	3656	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	7996470
		CHEMBL300555	3656	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	35224877
		CHEMBL300555	3656	40	None	-63	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	7996470
		12575	1988	30	None	-5	17	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	35224877
		54459	1988	30	None	-5	17	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	35224877
		CHEMBL10316	1988	30	None	-5	17	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	35224877
		2389	3331	118	None	-77	67	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		5073	3331	118	None	-77	67	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		96	3331	118	None	-77	67	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		CHEMBL85	3331	118	None	-77	67	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		DB00734	3331	118	None	-77	67	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	35224877
		3952	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		3952	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		5353646	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		5353646	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		5443	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		5443	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		5702063	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		5702063	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		CHEMBL1331786	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		CHEMBL1331786	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		CHEMBL420	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	36101495
		CHEMBL420	1888	38	None	-3	12	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	9605427
		13180	763	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	13	2	4	7.4	C(CCCCCNC1=C2C=CC=CC2=NC=C1)CCCCNC3=CC=NC4=C3C=CC=C4	32694911
		151782	763	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	13	2	4	7.4	C(CCCCCNC1=C2C=CC=CC2=NC=C1)CCCCNC3=CC=NC4=C3C=CC=C4	32694911
		CHEMBL121656	763	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	13	2	4	7.4	C(CCCCCNC1=C2C=CC=CC2=NC=C1)CCCCNC3=CC=NC4=C3C=CC=C4	32694911
		2435	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		2435	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		2435	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		2435	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		2435	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		395	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		395	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		395	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		395	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		395	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		520	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		520	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		520	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		520	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		520	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		5386	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		5386	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		5386	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		5386	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		5386	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		CHEMBL844	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		CHEMBL844	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		CHEMBL844	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		CHEMBL844	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		CHEMBL844	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		DB00484	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	36101495
		DB00484	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9227000
		DB00484	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9605427
		DB00484	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9760042
		DB00484	722	100	None	-2	12	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	9824686
		3658	4107	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		517	4107	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		5709	4107	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		CHEMBL312448	4107	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		DB06694	4107	53	None	-5	8	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	36101495
		2142	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		2142	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		2142	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		4920903	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		4920903	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		4920903	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		502	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		502	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		502	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		5775	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		5775	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		5775	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		CHEMBL597	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		CHEMBL597	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		CHEMBL597	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		DB00692	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	1353247
		DB00692	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	35224877
		DB00692	3096	58	None	-2	36	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	7908642
		2803	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		2803	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		2803	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		2803	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		516	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		516	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		516	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		516	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		704	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		704	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		704	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		704	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		CHEMBL134	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		CHEMBL134	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		CHEMBL134	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		CHEMBL134	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		DB00575	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	36101495
		DB00575	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9605427
		DB00575	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9760042
		DB00575	955	58	None	-1	19	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	9824686
		124	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		124	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		124	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		124	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		2032	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		2032	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		2032	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		2032	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		4636	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		4636	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		4636	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		4636	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		CHEMBL762	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		CHEMBL762	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		CHEMBL762	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		CHEMBL762	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		DB00935	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	36101495
		DB00935	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	7996470
		DB00935	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9227000
		DB00935	2981	47	None	-4	33	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	9605427
		121850	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	2573535
		121850	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	35224877
		121850	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	7996470
		525	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	2573535
		525	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	35224877
		525	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	7996470
		CHEMBL216097	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	2573535
		CHEMBL216097	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	35224877
		CHEMBL216097	726	0	None	41	3	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	215	2	1	3	1.6	CC1N(CC2=NCCN2)Cc2c1cccc2	7996470
		31101	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		31101	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		35	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		35	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		403	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		403	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		CHEMBL493	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		CHEMBL493	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		DB01200	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		DB01200	729	40	None	-10	36	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	36101495
		499	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	1353247
		499	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	35224877
		499	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	7908642
		5685	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	1353247
		5685	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	35224877
		5685	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	7908642
		CHEMBL25554	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	1353247
		CHEMBL25554	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	35224877
		CHEMBL25554	4077	18	None	-13	14	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	7908642
		313	2691	0	None	-2	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	29860464
		2216	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		229	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		7117	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		CHEMBL647	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		DB00964	446	50	None	1	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	244	1	3	4	1.9	Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1	8784451
		12576	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		71310	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		CHEMBL353972	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		DB11481	514	94	None	-2	6	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	2	1	1	2.9	CCC1(CC2=CC=CC=C2C1)C3=CN=CN3	35224877
		521	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		521	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		521	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		521	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		521	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		5311068	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		5311068	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		5311068	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		5311068	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		5311068	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		835	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		835	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		835	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		835	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		835	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		CHEMBL778	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		CHEMBL778	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		CHEMBL778	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		CHEMBL778	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		CHEMBL778	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		DB00633	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	36101495
		DB00633	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9227000
		DB00633	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9605427
		DB00633	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9760042
		DB00633	1404	69	None	-6	7	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	9824686
		108094	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		108094	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		526	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		526	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		528	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		528	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		CHEMBL10332	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	35224877
		CHEMBL10332	3423	27	None	-1	4	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	234	2	1	5	0.8	COC1(COc2c(O1)cccc2)C1=NCCN1	7996470
		12577	2563	0	None	-15	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	0	0	3	3.3	CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C	35224877
		189711	2563	0	None	-15	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	0	0	3	3.3	CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C	35224877
		CHEMBL1257057	2563	0	None	-15	3	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	0	0	3	3.3	CN1CC[C@]2(CCN3CCC4=C([C@@H]3C2)OC5=CC=CC=C45)N(C1=O)C	35224877
		102	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		102	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		102	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		102	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		3659	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		3659	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		3659	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		3659	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		8969	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		8969	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		8969	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		8969	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		CHEMBL15245	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		CHEMBL15245	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		CHEMBL15245	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		CHEMBL15245	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		DB01392	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	1353247
		DB01392	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	35224877
		DB01392	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7908642
		DB01392	4127	48	None	-5	49	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		13128	3400	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	364	3	0	4	2.4	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC	35224877
		9908992	3400	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	364	3	0	4	2.4	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC	35224877
		CHEMBL4303564	3400	0	None	-3	3	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	364	3	0	4	2.4	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C=C(C=C4)OC	35224877
		1588	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		1588	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		28864	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		28864	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		43	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		43	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		CHEMBL157138	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL157138	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		DB00589	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB00589	2325	27	None	1	44	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	35224877
		2995	204405	53	None	-12	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	None	-12	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	None	-12	23	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		179	400	115	None	-35	49	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	None	-35	49	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	None	-35	49	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	None	-35	49	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	None	-35	49	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		3337	206367	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	None	-27	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		119570	3159	96	None	-69	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	None	-69	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	None	-69	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	None	-69	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	None	-69	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		46780481	107531	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	None	-47	53	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		228	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		33	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		6005	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		CHEMBL53	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		DB00714	445	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
		2202	3132	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		4850	3132	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		49	3132	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		CHEMBL1371770	3132	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		DB12478	3132	96	None	-1	21	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
		2105	3054	37	None	-58	33	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		47811	3054	37	None	-58	33	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		48	3054	37	None	-58	33	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		CHEMBL531	3054	37	None	-58	33	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		DB01186	3054	37	None	-58	33	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		37	778	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		460	778	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		54746	778	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		CHEMBL1201087	778	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		DB00248	778	60	None	-3	17	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		136	3292	32	None	-3	15	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		223	3292	32	None	-3	15	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		643606	3292	32	None	-3	15	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		CHEMBL10347	3292	32	None	-3	15	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	7996470
		2601	3780	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		443951	3780	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		56	3780	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL73151	3780	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB13399	3780	33	None	-1	21	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666

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Ligand source activities (1 row/activity)